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TDMS Study 05172-01 Pathology Tables

NTP Experiment-Test: 05172-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                               3,3-DIMETHOXYBENZIDINE DIHYDROCHLORIDE                          Date: 04/30/97
Route: DOSED WATER                                                                                                Time: 17:38:14




       Facility:  Hazleton Laboratories America, Inc.

       Chemical CAS #:  20325400

       Lock Date:  None

       Cage Range:  All

       Reasons For Removal:    All

       Removal Date Range:     All

       Treatment Groups:       Include All






































                                                              Page   1

NTP Experiment-Test: 05172-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                               3,3-DIMETHOXYBENZIDINE DIHYDROCHLORIDE                          Date: 04/30/97  
Route: DOSED WATER                                                                                                Time: 17:38:14  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 6| 6| 6| 6| 4| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|             
                             DAY ON TEST   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 4| 4| 4| 4| 0| 4| 4| 4| 2| 2| 4| 4| 4| 4| 4|             
                                           | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 8| 8| 8| 8| 2| 8| 8| 8| 4| 4| 8| 8| 8| 8| 8|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    CONTROL                                | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               |                               +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large                         |                               +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  |                               +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  |                               +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 |                               +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small                         |                               +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               |                               +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  |                               +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                |                               +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Liver                                   |                               +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis, Focal                   |                                                                          |             
      Angiectasis                          |                                                                          |             
      Basophilic Focus                     |                               2  2  3  3     3  1  1     2  3  1  2  2  2|             
      Clear Cell Focus                     |                                                                          |             
      Degeneration, Cystic                 |                                              1                           |             
      Eosinophilic Focus                   |                                              2     3                     |             
      Fatty Change                         |                                                                          |             
      Granuloma                            |                                  2                 2           2  2      |             
      Hematopoietic Cell Proliferation     |                               1                                          |             
      Hepatodiaphragmatic Nodule           |                                                       X                  |             
      Hepatodiaphragmatic Nodule, Multiple |                                                                          |             
      Regeneration, Diffuse                |                                                       2                  |             
      Vacuolization Cytoplasmic, Focal     |                                                                          |             
      Vacuolization Cytoplasmic, Multifocal|                                                                          |             
      Bile Duct, Hyperplasia               |                                              2                           |             
      Centrilobular, Degeneration          |                                                                          |             
      Centrilobular, Necrosis              |                                                       2                  |             
                                            __________________________________________________________________________|             
   Mesentery                               |                                                                          |             
      Fat, Necrosis                        |                                                                          |             
                                            __________________________________________________________________________|             
   Pancreas                                |                               +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                                  2                                       |             
                                            __________________________________________________________________________|             
   Pharynx                                 |                                                    +                     |             
                                            __________________________________________________________________________|             
   Salivary Glands                         |                               +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                                                       3                  |             
                                            __________________________________________________________________________|             
   Stomach                                 |                               +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    |                               +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      |                               +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Tongue                                  |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   |                               +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cardiomyopathy, Chronic              |                                     2  2     2  2  1     2  2  2  2  2   |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   2                                                               
NTP Experiment-Test: 05172-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                               3,3-DIMETHOXYBENZIDINE DIHYDROCHLORIDE                          Date: 04/30/97  
Route: DOSED WATER                                                                                                Time: 17:38:14  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 6| 6| 6| 6| 4| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|             
                             DAY ON TEST   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 4| 4| 4| 4| 0| 4| 4| 4| 2| 2| 4| 4| 4| 4| 4|             
                                           | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 8| 8| 8| 8| 2| 8| 8| 8| 4| 4| 8| 8| 8| 8| 8|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    CONTROL                                | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           |                               +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   |                               +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Degeneration, Focal                  |                                                                          |             
      Hyperplasia, Focal                   |                               2              2                           |             
      Hypertrophy, Focal                   |                                                                          |             
      Vacuolization Cytoplasmic, Focal     |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  |                               +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Focal                   |                               1              1        2                  |             
      Hyperplasia, Multifocal              |                                                                          |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      |                               +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       |                               +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         |                               +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Pars Distalis, Angiectasis           |                                                                          |             
      Pars Distalis, Cyst                  |                                  X  X  X  X     X                    X   |             
      Pars Distalis, Hemorrhage            |                                                                          |             
      Pars Distalis, Hyperplasia, Diffuse  |                                                                          |             
      Pars Distalis, Hyperplasia, Focal    |                                                             2            |             
      Pars Distalis, Hyperplasia           |                                                                          |             
      Pars Distalis, Hyperplasia,          |                                                                          |             
          Multifocal                       |                                                                          |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           |                               +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      C-Cell, Hyperplasia, Focal           |                                     2  1              1                  |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Clitoral Gland                          |                               +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                                                       3                  |             
      Ectasia                              |                                                       3                  |             
      Hyperplasia, Focal                   |                                        3                                 |             
      Hyperplasia, Focal, Squamous         |                                                                          |             
      Inflammation, Chronic                |                                                                          |             
                                            __________________________________________________________________________|             
   Ovary                                   |                               +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                                                   X      |             
      Bilateral, Cyst                      |                                                                          |             
      Germinal Epithelium, Hyperplasia,    |                                                                          |             
           Focal, Papillary                |                                                                          |             
                                            __________________________________________________________________________|             
   Uterus                                  |                               +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                                                          |             
      Hydrometra                           |                                                             3            |             
      Cervix, Cyst                         |                                                                          |             
      Cervix, Fibrosis                     |                                     3        3                           |             
      Cervix, Prolapse                     |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   3                                                               
NTP Experiment-Test: 05172-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                               3,3-DIMETHOXYBENZIDINE DIHYDROCHLORIDE                          Date: 04/30/97  
Route: DOSED WATER                                                                                                Time: 17:38:14  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 6| 6| 6| 6| 4| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|             
                             DAY ON TEST   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 4| 4| 4| 4| 0| 4| 4| 4| 2| 2| 4| 4| 4| 4| 4|             
                                           | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 8| 8| 8| 8| 2| 8| 8| 8| 4| 4| 8| 8| 8| 8| 8|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    CONTROL                                | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
      Endometrium, Cyst                    |                                                                          |             
                                            __________________________________________________________________________|             
   Vagina                                  |                                                                          |             
      Thrombosis, Multiple                 |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             |                               +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                                                          |             
      Hypoplasia                           |                                                       3                  |             
      Myelofibrosis                        |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node                              |                               +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Mediastinal, Hyperplasia, Lymphoid   |                                           3                              |             
      Mediastinal, Pigmentation            |                                                                          |             
      Pancreatic, Pigmentation             |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  |                               +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Lymphoid                |                                           3                              |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  |                               +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Reticulum Cell          |                                           2                              |             
                                            __________________________________________________________________________|             
   Spleen                                  |                               +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hematopoietic Cell Proliferation     |                               2           2                              |             
      Pigmentation                         |                                                          2        3      |             
                                            __________________________________________________________________________|             
   Thymus                                  |                               +  +  M  +  +  +  +  M  +  +  +  +  M  +  +|             
      Epithelial Cell, Hyperplasia         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           |                               +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Galactocele                          |                                                                          |             
      Duct, Ectasia                        |                                                    3           3  3  3   |             
                                            __________________________________________________________________________|             
   Skin                                    |                               +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    |                                              +                           |             
      Sternum, Osteopetrosis               |                                              3                           |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   |                               +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cerebrum, Compression                |                               X                    X              X      |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    |                               +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage, Focal                    |                                                                          |             
      Hyperplasia, Lymphoid                |                               2  2  2  2  2  2  2  2     2  2  2  2  2  2|             
      Alveolar Epithelium, Hyperplasia,    |                                                                          |             
           Focal                           |                                                                          |             
                                            __________________________________________________________________________|             
   Nose                                    |                               +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page   4                                                               
NTP Experiment-Test: 05172-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                               3,3-DIMETHOXYBENZIDINE DIHYDROCHLORIDE                          Date: 04/30/97  
Route: DOSED WATER                                                                                                Time: 17:38:14  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 6| 6| 6| 6| 4| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|             
                             DAY ON TEST   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 4| 4| 4| 4| 0| 4| 4| 4| 2| 2| 4| 4| 4| 4| 4|             
                                           | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 8| 8| 8| 8| 2| 8| 8| 8| 4| 4| 8| 8| 8| 8| 8|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    CONTROL                                | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
      Inflammation, Acute                  |                                                                          |             
                                            __________________________________________________________________________|             
   Trachea                                 |                               +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                                                                          |             
                                            __________________________________________________________________________|             
   Zymbal's Gland                          |                               +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Ectasia                              |                                                       1        2         |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  |                               +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Infarct, Chronic                     |                                                                          |             
      Nephropathy, Chronic                 |                               3  2  1  2     3  2  4     1  2  2  1     2|             
      Renal Tubule, Pigmentation           |                                           1                              |             
                                            __________________________________________________________________________|             
   Ureter                                  |                                                                          |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         |                               +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   5                                                               
NTP Experiment-Test: 05172-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                               3,3-DIMETHOXYBENZIDINE DIHYDROCHLORIDE                          Date: 04/30/97  
Route: DOSED WATER                                                                                                Time: 17:38:14  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 6| 6| 6| 5| 6| 6| 6| 6| 5| 6| 6| 6| 6| 5| 6| 6| 6| 6| 5| 6| 6| 6| 6| 5|             
                             DAY ON TEST   | 4| 4| 4| 3| 7| 4| 4| 4| 0| 2| 4| 4| 4| 4| 7| 4| 4| 4| 4| 9| 4| 4| 4| 5| 4|             
                                           | 8| 8| 8| 1| 4| 8| 8| 8| 2| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 8| 8| 8| 1| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    CONTROL                                | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis, Focal                   |                                                                          |             
      Angiectasis                          |                                                    1                     |             
      Basophilic Focus                     | 3  2  2        2  1  2     1  2  1  1  1     2  2        1  2  2  2  1  2|             
      Clear Cell Focus                     | 1                             2                 1  2                     |             
      Degeneration, Cystic                 |                                                                          |             
      Eosinophilic Focus                   |                2                       1                                 |             
      Fatty Change                         |                                                                          |             
      Granuloma                            |                   2           2        2                             1   |             
      Hematopoietic Cell Proliferation     |                                                                          |             
      Hepatodiaphragmatic Nodule           |       X                                                                  |             
      Hepatodiaphragmatic Nodule, Multiple |                                                                          |             
      Regeneration, Diffuse                |                      2                    2                             2|             
      Vacuolization Cytoplasmic, Focal     |                                                    2                     |             
      Vacuolization Cytoplasmic, Multifocal|                               2                          2               |             
      Bile Duct, Hyperplasia               |                                                                          |             
      Centrilobular, Degeneration          |                            1                                             |             
      Centrilobular, Necrosis              |                                                                          |             
                                            __________________________________________________________________________|             
   Mesentery                               | +     +                                   +     +                        |             
      Fat, Necrosis                        | 3     3                                   2     3                        |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                2                                            2            |             
                                            __________________________________________________________________________|             
   Pharynx                                 |                                                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Tongue                                  |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cardiomyopathy, Chronic              | 2  2  1           1              2              1  1                 1   |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   6                                                               
NTP Experiment-Test: 05172-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                               3,3-DIMETHOXYBENZIDINE DIHYDROCHLORIDE                          Date: 04/30/97  
Route: DOSED WATER                                                                                                Time: 17:38:14  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 6| 6| 6| 5| 6| 6| 6| 6| 5| 6| 6| 6| 6| 5| 6| 6| 6| 6| 5| 6| 6| 6| 6| 5|             
                             DAY ON TEST   | 4| 4| 4| 3| 7| 4| 4| 4| 0| 2| 4| 4| 4| 4| 7| 4| 4| 4| 4| 9| 4| 4| 4| 5| 4|             
                                           | 8| 8| 8| 1| 4| 8| 8| 8| 2| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 8| 8| 8| 1| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    CONTROL                                | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Degeneration, Focal                  |                                                                          |             
      Hyperplasia, Focal                   |                                     3           3                        |             
      Hypertrophy, Focal                   |                   2                                                      |             
      Vacuolization Cytoplasmic, Focal     |                   2                                                      |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Focal                   |       2                                               2                  |             
      Hyperplasia, Multifocal              |          1                                                               |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  M  +  +  +|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Pars Distalis, Angiectasis           |                      2        2     3                                    |             
      Pars Distalis, Cyst                  |             4  X  X                             X                        |             
      Pars Distalis, Hemorrhage            |                                                       3                  |             
      Pars Distalis, Hyperplasia, Diffuse  |                                  3                                       |             
      Pars Distalis, Hyperplasia, Focal    |    2  2                       2     2                                    |             
      Pars Distalis, Hyperplasia           |                                                                          |             
      Pars Distalis, Hyperplasia,          |                                                                          |             
          Multifocal                       |                                                                          |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      C-Cell, Hyperplasia, Focal           |    1                                                                     |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Clitoral Gland                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                         3                                                |             
      Ectasia                              | 3        3        3                                                      |             
      Hyperplasia, Focal                   |                                     3                                    |             
      Hyperplasia, Focal, Squamous         |                                                                          |             
      Inflammation, Chronic                |                                                                          |             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                     X  X                 X     X         |             
      Bilateral, Cyst                      |                                              X                           |             
      Germinal Epithelium, Hyperplasia,    |                                                                          |             
           Focal, Papillary                |                                                          2               |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                X                                                         |             
      Hydrometra                           |                         2                                                |             
      Cervix, Cyst                         |                                  X                                       |             
      Cervix, Fibrosis                     |    2              3                          2        2                  |             
      Cervix, Prolapse                     |                                              4                           |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   7                                                               
NTP Experiment-Test: 05172-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                               3,3-DIMETHOXYBENZIDINE DIHYDROCHLORIDE                          Date: 04/30/97  
Route: DOSED WATER                                                                                                Time: 17:38:14  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 6| 6| 6| 5| 6| 6| 6| 6| 5| 6| 6| 6| 6| 5| 6| 6| 6| 6| 5| 6| 6| 6| 6| 5|             
                             DAY ON TEST   | 4| 4| 4| 3| 7| 4| 4| 4| 0| 2| 4| 4| 4| 4| 7| 4| 4| 4| 4| 9| 4| 4| 4| 5| 4|             
                                           | 8| 8| 8| 1| 4| 8| 8| 8| 2| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 8| 8| 8| 1| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    CONTROL                                | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
      Endometrium, Cyst                    |                                                                          |             
                                            __________________________________________________________________________|             
   Vagina                                  |                            +                                             |             
      Thrombosis, Multiple                 |                            3                                             |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                           2                             2|             
      Hypoplasia                           |                                                                          |             
      Myelofibrosis                        |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Mediastinal, Hyperplasia, Lymphoid   |                                                                          |             
      Mediastinal, Pigmentation            |                                                                          |             
      Pancreatic, Pigmentation             |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Lymphoid                |                   3                                                      |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Reticulum Cell          |                                  3                                       |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hematopoietic Cell Proliferation     |                                                                          |             
      Pigmentation                         |                                                          3               |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  M  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Epithelial Cell, Hyperplasia         |                                     3                                    |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Galactocele                          | X                       X                                                |             
      Duct, Ectasia                        |    3  3                    3           3                 2        3  3  2|             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    |                                  +                                       |             
      Sternum, Osteopetrosis               |                                  4                                       |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cerebrum, Compression                |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage, Focal                    |                                                                          |             
      Hyperplasia, Lymphoid                | 2  2  2        3  2  2     2     2  2  3     2  3  2  2  2  2  2  2  2   |             
      Alveolar Epithelium, Hyperplasia,    |                                                                          |             
           Focal                           |    1                                            1                 2      |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page   8                                                               
NTP Experiment-Test: 05172-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                               3,3-DIMETHOXYBENZIDINE DIHYDROCHLORIDE                          Date: 04/30/97  
Route: DOSED WATER                                                                                                Time: 17:38:14  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 6| 6| 6| 5| 6| 6| 6| 6| 5| 6| 6| 6| 6| 5| 6| 6| 6| 6| 5| 6| 6| 6| 6| 5|             
                             DAY ON TEST   | 4| 4| 4| 3| 7| 4| 4| 4| 0| 2| 4| 4| 4| 4| 7| 4| 4| 4| 4| 9| 4| 4| 4| 5| 4|             
                                           | 8| 8| 8| 1| 4| 8| 8| 8| 2| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 8| 8| 8| 1| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    CONTROL                                | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
      Inflammation, Acute                  |                   2                                                      |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                                     +                                    |             
                                            __________________________________________________________________________|             
   Zymbal's Gland                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Ectasia                              |             3           2        2                 2     2              2|             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Infarct, Chronic                     |                                                                      3   |             
      Nephropathy, Chronic                 | 2  1  1        2  1  1  1     3  2  1  2     2  2  2  2  1  1  2  2  3   |             
      Renal Tubule, Pigmentation           |                                           4                              |             
                                            __________________________________________________________________________|             
   Ureter                                  |                                     +  +                                 |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |                            4                                             |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   9                                                               
NTP Experiment-Test: 05172-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                               3,3-DIMETHOXYBENZIDINE DIHYDROCHLORIDE                          Date: 04/30/97  
Route: DOSED WATER                                                                                                Time: 17:38:14  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 6| 6| 6| 5| 6| 6| 6| 6| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|              |            |
                             DAY ON TEST   | 5| 5| 5| 5| 3| 5| 5| 5| 5| 9| 5| 4| 4| 1| 0| 5| 5| 4| 5| 5|              |            |
                                           | 1| 1| 1| 1| 2| 1| 1| 1| 1| 0| 1| 4| 8| 8| 0| 1| 1| 8| 1| 1|              |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|              |      A     |
    CONTROL                                | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|              |      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|              |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  60        |
                                            __________________________________________________________________________|____________|
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  60        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  60        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  60        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  60        |
                                            __________________________________________________________________________|____________|
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  60        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  60        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  60        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  60        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  60        |
      Angiectasis, Focal                   |                      3                                                   |      1  3.0|
      Angiectasis                          |                                                                          |      1  1.0|
      Basophilic Focus                     |    2  1  2     1  2  2     1  2     3           2     2  2               |     44  1.8|
      Clear Cell Focus                     |       1        1        1                                                |      7  1.3|
      Degeneration, Cystic                 |                                                                          |      1  1.0|
      Eosinophilic Focus                   |                               1                                          |      5  1.8|
      Fatty Change                         |                                           3                              |      1  3.0|
      Granuloma                            |                            4     2                                       |     10  2.1|
      Hematopoietic Cell Proliferation     |                                                                          |      1  1.0|
      Hepatodiaphragmatic Nodule           |    X                                            X        X               |      5     |
      Hepatodiaphragmatic Nodule, Multiple |                                        X                                 |      1     |
      Regeneration, Diffuse                |             2                                      2                     |      6  2.0|
      Vacuolization Cytoplasmic, Focal     |                                                                          |      1  2.0|
      Vacuolization Cytoplasmic, Multifocal|                                                                          |      2  2.0|
      Bile Duct, Hyperplasia               |                                                                          |      1  2.0|
      Centrilobular, Degeneration          |                                                                          |      1  1.0|
      Centrilobular, Necrosis              |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Mesentery                               |                                           +        +                     |   6        |
      Fat, Necrosis                        |                                           3        3                     |      6  2.8|
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  60        |
      Atrophy                              |          2                                                               |      4  2.0|
                                            __________________________________________________________________________|____________|
   Pharynx                                 |                                                                          |   1        |
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  59        |
      Atrophy                              |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  60        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  60        |
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  60        |
                                            __________________________________________________________________________|____________|
   Tongue                                  |                                              +                           |   1        |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  10                                                               
NTP Experiment-Test: 05172-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                               3,3-DIMETHOXYBENZIDINE DIHYDROCHLORIDE                          Date: 04/30/97  
Route: DOSED WATER                                                                                                Time: 17:38:14  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 6| 6| 6| 5| 6| 6| 6| 6| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|              |            |
                             DAY ON TEST   | 5| 5| 5| 5| 3| 5| 5| 5| 5| 9| 5| 4| 4| 1| 0| 5| 5| 4| 5| 5|              |            |
                                           | 1| 1| 1| 1| 2| 1| 1| 1| 1| 0| 1| 4| 8| 8| 0| 1| 1| 8| 1| 1|              |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|              |      A     |
    CONTROL                                | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|              |      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|              |            |
 __________________________________________________________________________________________________________________________________ 
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |            |
                                           |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  60        |
      Cardiomyopathy, Chronic              | 2              1                 1           2  2     1  1               |     25  1.6|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  60        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  60        |
      Degeneration, Focal                  |                      3                                                   |      1  3.0|
      Hyperplasia, Focal                   |                                                 1                        |      5  2.2|
      Hypertrophy, Focal                   |                                              2                           |      2  2.0|
      Vacuolization Cytoplasmic, Focal     |                                              2                           |      2  2.0|
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  60        |
      Hyperplasia, Focal                   |                                                                          |      5  1.6|
      Hyperplasia, Multifocal              |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  60        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  58        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  60        |
      Pars Distalis, Angiectasis           |                                                                          |      3  2.3|
      Pars Distalis, Cyst                  |                X     X  X                                X               |     14  4.0|
      Pars Distalis, Hemorrhage            |                                                                          |      1  3.0|
      Pars Distalis, Hyperplasia, Diffuse  |                                                                          |      1  3.0|
      Pars Distalis, Hyperplasia, Focal    |                                                                          |      5  2.0|
      Pars Distalis, Hyperplasia           |                                        2                                 |      1  2.0|
      Pars Distalis, Hyperplasia,          |                                                                          |            |
          Multifocal                       |                2                                                         |      1  2.0|
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  60        |
      C-Cell, Hyperplasia, Focal           |    2                                               3                     |      6  1.7|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Clitoral Gland                          | +  +  +  +  +  +  +  +  +  +  +  +  M  M  +  +  +  +  +  +               |  58        |
      Atrophy                              |                                           3                              |      3  3.0|
      Ectasia                              | 4  3  3  2     2     3     3  4           3        3     3               |     15  3.0|
      Hyperplasia, Focal                   |          3                                                               |      3  3.0|
      Hyperplasia, Focal, Squamous         |                               3                                          |      1  3.0|
      Inflammation, Chronic                |                                                    3                     |      1  3.0|
                                            __________________________________________________________________________|____________|
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  60        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  11                                                               
NTP Experiment-Test: 05172-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                               3,3-DIMETHOXYBENZIDINE DIHYDROCHLORIDE                          Date: 04/30/97  
Route: DOSED WATER                                                                                                Time: 17:38:14  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 6| 6| 6| 5| 6| 6| 6| 6| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|              |            |
                             DAY ON TEST   | 5| 5| 5| 5| 3| 5| 5| 5| 5| 9| 5| 4| 4| 1| 0| 5| 5| 4| 5| 5|              |            |
                                           | 1| 1| 1| 1| 2| 1| 1| 1| 1| 0| 1| 4| 8| 8| 0| 1| 1| 8| 1| 1|              |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|              |      A     |
    CONTROL                                | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|              |      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|              |            |
 __________________________________________________________________________________________________________________________________ 
 GENITAL SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
      Cyst                                 |          X                                                               |      6     |
      Bilateral, Cyst                      |                                                                          |      1     |
      Germinal Epithelium, Hyperplasia,    |                                                                          |            |
           Focal, Papillary                |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  60        |
      Cyst                                 |                                                                          |      1     |
      Hydrometra                           |                                                          3               |      3  2.7|
      Cervix, Cyst                         |                      X                                                   |      2     |
      Cervix, Fibrosis                     | 2              2     2           3  2                                    |     11  2.4|
      Cervix, Prolapse                     |                                                                          |      1  4.0|
      Endometrium, Cyst                    |                   X                                                      |      1     |
                                            __________________________________________________________________________|____________|
   Vagina                                  |                                                                          |   1        |
      Thrombosis, Multiple                 |                                                                          |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  60        |
      Hyperplasia                          |                         2  2           2                                 |      5  2.0|
      Hypoplasia                           |                                                    3                     |      2  3.0|
      Myelofibrosis                        |                                                    4                     |      1  4.0|
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  60        |
      Mediastinal, Hyperplasia, Lymphoid   |                                                                          |      1  3.0|
      Mediastinal, Pigmentation            |                                           3                              |      1  3.0|
      Pancreatic, Pigmentation             |                                           3                              |      1  3.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  59        |
      Hyperplasia, Lymphoid                |                                                                          |      2  3.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  60        |
      Hyperplasia, Reticulum Cell          |                                                                          |      2  2.5|
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  60        |
      Hematopoietic Cell Proliferation     |                                           2                              |      3  2.0|
      Pigmentation                         |                               2           3                              |      5  2.6|
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  M               |  53        |
      Epithelial Cell, Hyperplasia         |                                                                          |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  59        |
      Galactocele                          |                                                                          |      2     |
      Duct, Ectasia                        | 3                                         3        3     3               |     16  2.9|
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  60        |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  12                                                               
NTP Experiment-Test: 05172-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                               3,3-DIMETHOXYBENZIDINE DIHYDROCHLORIDE                          Date: 04/30/97  
Route: DOSED WATER                                                                                                Time: 17:38:14  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 6| 6| 6| 5| 6| 6| 6| 6| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|              |            |
                             DAY ON TEST   | 5| 5| 5| 5| 3| 5| 5| 5| 5| 9| 5| 4| 4| 1| 0| 5| 5| 4| 5| 5|              |            |
                                           | 1| 1| 1| 1| 2| 1| 1| 1| 1| 0| 1| 4| 8| 8| 0| 1| 1| 8| 1| 1|              |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|              |      A     |
    CONTROL                                | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|              |      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|              |            |
 __________________________________________________________________________________________________________________________________ 
 MUSCULOSKELETAL SYSTEM - cont             |                                                                          |            |
                                           |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    |                                                                          |   2        |
      Sternum, Osteopetrosis               |                                                                          |      2  3.5|
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  60        |
      Cerebrum, Compression                |          X                 X  X  X        X                              |      8     |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  60        |
      Hemorrhage, Focal                    |                                                    1                     |      1  1.0|
      Hyperplasia, Lymphoid                | 2  2     2     2  2        2  2           2  2  2     2  2               |     45  2.1|
      Alveolar Epithelium, Hyperplasia,    |                                                                          |            |
           Focal                           |                                                 1  3                     |      5  1.6|
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  60        |
      Inflammation, Acute                  |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  60        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Eye                                     |                                                                          |   1        |
                                            __________________________________________________________________________|____________|
   Zymbal's Gland                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  60        |
      Ectasia                              |                2                 2        2        2                     |     12  2.0|
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  60        |
      Infarct, Chronic                     |                                                                          |      1  3.0|
      Nephropathy, Chronic                 | 2  2  2  3     1  2  2  1  2  3  2  2     2  2  1  1  1  2               |     50  1.8|
      Renal Tubule, Pigmentation           |                                                                          |      2  2.5|
                                            __________________________________________________________________________|____________|
   Ureter                                  |                                                                          |   2        |
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  60        |
      Hemorrhage                           |                                                                          |      1  4.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  13                                                               
NTP Experiment-Test: 05172-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                               3,3-DIMETHOXYBENZIDINE DIHYDROCHLORIDE                          Date: 04/30/97  
Route: DOSED WATER                                                                                                Time: 17:38:14  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 6| 5| 5| 4| 6| 6| 6| 5| 4| 6| 6| 6| 5| 4| 6| 6| 6| 5| 4| 6| 6| 6| 6| 5|             
                             DAY ON TEST   | 4| 4| 6| 2| 8| 4| 4| 1| 9| 8| 4| 4| 1| 8| 8| 4| 1| 1| 1| 2| 4| 4| 4| 0| 7|             
                                           | 8| 8| 4| 0| 5| 8| 8| 8| 9| 5| 4| 8| 8| 8| 3| 8| 8| 6| 2| 4| 8| 8| 8| 6| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    80 PPM                                 | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A|             
      Parasite Metazoan                    |                                                          1               |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A|             
      Parasite Metazoan                    |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A|             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A|             
      Angiectasis, Focal                   |                   3                                                      |             
      Basophilic Focus                     | 2  2     1  2  2  2  2  2  1  2  2     1  1  2  2  2        2  2  2      |             
      Clear Cell Focus                     |             1  2  1  2           2  2           2                        |             
      Degeneration, Cystic                 |    1                                                                     |             
      Eosinophilic Focus                   |                                  2  1           2                        |             
      Fatty Change                         |                                                    3                     |             
      Granuloma                            |                                                                          |             
      Hematopoietic Cell Proliferation     |    2     2  2           2  1  1  1  3  1                                 |             
      Hepatodiaphragmatic Nodule           |                      X  X                             X                  |             
      Necrosis, Multifocal                 |                                                                          |             
      Pigmentation                         |                                                    1                     |             
      Regeneration, Diffuse                |       2                                                                  |             
      Regeneration, Multifocal             |                                                                          |             
      Vacuolization Cytoplasmic, Focal     |                      2                                                   |             
      Bile Duct, Hyperplasia               |                                  2                                       |             
      Centrilobular, Degeneration, Diffuse |                         2                                                |             
      Centrilobular, Degeneration          |                                                                          |             
      Centrilobular, Necrosis, Diffuse     |          2                                                               |             
      Centrilobular, Necrosis              |                                                                          |             
                                            __________________________________________________________________________|             
   Mesentery                               |                                                 +                        |             
      Fat, Necrosis                        |                                                 3                        |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A|             
      Atrophy                              | 2                                      2           3                     |             
                                            __________________________________________________________________________|             
   Pharynx                                 |                                                                +         |             
      Palate, Hyperkeratosis, Focal        |                                                                2         |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic                |                                           4                              |             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Erosion, Focal                       |                                                                          |             
                                            __________________________________________________________________________|             
   Tongue                                  |                               +                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  14                                                               
NTP Experiment-Test: 05172-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                               3,3-DIMETHOXYBENZIDINE DIHYDROCHLORIDE                          Date: 04/30/97  
Route: DOSED WATER                                                                                                Time: 17:38:14  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 6| 5| 5| 4| 6| 6| 6| 5| 4| 6| 6| 6| 5| 4| 6| 6| 6| 5| 4| 6| 6| 6| 6| 5|             
                             DAY ON TEST   | 4| 4| 6| 2| 8| 4| 4| 1| 9| 8| 4| 4| 1| 8| 8| 4| 1| 1| 1| 2| 4| 4| 4| 0| 7|             
                                           | 8| 8| 4| 0| 5| 8| 8| 8| 9| 5| 4| 8| 8| 8| 3| 8| 8| 6| 2| 4| 8| 8| 8| 6| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    80 PPM                                 | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cardiomyopathy, Chronic              | 1  2     2     1  1  1           2  1        1              2     1      |             
      Atrium, Thrombosis                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Degeneration, Focal                  |                                                                          |             
      Hyperplasia, Focal                   |                                                                          |             
      Hypertrophy, Focal                   |                                                             2            |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Pars Distalis, Angiectasis           |                4                                               3         |             
      Pars Distalis, Cyst                  | X                                X           X  X                        |             
      Pars Distalis, Hyperplasia, Diffuse  | 3                                3                                       |             
      Pars Distalis, Hyperplasia, Focal    |    2                    2                                            3   |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      C-Cell, Hyperplasia, Focal           |                         2                    1              2            |             
      C-Cell, Hyperplasia, Multifocal      |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Clitoral Gland                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Ectasia                              |    4           3  3                                   3  2  4            |             
      Hyperplasia, Focal                   |       2           2                                                      |             
      Hyperplasia, Focal, Squamous         |                2                                                         |             
      Hyperplasia, Multifocal              |    3                                                           3         |             
      Hyperplasia, Multifocal, Squamous    |                                                                          |             
      Inflammation, Acute                  |                                                                          |             
      Necrosis                             |                                                                          |             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                           2  X           3               |             
                                            __________________________________________________________________________|             
   Oviduct                                 |                                                                          |             
      Thrombosis                           |                                                                          |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hydrometra                           |                   3                                                      |             
      Inflammation, Acute                  |                                                                      3   |             
      Thrombosis                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  15                                                               
NTP Experiment-Test: 05172-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                               3,3-DIMETHOXYBENZIDINE DIHYDROCHLORIDE                          Date: 04/30/97  
Route: DOSED WATER                                                                                                Time: 17:38:14  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 6| 5| 5| 4| 6| 6| 6| 5| 4| 6| 6| 6| 5| 4| 6| 6| 6| 5| 4| 6| 6| 6| 6| 5|             
                             DAY ON TEST   | 4| 4| 6| 2| 8| 4| 4| 1| 9| 8| 4| 4| 1| 8| 8| 4| 1| 1| 1| 2| 4| 4| 4| 0| 7|             
                                           | 8| 8| 4| 0| 5| 8| 8| 8| 9| 5| 4| 8| 8| 8| 3| 8| 8| 6| 2| 4| 8| 8| 8| 6| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    80 PPM                                 | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
      Bilateral, Hydrometra                |                                                          3               |             
      Cervix, Fibrosis                     |                2                                                  2      |             
      Endometrium, Cyst                    |                                           3           3                  |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |    3        2              2                    2                        |             
      Myelofibrosis                        |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Mediastinal, Erythrophagocytosis     |                                     2                                    |             
      Mediastinal, Infiltration Cellular,  |                                                                          |             
           Histiocyte                      |                                     3                                    |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Lymphoid                |                                           4        3     3               |             
      Hyperplasia, Reticulum Cell          |                                                 3                        |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M|             
      Hyperplasia, Reticulum Cell          |                                              3  3                 3      |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hematopoietic Cell Proliferation     |    3     4  3  2     3  4  3  3  2  3  3                          2      |             
      Hyperplasia, Reticulum Cell          |                                                                          |             
      Pigmentation                         |                                                    2                     |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  M  +|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Galactocele                          |                                                                          |             
      Duct, Ectasia                        |          3                    3  3                 3                     |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hair Follicle, Hyperplasia, Basal    |                                                                          |             
          Cell, Multifocal                 |                                                                          |             
      Subcutaneous Tissue, Abscess, Focal  |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    |          +                                                           +   |             
      Sternum, Osteopetrosis               |          3                                                               |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cerebrum, Compression                |                               X                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Lymphoid                |          2  2     2     2  2  2  2     3  3  2  2  2     1  2     2  2   |             
      Infiltration Cellular, Histiocyte    |                      2              3                                1   |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  16                                                               
NTP Experiment-Test: 05172-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                               3,3-DIMETHOXYBENZIDINE DIHYDROCHLORIDE                          Date: 04/30/97  
Route: DOSED WATER                                                                                                Time: 17:38:14  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 6| 5| 5| 4| 6| 6| 6| 5| 4| 6| 6| 6| 5| 4| 6| 6| 6| 5| 4| 6| 6| 6| 6| 5|             
                             DAY ON TEST   | 4| 4| 6| 2| 8| 4| 4| 1| 9| 8| 4| 4| 1| 8| 8| 4| 1| 1| 1| 2| 4| 4| 4| 0| 7|             
                                           | 8| 8| 4| 0| 5| 8| 8| 8| 9| 5| 4| 8| 8| 8| 3| 8| 8| 6| 2| 4| 8| 8| 8| 6| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    80 PPM                                 | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
      Alveolar Epithelium, Hyperplasia,    |                                                                          |             
           Focal                           |                                                                          |             
      Alveolar Epithelium, Hyperplasia,    |                                                                          |             
           Multifocal                      |                                     3                                    |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fungus                               |       2                                         3                        |             
      Inflammation, Acute                  |                                                 2                        |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                         +  +                    +                        |             
      Cataract                             |                            3                    3                        |             
      Synechia                             |                                                 4                        |             
      Retina, Degeneration                 |                            4                    4                        |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                         +  +                                             |             
      Inflammation, Chronic                |                            3                                             |             
                                            __________________________________________________________________________|             
   Zymbal's Gland                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Ectasia                              | 2  3  3  2                 2  2  2  3     2     3  3     2        3      |             
      Hyperplasia, Focal                   |                                        3                                 |             
      Hyperplasia, Focal, Squamous         | 1                                                                        |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Infarct, Chronic                     |                            3                                             |             
      Inflammation, Chronic Active         |                                                                   4      |             
      Nephropathy, Chronic                 | 2  1           2  2              2  2  1  2  2     2     1  2  1  2  3   |             
      Cortex, Cyst                         |                                                                          |             
      Medulla, Inflammation, Acute         | 3                                                                        |             
      Renal Tubule, Degeneration, Hyaline  |                         2           3                                    |             
      Renal Tubule, Dilatation             |                                                    2                     |             
      Renal Tubule, Vacuolization          |                                                                          |             
          Cytoplasmic                      |                                                    3                     |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  17                                                               
NTP Experiment-Test: 05172-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                               3,3-DIMETHOXYBENZIDINE DIHYDROCHLORIDE                          Date: 04/30/97  
Route: DOSED WATER                                                                                                Time: 17:38:14  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 6| 6| 4| 3| 6| 6| 6| 6| 4| 6| 6| 5| 5| 5| 6| 6| 6| 5| 4|              |            |
                             DAY ON TEST   | 4| 1| 3| 2| 7| 4| 4| 4| 1| 7| 1| 1| 9| 6| 7| 4| 4| 0| 0| 3|              |            |
                                           | 8| 8| 2| 4| 3| 8| 8| 8| 8| 6| 6| 6| 9| 2| 1| 8| 8| 2| 5| 6|              |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |      T     |
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|              |      A     |
    80 PPM                                 | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|              |      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|              |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  45        |
                                            __________________________________________________________________________|____________|
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  44        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  44        |
      Parasite Metazoan                    |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  44        |
      Parasite Metazoan                    |             1                                                            |      1  1.0|
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  43        |
                                            __________________________________________________________________________|____________|
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +               |  43        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +               |  43        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +               |  43        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +               |  43        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  44        |
      Angiectasis, Focal                   |                                                                          |      1  3.0|
      Basophilic Focus                     | 2  1     2  1  2  3     1  2  1  2        1  2  3  2     1               |     34  1.8|
      Clear Cell Focus                     |    1              2  2     1                                             |     11  1.6|
      Degeneration, Cystic                 |                                           1                              |      2  1.0|
      Eosinophilic Focus                   |                   2  3              3        3                           |      7  2.3|
      Fatty Change                         |                                                                          |      1  3.0|
      Granuloma                            |          1                                3              1               |      3  1.7|
      Hematopoietic Cell Proliferation     | 1  2                 1  1     2        2        1  1     1               |     18  1.5|
      Hepatodiaphragmatic Nodule           |                            X              X     X                        |      6     |
      Necrosis, Multifocal                 |                                                    3                     |      1  3.0|
      Pigmentation                         |                                                                          |      1  1.0|
      Regeneration, Diffuse                |       2                                                                  |      2  2.0|
      Regeneration, Multifocal             |                                     3                                    |      1  3.0|
      Vacuolization Cytoplasmic, Focal     |                                                                          |      1  2.0|
      Bile Duct, Hyperplasia               |                                                                          |      1  2.0|
      Centrilobular, Degeneration, Diffuse |                               1                                          |      2  1.5|
      Centrilobular, Degeneration          |                                                       4                  |      1  4.0|
      Centrilobular, Necrosis, Diffuse     |                                                                          |      1  2.0|
      Centrilobular, Necrosis              |                                     2                                    |      1  2.0|
                                            __________________________________________________________________________|____________|
   Mesentery                               |                                                                          |   1        |
      Fat, Necrosis                        |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +               |  43        |
      Atrophy                              |                      2                                                   |      4  2.3|
                                            __________________________________________________________________________|____________|
   Pharynx                                 |                                                                          |   1        |
      Palate, Hyperkeratosis, Focal        |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +               |  44        |
      Inflammation, Chronic                |                                                                          |      1  4.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  18                                                               
NTP Experiment-Test: 05172-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                               3,3-DIMETHOXYBENZIDINE DIHYDROCHLORIDE                          Date: 04/30/97  
Route: DOSED WATER                                                                                                Time: 17:38:14  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 6| 6| 4| 3| 6| 6| 6| 6| 4| 6| 6| 5| 5| 5| 6| 6| 6| 5| 4|              |            |
                             DAY ON TEST   | 4| 1| 3| 2| 7| 4| 4| 4| 1| 7| 1| 1| 9| 6| 7| 4| 4| 0| 0| 3|              |            |
                                           | 8| 8| 2| 4| 3| 8| 8| 8| 8| 6| 6| 6| 9| 2| 1| 8| 8| 2| 5| 6|              |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |      T     |
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|              |      A     |
    80 PPM                                 | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|              |      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|              |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +               |  44        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +               |  44        |
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +               |  44        |
      Erosion, Focal                       |       1                                                                  |      1  1.0|
                                            __________________________________________________________________________|____________|
   Tongue                                  |                                              +                           |   2        |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  45        |
      Cardiomyopathy, Chronic              |          1     1  2  1                          2        1               |     17  1.4|
      Atrium, Thrombosis                   |       X                                                                  |      1     |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  45        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  45        |
      Degeneration, Focal                  |                   2                                                      |      1  2.0|
      Hyperplasia, Focal                   |                                              2                           |      1  2.0|
      Hypertrophy, Focal                   |                                                 2        1               |      3  1.7|
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  45        |
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +               |  43        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +               |  43        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  45        |
      Pars Distalis, Angiectasis           |       3              3                                                   |      4  3.3|
      Pars Distalis, Cyst                  |    X           X           X        X  X        X                        |     10     |
      Pars Distalis, Hyperplasia, Diffuse  |                                                                          |      2  3.0|
      Pars Distalis, Hyperplasia, Focal    |                                                    2                     |      4  2.3|
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +               |  44        |
      C-Cell, Hyperplasia, Focal           |       2                                                                  |      4  1.8|
      C-Cell, Hyperplasia, Multifocal      |                                              2                           |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Clitoral Gland                          | +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  44        |
      Ectasia                              | 3                 3        2        4  3                                 |     11  3.1|
      Hyperplasia, Focal                   |                            2           2                                 |      4  2.0|
      Hyperplasia, Focal, Squamous         |                   2                                                      |      2  2.0|
      Hyperplasia, Multifocal              |                                                                          |      2  3.0|
      Hyperplasia, Multifocal, Squamous    | 2                                                                        |      1  2.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  19                                                               
NTP Experiment-Test: 05172-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                               3,3-DIMETHOXYBENZIDINE DIHYDROCHLORIDE                          Date: 04/30/97  
Route: DOSED WATER                                                                                                Time: 17:38:14  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 6| 6| 4| 3| 6| 6| 6| 6| 4| 6| 6| 5| 5| 5| 6| 6| 6| 5| 4|              |            |
                             DAY ON TEST   | 4| 1| 3| 2| 7| 4| 4| 4| 1| 7| 1| 1| 9| 6| 7| 4| 4| 0| 0| 3|              |            |
                                           | 8| 8| 2| 4| 3| 8| 8| 8| 8| 6| 6| 6| 9| 2| 1| 8| 8| 2| 5| 6|              |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |      T     |
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|              |      A     |
    80 PPM                                 | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|              |      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|              |            |
 __________________________________________________________________________________________________________________________________ 
 GENITAL SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
      Inflammation, Acute                  | 3                                                                        |      1  3.0|
      Necrosis                             |       4                                                                  |      1  4.0|
                                            __________________________________________________________________________|____________|
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  45        |
      Cyst                                 |    X           X           X        X                                    |      7  2.5|
                                            __________________________________________________________________________|____________|
   Oviduct                                 |                      +                                                   |   1        |
      Thrombosis                           |                      X                                                   |      1     |
                                            __________________________________________________________________________|____________|
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  45        |
      Hydrometra                           |                                                                          |      1  3.0|
      Inflammation, Acute                  |                                                                          |      1  3.0|
      Thrombosis                           |                               X                                          |      1     |
      Bilateral, Hydrometra                |                                                                          |      1  3.0|
      Cervix, Fibrosis                     |                                              2                           |      3  2.0|
      Endometrium, Cyst                    |                                                                          |      2  3.0|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  45        |
      Hyperplasia                          | 2           2                          2        2                        |      8  2.1|
      Myelofibrosis                        |                      3                                                   |      1  3.0|
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  45        |
      Mediastinal, Erythrophagocytosis     |                                                                          |      1  2.0|
      Mediastinal, Infiltration Cellular,  |                                                                          |            |
           Histiocyte                      |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +               |  44        |
      Hyperplasia, Lymphoid                |                                                                          |      3  3.3|
      Hyperplasia, Reticulum Cell          |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  44        |
      Hyperplasia, Reticulum Cell          |                                                                          |      3  3.0|
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +               |  44        |
      Hematopoietic Cell Proliferation     | 3  4     2  3        2        3           3     3  3     2               |     22  2.9|
      Hyperplasia, Reticulum Cell          |                                           3                              |      1  3.0|
      Pigmentation                         |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  M  +               |  41        |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +               |  43        |
      Galactocele                          |                               X                                          |      1     |
      Duct, Ectasia                        |       3                 3        3                                       |      7  3.0|
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  45        |
      Hair Follicle, Hyperplasia, Basal    |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  20                                                               
NTP Experiment-Test: 05172-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                               3,3-DIMETHOXYBENZIDINE DIHYDROCHLORIDE                          Date: 04/30/97  
Route: DOSED WATER                                                                                                Time: 17:38:14  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 6| 6| 4| 3| 6| 6| 6| 6| 4| 6| 6| 5| 5| 5| 6| 6| 6| 5| 4|              |            |
                             DAY ON TEST   | 4| 1| 3| 2| 7| 4| 4| 4| 1| 7| 1| 1| 9| 6| 7| 4| 4| 0| 0| 3|              |            |
                                           | 8| 8| 2| 4| 3| 8| 8| 8| 8| 6| 6| 6| 9| 2| 1| 8| 8| 2| 5| 6|              |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |      T     |
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|              |      A     |
    80 PPM                                 | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|              |      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|              |            |
 __________________________________________________________________________________________________________________________________ 
 INTEGUMENTARY SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
          Cell, Multifocal                 |                                                 2                        |      1  2.0|
      Subcutaneous Tissue, Abscess, Focal  |                                                    4                     |      1  4.0|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    |                               +           +           +                  |   5        |
      Sternum, Osteopetrosis               |                               3           2           3                  |      4  2.8|
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  45        |
      Cerebrum, Compression                |                         X                                                |      2     |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  45        |
      Hyperplasia, Lymphoid                | 2  2     1  2  2     2  2  2     3     3     2  2  2  2  2               |     31  2.1|
      Infiltration Cellular, Histiocyte    |                                                                          |      3  2.0|
      Alveolar Epithelium, Hyperplasia,    |                                                                          |            |
           Focal                           |                                  2                                       |      1  2.0|
      Alveolar Epithelium, Hyperplasia,    |                                                                          |            |
           Multifocal                      |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  45        |
      Fungus                               |                                                                          |      2  2.5|
      Inflammation, Acute                  |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  45        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Eye                                     |                                                                          |   3        |
      Cataract                             |                                                                          |      2  3.0|
      Synechia                             |                                                                          |      1  4.0|
      Retina, Degeneration                 |                                                                          |      2  4.0|
                                            __________________________________________________________________________|____________|
   Harderian Gland                         |                                                                          |   2        |
      Inflammation, Chronic                |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Zymbal's Gland                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  45        |
      Ectasia                              |    2  2           2     2              2  2  2  2                        |     21  2.3|
      Hyperplasia, Focal                   |                                              2                           |      2  2.5|
      Hyperplasia, Focal, Squamous         |                   1                       2                              |      3  1.3|
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  45        |
      Infarct, Chronic                     |                                           3                              |      2  3.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  21                                                               
NTP Experiment-Test: 05172-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                               3,3-DIMETHOXYBENZIDINE DIHYDROCHLORIDE                          Date: 04/30/97  
Route: DOSED WATER                                                                                                Time: 17:38:14  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 6| 6| 4| 3| 6| 6| 6| 6| 4| 6| 6| 5| 5| 5| 6| 6| 6| 5| 4|              |            |
                             DAY ON TEST   | 4| 1| 3| 2| 7| 4| 4| 4| 1| 7| 1| 1| 9| 6| 7| 4| 4| 0| 0| 3|              |            |
                                           | 8| 8| 2| 4| 3| 8| 8| 8| 8| 6| 6| 6| 9| 2| 1| 8| 8| 2| 5| 6|              |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |      T     |
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|              |      A     |
    80 PPM                                 | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|              |      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|              |            |
 __________________________________________________________________________________________________________________________________ 
 URINARY SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
      Inflammation, Chronic Active         |                                                                          |      1  4.0|
      Nephropathy, Chronic                 | 1  1  1  1     3  3  2  2     1           2  2  2        1               |     28  1.8|
      Cortex, Cyst                         |                                           X                              |      1     |
      Medulla, Inflammation, Acute         |                                                                          |      1  3.0|
      Renal Tubule, Degeneration, Hyaline  |                                                                          |      2  2.5|
      Renal Tubule, Dilatation             |                                                                          |      1  2.0|
      Renal Tubule, Vacuolization          |                                                                          |            |
          Cytoplasmic                      |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  45        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  22                                                               
NTP Experiment-Test: 05172-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                               3,3-DIMETHOXYBENZIDINE DIHYDROCHLORIDE                          Date: 04/30/97  
Route: DOSED WATER                                                                                                Time: 17:38:14  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 6| 4| 4| 4| 6| 5| 5| 4| 4| 5| 5| 4| 3| 3| 5| 5| 5| 3| 3| 4| 3| 3| 3| 2|             
                             DAY ON TEST   | 4| 1| 8| 7| 2| 4| 6| 5| 0| 0| 5| 9| 5| 5| 0| 7| 6| 0| 7| 7| 0| 7| 5| 3| 8|             
                                           | 8| 6| 6| 7| 3| 8| 3| 0| 8| 8| 6| 7| 0| 8| 4| 1| 2| 6| 8| 3| 8| 9| 8| 9| 7|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|             
    170 PPM                                | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage, Focal                    |                                                       3                  |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Parasite Metazoan                    |                                                                          |             
      Descending Colon, Hemorrhage, Focal  |                         3                                                |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Parasite Metazoan                    |                            X           X                             1   |             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Basophilic Focus                     | 2  2  2  4  2  2  2  2  2     2  2     2        2     1  1  2     1  1  1|             
      Clear Cell Focus                     |                2           1     2                    1              1   |             
      Degeneration, Cystic, Focal          |                                                                          |             
      Eosinophilic Focus                   |    2           3     3        2  3              2                    2   |             
      Fatty Change                         |                                                                          |             
      Granuloma                            |    2                                                     2     2         |             
      Hematopoietic Cell Proliferation     | 3        2  1        2  1  1     2     2        2  1  1     1           1|             
      Hepatodiaphragmatic Nodule           |                                        X        X  X                 X   |             
      Hepatodiaphragmatic Nodule, Multiple |                                                                          |             
      Necrosis, Coagulative                |                                                                          |             
      Necrosis, Focal                      |                                     3  2  1                              |             
      Necrosis, Multifocal                 |                                                                          |             
      Regeneration, Diffuse                |                                     3                                    |             
      Regeneration, Focal                  |                                                                          |             
      Regeneration, Multifocal             |                                                                          |             
      Vacuolization Cytoplasmic, Diffuse   |                                                                      2   |             
      Vacuolization Cytoplasmic, Multifocal|                                                                          |             
      Bile Duct, Hyperplasia               |                                        2                                 |             
      Centrilobular, Degeneration, Diffuse |    1     1           1                                                   |             
      Centrilobular, Degeneration          |                                                                          |             
      Centrilobular, Necrosis, Diffuse     |                                                                          |             
      Centrilobular, Necrosis              |                                                    3                     |             
                                            __________________________________________________________________________|             
   Mesentery                               |                   +                                                      |             
      Fat, Accessory Spleen                |                                                                          |             
      Fat, Necrosis                        |                   3                                                      |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                      1                                      1            |             
                                            __________________________________________________________________________|             
   Pharynx                                 |                      +                                                   |             
      Mucosa, Palate, Hyperplasia, Focal   |                      3                                                   |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  23                                                               
NTP Experiment-Test: 05172-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                               3,3-DIMETHOXYBENZIDINE DIHYDROCHLORIDE                          Date: 04/30/97  
Route: DOSED WATER                                                                                                Time: 17:38:14  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 6| 4| 4| 4| 6| 5| 5| 4| 4| 5| 5| 4| 3| 3| 5| 5| 5| 3| 3| 4| 3| 3| 3| 2|             
                             DAY ON TEST   | 4| 1| 8| 7| 2| 4| 6| 5| 0| 0| 5| 9| 5| 5| 0| 7| 6| 0| 7| 7| 0| 7| 5| 3| 8|             
                                           | 8| 6| 6| 7| 3| 8| 3| 0| 8| 8| 6| 7| 0| 8| 4| 1| 2| 6| 8| 3| 8| 9| 8| 9| 7|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|             
    170 PPM                                | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
                                           |                                                                          |             
      Atrophy                              |                                                                   2      |             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Acanthosis                           |                                              3                           |             
      Hyperkeratosis                       |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Erosion, Focal                       |                                                                          |             
      Erosion, Multifocal                  |                                                                          |             
      Necrosis, Multifocal                 |                                                                          |             
                                            __________________________________________________________________________|             
   Tongue                                  |             +                       +                                    |             
      Hyperplasia, Focal                   |                                     3                                    |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cardiomyopathy, Chronic              |       1                 1     2  2                    1  1           1   |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Congestion                           |                               2                                          |             
      Ectasia                              |                                                                          |             
      Hyperplasia, Multifocal              |                                                                          |             
      Hypertrophy, Focal                   |                            2                                             |             
      Hypertrophy, Multifocal              |                                                                          |             
      Vacuolization Cytoplasmic, Diffuse   |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hematopoietic Cell Proliferation     |                                                                          |             
      Hyperplasia, Focal                   |                                                                          |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  M  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Pigmentation                         |             2                                                            |             
      Pars Distalis, Angiectasis           |                                                                   2      |             
      Pars Distalis, Cyst                  |                   X              X  X           X        X               |             
      Pars Distalis, Hyperplasia, Focal    |                               2  2              3                        |             
      Pars Distalis, Hyperplasia,          |                                                                          |             
          Multifocal                       |                                                                          |             
      Pars Distalis, Necrosis, Focal       |                                                                          |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      C-Cell, Hyperplasia, Focal           |                                                       1                  |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Tissue NOS                              |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  24                                                               
NTP Experiment-Test: 05172-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                               3,3-DIMETHOXYBENZIDINE DIHYDROCHLORIDE                          Date: 04/30/97  
Route: DOSED WATER                                                                                                Time: 17:38:14  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 6| 4| 4| 4| 6| 5| 5| 4| 4| 5| 5| 4| 3| 3| 5| 5| 5| 3| 3| 4| 3| 3| 3| 2|             
                             DAY ON TEST   | 4| 1| 8| 7| 2| 4| 6| 5| 0| 0| 5| 9| 5| 5| 0| 7| 6| 0| 7| 7| 0| 7| 5| 3| 8|             
                                           | 8| 6| 6| 7| 3| 8| 3| 0| 8| 8| 6| 7| 0| 8| 4| 1| 2| 6| 8| 3| 8| 9| 8| 9| 7|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|             
    170 PPM                                | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Clitoral Gland                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                                                                          |             
      Cyst                                 |                                                                          |             
      Ectasia                              | 3                             3     3        4                           |             
      Hyperplasia, Focal                   |                         2                                2     2     1   |             
      Hyperplasia, Multifocal, Squamous    |                                                                          |             
      Inflammation, Chronic Active         |                                                                          |             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                X                                                         |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrosis                             |                                                                          |             
      Hydrometra                           |       4                                                                  |             
      Cervix, Fibrosis                     |                                                                          |             
      Endometrium, Cyst                    |                                                                2         |             
                                            __________________________________________________________________________|             
   Vagina                                  |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                        2        2     2                  |             
      Myelofibrosis                        |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Mediastinal, Hemorrhage              |                                                                          |             
      Pancreatic, Pigmentation             |                                     3                                    |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Congestion                           |                            2                                             |             
      Hemorrhage                           |                                                                          |             
      Hyperplasia, Lymphoid                |                                                 3              3         |             
      Hyperplasia, Reticulum Cell          |                            2                                             |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                                                                          |             
      Hemorrhage                           |                                     2                                    |             
      Hyperplasia, Lymphoid                |                                                                2         |             
      Hyperplasia, Reticulum Cell          |                            2     2        1           2  2        3  1   |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                                                                          |             
      Hematopoietic Cell Proliferation     | 4  2  3  3           4     3     4     3           4  3           3  2  3|             
      Hemorrhage, Focal                    |                                                                          |             
      Infarct                              |                                                                          |             
      Pigmentation                         |                                                                          |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  M  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                                                                          |             
      Congestion                           |                                                                   2      |             
      Hemorrhage, Focal                    |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  25                                                               
NTP Experiment-Test: 05172-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                               3,3-DIMETHOXYBENZIDINE DIHYDROCHLORIDE                          Date: 04/30/97  
Route: DOSED WATER                                                                                                Time: 17:38:14  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 6| 4| 4| 4| 6| 5| 5| 4| 4| 5| 5| 4| 3| 3| 5| 5| 5| 3| 3| 4| 3| 3| 3| 2|             
                             DAY ON TEST   | 4| 1| 8| 7| 2| 4| 6| 5| 0| 0| 5| 9| 5| 5| 0| 7| 6| 0| 7| 7| 0| 7| 5| 3| 8|             
                                           | 8| 6| 6| 7| 3| 8| 3| 0| 8| 8| 6| 7| 0| 8| 4| 1| 2| 6| 8| 3| 8| 9| 8| 9| 7|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|             
    170 PPM                                | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Duct, Ectasia                        |                                                       2           2      |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    |          +                 +                       +                     |             
      Sternum, Osteopetrosis               |          3                 2                       3                     |             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Meninges, Infiltration Cellular,     |                                                                          |             
           Mononuclear Cell                |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Lymphoid                |       2  3  2  2  2  3  1  2     2     2  2     2  2  2  2  2  2  2  2   |             
      Infiltration Cellular, Histiocyte    |                                                                      1   |             
      Thrombosis                           |                                                                          |             
      Alveolar Epithelium, Hyperplasia,    |                                                                          |             
           Focal                           |                               2                                         1|             
      Alveolus, Pigmentation               |                                                                          |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Acute                  |                                                                          |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |    +                                         +                           |             
      Cataract                             |    4                                                                     |             
      Inflammation, Chronic Active         |                                              4                           |             
      Synechia                             |                                                                          |             
      Cornea, Necrosis                     |                                              4                           |             
      Retina, Degeneration                 |                                                                          |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                                                                          |             
      Inflammation, Chronic                |                                                                          |             
                                            __________________________________________________________________________|             
   Zymbal's Gland                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Ectasia                              | 2                 2                          2        1        3         |             
      Hyperplasia, Focal                   |    1                 1                                                   |             
      Hyperplasia, Focal, Squamous         |                                                                          |             
      Hyperplasia, Multifocal              |                1                                                         |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  26                                                               
NTP Experiment-Test: 05172-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                               3,3-DIMETHOXYBENZIDINE DIHYDROCHLORIDE                          Date: 04/30/97  
Route: DOSED WATER                                                                                                Time: 17:38:14  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 6| 4| 4| 4| 6| 5| 5| 4| 4| 5| 5| 4| 3| 3| 5| 5| 5| 3| 3| 4| 3| 3| 3| 2|             
                             DAY ON TEST   | 4| 1| 8| 7| 2| 4| 6| 5| 0| 0| 5| 9| 5| 5| 0| 7| 6| 0| 7| 7| 0| 7| 5| 3| 8|             
                                           | 8| 6| 6| 7| 3| 8| 3| 0| 8| 8| 6| 7| 0| 8| 4| 1| 2| 6| 8| 3| 8| 9| 8| 9| 7|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|             
    170 PPM                                | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                                                                          |             
      Hydronephrosis                       |                                                                          |             
      Infarct, Chronic                     |          3                                                               |             
      Nephropathy, Chronic                 | 2  1        1  2           1  2  2        1        1  1  2  2  2  1      |             
      Renal Tubule, Pigmentation           |                                                                      1   |             
      Transitional Epithelium, Hyperplasia,|                                                                          |             
           Focal                           |                                  2                                       |             
                                            __________________________________________________________________________|             
   Ureter                                  |                                                                          |             
      Dilatation                           |                                                                          |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  27                                                               
NTP Experiment-Test: 05172-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                               3,3-DIMETHOXYBENZIDINE DIHYDROCHLORIDE                          Date: 04/30/97  
Route: DOSED WATER                                                                                                Time: 17:38:14  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 3| 2| 6| 4| 4| 6| 6| 5| 4| 4| 4| 4| 4| 4| 2| 5| 4| 3| 3| 3| 6| 6| 5| 5| 3|             
                             DAY ON TEST   | 6| 7| 0| 4| 3| 4| 4| 6| 7| 3| 8| 8| 7| 1| 8| 5| 2| 7| 5| 4| 4| 4| 6| 5| 7|             
                                           | 1| 4| 2| 9| 6| 8| 1| 1| 6| 6| 3| 3| 6| 9| 7| 0| 4| 8| 8| 4| 8| 8| 2| 0| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
    170 PPM                                | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage, Focal                    |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Parasite Metazoan                    |                                                    X                     |             
      Descending Colon, Hemorrhage, Focal  |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +|             
      Parasite Metazoan                    |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  A  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  A  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  A  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Basophilic Focus                     | 1     2  1  1     2  2  1  3  1  3  2     1     1  1     1  2  3  2     1|             
      Clear Cell Focus                     |             1        2                          2           1  2        1|             
      Degeneration, Cystic, Focal          |                                                                          |             
      Eosinophilic Focus                   |       3     1     2  2  2                       2                        |             
      Fatty Change                         |                            3           4                                 |             
      Granuloma                            |                   3     2                                                |             
      Hematopoietic Cell Proliferation     | 1     2  2  2        2  1  1     2  1     1        1  1  1        2  1  1|             
      Hepatodiaphragmatic Nodule           |                                                                          |             
      Hepatodiaphragmatic Nodule, Multiple |                   X                                                      |             
      Necrosis, Coagulative                |                      4                                                   |             
      Necrosis, Focal                      |                2                                                         |             
      Necrosis, Multifocal                 |                                                                      1   |             
      Regeneration, Diffuse                |                                        3                                 |             
      Regeneration, Focal                  |                                              2                           |             
      Regeneration, Multifocal             |                4                                                         |             
      Vacuolization Cytoplasmic, Diffuse   |                                                                         2|             
      Vacuolization Cytoplasmic, Multifocal|             2                                                            |             
      Bile Duct, Hyperplasia               |                   2                                                      |             
      Centrilobular, Degeneration, Diffuse |                            2              2                              |             
      Centrilobular, Degeneration          |                                                                          |             
      Centrilobular, Necrosis, Diffuse     | 1        2                             4                                 |             
      Centrilobular, Necrosis              |                                                                          |             
                                            __________________________________________________________________________|             
   Mesentery                               |                                                          +              +|             
      Fat, Accessory Spleen                |                                                                         X|             
      Fat, Necrosis                        |                                                          2               |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                                                             2            |             
                                            __________________________________________________________________________|             
   Pharynx                                 |                   +           +                                          |             
      Mucosa, Palate, Hyperplasia, Focal   |                               3                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  28                                                               
NTP Experiment-Test: 05172-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                               3,3-DIMETHOXYBENZIDINE DIHYDROCHLORIDE                          Date: 04/30/97  
Route: DOSED WATER                                                                                                Time: 17:38:14  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 3| 2| 6| 4| 4| 6| 6| 5| 4| 4| 4| 4| 4| 4| 2| 5| 4| 3| 3| 3| 6| 6| 5| 5| 3|             
                             DAY ON TEST   | 6| 7| 0| 4| 3| 4| 4| 6| 7| 3| 8| 8| 7| 1| 8| 5| 2| 7| 5| 4| 4| 4| 6| 5| 7|             
                                           | 1| 4| 2| 9| 6| 8| 1| 1| 6| 6| 3| 3| 6| 9| 7| 0| 4| 8| 8| 4| 8| 8| 2| 0| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
    170 PPM                                | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
                                           |                                                                          |             
      Atrophy                              |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    |    +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Acanthosis                           |                                                                      2   |             
      Hyperkeratosis                       |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Erosion, Focal                       |                                                                          |             
      Erosion, Multifocal                  |                                                                          |             
      Necrosis, Multifocal                 | 3                                                                        |             
                                            __________________________________________________________________________|             
   Tongue                                  |                                                                          |             
      Hyperplasia, Focal                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cardiomyopathy, Chronic              | 2           1  2     2  2              1           1        2  2         |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Congestion                           |                                                                          |             
      Ectasia                              |       2                                                                  |             
      Hyperplasia, Multifocal              |                                                                2         |             
      Hypertrophy, Focal                   |                                                                          |             
      Hypertrophy, Multifocal              |                                                                2         |             
      Vacuolization Cytoplasmic, Diffuse   |                                        3                                 |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +|             
      Hematopoietic Cell Proliferation     |                                                                          |             
      Hyperplasia, Focal                   |       1                                                                  |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Pigmentation                         |                                                                          |             
      Pars Distalis, Angiectasis           | 2                                                                        |             
      Pars Distalis, Cyst                  |       X              X              X              X     X     X     X  X|             
      Pars Distalis, Hyperplasia, Focal    | 2                                      2                                 |             
      Pars Distalis, Hyperplasia,          |                                                                          |             
          Multifocal                       |                                                                          |             
      Pars Distalis, Necrosis, Focal       |                                        1                                 |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      C-Cell, Hyperplasia, Focal           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Tissue NOS                              |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  29                                                               
NTP Experiment-Test: 05172-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                               3,3-DIMETHOXYBENZIDINE DIHYDROCHLORIDE                          Date: 04/30/97  
Route: DOSED WATER                                                                                                Time: 17:38:14  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 3| 2| 6| 4| 4| 6| 6| 5| 4| 4| 4| 4| 4| 4| 2| 5| 4| 3| 3| 3| 6| 6| 5| 5| 3|             
                             DAY ON TEST   | 6| 7| 0| 4| 3| 4| 4| 6| 7| 3| 8| 8| 7| 1| 8| 5| 2| 7| 5| 4| 4| 4| 6| 5| 7|             
                                           | 1| 4| 2| 9| 6| 8| 1| 1| 6| 6| 3| 3| 6| 9| 7| 0| 4| 8| 8| 4| 8| 8| 2| 0| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
    170 PPM                                | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Clitoral Gland                          | +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                                                                          |             
      Cyst                                 |                                                                          |             
      Ectasia                              |                            3  3                             2  3         |             
      Hyperplasia, Focal                   |                         2                                                |             
      Hyperplasia, Multifocal, Squamous    |                                                             1            |             
      Inflammation, Chronic Active         |    1                                                                     |             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                     3                                    |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrosis                             |    2                                3                                    |             
      Hydrometra                           |    3                                         3                           |             
      Cervix, Fibrosis                     |                                                             2            |             
      Endometrium, Cyst                    |    3           X                                                     3   |             
                                            __________________________________________________________________________|             
   Vagina                                  |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                  2                 2                     |             
      Myelofibrosis                        |                3                                                         |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Mediastinal, Hemorrhage              |                                                                          |             
      Pancreatic, Pigmentation             |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Congestion                           |    2                                                                     |             
      Hemorrhage                           |                                                                          |             
      Hyperplasia, Lymphoid                |                   4                                                      |             
      Hyperplasia, Reticulum Cell          |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                                                                          |             
      Hemorrhage                           |                                                                          |             
      Hyperplasia, Lymphoid                |                                                                          |             
      Hyperplasia, Reticulum Cell          | 2  1                                               2  2  2               |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                                                                          |             
      Hematopoietic Cell Proliferation     | 3     3  4  3        3  3  4     3  3     3     2  3  3  2     2  4     3|             
      Hemorrhage, Focal                    |                                                                          |             
      Infarct                              |                                                       3                  |             
      Pigmentation                         |                                                                          |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  +  +  M  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                                                                          |             
      Congestion                           |                                                                          |             
      Hemorrhage, Focal                    |          2                             2                                 |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  30                                                               
NTP Experiment-Test: 05172-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                               3,3-DIMETHOXYBENZIDINE DIHYDROCHLORIDE                          Date: 04/30/97  
Route: DOSED WATER                                                                                                Time: 17:38:14  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 3| 2| 6| 4| 4| 6| 6| 5| 4| 4| 4| 4| 4| 4| 2| 5| 4| 3| 3| 3| 6| 6| 5| 5| 3|             
                             DAY ON TEST   | 6| 7| 0| 4| 3| 4| 4| 6| 7| 3| 8| 8| 7| 1| 8| 5| 2| 7| 5| 4| 4| 4| 6| 5| 7|             
                                           | 1| 4| 2| 9| 6| 8| 1| 1| 6| 6| 3| 3| 6| 9| 7| 0| 4| 8| 8| 4| 8| 8| 2| 0| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
    170 PPM                                | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Duct, Ectasia                        | 2              3        3                    3                 3         |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    |          +  +              +           +                                 |             
      Sternum, Osteopetrosis               |          3  3              4                                             |             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |                                              +                           |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Meninges, Infiltration Cellular,     |                                                                          |             
           Mononuclear Cell                |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Lymphoid                | 2  2  2  2  1     2  3  2  2  2  2  2  2  2     2  2  2  2     2  2  3  2|             
      Infiltration Cellular, Histiocyte    |                            2                                             |             
      Thrombosis                           | 1                                                                        |             
      Alveolar Epithelium, Hyperplasia,    |                                                                          |             
           Focal                           |       3                                            1                     |             
      Alveolus, Pigmentation               | 1                                         2                              |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Acute                  |                                                                          |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                                                       +                  |             
      Cataract                             |                                                       3                  |             
      Inflammation, Chronic Active         |                                                                          |             
      Synechia                             |                                                       2                  |             
      Cornea, Necrosis                     |                                                                          |             
      Retina, Degeneration                 |                                                       3                  |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                                                                          |             
      Inflammation, Chronic                |                                                                          |             
                                            __________________________________________________________________________|             
   Zymbal's Gland                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Ectasia                              |    2     2  1  2     3  1     2     3  2                 2  2     2  4   |             
      Hyperplasia, Focal                   |                                                          2        2     2|             
      Hyperplasia, Focal, Squamous         |                   2           1                    1           1     2   |             
      Hyperplasia, Multifocal              |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  31                                                               
NTP Experiment-Test: 05172-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                               3,3-DIMETHOXYBENZIDINE DIHYDROCHLORIDE                          Date: 04/30/97  
Route: DOSED WATER                                                                                                Time: 17:38:14  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 3| 2| 6| 4| 4| 6| 6| 5| 4| 4| 4| 4| 4| 4| 2| 5| 4| 3| 3| 3| 6| 6| 5| 5| 3|             
                             DAY ON TEST   | 6| 7| 0| 4| 3| 4| 4| 6| 7| 3| 8| 8| 7| 1| 8| 5| 2| 7| 5| 4| 4| 4| 6| 5| 7|             
                                           | 1| 4| 2| 9| 6| 8| 1| 1| 6| 6| 3| 3| 6| 9| 7| 0| 4| 8| 8| 4| 8| 8| 2| 0| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
    170 PPM                                | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                                                                          |             
      Hydronephrosis                       |                                                                          |             
      Infarct, Chronic                     |                                                                          |             
      Nephropathy, Chronic                 |    1        1  2  2           1     1  2     1  1  1     1  2  2  1  2   |             
      Renal Tubule, Pigmentation           |                                              3     1                     |             
      Transitional Epithelium, Hyperplasia,|                                                                          |             
           Focal                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ureter                                  |                                                                          |             
      Dilatation                           |                                                                          |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  32                                                               
NTP Experiment-Test: 05172-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                               3,3-DIMETHOXYBENZIDINE DIHYDROCHLORIDE                          Date: 04/30/97  
Route: DOSED WATER                                                                                                Time: 17:38:14  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 5| 4| 4| 3| 6| 5| 5| 4| 3| 5| 5| 4| 4| 3| 5| 4| 3| 3| 2| 5| 5| 4| 3| 3|            |
                             DAY ON TEST   | 1| 5| 8| 3| 0| 4| 6| 3| 6| 3| 2| 0| 8| 5| 0| 0| 6| 5| 3| 2| 8| 6| 2| 3| 3|            |
                                           | 6| 0| 3| 6| 9| 8| 3| 3| 5| 9| 7| 1| 3| 0| 4| 5| 8| 4| 1| 0| 3| 4| 4| 9| 3|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|      A     |
    170 PPM                                | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  75        |
                                            __________________________________________________________________________|____________|
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  75        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  75        |
      Hemorrhage, Focal                    |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  75        |
      Parasite Metazoan                    |                                                                          |      1     |
      Descending Colon, Hemorrhage, Focal  |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  74        |
      Parasite Metazoan                    |                                                                          |      3  1.0|
                                            __________________________________________________________________________|____________|
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +|  73        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  73        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +|  72        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +|  72        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  75        |
      Basophilic Focus                     | 1  1  1  2     2  2  1        1     1  1           1  1  1  3     2     4|     54  1.7|
      Clear Cell Focus                     | 2        1     1  1        2  2                                      1   |     18  1.4|
      Degeneration, Cystic, Focal          |                                                                3         |      1  3.0|
      Eosinophilic Focus                   | 3  3        1                 2     2  2                    2            |     20  2.2|
      Fatty Change                         |                         2                                               2|      4  2.8|
      Granuloma                            |                   2                    2                                 |      7  2.1|
      Hematopoietic Cell Proliferation     | 1  2  2  1        1  1     1  2  1  2     1           1  1  2            |     43  1.4|
      Hepatodiaphragmatic Nodule           |                                                                          |      4     |
      Hepatodiaphragmatic Nodule, Multiple |                                                                          |      1     |
      Necrosis, Coagulative                |                                                                          |      1  4.0|
      Necrosis, Focal                      |                                                       1                  |      5  1.8|
      Necrosis, Multifocal                 |                                                                          |      1  1.0|
      Regeneration, Diffuse                |                                                                          |      2  3.0|
      Regeneration, Focal                  |                                                                          |      1  2.0|
      Regeneration, Multifocal             |                                                                3         |      2  3.5|
      Vacuolization Cytoplasmic, Diffuse   |                                                                      2   |      3  2.0|
      Vacuolization Cytoplasmic, Multifocal|                                                                          |      1  2.0|
      Bile Duct, Hyperplasia               |                                                                          |      2  2.0|
      Centrilobular, Degeneration, Diffuse |    2                 4                                                   |      7  1.9|
      Centrilobular, Degeneration          |                                                             2            |      1  2.0|
      Centrilobular, Necrosis, Diffuse     |                                  2                       2               |      5  2.2|
      Centrilobular, Necrosis              |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Mesentery                               |             +                                         +     +     +  +   |   8        |
      Fat, Accessory Spleen                |                                                                          |      1     |
      Fat, Necrosis                        |                                                       2     3        3   |      5  2.6|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  33                                                               
NTP Experiment-Test: 05172-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                               3,3-DIMETHOXYBENZIDINE DIHYDROCHLORIDE                          Date: 04/30/97  
Route: DOSED WATER                                                                                                Time: 17:38:14  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 5| 4| 4| 3| 6| 5| 5| 4| 3| 5| 5| 4| 4| 3| 5| 4| 3| 3| 2| 5| 5| 4| 3| 3|            |
                             DAY ON TEST   | 1| 5| 8| 3| 0| 4| 6| 3| 6| 3| 2| 0| 8| 5| 0| 0| 6| 5| 3| 2| 8| 6| 2| 3| 3|            |
                                           | 6| 0| 3| 6| 9| 8| 3| 3| 5| 9| 7| 1| 3| 0| 4| 5| 8| 4| 1| 0| 3| 4| 4| 9| 3|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|      A     |
    170 PPM                                | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  75        |
      Atrophy                              |                   2                                                      |      4  1.5|
                                            __________________________________________________________________________|____________|
   Pharynx                                 |                   +                    +              +                  |   6        |
      Mucosa, Palate, Hyperplasia, Focal   |                                                                          |      2  3.0|
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  75        |
      Atrophy                              |                         3                                                |      2  2.5|
                                            __________________________________________________________________________|____________|
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  75        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  74        |
      Acanthosis                           |                                                                         3|      3  2.7|
      Hyperkeratosis                       |                                                                         2|      1  2.0|
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  75        |
      Erosion, Focal                       |                         2                                                |      1  2.0|
      Erosion, Multifocal                  |                      1                                                   |      1  1.0|
      Necrosis, Multifocal                 |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Tongue                                  |                                              +                 +        +|   5        |
      Hyperplasia, Focal                   |                                                                         3|      2  3.0|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  75        |
      Cardiomyopathy, Chronic              |                            1           2        2  1                 1   |     21  1.5|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  75        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  75        |
      Congestion                           |                                                                          |      1  2.0|
      Ectasia                              |                                                                          |      1  2.0|
      Hyperplasia, Multifocal              |                                                                          |      1  2.0|
      Hypertrophy, Focal                   |                                                                          |      1  2.0|
      Hypertrophy, Multifocal              |                                                                          |      1  2.0|
      Vacuolization Cytoplasmic, Diffuse   |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  74        |
      Hematopoietic Cell Proliferation     |                                     2                                    |      1  2.0|
      Hyperplasia, Focal                   |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  75        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  M  +  +|  70        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  75        |
      Pigmentation                         |                                                                          |      1  2.0|
      Pars Distalis, Angiectasis           |                2                                                         |      3  2.0|
      Pars Distalis, Cyst                  |    X  X           X                 X                                    |     17     |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  34                                                               
NTP Experiment-Test: 05172-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                               3,3-DIMETHOXYBENZIDINE DIHYDROCHLORIDE                          Date: 04/30/97  
Route: DOSED WATER                                                                                                Time: 17:38:14  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 5| 4| 4| 3| 6| 5| 5| 4| 3| 5| 5| 4| 4| 3| 5| 4| 3| 3| 2| 5| 5| 4| 3| 3|            |
                             DAY ON TEST   | 1| 5| 8| 3| 0| 4| 6| 3| 6| 3| 2| 0| 8| 5| 0| 0| 6| 5| 3| 2| 8| 6| 2| 3| 3|            |
                                           | 6| 0| 3| 6| 9| 8| 3| 3| 5| 9| 7| 1| 3| 0| 4| 5| 8| 4| 1| 0| 3| 4| 4| 9| 3|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|      A     |
    170 PPM                                | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
                                           |                                                                          |            |
      Pars Distalis, Hyperplasia, Focal    |                2                                               2         |      7  2.1|
      Pars Distalis, Hyperplasia,          |                                                                          |            |
          Multifocal                       |                                                             2            |      1  2.0|
      Pars Distalis, Necrosis, Focal       |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  75        |
      C-Cell, Hyperplasia, Focal           |                                                                          |      1  1.0|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Tissue NOS                              |                                                                   +      |   1        |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Clitoral Gland                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  74        |
      Atrophy                              |             2                                                           2|      2  2.0|
      Cyst                                 |                                                                         2|      1  2.0|
      Ectasia                              |                      4                       4  3                        |     11  3.2|
      Hyperplasia, Focal                   |                                                    1  2                  |      7  1.7|
      Hyperplasia, Multifocal, Squamous    |                                                                          |      1  1.0|
      Inflammation, Chronic Active         |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  75        |
      Cyst                                 |                                                 X              X         |      4  3.0|
                                            __________________________________________________________________________|____________|
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  75        |
      Fibrosis                             |                                                                          |      2  2.5|
      Hydrometra                           |                                                                   3      |      4  3.3|
      Cervix, Fibrosis                     |                                                                          |      1  2.0|
      Endometrium, Cyst                    |       3                 3                                                |      6  2.8|
                                            __________________________________________________________________________|____________|
   Vagina                                  |                                                                         +|   1        |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  75        |
      Hyperplasia                          | 2                             2                       2              2   |      9  2.0|
      Myelofibrosis                        |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  75        |
      Mediastinal, Hemorrhage              |                                  3                                       |      1  3.0|
      Pancreatic, Pigmentation             |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +|  74        |
      Congestion                           |                                           2                              |      3  2.0|
      Hemorrhage                           |                                  3                                       |      1  3.0|
      Hyperplasia, Lymphoid                |                                                                          |      3  3.3|
      Hyperplasia, Reticulum Cell          |                                                                          |      1  2.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  35                                                               
NTP Experiment-Test: 05172-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                               3,3-DIMETHOXYBENZIDINE DIHYDROCHLORIDE                          Date: 04/30/97  
Route: DOSED WATER                                                                                                Time: 17:38:14  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 5| 4| 4| 3| 6| 5| 5| 4| 3| 5| 5| 4| 4| 3| 5| 4| 3| 3| 2| 5| 5| 4| 3| 3|            |
                             DAY ON TEST   | 1| 5| 8| 3| 0| 4| 6| 3| 6| 3| 2| 0| 8| 5| 0| 0| 6| 5| 3| 2| 8| 6| 2| 3| 3|            |
                                           | 6| 0| 3| 6| 9| 8| 3| 3| 5| 9| 7| 1| 3| 0| 4| 5| 8| 4| 1| 0| 3| 4| 4| 9| 3|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|      A     |
    170 PPM                                | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  75        |
      Atrophy                              |             3                                                            |      1  3.0|
      Hemorrhage                           |                                                                          |      1  2.0|
      Hyperplasia, Lymphoid                |                                                                          |      1  2.0|
      Hyperplasia, Reticulum Cell          |          3  1              2              2           2  2               |     18  1.9|
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  75        |
      Atrophy                              |                                              3                           |      1  3.0|
      Hematopoietic Cell Proliferation     | 2  4  4  3        3  4  2  3  3  3  4  2  3        2  3  3  3     3  3  3|     50  3.0|
      Hemorrhage, Focal                    |                                                                      2   |      1  2.0|
      Infarct                              |                                                                          |      1  3.0|
      Pigmentation                         |                                              3                           |      1  3.0|
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  M  +  +  +  +  +  +  +  +  +  M  +  +  +  M  +  +  +  +  +  +  +  +  +|  68        |
      Atrophy                              |             3                                                            |      1  3.0|
      Congestion                           |                                                                          |      1  2.0|
      Hemorrhage, Focal                    |                                                                          |      2  2.0|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  75        |
      Duct, Ectasia                        |       3                       3                 3     2              3   |     12  2.7|
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  75        |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    |                      +                                                   |   8        |
      Sternum, Osteopetrosis               |                      4                                                   |      7  3.1|
                                            __________________________________________________________________________|____________|
   Skeletal Muscle                         |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  75        |
      Meninges, Infiltration Cellular,     |                                                                          |            |
           Mononuclear Cell                |                2                                                         |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  75        |
      Hyperplasia, Lymphoid                | 2  2     2  2  2  2  2     2  2     2  2  2     2  2     2  2  2     2  2|     60  2.0|
      Infiltration Cellular, Histiocyte    |                            2                       1                     |      4  1.5|
      Thrombosis                           |                                                                          |      1  1.0|
      Alveolar Epithelium, Hyperplasia,    |                                                                          |            |
           Focal                           |                                     1                                    |      5  1.6|
      Alveolus, Pigmentation               |                                                                          |      2  1.5|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  36                                                               
NTP Experiment-Test: 05172-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                               3,3-DIMETHOXYBENZIDINE DIHYDROCHLORIDE                          Date: 04/30/97  
Route: DOSED WATER                                                                                                Time: 17:38:14  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 5| 4| 4| 3| 6| 5| 5| 4| 3| 5| 5| 4| 4| 3| 5| 4| 3| 3| 2| 5| 5| 4| 3| 3|            |
                             DAY ON TEST   | 1| 5| 8| 3| 0| 4| 6| 3| 6| 3| 2| 0| 8| 5| 0| 0| 6| 5| 3| 2| 8| 6| 2| 3| 3|            |
                                           | 6| 0| 3| 6| 9| 8| 3| 3| 5| 9| 7| 1| 3| 0| 4| 5| 8| 4| 1| 0| 3| 4| 4| 9| 3|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|      A     |
    170 PPM                                | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 RESPIRATORY SYSTEM - cont                 |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  75        |
      Inflammation, Acute                  |    2                                               2                     |      2  2.0|
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  75        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Eye                                     |                                                    +        +            |   5        |
      Cataract                             |                                                    2                     |      3  3.0|
      Inflammation, Chronic Active         |                                                                          |      1  4.0|
      Synechia                             |                                                                          |      1  2.0|
      Cornea, Necrosis                     |                                                                          |      1  4.0|
      Retina, Degeneration                 |                                                    3        3            |      3  3.0|
                                            __________________________________________________________________________|____________|
   Harderian Gland                         |                                                    +                     |   1        |
      Inflammation, Chronic                |                                                    3                     |      1  3.0|
                                            __________________________________________________________________________|____________|
   Zymbal's Gland                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  75        |
      Ectasia                              |       2  2              1     3     3  3     2  2     2     2           2|     29  2.1|
      Hyperplasia, Focal                   |                            2                                             |      6  1.7|
      Hyperplasia, Focal, Squamous         | 1                                                           2            |      7  1.4|
      Hyperplasia, Multifocal              |                                                                          |      1  1.0|
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  75        |
      Atrophy                              |             3                                                            |      1  3.0|
      Hydronephrosis                       |             3                                               2     4      |      3  3.0|
      Infarct, Chronic                     |                                                                          |      1  3.0|
      Nephropathy, Chronic                 | 1              1  1     1        2  2           2  1                 1   |     38  1.4|
      Renal Tubule, Pigmentation           |             1                             1                              |      5  1.4|
      Transitional Epithelium, Hyperplasia,|                                                                          |            |
           Focal                           |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Ureter                                  |             +                                                     +      |   2        |
      Dilatation                           |             3                                                     4      |      2  3.5|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  75        |
      Hemorrhage                           |                                                             3            |      1  3.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  37                                                               
NTP Experiment-Test: 05172-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                               3,3-DIMETHOXYBENZIDINE DIHYDROCHLORIDE                          Date: 04/30/97  
Route: DOSED WATER                                                                                                Time: 17:38:14  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 4| 4| 3| 3| 3| 6| 4| 3| 2| 2| 4| 4| 4| 3| 3|             
                             DAY ON TEST   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 5| 9| 5| 3| 1| 2| 6| 6| 5| 3| 0| 0| 7| 4|             
                                           | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 2| 5| 8| 9| 0| 4| 3| 2| 1| 1| 8| 8| 8| 4|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|             
    330 PPM                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               |                               +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large                         |                               +  +  +  +  +  +  +  +  +  A  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  |                               +  +  +  +  +  +  +  +  +  A  +  +  +  +  +|             
      Hemorrhage, Focal                    |                                              4                           |             
      Submucosa, Inflammation, Acute       |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  |                               +  +  +  +  +  +  +  +  +  A  +  +  +  +  +|             
      Parasite Metazoan                    |                                  X                                       |             
      Muscularis, Mineralization           |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 |                               +  +  +  +  +  +  +  +  +  A  +  +  +  +  +|             
      Parasite Metazoan                    |                                        1                                 |             
                                            __________________________________________________________________________|             
   Intestine Small                         |                               +  +  +  +  +  +  +  +  +  A  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               |                               +  +  +  +  +  +  +  +  +  A  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  |                               +  +  +  +  +  +  +  +  +  A  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                |                               +  +  +  +  +  +  +  +  +  A  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Liver                                   |                               +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Basophilic Focus                     |                               1  3     1  1  4  3           2  3  1  1  1|             
      Clear Cell Focus                     |                                           1  1                 4     1  1|             
      Cyst                                 |                                                                          |             
      Degeneration, Cystic, Focal          |                                              1                 2         |             
      Degeneration, Cystic                 |                                                                          |             
      Eosinophilic Focus                   |                                        1  1  2              2  2     1  2|             
      Fatty Change                         |                                                                          |             
      Granuloma                            |                               2                       1                  |             
      Hematopoietic Cell Proliferation     |                               2     1  1  1  2  1              2     1  1|             
      Hepatodiaphragmatic Nodule           |                                                          X               |             
      Necrosis, Coagulative                |                                           4                              |             
      Necrosis, Focal                      |                                        1     2     2     1               |             
      Necrosis, Multifocal                 |                                                                          |             
      Regeneration, Diffuse                |                                                                          |             
      Regeneration, Multifocal             |                                              3                           |             
      Thrombosis                           |                                                                          |             
      Vacuolization Cytoplasmic, Diffuse   |                                                                          |             
      Vacuolization Cytoplasmic, Focal     |                                                                          |             
      Bile Duct, Inflammation, Chronic     |                                                                          |             
      Centrilobular, Degeneration, Diffuse |                                                                          |             
      Centrilobular, Degeneration          |                                                                          |             
      Centrilobular, Necrosis, Diffuse     |                                                                          |             
      Kupffer Cell, Pigmentation           |                                                                          |             
                                            __________________________________________________________________________|             
   Mesentery                               |                                              +     +                     |             
      Fat, Necrosis                        |                                              3                           |             
                                            __________________________________________________________________________|             
   Pancreas                                |                               +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage, Focal                    |                                                                          |             
                                            __________________________________________________________________________|             
   Pharynx                                 |                                                                          |             
      Mucosa, Palate, Hyperplasia, Focal   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  38                                                               
NTP Experiment-Test: 05172-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                               3,3-DIMETHOXYBENZIDINE DIHYDROCHLORIDE                          Date: 04/30/97  
Route: DOSED WATER                                                                                                Time: 17:38:14  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 4| 4| 3| 3| 3| 6| 4| 3| 2| 2| 4| 4| 4| 3| 3|             
                             DAY ON TEST   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 5| 9| 5| 3| 1| 2| 6| 6| 5| 3| 0| 0| 7| 4|             
                                           | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 2| 5| 8| 9| 0| 4| 3| 2| 1| 1| 8| 8| 8| 4|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|             
    330 PPM                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         |                               +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach                                 |                               +  +  +  +  +  +  +  +  +  A  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    |                               +  +  +  +  +  +  +  +  +  A  +  +  +  +  +|             
      Acanthosis                           |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      |                               +  +  +  +  +  +  +  +  +  A  +  +  +  +  +|             
      Erosion, Focal                       |                                     1              3                     |             
      Inflammation, Acute                  |                                                                          |             
      Mineralization                       |                                                                          |             
                                            __________________________________________________________________________|             
   Tongue                                  |                                                             +            |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   |                               +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cardiomyopathy, Chronic              |                                     1           1                 1     1|             
      Artery, Mineralization, Multifocal   |                                                                          |             
      Atrium, Thrombosis                   |                                                                          |             
      Epicardium, Inflammation, Chronic    |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           |                               +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   |                               +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hematopoietic Cell Proliferation     |                                                                          |             
      Hypertrophy, Focal                   |                                                                          |             
      Infiltration Cellular, Lymphocyte    |                                                                          |             
      Necrosis, Focal                      |                                                                          |             
      Vacuolization Cytoplasmic, Diffuse   |                                                       2                  |             
      Vacuolization Cytoplasmic, Focal     |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  |                               +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hematopoietic Cell Proliferation     |                                                                          |             
      Hyperplasia, Focal                   |                                                                          |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      |                               +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       |                               +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                                                          |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         |                               +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Pars Distalis, Angiectasis           |                                                                          |             
      Pars Distalis, Cyst                  |                                        X  X                 X     X  X  X|             
      Pars Distalis, Hyperplasia, Focal    |                                                                          |             
      Pars Distalis, Necrosis, Focal       |                                                                          |             
      Pars Distalis, Pigmentation, Focal   |                                                                          |             
      Pars Intermedia, Cyst                |                                                                          |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           |                               +  +  +  +  +  +  +  +  +  A  +  +  +  +  +|             
      C-Cell, Hyperplasia, Focal           |                                              1                           |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  39                                                               
NTP Experiment-Test: 05172-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                               3,3-DIMETHOXYBENZIDINE DIHYDROCHLORIDE                          Date: 04/30/97  
Route: DOSED WATER                                                                                                Time: 17:38:14  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 4| 4| 3| 3| 3| 6| 4| 3| 2| 2| 4| 4| 4| 3| 3|             
                             DAY ON TEST   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 5| 9| 5| 3| 1| 2| 6| 6| 5| 3| 0| 0| 7| 4|             
                                           | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 2| 5| 8| 9| 0| 4| 3| 2| 1| 1| 8| 8| 8| 4|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|             
    330 PPM                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Clitoral Gland                          |                               +  +  M  +  +  +  +  +  +  M  +  +  +  +  +|             
      Atrophy                              |                                                    2                     |             
      Ectasia                              |                                                    2                 2   |             
      Hyperplasia, Focal                   |                                                                         2|             
      Hyperplasia, Focal, Squamous         |                                  3                                       |             
                                            __________________________________________________________________________|             
   Ovary                                   |                               +  +  +  +  +  +  +  +  +  A  +  +  +  +  +|             
      Cyst                                 |                                                                          |             
                                            __________________________________________________________________________|             
   Uterus                                  |                               +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hydrometra                           |                                                                      2   |             
      Endometrium, Cyst                    |                                                 2           2            |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             |                               +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                                    2           2         |             
                                            __________________________________________________________________________|             
   Lymph Node                              |                               +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Axillary, Hyperplasia, Lymphoid      |                                                                          |             
      Mediastinal, Congestion              |                                                                          |             
      Mediastinal, Hemorrhage              |                                                                          |             
      Mediastinal, Hyperplasia, Lymphoid   |                                        2     3                           |             
      Mediastinal, Infiltration Cellular,  |                                                                          |             
           Histiocyte                      |                                                                          |             
      Pancreatic, Congestion               |                                                                          |             
      Pancreatic, Hyperplasia, Lymphoid    |                                              3                           |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  |                               +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |                                                                          |             
      Hyperplasia, Lymphoid                |                                                                   2      |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  |                               +  +  +  +  +  +  +  +  +  A  +  +  +  +  +|             
      Atrophy                              |                                                                          |             
      Erythrophagocytosis                  |                                              3                           |             
      Hyperplasia, Reticulum Cell          |                                     2  3  2                          3   |             
                                            __________________________________________________________________________|             
   Spleen                                  |                               +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                                                    4        2            |             
      Hematopoietic Cell Proliferation     |                               3  2  3  3     3  4     2  2     4     3  3|             
      Pigmentation                         |                                                                          |             
                                            __________________________________________________________________________|             
   Thymus                                  |                               +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           |                               +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Galactocele                          |                                                                          |             
      Duct, Ectasia                        |                                                                2         |             
                                            __________________________________________________________________________|             
   Skin                                    |                               +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Acanthosis                           |                                                                          |             
      Inflammation, Chronic                |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  40                                                               
NTP Experiment-Test: 05172-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                               3,3-DIMETHOXYBENZIDINE DIHYDROCHLORIDE                          Date: 04/30/97  
Route: DOSED WATER                                                                                                Time: 17:38:14  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 4| 4| 3| 3| 3| 6| 4| 3| 2| 2| 4| 4| 4| 3| 3|             
                             DAY ON TEST   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 5| 9| 5| 3| 1| 2| 6| 6| 5| 3| 0| 0| 7| 4|             
                                           | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 2| 5| 8| 9| 0| 4| 3| 2| 1| 1| 8| 8| 8| 4|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|             
    330 PPM                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM - cont             |                                                                          |             
                                           |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    |                                                                          |             
      Sternum, Osteopetrosis               |                                                                          |             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |                                                    +                     |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   |                               +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cerebrum, Necrosis, Focal            |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    |                               +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Congestion                           |                                                                          |             
      Foreign Body                         |                                                             2            |             
      Hyperplasia, Lymphoid                |                               2  2  2  2  2  2  2     2  2     2  2  2  2|             
      Infiltration Cellular, Histiocyte    |                                  2                             2     1   |             
      Inflammation, Acute, Multifocal      |                                                             4            |             
      Inflammation, Focal, Suppurative     |                                                                          |             
      Parasite Metazoan                    |                                                                          |             
      Alveolar Epithelium, Hyperplasia,    |                                                                          |             
           Focal                           |                                                                          |             
      Bronchiole, Hyperplasia, Multifocal  |                                                             1            |             
                                            __________________________________________________________________________|             
   Nose                                    |                               +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fungus                               |                                                                          |             
      Hyperkeratosis, Focal                |                                                                          |             
      Inflammation, Chronic                |                                                                          |             
                                            __________________________________________________________________________|             
   Trachea                                 |                               +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                                                                          |             
      Inflammation, Chronic                |                                                                          |             
                                            __________________________________________________________________________|             
   Zymbal's Gland                          |                               +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Ectasia                              |                               3              2        2     3            |             
      Hyperplasia, Focal                   |                                           4  2                       2   |             
      Hyperplasia, Focal, Squamous         |                                        1                    1  2  1     1|             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  |                               +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Suppurative            |                                                    4                     |             
      Nephropathy, Chronic                 |                               1        1     2  1           2  1  1  1  1|             
      Cortex, Cyst                         |                                                                          |             
      Pelvis, Dilatation                   |                                                    2                     |             
      Renal Tubule, Mineralization         |                                                                          |             
      Renal Tubule, Necrosis, Focal        |                                                                          |             
      Renal Tubule, Pigmentation           |                                                             2            |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  41                                                               
NTP Experiment-Test: 05172-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                               3,3-DIMETHOXYBENZIDINE DIHYDROCHLORIDE                          Date: 04/30/97  
Route: DOSED WATER                                                                                                Time: 17:38:14  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 4| 4| 3| 3| 3| 6| 4| 3| 2| 2| 4| 4| 4| 3| 3|             
                             DAY ON TEST   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 5| 9| 5| 3| 1| 2| 6| 6| 5| 3| 0| 0| 7| 4|             
                                           | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 2| 5| 8| 9| 0| 4| 3| 2| 1| 1| 8| 8| 8| 4|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|             
    330 PPM                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
      Renal Tubule, Vacuolization          |                                                                          |             
          Cytoplasmic                      |                                                                          |             
                                            __________________________________________________________________________|             
   Ureter                                  |                                                    +                     |             
      Dilatation                           |                                                    3                     |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         |                               +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  42                                                               
NTP Experiment-Test: 05172-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                               3,3-DIMETHOXYBENZIDINE DIHYDROCHLORIDE                          Date: 04/30/97  
Route: DOSED WATER                                                                                                Time: 17:38:14  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 4| 3| 3| 3| 6| 5| 4| 4| 2| 5| 4| 4| 3| 3| 5| 4| 4| 3| 2| 4| 4| 4| 4| 3|             
                             DAY ON TEST   | 3| 3| 5| 4| 3| 1| 4| 6| 2| 8| 9| 8| 8| 7| 4| 6| 3| 3| 1| 7| 5| 5| 2| 0| 0|             
                                           | 6| 1| 4| 4| 9| 3| 8| 5| 4| 7| 6| 3| 3| 8| 4| 0| 1| 0| 7| 0| 2| 0| 4| 8| 4|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|             
    330 PPM                                | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage, Focal                    |                                                                          |             
      Submucosa, Inflammation, Acute       |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Parasite Metazoan                    |                                                                          |             
      Muscularis, Mineralization           |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Parasite Metazoan                    |                            1                                             |             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Basophilic Focus                     | 2  3     1  2  2  2  2  3     2  3  2  2  2  1  3     1        2  3  1  1|             
      Clear Cell Focus                     | 2                          1     2              2     2                 1|             
      Cyst                                 |                                     3                                    |             
      Degeneration, Cystic, Focal          |                                                                          |             
      Degeneration, Cystic                 |                1              2                                          |             
      Eosinophilic Focus                   | 2           1     1           2     2     2     1              1        1|             
      Fatty Change                         |                                                                          |             
      Granuloma                            |                                                                          |             
      Hematopoietic Cell Proliferation     | 2  1  1  1  2  2  1     2  1  2  2     1  2     1     1  2        2     1|             
      Hepatodiaphragmatic Nodule           |                                                                          |             
      Necrosis, Coagulative                |                                  3                                       |             
      Necrosis, Focal                      |                      3                    2        2                     |             
      Necrosis, Multifocal                 |                                                                          |             
      Regeneration, Diffuse                |                2                                                         |             
      Regeneration, Multifocal             |                               4              4                           |             
      Thrombosis                           |                                                    X                     |             
      Vacuolization Cytoplasmic, Diffuse   |    2                                                                     |             
      Vacuolization Cytoplasmic, Focal     |                   2                                                      |             
      Bile Duct, Inflammation, Chronic     |                                                       1                  |             
      Centrilobular, Degeneration, Diffuse |       1                                                  2               |             
      Centrilobular, Degeneration          |                                                                2         |             
      Centrilobular, Necrosis, Diffuse     |                               2        3                          3      |             
      Kupffer Cell, Pigmentation           |       3                                                                  |             
                                            __________________________________________________________________________|             
   Mesentery                               |       +                                            +           +         |             
      Fat, Necrosis                        |       2                                            3                     |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage, Focal                    |       4                                                                  |             
                                            __________________________________________________________________________|             
   Pharynx                                 |                +                                                     +   |             
      Mucosa, Palate, Hyperplasia, Focal   |                2                                                         |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  43                                                               
NTP Experiment-Test: 05172-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                               3,3-DIMETHOXYBENZIDINE DIHYDROCHLORIDE                          Date: 04/30/97  
Route: DOSED WATER                                                                                                Time: 17:38:14  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 4| 3| 3| 3| 6| 5| 4| 4| 2| 5| 4| 4| 3| 3| 5| 4| 4| 3| 2| 4| 4| 4| 4| 3|             
                             DAY ON TEST   | 3| 3| 5| 4| 3| 1| 4| 6| 2| 8| 9| 8| 8| 7| 4| 6| 3| 3| 1| 7| 5| 5| 2| 0| 0|             
                                           | 6| 1| 4| 4| 9| 3| 8| 5| 4| 7| 6| 3| 3| 8| 4| 0| 1| 0| 7| 0| 2| 0| 4| 8| 4|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|             
    330 PPM                                | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Acanthosis                           |                                                                2         |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Erosion, Focal                       |                                                                          |             
      Inflammation, Acute                  |                                                                          |             
      Mineralization                       |    2                                                                     |             
                                            __________________________________________________________________________|             
   Tongue                                  |                +                                                         |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cardiomyopathy, Chronic              |    2     1     2        2                 1        2  1           1      |             
      Artery, Mineralization, Multifocal   |                                                                          |             
      Atrium, Thrombosis                   |                                                                          |             
      Epicardium, Inflammation, Chronic    |       2                                                                  |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hematopoietic Cell Proliferation     |                                  2                                       |             
      Hypertrophy, Focal                   |             2                                                            |             
      Infiltration Cellular, Lymphocyte    |                                                                          |             
      Necrosis, Focal                      |                                                    3                     |             
      Vacuolization Cytoplasmic, Diffuse   |    3                                                                     |             
      Vacuolization Cytoplasmic, Focal     |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +|             
      Hematopoietic Cell Proliferation     |                                  2                                       |             
      Hyperplasia, Focal                   |                1                                                         |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                                                          |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Pars Distalis, Angiectasis           |                                                                          |             
      Pars Distalis, Cyst                  | X  X                       X        X  X     X              X  X         |             
      Pars Distalis, Hyperplasia, Focal    |                                                                   3      |             
      Pars Distalis, Necrosis, Focal       |                                                                          |             
      Pars Distalis, Pigmentation, Focal   |                                                                          |             
      Pars Intermedia, Cyst                |                                                       2                  |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      C-Cell, Hyperplasia, Focal           |                                                                   2      |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  44                                                               
NTP Experiment-Test: 05172-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                               3,3-DIMETHOXYBENZIDINE DIHYDROCHLORIDE                          Date: 04/30/97  
Route: DOSED WATER                                                                                                Time: 17:38:14  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 4| 3| 3| 3| 6| 5| 4| 4| 2| 5| 4| 4| 3| 3| 5| 4| 4| 3| 2| 4| 4| 4| 4| 3|             
                             DAY ON TEST   | 3| 3| 5| 4| 3| 1| 4| 6| 2| 8| 9| 8| 8| 7| 4| 6| 3| 3| 1| 7| 5| 5| 2| 0| 0|             
                                           | 6| 1| 4| 4| 9| 3| 8| 5| 4| 7| 6| 3| 3| 8| 4| 0| 1| 0| 7| 0| 2| 0| 4| 8| 4|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|             
    330 PPM                                | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Clitoral Gland                          | +  M  +  +  +  +  M  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |       3                                                                  |             
      Ectasia                              | 3           2           3              2  3                 3        3   |             
      Hyperplasia, Focal                   |                                                                          |             
      Hyperplasia, Focal, Squamous         |                                                                          |             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                                                          |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hydrometra                           |          2                                                               |             
      Endometrium, Cyst                    |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |          2  2  2                                2        2               |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Axillary, Hyperplasia, Lymphoid      |                         2                                                |             
      Mediastinal, Congestion              |                                                       2                  |             
      Mediastinal, Hemorrhage              |          2                                                               |             
      Mediastinal, Hyperplasia, Lymphoid   |                               3        2                                 |             
      Mediastinal, Infiltration Cellular,  |                                                                          |             
           Histiocyte                      |                               3                                          |             
      Pancreatic, Congestion               |                                                                          |             
      Pancreatic, Hyperplasia, Lymphoid    |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +|             
      Hemorrhage                           |                                                                          |             
      Hyperplasia, Lymphoid                |          2                                3                              |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |    4  3                                                                  |             
      Erythrophagocytosis                  |                                                                          |             
      Hyperplasia, Reticulum Cell          |    3  2  2                 1  3        3  2           2  1               |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                                                                          |             
      Hematopoietic Cell Proliferation     | 3  2  2  2  3  3  4  3  4  3  4  4     3  3     3     3  3  2  4  4     3|             
      Pigmentation                         |       3                                                                  |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  M  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Galactocele                          |                                                                          |             
      Duct, Ectasia                        |             1  3                                               2         |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Acanthosis                           |                            2                                             |             
      Inflammation, Chronic                |                            2                                             |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  45                                                               
NTP Experiment-Test: 05172-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                               3,3-DIMETHOXYBENZIDINE DIHYDROCHLORIDE                          Date: 04/30/97  
Route: DOSED WATER                                                                                                Time: 17:38:14  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 4| 3| 3| 3| 6| 5| 4| 4| 2| 5| 4| 4| 3| 3| 5| 4| 4| 3| 2| 4| 4| 4| 4| 3|             
                             DAY ON TEST   | 3| 3| 5| 4| 3| 1| 4| 6| 2| 8| 9| 8| 8| 7| 4| 6| 3| 3| 1| 7| 5| 5| 2| 0| 0|             
                                           | 6| 1| 4| 4| 9| 3| 8| 5| 4| 7| 6| 3| 3| 8| 4| 0| 1| 0| 7| 0| 2| 0| 4| 8| 4|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|             
    330 PPM                                | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM - cont             |                                                                          |             
                                           |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    |    +                             +                                       |             
      Sternum, Osteopetrosis               |    2                             3                                       |             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cerebrum, Necrosis, Focal            |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Congestion                           |                                                    3                     |             
      Foreign Body                         |                                                                          |             
      Hyperplasia, Lymphoid                | 2  2     2  2  3  2  2  2  2  1  2  2  2  2     2  2  1  2     3  3  2  2|             
      Infiltration Cellular, Histiocyte    | 1  2     1  1           2              1        2              2  2  1   |             
      Inflammation, Acute, Multifocal      |                                                                          |             
      Inflammation, Focal, Suppurative     |                                                                          |             
      Parasite Metazoan                    |                                                                          |             
      Alveolar Epithelium, Hyperplasia,    |                                                                          |             
           Focal                           |                                              3                           |             
      Bronchiole, Hyperplasia, Multifocal  |                                                                          |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fungus                               |                                                             3     3      |             
      Hyperkeratosis, Focal                |                                                                          |             
      Inflammation, Chronic                |                                                             2            |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                +                                                         |             
      Inflammation, Chronic                |                2                                                         |             
                                            __________________________________________________________________________|             
   Zymbal's Gland                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Ectasia                              |    2              2                          3                           |             
      Hyperplasia, Focal                   |                                                       1                  |             
      Hyperplasia, Focal, Squamous         |    2                                                                     |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Suppurative            |                                                                          |             
      Nephropathy, Chronic                 |             1  2        1  1  2  1  1  2  1  1     2        2  2         |             
      Cortex, Cyst                         |                                                 4                        |             
      Pelvis, Dilatation                   |                                                                          |             
      Renal Tubule, Mineralization         |    3                                                                     |             
      Renal Tubule, Necrosis, Focal        |                                        2                                 |             
      Renal Tubule, Pigmentation           |    2                                                  2  1     2  2      |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  46                                                               
NTP Experiment-Test: 05172-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                               3,3-DIMETHOXYBENZIDINE DIHYDROCHLORIDE                          Date: 04/30/97  
Route: DOSED WATER                                                                                                Time: 17:38:14  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 4| 3| 3| 3| 6| 5| 4| 4| 2| 5| 4| 4| 3| 3| 5| 4| 4| 3| 2| 4| 4| 4| 4| 3|             
                             DAY ON TEST   | 3| 3| 5| 4| 3| 1| 4| 6| 2| 8| 9| 8| 8| 7| 4| 6| 3| 3| 1| 7| 5| 5| 2| 0| 0|             
                                           | 6| 1| 4| 4| 9| 3| 8| 5| 4| 7| 6| 3| 3| 8| 4| 0| 1| 0| 7| 0| 2| 0| 4| 8| 4|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|             
    330 PPM                                | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
      Renal Tubule, Vacuolization          |                                                                          |             
          Cytoplasmic                      |    3                                                                     |             
                                            __________________________________________________________________________|             
   Ureter                                  |                                                                          |             
      Dilatation                           |                                                                          |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  47                                                               
NTP Experiment-Test: 05172-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                               3,3-DIMETHOXYBENZIDINE DIHYDROCHLORIDE                          Date: 04/30/97  
Route: DOSED WATER                                                                                                Time: 17:38:14  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 4| 4| 3| 2| 5| 4| 4| 3| 3| 6| 5| 5| 4| 4| 6| 5| 4| 4| 4|              |            |
                             DAY ON TEST   | 3| 3| 2| 0| 8| 6| 4| 0| 4| 4| 1| 6| 6| 8| 2| 0| 6| 9| 8| 8|              |            |
                                           | 6| 1| 4| 4| 4| 0| 1| 2| 4| 4| 3| 3| 3| 3| 3| 2| 1| 1| 5| 3|              |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |      O     |
   FISCHER 344 RATS FEMALE                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|              |      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |      A     |
    330 PPM                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|              |      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|              |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  60        |
                                            __________________________________________________________________________|____________|
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  59        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  58        |
      Hemorrhage, Focal                    |                                                                          |      1  4.0|
      Submucosa, Inflammation, Acute       |                2                                                         |      1  2.0|
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  59        |
      Parasite Metazoan                    |                                                                          |      1     |
      Muscularis, Mineralization           |                4                                                         |      1  4.0|
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  59        |
      Parasite Metazoan                    |       X                                                                  |      3  1.0|
                                            __________________________________________________________________________|____________|
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  59        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  58        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  58        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  58        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  60        |
      Basophilic Focus                     | 2  2  3  1  1  2  2     1  1     2  3  3  1  1  3     2  3               |     48  2.0|
      Clear Cell Focus                     | 2                                      1     1  1                        |     15  1.5|
      Cyst                                 |                                                                          |      1  3.0|
      Degeneration, Cystic, Focal          |                                                                          |      2  1.5|
      Degeneration, Cystic                 |                               1                                          |      3  1.3|
      Eosinophilic Focus                   |    2  2  3           3     2     4  2  2     4  2     2  2               |     28  1.9|
      Fatty Change                         |                                        2                                 |      1  2.0|
      Granuloma                            |                                        2  1           2                  |      5  1.6|
      Hematopoietic Cell Proliferation     | 2  1  2  2                 2  1  1  2  2     2  2  2  1  2               |     41  1.5|
      Hepatodiaphragmatic Nodule           |                                                                          |      1     |
      Necrosis, Coagulative                |                      3                                                   |      3  3.3|
      Necrosis, Focal                      |                   1              3                                       |      9  1.9|
      Necrosis, Multifocal                 |                                                 1                        |      1  1.0|
      Regeneration, Diffuse                |                                                                          |      1  2.0|
      Regeneration, Multifocal             |                                                                          |      3  3.7|
      Thrombosis                           |                                                                          |      1     |
      Vacuolization Cytoplasmic, Diffuse   |                                                                          |      1  2.0|
      Vacuolization Cytoplasmic, Focal     |                                     1                                    |      2  1.5|
      Bile Duct, Inflammation, Chronic     |                                                                          |      1  1.0|
      Centrilobular, Degeneration, Diffuse |                                                    3     2               |      4  2.0|
      Centrilobular, Degeneration          |                                                                          |      1  2.0|
      Centrilobular, Necrosis, Diffuse     |          3                 1                                             |      5  2.4|
      Kupffer Cell, Pigmentation           |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Mesentery                               |                      +           +                                       |   7        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  48                                                               
NTP Experiment-Test: 05172-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                               3,3-DIMETHOXYBENZIDINE DIHYDROCHLORIDE                          Date: 04/30/97  
Route: DOSED WATER                                                                                                Time: 17:38:14  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 4| 4| 3| 2| 5| 4| 4| 3| 3| 6| 5| 5| 4| 4| 6| 5| 4| 4| 4|              |            |
                             DAY ON TEST   | 3| 3| 2| 0| 8| 6| 4| 0| 4| 4| 1| 6| 6| 8| 2| 0| 6| 9| 8| 8|              |            |
                                           | 6| 1| 4| 4| 4| 0| 1| 2| 4| 4| 3| 3| 3| 3| 3| 2| 1| 1| 5| 3|              |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |      O     |
   FISCHER 344 RATS FEMALE                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|              |      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |      A     |
    330 PPM                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|              |      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|              |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
                                           |                                                                          |            |
      Fat, Necrosis                        |                      2           3                                       |      5  2.6|
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  59        |
      Hemorrhage, Focal                    |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Pharynx                                 |                                                                          |   2        |
      Mucosa, Palate, Hyperplasia, Focal   |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  59        |
                                            __________________________________________________________________________|____________|
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  59        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  58        |
      Acanthosis                           |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  59        |
      Erosion, Focal                       |                                                                          |      2  2.0|
      Inflammation, Acute                  |                3                                                         |      1  3.0|
      Mineralization                       |                3                                                         |      2  2.5|
                                            __________________________________________________________________________|____________|
   Tongue                                  |                                              +        +                  |   4        |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  60        |
      Cardiomyopathy, Chronic              | 1  2           2                    2  1                                 |     17  1.4|
      Artery, Mineralization, Multifocal   |                2                                                         |      1  2.0|
      Atrium, Thrombosis                   |                               X                                          |      1     |
      Epicardium, Inflammation, Chronic    |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  60        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  60        |
      Hematopoietic Cell Proliferation     |                                                                          |      1  2.0|
      Hypertrophy, Focal                   |                                                                          |      1  2.0|
      Infiltration Cellular, Lymphocyte    |             2                                                            |      1  2.0|
      Necrosis, Focal                      |                                                                          |      1  3.0|
      Vacuolization Cytoplasmic, Diffuse   |                                                    3                     |      3  2.7|
      Vacuolization Cytoplasmic, Focal     |                                                          2               |      1  2.0|
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  59        |
      Hematopoietic Cell Proliferation     |                                                                          |      1  2.0|
      Hyperplasia, Focal                   |                                                 1  1                     |      3  1.0|
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  59        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  59        |
      Hyperplasia                          |                3                                                         |      1  3.0|
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  60        |
      Pars Distalis, Angiectasis           |                   2                                                      |      1  2.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  49                                                               
NTP Experiment-Test: 05172-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                               3,3-DIMETHOXYBENZIDINE DIHYDROCHLORIDE                          Date: 04/30/97  
Route: DOSED WATER                                                                                                Time: 17:38:14  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 4| 4| 3| 2| 5| 4| 4| 3| 3| 6| 5| 5| 4| 4| 6| 5| 4| 4| 4|              |            |
                             DAY ON TEST   | 3| 3| 2| 0| 8| 6| 4| 0| 4| 4| 1| 6| 6| 8| 2| 0| 6| 9| 8| 8|              |            |
                                           | 6| 1| 4| 4| 4| 0| 1| 2| 4| 4| 3| 3| 3| 3| 3| 2| 1| 1| 5| 3|              |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |      O     |
   FISCHER 344 RATS FEMALE                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|              |      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |      A     |
    330 PPM                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|              |      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|              |            |
 __________________________________________________________________________________________________________________________________ 
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
                                           |                                                                          |            |
      Pars Distalis, Cyst                  |          X           X  X  X           X                                 |     19     |
      Pars Distalis, Hyperplasia, Focal    |                                  2                                       |      2  2.5|
      Pars Distalis, Necrosis, Focal       |                4                                                         |      1  4.0|
      Pars Distalis, Pigmentation, Focal   |                   2                                                      |      1  2.0|
      Pars Intermedia, Cyst                |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  59        |
      C-Cell, Hyperplasia, Focal           |    1                                                                     |      3  1.3|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Clitoral Gland                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  55        |
      Atrophy                              |                                                                          |      2  2.5|
      Ectasia                              |                      2  2                          4                     |     12  2.6|
      Hyperplasia, Focal                   |                            2                       2  2  2               |      5  2.0|
      Hyperplasia, Focal, Squamous         |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  58        |
      Cyst                                 | X     X        X  X                                                      |      4     |
                                            __________________________________________________________________________|____________|
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  59        |
      Hydrometra                           |                                                                          |      2  2.0|
      Endometrium, Cyst                    |                         1                                                |      3  1.7|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  60        |
      Hyperplasia                          |    2     2  2              2           2        2     2                  |     14  2.0|
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  60        |
      Axillary, Hyperplasia, Lymphoid      |             2                                   3                        |      3  2.3|
      Mediastinal, Congestion              |                                                                          |      1  2.0|
      Mediastinal, Hemorrhage              |             2                                                            |      2  2.0|
      Mediastinal, Hyperplasia, Lymphoid   |                                                                          |      4  2.5|
      Mediastinal, Infiltration Cellular,  |                                                                          |            |
           Histiocyte                      |                                                                          |      1  3.0|
      Pancreatic, Congestion               |                               3                                          |      1  3.0|
      Pancreatic, Hyperplasia, Lymphoid    |                               3                                          |      2  3.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  59        |
      Hemorrhage                           |                   3                                                      |      1  3.0|
      Hyperplasia, Lymphoid                |                                                       3                  |      4  2.5|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  58        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  50                                                               
NTP Experiment-Test: 05172-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                               3,3-DIMETHOXYBENZIDINE DIHYDROCHLORIDE                          Date: 04/30/97  
Route: DOSED WATER                                                                                                Time: 17:38:14  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 4| 4| 3| 2| 5| 4| 4| 3| 3| 6| 5| 5| 4| 4| 6| 5| 4| 4| 4|              |            |
                             DAY ON TEST   | 3| 3| 2| 0| 8| 6| 4| 0| 4| 4| 1| 6| 6| 8| 2| 0| 6| 9| 8| 8|              |            |
                                           | 6| 1| 4| 4| 4| 0| 1| 2| 4| 4| 3| 3| 3| 3| 3| 2| 1| 1| 5| 3|              |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |      O     |
   FISCHER 344 RATS FEMALE                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|              |      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |      A     |
    330 PPM                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|              |      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|              |            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
      Atrophy                              |                                                                          |      2  3.5|
      Erythrophagocytosis                  |                                                                          |      1  3.0|
      Hyperplasia, Reticulum Cell          |    2                 2  3  2              2                              |     18  2.2|
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  60        |
      Atrophy                              |                                                                          |      2  3.0|
      Hematopoietic Cell Proliferation     | 4  2  4  4  2     3        3     3  4  3     3  4  4  2  3               |     47  3.1|
      Pigmentation                         |                3                                                         |      2  3.0|
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +  M  +  +  M  +  +  +  +  +  +  +  M  +  +  +  +  +  M               |  54        |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  59        |
      Galactocele                          |                                  X                                       |      1     |
      Duct, Ectasia                        |                                  3                                       |      5  2.2|
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  60        |
      Acanthosis                           |                                                                          |      1  2.0|
      Inflammation, Chronic                |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    |                               +     +                                    |   4        |
      Sternum, Osteopetrosis               |                               4     3                                    |      4  3.0|
                                            __________________________________________________________________________|____________|
   Skeletal Muscle                         |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  60        |
      Cerebrum, Necrosis, Focal            |                4                                                         |      1  4.0|
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  60        |
      Congestion                           |                                                                          |      1  3.0|
      Foreign Body                         |                                                                          |      1  2.0|
      Hyperplasia, Lymphoid                | 2  2  2  2  2  2  1  1  2  2     2  2     1  2  2  2  2  2               |     53  2.0|
      Infiltration Cellular, Histiocyte    | 2  1  1           1              2                                       |     18  1.5|
      Inflammation, Acute, Multifocal      |                                                                          |      1  4.0|
      Inflammation, Focal, Suppurative     |                                        4                                 |      1  4.0|
      Parasite Metazoan                    |                                        X                                 |      1     |
      Alveolar Epithelium, Hyperplasia,    |                                                                          |            |
           Focal                           |                               2                                          |      2  2.5|
      Bronchiole, Hyperplasia, Multifocal  |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  60        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  51                                                               
NTP Experiment-Test: 05172-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                               3,3-DIMETHOXYBENZIDINE DIHYDROCHLORIDE                          Date: 04/30/97  
Route: DOSED WATER                                                                                                Time: 17:38:14  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 4| 4| 3| 2| 5| 4| 4| 3| 3| 6| 5| 5| 4| 4| 6| 5| 4| 4| 4|              |            |
                             DAY ON TEST   | 3| 3| 2| 0| 8| 6| 4| 0| 4| 4| 1| 6| 6| 8| 2| 0| 6| 9| 8| 8|              |            |
                                           | 6| 1| 4| 4| 4| 0| 1| 2| 4| 4| 3| 3| 3| 3| 3| 2| 1| 1| 5| 3|              |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |      O     |
   FISCHER 344 RATS FEMALE                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|              |      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |      A     |
    330 PPM                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|              |      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|              |            |
 __________________________________________________________________________________________________________________________________ 
 RESPIRATORY SYSTEM - cont                 |                                                                          |            |
                                           |                                                                          |            |
      Fungus                               |                                                                          |      2  3.0|
      Hyperkeratosis, Focal                |                2                                                         |      1  2.0|
      Inflammation, Chronic                |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  60        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Harderian Gland                         |                                                                          |   1        |
      Inflammation, Chronic                |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Zymbal's Gland                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  60        |
      Ectasia                              | 3  2                          2  3           3  2  3     4               |     15  2.6|
      Hyperplasia, Focal                   |                               2                                          |      5  2.2|
      Hyperplasia, Focal, Squamous         |                                  2                       3               |      8  1.6|
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  60        |
      Inflammation, Suppurative            |                                                                          |      1  4.0|
      Nephropathy, Chronic                 | 1  3     2  2  3  1  1  1  2  2     1     1     1  3  1                  |     37  1.5|
      Cortex, Cyst                         |          3                                                               |      2  3.5|
      Pelvis, Dilatation                   |                                                                          |      1  2.0|
      Renal Tubule, Mineralization         |                3                                                         |      2  3.0|
      Renal Tubule, Necrosis, Focal        |                                                                          |      1  2.0|
      Renal Tubule, Pigmentation           |                   2                                                      |      7  1.9|
      Renal Tubule, Vacuolization          |                                                                          |            |
          Cytoplasmic                      |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Ureter                                  |                                                                          |   1        |
      Dilatation                           |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  59        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  52                                                               
NTP Experiment-Test: 05172-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                               3,3-DIMETHOXYBENZIDINE DIHYDROCHLORIDE                          Date: 04/30/97  
Route: DOSED WATER                                                                                                Time: 17:38:14  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 6| 6| 5| 5| 4| 6| 6| 6| 5| 5| 6| 6| 6| 6| 6|             
                             DAY ON TEST   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 4| 4| 3| 2| 5| 4| 4| 4| 8| 0| 4| 4| 4| 4| 4|             
                                           | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 7| 7| 1| 9| 2| 7| 5| 7| 1| 5| 7| 7| 7| 7| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    CONTROL                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               |                               +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large                         |                               +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  |                               +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  |                               +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 |                               +  +  +     +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small                         |                               +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               |                               +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  |                               +  +  +     +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                |                               +  +  +     +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Liver                                   |                               +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Basophilic Focus                     |                               1  1     1     1     1  2     2  1     1   |             
      Clear Cell Focus                     |                               1              1              1  1     1   |             
      Degeneration, Cystic, Focal          |                                              1                           |             
      Degeneration, Cystic                 |                                                                   1      |             
      Eosinophilic Focus                   |                                              2     1              1      |             
      Fatty Change                         |                                                                          |             
      Granuloma                            |                                                                          |             
      Hematopoietic Cell Proliferation     |                                           1                    1         |             
      Hepatodiaphragmatic Nodule           |                                           X           X     X            |             
      Infarct, Chronic                     |                                                                          |             
      Regeneration, Focal                  |                                                 4                        |             
      Regeneration, Multifocal             |                                                                          |             
      Vacuolization Cytoplasmic, Multifocal|                                                                          |             
      Bile Duct, Hyperplasia               |                                  2           2     2  2                  |             
      Centrilobular, Necrosis, Diffuse     |                                     4                                    |             
      Centrilobular, Necrosis              |                                                          2               |             
      Serosa, Hemorrhage                   |                               2                                          |             
                                            __________________________________________________________________________|             
   Mesentery                               |                                     +  +     +              +        +   |             
      Artery, Inflammation, Chronic        |                                                                          |             
      Fat, Necrosis                        |                                     3        3              3            |             
                                            __________________________________________________________________________|             
   Pancreas                                |                               +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                                                    2  2                  |             
                                            __________________________________________________________________________|             
   Pharynx                                 |                                                                          |             
      Palate, Necrosis                     |                                                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         |                               +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach                                 |                               +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    |                               +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Acanthosis                           |                                                       2                  |             
      Ulcer                                |                                                          3               |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      |                               +  +  +     +  +  +  +  +  +  +  +  +  +  +|             
      Erosion, Focal                       |                                                                          |             
      Submucosa, Hemorrhage, Focal         |                                                                          |             
                                            __________________________________________________________________________|             
   Tongue                                  |                               +                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  53                                                               
NTP Experiment-Test: 05172-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                               3,3-DIMETHOXYBENZIDINE DIHYDROCHLORIDE                          Date: 04/30/97  
Route: DOSED WATER                                                                                                Time: 17:38:14  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 6| 6| 5| 5| 4| 6| 6| 6| 5| 5| 6| 6| 6| 6| 6|             
                             DAY ON TEST   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 4| 4| 3| 2| 5| 4| 4| 4| 8| 0| 4| 4| 4| 4| 4|             
                                           | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 7| 7| 1| 9| 2| 7| 5| 7| 1| 5| 7| 7| 7| 7| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    CONTROL                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |             
                                           |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   |                               +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cardiomyopathy, Chronic              |                               2  2  3  2  1  2  2  3  2  2  2     1     2|             
      Mineralization, Multifocal           |                                                                          |             
      Atrium, Thrombosis                   |                                  X                                       |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           |                               +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   |                               +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Focal                   |                                                                2         |             
      Vacuolization Cytoplasmic, Focal     |                                                                          |             
      Vacuolization Cytoplasmic, Multifocal|                                                                      2   |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  |                               +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Focal                   |                                                                2  2      |             
      Hyperplasia                          |                                                                          |             
      Hyperplasia, Multifocal              |                                  2                                       |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      |                               +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       |                               +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         |                               +  +  +  +  M  +  +  +  +  +  +  +  +  +  +|             
      Pigmentation                         |                               3                                          |             
      Pars Distalis, Ectasia, Focal        |                                                                          |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           |                               +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      C-Cell, Hyperplasia, Focal           |                                                                          |             
      C-Cell, Hyperplasia, Multifocal      |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              |                               +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Preputial Gland                         |                               +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                                                       3                  |             
      Ectasia                              |                               3                             3            |             
      Hyperplasia, Focal                   |                                                             2            |             
      Hyperplasia, Squamous                |                                                                          |             
                                            __________________________________________________________________________|             
   Prostate                                |                               +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Focal, Glandular        |                                              1                           |             
      Hyperplasia, Glandular, Multifocal   |                                                                          |             
      Inflammation, Chronic Active         |                                           2           2                  |             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         |                               +  +  +  +  M  +  +  +  +  +  +  +  +  +  +|             
      Bilateral, Atrophy                   |                                        3                                 |             
                                            __________________________________________________________________________|             
   Testes                                  |                               +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                                        4                                4|             
      Interstitial Cell, Hyperplasia       |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  54                                                               
NTP Experiment-Test: 05172-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                               3,3-DIMETHOXYBENZIDINE DIHYDROCHLORIDE                          Date: 04/30/97  
Route: DOSED WATER                                                                                                Time: 17:38:14  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 6| 6| 5| 5| 4| 6| 6| 6| 5| 5| 6| 6| 6| 6| 6|             
                             DAY ON TEST   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 4| 4| 3| 2| 5| 4| 4| 4| 8| 0| 4| 4| 4| 4| 4|             
                                           | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 7| 7| 1| 9| 2| 7| 5| 7| 1| 5| 7| 7| 7| 7| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    CONTROL                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             |                               +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node                              |                               +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  |                               +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Lymphoid                |                                                                         3|             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  |                               +  +  +  +  +  +  +  +  +  +  +  +  +  +  A|             
      Ectasia                              |                                                                          |             
      Hyperplasia, Lymphoid                |                                                                          |             
                                            __________________________________________________________________________|             
   Spleen                                  |                               +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                                                                         3|             
      Hematopoietic Cell Proliferation     |                                           3                              |             
      Hyperplasia, Reticulum Cell          |                                                                          |             
                                            __________________________________________________________________________|             
   Thymus                                  |                               +  +  +  M  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                                                                          |             
      Epithelial Cell, Hyperplasia, Focal  |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           |                               +  +  +  M  +  +  +  +  +  M  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Skin                                    |                               +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Abscess                              |                                                             3            |             
      Acanthosis, Multifocal               |                                                                          |             
      Cyst Epithelial Inclusion            |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   |                               +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    |                               +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Foreign Body                         |                                                                         3|             
      Hyperplasia, Lymphoid                |                               2  2  1  2  2  2     2  2     2  1  1  2   |             
      Inflammation, Suppurative            |                                                                         4|             
      Alveolar Epithelium, Hyperplasia,    |                                                                          |             
           Focal                           |                                                                          |             
                                            __________________________________________________________________________|             
   Nose                                    |                               +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Foreign Body                         |                                                                         4|             
      Fungus                               |                                                                      2   |             
      Hyperkeratosis                       |                                                                          |             
      Inflammation, Acute                  |                                                                      2  4|             
                                            __________________________________________________________________________|             
   Trachea                                 |                               +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  55                                                               
NTP Experiment-Test: 05172-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                               3,3-DIMETHOXYBENZIDINE DIHYDROCHLORIDE                          Date: 04/30/97  
Route: DOSED WATER                                                                                                Time: 17:38:14  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 6| 6| 5| 5| 4| 6| 6| 6| 5| 5| 6| 6| 6| 6| 6|             
                             DAY ON TEST   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 4| 4| 3| 2| 5| 4| 4| 4| 8| 0| 4| 4| 4| 4| 4|             
                                           | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 7| 7| 1| 9| 2| 7| 5| 7| 1| 5| 7| 7| 7| 7| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    CONTROL                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                                                                          |             
      Cataract                             |                                                                          |             
      Degeneration                         |                                                                          |             
      Retina, Degeneration                 |                                                                          |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                                                                   +      |             
                                            __________________________________________________________________________|             
   Zymbal's Gland                          |                               +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Ectasia                              |                               1     2  1  2  2  2     1     2  2  2  1  2|             
      Hyperplasia, Multifocal              |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  |                               +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Nephropathy, Chronic                 |                               3  3        3  3  2  3  2     2  3  2  2   |             
      Proximal Convoluted Renal Tubule,    |                                                                          |             
           Necrosis, Diffuse               |                                                                          |             
      Renal Tubule, Pigmentation           |                                        4                                 |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         |                               +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Edema                                |                                     3                                    |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  56                                                               
NTP Experiment-Test: 05172-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                               3,3-DIMETHOXYBENZIDINE DIHYDROCHLORIDE                          Date: 04/30/97  
Route: DOSED WATER                                                                                                Time: 17:38:14  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 6| 6| 6| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 0| 6| 6| 6| 6| 6|             
                             DAY ON TEST   | 4| 4| 4| 4| 7| 4| 4| 4| 4| 4| 4| 4| 4| 4| 2| 4| 4| 4| 0| 7| 4| 4| 4| 4| 4|             
                                           | 7| 7| 7| 7| 3| 7| 7| 7| 7| 7| 7| 6| 7| 7| 9| 7| 7| 7| 3| 3| 7| 7| 7| 7| 7|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|             
    CONTROL                                | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Basophilic Focus                     |    2     1     1  1  1  1  1  1     1  2  1  1  1     2     1     1  1  1|             
      Clear Cell Focus                     | 1  1                          1              1  1           1            |             
      Degeneration, Cystic, Focal          |    1                                               1           2         |             
      Degeneration, Cystic                 |                         1           1        1  1                        |             
      Eosinophilic Focus                   |                                                             1            |             
      Fatty Change                         |                                                          2               |             
      Granuloma                            |                                              2                           |             
      Hematopoietic Cell Proliferation     |                                                                          |             
      Hepatodiaphragmatic Nodule           |                            X                                             |             
      Infarct, Chronic                     |                                     3                                    |             
      Regeneration, Focal                  |       2                                                                  |             
      Regeneration, Multifocal             |                                                                          |             
      Vacuolization Cytoplasmic, Multifocal|                                                 2           2            |             
      Bile Duct, Hyperplasia               | 2  2                 2                 2     2        2                  |             
      Centrilobular, Necrosis, Diffuse     |                                           4                              |             
      Centrilobular, Necrosis              |                                  2                                       |             
      Serosa, Hemorrhage                   |                                                                          |             
                                            __________________________________________________________________________|             
   Mesentery                               |    +     +  +           +        +        +                 +  +  +     +|             
      Artery, Inflammation, Chronic        |                                                             3            |             
      Fat, Necrosis                        |    3     3  3           3        3                                3     3|             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                                                 3  2  2     2        2   |             
                                            __________________________________________________________________________|             
   Pharynx                                 |                      +                                                   |             
      Palate, Necrosis                     |                      3                                                   |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Acanthosis                           |                                                                         2|             
      Ulcer                                |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Erosion, Focal                       |                                                          2               |             
      Submucosa, Hemorrhage, Focal         |                                                                          |             
                                            __________________________________________________________________________|             
   Tongue                                  |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  57                                                               
NTP Experiment-Test: 05172-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                               3,3-DIMETHOXYBENZIDINE DIHYDROCHLORIDE                          Date: 04/30/97  
Route: DOSED WATER                                                                                                Time: 17:38:14  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 6| 6| 6| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 0| 6| 6| 6| 6| 6|             
                             DAY ON TEST   | 4| 4| 4| 4| 7| 4| 4| 4| 4| 4| 4| 4| 4| 4| 2| 4| 4| 4| 0| 7| 4| 4| 4| 4| 4|             
                                           | 7| 7| 7| 7| 3| 7| 7| 7| 7| 7| 7| 6| 7| 7| 9| 7| 7| 7| 3| 3| 7| 7| 7| 7| 7|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|             
    CONTROL                                | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |             
                                           |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cardiomyopathy, Chronic              |    2  2  2  2  1  2     2  2  2  2     3  2  2  2           2  2     2   |             
      Mineralization, Multifocal           |                                                          4               |             
      Atrium, Thrombosis                   |             X                                                            |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Focal                   |                                                                         2|             
      Vacuolization Cytoplasmic, Focal     |                      2                                                   |             
      Vacuolization Cytoplasmic, Multifocal|                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Focal                   |                                                                          |             
      Hyperplasia                          |                                              2                           |             
      Hyperplasia, Multifocal              |                                                                          |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Pigmentation                         |                                                                          |             
      Pars Distalis, Ectasia, Focal        |                                     2                                    |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      C-Cell, Hyperplasia, Focal           |                1     1                                                   |             
      C-Cell, Hyperplasia, Multifocal      |       2                                                                  |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Preputial Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |             3                                                            |             
      Ectasia                              |          3                                   3  3                        |             
      Hyperplasia, Focal                   |                                                                          |             
      Hyperplasia, Squamous                |                                              2                           |             
                                            __________________________________________________________________________|             
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Focal, Glandular        |    1           1                                               1         |             
      Hyperplasia, Glandular, Multifocal   |                               2                                          |             
      Inflammation, Chronic Active         |                                                 3                        |             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +|             
      Bilateral, Atrophy                   |                                                                          |             
                                            __________________________________________________________________________|             
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                                                                          |             
      Interstitial Cell, Hyperplasia       |                      3                                                   |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  58                                                               
NTP Experiment-Test: 05172-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                               3,3-DIMETHOXYBENZIDINE DIHYDROCHLORIDE                          Date: 04/30/97  
Route: DOSED WATER                                                                                                Time: 17:38:14  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 6| 6| 6| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 0| 6| 6| 6| 6| 6|             
                             DAY ON TEST   | 4| 4| 4| 4| 7| 4| 4| 4| 4| 4| 4| 4| 4| 4| 2| 4| 4| 4| 0| 7| 4| 4| 4| 4| 4|             
                                           | 7| 7| 7| 7| 3| 7| 7| 7| 7| 7| 7| 6| 7| 7| 9| 7| 7| 7| 3| 3| 7| 7| 7| 7| 7|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|             
    CONTROL                                | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                                       3                  |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Lymphoid                |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Ectasia                              |                                                                          |             
      Hyperplasia, Lymphoid                |                                                                          |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                                                          3              2|             
      Hematopoietic Cell Proliferation     |                                                       2                  |             
      Hyperplasia, Reticulum Cell          |                                                    3                     |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  M  M|             
      Atrophy                              |                                                          4               |             
      Epithelial Cell, Hyperplasia, Focal  |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Abscess                              |                                                                          |             
      Acanthosis, Multifocal               |                                                                          |             
      Cyst Epithelial Inclusion            |                                     X                       X            |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Foreign Body                         |                                                          3               |             
      Hyperplasia, Lymphoid                | 2  1  3  2  2  2     2     2  2     2  2  2  1  2     2     2     2  3  2|             
      Inflammation, Suppurative            |                                                                          |             
      Alveolar Epithelium, Hyperplasia,    |                                                                          |             
           Focal                           |                                                                          |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Foreign Body                         |                                                                          |             
      Fungus                               |                                                                         3|             
      Hyperkeratosis                       |                                                                         3|             
      Inflammation, Acute                  |             2                                                           3|             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  59                                                               
NTP Experiment-Test: 05172-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                               3,3-DIMETHOXYBENZIDINE DIHYDROCHLORIDE                          Date: 04/30/97  
Route: DOSED WATER                                                                                                Time: 17:38:14  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 6| 6| 6| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 0| 6| 6| 6| 6| 6|             
                             DAY ON TEST   | 4| 4| 4| 4| 7| 4| 4| 4| 4| 4| 4| 4| 4| 4| 2| 4| 4| 4| 0| 7| 4| 4| 4| 4| 4|             
                                           | 7| 7| 7| 7| 3| 7| 7| 7| 7| 7| 7| 6| 7| 7| 9| 7| 7| 7| 3| 3| 7| 7| 7| 7| 7|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|             
    CONTROL                                | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |          +        +                                            +         |             
      Cataract                             |          3                                                               |             
      Degeneration                         |                                                                          |             
      Retina, Degeneration                 |          4        4                                            3         |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                                                                          |             
                                            __________________________________________________________________________|             
   Zymbal's Gland                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Ectasia                              | 1  1  1  2  2     1  1  2     2  2  2  1  1        1  1     1     1  1  2|             
      Hyperplasia, Multifocal              |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Nephropathy, Chronic                 | 2  2  2  2  2  2  3  2  3  3  3     3  3     3  3  3  2     3  3  2  3  3|             
      Proximal Convoluted Renal Tubule,    |                                                                          |             
           Necrosis, Diffuse               |                                                          3               |             
      Renal Tubule, Pigmentation           |                                                                          |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Edema                                |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  60                                                               
NTP Experiment-Test: 05172-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                               3,3-DIMETHOXYBENZIDINE DIHYDROCHLORIDE                          Date: 04/30/97  
Route: DOSED WATER                                                                                                Time: 17:38:14  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|              |            |
                             DAY ON TEST   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 1| 0| 4| 4| 4| 4| 4|              |            |
                                           | 7| 7| 7| 4| 5| 7| 7| 7| 7| 7| 7| 7| 7| 6| 3| 7| 7| 7| 7| 7|              |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|              |      A     |
    CONTROL                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|              |      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|              |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  60        |
                                            __________________________________________________________________________|____________|
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  60        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  60        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  60        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  59        |
                                            __________________________________________________________________________|____________|
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  60        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  60        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  59        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  59        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  60        |
      Basophilic Focus                     |    1     2     2  1  2  1  1  1  1  1  1  1  1        1  1               |     42  1.2|
      Clear Cell Focus                     |                1     1  1     2  1  1           1        1               |     19  1.1|
      Degeneration, Cystic, Focal          |       2  1                                                               |      6  1.3|
      Degeneration, Cystic                 |                2                    2                                    |      7  1.3|
      Eosinophilic Focus                   |                      1              1                                    |      6  1.2|
      Fatty Change                         |                                        2                                 |      2  2.0|
      Granuloma                            |                               3                                          |      2  2.5|
      Hematopoietic Cell Proliferation     |                                                                          |      2  1.0|
      Hepatodiaphragmatic Nodule           |                                                                          |      4     |
      Infarct, Chronic                     |                                                                          |      1  3.0|
      Regeneration, Focal                  |                3                    3                                    |      4  3.0|
      Regeneration, Multifocal             |          3                                                               |      1  3.0|
      Vacuolization Cytoplasmic, Multifocal|                                                                          |      2  2.0|
      Bile Duct, Hyperplasia               |                      2     2           2              3                  |     14  2.1|
      Centrilobular, Necrosis, Diffuse     |                                                                          |      2  4.0|
      Centrilobular, Necrosis              |                                                                          |      2  2.0|
      Serosa, Hemorrhage                   |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Mesentery                               |                +     +     +     +  +     +  +                           |  22        |
      Artery, Inflammation, Chronic        |                                                                          |      1  3.0|
      Fat, Necrosis                        |                3     3     3     3  3     3  3                           |     17  3.0|
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  60        |
      Atrophy                              |                2                                   2                     |      9  2.1|
                                            __________________________________________________________________________|____________|
   Pharynx                                 |                                                                          |   1        |
      Palate, Necrosis                     |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  60        |
                                            __________________________________________________________________________|____________|
   Stomach                                 | +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +               |  59        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +               |  59        |
      Acanthosis                           |                                                                          |      2  2.0|
      Ulcer                                |                                                                          |      1  3.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  61                                                               
NTP Experiment-Test: 05172-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                               3,3-DIMETHOXYBENZIDINE DIHYDROCHLORIDE                          Date: 04/30/97  
Route: DOSED WATER                                                                                                Time: 17:38:14  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|              |            |
                             DAY ON TEST   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 1| 0| 4| 4| 4| 4| 4|              |            |
                                           | 7| 7| 7| 4| 5| 7| 7| 7| 7| 7| 7| 7| 7| 6| 3| 7| 7| 7| 7| 7|              |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|              |      A     |
    CONTROL                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|              |      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|              |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +               |  58        |
      Erosion, Focal                       |                                                                          |      1  2.0|
      Submucosa, Hemorrhage, Focal         |          3                                                               |      1  3.0|
                                            __________________________________________________________________________|____________|
   Tongue                                  |                                        +                                 |   2        |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  60        |
      Cardiomyopathy, Chronic              | 2  2     2  2  1     2  2     1  2  1  2  2  2  2  2  2  3               |     47  2.0|
      Mineralization, Multifocal           |                                                                          |      1  4.0|
      Atrium, Thrombosis                   |                                           X                              |      3     |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  60        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  60        |
      Hyperplasia, Focal                   |                                                 1                        |      3  1.7|
      Vacuolization Cytoplasmic, Focal     |                                                                          |      1  2.0|
      Vacuolization Cytoplasmic, Multifocal|                               2                                          |      2  2.0|
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  60        |
      Hyperplasia, Focal                   |    2                             3                                       |      4  2.3|
      Hyperplasia                          |       3                                                                  |      2  2.5|
      Hyperplasia, Multifocal              |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  60        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  60        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +               |  58        |
      Pigmentation                         |                                                                          |      1  3.0|
      Pars Distalis, Ectasia, Focal        |                                                          3               |      2  2.5|
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  60        |
      C-Cell, Hyperplasia, Focal           | 1  2                                3           1                        |      6  1.5|
      C-Cell, Hyperplasia, Multifocal      |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  60        |
                                            __________________________________________________________________________|____________|
   Preputial Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  60        |
      Atrophy                              |             3  3                                                         |      4  3.0|
      Ectasia                              |                                                                          |      5  3.0|
      Hyperplasia, Focal                   |                                                                          |      1  2.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  62                                                               
NTP Experiment-Test: 05172-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                               3,3-DIMETHOXYBENZIDINE DIHYDROCHLORIDE                          Date: 04/30/97  
Route: DOSED WATER                                                                                                Time: 17:38:14  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|              |            |
                             DAY ON TEST   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 1| 0| 4| 4| 4| 4| 4|              |            |
                                           | 7| 7| 7| 4| 5| 7| 7| 7| 7| 7| 7| 7| 7| 6| 3| 7| 7| 7| 7| 7|              |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|              |      A     |
    CONTROL                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|              |      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|              |            |
 __________________________________________________________________________________________________________________________________ 
 GENITAL SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
      Hyperplasia, Squamous                |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  60        |
      Hyperplasia, Focal, Glandular        |             2                                                            |      5  1.2|
      Hyperplasia, Glandular, Multifocal   | 1                       2        3                       2               |      5  2.0|
      Inflammation, Chronic Active         |                                                       2  2               |      5  2.2|
                                            __________________________________________________________________________|____________|
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  58        |
      Bilateral, Atrophy                   |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  60        |
      Atrophy                              |                                                    3                     |      3  3.7|
      Interstitial Cell, Hyperplasia       |                   2                                                      |      2  2.5|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  60        |
      Hyperplasia                          |                                           2                              |      2  2.5|
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  60        |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  60        |
      Hyperplasia, Lymphoid                |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  59        |
      Ectasia                              |                            3                                             |      1  3.0|
      Hyperplasia, Lymphoid                |                                                 3                        |      1  3.0|
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  60        |
      Atrophy                              |                                                                          |      3  2.7|
      Hematopoietic Cell Proliferation     |                                           2                              |      3  2.3|
      Hyperplasia, Reticulum Cell          |                                     4                                    |      2  3.5|
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  M  +  +  M  +  +  +  +  +  +               |  53        |
      Atrophy                              |                                                                          |      1  4.0|
      Epithelial Cell, Hyperplasia, Focal  |                                  3                                       |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  +  M  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +               |  56        |
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  60        |
      Abscess                              |                                                                          |      1  3.0|
      Acanthosis, Multifocal               |                3                                                         |      1  3.0|
      Cyst Epithelial Inclusion            |                                                                          |      2     |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  63                                                               
NTP Experiment-Test: 05172-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                               3,3-DIMETHOXYBENZIDINE DIHYDROCHLORIDE                          Date: 04/30/97  
Route: DOSED WATER                                                                                                Time: 17:38:14  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|              |            |
                             DAY ON TEST   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 1| 0| 4| 4| 4| 4| 4|              |            |
                                           | 7| 7| 7| 4| 5| 7| 7| 7| 7| 7| 7| 7| 7| 6| 3| 7| 7| 7| 7| 7|              |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|              |      A     |
    CONTROL                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|              |      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|              |            |
 __________________________________________________________________________________________________________________________________ 
 NERVOUS SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  60        |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  60        |
      Foreign Body                         |                                                                          |      2  3.0|
      Hyperplasia, Lymphoid                | 2  2     2     2  2  2  2  2  2  2  2  2  2  2  2  2  2  2               |     49  1.9|
      Inflammation, Suppurative            |                                                                          |      1  4.0|
      Alveolar Epithelium, Hyperplasia,    |                                                                          |            |
           Focal                           |                         2                                                |      1  2.0|
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  60        |
      Foreign Body                         |                                                                          |      1  4.0|
      Fungus                               |                      2                                2                  |      4  2.3|
      Hyperkeratosis                       |                   2                                                      |      2  2.5|
      Inflammation, Acute                  |                                        2              2                  |      6  2.5|
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  60        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Eye                                     | +                                                                        |   4        |
      Cataract                             |                                                                          |      1  3.0|
      Degeneration                         | 4                                                                        |      1  4.0|
      Retina, Degeneration                 |                                                                          |      3  3.7|
                                            __________________________________________________________________________|____________|
   Harderian Gland                         |                                                                          |   1        |
                                            __________________________________________________________________________|____________|
   Zymbal's Gland                          | +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  59        |
      Ectasia                              |    2  2     2     2  2        3        3  2     2     2  1               |     42  1.6|
      Hyperplasia, Multifocal              |                               3                                          |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  60        |
      Nephropathy, Chronic                 | 3  2  2  3  1  2  3  2  2  2  3  2  3  2  2  3  2  3  2  2               |     53  2.5|
      Proximal Convoluted Renal Tubule,    |                                                                          |            |
           Necrosis, Diffuse               |                                                                          |      1  3.0|
      Renal Tubule, Pigmentation           |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  60        |
      Edema                                |                                                                          |      1  3.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  64                                                               
NTP Experiment-Test: 05172-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                               3,3-DIMETHOXYBENZIDINE DIHYDROCHLORIDE                          Date: 04/30/97  
Route: DOSED WATER                                                                                                Time: 17:38:14  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 5| 5| 4| 3| 6| 6| 6| 6| 4| 6| 6| 6| 5| 2| 6| 6| 6| 5| 5| 6| 5| 5| 4| 4|             
                             DAY ON TEST   | 4| 9| 5| 8| 5| 4| 4| 1| 1| 8| 1| 0| 0| 4| 6| 4| 1| 0| 9| 7| 1| 3| 1| 8| 8|             
                                           | 4| 6| 2| 0| 3| 4| 7| 8| 8| 3| 0| 3| 3| 6| 2| 1| 1| 2| 6| 8| 8| 8| 5| 5| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    80 PPM                                 | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperkeratosis                       |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +|             
      Mucosa, Necrosis, Focal              |                                                                          |             
      Submucosa, Edema                     |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +|             
      Parasite Metazoan                    |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  M  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Basophilic Focus                     | 1  2  2  1     2  1  2     1     1  2  2        1  1  1     2     1     1|             
      Clear Cell Focus                     |    1                       1        1                                1   |             
      Degeneration, Cystic, Focal          |                                                                          |             
      Degeneration, Cystic                 | 2  3  2        1     1  2     2              2  2              2  2      |             
      Degeneration, Cystic, Multifocal     |                                                                          |             
      Ectasia, Multifocal                  |                                                                          |             
      Eosinophilic Focus                   |                2  2  1  1        2  1           1           2            |             
      Granuloma                            |                         3                                               2|             
      Hematopoietic Cell Proliferation     |                2  1  1     1  1     2     1     1           2            |             
      Hepatodiaphragmatic Nodule           |       X        X                                                         |             
      Hepatodiaphragmatic Nodule, Multiple |                                                                          |             
      Infarct, Chronic                     | 4              3                                                         |             
      Necrosis, Coagulative                |                                                                      2   |             
      Necrosis, Focal                      |          1                                                               |             
      Regeneration, Diffuse                |                                                                          |             
      Regeneration, Focal                  |                                                                          |             
      Regeneration, Multifocal             |       2                                                                  |             
      Thrombosis                           |                                              X  X                        |             
      Vacuolization Cytoplasmic, Multifocal|                                     1                                    |             
      Bile Duct, Hyperplasia               |                2                                                         |             
      Centrilobular, Degeneration, Diffuse |                1                                                         |             
      Centrilobular, Necrosis, Diffuse     |             4                 4                 3              4         |             
      Centrilobular, Necrosis, Focal       |                                                                          |             
      Centrilobular, Necrosis              |       2                                               2                  |             
      Centrilobular, Necrosis, Multifocal  |                                                                          |             
                                            __________________________________________________________________________|             
   Mesentery                               | +                                                  +           +     +   |             
      Artery, Mineralization               |                                                                          |             
      Fat, Necrosis                        | 3                                                  3           3     3   |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                                                                2        2|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  65                                                               
NTP Experiment-Test: 05172-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                               3,3-DIMETHOXYBENZIDINE DIHYDROCHLORIDE                          Date: 04/30/97  
Route: DOSED WATER                                                                                                Time: 17:38:14  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 5| 5| 4| 3| 6| 6| 6| 6| 4| 6| 6| 6| 5| 2| 6| 6| 6| 5| 5| 6| 5| 5| 4| 4|             
                             DAY ON TEST   | 4| 9| 5| 8| 5| 4| 4| 1| 1| 8| 1| 0| 0| 4| 6| 4| 1| 0| 9| 7| 1| 3| 1| 8| 8|             
                                           | 4| 6| 2| 0| 3| 4| 7| 8| 8| 3| 0| 3| 3| 6| 2| 1| 1| 2| 6| 8| 8| 8| 5| 5| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    80 PPM                                 | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
                                           |                                                                          |             
      Acinus, Hypertrophy, Multifocal      |                                                                          |             
                                            __________________________________________________________________________|             
   Pharynx                                 |                +                                                         |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                                                                          |             
      Interlobular, Edema                  |                                                                          |             
      Parotid Gland, Atrophy               |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +|             
      Erosion, Multifocal                  |                               3                          3               |             
      Mucosa, Muscularis, Mineralization   |                                                                          |             
                                            __________________________________________________________________________|             
   Tongue                                  |                   +           +                    +                 +   |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +|             
      Cardiomyopathy, Chronic              |    3  2  2  2     2  1  2  1  2  2  2     1  1              2            |             
      Artery, Mineralization               |                                                                          |             
      Atrium, Thrombosis                   |                      X        X              X  X        X  X  X         |             
      Epicardium, Inflammation, Chronic    |                                                                          |             
          Active, Focal                    |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +|             
      Congestion                           |                                                                          |             
      Hyperplasia, Focal                   |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +|             
      Congestion                           |                                                                          |             
      Hyperplasia, Focal                   |                                  1  2                                    |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                  1  2           2                        |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +|             
      Pars Distalis, Cyst                  |                         X                                               2|             
      Pars Distalis, Hyperplasia, Focal    |                                                       2                  |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +|             
      C-Cell, Hyperplasia, Focal           |                                                             1           1|             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Preputial Gland                         | +  +  +  M  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  66                                                               
NTP Experiment-Test: 05172-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                               3,3-DIMETHOXYBENZIDINE DIHYDROCHLORIDE                          Date: 04/30/97  
Route: DOSED WATER                                                                                                Time: 17:38:14  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 5| 5| 4| 3| 6| 6| 6| 6| 4| 6| 6| 6| 5| 2| 6| 6| 6| 5| 5| 6| 5| 5| 4| 4|             
                             DAY ON TEST   | 4| 9| 5| 8| 5| 4| 4| 1| 1| 8| 1| 0| 0| 4| 6| 4| 1| 0| 9| 7| 1| 3| 1| 8| 8|             
                                           | 4| 6| 2| 0| 3| 4| 7| 8| 8| 3| 0| 3| 3| 6| 2| 1| 1| 2| 6| 8| 8| 8| 5| 5| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    80 PPM                                 | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
      Atrophy                              |                                                 3     3                  |             
      Ectasia                              |                3     3                       4     4           3     3  3|             
      Hyperplasia, Focal                   |                   2                                                      |             
      Hyperplasia, Focal, Squamous         |                                                                          |             
      Hyperplasia                          |                                                             1            |             
      Hyperplasia, Squamous                |                2                                                         |             
                                            __________________________________________________________________________|             
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Focal, Glandular        |                                              2                           |             
      Hyperplasia, Glandular, Multifocal   |                   2              2                                       |             
      Inflammation, Chronic Active         |                                                          2        2      |             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         | +  +  +  +  M  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                4                                   4                     |             
      Interstitial Cell, Hyperplasia       |          2     2                                                     2   |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          | 3                                                                        |             
      Myelofibrosis, Focal                 |                                                    1                     |             
      Myeloid Cell, Hyperplasia            |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +     +  +  A  +  +  +  +  +  +  +  +  +  +  +|             
      Axillary, Congestion                 |                                                                          |             
      Axillary, Erythrophagocytosis        |                                                                          |             
      Mediastinal, Congestion              |             2                                                  3         |             
      Mediastinal, Hyperplasia, Lymphoid   |                                                                          |             
      Mediastinal, Pigmentation            |                                                                          |             
      Pancreatic, Hyperplasia, Lymphoid    |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +     +  +  A  +  +  +  +  +  +  +  +  +  +  +|             
      Congestion                           |                                                                          |             
      Erythrophagocytosis                  |                                                                          |             
      Hyperplasia, Lymphoid                |                            3                                             |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +     +  +  A  +  +  +  +  +  +  +  +  +  +  +|             
      Congestion                           |                                                                          |             
      Hyperplasia, Lymphoid                |                                                                          |             
      Hyperplasia, Reticulum Cell          |    3                                               3                     |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +|             
      Hematopoietic Cell Proliferation     |                3     3     3  4     2           3  3        3           2|             
                                            __________________________________________________________________________|             
   Thymus                                  | +  M  M  +  +  M  M  +  +  +  +  +  M  A  +  +  +  +  +  +  +  +  M  +  +|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  M|             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst Epithelial Inclusion            |                                                                      X   |             
      Hyperkeratosis, Focal                |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  67                                                               
NTP Experiment-Test: 05172-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                               3,3-DIMETHOXYBENZIDINE DIHYDROCHLORIDE                          Date: 04/30/97  
Route: DOSED WATER                                                                                                Time: 17:38:14  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 5| 5| 4| 3| 6| 6| 6| 6| 4| 6| 6| 6| 5| 2| 6| 6| 6| 5| 5| 6| 5| 5| 4| 4|             
                             DAY ON TEST   | 4| 9| 5| 8| 5| 4| 4| 1| 1| 8| 1| 0| 0| 4| 6| 4| 1| 0| 9| 7| 1| 3| 1| 8| 8|             
                                           | 4| 6| 2| 0| 3| 4| 7| 8| 8| 3| 0| 3| 3| 6| 2| 1| 1| 2| 6| 8| 8| 8| 5| 5| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    80 PPM                                 | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Inflammation, Chronic, Focal         |                3                                                         |             
      Necrosis                             |                                                                         4|             
      Hair Follicle, Hyperplasia, Basal    |                                                                          |             
          Cell, Focal                      |                                                                         3|             
      Subcutaneous Tissue, Edema           |                               3                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    |                                                                         +|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +|             
      Congestion                           |                                                                          |             
      Hyperplasia, Lymphoid                | 2  2     2  2  2  2  2  2  2  2  2  2     2        2        2  2     2   |             
      Infiltration Cellular, Histiocyte    |                2                                3              2         |             
      Thrombosis, Multiple                 |                                                 X                        |             
      Alveolar Epithelium, Hyperplasia,    |                                                                          |             
           Focal                           |                                                                          |             
      Alveolar Epithelium, Hyperplasia,    |                                                                          |             
           Multifocal                      |                                                                          |             
      Artery, Mediastinum, Mineralization  |                                                                          |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +|             
      Fungus                               |       4                                                  4               |             
      Inflammation, Acute                  |       4                                                  2               |             
      Inflammation, Chronic                |                                                                          |             
      Necrosis, Focal                      |       4                                                                  |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                                                                +        +|             
      Anterior Chamber, Cornea,            |                                                                          |             
          Inflammation, Acute              |                                                                         3|             
                                            __________________________________________________________________________|             
   Zymbal's Gland                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Ectasia                              | 3  3  3  2  2  4  2  1  2     2  2  1  2  2  2  1  1  2  3  2  2  2      |             
      Hyperplasia, Diffuse                 |                                                                          |             
      Hyperplasia, Focal                   |                            2        1                                    |             
      Hyperplasia, Focal, Squamous         | 1                                                                        |             
      Hypertrophy, Diffuse                 |                   3                                                      |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +|             
      Infarct, Chronic                     |                                                 4                        |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  68                                                               
NTP Experiment-Test: 05172-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                               3,3-DIMETHOXYBENZIDINE DIHYDROCHLORIDE                          Date: 04/30/97  
Route: DOSED WATER                                                                                                Time: 17:38:14  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 5| 5| 4| 3| 6| 6| 6| 6| 4| 6| 6| 6| 5| 2| 6| 6| 6| 5| 5| 6| 5| 5| 4| 4|             
                             DAY ON TEST   | 4| 9| 5| 8| 5| 4| 4| 1| 1| 8| 1| 0| 0| 4| 6| 4| 1| 0| 9| 7| 1| 3| 1| 8| 8|             
                                           | 4| 6| 2| 0| 3| 4| 7| 8| 8| 3| 0| 3| 3| 6| 2| 1| 1| 2| 6| 8| 8| 8| 5| 5| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    80 PPM                                 | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
      Mineralization                       |                                                                          |             
      Nephropathy, Chronic                 | 3  2  2  2     3  3  3  2  2  3     2     1  1  3     2  2  2     2  1  2|             
      Renal Tubule, Degeneration           |                                                                          |             
      Renal Tubule, Pigmentation           |       3                                                                  |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  69                                                               
NTP Experiment-Test: 05172-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                               3,3-DIMETHOXYBENZIDINE DIHYDROCHLORIDE                          Date: 04/30/97  
Route: DOSED WATER                                                                                                Time: 17:38:14  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 6| 6| 5| 5| 6| 6| 5| 5| 3| 6| 6| 5| 5| 5| 6| 6| 6| 6| 6|              |            |
                             DAY ON TEST   | 4| 1| 0| 9| 5| 4| 4| 8| 5| 5| 0| 0| 9| 8| 5| 4| 4| 4| 4| 3|              |            |
                                           | 7| 8| 9| 5| 6| 7| 7| 5| 6| 4| 6| 4| 3| 8| 8| 7| 7| 7| 7| 8|              |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|              |      A     |
    80 PPM                                 | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|              |      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|              |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  44        |
      Hyperkeratosis                       |                            2                                             |      1  2.0|
                                            __________________________________________________________________________|____________|
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +               |  43        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  A  A  +  +  +  +  +               |  42        |
      Mucosa, Necrosis, Focal              |    3                                                                     |      1  3.0|
      Submucosa, Edema                     |    3                                                                     |      1  3.0|
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +               |  43        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  A  A  +  +  +  +  +               |  42        |
      Parasite Metazoan                    |                            1                                             |      1  1.0|
                                            __________________________________________________________________________|____________|
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +  +  +  +  A  A  +  +  +  +  +               |  42        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  A  A  +  +  +  +  +               |  42        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  A  A  +  +  +  +  +               |  42        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  A  A  +  +  +  +  +               |  41        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  45        |
      Basophilic Focus                     | 2     1     1  2  2  3     1     2  2        1  1        1               |     29  1.5|
      Clear Cell Focus                     |                            1     1  2        1  1  X  1                  |     11  1.1|
      Degeneration, Cystic, Focal          |                1                                                         |      1  1.0|
      Degeneration, Cystic                 | 1  3        2     2     2     3  1  2  2                 2               |     21  2.0|
      Degeneration, Cystic, Multifocal     |                      2                                                   |      1  2.0|
      Ectasia, Multifocal                  |             2                                                            |      1  2.0|
      Eosinophilic Focus                   | 2           2  3     2  2           2                 1                  |     15  1.7|
      Granuloma                            |                                                                          |      2  2.5|
      Hematopoietic Cell Proliferation     |                2           1     1  1              1  2                  |     15  1.3|
      Hepatodiaphragmatic Nodule           |          X                                                               |      3     |
      Hepatodiaphragmatic Nodule, Multiple |                   X                                                      |      1     |
      Infarct, Chronic                     |                                                                          |      2  3.5|
      Necrosis, Coagulative                |                                                                          |      1  2.0|
      Necrosis, Focal                      |                                                                          |      1  1.0|
      Regeneration, Diffuse                |    4                                                                     |      1  4.0|
      Regeneration, Focal                  |                                        4                                 |      1  4.0|
      Regeneration, Multifocal             | 3                 3     4     4                                          |      5  3.2|
      Thrombosis                           |                                     X                                    |      3     |
      Vacuolization Cytoplasmic, Multifocal|                                                 2                        |      2  1.5|
      Bile Duct, Hyperplasia               |    3                                                                     |      2  2.5|
      Centrilobular, Degeneration, Diffuse |    4        1                                         1                  |      4  1.8|
      Centrilobular, Necrosis, Diffuse     |                               3        2                 2               |      7  3.1|
      Centrilobular, Necrosis, Focal       | 2                                                                        |      1  2.0|
      Centrilobular, Necrosis              |                                     2                                    |      3  2.0|
      Centrilobular, Necrosis, Multifocal  |       3                 2                                                |      2  2.5|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  70                                                               
NTP Experiment-Test: 05172-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                               3,3-DIMETHOXYBENZIDINE DIHYDROCHLORIDE                          Date: 04/30/97  
Route: DOSED WATER                                                                                                Time: 17:38:14  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 6| 6| 5| 5| 6| 6| 5| 5| 3| 6| 6| 5| 5| 5| 6| 6| 6| 6| 6|              |            |
                             DAY ON TEST   | 4| 1| 0| 9| 5| 4| 4| 8| 5| 5| 0| 0| 9| 8| 5| 4| 4| 4| 4| 3|              |            |
                                           | 7| 8| 9| 5| 6| 7| 7| 5| 6| 4| 6| 4| 3| 8| 8| 7| 7| 7| 7| 8|              |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|              |      A     |
    80 PPM                                 | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|              |      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|              |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mesentery                               |       +              +           +  +        +                           |   9        |
      Artery, Mineralization               |                      4                                                   |      1  4.0|
      Fat, Necrosis                        |       3                          3  3        3                           |      8  3.0|
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  44        |
      Atrophy                              | 3                       2                                                |      4  2.3|
      Acinus, Hypertrophy, Multifocal      |       2                                                                  |      1  2.0|
                                            __________________________________________________________________________|____________|
   Pharynx                                 | +                       +           +                                    |   4        |
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  44        |
      Atrophy                              |    2                                                                     |      1  2.0|
      Interlobular, Edema                  |             4                                                            |      1  4.0|
      Parotid Gland, Atrophy               |                      3                                                   |      1  3.0|
                                            __________________________________________________________________________|____________|
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  44        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  44        |
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  44        |
      Erosion, Multifocal                  |    4                          3     2                                    |      5  3.0|
      Mucosa, Muscularis, Mineralization   |                      4                                                   |      1  4.0|
                                            __________________________________________________________________________|____________|
   Tongue                                  |                                                                          |   4        |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  44        |
      Cardiomyopathy, Chronic              | 2           2  2  2  2  2  1  2  2  2  2  2  2        2  2               |     29  1.9|
      Artery, Mineralization               |                      3                                                   |      1  3.0|
      Atrium, Thrombosis                   |    X           X              X     X     X        X  X  X               |     15     |
      Epicardium, Inflammation, Chronic    |                                                                          |            |
          Active, Focal                    |                                  3                                       |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  44        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  44        |
      Congestion                           |                                        3                                 |      1  3.0|
      Hyperplasia, Focal                   |                                                    2                     |      1  2.0|
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  44        |
      Congestion                           |                                        3                                 |      1  3.0|
      Hyperplasia, Focal                   |                         1     1                                          |      4  1.3|
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  44        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  43        |
      Hyperplasia                          |                      2                                                   |      4  1.8|
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +               |  43        |
      Pars Distalis, Cyst                  |                                                                          |      2  2.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  71                                                               
NTP Experiment-Test: 05172-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                               3,3-DIMETHOXYBENZIDINE DIHYDROCHLORIDE                          Date: 04/30/97  
Route: DOSED WATER                                                                                                Time: 17:38:14  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 6| 6| 5| 5| 6| 6| 5| 5| 3| 6| 6| 5| 5| 5| 6| 6| 6| 6| 6|              |            |
                             DAY ON TEST   | 4| 1| 0| 9| 5| 4| 4| 8| 5| 5| 0| 0| 9| 8| 5| 4| 4| 4| 4| 3|              |            |
                                           | 7| 8| 9| 5| 6| 7| 7| 5| 6| 4| 6| 4| 3| 8| 8| 7| 7| 7| 7| 8|              |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|              |      A     |
    80 PPM                                 | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|              |      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|              |            |
 __________________________________________________________________________________________________________________________________ 
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
                                           |                                                                          |            |
      Pars Distalis, Hyperplasia, Focal    |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  44        |
      C-Cell, Hyperplasia, Focal           | 1                                               1                        |      4  1.0|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  45        |
                                            __________________________________________________________________________|____________|
   Preputial Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  43        |
      Atrophy                              |    3     3  3     3  3        3                                          |      8  3.0|
      Ectasia                              |                                  4  3     3           4  3               |     12  3.3|
      Hyperplasia, Focal                   |                                              3                           |      2  2.5|
      Hyperplasia, Focal, Squamous         |                            1        2              2                     |      3  1.7|
      Hyperplasia                          |                                                                          |      1  1.0|
      Hyperplasia, Squamous                |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  44        |
      Hyperplasia, Focal, Glandular        |                                              1                           |      2  1.5|
      Hyperplasia, Glandular, Multifocal   |                1  2                                                      |      4  1.8|
      Inflammation, Chronic Active         |                                                                          |      2  2.0|
                                            __________________________________________________________________________|____________|
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +               |  42        |
                                            __________________________________________________________________________|____________|
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  45        |
      Atrophy                              |                                  4                 3                     |      4  3.8|
      Interstitial Cell, Hyperplasia       |                            2                                             |      4  2.0|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +               |  43        |
      Hyperplasia                          |             2  2                                                         |      3  2.3|
      Myelofibrosis, Focal                 |                                                                          |      1  1.0|
      Myeloid Cell, Hyperplasia            |                            3                                             |      1  3.0|
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  43        |
      Axillary, Congestion                 |             3                                                            |      1  3.0|
      Axillary, Erythrophagocytosis        |    3                                                                     |      1  3.0|
      Mediastinal, Congestion              |                            2                                             |      3  2.3|
      Mediastinal, Hyperplasia, Lymphoid   |                               3                                          |      1  3.0|
      Mediastinal, Pigmentation            |                                                 4                        |      1  4.0|
      Pancreatic, Hyperplasia, Lymphoid    |                            3                                             |      1  3.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  43        |
      Congestion                           |             3                                                            |      1  3.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  72                                                               
NTP Experiment-Test: 05172-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                               3,3-DIMETHOXYBENZIDINE DIHYDROCHLORIDE                          Date: 04/30/97  
Route: DOSED WATER                                                                                                Time: 17:38:14  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 6| 6| 5| 5| 6| 6| 5| 5| 3| 6| 6| 5| 5| 5| 6| 6| 6| 6| 6|              |            |
                             DAY ON TEST   | 4| 1| 0| 9| 5| 4| 4| 8| 5| 5| 0| 0| 9| 8| 5| 4| 4| 4| 4| 3|              |            |
                                           | 7| 8| 9| 5| 6| 7| 7| 5| 6| 4| 6| 4| 3| 8| 8| 7| 7| 7| 7| 8|              |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|              |      A     |
    80 PPM                                 | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|              |      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|              |            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
      Erythrophagocytosis                  |    3                                                                     |      1  3.0|
      Hyperplasia, Lymphoid                |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +               |  42        |
      Congestion                           |             3                                                            |      1  3.0|
      Hyperplasia, Lymphoid                |                                           3                              |      1  3.0|
      Hyperplasia, Reticulum Cell          |                                                       3                  |      3  3.0|
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  A  A  +  +  +  +  +               |  42        |
      Hematopoietic Cell Proliferation     |                3           3        4                 2                  |     13  2.9|
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +  M  +  +  +  +  +  +  +  +  M  +  M  +  +  +  +  +  M               |  34        |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  42        |
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  45        |
      Cyst Epithelial Inclusion            |                   X                                                      |      2     |
      Hyperkeratosis, Focal                |                                                       2                  |      1  2.0|
      Inflammation, Chronic, Focal         |                                                                          |      1  3.0|
      Necrosis                             |                                                                          |      1  4.0|
      Hair Follicle, Hyperplasia, Basal    |                                                                          |            |
          Cell, Focal                      |                                                                          |      1  3.0|
      Subcutaneous Tissue, Edema           |    3        3                                                            |      3  3.0|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    |          +                                      +                        |   3        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +               |  44        |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  44        |
      Congestion                           |                                                          3               |      1  3.0|
      Hyperplasia, Lymphoid                | 2           2  2  2  2     2     2  2  3     3     2  2                  |     29  2.1|
      Infiltration Cellular, Histiocyte    |                                                                          |      3  2.3|
      Thrombosis, Multiple                 |                                                                          |      1     |
      Alveolar Epithelium, Hyperplasia,    |                                                                          |            |
           Focal                           |    3                                                                     |      1  3.0|
      Alveolar Epithelium, Hyperplasia,    |                                                                          |            |
           Multifocal                      |                                              3                           |      1  3.0|
      Artery, Mediastinum, Mineralization  |                      3                                                   |      1  3.0|
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  44        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  73                                                               
NTP Experiment-Test: 05172-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                               3,3-DIMETHOXYBENZIDINE DIHYDROCHLORIDE                          Date: 04/30/97  
Route: DOSED WATER                                                                                                Time: 17:38:14  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 6| 6| 5| 5| 6| 6| 5| 5| 3| 6| 6| 5| 5| 5| 6| 6| 6| 6| 6|              |            |
                             DAY ON TEST   | 4| 1| 0| 9| 5| 4| 4| 8| 5| 5| 0| 0| 9| 8| 5| 4| 4| 4| 4| 3|              |            |
                                           | 7| 8| 9| 5| 6| 7| 7| 5| 6| 4| 6| 4| 3| 8| 8| 7| 7| 7| 7| 8|              |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|              |      A     |
    80 PPM                                 | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|              |      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|              |            |
 __________________________________________________________________________________________________________________________________ 
 RESPIRATORY SYSTEM - cont                 |                                                                          |            |
                                           |                                                                          |            |
      Fungus                               |                                        3                                 |      3  3.7|
      Inflammation, Acute                  |                                        2                                 |      3  2.7|
      Inflammation, Chronic                |                                              2                           |      1  2.0|
      Necrosis, Focal                      |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +               |  43        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Eye                                     |          +                                                               |   3        |
      Anterior Chamber, Cornea,            |                                                                          |            |
          Inflammation, Acute              |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Zymbal's Gland                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  45        |
      Ectasia                              | 2  2  1  4  4     2  2  2     4  2  2  2  2  2  3  2  1  2               |     40  2.2|
      Hyperplasia, Diffuse                 |                            2                 3                           |      2  2.5|
      Hyperplasia, Focal                   |                2                                                         |      3  1.7|
      Hyperplasia, Focal, Squamous         |                         1        2                 1                     |      4  1.3|
      Hypertrophy, Diffuse                 |                                                                          |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  44        |
      Infarct, Chronic                     |                                                                          |      1  4.0|
      Mineralization                       |                      4                                                   |      1  4.0|
      Nephropathy, Chronic                 | 3  2  2     2  3  3     1  2  2  2  2  2     3  3  2  2                  |     36  2.2|
      Renal Tubule, Degeneration           |                      3                                                   |      1  3.0|
      Renal Tubule, Pigmentation           |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  44        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  74                                                               
NTP Experiment-Test: 05172-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                               3,3-DIMETHOXYBENZIDINE DIHYDROCHLORIDE                          Date: 04/30/97  
Route: DOSED WATER                                                                                                Time: 17:38:14  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 5| 5| 3| 3| 6| 5| 5| 5| 4| 5| 5| 5| 4| 4| 6| 5| 4| 3| 3| 6| 5| 5| 5| 4|             
                             DAY ON TEST   | 9| 3| 2| 9| 0| 3| 7| 6| 5| 8| 9| 6| 6| 7| 1| 4| 4| 7| 9| 3| 1| 5| 3| 3| 2|             
                                           | 1| 1| 5| 1| 4| 4| 8| 2| 6| 5| 4| 0| 1| 2| 7| 1| 1| 6| 1| 9| 6| 5| 9| 6| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
    170 PPM                                | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +|             
      Congestion                           |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Parasite Metazoan                    |             X                                                            |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Parasite Metazoan                    |             X                                                            |             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +|             
      Mucosa, Hyperplasia, Diffuse         |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  A  +  +  +  +  +  +  +  +  +  +  A  +  +  +  A  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +|             
      Congestion                           |                                                                          |             
      Mucosa, Hyperplasia, Focal           |                                                                          |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Basophilic Focus                     | 2     4     2     1  1  2     1  1  3  2  1     1     2     1     3  1   |             
      Clear Cell Focus                     |             2        2                       2           2               |             
      Degeneration, Cystic, Focal          |                      1                                                   |             
      Degeneration, Cystic                 |    1  1           1     2     1  1           2     1        2        1   |             
      Degeneration, Cystic, Multifocal     |                                                                          |             
      Ectasia, Multifocal                  |                                                                          |             
      Eosinophilic Focus                   | 2                 1  2  2        3  3  1        2           1        2   |             
      Fatty Change                         |                               3                                          |             
      Hematopoietic Cell Proliferation     | 2  1           1     2        2  2  2  1        2        1  1     1  2   |             
      Hepatodiaphragmatic Nodule           |                                                                          |             
      Necrosis, Coagulative                |                                                                          |             
      Necrosis, Focal                      |                                        1                                 |             
      Necrosis, Multifocal                 |                   2     2     3                                          |             
      Regeneration, Diffuse                | 3  2                          3                       4                  |             
      Regeneration, Focal                  |                      4                                                   |             
      Regeneration, Multifocal             |                2  4                          3                           |             
      Thrombosis                           | X                             X                                          |             
      Vacuolization Cytoplasmic, Multifocal|                                                                          |             
      Bile Duct, Hyperplasia               | 2  2                          2                       4                  |             
      Caudate Lobe, Pigmentation           |                                                                          |             
      Caudate Lobe, Regeneration           |                                                                          |             
      Centrilobular, Degeneration, Diffuse | 2                             3                                          |             
      Centrilobular, Necrosis, Diffuse     |    4                                      3                              |             
      Centrilobular, Necrosis              |                                                       4                  |             
      Periportal, Fibrosis                 |                                                       4                  |             
                                            __________________________________________________________________________|             
   Mesentery                               | +                    +  +  +        +           +  +        +     +     +|             
      Ectasia, Focal                       |                                                                          |             
      Fat, Necrosis                        | 4                    3  3  3        3              3        3     3      |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  75                                                               
NTP Experiment-Test: 05172-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                               3,3-DIMETHOXYBENZIDINE DIHYDROCHLORIDE                          Date: 04/30/97  
Route: DOSED WATER                                                                                                Time: 17:38:14  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 5| 5| 3| 3| 6| 5| 5| 5| 4| 5| 5| 5| 4| 4| 6| 5| 4| 3| 3| 6| 5| 5| 5| 4|             
                             DAY ON TEST   | 9| 3| 2| 9| 0| 3| 7| 6| 5| 8| 9| 6| 6| 7| 1| 4| 4| 7| 9| 3| 1| 5| 3| 3| 2|             
                                           | 1| 1| 5| 1| 4| 4| 8| 2| 6| 5| 4| 0| 1| 2| 7| 1| 1| 6| 1| 9| 6| 5| 9| 6| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
    170 PPM                                | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
                                           |                                                                          |             
      Vein, Ectasia                        |                                                                          |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                                  2                                       |             
                                            __________________________________________________________________________|             
   Pharynx                                 |                                                                          |             
      Palate, Hyperplasia, Focal, Squamous |                                                                          |             
      Palate, Hyperplasia, Squamous        |                                                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +|             
      Acanthosis                           |                                                    2                     |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +     +  A  +  +  +  +  +  +|             
      Erosion, Focal                       |                               2                                          |             
      Erosion, Multifocal                  |    3                                                                     |             
      Hemorrhage, Multifocal               |                                                                          |             
      Mineralization                       |                                                                          |             
                                            __________________________________________________________________________|             
   Tongue                                  |                         +                                                |             
      Necrosis, Focal                      |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cardiomyopathy, Chronic              |    2     2  1  2  1  2  2  2           2  2        2  2  2     3  2  2  2|             
      Inflammation, Acute, Multifocal      |                                                                          |             
      Atrium, Thrombosis                   | X  X           X              X  X  X           X                        |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                                                             4            |             
      Hyperplasia, Focal                   |                                                                          |             
      Necrosis, Multifocal                 |                                                                          |             
      Pigmentation                         |                                                             4            |             
      Vacuolization Cytoplasmic, Diffuse   |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                                                             4            |             
      Hyperplasia, Focal                   |             2                                   2                        |             
      Hyperplasia, Multifocal              |    3                          2     1                                    |             
      Pigmentation                         |                                                             4            |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Focal                   |                                                                          |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                                                          |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +|             
      Pars Distalis, Angiectasis           |                                                                          |             
      Pars Distalis, Congestion            |                                                       2                  |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  76                                                               
NTP Experiment-Test: 05172-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                               3,3-DIMETHOXYBENZIDINE DIHYDROCHLORIDE                          Date: 04/30/97  
Route: DOSED WATER                                                                                                Time: 17:38:14  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 5| 5| 3| 3| 6| 5| 5| 5| 4| 5| 5| 5| 4| 4| 6| 5| 4| 3| 3| 6| 5| 5| 5| 4|             
                             DAY ON TEST   | 9| 3| 2| 9| 0| 3| 7| 6| 5| 8| 9| 6| 6| 7| 1| 4| 4| 7| 9| 3| 1| 5| 3| 3| 2|             
                                           | 1| 1| 5| 1| 4| 4| 8| 2| 6| 5| 4| 0| 1| 2| 7| 1| 1| 6| 1| 9| 6| 5| 9| 6| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
    170 PPM                                | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
      Pars Distalis, Cyst                  |                                                                          |             
      Pars Distalis, Hyperplasia, Focal    |                                                                          |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      C-Cell, Hyperplasia, Focal           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Tissue NOS                              |                                                          +               |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atypia Cellular                      |                                                       3                  |             
                                            __________________________________________________________________________|             
   Preputial Gland                         | +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              | 3                    3                                                   |             
      Cyst                                 |                                                                          |             
      Ectasia                              | 3              3  4  3     2              3  4     2              3  3   |             
      Hyperplasia, Focal                   |                                                                          |             
      Hyperplasia, Focal, Squamous         |    1        1              1                                             |             
      Hyperplasia, Multifocal, Squamous    |                                                                          |             
      Inflammation, Acute                  |                                  3                                   4   |             
      Inflammation, Chronic                |                                                                          |             
      Inflammation, Chronic Active         |                                                                          |             
                                            __________________________________________________________________________|             
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Focal, Glandular        |       2                                                                  |             
      Hyperplasia, Glandular, Multifocal   |                2                                            2            |             
      Inflammation, Acute                  |          3                                            2                  |             
      Inflammation, Chronic                |                                                                         2|             
      Inflammation, Chronic Active         |    2                       4                       4              4      |             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         | +  +  +  M  M  +  +  +  +  +  +  +  +  M  M  +  +  M  M  M  +  +  +  +  M|             
      Atrophy                              |                                                                          |             
      Inflammation, Chronic Active         |                                                                   4      |             
      Epithelium, Hyperplasia, Focal       |    1                                                                     |             
                                            __________________________________________________________________________|             
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                                                       2                  |             
      Cyst                                 |                                                                          |             
      Degeneration                         |                                                                         3|             
      Interstitial Cell, Hyperplasia       |    2                       2           2  2                              |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                   2     2           3                       3            |             
      Hypoplasia                           |                                                       2                  |             
      Myelofibrosis, Focal                 |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Axillary, Hemorrhage                 |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  77                                                               
NTP Experiment-Test: 05172-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                               3,3-DIMETHOXYBENZIDINE DIHYDROCHLORIDE                          Date: 04/30/97  
Route: DOSED WATER                                                                                                Time: 17:38:14  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 5| 5| 3| 3| 6| 5| 5| 5| 4| 5| 5| 5| 4| 4| 6| 5| 4| 3| 3| 6| 5| 5| 5| 4|             
                             DAY ON TEST   | 9| 3| 2| 9| 0| 3| 7| 6| 5| 8| 9| 6| 6| 7| 1| 4| 4| 7| 9| 3| 1| 5| 3| 3| 2|             
                                           | 1| 1| 5| 1| 4| 4| 8| 2| 6| 5| 4| 0| 1| 2| 7| 1| 1| 6| 1| 9| 6| 5| 9| 6| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
    170 PPM                                | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Axillary, Hyperplasia, Lymphoid      |                                                                          |             
      Iliac, Hyperplasia, Lymphoid         |                                                                          |             
      Inguinal, Necrosis                   |                                                                          |             
      Mediastinal, Atrophy                 |    3                                                                     |             
      Mediastinal, Congestion              |                                           3                              |             
      Mediastinal, Hemorrhage              |                                                                          |             
      Mediastinal, Hyperplasia, Lymphoid   |                                                                          |             
      Mediastinal, Pigmentation            |                                                 4                        |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Congestion                           |                                                                          |             
      Hyperplasia, Lymphoid                |                                                                          |             
      Hyperplasia, Reticulum Cell          |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +|             
      Hyperplasia, Lymphoid                |       4                                                                  |             
      Hyperplasia, Reticulum Cell          |             2                          3                 1               |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                                                                         3|             
      Hematopoietic Cell Proliferation     |    3  4              3  3     3  3  3  3  4     2           3            |             
      Hyperplasia, Reticulum Cell          | 4                                                                        |             
      Necrosis                             |                                                       3                  |             
      Pigmentation, Hemosiderin            |                                                                          |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  M  +  M  M  +  M  +  +  +  +  +  +  +  +  +  M  +  +  +|             
      Atrophy                              |                                                       2                  |             
      Edema                                |                                                       4                  |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Abscess                              |                3                                                         |             
      Acanthosis, Focal                    |                                                                          |             
      Cyst Epithelial Inclusion            |                                                                          |             
      Granuloma, Focal                     |                      4                                                   |             
      Hyperkeratosis, Focal                |                                                                          |             
      Dermis, Fibrosis, Focal              |                                                                          |             
      Hair Follicle, Hyperplasia, Basal    |                                                                          |             
          Cell, Focal                      |                                                                          |             
      Subcutaneous Tissue, Edema           | 3                                                           3            |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    |                                                                          |             
      Cranium, Proliferation, Focal        |                                                                          |             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |                                                                         +|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  78                                                               
NTP Experiment-Test: 05172-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                               3,3-DIMETHOXYBENZIDINE DIHYDROCHLORIDE                          Date: 04/30/97  
Route: DOSED WATER                                                                                                Time: 17:38:14  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 5| 5| 3| 3| 6| 5| 5| 5| 4| 5| 5| 5| 4| 4| 6| 5| 4| 3| 3| 6| 5| 5| 5| 4|             
                             DAY ON TEST   | 9| 3| 2| 9| 0| 3| 7| 6| 5| 8| 9| 6| 6| 7| 1| 4| 4| 7| 9| 3| 1| 5| 3| 3| 2|             
                                           | 1| 1| 5| 1| 4| 4| 8| 2| 6| 5| 4| 0| 1| 2| 7| 1| 1| 6| 1| 9| 6| 5| 9| 6| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
    170 PPM                                | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cerebrum, Hemorrhage                 |                            1                          2                  |             
      Cerebrum, Thrombosis, Multifocal     |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Congestion                           |                               3                                          |             
      Edema                                |                                                                          |             
      Hemorrhage                           |                                                       1                  |             
      Hyperplasia, Lymphoid                | 2  2  3  2  2  2     2  2        2  2  2  2     2  2     2  2  2  2     2|             
      Infiltration Cellular, Histiocyte    |                      2        3  1                    2                  |             
      Pigmentation, Focal                  |    3                                                                     |             
      Alveolar Epithelium, Hyperplasia,    |                                                                          |             
           Focal                           | 2                                               3                 1      |             
      Alveolar Epithelium, Hyperplasia,    |                                                                          |             
           Multifocal                      |       3                       2                                          |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fungus                               |                   3     4                                   3            |             
      Hyperkeratosis                       |                                                             3            |             
      Inflammation, Acute                  |                   3     4                                   2            |             
      Inflammation, Chronic                |                                                                          |             
      Necrosis, Focal                      |                                                                          |             
      Necrosis, Multifocal                 |                                                                          |             
      Mucosa, Hyperplasia                  |                                                                          |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                                              +                           |             
      Cataract                             |                                              3                           |             
      Retina, Degeneration                 |                                              4                           |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                                        +                                 |             
                                            __________________________________________________________________________|             
   Zymbal's Gland                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Ectasia, Focal                       |                   2                                                      |             
      Ectasia                              |    2  1  2  2  2     2     2        3  2  2  2  2     1  1     3  2  2  1|             
      Hyperplasia, Focal                   |    1                                                                     |             
      Hyperplasia, Focal, Squamous         |                                                 2                        |             
      Hyperplasia, Squamous                |       1                                                                  |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hydronephrosis                       |                                                                   3      |             
      Nephropathy, Chronic                 | 2  1  1     2  3  2  2  2  2     3  1  1     4     3     2  2     3  2   |             
      Thrombosis, Multifocal               |                                                                          |             
      Cortex, Infarct, Acute               |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  79                                                               
NTP Experiment-Test: 05172-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                               3,3-DIMETHOXYBENZIDINE DIHYDROCHLORIDE                          Date: 04/30/97  
Route: DOSED WATER                                                                                                Time: 17:38:14  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 5| 5| 3| 3| 6| 5| 5| 5| 4| 5| 5| 5| 4| 4| 6| 5| 4| 3| 3| 6| 5| 5| 5| 4|             
                             DAY ON TEST   | 9| 3| 2| 9| 0| 3| 7| 6| 5| 8| 9| 6| 6| 7| 1| 4| 4| 7| 9| 3| 1| 5| 3| 3| 2|             
                                           | 1| 1| 5| 1| 4| 4| 8| 2| 6| 5| 4| 0| 1| 2| 7| 1| 1| 6| 1| 9| 6| 5| 9| 6| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
    170 PPM                                | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
      Proximal Convoluted Renal Tubule,    |                                                                          |             
           Necrosis, Diffuse               |                                                                          |             
      Renal Tubule, Mineralization         |                                                                          |             
      Renal Tubule, Pigmentation           |                                                 3                        |             
      Transitional Epithelium, Hyperplasia,|                                                                          |             
           Focal                           |                                                                          |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |          4                                                              4|             
      Inflammation, Acute                  |          4                                                        4     4|             
      Necrosis, Diffuse                    |                                                                   4     4|             
      Necrosis, Focal                      |                                                    3                     |             
      Mucosa, Hyperplasia                  |                                                                   4      |             
      Serosa, Cyst                         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  80                                                               
NTP Experiment-Test: 05172-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                               3,3-DIMETHOXYBENZIDINE DIHYDROCHLORIDE                          Date: 04/30/97  
Route: DOSED WATER                                                                                                Time: 17:38:14  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 5| 4| 4| 4| 5| 5| 5| 4| 4| 6| 5| 5| 5| 4| 5| 5| 5| 5| 2| 6| 5| 5| 4| 4|             
                             DAY ON TEST   | 1| 6| 8| 8| 0| 6| 7| 4| 6| 2| 0| 5| 4| 2| 8| 6| 6| 6| 5| 8| 1| 6| 3| 8| 8|             
                                           | 6| 1| 3| 3| 8| 2| 8| 6| 7| 4| 4| 3| 6| 6| 5| 1| 1| 1| 6| 4| 6| 0| 8| 6| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
    170 PPM                                | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +|             
      Congestion                           |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +|             
      Parasite Metazoan                    |       X                                                                  |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +|             
      Parasite Metazoan                    |       X     X                                            1               |             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +  +  +  +  +  +  A  +  +  A  A  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  A  +  +  A  A  +  +  +  +  +  +  +  +  +  +  +  +|             
      Mucosa, Hyperplasia, Diffuse         |                                                    3                     |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  A  +  +  A  A  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  A  +  +  A  A  +  +  +  +  +  +  +  +  +  +  +  +|             
      Congestion                           |                                                                          |             
      Mucosa, Hyperplasia, Focal           |                                                                          |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Basophilic Focus                     |    2     1     2  2  3     3  2  2  2     2  1  1  3     2  2        2   |             
      Clear Cell Focus                     |       2  2  2     2                    2                    2        2   |             
      Degeneration, Cystic, Focal          |    3                                                                     |             
      Degeneration, Cystic                 | 1              2        1     1              1  1           1  2  1      |             
      Degeneration, Cystic, Multifocal     |                   2                                2                     |             
      Ectasia, Multifocal                  |                2                                                         |             
      Eosinophilic Focus                   |    3  2  2     3           2        3  1     2  1  2  2     1  2     2   |             
      Fatty Change                         |       1                                3                                 |             
      Hematopoietic Cell Proliferation     | 1  3  2        1  1        1  1  1           1  3  1        2            |             
      Hepatodiaphragmatic Nodule           |                                                          X               |             
      Necrosis, Coagulative                |                            3                                             |             
      Necrosis, Focal                      |                                                                          |             
      Necrosis, Multifocal                 |                                                                          |             
      Regeneration, Diffuse                |                   3                    3                    2            |             
      Regeneration, Focal                  |                                  2  4                                    |             
      Regeneration, Multifocal             |                                              3                 4  3      |             
      Thrombosis                           |                                                             X            |             
      Vacuolization Cytoplasmic, Multifocal|       2        2                                2  2        2            |             
      Bile Duct, Hyperplasia               |                                                             2            |             
      Caudate Lobe, Pigmentation           |                                                                          |             
      Caudate Lobe, Regeneration           |                                                                          |             
      Centrilobular, Degeneration, Diffuse |       1                          3              1                       1|             
      Centrilobular, Necrosis, Diffuse     |                               2        3                                 |             
      Centrilobular, Necrosis              |                   1                 3                                    |             
      Periportal, Fibrosis                 |                                                                          |             
                                            __________________________________________________________________________|             
   Mesentery                               |    +  +           +                          +     +           +     +   |             
      Ectasia, Focal                       |                                              4                           |             
      Fat, Necrosis                        |    3              3                                3           3     3   |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  81                                                               
NTP Experiment-Test: 05172-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                               3,3-DIMETHOXYBENZIDINE DIHYDROCHLORIDE                          Date: 04/30/97  
Route: DOSED WATER                                                                                                Time: 17:38:14  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 5| 4| 4| 4| 5| 5| 5| 4| 4| 6| 5| 5| 5| 4| 5| 5| 5| 5| 2| 6| 5| 5| 4| 4|             
                             DAY ON TEST   | 1| 6| 8| 8| 0| 6| 7| 4| 6| 2| 0| 5| 4| 2| 8| 6| 6| 6| 5| 8| 1| 6| 3| 8| 8|             
                                           | 6| 1| 3| 3| 8| 2| 8| 6| 7| 4| 4| 3| 6| 6| 5| 1| 1| 1| 6| 4| 6| 0| 8| 6| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
    170 PPM                                | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
                                           |                                                                          |             
      Vein, Ectasia                        |                                                                          |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              | 2        1     2                                                         |             
                                            __________________________________________________________________________|             
   Pharynx                                 |             +  +                                                         |             
      Palate, Hyperplasia, Focal, Squamous |                                                                          |             
      Palate, Hyperplasia, Squamous        |                                                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Acanthosis                           |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Erosion, Focal                       |                   1                                                      |             
      Erosion, Multifocal                  |                      2                                            2      |             
      Hemorrhage, Multifocal               |                                     3                                    |             
      Mineralization                       |                                        3                                 |             
                                            __________________________________________________________________________|             
   Tongue                                  |                                                                   +      |             
      Necrosis, Focal                      |                                                                   1      |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cardiomyopathy, Chronic              | 2  2  1  2  2  2  1  2  2  2  2  2     2  1        2  2  2  2  1     3  1|             
      Inflammation, Acute, Multifocal      |                                                                          |             
      Atrium, Thrombosis                   | X  X           X  X           X     X        X  X  X        X            |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                                                                          |             
      Hyperplasia, Focal                   |                                                                          |             
      Necrosis, Multifocal                 |                                                                          |             
      Pigmentation                         |                                                                          |             
      Vacuolization Cytoplasmic, Diffuse   |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                                                                          |             
      Hyperplasia, Focal                   |                   1           2        2                             2   |             
      Hyperplasia, Multifocal              |                                                                          |             
      Pigmentation                         |                                                                          |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Focal                   |                                                                          |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                        3           2                     |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Pars Distalis, Angiectasis           |                                                                          |             
      Pars Distalis, Congestion            |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  82                                                               
NTP Experiment-Test: 05172-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                               3,3-DIMETHOXYBENZIDINE DIHYDROCHLORIDE                          Date: 04/30/97  
Route: DOSED WATER                                                                                                Time: 17:38:14  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 5| 4| 4| 4| 5| 5| 5| 4| 4| 6| 5| 5| 5| 4| 5| 5| 5| 5| 2| 6| 5| 5| 4| 4|             
                             DAY ON TEST   | 1| 6| 8| 8| 0| 6| 7| 4| 6| 2| 0| 5| 4| 2| 8| 6| 6| 6| 5| 8| 1| 6| 3| 8| 8|             
                                           | 6| 1| 3| 3| 8| 2| 8| 6| 7| 4| 4| 3| 6| 6| 5| 1| 1| 1| 6| 4| 6| 0| 8| 6| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
    170 PPM                                | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
      Pars Distalis, Cyst                  |                                                                          |             
      Pars Distalis, Hyperplasia, Focal    |                                                                          |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      C-Cell, Hyperplasia, Focal           |    2                                               1                     |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Tissue NOS                              |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atypia Cellular                      |                                                                          |             
                                            __________________________________________________________________________|             
   Preputial Gland                         | +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                   3              3           3                 3         |             
      Cyst                                 |                                                                   4      |             
      Ectasia                              | 3        3        4        3  3           2                              |             
      Hyperplasia, Focal                   |    2                                                     2               |             
      Hyperplasia, Focal, Squamous         |                   1                                                      |             
      Hyperplasia, Multifocal, Squamous    |                                                                          |             
      Inflammation, Acute                  |                                                                          |             
      Inflammation, Chronic                |                                  3                                       |             
      Inflammation, Chronic Active         |       2                                   2                              |             
                                            __________________________________________________________________________|             
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Focal, Glandular        |                                                                          |             
      Hyperplasia, Glandular, Multifocal   |                                                                          |             
      Inflammation, Acute                  |                                                                          |             
      Inflammation, Chronic                |                                                                          |             
      Inflammation, Chronic Active         |                                  3        2  4              3            |             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         | +  +  +  +  M  +  +  +  M  M  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +|             
      Atrophy                              |                                                                         2|             
      Inflammation, Chronic Active         |                                                                          |             
      Epithelium, Hyperplasia, Focal       |                                                                          |             
                                            __________________________________________________________________________|             
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                                                                          |             
      Cyst                                 |                                                                          |             
      Degeneration                         |                                                                          |             
      Interstitial Cell, Hyperplasia       |       2  2  2              2        2                    1               |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          | 3  3           3                       3           3        3            |             
      Hypoplasia                           |                                                                          |             
      Myelofibrosis, Focal                 |                                     3  1                                 |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Axillary, Hemorrhage                 |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  83                                                               
NTP Experiment-Test: 05172-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                               3,3-DIMETHOXYBENZIDINE DIHYDROCHLORIDE                          Date: 04/30/97  
Route: DOSED WATER                                                                                                Time: 17:38:14  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 5| 4| 4| 4| 5| 5| 5| 4| 4| 6| 5| 5| 5| 4| 5| 5| 5| 5| 2| 6| 5| 5| 4| 4|             
                             DAY ON TEST   | 1| 6| 8| 8| 0| 6| 7| 4| 6| 2| 0| 5| 4| 2| 8| 6| 6| 6| 5| 8| 1| 6| 3| 8| 8|             
                                           | 6| 1| 3| 3| 8| 2| 8| 6| 7| 4| 4| 3| 6| 6| 5| 1| 1| 1| 6| 4| 6| 0| 8| 6| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
    170 PPM                                | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Axillary, Hyperplasia, Lymphoid      |                                                             3            |             
      Iliac, Hyperplasia, Lymphoid         |                                                                          |             
      Inguinal, Necrosis                   |                                     4                                    |             
      Mediastinal, Atrophy                 |                                                                          |             
      Mediastinal, Congestion              |                               3     4                                    |             
      Mediastinal, Hemorrhage              |                                        2                                 |             
      Mediastinal, Hyperplasia, Lymphoid   |                               3                                          |             
      Mediastinal, Pigmentation            |       3                                                                  |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +|             
      Congestion                           |                               3                                          |             
      Hyperplasia, Lymphoid                |                               3                                          |             
      Hyperplasia, Reticulum Cell          |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Lymphoid                |                                           3                              |             
      Hyperplasia, Reticulum Cell          |                                                          1               |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                         3                                                |             
      Hematopoietic Cell Proliferation     |    3  3     2  3  4        4  3  4     3  2  3  4  4  2     3        3   |             
      Hyperplasia, Reticulum Cell          |                                                                          |             
      Necrosis                             |                                                                          |             
      Pigmentation, Hemosiderin            |                         3                                                |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  M  +  +  M  +  M  +  +  +  M  M  +  +  +  +  +  +  +  +  +  +  M  M|             
      Atrophy                              |                                                                          |             
      Edema                                |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  M  +  +  +|             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Abscess                              |                                                                          |             
      Acanthosis, Focal                    |                                                                          |             
      Cyst Epithelial Inclusion            |                                                                          |             
      Granuloma, Focal                     |                                                                          |             
      Hyperkeratosis, Focal                |                                                                          |             
      Dermis, Fibrosis, Focal              |                   3                                                      |             
      Hair Follicle, Hyperplasia, Basal    |                                                                          |             
          Cell, Focal                      |                                                    3                     |             
      Subcutaneous Tissue, Edema           |                               4                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    |                                                                          |             
      Cranium, Proliferation, Focal        |                                                                          |             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |                                  +                                       |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  84                                                               
NTP Experiment-Test: 05172-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                               3,3-DIMETHOXYBENZIDINE DIHYDROCHLORIDE                          Date: 04/30/97  
Route: DOSED WATER                                                                                                Time: 17:38:14  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 5| 4| 4| 4| 5| 5| 5| 4| 4| 6| 5| 5| 5| 4| 5| 5| 5| 5| 2| 6| 5| 5| 4| 4|             
                             DAY ON TEST   | 1| 6| 8| 8| 0| 6| 7| 4| 6| 2| 0| 5| 4| 2| 8| 6| 6| 6| 5| 8| 1| 6| 3| 8| 8|             
                                           | 6| 1| 3| 3| 8| 2| 8| 6| 7| 4| 4| 3| 6| 6| 5| 1| 1| 1| 6| 4| 6| 0| 8| 6| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
    170 PPM                                | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cerebrum, Hemorrhage                 |                                                                          |             
      Cerebrum, Thrombosis, Multifocal     |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Congestion                           |                                                                          |             
      Edema                                |                                                                          |             
      Hemorrhage                           |                                                                          |             
      Hyperplasia, Lymphoid                |    3  2  3  2  2  2        2  2        2  2     2  2  3  2           2  1|             
      Infiltration Cellular, Histiocyte    | 2                                      2                                 |             
      Pigmentation, Focal                  |                                                                          |             
      Alveolar Epithelium, Hyperplasia,    |                                                                          |             
           Focal                           |                2     1                                                   |             
      Alveolar Epithelium, Hyperplasia,    |                                                                          |             
           Multifocal                      |                                                 2                        |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fungus                               |          3  2                                                            |             
      Hyperkeratosis                       |                                                                          |             
      Inflammation, Acute                  |             3                                3                           |             
      Inflammation, Chronic                |          2                                                               |             
      Necrosis, Focal                      |                                                                          |             
      Necrosis, Multifocal                 |                                                                          |             
      Mucosa, Hyperplasia                  |             2                                                            |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                                                             +            |             
      Cataract                             |                                                             3            |             
      Retina, Degeneration                 |                                                             4            |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                                                                          |             
                                            __________________________________________________________________________|             
   Zymbal's Gland                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Ectasia, Focal                       |                                                                          |             
      Ectasia                              | 2     3     1  3  2  2  1  1  1  4  3  2  2  2           2        3  2   |             
      Hyperplasia, Focal                   |                                        1                                 |             
      Hyperplasia, Focal, Squamous         |                3                                                         |             
      Hyperplasia, Squamous                |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hydronephrosis                       |                                                                          |             
      Nephropathy, Chronic                 | 3  3  2  2  2  2  1  1     1  2           2  2  2  2  2  2  1  2  1  3  1|             
      Thrombosis, Multifocal               |                                     3                                    |             
      Cortex, Infarct, Acute               |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  85                                                               
NTP Experiment-Test: 05172-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                               3,3-DIMETHOXYBENZIDINE DIHYDROCHLORIDE                          Date: 04/30/97  
Route: DOSED WATER                                                                                                Time: 17:38:14  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 5| 4| 4| 4| 5| 5| 5| 4| 4| 6| 5| 5| 5| 4| 5| 5| 5| 5| 2| 6| 5| 5| 4| 4|             
                             DAY ON TEST   | 1| 6| 8| 8| 0| 6| 7| 4| 6| 2| 0| 5| 4| 2| 8| 6| 6| 6| 5| 8| 1| 6| 3| 8| 8|             
                                           | 6| 1| 3| 3| 8| 2| 8| 6| 7| 4| 4| 3| 6| 6| 5| 1| 1| 1| 6| 4| 6| 0| 8| 6| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
    170 PPM                                | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
      Proximal Convoluted Renal Tubule,    |                                                                          |             
           Necrosis, Diffuse               |                                                                          |             
      Renal Tubule, Mineralization         |                                        4                                 |             
      Renal Tubule, Pigmentation           |                                                                          |             
      Transitional Epithelium, Hyperplasia,|                                                                          |             
           Focal                           |                                                                          |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |                                                                          |             
      Inflammation, Acute                  |                                                                          |             
      Necrosis, Diffuse                    |                                                                          |             
      Necrosis, Focal                      |                                                                          |             
      Mucosa, Hyperplasia                  |                                                                          |             
      Serosa, Cyst                         |                         3                                                |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  86                                                               
NTP Experiment-Test: 05172-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                               3,3-DIMETHOXYBENZIDINE DIHYDROCHLORIDE                          Date: 04/30/97  
Route: DOSED WATER                                                                                                Time: 17:38:14  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 6| 5| 5| 4| 5| 5| 5| 4| 4| 6| 5| 5| 4| 3| 6| 5| 5| 5| 4| 5| 5| 4| 4| 3|            |
                             DAY ON TEST   | 3| 0| 5| 4| 3| 5| 3| 0| 8| 7| 4| 9| 1| 2| 3| 1| 6| 5| 0| 8| 8| 3| 8| 5| 5|            |
                                           | 2| 3| 7| 6| 7| 6| 5| 8| 3| 2| 4| 6| 4| 4| 3| 6| 2| 6| 6| 5| 1| 3| 5| 8| 8|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|      A     |
    170 PPM                                | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  75        |
                                            __________________________________________________________________________|____________|
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  73        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  72        |
      Congestion                           |                                                                3         |      1  3.0|
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  73        |
      Parasite Metazoan                    |                                                                          |      2     |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  73        |
      Parasite Metazoan                    |                                                                          |      4  1.0|
                                            __________________________________________________________________________|____________|
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  70        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  70        |
      Mucosa, Hyperplasia, Diffuse         |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  69        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  69        |
      Congestion                           |                                                                3         |      1  3.0|
      Mucosa, Hyperplasia, Focal           |                               3                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  74        |
      Basophilic Focus                     | 2  2  2  2  1     1  2     2  1  1  1     1  2  2  2     1               |     48  1.8|
      Clear Cell Focus                     |                2              2           2              1        1      |     16  1.9|
      Degeneration, Cystic, Focal          |          1                                   2                           |      4  1.8|
      Degeneration, Cystic                 |    1  1        2                 3              1  2  1        1  2      |     28  1.4|
      Degeneration, Cystic, Multifocal     |                                                                          |      2  2.0|
      Ectasia, Multifocal                  |                                                                          |      1  2.0|
      Eosinophilic Focus                   | 1  3  2  3     2              1              2  2  2     1           1   |     35  1.9|
      Fatty Change                         |                                     2                                    |      4  2.3|
      Hematopoietic Cell Proliferation     | 2  2     2     2  3        1  2  1  2        1  2     2  2  1            |     39  1.6|
      Hepatodiaphragmatic Nodule           |                                                          X               |      2     |
      Necrosis, Coagulative                |                                                                          |      1  3.0|
      Necrosis, Focal                      |                            2                                             |      2  1.5|
      Necrosis, Multifocal                 |                                     2                       2            |      5  2.2|
      Regeneration, Diffuse                |                                                       2                  |      8  2.8|
      Regeneration, Focal                  |                                                                          |      3  3.3|
      Regeneration, Multifocal             |                   3              3  3              3              4      |     11  3.2|
      Thrombosis                           |                                                                          |      3     |
      Vacuolization Cytoplasmic, Multifocal|                2              2                                          |      7  2.0|
      Bile Duct, Hyperplasia               |                                                       3                  |      6  2.5|
      Caudate Lobe, Pigmentation           |                                                                         3|      1  3.0|
      Caudate Lobe, Regeneration           |                                                                         2|      1  2.0|
      Centrilobular, Degeneration, Diffuse |                                                 2     3        2         |      9  2.0|
      Centrilobular, Necrosis, Diffuse     |                   2                 3                                    |      6  2.8|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  87                                                               
NTP Experiment-Test: 05172-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                               3,3-DIMETHOXYBENZIDINE DIHYDROCHLORIDE                          Date: 04/30/97  
Route: DOSED WATER                                                                                                Time: 17:38:14  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 6| 5| 5| 4| 5| 5| 5| 4| 4| 6| 5| 5| 4| 3| 6| 5| 5| 5| 4| 5| 5| 4| 4| 3|            |
                             DAY ON TEST   | 3| 0| 5| 4| 3| 5| 3| 0| 8| 7| 4| 9| 1| 2| 3| 1| 6| 5| 0| 8| 8| 3| 8| 5| 5|            |
                                           | 2| 3| 7| 6| 7| 6| 5| 8| 3| 2| 4| 6| 4| 4| 3| 6| 2| 6| 6| 5| 1| 3| 5| 8| 8|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|      A     |
    170 PPM                                | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
                                           |                                                                          |            |
      Centrilobular, Necrosis              |                                  1                                       |      4  2.3|
      Periportal, Fibrosis                 |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Mesentery                               |          +  +  +        +  +              +  +  +           +  +     +   |  28        |
      Ectasia, Focal                       |                                                                          |      1  4.0|
      Fat, Necrosis                        |          3              3  3              3  3  3           3        3   |     22  3.0|
      Vein, Ectasia                        |                                                                4         |      1  4.0|
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  75        |
      Atrophy                              |                                                             2            |      5  1.8|
                                            __________________________________________________________________________|____________|
   Pharynx                                 | +  +     +                                                     +     +   |   7        |
      Palate, Hyperplasia, Focal, Squamous |          2                                                               |      1  2.0|
      Palate, Hyperplasia, Squamous        |    2                                                                     |      1  2.0|
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  75        |
                                            __________________________________________________________________________|____________|
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  73        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  73        |
      Acanthosis                           |                                                       3                  |      2  2.5|
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  72        |
      Erosion, Focal                       |                                                                          |      2  1.5|
      Erosion, Multifocal                  |                   2                                                      |      4  2.3|
      Hemorrhage, Multifocal               |                                                                          |      1  3.0|
      Mineralization                       |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Tongue                                  |          +                       +        +  +                           |   6        |
      Necrosis, Focal                      |                                                                          |      1  1.0|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  75        |
      Cardiomyopathy, Chronic              | 2  2  2  2  1     2     2  1     1  2  2  2  2  2  2     2  3     2  2  1|     58  1.9|
      Inflammation, Acute, Multifocal      |                                                       2                  |      1  2.0|
      Atrium, Thrombosis                   | X  X     X        X           X  X  X           X     X           X      |     27     |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  74        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  74        |
      Atrophy                              |                                                                          |      1  4.0|
      Hyperplasia, Focal                   |                                                                         1|      1  1.0|
      Necrosis, Multifocal                 |                                                             4            |      1  4.0|
      Pigmentation                         |                                                                          |      1  4.0|
      Vacuolization Cytoplasmic, Diffuse   |                                                       3                  |      1  3.0|
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  74        |
      Atrophy                              |                                                                          |      1  4.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  88                                                               
NTP Experiment-Test: 05172-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                               3,3-DIMETHOXYBENZIDINE DIHYDROCHLORIDE                          Date: 04/30/97  
Route: DOSED WATER                                                                                                Time: 17:38:14  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 6| 5| 5| 4| 5| 5| 5| 4| 4| 6| 5| 5| 4| 3| 6| 5| 5| 5| 4| 5| 5| 4| 4| 3|            |
                             DAY ON TEST   | 3| 0| 5| 4| 3| 5| 3| 0| 8| 7| 4| 9| 1| 2| 3| 1| 6| 5| 0| 8| 8| 3| 8| 5| 5|            |
                                           | 2| 3| 7| 6| 7| 6| 5| 8| 3| 2| 4| 6| 4| 4| 3| 6| 2| 6| 6| 5| 1| 3| 5| 8| 8|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|      A     |
    170 PPM                                | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
                                           |                                                                          |            |
      Hyperplasia, Focal                   |                   2                 1                                    |      8  1.8|
      Hyperplasia, Multifocal              |                                              2                           |      4  2.0|
      Pigmentation                         |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  75        |
      Hyperplasia, Focal                   |                         2                                   1            |      2  1.5|
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  74        |
      Hyperplasia                          |          2                                                               |      3  2.3|
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  74        |
      Pars Distalis, Angiectasis           |                2                                                         |      1  2.0|
      Pars Distalis, Congestion            |                                                                          |      1  2.0|
      Pars Distalis, Cyst                  |                                     3                                    |      1  3.0|
      Pars Distalis, Hyperplasia, Focal    |                      1                                                   |      1  1.0|
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  74        |
      C-Cell, Hyperplasia, Focal           |                                                                          |      2  1.5|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Tissue NOS                              |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  75        |
      Atypia Cellular                      |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Preputial Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  73        |
      Atrophy                              |                3                                3  3           3         |     10  3.0|
      Cyst                                 |                                                                          |      1  4.0|
      Ectasia                              |                      3  3     3  3  2           4  3        3        3   |     25  3.0|
      Hyperplasia, Focal                   |       2                 1                                                |      4  1.8|
      Hyperplasia, Focal, Squamous         | 3                                                                        |      5  1.4|
      Hyperplasia, Multifocal, Squamous    |                               3                                          |      1  3.0|
      Inflammation, Acute                  |                                                                          |      2  3.5|
      Inflammation, Chronic                |                                                                          |      1  3.0|
      Inflammation, Chronic Active         |                                                                          |      2  2.0|
                                            __________________________________________________________________________|____________|
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  75        |
      Hyperplasia, Focal, Glandular        |                                              2                           |      2  2.0|
      Hyperplasia, Glandular, Multifocal   |                               2                                          |      3  2.0|
      Inflammation, Acute                  |                                                                          |      2  2.5|
      Inflammation, Chronic                |                                                                          |      1  2.0|
      Inflammation, Chronic Active         |                                                       3           3     3|     11  3.2|
                                            __________________________________________________________________________|____________|
   Seminal Vesicle                         | +  +  +  +  M  +  +  +  +  +  +  +  +  M  M  +  +  +  +  +  +  +  +  M  M|  58        |
      Atrophy                              |                                                                          |      1  2.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  89                                                               
NTP Experiment-Test: 05172-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                               3,3-DIMETHOXYBENZIDINE DIHYDROCHLORIDE                          Date: 04/30/97  
Route: DOSED WATER                                                                                                Time: 17:38:14  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 6| 5| 5| 4| 5| 5| 5| 4| 4| 6| 5| 5| 4| 3| 6| 5| 5| 5| 4| 5| 5| 4| 4| 3|            |
                             DAY ON TEST   | 3| 0| 5| 4| 3| 5| 3| 0| 8| 7| 4| 9| 1| 2| 3| 1| 6| 5| 0| 8| 8| 3| 8| 5| 5|            |
                                           | 2| 3| 7| 6| 7| 6| 5| 8| 3| 2| 4| 6| 4| 4| 3| 6| 2| 6| 6| 5| 1| 3| 5| 8| 8|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|      A     |
    170 PPM                                | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 GENITAL SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
      Inflammation, Chronic Active         |                                                                          |      1  4.0|
      Epithelium, Hyperplasia, Focal       |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  75        |
      Atrophy                              |                                                             4            |      2  3.0|
      Cyst                                 |                                     4                                    |      1  4.0|
      Degeneration                         |                                                                          |      1  3.0|
      Interstitial Cell, Hyperplasia       |                                     2           2           2           2|     14  1.9|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  74        |
      Hyperplasia                          |       3           3              2              3                        |     14  2.8|
      Hypoplasia                           |                                                                          |      1  2.0|
      Myelofibrosis, Focal                 |                                                                          |      2  2.0|
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  75        |
      Axillary, Hemorrhage                 |                                                       3                  |      1  3.0|
      Axillary, Hyperplasia, Lymphoid      |                                                                          |      1  3.0|
      Iliac, Hyperplasia, Lymphoid         |                                                                         3|      1  3.0|
      Inguinal, Necrosis                   |                                                                          |      1  4.0|
      Mediastinal, Atrophy                 |                                                                3         |      2  3.0|
      Mediastinal, Congestion              |                                                                          |      3  3.3|
      Mediastinal, Hemorrhage              |                                                       3                  |      2  2.5|
      Mediastinal, Hyperplasia, Lymphoid   | 3                                                                        |      2  3.0|
      Mediastinal, Pigmentation            |                                                                          |      2  3.5|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  74        |
      Congestion                           |                                        2                                 |      2  2.5|
      Hyperplasia, Lymphoid                |                                                                          |      1  3.0|
      Hyperplasia, Reticulum Cell          |                                        3                                 |      1  3.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  73        |
      Hyperplasia, Lymphoid                |                                                                          |      2  3.5|
      Hyperplasia, Reticulum Cell          |                   3                       2                              |      6  2.0|
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  74        |
      Atrophy                              |                                                             3        4   |      4  3.3|
      Hematopoietic Cell Proliferation     | 3  4     3     2  4        3  2  3  3        3  3     3  3  2  3        3|     43  3.0|
      Hyperplasia, Reticulum Cell          | 3                                   3                 3                  |      4  3.3|
      Necrosis                             |                                                                          |      1  3.0|
      Pigmentation, Hemosiderin            |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  M  +  M  M  +  +  M  M  +  +  +  +  +  +  +  M  +  M  +  +  M  +  +  +|  55        |
      Atrophy                              |                                                                          |      1  2.0|
      Edema                                |                                                                          |      1  4.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  90                                                               
NTP Experiment-Test: 05172-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                               3,3-DIMETHOXYBENZIDINE DIHYDROCHLORIDE                          Date: 04/30/97  
Route: DOSED WATER                                                                                                Time: 17:38:14  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 6| 5| 5| 4| 5| 5| 5| 4| 4| 6| 5| 5| 4| 3| 6| 5| 5| 5| 4| 5| 5| 4| 4| 3|            |
                             DAY ON TEST   | 3| 0| 5| 4| 3| 5| 3| 0| 8| 7| 4| 9| 1| 2| 3| 1| 6| 5| 0| 8| 8| 3| 8| 5| 5|            |
                                           | 2| 3| 7| 6| 7| 6| 5| 8| 3| 2| 4| 6| 4| 4| 3| 6| 2| 6| 6| 5| 1| 3| 5| 8| 8|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|      A     |
    170 PPM                                | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +  +  +  +  M  +  +  +  +  +  M  +  +  +  +  +  M  +  +  +  +  +  +|  68        |
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  75        |
      Abscess                              |                                                                          |      1  3.0|
      Acanthosis, Focal                    |                                  3                                       |      1  3.0|
      Cyst Epithelial Inclusion            |                                                                         2|      1  2.0|
      Granuloma, Focal                     |                                                                          |      1  4.0|
      Hyperkeratosis, Focal                |                                  4                          4            |      2  4.0|
      Dermis, Fibrosis, Focal              |                                                       2                  |      2  2.5|
      Hair Follicle, Hyperplasia, Basal    |                                                                          |            |
          Cell, Focal                      |                                                                          |      1  3.0|
      Subcutaneous Tissue, Edema           |                                                                          |      3  3.3|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    |                   +                                                      |   1        |
      Cranium, Proliferation, Focal        |                   2                                                      |      1  2.0|
                                            __________________________________________________________________________|____________|
   Skeletal Muscle                         |             +                                                            |   3        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  75        |
      Cerebrum, Hemorrhage                 |                                                                          |      2  1.5|
      Cerebrum, Thrombosis, Multifocal     |                                                       2                  |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  75        |
      Congestion                           |                                                                          |      1  3.0|
      Edema                                |                                                       3                  |      1  3.0|
      Hemorrhage                           |                                                                          |      1  1.0|
      Hyperplasia, Lymphoid                | 2  2  2  2  1  2  2     1  2  2  2     2  2  3  2  2     2  1     2     2|     55  2.0|
      Infiltration Cellular, Histiocyte    |                   2                                   3     3           2|     10  2.2|
      Pigmentation, Focal                  |                                                                          |      1  3.0|
      Alveolar Epithelium, Hyperplasia,    |                                                                          |            |
           Focal                           |                                                 1                        |      6  1.7|
      Alveolar Epithelium, Hyperplasia,    |                                                                          |            |
           Multifocal                      |                                                                          |      3  2.3|
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  74        |
      Fungus                               |    2                          3     4                       3            |      9  3.0|
      Hyperkeratosis                       |                                                             4            |      2  3.5|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  91                                                               
NTP Experiment-Test: 05172-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                               3,3-DIMETHOXYBENZIDINE DIHYDROCHLORIDE                          Date: 04/30/97  
Route: DOSED WATER                                                                                                Time: 17:38:14  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 6| 5| 5| 4| 5| 5| 5| 4| 4| 6| 5| 5| 4| 3| 6| 5| 5| 5| 4| 5| 5| 4| 4| 3|            |
                             DAY ON TEST   | 3| 0| 5| 4| 3| 5| 3| 0| 8| 7| 4| 9| 1| 2| 3| 1| 6| 5| 0| 8| 8| 3| 8| 5| 5|            |
                                           | 2| 3| 7| 6| 7| 6| 5| 8| 3| 2| 4| 6| 4| 4| 3| 6| 2| 6| 6| 5| 1| 3| 5| 8| 8|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|      A     |
    170 PPM                                | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 RESPIRATORY SYSTEM - cont                 |                                                                          |            |
                                           |                                                                          |            |
      Inflammation, Acute                  |    3                          3                             3            |      8  3.0|
      Inflammation, Chronic                |                                     4                                    |      2  3.0|
      Necrosis, Focal                      |    2                                4                                    |      2  3.0|
      Necrosis, Multifocal                 |                               3                                          |      1  3.0|
      Mucosa, Hyperplasia                  |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  75        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Eye                                     |                                                 +  M                     |   3        |
      Cataract                             |                                                                          |      2  3.0|
      Retina, Degeneration                 |                                                 3                        |      3  3.7|
                                            __________________________________________________________________________|____________|
   Harderian Gland                         |                                                                          |   1        |
                                            __________________________________________________________________________|____________|
   Zymbal's Gland                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  75        |
      Ectasia, Focal                       |                                                                          |      1  2.0|
      Ectasia                              | 3     3  2  2  2  3     3  2  2  2  4        2  3     3     3  2  2  3   |     53  2.2|
      Hyperplasia, Focal                   |                                                                          |      2  1.0|
      Hyperplasia, Focal, Squamous         |                      1     1  2  1        1  1           1     1         |     10  1.4|
      Hyperplasia, Squamous                |                                                                          |      1  1.0|
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  74        |
      Hydronephrosis                       |                                                                          |      1  3.0|
      Nephropathy, Chronic                 | 3  2  3  1  2  2  1     2     2  2     2  2  2  1  2        3  1  2     2|     58  2.0|
      Thrombosis, Multifocal               |                                                       X                  |      2  3.0|
      Cortex, Infarct, Acute               |                                                                   3      |      1  3.0|
      Proximal Convoluted Renal Tubule,    |                                                                          |            |
           Necrosis, Diffuse               |                                                             4            |      1  4.0|
      Renal Tubule, Mineralization         |                                                             3            |      2  3.5|
      Renal Tubule, Pigmentation           |                3                                                         |      2  3.0|
      Transitional Epithelium, Hyperplasia,|                                                                          |            |
           Focal                           |                                  2                                       |      1  2.0|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  75        |
      Hemorrhage                           |             3                                                            |      3  3.7|
      Inflammation, Acute                  |                                                                          |      3  4.0|
      Necrosis, Diffuse                    |                                                                          |      2  4.0|
      Necrosis, Focal                      |                                                                          |      1  3.0|
      Mucosa, Hyperplasia                  |             3                                                            |      2  3.5|
      Serosa, Cyst                         |                                                                          |      1  3.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  92                                                               
NTP Experiment-Test: 05172-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                               3,3-DIMETHOXYBENZIDINE DIHYDROCHLORIDE                          Date: 04/30/97  
Route: DOSED WATER                                                                                                Time: 17:38:14  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 4| 4| 4| 4| 2| 5| 4| 4| 4| 3| 5| 5| 4| 4| 4|             
                             DAY ON TEST   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 9| 8| 2| 0| 7| 3| 8| 7| 4| 4| 9| 5| 8| 8| 2|             
                                           | 5| 5| 5| 5| 5| 5| 5| 5| 5| 7| 0| 6| 3| 1| 5| 7| 5| 8| 1| 4| 5| 0| 6| 3| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|             
    330 PPM                                | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               |                            +  +  +  +  +     +  +  +  +  +  +  +  +  +  +|             
      Hyperkeratosis                       |                                                                          |             
      Inflammation, Acute                  |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large                         |                            +  +  +  +  +     +  +  A  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  |                            +  +  +  +  +     +  +  M  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  |                            +  +  +  +  +     +  +  A  +  +  +  +  +  +  +|             
      Parasite Metazoan                    |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 |                            +  +  +  +  +     +  +  A  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small                         |                            +  +  +  +  +     +  +  A  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               |                            +  +  +  +  +     M  +  A  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  |                            +  +  +  +  +     +  +  M  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                |                            +  +  +  +  +     +  +  M  +  +  +  +  +  +  +|             
      Necrosis, Focal                      |                                                                          |             
                                            __________________________________________________________________________|             
   Liver                                   |                            +  +  +  +  +     +  +  +  +  +  +  +  +  +  +|             
      Basophilic Focus                     |                               2  1  2  1     2  2  2  1  2  2  3  2  3  2|             
      Clear Cell Focus                     |                                  2           1  2              2  2      |             
      Degeneration, Cystic, Focal          |                                                                3         |             
      Degeneration, Cystic                 |                               1                    1                     |             
      Degeneration, Cystic, Multifocal     |                                              4              2            |             
      Eosinophilic Focus                   |                                  2     2           2     1  3  4  3  2  2|             
      Fatty Change                         |                                                                          |             
      Granuloma                            |                                                                          |             
      Hematopoietic Cell Proliferation     |                            1  2  2     1     1  2  1  1     2  2  2  2  2|             
      Hepatodiaphragmatic Nodule           |                                                                          |             
      Necrosis, Coagulative                |                                                                          |             
      Necrosis, Focal                      |                            3                          1                  |             
      Necrosis, Multifocal                 |                               3                    3                     |             
      Regeneration, Diffuse                |                                                                          |             
      Regeneration, Focal                  |                                              4                           |             
      Regeneration, Multifocal             |                               3                    4                     |             
      Thrombosis                           |                                                                          |             
      Vacuolization Cytoplasmic, Focal     |                                     2           2                        |             
      Vacuolization Cytoplasmic, Multifocal|                                                                          |             
      Bile Duct, Hyperplasia               |                                                                3         |             
      Centrilobular, Degeneration, Diffuse |                               4                                         1|             
      Centrilobular, Necrosis, Diffuse     |                                        3     4                           |             
      Centrilobular, Necrosis              |                                                                          |             
      Periportal, Fibrosis                 |                                                                          |             
      Serosa, Inflammation, Acute          |                                                                          |             
                                            __________________________________________________________________________|             
   Mesentery                               |                                        +        +                 +      |             
      Inflammation, Acute                  |                                                                          |             
      Fat, Necrosis                        |                                                 3                 3      |             
                                            __________________________________________________________________________|             
   Pancreas                                |                            +  +  +  +  +     +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                                     1                                    |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  93                                                               
NTP Experiment-Test: 05172-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                               3,3-DIMETHOXYBENZIDINE DIHYDROCHLORIDE                          Date: 04/30/97  
Route: DOSED WATER                                                                                                Time: 17:38:14  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 4| 4| 4| 4| 2| 5| 4| 4| 4| 3| 5| 5| 4| 4| 4|             
                             DAY ON TEST   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 9| 8| 2| 0| 7| 3| 8| 7| 4| 4| 9| 5| 8| 8| 2|             
                                           | 5| 5| 5| 5| 5| 5| 5| 5| 5| 7| 0| 6| 3| 1| 5| 7| 5| 8| 1| 4| 5| 0| 6| 3| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|             
    330 PPM                                | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
                                           |                                                                          |             
      Degeneration                         |                                                                          |             
                                            __________________________________________________________________________|             
   Pharynx                                 |                                                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         |                            +  +  +  +  +     +  +  +  +  +  +  +  +  +  +|             
      Interlobular, Edema                  |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach                                 |                            +  +  +  +  +     +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    |                            +  +  +  +  +     +  +  +  +  +  +  +  +  +  +|             
      Acanthosis, Diffuse                  |                                                             2            |             
      Acanthosis                           |                                     3        3                           |             
      Ulcer                                |                                     3                                    |             
      Ulcer, Multifocal                    |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      |                            +  +  +  +  +     +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage, Focal                    |                                                                          |             
      Necrosis, Focal                      |                                                                          |             
                                            __________________________________________________________________________|             
   Tongue                                  |                                  +                                       |             
      Hyperkeratosis, Focal                |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   |                            +  +  +  +  +     +  +  +  +  +  +  +  +  +  +|             
      Cardiomyopathy, Chronic              |                            1     2     2     3     2  1  2  1     2      |             
      Inflammation, Acute, Multifocal      |                                                                          |             
      Atrium, Thrombosis                   |                            X     X           X              X  X  3      |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           |                            +  +  +  +  +     +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   |                            +  +  +  +  +     +  +  +  +  +  +  +  +  +  +|             
      Angiectasis, Multifocal              |                                                                          |             
      Infarct, Chronic                     |                                  4                                       |             
      Vacuolization Cytoplasmic, Diffuse   |                            2                                             |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  |                            +  +  +  +  +     +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Focal                   |                                                    2  2                  |             
      Hyperplasia, Multifocal              |                                                                          |             
      Infarct, Chronic                     |                                  4                                       |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      |                            +  +  +  +  +     +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       |                            +  +  +  +  +     +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         |                            +  +  +  +  +     +  +  +  +  +  +  +  +  +  +|             
      Pars Distalis, Cyst                  |                                                                2         |             
      Pars Intermedia, Cyst                |                                        2                                 |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           |                            +  +  +  +  +     +  +  +  +  +  +  +  +  +  +|             
      C-Cell, Hyperplasia, Focal           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  94                                                               
NTP Experiment-Test: 05172-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                               3,3-DIMETHOXYBENZIDINE DIHYDROCHLORIDE                          Date: 04/30/97  
Route: DOSED WATER                                                                                                Time: 17:38:14  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 4| 4| 4| 4| 2| 5| 4| 4| 4| 3| 5| 5| 4| 4| 4|             
                             DAY ON TEST   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 9| 8| 2| 0| 7| 3| 8| 7| 4| 4| 9| 5| 8| 8| 2|             
                                           | 5| 5| 5| 5| 5| 5| 5| 5| 5| 7| 0| 6| 3| 1| 5| 7| 5| 8| 1| 4| 5| 0| 6| 3| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|             
    330 PPM                                | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              |                            +  +  +  +  +     +  +  M  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Preputial Gland                         |                            +  +  +  +  +     +  +  M  +  +  +  +  +  +  +|             
      Atrophy                              |                            3                                             |             
      Ectasia                              |                               3  3  2  2     4  3     4     3     3      |             
      Hyperplasia, Focal                   |                                     2                             1      |             
      Hyperplasia, Focal, Squamous         |                               1                                          |             
      Inflammation, Acute                  |                                                                4         |             
      Inflammation, Chronic                |                                  2                                       |             
                                            __________________________________________________________________________|             
   Prostate                                |                            +  +  +  +  +     +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Focal, Glandular        |                                                 1                        |             
      Inflammation, Chronic Active         |                            2        1                 1           3      |             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         |                            M  +  +  M  M     +  +  +  M  +  +  +  +  +  +|             
      Atrophy                              |                                  3                                       |             
                                            __________________________________________________________________________|             
   Testes                                  |                            +  +  +  +  +     +  +  M  +  +  +  +  +  +  +|             
      Atrophy                              |                                                                          |             
      Degeneration                         |                            1           3                                 |             
      Interstitial Cell, Hyperplasia       |                                  1                                       |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood                                   |                                                       +                  |             
                                            __________________________________________________________________________|             
   Bone Marrow                             |                            +  +  +  +  +     +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                                                          |             
      Myelofibrosis, Focal                 |                                     2                                    |             
      Myelofibrosis                        |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node                              |                            +  +  +  +  +     +  +  +  +  +  +  +  +  +  +|             
      Bronchial, Congestion                |                                                                          |             
      Inguinal, Hyperplasia, Lymphoid      |                                                                          |             
      Mediastinal, Congestion              |                                                                          |             
      Mediastinal, Hyperplasia, Lymphoid   |                                                                          |             
      Mediastinal, Pigmentation            |                                        3                                 |             
      Pancreatic, Congestion               |                                                                          |             
      Pancreatic, Hyperplasia, Reticulum   |                                                                          |             
          Cell                             |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  |                            +  +  +  +  +     +  +  +  +  +  +  +  +  +  +|             
      Congestion                           |                                                                          |             
      Hyperplasia, Lymphoid                |                                                          2               |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  |                            +  +  +  +  +     +  +  M  +  +  +  +  +  +  +|             
      Congestion                           |                                                                          |             
      Hyperplasia, Lymphoid                |                                  3                                       |             
      Hyperplasia, Reticulum Cell          |                                                          2  3  2         |             
                                            __________________________________________________________________________|             
   Spleen                                  |                            +  +  +  +  +     +  +  +  +  +  +  +  +  +  +|             
      Angiectasis, Focal                   |                                                                          |             
      Atrophy                              |                                                                          |             
      Hematopoietic Cell Proliferation     |                            3  4  4     3     3  3  4        3     3  3  3|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  95                                                               
NTP Experiment-Test: 05172-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                               3,3-DIMETHOXYBENZIDINE DIHYDROCHLORIDE                          Date: 04/30/97  
Route: DOSED WATER                                                                                                Time: 17:38:14  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 4| 4| 4| 4| 2| 5| 4| 4| 4| 3| 5| 5| 4| 4| 4|             
                             DAY ON TEST   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 9| 8| 2| 0| 7| 3| 8| 7| 4| 4| 9| 5| 8| 8| 2|             
                                           | 5| 5| 5| 5| 5| 5| 5| 5| 5| 7| 0| 6| 3| 1| 5| 7| 5| 8| 1| 4| 5| 0| 6| 3| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|             
    330 PPM                                | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Hyperplasia, Megakaryocyte           |                                  3                                       |             
      Hyperplasia, Reticulum Cell          |                               3                                          |             
      Metaplasia                           |                                                                          |             
      Necrosis, Multifocal                 |                                                                          |             
                                            __________________________________________________________________________|             
   Thymus                                  |                            +  +  +  M  +     +  M  +  M  +  +  +  M  +  +|             
      Hemorrhage                           |                               4                                          |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           |                            +  +  +  +  +     +  +  M  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Skin                                    |                            +  +  +  +  +     +  +  +  +  +  +  +  +  +  +|             
      Acanthosis, Focal                    |                                                                   4      |             
      Dermis, Fibrosis, Focal              |                                  3                                       |             
      Dermis, Fibrosis                     |                                                                          |             
      Hair Follicle, Hyperplasia, Basal    |                                                                          |             
          Cell, Focal                      |                                                                          |             
      Prepuce, Hemorrhage                  |                                                                          |             
      Subcutaneous Tissue, Edema           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    |                                                       +                  |             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |                                                       +                  |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   |                            +  +  +  +  +     +  +  +  +  +  +  +  +  +  +|             
      Cerebellum, Hemorrhage               |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    |                            +  +  +  +  +     +  +  +  +  +  +  +  +  +  +|             
      Congestion                           |                                                                          |             
      Foreign Body                         |                                                                          |             
      Hemorrhage                           |                                                                          |             
      Hyperplasia, Lymphoid                |                            2  2  2  2  2     2  2  3     2  2  3  2  2  2|             
      Infiltration Cellular, Histiocyte    |                                  2                                       |             
      Inflammation, Acute, Multifocal      |                                                                          |             
      Thrombosis                           |                                                                          |             
      Thrombosis, Multiple                 |                                                                         X|             
      Alveolar Epithelium, Hyperplasia,    |                                                                          |             
           Focal                           |                               2                                          |             
      Alveolar Epithelium, Hyperplasia,    |                                                                          |             
           Multifocal                      |                                                                          |             
      Mediastinum, Inflammation, Acute     |                                                                          |             
                                            __________________________________________________________________________|             
   Nose                                    |                            +  +  +  +  +     +  +  +  +  +  +  +  +  +  +|             
      Foreign Body                         |                                                                          |             
      Fungus                               |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  96                                                               
NTP Experiment-Test: 05172-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                               3,3-DIMETHOXYBENZIDINE DIHYDROCHLORIDE                          Date: 04/30/97  
Route: DOSED WATER                                                                                                Time: 17:38:14  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 4| 4| 4| 4| 2| 5| 4| 4| 4| 3| 5| 5| 4| 4| 4|             
                             DAY ON TEST   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 9| 8| 2| 0| 7| 3| 8| 7| 4| 4| 9| 5| 8| 8| 2|             
                                           | 5| 5| 5| 5| 5| 5| 5| 5| 5| 7| 0| 6| 3| 1| 5| 7| 5| 8| 1| 4| 5| 0| 6| 3| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|             
    330 PPM                                | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
      Hyperkeratosis                       |                                                                          |             
      Inflammation, Acute                  |                                                             2            |             
      Inflammation, Chronic                |                                        3                                 |             
      Necrosis, Focal                      |                                        3                                 |             
      Glands, Hyperplasia                  |                                                                          |             
      Nasolacrimal Duct, Inflammation,     |                                                                          |             
           Acute                           |                                                                          |             
      Submucosa, Fibrosis                  |                                        3                                 |             
                                            __________________________________________________________________________|             
   Trachea                                 |                            +  +  +  +  +     +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ear                                     |                                                                          |             
      Canal, Hyperplasia, Focal, Squamous  |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                                     +                                    |             
      Cornea, Inflammation, Chronic        |                                     2                                    |             
                                            __________________________________________________________________________|             
   Zymbal's Gland                          |                            +  +  +  +  +     +  +  +  +  +  +  +  +  +  +|             
      Ectasia                              |                            2  3  2  2        3     3  3  2     3  3      |             
      Hyperplasia, Focal                   |                                                                          |             
      Hyperplasia, Focal, Squamous         |                                                 1  1     1        3      |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  |                            +  +  +  +  +     +  +  +  +  +  +  +  +  +  +|             
      Abscess, Multifocal                  |                                                                          |             
      Infarct, Acute                       |                                                                          |             
      Nephropathy, Chronic                 |                            2  2  2  3  2     2  2  2  2  2  2  2  1     2|             
      Renal Tubule, Necrosis, Focal        |                                                                          |             
      Renal Tubule, Pigmentation           |                                        3                                 |             
      Transitional Epithelium, Hyperplasia,|                                                                          |             
           Focal                           |                                                                          |             
                                            __________________________________________________________________________|             
   Urethra                                 |                                                                          |             
      Hyperplasia, Focal, Squamous         |                                                                          |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         |                            +  +  +  +  +     +  +  M  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  97                                                               
NTP Experiment-Test: 05172-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                               3,3-DIMETHOXYBENZIDINE DIHYDROCHLORIDE                          Date: 04/30/97  
Route: DOSED WATER                                                                                                Time: 17:38:14  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 5| 5| 5| 3| 5| 5| 5| 5| 4| 5| 5| 5| 5| 2| 5| 5| 5| 4| 4| 5| 5| 5| 5| 4|             
                             DAY ON TEST   | 9| 6| 4| 4| 3| 6| 6| 5| 5| 1| 9| 6| 4| 1| 8| 6| 5| 2| 8| 0| 6| 4| 3| 2| 4|             
                                           | 7| 0| 6| 2| 9| 0| 0| 0| 0| 9| 2| 0| 2| 1| 4| 0| 1| 5| 3| 2| 0| 6| 4| 7| 5|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|             
    330 PPM                                | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperkeratosis                       |                                                                          |             
      Inflammation, Acute                  |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +|             
      Parasite Metazoan                    |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +|             
      Necrosis, Focal                      |                                                                          |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Basophilic Focus                     |    1  3     1  3  2  3  2     3  1     3     1  1     2  1  2  2  1     2|             
      Clear Cell Focus                     | 2  2  1     1  2  2  2              2        2           1  2  3  2     2|             
      Degeneration, Cystic, Focal          | 3                                                                        |             
      Degeneration, Cystic                 |    1           1  1  2  1  2        2        1              3        2   |             
      Degeneration, Cystic, Multifocal     |                                  2     3                                 |             
      Eosinophilic Focus                   | 2        2     3  3     3     2  2  3  4  2  3  3  2        3  2        1|             
      Fatty Change                         |       2                                                                 2|             
      Granuloma                            |                                                          3               |             
      Hematopoietic Cell Proliferation     | 2     2     1  1  1  1  2     3     1     1  2  2     1        2  1     1|             
      Hepatodiaphragmatic Nodule           |                                                                          |             
      Necrosis, Coagulative                |                                                                          |             
      Necrosis, Focal                      |                                                          2               |             
      Necrosis, Multifocal                 |                      3              2                             2      |             
      Regeneration, Diffuse                |    3                                                              3      |             
      Regeneration, Focal                  | 2                                                                    4   |             
      Regeneration, Multifocal             |                   2  2  2     3        2                    4  4         |             
      Thrombosis                           |    X                                X                          3  X      |             
      Vacuolization Cytoplasmic, Focal     |                                                                          |             
      Vacuolization Cytoplasmic, Multifocal|    3  3        2                    2        2                    2      |             
      Bile Duct, Hyperplasia               |    4                                                                     |             
      Centrilobular, Degeneration, Diffuse | 2  3  2              3        3                                   3      |             
      Centrilobular, Necrosis, Diffuse     |                                                                          |             
      Centrilobular, Necrosis              |                                                                          |             
      Periportal, Fibrosis                 |    4                                                                     |             
      Serosa, Inflammation, Acute          |          3                                                               |             
                                            __________________________________________________________________________|             
   Mesentery                               |    +     +                                   +        +           +      |             
      Inflammation, Acute                  |          4                                                               |             
      Fat, Necrosis                        |    3                                         3        2           3      |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |       2                                                                  |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  98                                                               
NTP Experiment-Test: 05172-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                               3,3-DIMETHOXYBENZIDINE DIHYDROCHLORIDE                          Date: 04/30/97  
Route: DOSED WATER                                                                                                Time: 17:38:14  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 5| 5| 5| 3| 5| 5| 5| 5| 4| 5| 5| 5| 5| 2| 5| 5| 5| 4| 4| 5| 5| 5| 5| 4|             
                             DAY ON TEST   | 9| 6| 4| 4| 3| 6| 6| 5| 5| 1| 9| 6| 4| 1| 8| 6| 5| 2| 8| 0| 6| 4| 3| 2| 4|             
                                           | 7| 0| 6| 2| 9| 0| 0| 0| 0| 9| 2| 0| 2| 1| 4| 0| 1| 5| 3| 2| 0| 6| 4| 7| 5|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|             
    330 PPM                                | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
                                           |                                                                          |             
      Degeneration                         |                                                                          |             
                                            __________________________________________________________________________|             
   Pharynx                                 |                               +                    +        +            |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Interlobular, Edema                  |    3                                                                     |             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  A  +  +  +  +  +  +  +|             
      Acanthosis, Diffuse                  |                                                                          |             
      Acanthosis                           |                                                                          |             
      Ulcer                                |                                                                          |             
      Ulcer, Multifocal                    | 3                                                                        |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +|             
      Hemorrhage, Focal                    |                            1                                             |             
      Necrosis, Focal                      |                                                                          |             
                                            __________________________________________________________________________|             
   Tongue                                  | +                    +  +     +                       +  +               |             
      Hyperkeratosis, Focal                |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cardiomyopathy, Chronic              |       2  2  2  3  2  2  2  2     2  2     1     2  3     2  1  2  3  2  1|             
      Inflammation, Acute, Multifocal      |                               2                                          |             
      Atrium, Thrombosis                   | X  X           X  X  X        X     X           X           X  X  X  X   |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis, Multifocal              |                                                                      2   |             
      Infarct, Chronic                     |                                                                          |             
      Vacuolization Cytoplasmic, Diffuse   |          3                    2                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Focal                   |                               1                                          |             
      Hyperplasia, Multifocal              | 1                       2                                            2   |             
      Infarct, Chronic                     |                                                                          |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Pars Distalis, Cyst                  |                                                                          |             
      Pars Intermedia, Cyst                |                                                                          |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      C-Cell, Hyperplasia, Focal           |                                              1                           |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  99                                                               
NTP Experiment-Test: 05172-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                               3,3-DIMETHOXYBENZIDINE DIHYDROCHLORIDE                          Date: 04/30/97  
Route: DOSED WATER                                                                                                Time: 17:38:14  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 5| 5| 5| 3| 5| 5| 5| 5| 4| 5| 5| 5| 5| 2| 5| 5| 5| 4| 4| 5| 5| 5| 5| 4|             
                             DAY ON TEST   | 9| 6| 4| 4| 3| 6| 6| 5| 5| 1| 9| 6| 4| 1| 8| 6| 5| 2| 8| 0| 6| 4| 3| 2| 4|             
                                           | 7| 0| 6| 2| 9| 0| 0| 0| 0| 9| 2| 0| 2| 1| 4| 0| 1| 5| 3| 2| 0| 6| 4| 7| 5|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|             
    330 PPM                                | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Preputial Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                            3              2              3               |             
      Ectasia                              | 4  4  4                       3                          2  3     3      |             
      Hyperplasia, Focal                   |       2                                   1                              |             
      Hyperplasia, Focal, Squamous         |                2                                                         |             
      Inflammation, Acute                  |                                                                          |             
      Inflammation, Chronic                |                                                                          |             
                                            __________________________________________________________________________|             
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Focal, Glandular        |                                                                          |             
      Inflammation, Chronic Active         | 3        3                                            3        2         |             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         | +  +  +  +  M  +  +  +  +  M  +  +  +  +  M  +  +  +  +  +  +  +  +  +  M|             
      Atrophy                              |                                                                          |             
                                            __________________________________________________________________________|             
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |    4                                4                             4      |             
      Degeneration                         |                                                                          |             
      Interstitial Cell, Hyperplasia       |             2           2  2                    2     3           2  2   |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood                                   |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |          3              3           2           3  3                     |             
      Myelofibrosis, Focal                 |                   3                                                      |             
      Myelofibrosis                        |                      1                                                   |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +     +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +|             
      Bronchial, Congestion                |                                                                          |             
      Inguinal, Hyperplasia, Lymphoid      |                      3                                                   |             
      Mediastinal, Congestion              |                                                                          |             
      Mediastinal, Hyperplasia, Lymphoid   |                                                                      3   |             
      Mediastinal, Pigmentation            |                                                                          |             
      Pancreatic, Congestion               |                                                                          |             
      Pancreatic, Hyperplasia, Reticulum   |                                                                          |             
          Cell                             |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +     +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +|             
      Congestion                           |                                                                          |             
      Hyperplasia, Lymphoid                |                                           2        2  3                 3|             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +     +  +  +  +  +  A  +  +  +  +  +     +  +  +  +  +  +  +  +  +|             
      Congestion                           |                                                                          |             
      Hyperplasia, Lymphoid                |                                                                   3      |             
      Hyperplasia, Reticulum Cell          |                               4                                          |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +|             
      Angiectasis, Focal                   |                                              3                 3         |             
      Atrophy                              |    2     3                 4                                             |             
      Hematopoietic Cell Proliferation     | 4  3  4     2  4  3  3  3     4  3  3     2  3  3           3     3      |             
 _____________________________________________________________________________________________________________________|             
                                                             Page 100                                                               
NTP Experiment-Test: 05172-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                               3,3-DIMETHOXYBENZIDINE DIHYDROCHLORIDE                          Date: 04/30/97  
Route: DOSED WATER                                                                                                Time: 17:38:14  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 5| 5| 5| 3| 5| 5| 5| 5| 4| 5| 5| 5| 5| 2| 5| 5| 5| 4| 4| 5| 5| 5| 5| 4|             
                             DAY ON TEST   | 9| 6| 4| 4| 3| 6| 6| 5| 5| 1| 9| 6| 4| 1| 8| 6| 5| 2| 8| 0| 6| 4| 3| 2| 4|             
                                           | 7| 0| 6| 2| 9| 0| 0| 0| 0| 9| 2| 0| 2| 1| 4| 0| 1| 5| 3| 2| 0| 6| 4| 7| 5|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|             
    330 PPM                                | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Hyperplasia, Megakaryocyte           |                                                                          |             
      Hyperplasia, Reticulum Cell          |                         3                    3  4              3         |             
      Metaplasia                           |                                                 2                        |             
      Necrosis, Multifocal                 |       4                                                                  |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  +  +  M  M  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +|             
      Hemorrhage                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Acanthosis, Focal                    |                                                                          |             
      Dermis, Fibrosis, Focal              |                                                                          |             
      Dermis, Fibrosis                     |                                                                          |             
      Hair Follicle, Hyperplasia, Basal    |                                                                          |             
          Cell, Focal                      |                2  2                                         3            |             
      Prepuce, Hemorrhage                  |                                                                          |             
      Subcutaneous Tissue, Edema           |    4                                                           3         |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    |                +                                   +                     |             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cerebellum, Hemorrhage               |                            2                                             |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Congestion                           |                               3                                          |             
      Foreign Body                         |                                                                          |             
      Hemorrhage                           |                               2                                          |             
      Hyperplasia, Lymphoid                | 2  2     2  2        2  2  1  2  2  2  2  2  2  2  2  1  2  2  2  2  2  2|             
      Infiltration Cellular, Histiocyte    | 2                                               2           4            |             
      Inflammation, Acute, Multifocal      |                                                                          |             
      Thrombosis                           |                                                                          |             
      Thrombosis, Multiple                 | X                                                                        |             
      Alveolar Epithelium, Hyperplasia,    |                                                                          |             
           Focal                           |                                                                          |             
      Alveolar Epithelium, Hyperplasia,    |                                                                          |             
           Multifocal                      | 2                             1                             2            |             
      Mediastinum, Inflammation, Acute     |                                                                          |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Foreign Body                         |                                                                          |             
      Fungus                               | 3                                   4                                    |             
 _____________________________________________________________________________________________________________________|             
                                                             Page 101                                                               
NTP Experiment-Test: 05172-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                               3,3-DIMETHOXYBENZIDINE DIHYDROCHLORIDE                          Date: 04/30/97  
Route: DOSED WATER                                                                                                Time: 17:38:14  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 5| 5| 5| 3| 5| 5| 5| 5| 4| 5| 5| 5| 5| 2| 5| 5| 5| 4| 4| 5| 5| 5| 5| 4|             
                             DAY ON TEST   | 9| 6| 4| 4| 3| 6| 6| 5| 5| 1| 9| 6| 4| 1| 8| 6| 5| 2| 8| 0| 6| 4| 3| 2| 4|             
                                           | 7| 0| 6| 2| 9| 0| 0| 0| 0| 9| 2| 0| 2| 1| 4| 0| 1| 5| 3| 2| 0| 6| 4| 7| 5|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|             
    330 PPM                                | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
      Hyperkeratosis                       |                      2                                                   |             
      Inflammation, Acute                  | 3                                                                        |             
      Inflammation, Chronic                |                                     2                                    |             
      Necrosis, Focal                      | 3                                                                        |             
      Glands, Hyperplasia                  |                                                                          |             
      Nasolacrimal Duct, Inflammation,     |                                                                          |             
           Acute                           |                                                          3               |             
      Submucosa, Fibrosis                  |                                                                          |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ear                                     |                                                                          |             
      Canal, Hyperplasia, Focal, Squamous  |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                                                                         +|             
      Cornea, Inflammation, Chronic        |                                                                          |             
                                            __________________________________________________________________________|             
   Zymbal's Gland                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Ectasia                              | 4     2  3  2     4  2     3  4        3  2     3  4  2  2  3  3  3  2  3|             
      Hyperplasia, Focal                   |       2                                                        1         |             
      Hyperplasia, Focal, Squamous         |                   1     2           1           1                       2|             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Abscess, Multifocal                  |                               3                                          |             
      Infarct, Acute                       |                                                 2                        |             
      Nephropathy, Chronic                 | 3  1  2     2  2     1  1  1     3  1  2  2  2  2     2  2  2  2     1  2|             
      Renal Tubule, Necrosis, Focal        |                                                                          |             
      Renal Tubule, Pigmentation           |                                           1                              |             
      Transitional Epithelium, Hyperplasia,|                                                                          |             
           Focal                           |                                                                          |             
                                            __________________________________________________________________________|             
   Urethra                                 |                                              +                           |             
      Hyperplasia, Focal, Squamous         |                                              2                           |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page 102                                                               
NTP Experiment-Test: 05172-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                               3,3-DIMETHOXYBENZIDINE DIHYDROCHLORIDE                          Date: 04/30/97  
Route: DOSED WATER                                                                                                Time: 17:38:14  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 5| 5| 4| 3| 5| 5| 4| 4| 4| 5| 5| 4| 4| 4| 5| 4| 4| 3| 3|              |            |
                             DAY ON TEST   | 9| 8| 1| 1| 3| 6| 3| 8| 7| 2| 2| 0| 8| 7| 2| 4| 2| 0| 3| 0|              |            |
                                           | 0| 5| 2| 4| 2| 1| 6| 5| 6| 3| 1| 6| 3| 7| 4| 1| 5| 1| 7| 4|              |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |      T     |
                               ANIMAL ID   | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|              |      A     |
    330 PPM                                | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|              |      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|              |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  60        |
      Hyperkeratosis                       |                                                    3                     |      1  3.0|
      Inflammation, Acute                  |                               3                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  58        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  58        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  58        |
      Parasite Metazoan                    |          X                                      X                        |      2     |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  58        |
                                            __________________________________________________________________________|____________|
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  58        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +               |  55        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  57        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +               |  56        |
      Necrosis, Focal                      |                               4                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  60        |
      Basophilic Focus                     |    2  3  1  1  2     2  1  2  3  2  2  2  1     2  2  2  2               |     49  1.9|
      Clear Cell Focus                     | 2     3        1  1                       1  1     1  1  2               |     28  1.7|
      Degeneration, Cystic, Focal          |                               2           2                              |      4  2.5|
      Degeneration, Cystic                 |             1     2                                1                     |     15  1.5|
      Degeneration, Cystic, Multifocal     | 4              2                 2  3        2                           |      9  2.7|
      Eosinophilic Focus                   | 2  2  3        3  2  3     2     2  4     2  4     2     2               |     38  2.5|
      Fatty Change                         |                                     2                                    |      3  2.0|
      Granuloma                            |                                           2        3                     |      3  2.7|
      Hematopoietic Cell Proliferation     | 2  1     2  1  2     2     2        2  1     2        1  1               |     41  1.6|
      Hepatodiaphragmatic Nodule           |                         X        X                                       |      2     |
      Necrosis, Coagulative                |                            3                                             |      1  3.0|
      Necrosis, Focal                      |             2                                   2                        |      5  2.0|
      Necrosis, Multifocal                 |                                                                          |      5  2.6|
      Regeneration, Diffuse                |                   3                                                      |      3  3.0|
      Regeneration, Focal                  |          3                             3                                 |      5  3.2|
      Regeneration, Multifocal             | 4                                                                        |     10  3.0|
      Thrombosis                           |                   X                 1                 2                  |      7  2.0|
      Vacuolization Cytoplasmic, Focal     |                               3                                          |      3  2.3|
      Vacuolization Cytoplasmic, Multifocal|                1                                                         |      7  2.1|
      Bile Duct, Hyperplasia               |    2                                                  2                  |      4  2.8|
      Centrilobular, Degeneration, Diffuse |                                        3              2                  |     10  2.6|
      Centrilobular, Necrosis, Diffuse     |          3        3                    4                                 |      5  3.4|
      Centrilobular, Necrosis              | 3                                                                        |      1  3.0|
      Periportal, Fibrosis                 |                                                                          |      1  4.0|
      Serosa, Inflammation, Acute          |                                                                          |      1  3.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page 103                                                               
NTP Experiment-Test: 05172-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                               3,3-DIMETHOXYBENZIDINE DIHYDROCHLORIDE                          Date: 04/30/97  
Route: DOSED WATER                                                                                                Time: 17:38:14  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 5| 5| 4| 3| 5| 5| 4| 4| 4| 5| 5| 4| 4| 4| 5| 4| 4| 3| 3|              |            |
                             DAY ON TEST   | 9| 8| 1| 1| 3| 6| 3| 8| 7| 2| 2| 0| 8| 7| 2| 4| 2| 0| 3| 0|              |            |
                                           | 0| 5| 2| 4| 2| 1| 6| 5| 6| 3| 1| 6| 3| 7| 4| 1| 5| 1| 7| 4|              |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |      T     |
                               ANIMAL ID   | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|              |      A     |
    330 PPM                                | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|              |      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|              |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mesentery                               | +              +                                      +                  |  11        |
      Inflammation, Acute                  |                                                                          |      1  4.0|
      Fat, Necrosis                        | 3              3                                      2                  |      9  2.8|
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  60        |
      Atrophy                              |                                                                          |      2  1.5|
      Degeneration                         |                                     2                                    |      1  2.0|
                                            __________________________________________________________________________|____________|
   Pharynx                                 |    +  +                 +                             +                  |   7        |
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  60        |
      Interlobular, Edema                  |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  59        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                  |  57        |
      Acanthosis, Diffuse                  |                                                                          |      1  2.0|
      Acanthosis                           |                                                                          |      2  3.0|
      Ulcer                                |                               3                                          |      2  3.0|
      Ulcer, Multifocal                    |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                  |  58        |
      Hemorrhage, Focal                    |                                                                          |      1  1.0|
      Necrosis, Focal                      |          3                                                               |      1  3.0|
                                            __________________________________________________________________________|____________|
   Tongue                                  |    +           +                                   +                     |  10        |
      Hyperkeratosis, Focal                |    2                                                                     |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  60        |
      Cardiomyopathy, Chronic              |    2  2     2     2  2  2           2  1  2  3  3  2  2  2               |     42  2.0|
      Inflammation, Acute, Multifocal      |                                                                          |      1  2.0|
      Atrium, Thrombosis                   | X                 X                 X        X        X                  |     23  3.0|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  60        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  60        |
      Angiectasis, Multifocal              |                                                                          |      1  2.0|
      Infarct, Chronic                     |                                                                          |      1  4.0|
      Vacuolization Cytoplasmic, Diffuse   |                                                       2                  |      4  2.3|
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  60        |
      Hyperplasia, Focal                   |                2           2                                             |      5  1.8|
      Hyperplasia, Multifocal              |                   2                          2                           |      5  1.8|
      Infarct, Chronic                     |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  60        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  60        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page 104                                                               
NTP Experiment-Test: 05172-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                               3,3-DIMETHOXYBENZIDINE DIHYDROCHLORIDE                          Date: 04/30/97  
Route: DOSED WATER                                                                                                Time: 17:38:14  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 5| 5| 4| 3| 5| 5| 4| 4| 4| 5| 5| 4| 4| 4| 5| 4| 4| 3| 3|              |            |
                             DAY ON TEST   | 9| 8| 1| 1| 3| 6| 3| 8| 7| 2| 2| 0| 8| 7| 2| 4| 2| 0| 3| 0|              |            |
                                           | 0| 5| 2| 4| 2| 1| 6| 5| 6| 3| 1| 6| 3| 7| 4| 1| 5| 1| 7| 4|              |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |      T     |
                               ANIMAL ID   | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|              |      A     |
    330 PPM                                | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|              |      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|              |            |
 __________________________________________________________________________________________________________________________________ 
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  59        |
      Pars Distalis, Cyst                  |                                                                          |      1  2.0|
      Pars Intermedia, Cyst                |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  60        |
      C-Cell, Hyperplasia, Focal           |       2                                                                  |      2  1.5|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  59        |
                                            __________________________________________________________________________|____________|
   Preputial Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  59        |
      Atrophy                              |                   3              3                    2                  |      7  2.7|
      Ectasia                              |    3  3        3                 4  3     2     2  2                     |     24  3.0|
      Hyperplasia, Focal                   |             2                    2     3        2                        |      8  1.9|
      Hyperplasia, Focal, Squamous         |          2           2                                                   |      4  1.8|
      Inflammation, Acute                  |                                                                          |      1  4.0|
      Inflammation, Chronic                |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  60        |
      Hyperplasia, Focal, Glandular        | 3                                                                        |      2  2.0|
      Inflammation, Chronic Active         |                               3        2           2                     |     11  2.3|
                                            __________________________________________________________________________|____________|
   Seminal Vesicle                         | +  +  +  M  M  +  +  +  M  M  +  +  +  +  M  +  M  M  +  M               |  44        |
      Atrophy                              |                      3                                                   |      2  3.0|
                                            __________________________________________________________________________|____________|
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  59        |
      Atrophy                              |                      3                                                   |      4  3.8|
      Degeneration                         |                                                                          |      2  2.0|
      Interstitial Cell, Hyperplasia       |    2     2     2           2     1  1     1  2     2                     |     17  1.8|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood                                   |                                                                          |   1        |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  60        |
      Hyperplasia                          |    3              3                                                      |      7  2.9|
      Myelofibrosis, Focal                 |                                                                          |      2  2.5|
      Myelofibrosis                        |                1           1                                             |      3  1.0|
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  58        |
      Bronchial, Congestion                |                   3                                                      |      1  3.0|
      Inguinal, Hyperplasia, Lymphoid      |                                                                          |      1  3.0|
      Mediastinal, Congestion              |                   3                                                      |      1  3.0|
      Mediastinal, Hyperplasia, Lymphoid   | 3                                            3                           |      3  3.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page 105                                                               
NTP Experiment-Test: 05172-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                               3,3-DIMETHOXYBENZIDINE DIHYDROCHLORIDE                          Date: 04/30/97  
Route: DOSED WATER                                                                                                Time: 17:38:14  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 5| 5| 4| 3| 5| 5| 4| 4| 4| 5| 5| 4| 4| 4| 5| 4| 4| 3| 3|              |            |
                             DAY ON TEST   | 9| 8| 1| 1| 3| 6| 3| 8| 7| 2| 2| 0| 8| 7| 2| 4| 2| 0| 3| 0|              |            |
                                           | 0| 5| 2| 4| 2| 1| 6| 5| 6| 3| 1| 6| 3| 7| 4| 1| 5| 1| 7| 4|              |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |      T     |
                               ANIMAL ID   | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|              |      A     |
    330 PPM                                | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|              |      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|              |            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
      Mediastinal, Pigmentation            |                                                                          |      1  3.0|
      Pancreatic, Congestion               |                   3                                                      |      1  3.0|
      Pancreatic, Hyperplasia, Reticulum   |                                                                          |            |
          Cell                             |    4                                                                     |      1  4.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  58        |
      Congestion                           |                   3                                                      |      1  3.0|
      Hyperplasia, Lymphoid                |                                                          2               |      6  2.3|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  56        |
      Congestion                           |                   3                                                      |      1  3.0|
      Hyperplasia, Lymphoid                |                                              3                           |      3  3.0|
      Hyperplasia, Reticulum Cell          |                                                       2  2               |      6  2.5|
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  59        |
      Angiectasis, Focal                   |                                                                          |      2  3.0|
      Atrophy                              |                         3                                                |      4  3.0|
      Hematopoietic Cell Proliferation     |    3     4  3  4     3     3  2     3  3     4        3                  |     38  3.2|
      Hyperplasia, Megakaryocyte           |                                                                          |      1  3.0|
      Hyperplasia, Reticulum Cell          |                      3           3                                       |      7  3.1|
      Metaplasia                           |                                                                          |      1  2.0|
      Necrosis, Multifocal                 |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Thymus                                  | M  +  M  +  +  M  +  +  +  M  M  +  +  +  +  +  +  +  +  +               |  48        |
      Hemorrhage                           |                                                                          |      1  4.0|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +  +  +  +  +  M  +  +  +  +  +  +  M  +  +  +  +  +               |  56        |
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  60        |
      Acanthosis, Focal                    |                                                                          |      1  4.0|
      Dermis, Fibrosis, Focal              |                                                                          |      1  3.0|
      Dermis, Fibrosis                     |       3                                                                  |      1  3.0|
      Hair Follicle, Hyperplasia, Basal    |                                                                          |            |
          Cell, Focal                      |                                                                          |      3  2.3|
      Prepuce, Hemorrhage                  |                                  3                                       |      1  3.0|
      Subcutaneous Tissue, Edema           |                   3                                                      |      3  3.3|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    |    +  +                                   +                              |   6        |
                                            __________________________________________________________________________|____________|
   Skeletal Muscle                         |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  60        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page 106                                                               
NTP Experiment-Test: 05172-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                               3,3-DIMETHOXYBENZIDINE DIHYDROCHLORIDE                          Date: 04/30/97  
Route: DOSED WATER                                                                                                Time: 17:38:14  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 5| 5| 4| 3| 5| 5| 4| 4| 4| 5| 5| 4| 4| 4| 5| 4| 4| 3| 3|              |            |
                             DAY ON TEST   | 9| 8| 1| 1| 3| 6| 3| 8| 7| 2| 2| 0| 8| 7| 2| 4| 2| 0| 3| 0|              |            |
                                           | 0| 5| 2| 4| 2| 1| 6| 5| 6| 3| 1| 6| 3| 7| 4| 1| 5| 1| 7| 4|              |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |      T     |
                               ANIMAL ID   | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|              |      A     |
    330 PPM                                | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|              |      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|              |            |
 __________________________________________________________________________________________________________________________________ 
 NERVOUS SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
      Cerebellum, Hemorrhage               |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  60        |
      Congestion                           |                                                                          |      1  3.0|
      Foreign Body                         |    2                                                                     |      1  2.0|
      Hemorrhage                           |                                                                          |      1  2.0|
      Hyperplasia, Lymphoid                | 2     2  2  2  2  2  1  2           1  1  2  3  2  2  2  2               |     52  2.0|
      Infiltration Cellular, Histiocyte    |                   2                          2                           |      6  2.3|
      Inflammation, Acute, Multifocal      |    4                                                                     |      1  4.0|
      Thrombosis                           |                               2                                          |      1  2.0|
      Thrombosis, Multiple                 |                                                                          |      2     |
      Alveolar Epithelium, Hyperplasia,    |                                                                          |            |
           Focal                           |                                                                          |      1  2.0|
      Alveolar Epithelium, Hyperplasia,    |                                                                          |            |
           Multifocal                      |                                                                          |      3  1.7|
      Mediastinum, Inflammation, Acute     |                               4                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  60        |
      Foreign Body                         |    3                                                                     |      1  3.0|
      Fungus                               |                            2  3  3  3                    2               |      7  2.9|
      Hyperkeratosis                       |                                                                          |      1  2.0|
      Inflammation, Acute                  |    3                                                     2               |      4  2.5|
      Inflammation, Chronic                |                            2                                             |      3  2.3|
      Necrosis, Focal                      |                                                                          |      2  3.0|
      Glands, Hyperplasia                  |                            2                                             |      1  2.0|
      Nasolacrimal Duct, Inflammation,     |                                                                          |            |
           Acute                           |                                                                          |      1  3.0|
      Submucosa, Fibrosis                  |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  60        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Ear                                     |                +     +                                                   |   2        |
      Canal, Hyperplasia, Focal, Squamous  |                3                                                         |      1  3.0|
                                            __________________________________________________________________________|____________|
   Eye                                     |                                                                          |   2        |
      Cornea, Inflammation, Chronic        |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Zymbal's Gland                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  60        |
      Ectasia                              | 2  2           2  3  2  2     2  3  2        2        2                  |     40  2.6|
      Hyperplasia, Focal                   |                                                                          |      2  1.5|
      Hyperplasia, Focal, Squamous         |       1           1        1                                             |     12  1.3|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page 107                                                               
NTP Experiment-Test: 05172-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                               3,3-DIMETHOXYBENZIDINE DIHYDROCHLORIDE                          Date: 04/30/97  
Route: DOSED WATER                                                                                                Time: 17:38:14  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 5| 5| 4| 3| 5| 5| 4| 4| 4| 5| 5| 4| 4| 4| 5| 4| 4| 3| 3|              |            |
                             DAY ON TEST   | 9| 8| 1| 1| 3| 6| 3| 8| 7| 2| 2| 0| 8| 7| 2| 4| 2| 0| 3| 0|              |            |
                                           | 0| 5| 2| 4| 2| 1| 6| 5| 6| 3| 1| 6| 3| 7| 4| 1| 5| 1| 7| 4|              |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |      T     |
                               ANIMAL ID   | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|              |      A     |
    330 PPM                                | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|              |      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|              |            |
 __________________________________________________________________________________________________________________________________ 
 SPECIAL SENSES SYSTEM - cont              |                                                                          |            |
                                           |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  60        |
      Abscess, Multifocal                  |                                                                          |      1  3.0|
      Infarct, Acute                       |                                                                          |      1  2.0|
      Nephropathy, Chronic                 | 2  1  3     2  2  2  2     2  1  1  2  2  2  2  1  2  1  2               |     52  1.8|
      Renal Tubule, Necrosis, Focal        |          2  3                                                            |      2  2.5|
      Renal Tubule, Pigmentation           |                                                       1                  |      3  1.7|
      Transitional Epithelium, Hyperplasia,|                                                                          |            |
           Focal                           |                                           2                              |      1  2.0|
                                            __________________________________________________________________________|____________|
   Urethra                                 |                                                                          |   1        |
      Hyperplasia, Focal, Squamous         |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  59        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page 108                                                               
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