TDMS Study 05180-06 Pathology Tables
NTP Experiment-Test: 05180-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC GALLIUM ARSENIDE Date: 02/17/99
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:17:39
2 YEAR CHRONIC RATS
Facility: Battelle Northwest
Chemical CAS #: 1303-00-0000
Lock Date: 03/13/97
Cage Range: All
Reasons For Removal: All
Removal Date Range: All
Treatment Groups: Include All
Page 1
NTP Experiment-Test: 05180-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC GALLIUM ARSENIDE Date: 02/17/99
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:17:39
_____________________________________________________________________________________________________________________
| 7| 7| 7| 6| 6| 3| 7| 7| 7| 7| 3| 5| 7| 5| 7| 5| 6| 7| 7| 6| 7| 5| 7| 6| 6|
DAY ON TEST | 3| 3| 3| 0| 4| 1| 3| 3| 3| 3| 0| 8| 3| 8| 1| 9| 8| 3| 3| 2| 3| 8| 3| 8| 2|
| 5| 5| 4| 7| 2| 0| 4| 0| 4| 5| 2| 8| 5| 2| 6| 0| 8| 0| 4| 1| 5| 9| 5| 4| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
CONTROL | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 2 |
Basophilic Focus | X X X X X X X X X X X X X X X X X X X|
Clear Cell Focus | X X X |
Eosinophilic Focus | X X |
Fatty Change | 2 2 2 2 4 1 |
Hepatodiaphragmatic Nodule | X |
Inflammation, Granulomatous | 2 3|
Mixed Cell Focus | X X X X X|
Necrosis | |
Regeneration | 2 2 |
Vacuolization Cytoplasmic, Focal | 2 2 |
Bile Duct, Hyperplasia | 2 2 1 1 2 2 2 2 1 |
Centrilobular, Necrosis | 4 1 1 |
__________________________________________________________________________|
Mesentery | + + + |
Fat, Necrosis | 2 2 2 |
__________________________________________________________________________|
Oral Mucosa | |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 2 1 1 2 1 1 2 1 1 2 |
Basophilic Focus | X X X X |
Hyperplasia | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Necrosis | 3 3 2 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mineralization | |
Necrosis | 1 1|
__________________________________________________________________________|
Tooth | |
Inflammation, Chronic Active | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | 2 1 2 1 2 2 2 2 1 1 2 1 2 2 1|
Atrium, Thrombosis | 4 4 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NTP Experiment-Test: 05180-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC GALLIUM ARSENIDE Date: 02/17/99
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:17:39
_____________________________________________________________________________________________________________________
| 7| 7| 7| 6| 6| 3| 7| 7| 7| 7| 3| 5| 7| 5| 7| 5| 6| 7| 7| 6| 7| 5| 7| 6| 6|
DAY ON TEST | 3| 3| 3| 0| 4| 1| 3| 3| 3| 3| 0| 8| 3| 8| 1| 9| 8| 3| 3| 2| 3| 8| 3| 8| 2|
| 5| 5| 4| 7| 2| 0| 4| 0| 4| 5| 2| 8| 5| 2| 6| 0| 8| 0| 4| 1| 5| 9| 5| 4| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
CONTROL | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
Degeneration, Cystic | 3 2 |
Hyperplasia | 2 1 2 2 2 2 2 2 2 2 2 2 2 |
Hypertrophy | 2 2 2 3 2 |
Vacuolization Cytoplasmic | 2 2 |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 1 1 2 1 2 2 2 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + + M + + + + + + + + + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | 2 |
Pars Distalis, Hyperplasia | 2 3 3 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
C-Cell, Hyperplasia | 3 1 1 2 2 2 2 1 2 2 2 2 1 1 2 1 2 1|
Follicular Cell, Hyperplasia | 1|
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 3 |
Inflammation, Chronic Active | |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | 3 3 2 |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Granulomatous | 2 |
Myelofibrosis | 2 |
__________________________________________________________________________|
Lymph Node | + + |
__________________________________________________________________________|
Lymph Node, Bronchial | + + M + M M + + M + + + + M + + + + + + + + + + M|
Infiltration Cellular, Plasma Cell | |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + M + + + + + M + + + + + + + + M + + + + + +|
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node, Mediastinal | M M + + + M + M + + M + + + + + + + + + + + M M +|
Infiltration Cellular, | |
Polymorphonuclear | |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrosis | 1 |
Hematopoietic Cell Proliferation | 2 4 4 |
__________________________________________________________________________|
Thymus | + + + + + + + M M + M + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
_____________________________________________________________________________________________________________________|
NTP Experiment-Test: 05180-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC GALLIUM ARSENIDE Date: 02/17/99
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:17:39
_____________________________________________________________________________________________________________________
| 7| 7| 7| 6| 6| 3| 7| 7| 7| 7| 3| 5| 7| 5| 7| 5| 6| 7| 7| 6| 7| 5| 7| 6| 6|
DAY ON TEST | 3| 3| 3| 0| 4| 1| 3| 3| 3| 3| 0| 8| 3| 8| 1| 9| 8| 3| 3| 2| 3| 8| 3| 8| 2|
| 5| 5| 4| 7| 2| 0| 4| 0| 4| 5| 2| 8| 5| 2| 6| 0| 8| 0| 4| 1| 5| 9| 5| 4| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
CONTROL | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM - cont | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Galactocele | 4 |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrous Osteodystrophy | |
Hyperostosis | 2 3 2 |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 1 1 |
Inflammation, Chronic Active | 1 4 |
Metaplasia, Squamous | 1 1 1 1 2 |
Necrosis | 4 |
Epiglottis, Hyperplasia | |
Epiglottis, Inflammation, Chronic | |
Active | 1 2 |
Epiglottis, Metaplasia, Squamous | 1 4 |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | 1 1 1 2 1 |
Mineralization | |
Proteinosis | 1 |
Alveolar Epithelium, Hyperplasia | 3 1 1 1 1 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Suppurative | 2 3 |
Thrombosis | 2 3 |
Olfactory Epithelium, Degeneration, | |
Hyaline | 1 1 1 1 1 1 2 3 1 2 1 1 2 3 1 1 1 1 1|
Respiratory Epithelium, Hyperplasia | |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + |
Cataract | 3 |
Retina, Atrophy | 4 |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Amyloid Deposition | 3 |
Inflammation, Suppurative | |
_____________________________________________________________________________________________________________________|
NTP Experiment-Test: 05180-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC GALLIUM ARSENIDE Date: 02/17/99
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:17:39
_____________________________________________________________________________________________________________________
| 7| 7| 7| 6| 6| 3| 7| 7| 7| 7| 3| 5| 7| 5| 7| 5| 6| 7| 7| 6| 7| 5| 7| 6| 6|
DAY ON TEST | 3| 3| 3| 0| 4| 1| 3| 3| 3| 3| 0| 8| 3| 8| 1| 9| 8| 3| 3| 2| 3| 8| 3| 8| 2|
| 5| 5| 4| 7| 2| 0| 4| 0| 4| 5| 2| 8| 5| 2| 6| 0| 8| 0| 4| 1| 5| 9| 5| 4| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
CONTROL | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM - cont | |
| |
Nephropathy | 2 2 2 2 4 2 2 2 2 1 2 2 3 2 2 3 2 1 2 1 2 3 3|
Renal Tubule, Hyperplasia | 4 |
Renal Tubule, Necrosis | 3 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NTP Experiment-Test: 05180-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC GALLIUM ARSENIDE Date: 02/17/99
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:17:39
__________________________________________________________________________________________________________________________________
| 6| 7| 6| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 6| 5| 6| 5| 7| 6| 6| 6| 6| 7| 7| 4| |
DAY ON TEST | 7| 3| 6| 6| 3| 3| 3| 1| 8| 3| 0| 3| 3| 6| 0| 9| 8| 3| 0| 4| 7| 7| 3| 0| 9| |
| 7| 4| 0| 0| 4| 4| 5| 6| 5| 4| 2| 4| 4| 0| 6| 9| 1| 5| 4| 9| 9| 8| 5| 3| 7| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| A |
CONTROL | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Angiectasis | 2 | 2 2.0|
Basophilic Focus | X X X X X X X X X X X X X X X X X X X| 38 |
Clear Cell Focus | X X | 5 |
Eosinophilic Focus | | 2 |
Fatty Change | 3 2 1 4 1 1 | 12 2.1|
Hepatodiaphragmatic Nodule | X X | 3 |
Inflammation, Granulomatous | 1 | 3 2.0|
Mixed Cell Focus | X X X X X | 10 |
Necrosis | 2 | 1 2.0|
Regeneration | | 2 2.0|
Vacuolization Cytoplasmic, Focal | 2 | 3 2.0|
Bile Duct, Hyperplasia | 1 2 2 1 2 2 | 15 1.7|
Centrilobular, Necrosis | 1 1 3 | 6 1.8|
__________________________________________________________________________|____________|
Mesentery | + + + | 6 |
Fat, Necrosis | 3 3 3 | 6 2.5|
__________________________________________________________________________|____________|
Oral Mucosa | + | 1 |
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Atrophy | 1 4 1 2 1 | 15 1.5|
Basophilic Focus | | 4 |
Hyperplasia | 2 3 2 | 3 2.3|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Necrosis | 3 | 4 2.8|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Mineralization | 2 1 | 2 1.5|
Necrosis | 2 | 3 1.3|
__________________________________________________________________________|____________|
Tooth | + | 1 |
Inflammation, Chronic Active | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
NTP Experiment-Test: 05180-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC GALLIUM ARSENIDE Date: 02/17/99
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:17:39
__________________________________________________________________________________________________________________________________
| 6| 7| 6| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 6| 5| 6| 5| 7| 6| 6| 6| 6| 7| 7| 4| |
DAY ON TEST | 7| 3| 6| 6| 3| 3| 3| 1| 8| 3| 0| 3| 3| 6| 0| 9| 8| 3| 0| 4| 7| 7| 3| 0| 9| |
| 7| 4| 0| 0| 4| 4| 5| 6| 5| 4| 2| 4| 4| 0| 6| 9| 1| 5| 4| 9| 9| 8| 5| 3| 7| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| A |
CONTROL | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM - cont | | |
| | |
Cardiomyopathy | 2 1 1 1 1 2 2 1 2 2 1 2 1 2 1 1 2 2 1| 34 1.5|
Atrium, Thrombosis | | 2 4.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Degeneration, Cystic | 1 2 | 4 2.0|
Hyperplasia | 2 2 2 2 2 2 2 2 2 2 2 2 2 2 | 27 2.0|
Hypertrophy | 2 2 2 2 1 | 10 2.0|
Vacuolization Cytoplasmic | | 2 2.0|
__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | 1 3 3 2 3 2 1 4 | 16 2.0|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + M + + + + + M +| 47 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cyst | | 1 2.0|
Pars Distalis, Hyperplasia | 2 2| 5 2.4|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
C-Cell, Hyperplasia | 1 1 1 1 2 2 2 2 2 2 2 2 1 1 2 1 2 2 1 1 1 2 2| 41 1.6|
Follicular Cell, Hyperplasia | | 1 1.0|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | 1 | 2 2.0|
Inflammation, Chronic Active | 4 2 | 2 3.0|
__________________________________________________________________________|____________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cyst | 3 2 3 3 | 7 2.7|
__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Granulomatous | | 1 2.0|
Myelofibrosis | | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node | + | 3 |
__________________________________________________________________________|____________|
Lymph Node, Bronchial | M + M + + + I M + + + + + + + M + + + M M M + + +| 36 |
Infiltration Cellular, Plasma Cell | 4| 1 4.0|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + M + + M + + + M + + + + + + + + + + M + + +| 43 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
NTP Experiment-Test: 05180-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC GALLIUM ARSENIDE Date: 02/17/99
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:17:39
__________________________________________________________________________________________________________________________________
| 6| 7| 6| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 6| 5| 6| 5| 7| 6| 6| 6| 6| 7| 7| 4| |
DAY ON TEST | 7| 3| 6| 6| 3| 3| 3| 1| 8| 3| 0| 3| 3| 6| 0| 9| 8| 3| 0| 4| 7| 7| 3| 0| 9| |
| 7| 4| 0| 0| 4| 4| 5| 6| 5| 4| 2| 4| 4| 0| 6| 9| 1| 5| 4| 9| 9| 8| 5| 3| 7| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| A |
CONTROL | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Lymph Node, Mediastinal | M + + M + + + + + M M + M + + + + + + M + M M M +| 34 |
Infiltration Cellular, | | |
Polymorphonuclear | 3| 1 3.0|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Fibrosis | 2 1 2 | 4 1.5|
Hematopoietic Cell Proliferation | 3 4| 5 3.4|
__________________________________________________________________________|____________|
Thymus | + + + + + + + M + + + + + + + + + + + + + M + + +| 45 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Galactocele | | 1 4.0|
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Fibrous Osteodystrophy | 3 | 1 3.0|
Hyperostosis | 1 2 1 4 | 7 2.1|
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | 1 | 3 1.0|
Inflammation, Chronic Active | 1 2 | 4 2.0|
Metaplasia, Squamous | 1 1 1 2 1| 10 1.2|
Necrosis | | 1 4.0|
Epiglottis, Hyperplasia | 1 1 2 1| 4 1.3|
Epiglottis, Inflammation, Chronic | | |
Active | 1 2 | 4 1.5|
Epiglottis, Metaplasia, Squamous | 1 1 | 4 1.8|
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Chronic Active | 1 1 1 1 1 1 | 11 1.1|
Mineralization | 1 | 1 1.0|
Proteinosis | | 1 1.0|
Alveolar Epithelium, Hyperplasia | 3 1 1 1 2 1 2 2 1 | 14 1.5|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Suppurative | 4 | 3 3.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
NTP Experiment-Test: 05180-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC GALLIUM ARSENIDE Date: 02/17/99
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:17:39
__________________________________________________________________________________________________________________________________
| 6| 7| 6| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 6| 5| 6| 5| 7| 6| 6| 6| 6| 7| 7| 4| |
DAY ON TEST | 7| 3| 6| 6| 3| 3| 3| 1| 8| 3| 0| 3| 3| 6| 0| 9| 8| 3| 0| 4| 7| 7| 3| 0| 9| |
| 7| 4| 0| 0| 4| 4| 5| 6| 5| 4| 2| 4| 4| 0| 6| 9| 1| 5| 4| 9| 9| 8| 5| 3| 7| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| A |
CONTROL | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont | | |
| | |
Thrombosis | | 2 2.5|
Olfactory Epithelium, Degeneration, | | |
Hyaline | 1 1 1 1 2 1 1 1 2 1 1 2 1 1 1 1 2 2 1 2| 39 1.3|
Respiratory Epithelium, Hyperplasia | 2 | 1 2.0|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | | 1 |
Cataract | | 1 3.0|
Retina, Atrophy | | 1 4.0|
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Amyloid Deposition | | 1 3.0|
Inflammation, Suppurative | 2| 1 2.0|
Nephropathy | 2 4 2 1 3 2 2 2 2 3 2 3 3 2 2 4 2 2 1 2 2 2 2 4 1| 48 2.2|
Renal Tubule, Hyperplasia | 2 | 2 3.0|
Renal Tubule, Necrosis | | 1 3.0|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
NTP Experiment-Test: 05180-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC GALLIUM ARSENIDE Date: 02/17/99
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:17:39
_____________________________________________________________________________________________________________________
| 7| 5| 5| 6| 7| 7| 7| 6| 6| 6| 7| 7| 7| 5| 7| 4| 7| 7| 4| 6| 5| 6| 6| 6| 7|
DAY ON TEST | 3| 6| 8| 1| 3| 3| 3| 9| 4| 8| 3| 3| 3| 9| 0| 9| 0| 3| 2| 2| 9| 3| 2| 6| 1|
| 4| 3| 5| 3| 5| 4| 4| 5| 9| 8| 5| 4| 5| 0| 2| 7| 2| 0| 2| 8| 0| 1| 1| 0| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
0.01 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
MG/M3 | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + A + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Acute | 2 |
__________________________________________________________________________|
Intestine Large, Rectum | + A + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + A + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Acute | 3 |
__________________________________________________________________________|
Intestine Small, Duodenum | + A + + + + + + + + I + + + + + + + + + + + + + +|
Necrosis | 2 |
__________________________________________________________________________|
Intestine Small, Jejunum | + A + A + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + A + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 2 |
Basophilic Focus | X X X X X X X X X X X X X X X X|
Clear Cell Focus | X X |
Eosinophilic Focus | X X |
Fatty Change | 1 2 2 2 2 3 2 1 3 1 3|
Hepatodiaphragmatic Nodule | X |
Inflammation, Granulomatous | |
Mixed Cell Focus | X |
Necrosis | |
Regeneration | 2 |
Bile Duct, Hyperplasia | 1 1 2 2 2 2 2 |
Centrilobular, Necrosis | 2 1 2 1 2 2 1 3 2 1 |
__________________________________________________________________________|
Mesentery | + + + |
Artery, Inflammation, Chronic Active | |
Fat, Necrosis | 3 2 2 |
__________________________________________________________________________|
Oral Mucosa | + + |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 1 2 2 1 2 1 |
Basophilic Focus | X |
Lipomatosis | 3 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + M + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Squamous | |
Necrosis | 3 3 2 3 1|
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mineralization | 1 |
Necrosis | 2 3 2 2 |
__________________________________________________________________________|
Tongue | |
Hyperplasia, Squamous | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | 1 1 1 2 2 2 1 1 2 2 1 2 1 1 1 1 2 1|
_____________________________________________________________________________________________________________________|
NTP Experiment-Test: 05180-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC GALLIUM ARSENIDE Date: 02/17/99
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:17:39
_____________________________________________________________________________________________________________________
| 7| 5| 5| 6| 7| 7| 7| 6| 6| 6| 7| 7| 7| 5| 7| 4| 7| 7| 4| 6| 5| 6| 6| 6| 7|
DAY ON TEST | 3| 6| 8| 1| 3| 3| 3| 9| 4| 8| 3| 3| 3| 9| 0| 9| 0| 3| 2| 2| 9| 3| 2| 6| 1|
| 4| 3| 5| 3| 5| 4| 4| 5| 9| 8| 5| 4| 5| 0| 2| 7| 2| 0| 2| 8| 0| 1| 1| 0| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
0.01 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
MG/M3 | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM - cont | |
| |
Atrium, Thrombosis | 2 2 4 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Degeneration, Cystic | |
Hyperplasia | 2 2 2 2 2 2 2 4 2 2 2 2 2|
Hypertrophy | 2 2 2 2 2 2 2 |
Necrosis | 2 2 2 2 |
Vacuolization Cytoplasmic | 2 2 |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + I + + + + + + + + + + + + +|
Hyperplasia | 2 1 2 2 2 2 1 4|
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + + M + + + M + + + M + + + + + + M + M + + + + +|
Hyperplasia | 1|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Hyperplasia | 2 3 |
__________________________________________________________________________|
Thyroid Gland | + A + + + + + + + + + + + + + + + + + + + + + + +|
C-Cell, Hyperplasia | 2 1 2 2 1 2 2 1 1 2 2 1 3 4 1 2 1 1 1|
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + + + + + + + + + + + + + + + + + M + + + + + +|
Hyperplasia | 2 2 3 |
Inflammation, Chronic Active | 2 |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | 2 3 |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + A + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Histiocytic | 3 |
__________________________________________________________________________|
Lymph Node | + + + +|
Renal, Hemorrhage | 2|
__________________________________________________________________________|
Lymph Node, Bronchial | + + + + + + + + M + M + + + + M + + + + + M + + M|
__________________________________________________________________________|
Lymph Node, Mandibular | + + M + + + + + + + + + + + M + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node, Mediastinal | M + + + + M + + M + + + + M + + + + + + + + + + +|
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrosis | 2 2 |
Hematopoietic Cell Proliferation | 3 |
Necrosis | 3 |
__________________________________________________________________________|
Thymus | + + + M + + + + + + + + + + + + + + + + + + M + +|
_____________________________________________________________________________________________________________________|
NTP Experiment-Test: 05180-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC GALLIUM ARSENIDE Date: 02/17/99
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:17:39
_____________________________________________________________________________________________________________________
| 7| 5| 5| 6| 7| 7| 7| 6| 6| 6| 7| 7| 7| 5| 7| 4| 7| 7| 4| 6| 5| 6| 6| 6| 7|
DAY ON TEST | 3| 6| 8| 1| 3| 3| 3| 9| 4| 8| 3| 3| 3| 9| 0| 9| 0| 3| 2| 2| 9| 3| 2| 6| 1|
| 4| 3| 5| 3| 5| 4| 4| 5| 9| 8| 5| 4| 5| 0| 2| 7| 2| 0| 2| 8| 0| 1| 1| 0| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
0.01 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
MG/M3 | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Atypical | 2 |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperostosis | 2 3 |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 1 |
Inflammation, Chronic Active | |
Metaplasia, Squamous | 1 1 1 1|
Epiglottis, Hyperplasia | |
Epiglottis, Inflammation, Chronic | |
Active | |
Epiglottis, Metaplasia, Squamous | 1 1 1 |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | 1 1 2 2 1 2 1 1 1 2 1 2 1 2 2 2 1 2 1 1 1 2|
Proteinosis | 1 1 1 1 1 1 1 1 1 1 1 1|
Thrombosis | 2 |
Alveolar Epithelium, Hyperplasia | 1 2 1 2 1|
Alveolar Epithelium, Metaplasia | 1 |
Artery, Mediastinum, Inflammation | |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Suppurative | 2 2 |
Thrombosis | 2 3 4 4 4 |
Olfactory Epithelium, Degeneration, | |
Hyaline | 2 2 1 2 1 2 1 1 2 2 2 1 2 1 1 1 2 2 1 1 1 1|
Olfactory Epithelium, Metaplasia, | |
Respiratory | 2 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + + +|
Cataract | 3 4 2|
Degeneration | |
Retina, Atrophy | 4 4 2|
__________________________________________________________________________|
Zymbal's Gland | |
_____________________________________________________________________________________________________________________|
NTP Experiment-Test: 05180-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC GALLIUM ARSENIDE Date: 02/17/99
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:17:39
_____________________________________________________________________________________________________________________
| 7| 5| 5| 6| 7| 7| 7| 6| 6| 6| 7| 7| 7| 5| 7| 4| 7| 7| 4| 6| 5| 6| 6| 6| 7|
DAY ON TEST | 3| 6| 8| 1| 3| 3| 3| 9| 4| 8| 3| 3| 3| 9| 0| 9| 0| 3| 2| 2| 9| 3| 2| 6| 1|
| 4| 3| 5| 3| 5| 4| 4| 5| 9| 8| 5| 4| 5| 0| 2| 7| 2| 0| 2| 8| 0| 1| 1| 0| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
0.01 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
MG/M3 | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM - cont | |
| |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | 4 |
Infarct | 4 2 3 |
Nephropathy | 2 2 2 2 2 2 2 3 3 2 2 3 2 2 4 1 2 3 2 1 3 2 4 4|
Renal Tubule, Hyperplasia | |
Renal Tubule, Necrosis | 3 |
Transitional Epithelium, Hyperplasia | 3 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | 2 |
_____________________________________________________________________________________________________________________|
NTP Experiment-Test: 05180-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC GALLIUM ARSENIDE Date: 02/17/99
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:17:39
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 5| 5| 7| 5| 3| 6| 7| 7| 7| 5| 7| 6| 7| 6| 7| 6| 7| 7| 4| 7| |
DAY ON TEST | 2| 2| 3| 3| 2| 5| 0| 3| 4| 1| 0| 0| 3| 3| 2| 3| 8| 1| 8| 3| 8| 3| 3| 7| 3| |
| 6| 3| 5| 4| 6| 9| 9| 4| 8| 0| 6| 0| 4| 5| 3| 4| 5| 4| 7| 5| 8| 5| 5| 8| 5| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| A |
0.01 | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
MG/M3 | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Inflammation, Acute | | 1 2.0|
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Inflammation, Acute | | 1 3.0|
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
Necrosis | | 1 2.0|
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Angiectasis | 2 | 2 2.0|
Basophilic Focus | X X X X X X X X X X X X X X X X X X X X| 36 |
Clear Cell Focus | X X X X X | 7 |
Eosinophilic Focus | X | 3 |
Fatty Change | 2 2 2 3 1 2 3 1| 19 2.0|
Hepatodiaphragmatic Nodule | X X | 3 |
Inflammation, Granulomatous | 1 | 1 1.0|
Mixed Cell Focus | X X X X X X X X | 9 |
Necrosis | 2 | 1 2.0|
Regeneration | | 1 2.0|
Bile Duct, Hyperplasia | 2 2 2 1 1 | 12 1.7|
Centrilobular, Necrosis | 1 1 1 | 13 1.5|
__________________________________________________________________________|____________|
Mesentery | + + + + + + + + + + + | 14 |
Artery, Inflammation, Chronic Active | 2 | 1 2.0|
Fat, Necrosis | 3 2 2 2 3 2 2 2 2 2 | 13 2.2|
__________________________________________________________________________|____________|
Oral Mucosa | | 2 |
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Atrophy | 2 2 1 2 2 2 1| 13 1.6|
Basophilic Focus | X X| 3 |
Lipomatosis | | 1 3.0|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia, Squamous | 3 | 1 3.0|
Necrosis | 2 4 | 7 2.6|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Mineralization | | 1 1.0|
Necrosis | 1 2 | 6 2.0|
__________________________________________________________________________|____________|
Tongue | + | 1 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
NTP Experiment-Test: 05180-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC GALLIUM ARSENIDE Date: 02/17/99
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:17:39
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 5| 5| 7| 5| 3| 6| 7| 7| 7| 5| 7| 6| 7| 6| 7| 6| 7| 7| 4| 7| |
DAY ON TEST | 2| 2| 3| 3| 2| 5| 0| 3| 4| 1| 0| 0| 3| 3| 2| 3| 8| 1| 8| 3| 8| 3| 3| 7| 3| |
| 6| 3| 5| 4| 6| 9| 9| 4| 8| 0| 6| 0| 4| 5| 3| 4| 5| 4| 7| 5| 8| 5| 5| 8| 5| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| A |
0.01 | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
MG/M3 | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
Hyperplasia, Squamous | 3 | 1 3.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cardiomyopathy | 1 1 2 1 1 1 1 2 2 2 2 1 1 1 1 1 2 1 2| 37 1.4|
Atrium, Thrombosis | | 3 2.7|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Degeneration, Cystic | 2 3 | 2 2.5|
Hyperplasia | 2 1 2 2 2 2 2 2 2 2| 23 2.0|
Hypertrophy | 1 2 1 1 | 11 1.7|
Necrosis | | 4 2.0|
Vacuolization Cytoplasmic | 2 2 | 4 2.0|
__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Hyperplasia | 2 1 1 | 11 1.8|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + + + + + + + + M + + + + + M + M + + +| 42 |
Hyperplasia | 2 1 | 3 1.3|
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Pars Distalis, Hyperplasia | 2 | 3 2.3|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
C-Cell, Hyperplasia | 1 1 1 2 1 2 2 2 1 2 2 1 2 2 2 3 2 1 1 1 2 1| 41 1.6|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + M + +| 48 |
Hyperplasia | 3 | 4 2.5|
Inflammation, Chronic Active | 2 | 2 2.0|
__________________________________________________________________________|____________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cyst | 3 2 3 4 2 1 | 8 2.5|
__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Hyperplasia, Histiocytic | | 1 3.0|
__________________________________________________________________________|____________|
Lymph Node | + + | 6 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
NTP Experiment-Test: 05180-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC GALLIUM ARSENIDE Date: 02/17/99
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:17:39
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 5| 5| 7| 5| 3| 6| 7| 7| 7| 5| 7| 6| 7| 6| 7| 6| 7| 7| 4| 7| |
DAY ON TEST | 2| 2| 3| 3| 2| 5| 0| 3| 4| 1| 0| 0| 3| 3| 2| 3| 8| 1| 8| 3| 8| 3| 3| 7| 3| |
| 6| 3| 5| 4| 6| 9| 9| 4| 8| 0| 6| 0| 4| 5| 3| 4| 5| 4| 7| 5| 8| 5| 5| 8| 5| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| A |
0.01 | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
MG/M3 | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
Renal, Hemorrhage | | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node, Bronchial | + + M M + + + M M + M + + + + M + M M + M + + + +| 36 |
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + + M + + + + + M M + + + + + +| 45 |
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Lymph Node, Mediastinal | M + + M + + + + + I M + + M + + + M + + + + M + +| 39 |
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Fibrosis | 2 2 2 2 | 6 2.0|
Hematopoietic Cell Proliferation | 3 | 2 3.0|
Necrosis | | 1 3.0|
__________________________________________________________________________|____________|
Thymus | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia, Atypical | | 1 2.0|
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperostosis | 2 | 3 2.3|
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | | 1 1.0|
Inflammation, Chronic Active | 1 2 1 1 2 | 5 1.4|
Metaplasia, Squamous | 3 | 5 1.4|
Epiglottis, Hyperplasia | 1 1 | 2 1.0|
Epiglottis, Inflammation, Chronic | | |
Active | 3 | 1 3.0|
Epiglottis, Metaplasia, Squamous | 3 3 3 | 6 2.0|
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Chronic Active | 1 2 1 2 2 2 1 2 1 1 2 2 2 2 1 2 1 1 2 2 1 2 2 2| 46 1.5|
Proteinosis | 1 1 1 1 1 1 1 1 1 1 1 1| 24 1.0|
Thrombosis | | 1 2.0|
Alveolar Epithelium, Hyperplasia | 1 3 1 2 | 9 1.6|
Alveolar Epithelium, Metaplasia | | 1 1.0|
Artery, Mediastinum, Inflammation | 3 | 1 3.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
NTP Experiment-Test: 05180-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC GALLIUM ARSENIDE Date: 02/17/99
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:17:39
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 5| 5| 7| 5| 3| 6| 7| 7| 7| 5| 7| 6| 7| 6| 7| 6| 7| 7| 4| 7| |
DAY ON TEST | 2| 2| 3| 3| 2| 5| 0| 3| 4| 1| 0| 0| 3| 3| 2| 3| 8| 1| 8| 3| 8| 3| 3| 7| 3| |
| 6| 3| 5| 4| 6| 9| 9| 4| 8| 0| 6| 0| 4| 5| 3| 4| 5| 4| 7| 5| 8| 5| 5| 8| 5| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| A |
0.01 | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
MG/M3 | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Suppurative | 1 2 | 4 1.8|
Thrombosis | 2 2 | 7 3.0|
Olfactory Epithelium, Degeneration, | | |
Hyaline | 2 1 1 2 2 2 1 1 1 1 2 1 2 2 2 2| 38 1.5|
Olfactory Epithelium, Metaplasia, | | |
Respiratory | 2 | 2 2.0|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | + +| 5 |
Cataract | 4 | 4 3.3|
Degeneration | 4| 1 4.0|
Retina, Atrophy | 3 | 4 3.3|
__________________________________________________________________________|____________|
Zymbal's Gland | + | 1 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cyst | | 1 4.0|
Infarct | | 3 3.0|
Nephropathy | 3 2 3 2 2 2 1 3 2 3 4 3 3 2 2 3 3 3 2 2 2 2 3| 47 2.4|
Renal Tubule, Hyperplasia | 3 | 1 3.0|
Renal Tubule, Necrosis | | 1 3.0|
Transitional Epithelium, Hyperplasia | | 1 3.0|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hemorrhage | | 1 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
NTP Experiment-Test: 05180-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC GALLIUM ARSENIDE Date: 02/17/99
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:17:39
_____________________________________________________________________________________________________________________
| 6| 7| 4| 5| 6| 6| 6| 7| 3| 7| 6| 1| 7| 6| 3| 4| 7| 7| 7| 7| 6| 6| 5| 6| 7|
DAY ON TEST | 4| 3| 6| 3| 0| 4| 0| 3| 3| 3| 6| 9| 3| 7| 5| 4| 3| 3| 3| 3| 4| 8| 4| 7| 3|
| 6| 4| 2| 4| 9| 6| 5| 5| 9| 5| 8| 8| 4| 8| 4| 8| 5| 5| 4| 4| 7| 4| 7| 4| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
0.1 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
MG/M3 | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + A + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + I + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + A + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + A + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + A + + + A + + + + + A + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + A + A + + + + + + + A + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 1 2|
Basophilic Focus | X X X X X X X X X X X X X X X X |
Clear Cell Focus | X X X X|
Eosinophilic Focus | X X |
Fatty Change | 3 2 1 3 2 |
Hepatodiaphragmatic Nodule | |
Mixed Cell Focus | X X X |
Necrosis | 2 3 2 |
Vacuolization Cytoplasmic, Focal | 3 |
Bile Duct, Hyperplasia | 2 2 2 |
Centrilobular, Necrosis | 2 2 2 2 1 1 |
__________________________________________________________________________|
Mesentery | + + + |
Fat, Necrosis | 3 2 2 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 1 2 1 2 1 1 2 1 1 1 1 2 1 |
Basophilic Focus | X |
Hyperplasia | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Squamous | |
Necrosis | 3 3 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mineralization | |
Necrosis | 2 |
__________________________________________________________________________|
Tongue | + |
Hyperplasia, Squamous | |
__________________________________________________________________________|
Tooth | +|
Developmental Malformation | X|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | 1 2 1 2 2 1 1 2 2 2 1 2|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Degeneration, Cystic | |
_____________________________________________________________________________________________________________________|
NTP Experiment-Test: 05180-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC GALLIUM ARSENIDE Date: 02/17/99
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:17:39
_____________________________________________________________________________________________________________________
| 6| 7| 4| 5| 6| 6| 6| 7| 3| 7| 6| 1| 7| 6| 3| 4| 7| 7| 7| 7| 6| 6| 5| 6| 7|
DAY ON TEST | 4| 3| 6| 3| 0| 4| 0| 3| 3| 3| 6| 9| 3| 7| 5| 4| 3| 3| 3| 3| 4| 8| 4| 7| 3|
| 6| 4| 2| 4| 9| 6| 5| 5| 9| 5| 8| 8| 4| 8| 4| 8| 5| 5| 4| 4| 7| 4| 7| 4| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
0.1 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
MG/M3 | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
Hyperplasia | 2 2 2 2 2 2 2 2 2 2 1 2|
Hypertrophy | 4 2 2 2 |
Necrosis | 2 |
Thrombosis | 2 |
Vacuolization Cytoplasmic | 2 2 2 |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 1 3 1 2 1 2 1 1 |
Bilateral, Hyperplasia | |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + M + + + +|
Hyperplasia | 1 |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 3 2 |
Pars Distalis, Hyperplasia | 4 3 3 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + A + + + + + + + + + +|
C-Cell, Hyperplasia | 3 2 2 3 2 1 2 1 1 1 1 1 2 2 2 1 1 1|
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + + + M + + + + + + + + + + + + + + + + M + + +|
Hyperplasia | 3 1 |
Inflammation, Chronic Active | |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | 3 3 2 3 |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + A + + + + + + + + + +|
Hemorrhage | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Necrosis | 4 |
__________________________________________________________________________|
Lymph Node | + + |
Renal, Hemorrhage | |
__________________________________________________________________________|
Lymph Node, Bronchial | + + M + + + + + + + M M M + M + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + M + + + + + + + + + M + + + + +|
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node, Mediastinal | + + M M + + + M M + + + + + M + + + + + + + M + +|
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrosis | 2 2 |
Hematopoietic Cell Proliferation | 2 4 3 4 |
Hemorrhage | |
Necrosis | |
__________________________________________________________________________|
Thymus | + + + + + M + + + + + + + + + + + + + M + M + + +|
_____________________________________________________________________________________________________________________|
NTP Experiment-Test: 05180-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC GALLIUM ARSENIDE Date: 02/17/99
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:17:39
_____________________________________________________________________________________________________________________
| 6| 7| 4| 5| 6| 6| 6| 7| 3| 7| 6| 1| 7| 6| 3| 4| 7| 7| 7| 7| 6| 6| 5| 6| 7|
DAY ON TEST | 4| 3| 6| 3| 0| 4| 0| 3| 3| 3| 6| 9| 3| 7| 5| 4| 3| 3| 3| 3| 4| 8| 4| 7| 3|
| 6| 4| 2| 4| 9| 6| 5| 5| 9| 5| 8| 8| 4| 8| 4| 8| 5| 5| 4| 4| 7| 4| 7| 4| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
0.1 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
MG/M3 | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Galactocele | 2 2 |
Hyperplasia, Atypical | |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrous Osteodystrophy | |
Hyperostosis | 3 2 |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | 1 2 |
Metaplasia, Squamous | 1 1 1 1 |
Epiglottis, Inflammation, Chronic | |
Active | |
Epiglottis, Metaplasia, Squamous | |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst, Squamous | 4 |
Hyperplasia, Atypical | 1 2 4 3 |
Inflammation, Chronic Active | 3 2 3 3 2 2 3 3 2 3 3 2 3 3 2 3 4 3 3 2 3 3 2 3|
Metaplasia, Squamous | 2 3 |
Proteinosis | 2 2 3 2 2 1 3 1 2 2 2 4 2 2 2 2 3 2 1 2 1 3 2 2|
Alveolar Epithelium, Hyperplasia | 3 1 2 3 3 1 2|
Alveolar Epithelium, Metaplasia | 2 3 3 1 2 3 3 2 2 1 3 3 3 3 2 2 2 3|
__________________________________________________________________________|
Nose | + + + + + + A + + + + + + + + + + + + + + + + + +|
Hemorrhage | |
Inflammation, Suppurative | 2 2 3 |
Thrombosis | 4 4 |
Olfactory Epithelium, Degeneration, | |
Hyaline | 1 1 2 2 1 1 1 1 2 1 1 1 3 3 2 1 2 3 2 1 |
Olfactory Epithelium, Metaplasia, | |
Respiratory | 2 1 |
Respiratory Epithelium, Metaplasia, | |
Squamous | 2 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + +|
_____________________________________________________________________________________________________________________|
NTP Experiment-Test: 05180-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC GALLIUM ARSENIDE Date: 02/17/99
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:17:39
_____________________________________________________________________________________________________________________
| 6| 7| 4| 5| 6| 6| 6| 7| 3| 7| 6| 1| 7| 6| 3| 4| 7| 7| 7| 7| 6| 6| 5| 6| 7|
DAY ON TEST | 4| 3| 6| 3| 0| 4| 0| 3| 3| 3| 6| 9| 3| 7| 5| 4| 3| 3| 3| 3| 4| 8| 4| 7| 3|
| 6| 4| 2| 4| 9| 6| 5| 5| 9| 5| 8| 8| 4| 8| 4| 8| 5| 5| 4| 4| 7| 4| 7| 4| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
0.1 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
MG/M3 | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM - cont | |
| |
Cataract | 4 |
Degeneration | 4|
Retina, Atrophy | 4 |
Sclera, Inflammation, Acute | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | |
Hydronephrosis | 3 |
Infarct | 2 |
Nephropathy | 2 2 2 1 2 2 3 2 1 3 2 3 2 3 3 3 4 2 2 2 2 3|
Renal Tubule, Hyperplasia | 4 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NTP Experiment-Test: 05180-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC GALLIUM ARSENIDE Date: 02/17/99
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:17:39
__________________________________________________________________________________________________________________________________
| 7| 7| 6| 5| 7| 7| 7| 6| 6| 6| 7| 7| 7| 7| 7| 6| 7| 7| 6| 7| 7| 3| 6| 6| 6| |
DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 0| 7| 6| 0| 3| 3| 2| 3| 7| 3| 3| 0| 3| 3| 1| 3| 7| 3| |
| 4| 5| 1| 4| 4| 4| 5| 4| 9| 0| 1| 5| 4| 3| 4| 4| 5| 5| 3| 5| 4| 0| 9| 4| 0| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| A |
0.1 | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
MG/M3 | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + A + + + + + + + + + + + + + +| 48 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + A + + + + + + + + + + + + + +| 48 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + A + + + + + + + + + + + + + +| 48 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + A + + + + + + + + + + + + + +| 46 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + A + + + + + + + + + + + + + +| 46 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Angiectasis | 1 1 2| 5 1.4|
Basophilic Focus | X X X X X X X X X X X X X X X X X X X X X X| 38 |
Clear Cell Focus | X X X X | 8 |
Eosinophilic Focus | X | 3 |
Fatty Change | 2 4 2 1 2 2 | 11 2.2|
Hepatodiaphragmatic Nodule | X X X | 3 |
Mixed Cell Focus | X X X | 6 |
Necrosis | 1 | 4 2.0|
Vacuolization Cytoplasmic, Focal | 2 | 2 2.5|
Bile Duct, Hyperplasia | 1 1 2 2 | 7 1.7|
Centrilobular, Necrosis | 2 2 | 8 1.8|
__________________________________________________________________________|____________|
Mesentery | + + + | 6 |
Fat, Necrosis | 2 2 2 | 6 2.2|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Atrophy | 2 2 2 2 1 2 1 2 | 21 1.5|
Basophilic Focus | | 1 |
Hyperplasia | 3 | 1 3.0|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia, Squamous | 2 | 1 2.0|
Necrosis | 2 | 3 2.7|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Mineralization | 2 1| 2 1.5|
Necrosis | 1 | 2 1.5|
__________________________________________________________________________|____________|
Tongue | + | 2 |
Hyperplasia, Squamous | 3 | 1 3.0|
__________________________________________________________________________|____________|
Tooth | | 1 |
Developmental Malformation | | 1 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
NTP Experiment-Test: 05180-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC GALLIUM ARSENIDE Date: 02/17/99
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:17:39
__________________________________________________________________________________________________________________________________
| 7| 7| 6| 5| 7| 7| 7| 6| 6| 6| 7| 7| 7| 7| 7| 6| 7| 7| 6| 7| 7| 3| 6| 6| 6| |
DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 0| 7| 6| 0| 3| 3| 2| 3| 7| 3| 3| 0| 3| 3| 1| 3| 7| 3| |
| 4| 5| 1| 4| 4| 4| 5| 4| 9| 0| 1| 5| 4| 3| 4| 4| 5| 5| 3| 5| 4| 0| 9| 4| 0| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| A |
0.1 | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
MG/M3 | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM - cont | | |
| | |
Cardiomyopathy | 2 1 1 1 1 1 1 2 1 2 1 2 1 1 1 1 1 | 29 1.4|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Degeneration, Cystic | 2 | 1 2.0|
Hyperplasia | 2 2 2 2 2 2 1 2 2 2 2 2 2 | 25 1.9|
Hypertrophy | 2 2 2 3 2 | 9 2.3|
Necrosis | 2 | 2 2.0|
Thrombosis | | 1 2.0|
Vacuolization Cytoplasmic | 2 | 4 2.0|
__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | 2 2 2 3 2 2 2 | 15 1.8|
Bilateral, Hyperplasia | 2 | 1 2.0|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + M + + + + + + + + + + + I + + + + + + + +| 47 |
Hyperplasia | 3 2 | 3 2.0|
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Angiectasis | | 2 2.5|
Pars Distalis, Hyperplasia | 4 3 4 2 | 7 3.3|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + A + + + + + + + + + + + + + +| 48 |
C-Cell, Hyperplasia | 1 1 2 1 2 2 1 2 2 1 2 2 1 1 1 1 1 2 4 2 | 38 1.6|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Clitoral Gland | + + + + + + + + + + + + + + + + + M + + + + + + +| 47 |
Hyperplasia | 4 | 3 2.7|
Inflammation, Chronic Active | 3 | 1 3.0|
__________________________________________________________________________|____________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cyst | 2 3 2 2 3 1 | 10 2.4|
__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Hemorrhage | 3 | 1 3.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Necrosis | | 1 4.0|
__________________________________________________________________________|____________|
Lymph Node | + | 3 |
Renal, Hemorrhage | 2 | 1 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
NTP Experiment-Test: 05180-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC GALLIUM ARSENIDE Date: 02/17/99
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:17:39
__________________________________________________________________________________________________________________________________
| 7| 7| 6| 5| 7| 7| 7| 6| 6| 6| 7| 7| 7| 7| 7| 6| 7| 7| 6| 7| 7| 3| 6| 6| 6| |
DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 0| 7| 6| 0| 3| 3| 2| 3| 7| 3| 3| 0| 3| 3| 1| 3| 7| 3| |
| 4| 5| 1| 4| 4| 4| 5| 4| 9| 0| 1| 5| 4| 3| 4| 4| 5| 5| 3| 5| 4| 0| 9| 4| 0| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| A |
0.1 | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
MG/M3 | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Lymph Node, Bronchial | M + + + + + + + + + M + + M M + + + M + + M + + +| 39 |
__________________________________________________________________________|____________|
Lymph Node, Mandibular | M + M + + + + + + + + M + + + + + + + + + + + + +| 45 |
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Lymph Node, Mediastinal | + + M + + + + M + + + + M M + M + + + + + + + + +| 39 |
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Fibrosis | 2 2 2 | 5 2.0|
Hematopoietic Cell Proliferation | 2 3 | 6 3.0|
Hemorrhage | 3 | 1 3.0|
Necrosis | 2 | 1 2.0|
__________________________________________________________________________|____________|
Thymus | + + + + + + M + + + + + + + M M M + + + M + + + M| 41 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Galactocele | | 2 2.0|
Hyperplasia, Atypical | 3 | 1 3.0|
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Fibrous Osteodystrophy | 1 | 1 1.0|
Hyperostosis | 2 4 3 3 3| 7 2.9|
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Chronic Active | 2 | 3 1.7|
Metaplasia, Squamous | 1 2 1| 7 1.1|
Epiglottis, Inflammation, Chronic | | |
Active | 1 | 1 1.0|
Epiglottis, Metaplasia, Squamous | 2 | 1 2.0|
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cyst, Squamous | | 1 4.0|
Hyperplasia, Atypical | 1 2 2 3 2 | 9 2.2|
Inflammation, Chronic Active | 3 3 3 3 3 2 3 3 2 3 3 3 3 2 3 3 3 3 3 3 3 3 2 3 3| 49 2.8|
Metaplasia, Squamous | | 2 2.5|
Proteinosis | 2 2 3 1 2 1 3 2 3 3 2 2 2 3 3 2 2 2 2 3 2 2 3| 47 2.2|
Alveolar Epithelium, Hyperplasia | 1 2 1 2 4 1 2 3 2 3 | 17 2.1|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
NTP Experiment-Test: 05180-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC GALLIUM ARSENIDE Date: 02/17/99
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:17:39
__________________________________________________________________________________________________________________________________
| 7| 7| 6| 5| 7| 7| 7| 6| 6| 6| 7| 7| 7| 7| 7| 6| 7| 7| 6| 7| 7| 3| 6| 6| 6| |
DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 0| 7| 6| 0| 3| 3| 2| 3| 7| 3| 3| 0| 3| 3| 1| 3| 7| 3| |
| 4| 5| 1| 4| 4| 4| 5| 4| 9| 0| 1| 5| 4| 3| 4| 4| 5| 5| 3| 5| 4| 0| 9| 4| 0| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| A |
0.1 | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
MG/M3 | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont | | |
| | |
Alveolar Epithelium, Metaplasia | 3 3 2 2 3 3 2 2 3 3 3 2 3 2 2 2 1 3| 36 2.4|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Hemorrhage | 3 | 1 3.0|
Inflammation, Suppurative | 1 2 2 1 3 2 | 9 2.0|
Thrombosis | 1 1 | 4 2.5|
Olfactory Epithelium, Degeneration, | | |
Hyaline | 1 1 1 2 1 2 1 2 1 2 1 1 2 | 33 1.5|
Olfactory Epithelium, Metaplasia, | | |
Respiratory | | 2 1.5|
Respiratory Epithelium, Metaplasia, | | |
Squamous | | 1 2.0|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | + + + + | 6 |
Cataract | | 1 4.0|
Degeneration | 3 3 4 | 4 3.5|
Retina, Atrophy | | 1 4.0|
Sclera, Inflammation, Acute | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cyst | 3 3| 2 3.0|
Hydronephrosis | | 1 3.0|
Infarct | | 1 2.0|
Nephropathy | 2 3 2 2 3 3 3 3 2 3 2 2 2 2 2 2 3 4 2 3 4 1 3 2 3| 47 2.4|
Renal Tubule, Hyperplasia | | 1 4.0|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
NTP Experiment-Test: 05180-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC GALLIUM ARSENIDE Date: 02/17/99
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:17:39
_____________________________________________________________________________________________________________________
| 6| 5| 5| 7| 5| 7| 7| 6| 6| 6| 6| 6| 6| 6| 7| 7| 5| 7| 7| 7| 5| 4| 7| 7| 6|
DAY ON TEST | 8| 9| 6| 3| 3| 3| 0| 7| 9| 3| 7| 3| 3| 3| 3| 0| 5| 3| 3| 0| 5| 2| 1| 3| 0|
| 5| 0| 4| 4| 4| 0| 9| 7| 1| 1| 4| 2| 1| 2| 5| 2| 4| 5| 4| 4| 6| 2| 2| 5| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
1.0 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
MG/M3 | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + A + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + A + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + A + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + A + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + A + + + + + + + + + + + + + + + + + + + + + +|
Necrosis | 2 2 |
__________________________________________________________________________|
Intestine Small, Jejunum | + + A + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + A + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 2 |
Basophilic Focus | X X X X X X X X X X X X X X X X X X X|
Clear Cell Focus | X X |
Degeneration, Cystic | 1 |
Eosinophilic Focus | |
Fatty Change | 1 2 1 1 2 2 2 |
Hepatodiaphragmatic Nodule | X X |
Inflammation, Granulomatous | 3 |
Mixed Cell Focus | X |
Necrosis | 2 2 |
Thrombosis | 2 |
Bile Duct, Hyperplasia | 1 3 2 1 2 2 3 |
Centrilobular, Necrosis | 2 1 2 1 1 1 1 1 1 |
__________________________________________________________________________|
Mesentery | + + + + + + |
Fat, Necrosis | 2 2 2 2 2 2 |
__________________________________________________________________________|
Pancreas | + + A + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 1 1 1 2 1 1 1 1 1 2|
Basophilic Focus | X |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Diverticulum | X |
Hyperplasia, Squamous | 3 |
Mineralization | 2 |
Necrosis | 4 1 3 |
__________________________________________________________________________|
Stomach, Glandular | + + A + + + + + + + + + + + + + + + + + + + + + +|
Mineralization | 1 3 |
Necrosis | 1 2 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | + |
Aorta, Mineralization | 4 |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | 1 1 1 2 1 1 2 1 1 1 1 1 3 1 |
Artery, Mineralization | 4 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
_____________________________________________________________________________________________________________________|
NTP Experiment-Test: 05180-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC GALLIUM ARSENIDE Date: 02/17/99
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:17:39
_____________________________________________________________________________________________________________________
| 6| 5| 5| 7| 5| 7| 7| 6| 6| 6| 6| 6| 6| 6| 7| 7| 5| 7| 7| 7| 5| 4| 7| 7| 6|
DAY ON TEST | 8| 9| 6| 3| 3| 3| 0| 7| 9| 3| 7| 3| 3| 3| 3| 0| 5| 3| 3| 0| 5| 2| 1| 3| 0|
| 5| 0| 4| 4| 4| 0| 9| 7| 1| 1| 4| 2| 1| 2| 5| 2| 4| 5| 4| 4| 6| 2| 2| 5| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
1.0 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
MG/M3 | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
| |
__________________________________________________________________________|
Adrenal Cortex | + + A + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 1 2 2 2 2 2 2 2 2 2|
Hypertrophy | 2 2 2 2 2 3 1 |
Necrosis | 2 3 |
Vacuolization Cytoplasmic | 2 2 |
__________________________________________________________________________|
Adrenal Medulla | + + A + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 1 3 3 2 2 1 |
__________________________________________________________________________|
Islets, Pancreatic | + + A + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | |
__________________________________________________________________________|
Parathyroid Gland | + + A + + + + + + + + + + + + + M + + + + + + + +|
Hyperplasia | 2 4 |
__________________________________________________________________________|
Pituitary Gland | + + A + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 2 |
Pars Distalis, Angiectasis | 3 |
Pars Distalis, Hyperplasia | 1 3 2 2 1 |
__________________________________________________________________________|
Thyroid Gland | + + A + + + + + + + + + + + + + + + + + + + + + +|
C-Cell, Hyperplasia | 2 1 2 2 1 1 2 1 2 1 1 2 2 2 2 1 1 2 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + + M + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | |
Inflammation, Chronic Active | 2 2 |
Metaplasia, Squamous | |
__________________________________________________________________________|
Ovary | + + A + + + + + + + + + + + + + + + + + + + + + +|
Cyst | 3 3 2 |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + A + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node | + + |
Renal, Hemorrhage | |
__________________________________________________________________________|
Lymph Node, Bronchial | + + A + + + + + + + + + + + M + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node, Mesenteric | + + A + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node, Mediastinal | + + + + + + + + M + + + + + M + + + M + + M + + +|
__________________________________________________________________________|
Spleen | + + A + + + + + + + + + + + + + + + + + + + + + +|
Fibrosis | 2 |
Hematopoietic Cell Proliferation | |
Hemorrhage | 2 3 |
__________________________________________________________________________|
Thymus | + + + + + + M M + + + + M + M + + + + + + + + + M|
_____________________________________________________________________________________________________________________|
NTP Experiment-Test: 05180-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC GALLIUM ARSENIDE Date: 02/17/99
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:17:39
_____________________________________________________________________________________________________________________
| 6| 5| 5| 7| 5| 7| 7| 6| 6| 6| 6| 6| 6| 6| 7| 7| 5| 7| 7| 7| 5| 4| 7| 7| 6|
DAY ON TEST | 8| 9| 6| 3| 3| 3| 0| 7| 9| 3| 7| 3| 3| 3| 3| 0| 5| 3| 3| 0| 5| 2| 1| 3| 0|
| 5| 0| 4| 4| 4| 0| 9| 7| 1| 1| 4| 2| 1| 2| 5| 2| 4| 5| 4| 4| 6| 2| 2| 5| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
1.0 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
MG/M3 | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrous Osteodystrophy | 4 |
Hyperostosis | 3 3 2 |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Larynx | + + A + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 1 |
Inflammation, Chronic Active | 3 1 1 |
Metaplasia, Squamous | 1 1 4 1 1 2 |
Epiglottis, Hyperplasia | 1 2 |
Epiglottis, Metaplasia, Squamous | 1 3 |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Atypical | 3 2 4 2 1 |
Inflammation, Chronic Active | 3 4 2 4 3 4 4 4 4 4 4 3 3 4 4 4 4 4 3 4 3 3 3 4 3|
Metaplasia, Squamous | 2 |
Mineralization | 4 |
Proteinosis | 3 4 2 4 4 4 4 3 4 3 3 4 3 4 3 4 4 4 4 4 4 4 2 4 3|
Alveolar Epithelium, Hyperplasia | 4 2 2 4 2 2 |
Alveolar Epithelium, Metaplasia | 2 2 3 2 2 2 2 2 3 3 3 2 2 2 3 3 3 2 2 3 3 3 2|
Artery, Mediastinum, Mineralization | 4 |
__________________________________________________________________________|
Nose | + + A + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Suppurative | 2 |
Thrombosis | 2 3 4 |
Olfactory Epithelium, Atrophy | 1 2 |
Olfactory Epithelium, Degeneration, | |
Hyaline | 2 3 1 2 2 2 1 1 1 2 1 1 1 1 1 1 2 |
Olfactory Epithelium, Metaplasia, | |
Respiratory | 3 |
__________________________________________________________________________|
Trachea | + + A + + + + + + + + + + + + + + + + + + + + + +|
Mineralization | 3 |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | |
__________________________________________________________________________|
Eye | + |
Cataract | 3 |
_____________________________________________________________________________________________________________________|
NTP Experiment-Test: 05180-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC GALLIUM ARSENIDE Date: 02/17/99
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:17:39
_____________________________________________________________________________________________________________________
| 6| 5| 5| 7| 5| 7| 7| 6| 6| 6| 6| 6| 6| 6| 7| 7| 5| 7| 7| 7| 5| 4| 7| 7| 6|
DAY ON TEST | 8| 9| 6| 3| 3| 3| 0| 7| 9| 3| 7| 3| 3| 3| 3| 0| 5| 3| 3| 0| 5| 2| 1| 3| 0|
| 5| 0| 4| 4| 4| 0| 9| 7| 1| 1| 4| 2| 1| 2| 5| 2| 4| 5| 4| 4| 6| 2| 2| 5| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
1.0 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
MG/M3 | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM - cont | |
| |
Retina, Atrophy | 3 |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + A + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | |
Infarct | 2 |
Mineralization | 3 |
Nephropathy | 2 2 3 2 2 3 2 4 2 2 3 2 4 1 3 2 4 2 1 4 2 2|
Thrombosis | |
Renal Tubule, Hyperplasia | 1 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NTP Experiment-Test: 05180-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC GALLIUM ARSENIDE Date: 02/17/99
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:17:39
__________________________________________________________________________________________________________________________________
| 3| 2| 7| 6| 7| 4| 6| 2| 6| 6| 7| 5| 4| 5| 5| 4| 7| 7| 6| 7| 7| 7| 6| 5| 7| |
DAY ON TEST | 1| 5| 1| 7| 3| 1| 9| 1| 7| 8| 3| 6| 7| 1| 0| 7| 3| 3| 9| 0| 3| 3| 8| 9| 1| |
| 0| 4| 2| 4| 4| 8| 1| 5| 7| 4| 4| 4| 8| 9| 6| 6| 4| 5| 6| 3| 4| 5| 8| 4| 6| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| A |
1.0 | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
MG/M3 | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Necrosis | | 2 2.0|
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Angiectasis | 2 2 | 3 2.0|
Basophilic Focus | X X X X X X X X X X X X X X X| 34 |
Clear Cell Focus | | 2 |
Degeneration, Cystic | | 1 1.0|
Eosinophilic Focus | X | 1 |
Fatty Change | 2 2 2 2 2 | 12 1.8|
Hepatodiaphragmatic Nodule | X X | 4 |
Inflammation, Granulomatous | | 1 3.0|
Mixed Cell Focus | X | 2 |
Necrosis | | 2 2.0|
Thrombosis | | 1 2.0|
Bile Duct, Hyperplasia | 2 1 1 2 2 3 | 13 1.9|
Centrilobular, Necrosis | 1 1 1 1 1 1 2 1 | 17 1.2|
__________________________________________________________________________|____________|
Mesentery | + + + + + | 11 |
Fat, Necrosis | 2 2 2 2 2 | 11 2.0|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Atrophy | 2 1 2 1 | 14 1.3|
Basophilic Focus | | 1 |
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Diverticulum | | 1 |
Hyperplasia, Squamous | 2 | 2 2.5|
Mineralization | | 1 2.0|
Necrosis | 4 | 4 3.0|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Mineralization | 1 | 3 1.7|
Necrosis | 2 3 | 4 2.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood Vessel | | 1 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
NTP Experiment-Test: 05180-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC GALLIUM ARSENIDE Date: 02/17/99
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:17:39
__________________________________________________________________________________________________________________________________
| 3| 2| 7| 6| 7| 4| 6| 2| 6| 6| 7| 5| 4| 5| 5| 4| 7| 7| 6| 7| 7| 7| 6| 5| 7| |
DAY ON TEST | 1| 5| 1| 7| 3| 1| 9| 1| 7| 8| 3| 6| 7| 1| 0| 7| 3| 3| 9| 0| 3| 3| 8| 9| 1| |
| 0| 4| 2| 4| 4| 8| 1| 5| 7| 4| 4| 4| 8| 9| 6| 6| 4| 5| 6| 3| 4| 5| 8| 4| 6| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| A |
1.0 | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
MG/M3 | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM - cont | | |
| | |
Aorta, Mineralization | | 1 4.0|
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cardiomyopathy | 1 1 1 2 2 1 2 1 1 3 1 1 1 1 2 2 2| 31 1.4|
Artery, Mineralization | | 1 4.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Hyperplasia | 2 2 2 2 2 2 2 2 2 2 2 2| 22 2.0|
Hypertrophy | 1 2 2 2 | 11 1.9|
Necrosis | | 2 2.5|
Vacuolization Cytoplasmic | 2 | 3 2.0|
__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Hyperplasia | 2 2 2 4 4 4 | 12 2.5|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Hyperplasia | 2 | 1 2.0|
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + + + + M + + + + + + + M + + + + + + +| 46 |
Hyperplasia | 3 | 3 3.0|
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Angiectasis | | 1 2.0|
Pars Distalis, Angiectasis | 4 | 2 3.5|
Pars Distalis, Hyperplasia | 4 3 4 2 | 9 2.4|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
C-Cell, Hyperplasia | 1 2 1 1 1 1 2 1 2 2 2 1 2 1 1| 33 1.5|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Clitoral Gland | + + + + + + + + M + + + + + + + + + + + + + + + +| 48 |
Hyperplasia | 2 4 | 2 3.0|
Inflammation, Chronic Active | | 2 2.0|
Metaplasia, Squamous | 2 | 1 2.0|
__________________________________________________________________________|____________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Cyst | 3 3 | 5 2.8|
__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Lymph Node | + + +| 5 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
NTP Experiment-Test: 05180-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC GALLIUM ARSENIDE Date: 02/17/99
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:17:39
__________________________________________________________________________________________________________________________________
| 3| 2| 7| 6| 7| 4| 6| 2| 6| 6| 7| 5| 4| 5| 5| 4| 7| 7| 6| 7| 7| 7| 6| 5| 7| |
DAY ON TEST | 1| 5| 1| 7| 3| 1| 9| 1| 7| 8| 3| 6| 7| 1| 0| 7| 3| 3| 9| 0| 3| 3| 8| 9| 1| |
| 0| 4| 2| 4| 4| 8| 1| 5| 7| 4| 4| 4| 8| 9| 6| 6| 4| 5| 6| 3| 4| 5| 8| 4| 6| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| A |
1.0 | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
MG/M3 | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
Renal, Hemorrhage | 2| 1 2.0|
__________________________________________________________________________|____________|
Lymph Node, Bronchial | M M + + + + M + + + M + + + + + M M + M M + + + +| 40 |
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + M + M + + + + + + + + + + + + + + + + M + + +| 47 |
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Lymph Node, Mediastinal | + M + + + + + M + + + + + + + + M M M + M M + + +| 39 |
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Fibrosis | | 1 2.0|
Hematopoietic Cell Proliferation | 3 | 1 3.0|
Hemorrhage | | 2 2.5|
__________________________________________________________________________|____________|
Thymus | + + + + + + + + + + + + + + + + + + + + + + + + +| 45 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Fibrous Osteodystrophy | 3 | 2 3.5|
Hyperostosis | 4 3 2 1 3 2 | 9 2.6|
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Hyperplasia | | 1 1.0|
Inflammation, Chronic Active | | 3 1.7|
Metaplasia, Squamous | 1 1 1 1 3 | 11 1.5|
Epiglottis, Hyperplasia | 2 | 3 1.7|
Epiglottis, Metaplasia, Squamous | 3 | 3 2.3|
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia, Atypical | 3 1 2 2 2 1 2 3 3 2 2| 16 2.2|
Inflammation, Chronic Active | 4 4 4 4 4 4 4 2 4 4 4 4 4 4 3 4 4 4 4 4 4 4 4 4 4| 50 3.7|
Metaplasia, Squamous | | 1 2.0|
Mineralization | | 1 4.0|
Proteinosis | 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4| 49 3.8|
Alveolar Epithelium, Hyperplasia | 3 1 2 1 2 2 2 3 | 14 2.3|
Alveolar Epithelium, Metaplasia | 2 3 2 3 3 3 3 2 2 3 4 3 3 3 4 3 3 3| 41 2.6|
Artery, Mediastinum, Mineralization | | 1 4.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
NTP Experiment-Test: 05180-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC GALLIUM ARSENIDE Date: 02/17/99
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:17:39
__________________________________________________________________________________________________________________________________
| 3| 2| 7| 6| 7| 4| 6| 2| 6| 6| 7| 5| 4| 5| 5| 4| 7| 7| 6| 7| 7| 7| 6| 5| 7| |
DAY ON TEST | 1| 5| 1| 7| 3| 1| 9| 1| 7| 8| 3| 6| 7| 1| 0| 7| 3| 3| 9| 0| 3| 3| 8| 9| 1| |
| 0| 4| 2| 4| 4| 8| 1| 5| 7| 4| 4| 4| 8| 9| 6| 6| 4| 5| 6| 3| 4| 5| 8| 4| 6| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| A |
1.0 | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
MG/M3 | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Inflammation, Suppurative | 2 2| 3 2.0|
Thrombosis | 2 1 4 | 6 2.7|
Olfactory Epithelium, Atrophy | | 2 1.5|
Olfactory Epithelium, Degeneration, | | |
Hyaline | 1 2 1 2 2 2 1 2 2 2 2 1 2 1 2 | 32 1.6|
Olfactory Epithelium, Metaplasia, | | |
Respiratory | | 1 3.0|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Mineralization | | 1 3.0|
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Ear | + | 1 |
__________________________________________________________________________|____________|
Eye | | 1 |
Cataract | | 1 3.0|
Retina, Atrophy | | 1 3.0|
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Angiectasis | 4 | 1 4.0|
Infarct | | 1 2.0|
Mineralization | | 1 3.0|
Nephropathy | 1 2 2 4 2 4 1 4 2 3 3 1 1 1 3 3 2 2 3 2 3 2 2| 45 2.4|
Thrombosis | 4 | 1 4.0|
Renal Tubule, Hyperplasia | 2 | 2 1.5|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + M + + + + + + + + + + + +| 49 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
NTP Experiment-Test: 05180-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC GALLIUM ARSENIDE Date: 02/17/99
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:17:39
_____________________________________________________________________________________________________________________
| 6| 6| 7| 7| 5| 7| 5| 7| 5| 7| 6| 6| 6| 5| 7| 6| 6| 6| 6| 7| 7| 7| 3| 5| 5|
DAY ON TEST | 4| 8| 3| 3| 6| 3| 3| 3| 9| 2| 8| 6| 1| 0| 3| 4| 6| 7| 8| 3| 3| 3| 3| 6| 9|
| 2| 1| 3| 3| 6| 3| 4| 3| 0| 6| 8| 2| 2| 6| 3| 5| 2| 1| 5| 3| 3| 3| 8| 7| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
CONTROL | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Acute | 1 |
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Acute | |
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + A + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + A + + + + + + + + + + + A|
Inflammation, Granulomatous | |
Mineralization | |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | X X X X X X X X X X X X X X X |
Clear Cell Focus | X X X X |
Degeneration, Cystic | 2 2 2 2|
Eosinophilic Focus | X X X |
Fatty Change | 1 |
Hepatodiaphragmatic Nodule | |
Inflammation, Granulomatous | |
Mixed Cell Focus | X |
Necrosis | 1 |
Regeneration | |
Vacuolization Cytoplasmic, Focal | 3 |
Bile Duct, Hyperplasia | 2 2 2 1 1 2 2 1 1 3 2 2 |
Centrilobular, Necrosis | 2 1 1 1 2 2 1 3|
__________________________________________________________________________|
Mesentery | |
Artery, Mineralization | |
Fat, Necrosis | |
__________________________________________________________________________|
Oral Mucosa | + |
Pharyngeal, Inflammation, Chronic | 3 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 2 2 3 2 2 1 3 1 1 3 2 2 2 |
Basophilic Focus | X X X |
Hyperplasia | 2 |
Artery, Inflammation | |
Artery, Mineralization | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 2 |
Artery, Mineralization | |
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mineralization | |
Necrosis | 4 2 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Acute | |
_____________________________________________________________________________________________________________________|
NTP Experiment-Test: 05180-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC GALLIUM ARSENIDE Date: 02/17/99
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:17:39
_____________________________________________________________________________________________________________________
| 6| 6| 7| 7| 5| 7| 5| 7| 5| 7| 6| 6| 6| 5| 7| 6| 6| 6| 6| 7| 7| 7| 3| 5| 5|
DAY ON TEST | 4| 8| 3| 3| 6| 3| 3| 3| 9| 2| 8| 6| 1| 0| 3| 4| 6| 7| 8| 3| 3| 3| 3| 6| 9|
| 2| 1| 3| 3| 6| 3| 4| 3| 0| 6| 8| 2| 2| 6| 3| 5| 2| 1| 5| 3| 3| 3| 8| 7| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
CONTROL | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
Mineralization | 1 1 |
Necrosis | 1 |
__________________________________________________________________________|
Tongue | + + |
__________________________________________________________________________|
Tooth | + |
Developmental Malformation | X |
Inflammation, Chronic Active | 3 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | |
Aorta, Mineralization | |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | 1 2 2 2 2 2 2 2 2 3 2 2 1 2 3 3 2 3 2 1 3|
Artery, Mineralization | |
Atrium, Thrombosis | 3 4|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | |
Hyperplasia | 2 2 2 2 2 2 2 1 1 2 2 2 2 2 2 2 |
Hypertrophy | 2 |
Necrosis | 2 |
Vacuolization Cytoplasmic | |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 2 1 2 2 3 2 4 3 3 3 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + A + + + + + + + + + + + +|
Hyperplasia | |
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + I + + + + + + + + + + + + + +|
Hyperplasia | 3 2 |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Hyperplasia | 4 3 2 3 2 4 3 3 2 3 3|
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + A + + + + + + + + + + + A|
Hyperplasia | 3 |
C-Cell, Hyperplasia | 1 2 1 2 1 3 1 1 3 1 3 2 1 2 1 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Peritoneum | +|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Penis | + |
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | |
Inflammation, Chronic Active | 2 |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NTP Experiment-Test: 05180-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC GALLIUM ARSENIDE Date: 02/17/99
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:17:39
_____________________________________________________________________________________________________________________
| 6| 6| 7| 7| 5| 7| 5| 7| 5| 7| 6| 6| 6| 5| 7| 6| 6| 6| 6| 7| 7| 7| 3| 5| 5|
DAY ON TEST | 4| 8| 3| 3| 6| 3| 3| 3| 9| 2| 8| 6| 1| 0| 3| 4| 6| 7| 8| 3| 3| 3| 3| 6| 9|
| 2| 1| 3| 3| 6| 3| 4| 3| 0| 6| 8| 2| 2| 6| 3| 5| 2| 1| 5| 3| 3| 3| 8| 7| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
CONTROL | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
Hyperplasia | 2 3 3 1 2 1 2 4 |
Inflammation, Chronic Active | |
Mineralization | |
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + A + + + + + + + + + + + +|
Mineralization | |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | |
Artery, Inflammation, Chronic Active | |
Interstitial Cell, Hyperplasia | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node | + + + + + |
Hemorrhage | 2 |
Renal, Ectasia | 2 |
Renal, Hemorrhage | |
__________________________________________________________________________|
Lymph Node, Bronchial | M + + + + M + + + + + + + + M M M M M M + + + + M|
__________________________________________________________________________|
Lymph Node, Mandibular | + + + M + + + + + + + + + + + + + + M + + + + + +|
Infiltration Cellular, Plasma Cell | 4 4 |
Infiltration Cellular, | |
Polymorphonuclear | |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | |
__________________________________________________________________________|
Lymph Node, Mediastinal | + + M M + M + + M + + + + + + + + M + M + + + + +|
Hemorrhage | 2 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | 3 |
Fibrosis | 2 2 2 3 2 2 2 2 2 |
Hematopoietic Cell Proliferation | 2 2 3|
Inflammation, Granulomatous | 2 4 |
Thrombosis | 3 |
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + M + + + + M + + + + + + +|
Cyst | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + M + M + M + + + + + + + + + M M + M + + + + + +|
Galactocele | |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperkeratosis | 3 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrous Osteodystrophy | 3 |
__________________________________________________________________________|
Skeletal Muscle | + |
_____________________________________________________________________________________________________________________|
NTP Experiment-Test: 05180-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC GALLIUM ARSENIDE Date: 02/17/99
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:17:39
_____________________________________________________________________________________________________________________
| 6| 6| 7| 7| 5| 7| 5| 7| 5| 7| 6| 6| 6| 5| 7| 6| 6| 6| 6| 7| 7| 7| 3| 5| 5|
DAY ON TEST | 4| 8| 3| 3| 6| 3| 3| 3| 9| 2| 8| 6| 1| 0| 3| 4| 6| 7| 8| 3| 3| 3| 3| 6| 9|
| 2| 1| 3| 3| 6| 3| 4| 3| 0| 6| 8| 2| 2| 6| 3| 5| 2| 1| 5| 3| 3| 3| 8| 7| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
CONTROL | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM - cont | |
| |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Degeneration | 2 |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 |
Inflammation, Chronic Active | 2 |
Metaplasia, Squamous | |
Mineralization | |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | |
Inflammation, Chronic Active | 1 1 |
Mineralization | |
Thrombosis | |
Alveolar Epithelium, Hyperplasia | 1 1 3 1 2 4 3 4 |
Artery, Mediastinum, Mineralization | |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Suppurative | 2 2 1 |
Thrombosis | 3 3 4|
Olfactory Epithelium, Atrophy | 1 |
Olfactory Epithelium, Degeneration, | |
Hyaline | 1 2 1 2 2 1 2 1 1 |
Olfactory Epithelium, Metaplasia, | |
Respiratory | 2 1 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mineralization | |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | + |
__________________________________________________________________________|
Eye | + + + |
Cataract | 3 4 4 |
Retina, Atrophy | 3 4 4 |
__________________________________________________________________________|
Zymbal's Gland | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | |
Mineralization | |
Nephropathy | 2 2 3 3 2 3 4 3 4 3 4 3 2 2 2 2 3 4 4 3 4 3 2 3 3|
Renal Tubule, Hyperplasia | 2 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | |
Transitional Epithelium, Hyperplasia | |
_____________________________________________________________________________________________________________________|
Page 37
NTP Experiment-Test: 05180-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC GALLIUM ARSENIDE Date: 02/17/99
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:17:39
__________________________________________________________________________________________________________________________________
| 7| 6| 6| 6| 7| 7| 6| 6| 5| 6| 6| 7| 7| 7| 6| 6| 7| 7| 5| 5| 5| 6| 6| 5| 5| |
DAY ON TEST | 3| 5| 1| 3| 3| 2| 1| 4| 6| 7| 2| 3| 3| 3| 2| 9| 1| 2| 9| 6| 4| 8| 8| 4| 3| |
| 3| 8| 7| 6| 3| 0| 2| 7| 6| 7| 1| 3| 3| 3| 1| 3| 3| 9| 0| 7| 5| 5| 4| 4| 4| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| A |
CONTROL | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + A + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + A + + A + + + + + + + + + + + + + + + A + +| 47 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + A + + + + + + + + + + + + + + + A + +| 48 |
Inflammation, Acute | | 1 1.0|
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + A + + A + + + + + + + + + + + + + A + A + +| 46 |
Inflammation, Acute | 3 | 1 3.0|
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + A + + + + + + + + + + + + + + + A + +| 48 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + A + + + + A + + + + + + + + + + + + + A + A + +| 45 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + A + + + + A + + + + + + + + + + + + + A + A + +| 44 |
Inflammation, Granulomatous | 2 | 1 2.0|
Mineralization | 2 | 1 2.0|
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Basophilic Focus | X X X X X X| 21 |
Clear Cell Focus | X X | 6 |
Degeneration, Cystic | 2 2 4 2 1 2 | 10 2.1|
Eosinophilic Focus | X X X | 6 |
Fatty Change | 2 1 2 3 | 5 1.8|
Hepatodiaphragmatic Nodule | X | 1 |
Inflammation, Granulomatous | 1 | 1 1.0|
Mixed Cell Focus | | 1 |
Necrosis | 3 | 2 2.0|
Regeneration | 3 | 1 3.0|
Vacuolization Cytoplasmic, Focal | | 1 3.0|
Bile Duct, Hyperplasia | 1 3 1 3 1 1 2 1 4 2 3 1 1 2 1 2| 28 1.8|
Centrilobular, Necrosis | 2 1 1 1 2| 13 1.5|
__________________________________________________________________________|____________|
Mesentery | + + + + + | 5 |
Artery, Mineralization | 3 4 4 | 3 3.7|
Fat, Necrosis | 3 2 2 | 3 2.3|
__________________________________________________________________________|____________|
Oral Mucosa | | 1 |
Pharyngeal, Inflammation, Chronic | | 1 3.0|
__________________________________________________________________________|____________|
Pancreas | + + + + + + A + + + + + + + + + + + + + + + + + +| 49 |
Atrophy | 2 2 2 1 1 1 2 2 1 3 1 | 24 1.8|
Basophilic Focus | | 3 |
Hyperplasia | 3 2 2 | 4 2.3|
Artery, Inflammation | 4 4 | 2 4.0|
Artery, Mineralization | 4 2 3 | 3 3.0|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Atrophy | | 1 2.0|
Artery, Mineralization | 2 | 1 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
NTP Experiment-Test: 05180-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC GALLIUM ARSENIDE Date: 02/17/99
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:17:39
__________________________________________________________________________________________________________________________________
| 7| 6| 6| 6| 7| 7| 6| 6| 5| 6| 6| 7| 7| 7| 6| 6| 7| 7| 5| 5| 5| 6| 6| 5| 5| |
DAY ON TEST | 3| 5| 1| 3| 3| 2| 1| 4| 6| 7| 2| 3| 3| 3| 2| 9| 1| 2| 9| 6| 4| 8| 8| 4| 3| |
| 3| 8| 7| 6| 3| 0| 2| 7| 6| 7| 1| 3| 3| 3| 1| 3| 3| 9| 0| 7| 5| 5| 4| 4| 4| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| A |
CONTROL | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + A + + + + + + + + + + + + + + + + + +| 49 |
Mineralization | 3 4 | 2 3.5|
Necrosis | 2 2 4 4 4 | 7 3.1|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + A + + + + + + + + + + + + + + + + + +| 49 |
Inflammation, Acute | 3 | 1 3.0|
Mineralization | 3 4 1 2 3 4 | 8 2.4|
Necrosis | 2 3 3| 4 2.3|
__________________________________________________________________________|____________|
Tongue | | 2 |
__________________________________________________________________________|____________|
Tooth | + | 2 |
Developmental Malformation | X | 2 |
Inflammation, Chronic Active | | 1 3.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood Vessel | + + + | 3 |
Aorta, Mineralization | 4 3 4 | 3 3.7|
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cardiomyopathy | 2 2 1 3 1 4 3 4 2 1 2 2 2 2 2 2 3 3 4 2 3 4 2 | 44 2.3|
Artery, Mineralization | 4 4 1 3 4 | 5 3.2|
Atrium, Thrombosis | 3 3 | 4 3.3|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + A + + + + + + + + + + + + + + + + + +| 49 |
Atrophy | 3 | 1 3.0|
Hyperplasia | 2 2 2 2 2 2 2 2 | 24 1.9|
Hypertrophy | | 1 2.0|
Necrosis | | 1 2.0|
Vacuolization Cytoplasmic | 4 2 | 2 3.0|
__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | 3 1 1 3 3 3 3 2 3 1 4 | 22 2.5|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + A + + + + + + + + + + + + + + + + + +| 48 |
Hyperplasia | 2 | 1 2.0|
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + + + M + + + + M + + + + + + + + + + +| 47 |
Hyperplasia | 2 4 4 2 2 3 1 3 3 4 2 | 13 2.7|
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + A + +| 49 |
Pars Distalis, Hyperplasia | 4 2 2 1 3 1 | 17 2.6|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + A + + + + + + + + + + + + + + + A + +| 46 |
Hyperplasia | | 1 3.0|
C-Cell, Hyperplasia | 1 1 1 1 1 1 1 1 1 2 1 | 26 1.4|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
NTP Experiment-Test: 05180-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC GALLIUM ARSENIDE Date: 02/17/99
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:17:39
__________________________________________________________________________________________________________________________________
| 7| 6| 6| 6| 7| 7| 6| 6| 5| 6| 6| 7| 7| 7| 6| 6| 7| 7| 5| 5| 5| 6| 6| 5| 5| |
DAY ON TEST | 3| 5| 1| 3| 3| 2| 1| 4| 6| 7| 2| 3| 3| 3| 2| 9| 1| 2| 9| 6| 4| 8| 8| 4| 3| |
| 3| 8| 7| 6| 3| 0| 2| 7| 6| 7| 1| 3| 3| 3| 1| 3| 3| 9| 0| 7| 5| 5| 4| 4| 4| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| A |
CONTROL | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM - cont | | |
| | |
| | |
__________________________________________________________________________|____________|
Peritoneum | | 1 |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Penis | | 1 |
__________________________________________________________________________|____________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | 1 | 1 1.0|
Inflammation, Chronic Active | 4 3 4 | 4 3.3|
__________________________________________________________________________|____________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | 2 2 2 3 | 12 2.3|
Inflammation, Chronic Active | 2 3 2 | 3 2.3|
Mineralization | 3 | 1 3.0|
__________________________________________________________________________|____________|
Seminal Vesicle | + A + + + + A + + + + + + + + + + + + + A + A + +| 45 |
Mineralization | 3 2 | 2 2.5|
__________________________________________________________________________|____________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Atrophy | 3 | 1 3.0|
Artery, Inflammation, Chronic Active | 3 3 2 | 3 2.7|
Interstitial Cell, Hyperplasia | 1 2 | 2 1.5|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + A + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Lymph Node | + + + + + + +| 12 |
Hemorrhage | | 1 2.0|
Renal, Ectasia | | 1 2.0|
Renal, Hemorrhage | 1 | 1 1.0|
__________________________________________________________________________|____________|
Lymph Node, Bronchial | + + + + M + M + M + + + + + + + + + M + + + M + +| 36 |
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + M + + + + + + + + + M + + + + + +| 46 |
Infiltration Cellular, Plasma Cell | | 2 4.0|
Infiltration Cellular, | | |
Polymorphonuclear | 2 | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + A + + + + + + + + + + + + + + + A + +| 48 |
Hemorrhage | 2 | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node, Mediastinal | + + M + + + + + + + + + + + + + + + M + + + + + +| 42 |
Hemorrhage | | 1 2.0|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Congestion | | 1 3.0|
Fibrosis | 2 2 3 2| 13 2.2|
Hematopoietic Cell Proliferation | 3 | 4 2.5|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
NTP Experiment-Test: 05180-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC GALLIUM ARSENIDE Date: 02/17/99
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:17:39
__________________________________________________________________________________________________________________________________
| 7| 6| 6| 6| 7| 7| 6| 6| 5| 6| 6| 7| 7| 7| 6| 6| 7| 7| 5| 5| 5| 6| 6| 5| 5| |
DAY ON TEST | 3| 5| 1| 3| 3| 2| 1| 4| 6| 7| 2| 3| 3| 3| 2| 9| 1| 2| 9| 6| 4| 8| 8| 4| 3| |
| 3| 8| 7| 6| 3| 0| 2| 7| 6| 7| 1| 3| 3| 3| 1| 3| 3| 9| 0| 7| 5| 5| 4| 4| 4| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| A |
CONTROL | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
Inflammation, Granulomatous | | 2 3.0|
Thrombosis | | 1 3.0|
__________________________________________________________________________|____________|
Thymus | + + + + + + + M + + + + + + + + + + + + + + M + +| 46 |
Cyst | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + M + + + + + + + + M + + + + + + + + + M + + + +| 41 |
Galactocele | 3 | 1 3.0|
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperkeratosis | | 1 3.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Fibrous Osteodystrophy | 2 4 4 1 2 4 4 | 8 3.0|
__________________________________________________________________________|____________|
Skeletal Muscle | | 1 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Degeneration | | 1 2.0|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | 2 2 | 3 2.0|
Inflammation, Chronic Active | 1 1 2 | 4 1.5|
Metaplasia, Squamous | 2 | 1 2.0|
Mineralization | 2 | 1 2.0|
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hemorrhage | 2 | 1 2.0|
Inflammation, Chronic Active | 1 | 3 1.0|
Mineralization | 3 4 3 3 | 4 3.3|
Thrombosis | 2 | 1 2.0|
Alveolar Epithelium, Hyperplasia | 1 1 1 2 | 12 2.0|
Artery, Mediastinum, Mineralization | 4 4 3 4 | 4 3.8|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Suppurative | 4 2 2 2 1 3 3 | 10 2.2|
Thrombosis | 4 | 4 3.5|
Olfactory Epithelium, Atrophy | | 1 1.0|
Olfactory Epithelium, Degeneration, | | |
Hyaline | 1 1 2 1 1 1 1 2 2| 18 1.4|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
NTP Experiment-Test: 05180-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC GALLIUM ARSENIDE Date: 02/17/99
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:17:39
__________________________________________________________________________________________________________________________________
| 7| 6| 6| 6| 7| 7| 6| 6| 5| 6| 6| 7| 7| 7| 6| 6| 7| 7| 5| 5| 5| 6| 6| 5| 5| |
DAY ON TEST | 3| 5| 1| 3| 3| 2| 1| 4| 6| 7| 2| 3| 3| 3| 2| 9| 1| 2| 9| 6| 4| 8| 8| 4| 3| |
| 3| 8| 7| 6| 3| 0| 2| 7| 6| 7| 1| 3| 3| 3| 1| 3| 3| 9| 0| 7| 5| 5| 4| 4| 4| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| A |
CONTROL | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont | | |
| | |
Olfactory Epithelium, Metaplasia, | | |
Respiratory | | 2 1.5|
__________________________________________________________________________|____________|
Trachea | + + + + + + A + + + + + + + + + + + + + + + + + +| 49 |
Mineralization | 2 3 | 2 2.5|
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Ear | | 1 |
__________________________________________________________________________|____________|
Eye | + | 4 |
Cataract | 4 | 4 3.8|
Retina, Atrophy | 3 | 4 3.5|
__________________________________________________________________________|____________|
Zymbal's Gland | + | 1 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + A + + + + + + + + + + + + + + + + + +| 49 |
Cyst | 2 2 2 | 3 2.0|
Mineralization | 3 3 1 3 3 | 5 2.6|
Nephropathy | 3 2 4 2 4 4 4 2 4 3 4 3 4 4 3 4 4 4 2 2 3 4 3 | 48 3.1|
Renal Tubule, Hyperplasia | 3 | 2 2.5|
__________________________________________________________________________|____________|
Urinary Bladder | + A + + + + A + + + + + + + + + + + + + + + + + +| 48 |
Inflammation, Chronic Active | 3 | 1 3.0|
Transitional Epithelium, Hyperplasia | 4 | 1 4.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
NTP Experiment-Test: 05180-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC GALLIUM ARSENIDE Date: 02/17/99
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:17:39
_____________________________________________________________________________________________________________________
| 3| 5| 7| 7| 6| 6| 7| 7| 6| 7| 5| 5| 7| 7| 5| 6| 5| 6| 5| 6| 2| 7| 6| 5| 3|
DAY ON TEST | 5| 7| 0| 3| 2| 6| 1| 0| 4| 3| 3| 8| 3| 3| 4| 4| 9| 8| 6| 1| 0| 3| 9| 3| 9|
| 0| 4| 9| 3| 1| 0| 2| 8| 7| 3| 2| 6| 3| 3| 8| 7| 0| 4| 6| 4| 4| 3| 1| 4| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
0.01 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
MG/M3 | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + A + + + + + + + + A + + + +|
Mineralization | 2 |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mineralization | 2 |
__________________________________________________________________________|
Intestine Large, Cecum | A + + + + + + + + + + A + + + + + + + + A + + + +|
Inflammation, Acute | |
Mineralization | 2 2 |
Necrosis | 2 |
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Acute | |
__________________________________________________________________________|
Intestine Small, Jejunum | A + + + + + + + + + + A + + + + + + + + A + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | A + + + + + + + + + + A + + + + + + + + A + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 3 2 |
Basophilic Focus | X X X X X X X X X X |
Clear Cell Focus | X X |
Degeneration, Cystic | 2 1 1 2 4 |
Eosinophilic Focus | X X |
Fatty Change | 2 1 2 |
Hepatodiaphragmatic Nodule | |
Regeneration | 2 4 4 |
Bile Duct, Hyperplasia | 2 3 1 1 3 2 3 1 3 3 2 3 2 |
Centrilobular, Necrosis | 1 1 2 3 2 2 1 3 1|
__________________________________________________________________________|
Mesentery | + + + + +|
Hemorrhage | 4|
Artery, Inflammation, Chronic Active | |
Artery, Mineralization | 3 4 |
Fat, Necrosis | 2 2 3 |
__________________________________________________________________________|
Oral Mucosa | + + |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 2 2 1 2 2 2 3 2 2 1 1 2 1 |
Basophilic Focus | X X |
Hyperplasia | 2 4 2 |
Artery, Mineralization | 3 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mineralization | 2 2 |
Necrosis | 1 3 4 3 2 3 2|
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mineralization | 2 3 4 2 |
Necrosis | 1 3 3 2 2 1|
__________________________________________________________________________|
Tooth | |
Developmental Malformation | |
_____________________________________________________________________________________________________________________|
NTP Experiment-Test: 05180-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC GALLIUM ARSENIDE Date: 02/17/99
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:17:39
_____________________________________________________________________________________________________________________
| 3| 5| 7| 7| 6| 6| 7| 7| 6| 7| 5| 5| 7| 7| 5| 6| 5| 6| 5| 6| 2| 7| 6| 5| 3|
DAY ON TEST | 5| 7| 0| 3| 2| 6| 1| 0| 4| 3| 3| 8| 3| 3| 4| 4| 9| 8| 6| 1| 0| 3| 9| 3| 9|
| 0| 4| 9| 3| 1| 0| 2| 8| 7| 3| 2| 6| 3| 3| 8| 7| 0| 4| 6| 4| 4| 3| 1| 4| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
0.01 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
MG/M3 | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | + + |
Aorta, Mineralization | 3 4 |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | 1 3 1 3 2 3 2 3 2 2 2 2 2 2 1 |
Artery, Mineralization | 3 4 |
Atrium, Thrombosis | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 2 2 2 2 2 2 2 2 2 2 2 |
Hypertrophy | |
Mineralization | |
Vacuolization Cytoplasmic | 2 3 2|
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 3 2 2 4 2 3 3 3 3 3 2 3 2 3 |
Bilateral, Hyperplasia | |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 3 |
__________________________________________________________________________|
Parathyroid Gland | + + + + + + M + + + + + + + + + + + + + + + + + +|
Hyperplasia | 3 4 3 1 3 2 2 |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | |
Pars Distalis, Hyperplasia | 4 2 1 2 3 |
__________________________________________________________________________|
Thyroid Gland | A + + + + + + + + + + A + + + + + + + + + + + + +|
C-Cell, Hyperplasia | 1 1 1 1 1 2 1 2 1 1 2 1 1 1 |
Follicular Cell, Hyperplasia | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Coagulating Gland | + |
Hyperplasia, Atypical | 3 |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Preputial Gland | + + M + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + A + + + +|
Hyperplasia | 2 3 1 |
Inflammation, Chronic Active | 4 |
__________________________________________________________________________|
Seminal Vesicle | A + + + + + + + + + + + + + + + + + + + + + + + +|
Mineralization | 2 |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NTP Experiment-Test: 05180-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC GALLIUM ARSENIDE Date: 02/17/99
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:17:39
_____________________________________________________________________________________________________________________
| 3| 5| 7| 7| 6| 6| 7| 7| 6| 7| 5| 5| 7| 7| 5| 6| 5| 6| 5| 6| 2| 7| 6| 5| 3|
DAY ON TEST | 5| 7| 0| 3| 2| 6| 1| 0| 4| 3| 3| 8| 3| 3| 4| 4| 9| 8| 6| 1| 0| 3| 9| 3| 9|
| 0| 4| 9| 3| 1| 0| 2| 8| 7| 3| 2| 6| 3| 3| 8| 7| 0| 4| 6| 4| 4| 3| 1| 4| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
0.01 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
MG/M3 | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
Atrophy | |
Artery, Inflammation, Chronic Active | 3 2 |
Interstitial Cell, Hyperplasia | 2 2|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node | + + + + +|
Renal, Infiltration Cellular, Plasma | |
Cell | |
__________________________________________________________________________|
Lymph Node, Bronchial | M + + + M + + + + M + + + + + M + M + + + M + + +|
__________________________________________________________________________|
Lymph Node, Mandibular | M + + + + + + + + + + + + M + M + + + + + + + + +|
Infiltration Cellular, Plasma Cell | |
__________________________________________________________________________|
Lymph Node, Mesenteric | M + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node, Mediastinal | M + + + + + + + + + + + M + + M M + + + + M + + +|
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrosis | 2 2 2 2 2 2 |
Hematopoietic Cell Proliferation | 3 |
Hyperplasia | |
Necrosis | |
__________________________________________________________________________|
Thymus | + + M + + + + + + M + + + + + + + + M + + + + + +|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | A + + M + + + + + + + + + + + + + + + M + M + + +|
Galactocele | 2 |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + I + + + + + +|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Callus | 4 |
Fibrous Osteodystrophy | 3 3 4 2 1 |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Gliosis | |
__________________________________________________________________________|
Peripheral Nerve | + |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 1 1 1 1 |
Inflammation, Chronic Active | 2 1 1 |
Metaplasia, Squamous | 1 |
Epiglottis, Hyperplasia | 2 1 1 1 |
Epiglottis, Inflammation, Chronic | |
Active | 2 |
_____________________________________________________________________________________________________________________|
NTP Experiment-Test: 05180-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC GALLIUM ARSENIDE Date: 02/17/99
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:17:39
_____________________________________________________________________________________________________________________
| 3| 5| 7| 7| 6| 6| 7| 7| 6| 7| 5| 5| 7| 7| 5| 6| 5| 6| 5| 6| 2| 7| 6| 5| 3|
DAY ON TEST | 5| 7| 0| 3| 2| 6| 1| 0| 4| 3| 3| 8| 3| 3| 4| 4| 9| 8| 6| 1| 0| 3| 9| 3| 9|
| 0| 4| 9| 3| 1| 0| 2| 8| 7| 3| 2| 6| 3| 3| 8| 7| 0| 4| 6| 4| 4| 3| 1| 4| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
0.01 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
MG/M3 | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | |
Hyperplasia, Atypical | 1 4 |
Inflammation, Chronic Active | 1 2 2 2 1 2 1 2 2 1 2 1 2 1 2 1 1 2 1 2 1|
Mineralization | 3 3 4 |
Proteinosis | 1 1 1 1 1 1 1 1 1|
Alveolar Epithelium, Hyperplasia | 2 3 1 1 1 1 |
Alveolar Epithelium, Metaplasia | 1 1 |
Artery, Mediastinum, Mineralization | 4 4 |
__________________________________________________________________________|
Nose | A + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Suppurative | 2 2 |
Thrombosis | 3 2 4 2 3 2 |
Olfactory Epithelium, Atrophy | 1 |
Olfactory Epithelium, Degeneration, | |
Hyaline | 1 2 2 1 1 1 1 2 1 1 |
Olfactory Epithelium, Metaplasia, | |
Respiratory | 1 |
__________________________________________________________________________|
Pleura | + |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + |
Cataract | 4 |
Retina, Atrophy | 4 |
__________________________________________________________________________|
Zymbal's Gland | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | 2 2 |
Infarct | 2 2 |
Mineralization | 2 4 |
Nephropathy | 2 2 3 4 4 4 3 4 4 4 2 2 4 3 2 4 3 3 2 4 4 3 3 2|
Renal Tubule, Hyperplasia | 2 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | 4 |
_____________________________________________________________________________________________________________________|
NTP Experiment-Test: 05180-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC GALLIUM ARSENIDE Date: 02/17/99
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:17:39
__________________________________________________________________________________________________________________________________
| 5| 3| 6| 5| 5| 5| 5| 7| 6| 7| 6| 6| 7| 7| 7| 6| 7| 7| 7| 7| 5| 7| 6| 6| 6| |
DAY ON TEST | 6| 0| 0| 2| 4| 9| 9| 3| 0| 3| 2| 2| 3| 1| 0| 5| 3| 3| 3| 3| 8| 3| 4| 9| 4| |
| 7| 6| 0| 4| 8| 0| 4| 3| 1| 3| 1| 5| 3| 9| 1| 5| 3| 3| 3| 3| 7| 3| 2| 9| 7| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| A |
0.01 | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
MG/M3 | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + A + + + + + + + + + + + + + + + + + +| 47 |
Mineralization | | 1 2.0|
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + A + + + + + + + + + + + + + + + + + +| 49 |
Mineralization | | 1 2.0|
__________________________________________________________________________|____________|
Intestine Large, Cecum | + A A + + + A + + + + + + + + + + + + + A + + + +| 43 |
Inflammation, Acute | 4 | 1 4.0|
Mineralization | 3 | 3 2.3|
Necrosis | | 1 2.0|
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + A + + + A + + + + + + + + + + + + + + + + + +| 48 |
Inflammation, Acute | 2 | 1 2.0|
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + A A + + + A + + + + + + + + + + + + + A + + + +| 43 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + A A + + + A + + + + + + + + + + + + + A + + + +| 43 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Angiectasis | | 2 2.5|
Basophilic Focus | X X X X X X X X X X X X X| 23 |
Clear Cell Focus | X | 3 |
Degeneration, Cystic | 2 2 1 2 | 9 1.9|
Eosinophilic Focus | X X | 4 |
Fatty Change | 1 2 3 2 1| 8 1.8|
Hepatodiaphragmatic Nodule | X X | 2 |
Regeneration | 3 | 4 3.3|
Bile Duct, Hyperplasia | 2 2 3 2 2 2 2 1 2 2 1 3 3 2| 27 2.1|
Centrilobular, Necrosis | 3 1 1 2 2 | 14 1.8|
__________________________________________________________________________|____________|
Mesentery | + + + + +| 10 |
Hemorrhage | | 1 4.0|
Artery, Inflammation, Chronic Active | 3 | 1 3.0|
Artery, Mineralization | | 2 3.5|
Fat, Necrosis | 2 2 2 2| 7 2.1|
__________________________________________________________________________|____________|
Oral Mucosa | + | 3 |
__________________________________________________________________________|____________|
Pancreas | + A + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Atrophy | 1 1 1 1 2 1 2 2 1 1 2 1 2 3 3 2| 29 1.7|
Basophilic Focus | X | 3 |
Hyperplasia | | 3 2.7|
Artery, Mineralization | 2 | 2 2.5|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Mineralization | | 2 2.0|
Necrosis | 2 3 3 | 10 2.6|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
NTP Experiment-Test: 05180-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC GALLIUM ARSENIDE Date: 02/17/99
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:17:39
__________________________________________________________________________________________________________________________________
| 5| 3| 6| 5| 5| 5| 5| 7| 6| 7| 6| 6| 7| 7| 7| 6| 7| 7| 7| 7| 5| 7| 6| 6| 6| |
DAY ON TEST | 6| 0| 0| 2| 4| 9| 9| 3| 0| 3| 2| 2| 3| 1| 0| 5| 3| 3| 3| 3| 8| 3| 4| 9| 4| |
| 7| 6| 0| 4| 8| 0| 4| 3| 1| 3| 1| 5| 3| 9| 1| 5| 3| 3| 3| 3| 7| 3| 2| 9| 7| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| A |
0.01 | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
MG/M3 | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Stomach, Glandular | + A + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Mineralization | 3 3 | 6 2.8|
Necrosis | 3 2 1 | 9 2.0|
__________________________________________________________________________|____________|
Tooth | +| 1 |
Developmental Malformation | X| 1 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood Vessel | + + | 4 |
Aorta, Mineralization | 3 3 | 4 3.3|
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cardiomyopathy | 3 2 1 2 1 2 3 2 2 2 2 2 2 3 2 3 3 2 2 2 2 1| 37 2.1|
Artery, Mineralization | 3 4 2 3 | 6 3.2|
Atrium, Thrombosis | 4 | 1 4.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + A + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Hyperplasia | 2 2 2 2 2 2 2 2 2 3 2 2| 24 2.0|
Hypertrophy | 2 2 2 | 3 2.0|
Mineralization | 2 | 1 2.0|
Vacuolization Cytoplasmic | 2 3 | 5 2.4|
__________________________________________________________________________|____________|
Adrenal Medulla | + A + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Hyperplasia | 2 3 2 2 1 1 2 2 2 3 | 25 2.4|
Bilateral, Hyperplasia | 4 | 1 4.0|
__________________________________________________________________________|____________|
Islets, Pancreatic | + A + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Hyperplasia | 2 | 2 2.5|
__________________________________________________________________________|____________|
Parathyroid Gland | M + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
Hyperplasia | 3 3 4 4 2 4 | 13 2.9|
__________________________________________________________________________|____________|
Pituitary Gland | + A + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Angiectasis | 2 | 1 2.0|
Pars Distalis, Hyperplasia | 3 2 3 2 2 2 2 | 12 2.3|
__________________________________________________________________________|____________|
Thyroid Gland | + A A + + + + + + + + + + + + + + + + + + + + + +| 46 |
C-Cell, Hyperplasia | 1 1 1 2 1 1 1 2 2 1 1 1 3 1| 28 1.3|
Follicular Cell, Hyperplasia | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Coagulating Gland | | 1 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
NTP Experiment-Test: 05180-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC GALLIUM ARSENIDE Date: 02/17/99
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:17:39
__________________________________________________________________________________________________________________________________
| 5| 3| 6| 5| 5| 5| 5| 7| 6| 7| 6| 6| 7| 7| 7| 6| 7| 7| 7| 7| 5| 7| 6| 6| 6| |
DAY ON TEST | 6| 0| 0| 2| 4| 9| 9| 3| 0| 3| 2| 2| 3| 1| 0| 5| 3| 3| 3| 3| 8| 3| 4| 9| 4| |
| 7| 6| 0| 4| 8| 0| 4| 3| 1| 3| 1| 5| 3| 9| 1| 5| 3| 3| 3| 3| 7| 3| 2| 9| 7| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| A |
0.01 | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
MG/M3 | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont | | |
| | |
Hyperplasia, Atypical | | 1 3.0|
__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Inflammation, Chronic Active | 3 3 4 4 | 4 3.5|
__________________________________________________________________________|____________|
Prostate | + A + + + + + + + + + + + + + + + + + + + + + + +| 48 |
Hyperplasia | 2 3 1 2 2 3 | 9 2.1|
Inflammation, Chronic Active | | 1 4.0|
__________________________________________________________________________|____________|
Seminal Vesicle | + A + + + + A + + + + + + + + + + + + + + + + + +| 47 |
Mineralization | | 1 2.0|
__________________________________________________________________________|____________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Atrophy | 4 3 | 2 3.5|
Artery, Inflammation, Chronic Active | 2 3 | 4 2.5|
Interstitial Cell, Hyperplasia | 2 | 3 2.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + A A + + + + + + + + + + + + + + + + + + + + + +| 48 |
__________________________________________________________________________|____________|
Lymph Node | A + + + | 8 |
Renal, Infiltration Cellular, Plasma | | |
Cell | 3 | 1 3.0|
__________________________________________________________________________|____________|
Lymph Node, Bronchial | + + + + + + + + M + + M M + M + + M + + M + + M +| 37 |
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + M + + + + + M + + M + + + + + + + + + M + + + +| 43 |
Infiltration Cellular, Plasma Cell | 2 | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + M + + + + +| 48 |
__________________________________________________________________________|____________|
Lymph Node, Mediastinal | + + + + + + + M + + M + M + + + M + + + M + + + +| 40 |
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Fibrosis | 2 3 2 2 2 2| 12 2.1|
Hematopoietic Cell Proliferation | 3 | 2 3.0|
Hyperplasia | 3 | 1 3.0|
Necrosis | 2 | 1 2.0|
__________________________________________________________________________|____________|
Thymus | + + + + + + + + + + + M + + + + + + + + M + + + +| 45 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + M + + + + + + + + + + + + + M + M M + + + + + +| 42 |
Galactocele | 3 | 2 2.5|
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Callus | | 1 4.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
NTP Experiment-Test: 05180-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC GALLIUM ARSENIDE Date: 02/17/99
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:17:39
__________________________________________________________________________________________________________________________________
| 5| 3| 6| 5| 5| 5| 5| 7| 6| 7| 6| 6| 7| 7| 7| 6| 7| 7| 7| 7| 5| 7| 6| 6| 6| |
DAY ON TEST | 6| 0| 0| 2| 4| 9| 9| 3| 0| 3| 2| 2| 3| 1| 0| 5| 3| 3| 3| 3| 8| 3| 4| 9| 4| |
| 7| 6| 0| 4| 8| 0| 4| 3| 1| 3| 1| 5| 3| 9| 1| 5| 3| 3| 3| 3| 7| 3| 2| 9| 7| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| A |
0.01 | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
MG/M3 | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM - cont | | |
| | |
Fibrous Osteodystrophy | 3 3 3 3 | 9 2.8|
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Gliosis | 2 | 1 2.0|
__________________________________________________________________________|____________|
Peripheral Nerve | | 1 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | 1 1 1 1 | 8 1.0|
Inflammation, Chronic Active | | 3 1.3|
Metaplasia, Squamous | 1 | 2 1.0|
Epiglottis, Hyperplasia | 1 1 | 6 1.2|
Epiglottis, Inflammation, Chronic | | |
Active | | 1 2.0|
__________________________________________________________________________|____________|
Lung | + A + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Hemorrhage | 2 | 1 2.0|
Hyperplasia, Atypical | | 2 2.5|
Inflammation, Chronic Active | 1 2 1 2 2 2 2 1 1 1 2 2 2 2 3 2 2 2 1 2 2 1| 43 1.6|
Mineralization | 2 3 | 5 3.0|
Proteinosis | 1 1 1 1 1 1 1 1 1 1 1 1 1 | 22 1.0|
Alveolar Epithelium, Hyperplasia | 3 2 1 1 2 3 2 1 1 1| 16 1.6|
Alveolar Epithelium, Metaplasia | | 2 1.0|
Artery, Mediastinum, Mineralization | 3 | 3 3.7|
__________________________________________________________________________|____________|
Nose | + A + + + + + + + + + + + + + + + + + + + + + + +| 48 |
Inflammation, Suppurative | 2 2 2 | 5 2.0|
Thrombosis | 4 2 | 8 2.8|
Olfactory Epithelium, Atrophy | 2 | 2 1.5|
Olfactory Epithelium, Degeneration, | | |
Hyaline | 2 2 1 1 1 1 2 1 2 1 2 1 1 1 2 1| 26 1.3|
Olfactory Epithelium, Metaplasia, | | |
Respiratory | 2 | 2 1.5|
__________________________________________________________________________|____________|
Pleura | | 1 |
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | + | 2 |
Cataract | | 1 4.0|
Retina, Atrophy | | 1 4.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
NTP Experiment-Test: 05180-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC GALLIUM ARSENIDE Date: 02/17/99
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:17:39
__________________________________________________________________________________________________________________________________
| 5| 3| 6| 5| 5| 5| 5| 7| 6| 7| 6| 6| 7| 7| 7| 6| 7| 7| 7| 7| 5| 7| 6| 6| 6| |
DAY ON TEST | 6| 0| 0| 2| 4| 9| 9| 3| 0| 3| 2| 2| 3| 1| 0| 5| 3| 3| 3| 3| 8| 3| 4| 9| 4| |
| 7| 6| 0| 4| 8| 0| 4| 3| 1| 3| 1| 5| 3| 9| 1| 5| 3| 3| 3| 3| 7| 3| 2| 9| 7| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| A |
0.01 | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
MG/M3 | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Zymbal's Gland | +| 1 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cyst | 2 | 3 2.0|
Infarct | | 2 2.0|
Mineralization | 2 2 | 4 2.5|
Nephropathy | 1 4 2 2 2 2 4 4 4 3 3 2 3 2 4 4 3 3 4 4 2 3 2 3 3| 49 3.0|
Renal Tubule, Hyperplasia | | 1 2.0|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hemorrhage | 2 | 2 3.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
NTP Experiment-Test: 05180-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC GALLIUM ARSENIDE Date: 02/17/99
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:17:39
_____________________________________________________________________________________________________________________
| 6| 7| 7| 6| 7| 6| 7| 6| 7| 6| 7| 7| 6| 7| 7| 6| 6| 4| 5| 6| 6| 6| 6| 6| 6|
DAY ON TEST | 2| 3| 3| 0| 3| 7| 3| 0| 3| 9| 0| 3| 2| 3| 2| 7| 6| 4| 6| 1| 7| 5| 9| 4| 7|
| 7| 3| 3| 4| 3| 4| 3| 1| 3| 8| 4| 3| 7| 3| 0| 4| 0| 3| 6| 7| 8| 4| 8| 2| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
0.1 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
MG/M3 | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + A + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + I + + + + I + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + A + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + A + + + + + +|
Necrosis | 1 |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + A + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + A + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | X X X X X X X X X|
Clear Cell Focus | X X X X |
Degeneration, Cystic | 2 1 2 1 2 1 |
Eosinophilic Focus | X |
Fatty Change | 2 1 2 2 1 3 |
Hepatodiaphragmatic Nodule | X X |
Mineralization | 2 |
Necrosis | 4 2 2|
Regeneration | 2 4 |
Bile Duct, Hyperplasia | 2 2 2 3 1 3 2 3 1 3 2 2 2 2 2 2 1 |
Bile Duct, Inflammation, Acute | 4 |
Centrilobular, Necrosis | 1 1 1 1 1 2 4 |
__________________________________________________________________________|
Mesentery | + + + + + +|
Hemorrhage | |
Artery, Mineralization | 3|
Fat, Inflammation | 2 |
Fat, Necrosis | 2 2 2 2 2|
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 4 2 2 1 2 2 1 2 1 |
Basophilic Focus | X X |
Hyperplasia | 2 |
Inflammation, Acute | 3 |
Metaplasia, Hepatocyte | 2 |
Artery, Mineralization | |
Duct, Hyperplasia | 3 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 2 |
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Squamous | 4 |
Mineralization | 2|
Necrosis | 1 3 3 1 1 3 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mineralization | 1 3 3 3|
Necrosis | 1 2 2 3 3 2 3 |
__________________________________________________________________________|
Tongue | + |
_____________________________________________________________________________________________________________________|
NTP Experiment-Test: 05180-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC GALLIUM ARSENIDE Date: 02/17/99
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:17:39
_____________________________________________________________________________________________________________________
| 6| 7| 7| 6| 7| 6| 7| 6| 7| 6| 7| 7| 6| 7| 7| 6| 6| 4| 5| 6| 6| 6| 6| 6| 6|
DAY ON TEST | 2| 3| 3| 0| 3| 7| 3| 0| 3| 9| 0| 3| 2| 3| 2| 7| 6| 4| 6| 1| 7| 5| 9| 4| 7|
| 7| 3| 3| 4| 3| 4| 3| 1| 3| 8| 4| 3| 7| 3| 0| 4| 0| 3| 6| 7| 8| 4| 8| 2| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
0.1 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
MG/M3 | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | + + +|
Aorta, Mineralization | 1 4|
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | 1 2 2 1 1 2 3 1 2 2 2 2 2 2 2 1 3 3|
Artery, Inflammation, Chronic | |
Artery, Mineralization | 2 2 4|
Atrium, Thrombosis | 2 2 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + A + + + + + +|
Degeneration, Cystic | |
Hyperplasia | 2 2 2 2 2 2 2 2 2 2 2 2 2|
Hypertrophy | 1 2 |
Necrosis | 2 2 |
Vacuolization Cytoplasmic | |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + A + + + + + +|
Hyperplasia | 4 4 3 2 2 3 3 4 3 2 3|
Bilateral, Hyperplasia | 3 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 |
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + M + + + M + + + + + + + +|
Hyperplasia | 1 3 2 2 3 2 2 2 3|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Hyperplasia | 2 3 1 3 2 2 1 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + A + + + + + +|
C-Cell, Hyperplasia | 1 1 2 1 1 1 1 2 3 1 1 2 1 4 2|
Follicular Cell, Hyperplasia | 3 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Peritoneum | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | |
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | |
Inflammation, Chronic Active | 4 3 2 4 3 |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 1 3 2 4 3 2 3 1 |
Inflammation, Chronic Active | 3 3 2|
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | |
_____________________________________________________________________________________________________________________|
NTP Experiment-Test: 05180-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC GALLIUM ARSENIDE Date: 02/17/99
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:17:39
_____________________________________________________________________________________________________________________
| 6| 7| 7| 6| 7| 6| 7| 6| 7| 6| 7| 7| 6| 7| 7| 6| 6| 4| 5| 6| 6| 6| 6| 6| 6|
DAY ON TEST | 2| 3| 3| 0| 3| 7| 3| 0| 3| 9| 0| 3| 2| 3| 2| 7| 6| 4| 6| 1| 7| 5| 9| 4| 7|
| 7| 3| 3| 4| 3| 4| 3| 1| 3| 8| 4| 3| 7| 3| 0| 4| 0| 3| 6| 7| 8| 4| 8| 2| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
0.1 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
MG/M3 | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
Mineralization | |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 4 4 |
Artery, Inflammation, Chronic Active | 3 3 3 |
Interstitial Cell, Hyperplasia | 3 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Thrombosis | |
__________________________________________________________________________|
Lymph Node | + + + + |
__________________________________________________________________________|
Lymph Node, Bronchial | + M + + + + + M M + + + M + + + + + + M + M M M +|
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + M + + M + + + + + + M + + + + + + + +|
Infiltration Cellular, Plasma Cell | 3 |
Inflammation, Chronic Active | 3 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node, Mediastinal | + + + + + + + + + + + + + + + + + + + M + + + + +|
Infiltration Cellular, | |
Polymorphonuclear | |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrosis | 2 2 2 2 2 2 3 2 1 |
Hematopoietic Cell Proliferation | 2 2 2 3|
Hyperplasia | |
Inflammation, Acute | |
Necrosis | 2 |
__________________________________________________________________________|
Thymus | + M + + + + + + + + + + + + + + + M + + + M + + M|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + M M + + + M + + + + + + +|
Galactocele | |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperkeratosis | |
Inflammation, Chronic Active | 4 4 3 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrous Osteodystrophy | 3 2 1 3 1 4|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Larynx | + + + + + + + + + + + + + + + + + + A + + + + + +|
Hyperplasia | 1 1|
Inflammation, Chronic Active | 1 1|
_____________________________________________________________________________________________________________________|
NTP Experiment-Test: 05180-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC GALLIUM ARSENIDE Date: 02/17/99
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:17:39
_____________________________________________________________________________________________________________________
| 6| 7| 7| 6| 7| 6| 7| 6| 7| 6| 7| 7| 6| 7| 7| 6| 6| 4| 5| 6| 6| 6| 6| 6| 6|
DAY ON TEST | 2| 3| 3| 0| 3| 7| 3| 0| 3| 9| 0| 3| 2| 3| 2| 7| 6| 4| 6| 1| 7| 5| 9| 4| 7|
| 7| 3| 3| 4| 3| 4| 3| 1| 3| 8| 4| 3| 7| 3| 0| 4| 0| 3| 6| 7| 8| 4| 8| 2| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
0.1 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
MG/M3 | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
Metaplasia, Squamous | 2|
Mineralization | 2 2|
Epiglottis, Hyperplasia | 1 2|
Epiglottis, Inflammation, Chronic | |
Active | 1 1|
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Atypical | 2 3 1 2|
Inflammation, Chronic Active | 3 3 3 3 3 3 3 3 3 3 3 3 4 3 2 3 3 3 3 3 3 3 3 3 4|
Metaplasia, Squamous | 2 |
Mineralization | 4|
Proteinosis | 1 3 2 2 2 3 3 3 2 3 2 2 2 2 2 2 3 4 3 2 3 2 3 2 2|
Alveolar Epithelium, Hyperplasia | 3 1 2 3 2 2 3 3 3 2 2 1 1 2 1 |
Alveolar Epithelium, Metaplasia | 2 2 2 2 3 3 2 2 3 3 3 2 2 1 2 2 2 1 2|
Artery, Mediastinum, Mineralization | 4|
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Suppurative | 2 3 1 2 3 |
Polyp Inflammatory | |
Thrombosis | 4 3 4 |
Olfactory Epithelium, Atrophy | 1 |
Olfactory Epithelium, Degeneration, | |
Hyaline | 1 2 2 1 1 2 1 1 1 1 2 2 1 2 1 1 1 1 1|
Olfactory Epithelium, Metaplasia, | |
Respiratory | 1 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + A + + + + + +|
Mineralization | 2 2|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | |
__________________________________________________________________________|
Eye | |
Degeneration | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | |
Infarct | |
Mineralization | 2 3 3|
Nephropathy | 3 4 4 2 3 2 4 3 4 4 4 4 3 3 4 4 3 2 2 3 3 4 4 4 4|
Renal Tubule, Hyperplasia | 4 3 1 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NTP Experiment-Test: 05180-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC GALLIUM ARSENIDE Date: 02/17/99
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:17:39
__________________________________________________________________________________________________________________________________
| 7| 7| 5| 5| 7| 7| 7| 6| 6| 7| 5| 5| 7| 6| 7| 7| 7| 6| 6| 7| 4| 6| 5| 3| 6| |
DAY ON TEST | 3| 0| 6| 9| 3| 3| 3| 1| 6| 3| 1| 6| 0| 6| 3| 3| 2| 8| 4| 3| 5| 2| 9| 9| 0| |
| 3| 2| 0| 0| 3| 3| 3| 5| 2| 3| 3| 2| 2| 0| 3| 3| 2| 0| 2| 3| 0| 1| 0| 4| 1| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| A |
0.1 | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
MG/M3 | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + A + + + + + + + + + + + + + + + +| 48 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + A + + + + + + + + + + + + + + + + + + + + + +| 47 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + A + + + + + + + + + + + + + + + +| 48 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Necrosis | 1 | 2 1.0|
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + A + + + + + + + + + + + + + + + +| 48 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + A + + + + + + + + + + + + + + + +| 48 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Basophilic Focus | X X X X X X X X X X X X| 21 |
Clear Cell Focus | X X | 6 |
Degeneration, Cystic | 4 4 2 3 | 10 2.2|
Eosinophilic Focus | X X X X | 5 |
Fatty Change | 1 2 | 8 1.8|
Hepatodiaphragmatic Nodule | X | 3 |
Mineralization | | 1 2.0|
Necrosis | 3 | 4 2.8|
Regeneration | 4 3 2 | 5 3.0|
Bile Duct, Hyperplasia | 4 2 2 2 1 4 3 2 2 2 3 3 2 2 2| 32 2.2|
Bile Duct, Inflammation, Acute | 4 | 2 4.0|
Centrilobular, Necrosis | 2 2 1 3 3 3 2 3 3| 16 2.1|
__________________________________________________________________________|____________|
Mesentery | + + + + + + + +| 14 |
Hemorrhage | 1 | 1 1.0|
Artery, Mineralization | 4 | 2 3.5|
Fat, Inflammation | | 1 2.0|
Fat, Necrosis | 2 2 2 2 3 3| 11 2.2|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Atrophy | 2 1 3 1 2 2 2 2 2 2 2 3 2 3 1 3 | 25 2.0|
Basophilic Focus | | 2 |
Hyperplasia | 3 | 2 2.5|
Inflammation, Acute | | 1 3.0|
Metaplasia, Hepatocyte | | 1 2.0|
Artery, Mineralization | 2 | 1 2.0|
Duct, Hyperplasia | | 1 3.0|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Atrophy | | 1 2.0|
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia, Squamous | | 1 4.0|
Mineralization | 3 | 2 2.5|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
NTP Experiment-Test: 05180-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC GALLIUM ARSENIDE Date: 02/17/99
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:17:39
__________________________________________________________________________________________________________________________________
| 7| 7| 5| 5| 7| 7| 7| 6| 6| 7| 5| 5| 7| 6| 7| 7| 7| 6| 6| 7| 4| 6| 5| 3| 6| |
DAY ON TEST | 3| 0| 6| 9| 3| 3| 3| 1| 6| 3| 1| 6| 0| 6| 3| 3| 2| 8| 4| 3| 5| 2| 9| 9| 0| |
| 3| 2| 0| 0| 3| 3| 3| 5| 2| 3| 3| 2| 2| 0| 3| 3| 2| 0| 2| 3| 0| 1| 0| 4| 1| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| A |
0.1 | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
MG/M3 | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
Necrosis | 3 4 4 | 9 2.6|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Mineralization | 2 1 4 4 | 8 2.6|
Necrosis | 3 3 2 2 1 3| 13 2.3|
__________________________________________________________________________|____________|
Tongue | + | 2 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood Vessel | + + + | 6 |
Aorta, Mineralization | 3 4 | 4 3.0|
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cardiomyopathy | 3 2 2 2 3 2 3 2 3 2 1 2 3 2 2 2 3 2 1 1 2 2 2| 41 2.0|
Artery, Inflammation, Chronic | 3 | 1 3.0|
Artery, Mineralization | 3 4 | 5 3.0|
Atrium, Thrombosis | 4 | 3 2.7|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Degeneration, Cystic | 1 | 1 1.0|
Hyperplasia | 2 2 2 2 2 2 2 2 2 2 | 23 2.0|
Hypertrophy | 2 | 3 1.7|
Necrosis | 2 2 | 4 2.0|
Vacuolization Cytoplasmic | 2 2 | 2 2.0|
__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Hyperplasia | 3 3 1 3 1 2 2 2 3 2 2 | 22 2.6|
Bilateral, Hyperplasia | | 1 3.0|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | 3 | 2 2.5|
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + M + + + + + + + + + + + + + + + + + + +| 47 |
Hyperplasia | 1 4 2 2 2 4 2 4 | 17 2.4|
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Pars Distalis, Hyperplasia | 1 2 2 2 1 4 2 2 | 15 2.0|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
C-Cell, Hyperplasia | 1 2 1 1 1 1 1 2 3 1 1 1 2 2 1 2 1 1| 33 1.5|
Follicular Cell, Hyperplasia | | 1 3.0|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Peritoneum | + | 1 |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
NTP Experiment-Test: 05180-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC GALLIUM ARSENIDE Date: 02/17/99
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:17:39
__________________________________________________________________________________________________________________________________
| 7| 7| 5| 5| 7| 7| 7| 6| 6| 7| 5| 5| 7| 6| 7| 7| 7| 6| 6| 7| 4| 6| 5| 3| 6| |
DAY ON TEST | 3| 0| 6| 9| 3| 3| 3| 1| 6| 3| 1| 6| 0| 6| 3| 3| 2| 8| 4| 3| 5| 2| 9| 9| 0| |
| 3| 2| 0| 0| 3| 3| 3| 5| 2| 3| 3| 2| 2| 0| 3| 3| 2| 0| 2| 3| 0| 1| 0| 4| 1| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| A |
0.1 | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
MG/M3 | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Atrophy | 4 | 1 4.0|
__________________________________________________________________________|____________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | 2 3 2 | 3 2.3|
Inflammation, Chronic Active | 4 3 2| 8 3.1|
__________________________________________________________________________|____________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | 1 3 | 11 2.3|
Inflammation, Chronic Active | 2 2 4| 6 2.7|
__________________________________________________________________________|____________|
Seminal Vesicle | + + A + + + + + A + + + + + + + + + + + + + + + +| 48 |
Inflammation, Chronic Active | 4| 1 4.0|
Mineralization | 2 | 1 2.0|
__________________________________________________________________________|____________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Atrophy | 3 3 4 | 5 3.6|
Artery, Inflammation, Chronic Active | 2 3 | 5 2.8|
Interstitial Cell, Hyperplasia | 2 | 2 2.5|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Thrombosis | 2 | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node | + + + + +| 9 |
__________________________________________________________________________|____________|
Lymph Node, Bronchial | + + + + + + M M + + + + M + + + + M + M + + + M M| 35 |
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + + M + + + + + + + + + + + + +| 46 |
Infiltration Cellular, Plasma Cell | | 1 3.0|
Inflammation, Chronic Active | | 1 3.0|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Lymph Node, Mediastinal | + M + + + + + + + + + M + + + + + + + + + + + M +| 46 |
Infiltration Cellular, | | |
Polymorphonuclear | 3 | 1 3.0|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Fibrosis | 2 2 1 2 2 2 2 2 | 17 1.9|
Hematopoietic Cell Proliferation | 2 3 | 6 2.3|
Hyperplasia | 4 | 1 4.0|
Inflammation, Acute | 3 | 1 3.0|
Necrosis | 2 3 2 2| 5 2.2|
__________________________________________________________________________|____________|
Thymus | + + + + + + + + + + + + + + + + + + + + + + M + +| 45 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + M + + M + + + + + + + + + M M M +| 42 |
Galactocele | 3 | 1 3.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
NTP Experiment-Test: 05180-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC GALLIUM ARSENIDE Date: 02/17/99
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:17:39
__________________________________________________________________________________________________________________________________
| 7| 7| 5| 5| 7| 7| 7| 6| 6| 7| 5| 5| 7| 6| 7| 7| 7| 6| 6| 7| 4| 6| 5| 3| 6| |
DAY ON TEST | 3| 0| 6| 9| 3| 3| 3| 1| 6| 3| 1| 6| 0| 6| 3| 3| 2| 8| 4| 3| 5| 2| 9| 9| 0| |
| 3| 2| 0| 0| 3| 3| 3| 5| 2| 3| 3| 2| 2| 0| 3| 3| 2| 0| 2| 3| 0| 1| 0| 4| 1| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| A |
0.1 | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
MG/M3 | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperkeratosis | 4 4 | 2 4.0|
Inflammation, Chronic Active | | 3 3.7|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Fibrous Osteodystrophy | 2 2 4 4 | 10 2.6|
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Hyperplasia | 1 1 | 4 1.0|
Inflammation, Chronic Active | 1 1 | 4 1.0|
Metaplasia, Squamous | 1 | 2 1.5|
Mineralization | 2 | 3 2.0|
Epiglottis, Hyperplasia | 1 1 | 4 1.3|
Epiglottis, Inflammation, Chronic | | |
Active | | 2 1.0|
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia, Atypical | 2 | 5 2.0|
Inflammation, Chronic Active | 3 3 3 3 3 3 3 2 3 3 3 3 3 2 4 3 3 3 3 3 2 3 2 2 2| 50 2.9|
Metaplasia, Squamous | | 1 2.0|
Mineralization | 4 4 | 3 4.0|
Proteinosis | 1 3 2 3 2 3 2 2 2 2 3 3 2 2 2 2 3 2 3 3 3 3 2 2 2| 50 2.4|
Alveolar Epithelium, Hyperplasia | 2 1 2 2 2 2| 21 2.0|
Alveolar Epithelium, Metaplasia | 2 2 3 3 3 3 3 2 2 2 2 3 2 3 2 | 34 2.3|
Artery, Mediastinum, Mineralization | 2 | 2 3.0|
__________________________________________________________________________|____________|
Nose | + + + + + + + + A + + + + + + + + + + + + + + + +| 49 |
Inflammation, Suppurative | 1 2 2 2 2 | 10 2.0|
Polyp Inflammatory | 3 | 1 3.0|
Thrombosis | 2 2 2 2 4| 8 2.9|
Olfactory Epithelium, Atrophy | | 1 1.0|
Olfactory Epithelium, Degeneration, | | |
Hyaline | 1 2 1 1 2 1 1 1 1 2 2 1 1 | 32 1.3|
Olfactory Epithelium, Metaplasia, | | |
Respiratory | | 1 1.0|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
NTP Experiment-Test: 05180-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC GALLIUM ARSENIDE Date: 02/17/99
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:17:39
__________________________________________________________________________________________________________________________________
| 7| 7| 5| 5| 7| 7| 7| 6| 6| 7| 5| 5| 7| 6| 7| 7| 7| 6| 6| 7| 4| 6| 5| 3| 6| |
DAY ON TEST | 3| 0| 6| 9| 3| 3| 3| 1| 6| 3| 1| 6| 0| 6| 3| 3| 2| 8| 4| 3| 5| 2| 9| 9| 0| |
| 3| 2| 0| 0| 3| 3| 3| 5| 2| 3| 3| 2| 2| 0| 3| 3| 2| 0| 2| 3| 0| 1| 0| 4| 1| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| A |
0.1 | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
MG/M3 | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont | | |
| | |
Mineralization | | 2 2.0|
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Ear | +| 1 |
__________________________________________________________________________|____________|
Eye | + | 1 |
Degeneration | 4 | 1 4.0|
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cyst | 3 | 1 3.0|
Infarct | 2| 1 2.0|
Mineralization | 2 4 | 5 2.8|
Nephropathy | 3 3 2 3 3 3 4 4 3 3 2 4 4 4 4 4 3 4 2 4 2 3 3 4 3| 50 3.3|
Renal Tubule, Hyperplasia | 2 | 4 2.5|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
NTP Experiment-Test: 05180-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC GALLIUM ARSENIDE Date: 02/17/99
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:17:39
_____________________________________________________________________________________________________________________
| 6| 6| 7| 7| 7| 5| 7| 6| 5| 6| 5| 6| 4| 7| 6| 6| 5| 6| 5| 7| 6| 5| 7| 7| 7|
DAY ON TEST | 6| 7| 3| 3| 3| 2| 3| 1| 1| 4| 2| 3| 2| 0| 0| 0| 4| 2| 3| 3| 6| 5| 3| 1| 3|
| 8| 8| 3| 3| 3| 0| 3| 8| 9| 5| 3| 3| 2| 2| 5| 4| 0| 1| 9| 3| 8| 7| 3| 3| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|
1.0 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
MG/M3 | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Anus, Hyperplasia | |
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Necrosis | 4 |
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Acute | 2 |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + A + + + + + + + + + + + + +|
Mineralization | 1 |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 3 3 |
Basophilic Focus | X X X X X X X X|
Clear Cell Focus | X X X X |
Degeneration, Cystic | 2 2 3 2 2 1 3 1 1|
Eosinophilic Focus | X |
Fatty Change | 3 1 1 1 |
Hepatodiaphragmatic Nodule | X|
Necrosis | |
Bile Duct, Hyperplasia | 2 3 2 1 2 2 2 2 2 2 2 3 |
Centrilobular, Necrosis | 2 2 1 2 |
__________________________________________________________________________|
Mesentery | + + + + + |
Artery, Mineralization | 3 |
Fat, Necrosis | 2 2 2 3 |
__________________________________________________________________________|
Oral Mucosa | |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 2 2 2 2 2 1 2 2 3 3 2 3 |
Basophilic Focus | X |
Hyperplasia | 2 |
Artery, Inflammation | 3 |
Artery, Mineralization | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Acute | 2 |
Mineralization | 2 1 |
Necrosis | 3 2 4 4 4|
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mineralization | 2 3 3 3 4 4 |
Necrosis | 3 3 2 1 1 2 3 3 2|
__________________________________________________________________________|
Tongue | |
__________________________________________________________________________|
Tooth | + |
Developmental Malformation | X |
Inflammation, Chronic Active | |
_____________________________________________________________________________________________________________________|
NTP Experiment-Test: 05180-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC GALLIUM ARSENIDE Date: 02/17/99
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:17:39
_____________________________________________________________________________________________________________________
| 6| 6| 7| 7| 7| 5| 7| 6| 5| 6| 5| 6| 4| 7| 6| 6| 5| 6| 5| 7| 6| 5| 7| 7| 7|
DAY ON TEST | 6| 7| 3| 3| 3| 2| 3| 1| 1| 4| 2| 3| 2| 0| 0| 0| 4| 2| 3| 3| 6| 5| 3| 1| 3|
| 8| 8| 3| 3| 3| 0| 3| 8| 9| 5| 3| 3| 2| 2| 5| 4| 0| 1| 9| 3| 8| 7| 3| 3| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|
1.0 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
MG/M3 | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | + + + + |
Aorta, Mineralization | 1 4 4 3 |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | 2 2 2 3 2 2 3 2 3 2 2 1 2 3 1 1 1 1 1 2 3 2|
Necrosis | |
Artery, Mineralization | 2 3 3 4 3 |
Atrium, Thrombosis | 2 2 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | |
Hyperplasia | 2 2 3 2 2 2 2 2 2 2 2 2|
Hypertrophy | |
Necrosis | 2 4 |
Vacuolization Cytoplasmic | |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 4 2 2 4 3 4 2 4 3 3 3 3 2 3 4 |
Bilateral, Hyperplasia | 3 3|
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 3 3 |
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + M + + M + + + + + + + + + + +|
Hyperplasia | 3 3 1 2 3 1 4 2 4 |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 2 |
Pars Distalis, Hyperplasia | 3 1 1 4 2 1 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
C-Cell, Hyperplasia | 1 1 1 1 1 2 1 1 1 2 1 1 1 2 3 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
Granuloma Sperm | 1 3 3 |
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 3 |
Inflammation, Chronic Active | 4 3 |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 1 4 1 3 |
Inflammation, Chronic Active | 2 |
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NTP Experiment-Test: 05180-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC GALLIUM ARSENIDE Date: 02/17/99
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:17:39
_____________________________________________________________________________________________________________________
| 6| 6| 7| 7| 7| 5| 7| 6| 5| 6| 5| 6| 4| 7| 6| 6| 5| 6| 5| 7| 6| 5| 7| 7| 7|
DAY ON TEST | 6| 7| 3| 3| 3| 2| 3| 1| 1| 4| 2| 3| 2| 0| 0| 0| 4| 2| 3| 3| 6| 5| 3| 1| 3|
| 8| 8| 3| 3| 3| 0| 3| 8| 9| 5| 3| 3| 2| 2| 5| 4| 0| 1| 9| 3| 8| 7| 3| 3| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|
1.0 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
MG/M3 | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
Atrophy | 3 |
Artery, Inflammation, Chronic Active | 2 2 |
Interstitial Cell, Hyperplasia | 2 2 3 2 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node | + + |
__________________________________________________________________________|
Lymph Node, Bronchial | + + + + + M + + M + + + + + + + + M + M + + + + +|
__________________________________________________________________________|
Lymph Node, Mandibular | + + M + + + + + + + + + + + M + + + + + + + M + +|
Infiltration Cellular, Plasma Cell | 4 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + M + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node, Mediastinal | + + + + + + + + + + + + + + + + + M + + + + + + +|
Infiltration Cellular, Plasma Cell | 4 |
Pigmentation | 2 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrosis | 2 2 2 2 2 |
Hematopoietic Cell Proliferation | 2 |
__________________________________________________________________________|
Thymus | + + + + + + + M + + + + + + + + + M + + + + + M +|
Cyst | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + M + M + + M + + + M + + + M + + + +|
Galactocele | 4 2 |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | 3 3 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrous Osteodystrophy | 3 3 1 3 3 3 2 |
Hyperostosis | |
Inflammation, Chronic Active | 3 |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | 3 |
Mineralization | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 2 1 1 1 1 1 |
Inflammation, Chronic Active | 1 2 1 1 1 1 2 1 |
Metaplasia, Squamous | 1 2 2 1 1 1 2 |
Mineralization | |
Epiglottis, Hyperplasia | 2 2 1 |
_____________________________________________________________________________________________________________________|
NTP Experiment-Test: 05180-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC GALLIUM ARSENIDE Date: 02/17/99
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:17:39
_____________________________________________________________________________________________________________________
| 6| 6| 7| 7| 7| 5| 7| 6| 5| 6| 5| 6| 4| 7| 6| 6| 5| 6| 5| 7| 6| 5| 7| 7| 7|
DAY ON TEST | 6| 7| 3| 3| 3| 2| 3| 1| 1| 4| 2| 3| 2| 0| 0| 0| 4| 2| 3| 3| 6| 5| 3| 1| 3|
| 8| 8| 3| 3| 3| 0| 3| 8| 9| 5| 3| 3| 2| 2| 5| 4| 0| 1| 9| 3| 8| 7| 3| 3| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|
1.0 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
MG/M3 | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
Epiglottis, Inflammation, Chronic | |
Active | 3 1 2 |
Epiglottis, Metaplasia, Squamous | 1 1 |
Epiglottis, Mineralization | |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst, Squamous | |
Hyperplasia, Atypical | 2 3 3 2 2 2 2 3 2 3|
Inflammation, Chronic Active | 4 4 4 4 4 4 4 4 4 4 4 4 3 4 3 3 4 4 4 4 3 3 4 3 4|
Metaplasia, Squamous | 2 4|
Mineralization | 2 2 4 4 4 3 |
Proteinosis | 3 4 4 3 4 4 3 4 3 4 4 3 2 2 3 4 4 3 4 4 3 4 2 4|
Thrombosis | 2 |
Alveolar Epithelium, Hyperplasia | 2 2 2 2 3 2 1 2 2 2|
Alveolar Epithelium, Metaplasia | 1 2 2 2 2 2 1 2 2 2 3 3 2 1 2 2 3 3 1 3 2 2|
Artery, Mediastinum, Mineralization | 2 3 4 4 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Suppurative | 1 3 2 2 1 2 |
Thrombosis | 4 4 3 |
Olfactory Epithelium, Atrophy | 2 1 |
Olfactory Epithelium, Degeneration, | |
Hyaline | 1 2 1 1 1 1 1 2 1 1 1|
Olfactory Epithelium, Metaplasia, | |
Respiratory | 1 1 |
Respiratory Epithelium, Degeneration,| |
Hyaline | |
Respiratory Epithelium, Metaplasia, | |
Squamous | |
Turbinate, Necrosis | 2 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mineralization | 3 1 |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | |
Cataract | |
Retina, Atrophy | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | 2 |
Infarct | |
Mineralization | 4 4 3 |
Nephropathy | 4 4 2 4 3 2 4 4 4 4 2 3 3 4 4 2 2 3 4 3 2 4 3 4 4|
Renal Tubule, Hyperplasia | 2 3 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NTP Experiment-Test: 05180-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC GALLIUM ARSENIDE Date: 02/17/99
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:17:39
__________________________________________________________________________________________________________________________________
| 6| 7| 5| 7| 7| 7| 7| 7| 5| 7| 4| 5| 7| 6| 6| 7| 6| 5| 6| 7| 6| 6| 7| 6| 3| |
DAY ON TEST | 1| 0| 9| 1| 3| 3| 0| 3| 3| 3| 2| 9| 0| 2| 0| 3| 0| 4| 3| 3| 1| 4| 3| 4| 1| |
| 5| 2| 4| 5| 3| 3| 2| 3| 3| 3| 2| 0| 0| 1| 2| 2| 1| 7| 1| 3| 4| 2| 3| 5| 0| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| A |
1.0 | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
MG/M3 | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + I + + + +| 49 |
Anus, Hyperplasia | 4 | 1 4.0|
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + A + + + + + + + + +| 49 |
Necrosis | | 1 4.0|
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Acute | | 1 2.0|
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Mineralization | | 1 1.0|
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Angiectasis | 1 2 3 | 5 2.4|
Basophilic Focus | X X X X X X X | 15 |
Clear Cell Focus | X X X X X | 9 |
Degeneration, Cystic | 2 | 10 1.9|
Eosinophilic Focus | X X X | 4 |
Fatty Change | 2 2 2 | 7 1.7|
Hepatodiaphragmatic Nodule | X | 2 |
Necrosis | 1 | 1 1.0|
Bile Duct, Hyperplasia | 2 4 3 1 1 2 2 2 2 3 1 2 1 3 1 2 2 3 | 30 2.1|
Centrilobular, Necrosis | 1 1 2 2 1 1 1 1 1 | 13 1.4|
__________________________________________________________________________|____________|
Mesentery | + + | 7 |
Artery, Mineralization | 4 | 2 3.5|
Fat, Necrosis | 2 | 5 2.2|
__________________________________________________________________________|____________|
Oral Mucosa | + | 1 |
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Atrophy | 1 2 3 1 2 2 2 2 1 3 1 2 2 1 1 | 27 1.9|
Basophilic Focus | X X | 3 |
Hyperplasia | | 1 2.0|
Artery, Inflammation | | 1 3.0|
Artery, Mineralization | 2 | 1 2.0|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Acute | | 1 2.0|
Mineralization | | 2 1.5|
Necrosis | 1 2 3 1 2 3 | 11 2.6|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Mineralization | 4 3 | 8 3.3|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
NTP Experiment-Test: 05180-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC GALLIUM ARSENIDE Date: 02/17/99
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:17:39
__________________________________________________________________________________________________________________________________
| 6| 7| 5| 7| 7| 7| 7| 7| 5| 7| 4| 5| 7| 6| 6| 7| 6| 5| 6| 7| 6| 6| 7| 6| 3| |
DAY ON TEST | 1| 0| 9| 1| 3| 3| 0| 3| 3| 3| 2| 9| 0| 2| 0| 3| 0| 4| 3| 3| 1| 4| 3| 4| 1| |
| 5| 2| 4| 5| 3| 3| 2| 3| 3| 3| 2| 0| 0| 1| 2| 2| 1| 7| 1| 3| 4| 2| 3| 5| 0| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| A |
1.0 | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
MG/M3 | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
Necrosis | 3 2 3 2 | 13 2.3|
__________________________________________________________________________|____________|
Tongue | + | 1 |
__________________________________________________________________________|____________|
Tooth | + +| 3 |
Developmental Malformation | X X| 3 |
Inflammation, Chronic Active | 3| 1 3.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood Vessel | + + | 6 |
Aorta, Mineralization | 4 1 | 6 2.8|
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cardiomyopathy | 3 1 4 2 2 2 2 2 2 3 3 2 2 2 3 2 2 1 | 40 2.1|
Necrosis | 3 | 1 3.0|
Artery, Mineralization | 4 1 | 7 2.9|
Atrium, Thrombosis | | 2 2.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Atrophy | 2 | 1 2.0|
Hyperplasia | 2 2 2 2 2 2 2 2 2 2 2 | 23 2.0|
Hypertrophy | 2 2 | 2 2.0|
Necrosis | 1 | 3 2.3|
Vacuolization Cytoplasmic | 2 | 1 2.0|
__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | 3 1 3 4 3 2 3 4 3 4 | 26 3.0|
Bilateral, Hyperplasia | 3 4 4 3 2 | 7 3.1|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | 3 2 | 4 2.8|
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
Hyperplasia | 4 3 3 4 1 2 2 | 16 2.6|
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Angiectasis | | 1 2.0|
Pars Distalis, Hyperplasia | 2 2 2 3 2 2 | 12 2.1|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
C-Cell, Hyperplasia | 1 1 1 1 1 1 3 2 2 1 1 1 2 1| 29 1.3|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
NTP Experiment-Test: 05180-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC GALLIUM ARSENIDE Date: 02/17/99
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:17:39
__________________________________________________________________________________________________________________________________
| 6| 7| 5| 7| 7| 7| 7| 7| 5| 7| 4| 5| 7| 6| 6| 7| 6| 5| 6| 7| 6| 6| 7| 6| 3| |
DAY ON TEST | 1| 0| 9| 1| 3| 3| 0| 3| 3| 3| 2| 9| 0| 2| 0| 3| 0| 4| 3| 3| 1| 4| 3| 4| 1| |
| 5| 2| 4| 5| 3| 3| 2| 3| 3| 3| 2| 0| 0| 1| 2| 2| 1| 7| 1| 3| 4| 2| 3| 5| 0| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| A |
1.0 | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
MG/M3 | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Granuloma Sperm | | 3 2.3|
__________________________________________________________________________|____________|
Preputial Gland | + + + + + + + + + + M + + + + + + + + + + + + + +| 49 |
Hyperplasia | 2 2 2 | 4 2.3|
Inflammation, Chronic Active | 3 | 3 3.3|
__________________________________________________________________________|____________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | 2 1 2 | 7 2.0|
Inflammation, Chronic Active | 2 | 2 2.0|
__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Atrophy | 3 3 3 4 | 5 3.2|
Artery, Inflammation, Chronic Active | 2 3 | 4 2.3|
Interstitial Cell, Hyperplasia | 1 1 | 6 1.8|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Lymph Node | + + + | 5 |
__________________________________________________________________________|____________|
Lymph Node, Bronchial | + + + M + + + + + + + + + + M + + + + + + M + + M| 42 |
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + M + M + + + + + + + M + + + + + + + + + + +| 44 |
Infiltration Cellular, Plasma Cell | 4 4| 3 4.0|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + M + + + + + + + + + + + + + + + + + + + + +| 48 |
__________________________________________________________________________|____________|
Lymph Node, Mediastinal | + + + + + + + + + + + + + + M + + + + + + + M + +| 47 |
Infiltration Cellular, Plasma Cell | | 1 4.0|
Pigmentation | | 1 2.0|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Fibrosis | 2 3 2 2 2 2 2 | 12 2.1|
Hematopoietic Cell Proliferation | | 1 2.0|
__________________________________________________________________________|____________|
Thymus | + + + + + + + + + + + M + + I + + M + + M M + + +| 42 |
Cyst | 3 | 1 3.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + M + + + + + + + + + + + + M + + M M + + + M +| 40 |
Galactocele | 3 | 3 3.0|
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Chronic Active | | 2 3.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Fibrous Osteodystrophy | 4 1 1 3 | 11 2.5|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
NTP Experiment-Test: 05180-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC GALLIUM ARSENIDE Date: 02/17/99
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:17:39
__________________________________________________________________________________________________________________________________
| 6| 7| 5| 7| 7| 7| 7| 7| 5| 7| 4| 5| 7| 6| 6| 7| 6| 5| 6| 7| 6| 6| 7| 6| 3| |
DAY ON TEST | 1| 0| 9| 1| 3| 3| 0| 3| 3| 3| 2| 9| 0| 2| 0| 3| 0| 4| 3| 3| 1| 4| 3| 4| 1| |
| 5| 2| 4| 5| 3| 3| 2| 3| 3| 3| 2| 0| 0| 1| 2| 2| 1| 7| 1| 3| 4| 2| 3| 5| 0| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| A |
1.0 | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
MG/M3 | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM - cont | | |
| | |
Hyperostosis | 2 | 1 2.0|
Inflammation, Chronic Active | | 1 3.0|
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hemorrhage | | 1 3.0|
Mineralization | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | 2 1 1 1 | 11 1.3|
Inflammation, Chronic Active | 2 1 1 1 | 12 1.3|
Metaplasia, Squamous | 2 1 1 | 10 1.4|
Mineralization | 2 | 1 2.0|
Epiglottis, Hyperplasia | 2 1 | 5 1.6|
Epiglottis, Inflammation, Chronic | | |
Active | 1 | 4 1.8|
Epiglottis, Metaplasia, Squamous | 1 | 3 1.0|
Epiglottis, Mineralization | 1 | 1 1.0|
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cyst, Squamous | 4 | 1 4.0|
Hyperplasia, Atypical | 1 2 4 4 4 2 1 3 | 18 2.5|
Inflammation, Chronic Active | 4 4 3 4 4 4 4 4 3 4 4 4 4 3 3 4 4 4 4 4 4 4 4 4 4| 50 3.8|
Metaplasia, Squamous | | 2 3.0|
Mineralization | 4 | 7 3.3|
Proteinosis | 3 4 4 3 4 3 4 3 4 4 4 4 4 2 4 2 4 4 3 4 3 3 3 2 2| 49 3.4|
Thrombosis | 4 | 2 3.0|
Alveolar Epithelium, Hyperplasia | 2 2 2 2 2 2 4 3 1 1 4 | 21 2.1|
Alveolar Epithelium, Metaplasia | 2 2 3 3 3 2 3 1 3 3 3 3 1 2 3 2 2 3 3 | 41 2.2|
Artery, Mediastinum, Mineralization | 3 | 5 3.2|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Suppurative | 2 2 | 8 1.9|
Thrombosis | 3 3 2 4 | 7 3.3|
Olfactory Epithelium, Atrophy | | 2 1.5|
Olfactory Epithelium, Degeneration, | | |
Hyaline | 1 2 2 1 2 2 2 2 1 1 1 1 1 1 | 25 1.3|
Olfactory Epithelium, Metaplasia, | | |
Respiratory | | 2 1.0|
Respiratory Epithelium, Degeneration,| | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
NTP Experiment-Test: 05180-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC GALLIUM ARSENIDE Date: 02/17/99
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:17:39
__________________________________________________________________________________________________________________________________
| 6| 7| 5| 7| 7| 7| 7| 7| 5| 7| 4| 5| 7| 6| 6| 7| 6| 5| 6| 7| 6| 6| 7| 6| 3| |
DAY ON TEST | 1| 0| 9| 1| 3| 3| 0| 3| 3| 3| 2| 9| 0| 2| 0| 3| 0| 4| 3| 3| 1| 4| 3| 4| 1| |
| 5| 2| 4| 5| 3| 3| 2| 3| 3| 3| 2| 0| 0| 1| 2| 2| 1| 7| 1| 3| 4| 2| 3| 5| 0| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| A |
1.0 | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
MG/M3 | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont | | |
| | |
Hyaline | 2 | 1 2.0|
Respiratory Epithelium, Metaplasia, | | |
Squamous | 2 | 1 2.0|
Turbinate, Necrosis | | 1 2.0|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Mineralization | 3 | 3 2.3|
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | + | 1 |
Cataract | 4 | 1 4.0|
Retina, Atrophy | 4 | 1 4.0|
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cyst | | 1 2.0|
Infarct | 3 2 | 2 2.5|
Mineralization | 4 | 4 3.8|
Nephropathy | 3 3 2 4 3 4 3 4 3 3 1 2 3 4 3 3 3 2 3 4 2 3 4 3 1| 50 3.1|
Renal Tubule, Hyperplasia | | 2 2.5|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
------------------------------------------------------------
---------- END OF REPORT ----------
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