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TDMS Study 05180-06 Pathology Tables

NTP Experiment-Test: 05180-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          GALLIUM ARSENIDE                                     Date: 02/17/99
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 08:17:39

                                                      2 YEAR CHRONIC RATS




       Facility:  Battelle Northwest

       Chemical CAS #:  1303-00-0000

       Lock Date:  03/13/97

       Cage Range:  All

       Reasons For Removal:    All

       Removal Date Range:     All

       Treatment Groups:       Include All




































                                                              Page   1



NTP Experiment-Test: 05180-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          GALLIUM ARSENIDE                                     Date: 02/17/99  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 08:17:39  
                                                                                                                                    

 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 6| 6| 3| 7| 7| 7| 7| 3| 5| 7| 5| 7| 5| 6| 7| 7| 6| 7| 5| 7| 6| 6|             
                             DAY ON TEST   | 3| 3| 3| 0| 4| 1| 3| 3| 3| 3| 0| 8| 3| 8| 1| 9| 8| 3| 3| 2| 3| 8| 3| 8| 2|             
                                           | 5| 5| 4| 7| 2| 0| 4| 0| 4| 5| 2| 8| 5| 2| 6| 0| 8| 0| 4| 1| 5| 9| 5| 4| 1|             

 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    CONTROL                                | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             

 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          | 2                                                                        |             
      Basophilic Focus                     | X  X  X     X     X  X  X  X     X     X     X     X  X  X  X  X  X  X  X|             
      Clear Cell Focus                     |    X                       X                          X                  |             
      Eosinophilic Focus                   |                                                       X           X      |             
      Fatty Change                         |          2  2        2           2                 4           1         |             
      Hepatodiaphragmatic Nodule           |                                        X                                 |             
      Inflammation, Granulomatous          |                            2                                            3|             
      Mixed Cell Focus                     |                                              X              X     X  X  X|             
      Necrosis                             |                                                                          |             
      Regeneration                         |                                           2                 2            |             
      Vacuolization Cytoplasmic, Focal     |                                              2     2                     |             
      Bile Duct, Hyperplasia               | 2     2  1                 1        2     2     2           2     1      |             
      Centrilobular, Necrosis              |          4                       1              1                        |             

                                            __________________________________________________________________________|             
   Mesentery                               |                                  +  +                                +   |             
      Fat, Necrosis                        |                                  2  2                                2   |             

                                            __________________________________________________________________________|             
   Oral Mucosa                             |                                                                          |             

                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              | 2                    1  1        2  1  1  2     1           1     2      |             
      Basophilic Focus                     |          X                                      X           X     X      |             
      Hyperplasia                          |                                                                          |             

                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Necrosis                             |          3  3                                      2                     |             

                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Mineralization                       |                                                                          |             
      Necrosis                             |          1                                                              1|             

                                            __________________________________________________________________________|             
   Tooth                                   |                                                                          |             
      Inflammation, Chronic Active         |                                                                          |             

 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cardiomyopathy                       | 2  1  2  1           2  2  2     2  1  1  2              1  2     2     1|             
      Atrium, Thrombosis                   |          4                                      4                        |             

 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

 _____________________________________________________________________________________________________________________|             
NTP Experiment-Test: 05180-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          GALLIUM ARSENIDE                                     Date: 02/17/99  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 08:17:39  
                                                                                                                                    

 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 6| 6| 3| 7| 7| 7| 7| 3| 5| 7| 5| 7| 5| 6| 7| 7| 6| 7| 5| 7| 6| 6|             
                             DAY ON TEST   | 3| 3| 3| 0| 4| 1| 3| 3| 3| 3| 0| 8| 3| 8| 1| 9| 8| 3| 3| 2| 3| 8| 3| 8| 2|             
                                           | 5| 5| 4| 7| 2| 0| 4| 0| 4| 5| 2| 8| 5| 2| 6| 0| 8| 0| 4| 1| 5| 9| 5| 4| 1|             

 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    CONTROL                                | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             

 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
      Degeneration, Cystic                 |                                                       3     2            |             
      Hyperplasia                          | 2  1  2                 2  2        2  2        2     2  2     2  2  2   |             
      Hypertrophy                          |                         2              2                    2     3  2   |             
      Vacuolization Cytoplasmic            |                                     2                             2      |             

                                            __________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |             2        1  1  2           1  2                 2  2         |             

                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +|             

                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |          2                                                               |             
      Pars Distalis, Hyperplasia           |                               2  3        3                              |             

                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      C-Cell, Hyperplasia                  |    3  1  1        2  2  2  2     1  2  2     2     2  1  1  2  1  2     1|             
      Follicular Cell, Hyperplasia         |                                                                         1|             

 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             

 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Clitoral Gland                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |             3                                                            |             
      Inflammation, Chronic Active         |                                                                          |             

                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |             3                                               3     2      |             

                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Granulomatous          |                               2                                          |             
      Myelofibrosis                        |          2                                                               |             

                                            __________________________________________________________________________|             
   Lymph Node                              | +                                                                 +      |             

                                            __________________________________________________________________________|             
   Lymph Node, Bronchial                   | +  +  M  +  M  M  +  +  M  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  M|             
      Infiltration Cellular, Plasma Cell   |                                                                          |             

                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  M  +  +  +  +  +  M  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +|             

                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

                                            __________________________________________________________________________|             
   Lymph Node, Mediastinal                 | M  M  +  +  +  M  +  M  +  +  M  +  +  +  +  +  +  +  +  +  +  +  M  M  +|             
      Infiltration Cellular,               |                                                                          |             
          Polymorphonuclear                |                                                                          |             

                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrosis                             |                                           1                              |             
      Hematopoietic Cell Proliferation     |             2                          4                       4         |             

                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  +  M  M  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             

 _____________________________________________________________________________________________________________________|             
NTP Experiment-Test: 05180-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          GALLIUM ARSENIDE                                     Date: 02/17/99  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 08:17:39  
                                                                                                                                    

 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 6| 6| 3| 7| 7| 7| 7| 3| 5| 7| 5| 7| 5| 6| 7| 7| 6| 7| 5| 7| 6| 6|             
                             DAY ON TEST   | 3| 3| 3| 0| 4| 1| 3| 3| 3| 3| 0| 8| 3| 8| 1| 9| 8| 3| 3| 2| 3| 8| 3| 8| 2|             
                                           | 5| 5| 4| 7| 2| 0| 4| 0| 4| 5| 2| 8| 5| 2| 6| 0| 8| 0| 4| 1| 5| 9| 5| 4| 1|             

 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    CONTROL                                | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             

 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Galactocele                          |                                           4                              |             

                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrous Osteodystrophy               |                                                                          |             
      Hyperostosis                         |                                                       2        3     2   |             

 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Larynx                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          | 1                          1                                             |             
      Inflammation, Chronic Active         |                         1                                      4         |             
      Metaplasia, Squamous                 | 1                       1                          1  1        2         |             
      Necrosis                             |                                                                4         |             
      Epiglottis, Hyperplasia              |                                                                          |             
      Epiglottis, Inflammation, Chronic    |                                                                          |             
          Active                           | 1                                                              2         |             
      Epiglottis, Metaplasia, Squamous     |                      1                                         4         |             

                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic Active         | 1        1           1                                2     1            |             
      Mineralization                       |                                                                          |             
      Proteinosis                          |                                                       1                  |             
      Alveolar Epithelium, Hyperplasia     |             3                                   1  1  1     1            |             

                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Suppurative            |                                           2                    3         |             
      Thrombosis                           |          2                                      3                        |             
      Olfactory Epithelium, Degeneration,  |                                                                          |             
           Hyaline                         |       1     1     1  1  1  1  2  3  1     2  1  1  2  3  1     1  1  1  1|             
      Respiratory Epithelium, Hyperplasia  |                                                                          |             

                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Eye                                     |                                                                   +      |             
      Cataract                             |                                                                   3      |             
      Retina, Atrophy                      |                                                                   4      |             

 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Amyloid Deposition                   |                                           3                              |             
      Inflammation, Suppurative            |                                                                          |             

 _____________________________________________________________________________________________________________________|             
NTP Experiment-Test: 05180-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          GALLIUM ARSENIDE                                     Date: 02/17/99  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 08:17:39  
                                                                                                                                    

 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 6| 6| 3| 7| 7| 7| 7| 3| 5| 7| 5| 7| 5| 6| 7| 7| 6| 7| 5| 7| 6| 6|             
                             DAY ON TEST   | 3| 3| 3| 0| 4| 1| 3| 3| 3| 3| 0| 8| 3| 8| 1| 9| 8| 3| 3| 2| 3| 8| 3| 8| 2|             
                                           | 5| 5| 4| 7| 2| 0| 4| 0| 4| 5| 2| 8| 5| 2| 6| 0| 8| 0| 4| 1| 5| 9| 5| 4| 1|             

 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    CONTROL                                | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             

 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
      Nephropathy                          | 2  2  2  2  4     2  2  2  2     1  2  2  3  2  2  3  2  1  2  1  2  3  3|             
      Renal Tubule, Hyperplasia            |             4                                                            |             
      Renal Tubule, Necrosis               |          3                                                               |             

                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

 _____________________________________________________________________________________________________________________|             
NTP Experiment-Test: 05180-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          GALLIUM ARSENIDE                                     Date: 02/17/99  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 08:17:39  
                                                                                                                                    

 __________________________________________________________________________________________________________________________________ 
                                           | 6| 7| 6| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 6| 5| 6| 5| 7| 6| 6| 6| 6| 7| 7| 4|            |
                             DAY ON TEST   | 7| 3| 6| 6| 3| 3| 3| 1| 8| 3| 0| 3| 3| 6| 0| 9| 8| 3| 0| 4| 7| 7| 3| 0| 9|            |
                                           | 7| 4| 0| 0| 4| 4| 5| 6| 5| 4| 2| 4| 4| 0| 6| 9| 1| 5| 4| 9| 9| 8| 5| 3| 7|      T (*) |

 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|      A     |
    CONTROL                                | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |

 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |

                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |

                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |

                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |

                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |

                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |

                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |

                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Angiectasis                          | 2                                                                        |      2  2.0|
      Basophilic Focus                     | X     X  X  X  X  X     X  X     X  X        X  X  X  X  X  X     X  X  X|     38     |
      Clear Cell Focus                     |                            X                 X                           |      5     |
      Eosinophilic Focus                   |                                                                          |      2     |
      Fatty Change                         | 3                       2                             1        4  1  1   |     12  2.1|
      Hepatodiaphragmatic Nodule           |                X                                               X         |      3     |
      Inflammation, Granulomatous          |                                                          1               |      3  2.0|
      Mixed Cell Focus                     |       X        X  X                    X              X                  |     10     |
      Necrosis                             |                                        2                                 |      1  2.0|
      Regeneration                         |                                                                          |      2  2.0|
      Vacuolization Cytoplasmic, Focal     |                                                 2                        |      3  2.0|
      Bile Duct, Hyperplasia               | 1                    2        2  1        2           2                  |     15  1.7|
      Centrilobular, Necrosis              |                      1        1           3                              |      6  1.8|

                                            __________________________________________________________________________|____________|
   Mesentery                               |                                        +     +              +            |   6        |
      Fat, Necrosis                        |                                        3     3              3            |      6  2.5|

                                            __________________________________________________________________________|____________|
   Oral Mucosa                             |                                              +                           |   1        |

                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Atrophy                              |                      1     4              1     2                    1   |     15  1.5|
      Basophilic Focus                     |                                                                          |      4     |
      Hyperplasia                          |                   2                          3     2                     |      3  2.3|

                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |

                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Necrosis                             | 3                                                                        |      4  2.8|

                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Mineralization                       |       2                          1                                       |      2  1.5|
      Necrosis                             |                                           2                              |      3  1.3|

                                            __________________________________________________________________________|____________|
   Tooth                                   |                                  +                                       |   1        |
      Inflammation, Chronic Active         |                                  2                                       |      1  2.0|

 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |

 __________________________________________________________________________________________________________________________________ 

  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
NTP Experiment-Test: 05180-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          GALLIUM ARSENIDE                                     Date: 02/17/99  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 08:17:39  
                                                                                                                                    

 __________________________________________________________________________________________________________________________________ 
                                           | 6| 7| 6| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 6| 5| 6| 5| 7| 6| 6| 6| 6| 7| 7| 4|            |
                             DAY ON TEST   | 7| 3| 6| 6| 3| 3| 3| 1| 8| 3| 0| 3| 3| 6| 0| 9| 8| 3| 0| 4| 7| 7| 3| 0| 9|            |
                                           | 7| 4| 0| 0| 4| 4| 5| 6| 5| 4| 2| 4| 4| 0| 6| 9| 1| 5| 4| 9| 9| 8| 5| 3| 7|      T (*) |

 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|      A     |
    CONTROL                                | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |

 __________________________________________________________________________________________________________________________________ 
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |            |
                                           |                                                                          |            |
      Cardiomyopathy                       |    2  1  1  1  1     2     2  1  2  2  1     2  1  2        1  1  2  2  1|     34  1.5|
      Atrium, Thrombosis                   |                                                                          |      2  4.0|

 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Degeneration, Cystic                 |                                                          1        2      |      4  2.0|
      Hyperplasia                          | 2  2     2  2  2     2     2        2  2  2  2     2           2     2   |     27  2.0|
      Hypertrophy                          |    2  2        2              2                    1                     |     10  2.0|
      Vacuolization Cytoplasmic            |                                                                          |      2  2.0|

                                            __________________________________________________________________________|____________|
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia                          |                1     3  3  2  3     2           1                 4      |     16  2.0|

                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |

                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  M  +|  47        |

                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cyst                                 |                                                                          |      1  2.0|
      Pars Distalis, Hyperplasia           |                                           2                             2|      5  2.4|

                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      C-Cell, Hyperplasia                  |    1  1  1  1  2  2  2  2  2  2  2  2  1  1  2  1  2  2  1  1  1  2     2|     41  1.6|
      Follicular Cell, Hyperplasia         |                                                                          |      1  1.0|

 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |

 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Clitoral Gland                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia                          |                      1                                                   |      2  2.0|
      Inflammation, Chronic Active         |                               4           2                              |      2  3.0|

                                            __________________________________________________________________________|____________|
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cyst                                 |       3              2                          3                    3   |      7  2.7|

                                            __________________________________________________________________________|____________|
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |

 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inflammation, Granulomatous          |                                                                          |      1  2.0|
      Myelofibrosis                        |                                                                          |      1  2.0|

                                            __________________________________________________________________________|____________|
   Lymph Node                              |                                           +                              |   3        |

                                            __________________________________________________________________________|____________|
   Lymph Node, Bronchial                   | M  +  M  +  +  +  I  M  +  +  +  +  +  +  +  M  +  +  +  M  M  M  +  +  +|  36        |
      Infiltration Cellular, Plasma Cell   |                                                                         4|      1  4.0|

                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +  M  +  +  M  +  +  +  M  +  +  +  +  +  +  +  +  +  +  M  +  +  +|  43        |

 __________________________________________________________________________________________________________________________________ 

  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
NTP Experiment-Test: 05180-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          GALLIUM ARSENIDE                                     Date: 02/17/99  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 08:17:39  
                                                                                                                                    

 __________________________________________________________________________________________________________________________________ 
                                           | 6| 7| 6| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 6| 5| 6| 5| 7| 6| 6| 6| 6| 7| 7| 4|            |
                             DAY ON TEST   | 7| 3| 6| 6| 3| 3| 3| 1| 8| 3| 0| 3| 3| 6| 0| 9| 8| 3| 0| 4| 7| 7| 3| 0| 9|            |
                                           | 7| 4| 0| 0| 4| 4| 5| 6| 5| 4| 2| 4| 4| 0| 6| 9| 1| 5| 4| 9| 9| 8| 5| 3| 7|      T (*) |

 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|      A     |
    CONTROL                                | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |

 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |

                                            __________________________________________________________________________|____________|
   Lymph Node, Mediastinal                 | M  +  +  M  +  +  +  +  +  M  M  +  M  +  +  +  +  +  +  M  +  M  M  M  +|  34        |
      Infiltration Cellular,               |                                                                          |            |
          Polymorphonuclear                |                                                                         3|      1  3.0|

                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Fibrosis                             | 2                                   1              2                     |      4  1.5|
      Hematopoietic Cell Proliferation     |                                              3                          4|      5  3.4|

                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +|  45        |

 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Galactocele                          |                                                                          |      1  4.0|

                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |

 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Fibrous Osteodystrophy               |                                                                      3   |      1  3.0|
      Hyperostosis                         | 1                    2                    1              4               |      7  2.1|

 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |

 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Larynx                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia                          |                                           1                              |      3  1.0|
      Inflammation, Chronic Active         |                                     1                          2         |      4  2.0|
      Metaplasia, Squamous                 |                1                    1              1           2        1|     10  1.2|
      Necrosis                             |                                                                          |      1  4.0|
      Epiglottis, Hyperplasia              |                                           1        1           2        1|      4  1.3|
      Epiglottis, Inflammation, Chronic    |                                                                          |            |
          Active                           |                                     1                          2         |      4  1.5|
      Epiglottis, Metaplasia, Squamous     |                1                    1                                    |      4  1.8|

                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inflammation, Chronic Active         | 1        1        1                 1     1                 1            |     11  1.1|
      Mineralization                       |                                                                      1   |      1  1.0|
      Proteinosis                          |                                                                          |      1  1.0|
      Alveolar Epithelium, Hyperplasia     | 3           1     1           1              2  1  2              2  1   |     14  1.5|

                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inflammation, Suppurative            |                                              4                           |      3  3.0|

 __________________________________________________________________________________________________________________________________ 

  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
NTP Experiment-Test: 05180-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          GALLIUM ARSENIDE                                     Date: 02/17/99  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 08:17:39  
                                                                                                                                    

 __________________________________________________________________________________________________________________________________ 
                                           | 6| 7| 6| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 6| 5| 6| 5| 7| 6| 6| 6| 6| 7| 7| 4|            |
                             DAY ON TEST   | 7| 3| 6| 6| 3| 3| 3| 1| 8| 3| 0| 3| 3| 6| 0| 9| 8| 3| 0| 4| 7| 7| 3| 0| 9|            |
                                           | 7| 4| 0| 0| 4| 4| 5| 6| 5| 4| 2| 4| 4| 0| 6| 9| 1| 5| 4| 9| 9| 8| 5| 3| 7|      T (*) |

 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|      A     |
    CONTROL                                | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |

 __________________________________________________________________________________________________________________________________ 
 RESPIRATORY SYSTEM - cont                 |                                                                          |            |
                                           |                                                                          |            |
      Thrombosis                           |                                                                          |      2  2.5|
      Olfactory Epithelium, Degeneration,  |                                                                          |            |
           Hyaline                         | 1  1  1     1  2  1  1  1  2  1  1  2  1  1     1     1  2  2        1  2|     39  1.3|
      Respiratory Epithelium, Hyperplasia  |                                                                      2   |      1  2.0|

                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |

 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Eye                                     |                                                                          |   1        |
      Cataract                             |                                                                          |      1  3.0|
      Retina, Atrophy                      |                                                                          |      1  4.0|

 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Amyloid Deposition                   |                                                                          |      1  3.0|
      Inflammation, Suppurative            |                                                                         2|      1  2.0|
      Nephropathy                          | 2  4  2  1  3  2  2  2  2  3  2  3  3  2  2  4  2  2  1  2  2  2  2  4  1|     48  2.2|
      Renal Tubule, Hyperplasia            |                         2                                                |      2  3.0|
      Renal Tubule, Necrosis               |                                                                          |      1  3.0|

                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |

 __________________________________________________________________________________________________________________________________ 

  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
NTP Experiment-Test: 05180-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          GALLIUM ARSENIDE                                     Date: 02/17/99  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 08:17:39  
                                                                                                                                    

 _____________________________________________________________________________________________________________________              
                                           | 7| 5| 5| 6| 7| 7| 7| 6| 6| 6| 7| 7| 7| 5| 7| 4| 7| 7| 4| 6| 5| 6| 6| 6| 7|             
                             DAY ON TEST   | 3| 6| 8| 1| 3| 3| 3| 9| 4| 8| 3| 3| 3| 9| 0| 9| 0| 3| 2| 2| 9| 3| 2| 6| 1|             
                                           | 4| 3| 5| 3| 5| 4| 4| 5| 9| 8| 5| 4| 5| 0| 2| 7| 2| 0| 2| 8| 0| 1| 1| 0| 3|             

 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    0.01                                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
    MG/M3                                  | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             

 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Acute                  |                                                                2         |             

                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Acute                  |                                                                3         |             

                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  A  +  +  +  +  +  +  +  +  I  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Necrosis                             |       2                                                                  |             

                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  A  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                                                      2   |             
      Basophilic Focus                     | X     X     X  X     X  X  X  X  X  X  X  X           X           X  X  X|             
      Clear Cell Focus                     | X           X                                                            |             
      Eosinophilic Focus                   |       X                          X                                       |             
      Fatty Change                         | 1        2                 2              2  2     3     2     1  3  1  3|             
      Hepatodiaphragmatic Nodule           |                                                       X                  |             
      Inflammation, Granulomatous          |                                                                          |             
      Mixed Cell Focus                     |                                           X                              |             
      Necrosis                             |                                                                          |             
      Regeneration                         |                                                             2            |             
      Bile Duct, Hyperplasia               |       1           1                          2  2  2     2  2            |             
      Centrilobular, Necrosis              |    2  1  2                 1                 2  2  1     3  2  1         |             

                                            __________________________________________________________________________|             
   Mesentery                               |                                     +        +     +                     |             
      Artery, Inflammation, Chronic Active |                                                                          |             
      Fat, Necrosis                        |                                     3        2     2                     |             

                                            __________________________________________________________________________|             
   Oral Mucosa                             |                      +                          +                        |             

                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                               1  2           2     1        2     1      |             
      Basophilic Focus                     |                                                       X                  |             
      Lipomatosis                          |                      3                                                   |             

                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +|             

                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Squamous                |                                                                          |             
      Necrosis                             |                                           3  3           2        3     1|             

                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Mineralization                       |                                  1                                       |             
      Necrosis                             |    2                                         3     2           2         |             

                                            __________________________________________________________________________|             
   Tongue                                  |                                                                          |             
      Hyperplasia, Squamous                |                                                                          |             

 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cardiomyopathy                       | 1  1        1  2  2  2  1  1  2  2  1     2        1     1     1  1  2  1|             

 _____________________________________________________________________________________________________________________|             
NTP Experiment-Test: 05180-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          GALLIUM ARSENIDE                                     Date: 02/17/99  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 08:17:39  
                                                                                                                                    

 _____________________________________________________________________________________________________________________              
                                           | 7| 5| 5| 6| 7| 7| 7| 6| 6| 6| 7| 7| 7| 5| 7| 4| 7| 7| 4| 6| 5| 6| 6| 6| 7|             
                             DAY ON TEST   | 3| 6| 8| 1| 3| 3| 3| 9| 4| 8| 3| 3| 3| 9| 0| 9| 0| 3| 2| 2| 9| 3| 2| 6| 1|             
                                           | 4| 3| 5| 3| 5| 4| 4| 5| 9| 8| 5| 4| 5| 0| 2| 7| 2| 0| 2| 8| 0| 1| 1| 0| 3|             

 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    0.01                                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
    MG/M3                                  | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             

 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |             
                                           |                                                                          |             
      Atrium, Thrombosis                   |                                                    2     2     4         |             

 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Degeneration, Cystic                 |                                                                          |             
      Hyperplasia                          | 2     2     2     2     2  2  2  4        2                 2  2     2  2|             
      Hypertrophy                          |       2        2           2                    2  2     2  2            |             
      Necrosis                             |                                     2           2  2           2         |             
      Vacuolization Cytoplasmic            |                                           2           2                  |             

                                            __________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  I  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |          2                 1  2                 2        2     2     1  4|             

                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  M  +  +  +  M  +  +  +  M  +  +  +  +  +  +  M  +  M  +  +  +  +  +|             
      Hyperplasia                          |                                                                         1|             

                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Pars Distalis, Hyperplasia           |                                                       2     3            |             

                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      C-Cell, Hyperplasia                  | 2     1  2  2  1     2  2  1     1  2  2     1  3        4  1  2  1  1  1|             

 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             

 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Clitoral Gland                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +|             
      Hyperplasia                          |          2                                2                          3   |             
      Inflammation, Chronic Active         |                                                                2         |             

                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                2                                         3               |             

                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Bone Marrow                             | +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Histiocytic             |                3                                                         |             

                                            __________________________________________________________________________|             
   Lymph Node                              |       +           +                             +                       +|             
      Renal, Hemorrhage                    |                                                                         2|             

                                            __________________________________________________________________________|             
   Lymph Node, Bronchial                   | +  +  +  +  +  +  +  +  M  +  M  +  +  +  +  M  +  +  +  +  +  M  +  +  M|             

                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  M  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +|             

                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

                                            __________________________________________________________________________|             
   Lymph Node, Mediastinal                 | M  +  +  +  +  M  +  +  M  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +|             

                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrosis                             |          2                                               2               |             
      Hematopoietic Cell Proliferation     |                                                       3                  |             
      Necrosis                             |                                                                3         |             

                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +|             

 _____________________________________________________________________________________________________________________|             
NTP Experiment-Test: 05180-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          GALLIUM ARSENIDE                                     Date: 02/17/99  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 08:17:39  
                                                                                                                                    

 _____________________________________________________________________________________________________________________              
                                           | 7| 5| 5| 6| 7| 7| 7| 6| 6| 6| 7| 7| 7| 5| 7| 4| 7| 7| 4| 6| 5| 6| 6| 6| 7|             
                             DAY ON TEST   | 3| 6| 8| 1| 3| 3| 3| 9| 4| 8| 3| 3| 3| 9| 0| 9| 0| 3| 2| 2| 9| 3| 2| 6| 1|             
                                           | 4| 3| 5| 3| 5| 4| 4| 5| 9| 8| 5| 4| 5| 0| 2| 7| 2| 0| 2| 8| 0| 1| 1| 0| 3|             

 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    0.01                                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
    MG/M3                                  | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             

 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             

 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Atypical                |                            2                                             |             

                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperostosis                         |                                                          2  3            |             

 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Larynx                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |          1                                                               |             
      Inflammation, Chronic Active         |                                                                          |             
      Metaplasia, Squamous                 |             1                    1                                   1  1|             
      Epiglottis, Hyperplasia              |                                                                          |             
      Epiglottis, Inflammation, Chronic    |                                                                          |             
          Active                           |                                                                          |             
      Epiglottis, Metaplasia, Squamous     |             1  1                                                     1   |             

                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic Active         | 1  1  2  2  1  2  1  1     1  2  1  2  1  2     2  2     1  2  1  1  1  2|             
      Proteinosis                          | 1  1  1  1     1  1           1        1  1        1                 1  1|             
      Thrombosis                           |    2                                                                     |             
      Alveolar Epithelium, Hyperplasia     | 1                                   2  1           2                    1|             
      Alveolar Epithelium, Metaplasia      |                                     1                                    |             
      Artery, Mediastinum, Inflammation    |                                                                          |             

                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Suppurative            |                                        2                             2   |             
      Thrombosis                           |          2                 3                       4     4     4         |             
      Olfactory Epithelium, Degeneration,  |                                                                          |             
           Hyaline                         | 2  2  1  2  1  2  1  1  2  2     2  1     2  1  1     1  2  2  1  1  1  1|             
      Olfactory Epithelium, Metaplasia,    |                                                                          |             
           Respiratory                     |                                                                      2   |             

                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Eye                                     |                   +                                   +                 +|             
      Cataract                             |                   3                                   4                 2|             
      Degeneration                         |                                                                          |             
      Retina, Atrophy                      |                   4                                   4                 2|             

                                            __________________________________________________________________________|             
   Zymbal's Gland                          |                                                                          |             

 _____________________________________________________________________________________________________________________|             
NTP Experiment-Test: 05180-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          GALLIUM ARSENIDE                                     Date: 02/17/99  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 08:17:39  
                                                                                                                                    

 _____________________________________________________________________________________________________________________              
                                           | 7| 5| 5| 6| 7| 7| 7| 6| 6| 6| 7| 7| 7| 5| 7| 4| 7| 7| 4| 6| 5| 6| 6| 6| 7|             
                             DAY ON TEST   | 3| 6| 8| 1| 3| 3| 3| 9| 4| 8| 3| 3| 3| 9| 0| 9| 0| 3| 2| 2| 9| 3| 2| 6| 1|             
                                           | 4| 3| 5| 3| 5| 4| 4| 5| 9| 8| 5| 4| 5| 0| 2| 7| 2| 0| 2| 8| 0| 1| 1| 0| 3|             

 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    0.01                                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
    MG/M3                                  | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             

 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM - cont              |                                                                          |             
                                           |                                                                          |             

 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                                             4            |             
      Infarct                              |          4                                   2     3                     |             
      Nephropathy                          | 2  2  2  2  2  2  2  3  3  2  2  3  2  2  4  1  2  3     2  1  3  2  4  4|             
      Renal Tubule, Hyperplasia            |                                                                          |             
      Renal Tubule, Necrosis               |                                                                3         |             
      Transitional Epithelium, Hyperplasia |          3                                                               |             

                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |       2                                                                  |             

 _____________________________________________________________________________________________________________________|             
NTP Experiment-Test: 05180-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          GALLIUM ARSENIDE                                     Date: 02/17/99  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 08:17:39  
                                                                                                                                    

 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 5| 5| 7| 5| 3| 6| 7| 7| 7| 5| 7| 6| 7| 6| 7| 6| 7| 7| 4| 7|            |
                             DAY ON TEST   | 2| 2| 3| 3| 2| 5| 0| 3| 4| 1| 0| 0| 3| 3| 2| 3| 8| 1| 8| 3| 8| 3| 3| 7| 3|            |
                                           | 6| 3| 5| 4| 6| 9| 9| 4| 8| 0| 6| 0| 4| 5| 3| 4| 5| 4| 7| 5| 8| 5| 5| 8| 5|      T (*) |

 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|      A     |
    0.01                                   | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      L     |
    MG/M3                                  | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |

 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |

                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Inflammation, Acute                  |                                                                          |      1  2.0|

                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |

                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Inflammation, Acute                  |                                                                          |      1  3.0|

                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Necrosis                             |                                                                          |      1  2.0|

                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |

                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |

                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Angiectasis                          |                                                    2                     |      2  2.0|
      Basophilic Focus                     | X  X     X  X  X     X  X     X  X  X  X     X  X  X  X  X  X  X  X     X|     36     |
      Clear Cell Focus                     |                X     X                 X     X                       X   |      7     |
      Eosinophilic Focus                   |       X                                                                  |      3     |
      Fatty Change                         |    2        2  2  3              1        2     3                       1|     19  2.0|
      Hepatodiaphragmatic Nodule           |                      X                 X                                 |      3     |
      Inflammation, Granulomatous          |                                                       1                  |      1  1.0|
      Mixed Cell Focus                     | X                       X              X        X  X  X        X  X      |      9     |
      Necrosis                             |                               2                                          |      1  2.0|
      Regeneration                         |                                                                          |      1  2.0|
      Bile Duct, Hyperplasia               |    2        2                          2  1  1                           |     12  1.7|
      Centrilobular, Necrosis              |    1              1                       1                              |     13  1.5|

                                            __________________________________________________________________________|____________|
   Mesentery                               | +  +  +  +           +  +     +           +              +     +     +   |  14        |
      Artery, Inflammation, Chronic Active |                                                                2         |      1  2.0|
      Fat, Necrosis                        | 3  2  2  2           3  2     2           2              2           2   |     13  2.2|

                                            __________________________________________________________________________|____________|
   Oral Mucosa                             |                                                                          |   2        |

                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Atrophy                              | 2  2  1     2     2                                2                    1|     13  1.6|
      Basophilic Focus                     |                                                          X              X|      3     |
      Lipomatosis                          |                                                                          |      1  3.0|

                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |

                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia, Squamous                |                                                                      3   |      1  3.0|
      Necrosis                             |                                  2        4                              |      7  2.6|

                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Mineralization                       |                                                                          |      1  1.0|
      Necrosis                             |                   1                             2                        |      6  2.0|

                                            __________________________________________________________________________|____________|
   Tongue                                  |                         +                                                |   1        |

 __________________________________________________________________________________________________________________________________ 

  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
NTP Experiment-Test: 05180-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          GALLIUM ARSENIDE                                     Date: 02/17/99  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 08:17:39  
                                                                                                                                    

 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 5| 5| 7| 5| 3| 6| 7| 7| 7| 5| 7| 6| 7| 6| 7| 6| 7| 7| 4| 7|            |
                             DAY ON TEST   | 2| 2| 3| 3| 2| 5| 0| 3| 4| 1| 0| 0| 3| 3| 2| 3| 8| 1| 8| 3| 8| 3| 3| 7| 3|            |
                                           | 6| 3| 5| 4| 6| 9| 9| 4| 8| 0| 6| 0| 4| 5| 3| 4| 5| 4| 7| 5| 8| 5| 5| 8| 5|      T (*) |

 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|      A     |
    0.01                                   | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      L     |
    MG/M3                                  | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |

 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
                                           |                                                                          |            |
      Hyperplasia, Squamous                |                         3                                                |      1  3.0|

 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cardiomyopathy                       |    1  1  2  1  1     1        1  2  2  2     2  1  1  1  1  1  2  1     2|     37  1.4|
      Atrium, Thrombosis                   |                                                                          |      3  2.7|

 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Degeneration, Cystic                 |                                     2              3                     |      2  2.5|
      Hyperplasia                          |       2        1     2        2     2           2        2  2  2        2|     23  2.0|
      Hypertrophy                          |                      1  2        1                 1                     |     11  1.7|
      Necrosis                             |                                                                          |      4  2.0|
      Vacuolization Cytoplasmic            |          2                             2                                 |      4  2.0|

                                            __________________________________________________________________________|____________|
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Hyperplasia                          |          2           1                          1                        |     11  1.8|

                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |

                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  M  +  M  +  +  +|  42        |
      Hyperplasia                          |                                  2                 1                     |      3  1.3|

                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Pars Distalis, Hyperplasia           |                   2                                                      |      3  2.3|

                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      C-Cell, Hyperplasia                  | 1  1     1  2  1  2  2  2     1  2  2     1  2  2  2  3  2  1  1  1  2  1|     41  1.6|

 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |

 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Clitoral Gland                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +|  48        |
      Hyperplasia                          |       3                                                                  |      4  2.5|
      Inflammation, Chronic Active         |                                                          2               |      2  2.0|

                                            __________________________________________________________________________|____________|
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cyst                                 |                                     3        2     3  4     2     1      |      8  2.5|

                                            __________________________________________________________________________|____________|
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |

 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Hyperplasia, Histiocytic             |                                                                          |      1  3.0|

                                            __________________________________________________________________________|____________|
   Lymph Node                              |             +                          +                                 |   6        |

 __________________________________________________________________________________________________________________________________ 

  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
NTP Experiment-Test: 05180-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          GALLIUM ARSENIDE                                     Date: 02/17/99  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 08:17:39  
                                                                                                                                    

 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 5| 5| 7| 5| 3| 6| 7| 7| 7| 5| 7| 6| 7| 6| 7| 6| 7| 7| 4| 7|            |
                             DAY ON TEST   | 2| 2| 3| 3| 2| 5| 0| 3| 4| 1| 0| 0| 3| 3| 2| 3| 8| 1| 8| 3| 8| 3| 3| 7| 3|            |
                                           | 6| 3| 5| 4| 6| 9| 9| 4| 8| 0| 6| 0| 4| 5| 3| 4| 5| 4| 7| 5| 8| 5| 5| 8| 5|      T (*) |

 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|      A     |
    0.01                                   | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      L     |
    MG/M3                                  | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |

 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
      Renal, Hemorrhage                    |                                                                          |      1  2.0|

                                            __________________________________________________________________________|____________|
   Lymph Node, Bronchial                   | +  +  M  M  +  +  +  M  M  +  M  +  +  +  +  M  +  M  M  +  M  +  +  +  +|  36        |

                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  M  M  +  +  +  +  +  +|  45        |

                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |

                                            __________________________________________________________________________|____________|
   Lymph Node, Mediastinal                 | M  +  +  M  +  +  +  +  +  I  M  +  +  M  +  +  +  M  +  +  +  +  M  +  +|  39        |

                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Fibrosis                             |       2     2                          2  2                              |      6  2.0|
      Hematopoietic Cell Proliferation     |          3                                                               |      2  3.0|
      Necrosis                             |                                                                          |      1  3.0|

                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |

 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia, Atypical                |                                                                          |      1  2.0|

                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |

 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperostosis                         |                                                    2                     |      3  2.3|

 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |

 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Larynx                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia                          |                                                                          |      1  1.0|
      Inflammation, Chronic Active         |       1                                      2        1     1  2         |      5  1.4|
      Metaplasia, Squamous                 |                                                                3         |      5  1.4|
      Epiglottis, Hyperplasia              |       1                                                     1            |      2  1.0|
      Epiglottis, Inflammation, Chronic    |                                                                          |            |
          Active                           |                                              3                           |      1  3.0|
      Epiglottis, Metaplasia, Squamous     |                                        3     3                 3         |      6  2.0|

                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inflammation, Chronic Active         | 1  2  1  2  2  2  1  2  1  1  2  2  2  2  1  2  1  1  2  2  1  2  2     2|     46  1.5|
      Proteinosis                          | 1              1     1           1  1        1        1  1  1  1  1     1|     24  1.0|
      Thrombosis                           |                                                                          |      1  2.0|
      Alveolar Epithelium, Hyperplasia     |       1        3     1                          2                        |      9  1.6|
      Alveolar Epithelium, Metaplasia      |                                                                          |      1  1.0|
      Artery, Mediastinum, Inflammation    |                                     3                                    |      1  3.0|

 __________________________________________________________________________________________________________________________________ 

  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
NTP Experiment-Test: 05180-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          GALLIUM ARSENIDE                                     Date: 02/17/99  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 08:17:39  
                                                                                                                                    

 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 5| 5| 7| 5| 3| 6| 7| 7| 7| 5| 7| 6| 7| 6| 7| 6| 7| 7| 4| 7|            |
                             DAY ON TEST   | 2| 2| 3| 3| 2| 5| 0| 3| 4| 1| 0| 0| 3| 3| 2| 3| 8| 1| 8| 3| 8| 3| 3| 7| 3|            |
                                           | 6| 3| 5| 4| 6| 9| 9| 4| 8| 0| 6| 0| 4| 5| 3| 4| 5| 4| 7| 5| 8| 5| 5| 8| 5|      T (*) |

 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|      A     |
    0.01                                   | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      L     |
    MG/M3                                  | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |

 __________________________________________________________________________________________________________________________________ 
 RESPIRATORY SYSTEM - cont                 |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inflammation, Suppurative            |                                     1              2                     |      4  1.8|
      Thrombosis                           |             2     2                                                      |      7  3.0|
      Olfactory Epithelium, Degeneration,  |                                                                          |            |
           Hyaline                         | 2  1  1        2  2  2  1                    1  1     1  2  1  2  2  2  2|     38  1.5|
      Olfactory Epithelium, Metaplasia,    |                                                                          |            |
           Respiratory                     |                                                    2                     |      2  2.0|

                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |

 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Eye                                     | +                                                                       +|   5        |
      Cataract                             | 4                                                                        |      4  3.3|
      Degeneration                         |                                                                         4|      1  4.0|
      Retina, Atrophy                      | 3                                                                        |      4  3.3|

                                            __________________________________________________________________________|____________|
   Zymbal's Gland                          |                                                                      +   |   1        |

 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cyst                                 |                                                                          |      1  4.0|
      Infarct                              |                                                                          |      3  3.0|
      Nephropathy                          | 3  2  3  2  2  2  1  3  2     3  4  3  3  2  2  3  3  3  2  2  2  2     3|     47  2.4|
      Renal Tubule, Hyperplasia            |                                  3                                       |      1  3.0|
      Renal Tubule, Necrosis               |                                                                          |      1  3.0|
      Transitional Epithelium, Hyperplasia |                                                                          |      1  3.0|

                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hemorrhage                           |                                                                          |      1  2.0|

 __________________________________________________________________________________________________________________________________ 

  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
NTP Experiment-Test: 05180-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          GALLIUM ARSENIDE                                     Date: 02/17/99  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 08:17:39  
                                                                                                                                    

 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 4| 5| 6| 6| 6| 7| 3| 7| 6| 1| 7| 6| 3| 4| 7| 7| 7| 7| 6| 6| 5| 6| 7|             
                             DAY ON TEST   | 4| 3| 6| 3| 0| 4| 0| 3| 3| 3| 6| 9| 3| 7| 5| 4| 3| 3| 3| 3| 4| 8| 4| 7| 3|             
                                           | 6| 4| 2| 4| 9| 6| 5| 5| 9| 5| 8| 8| 4| 8| 4| 8| 5| 5| 4| 4| 7| 4| 7| 4| 5|             

 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
    0.1                                    | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
    MG/M3                                  | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             

 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  I  +  +  +  +  +  +|             

                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +|             

                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +|             

                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  A  +  +  +  A  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +|             

                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  A  +  A  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +|             

                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                                    1                    2|             
      Basophilic Focus                     | X  X     X  X  X     X  X  X  X     X        X  X  X  X  X  X            |             
      Clear Cell Focus                     | X        X                                                           X  X|             
      Eosinophilic Focus                   |    X           X                                                         |             
      Fatty Change                         |       3           2     1                    3                    2      |             
      Hepatodiaphragmatic Nodule           |                                                                          |             
      Mixed Cell Focus                     |                               X                    X  X                  |             
      Necrosis                             |                               2              3           2               |             
      Vacuolization Cytoplasmic, Focal     |                                                                   3      |             
      Bile Duct, Hyperplasia               |                2  2                    2                                 |             
      Centrilobular, Necrosis              |             2  2                          2                 2  1     1   |             

                                            __________________________________________________________________________|             
   Mesentery                               |       +        +     +                                                   |             
      Fat, Necrosis                        |       3        2     2                                                   |             

                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              | 1  2  1        2     1  1              2  1        1  1     1  2     1   |             
      Basophilic Focus                     |                                     X                                    |             
      Hyperplasia                          |                                                                          |             

                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Squamous                |                                                                          |             
      Necrosis                             |       3                                                              3   |             

                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Mineralization                       |                                                                          |             
      Necrosis                             |                2                                                         |             

                                            __________________________________________________________________________|             
   Tongue                                  |                                                       +                  |             
      Hyperplasia, Squamous                |                                                                          |             

                                            __________________________________________________________________________|             
   Tooth                                   |                                                                         +|             
      Developmental Malformation           |                                                                         X|             

 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cardiomyopathy                       | 1  2              1  2              2  1        1  2  2  2  1           2|             

 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Degeneration, Cystic                 |                                                                          |             

 _____________________________________________________________________________________________________________________|             
NTP Experiment-Test: 05180-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          GALLIUM ARSENIDE                                     Date: 02/17/99  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 08:17:39  
                                                                                                                                    

 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 4| 5| 6| 6| 6| 7| 3| 7| 6| 1| 7| 6| 3| 4| 7| 7| 7| 7| 6| 6| 5| 6| 7|             
                             DAY ON TEST   | 4| 3| 6| 3| 0| 4| 0| 3| 3| 3| 6| 9| 3| 7| 5| 4| 3| 3| 3| 3| 4| 8| 4| 7| 3|             
                                           | 6| 4| 2| 4| 9| 6| 5| 5| 9| 5| 8| 8| 4| 8| 4| 8| 5| 5| 4| 4| 7| 4| 7| 4| 5|             

 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
    0.1                                    | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
    MG/M3                                  | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             

 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
      Hyperplasia                          | 2                    2     2  2     2           2  2  2  2  2        1  2|             
      Hypertrophy                          |    4     2                                         2     2               |             
      Necrosis                             |                                              2                           |             
      Thrombosis                           |                                           2                              |             
      Vacuolization Cytoplasmic            | 2                    2                          2                        |             

                                            __________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |             1                          3     1  2  1     2  1  1         |             
      Bilateral, Hyperplasia               |                                                                          |             

                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +|             
      Hyperplasia                          |                                                          1               |             

                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |             3                                                  2         |             
      Pars Distalis, Hyperplasia           |          4           3                                               3   |             

                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +|             
      C-Cell, Hyperplasia                  | 3  2  2  3           2  1     2     1  1     1  1  1  2  2     2  1  1  1|             

 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             

 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Clitoral Gland                          | +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +|             
      Hyperplasia                          |                               3     1                                    |             
      Inflammation, Chronic Active         |                                                                          |             

                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |             3                       3                 2     3            |             

                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |                                                                          |             

 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Necrosis                             |                                              4                           |             

                                            __________________________________________________________________________|             
   Lymph Node                              |                                        +     +                           |             
      Renal, Hemorrhage                    |                                                                          |             

                                            __________________________________________________________________________|             
   Lymph Node, Bronchial                   | +  +  M  +  +  +  +  +  +  +  M  M  M  +  M  +  +  +  +  +  +  +  +  +  +|             

                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +|             

                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

                                            __________________________________________________________________________|             
   Lymph Node, Mediastinal                 | +  +  M  M  +  +  +  M  M  +  +  +  +  +  M  +  +  +  +  +  +  +  M  +  +|             

                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrosis                             |                2  2                                                      |             
      Hematopoietic Cell Proliferation     |       2     4                                3              4            |             
      Hemorrhage                           |                                                                          |             
      Necrosis                             |                                                                          |             

                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  M  +  +  +|             

 _____________________________________________________________________________________________________________________|             
NTP Experiment-Test: 05180-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          GALLIUM ARSENIDE                                     Date: 02/17/99  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 08:17:39  
                                                                                                                                    

 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 4| 5| 6| 6| 6| 7| 3| 7| 6| 1| 7| 6| 3| 4| 7| 7| 7| 7| 6| 6| 5| 6| 7|             
                             DAY ON TEST   | 4| 3| 6| 3| 0| 4| 0| 3| 3| 3| 6| 9| 3| 7| 5| 4| 3| 3| 3| 3| 4| 8| 4| 7| 3|             
                                           | 6| 4| 2| 4| 9| 6| 5| 5| 9| 5| 8| 8| 4| 8| 4| 8| 5| 5| 4| 4| 7| 4| 7| 4| 5|             

 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
    0.1                                    | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
    MG/M3                                  | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             

 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             

 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Galactocele                          |                2                    2                                    |             
      Hyperplasia, Atypical                |                                                                          |             

                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrous Osteodystrophy               |                                                                          |             
      Hyperostosis                         |             3                                2                           |             

 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Larynx                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic Active         | 1                    2                                                   |             
      Metaplasia, Squamous                 | 1                    1                                      1     1      |             
      Epiglottis, Inflammation, Chronic    |                                                                          |             
          Active                           |                                                                          |             
      Epiglottis, Metaplasia, Squamous     |                                                                          |             

                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst, Squamous                       |                                        4                                 |             
      Hyperplasia, Atypical                |    1                                               2     4           3   |             
      Inflammation, Chronic Active         | 3  2  3  3  2  2  3  3  2  3  3  2  3  3     2  3  4  3  3  2  3  3  2  3|             
      Metaplasia, Squamous                 |                            2           3                                 |             
      Proteinosis                          | 2  2  3  2  2  1  3  1  2  2  2  4  2  2     2  2  3  2  1  2  1  3  2  2|             
      Alveolar Epithelium, Hyperplasia     |                      3        1     2           3     3           1     2|             
      Alveolar Epithelium, Metaplasia      | 2  3     3     1  2  3     3  2     2  1        3  3  3  3     2  2  2  3|             

                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |                                                                          |             
      Inflammation, Suppurative            | 2                          2                                         3   |             
      Thrombosis                           |                4                                               4         |             
      Olfactory Epithelium, Degeneration,  |                                                                          |             
           Hyaline                         | 1  1  2  2  1  1     1  1  2  1        1     1  3  3  2  1  2  3  2  1   |             
      Olfactory Epithelium, Metaplasia,    |                                                                          |             
           Respiratory                     | 2                    1                                                   |             
      Respiratory Epithelium, Metaplasia,  |                                                                          |             
           Squamous                        |                            2                                             |             

                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Eye                                     |                                                                      +  +|             

 _____________________________________________________________________________________________________________________|             
NTP Experiment-Test: 05180-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          GALLIUM ARSENIDE                                     Date: 02/17/99  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 08:17:39  
                                                                                                                                    

 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 4| 5| 6| 6| 6| 7| 3| 7| 6| 1| 7| 6| 3| 4| 7| 7| 7| 7| 6| 6| 5| 6| 7|             
                             DAY ON TEST   | 4| 3| 6| 3| 0| 4| 0| 3| 3| 3| 6| 9| 3| 7| 5| 4| 3| 3| 3| 3| 4| 8| 4| 7| 3|             
                                           | 6| 4| 2| 4| 9| 6| 5| 5| 9| 5| 8| 8| 4| 8| 4| 8| 5| 5| 4| 4| 7| 4| 7| 4| 5|             

 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
    0.1                                    | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
    MG/M3                                  | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             

 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM - cont              |                                                                          |             
                                           |                                                                          |             
      Cataract                             |                                                                      4   |             
      Degeneration                         |                                                                         4|             
      Retina, Atrophy                      |                                                                      4   |             
      Sclera, Inflammation, Acute          |                                                                          |             

 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                                                          |             
      Hydronephrosis                       |                                              3                           |             
      Infarct                              |                                        2                                 |             
      Nephropathy                          | 2  2  2  1  2  2  3  2  1  3  2     3  2        3  3  3  4  2  2  2  2  3|             
      Renal Tubule, Hyperplasia            |                                                       4                  |             

                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

 _____________________________________________________________________________________________________________________|             
NTP Experiment-Test: 05180-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          GALLIUM ARSENIDE                                     Date: 02/17/99  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 08:17:39  
                                                                                                                                    

 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 6| 5| 7| 7| 7| 6| 6| 6| 7| 7| 7| 7| 7| 6| 7| 7| 6| 7| 7| 3| 6| 6| 6|            |
                             DAY ON TEST   | 3| 3| 3| 3| 3| 3| 3| 0| 7| 6| 0| 3| 3| 2| 3| 7| 3| 3| 0| 3| 3| 1| 3| 7| 3|            |
                                           | 4| 5| 1| 4| 4| 4| 5| 4| 9| 0| 1| 5| 4| 3| 4| 4| 5| 5| 3| 5| 4| 0| 9| 4| 0|      T (*) |

 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|      A     |
    0.1                                    | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      L     |
    MG/M3                                  | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |

 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |

                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |

                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |

                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |

                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |

                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  46        |

                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  46        |

                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Angiectasis                          |                         1                       1                       2|      5  1.4|
      Basophilic Focus                     | X  X  X  X  X  X  X  X  X  X  X  X  X     X  X  X  X     X  X     X  X  X|     38     |
      Clear Cell Focus                     |             X                       X                    X        X      |      8     |
      Eosinophilic Focus                   | X                                                                        |      3     |
      Fatty Change                         |          2           4  2     1        2              2                  |     11  2.2|
      Hepatodiaphragmatic Nodule           |                                                    X        X     X      |      3     |
      Mixed Cell Focus                     |          X     X                                                  X      |      6     |
      Necrosis                             |                                                                1         |      4  2.0|
      Vacuolization Cytoplasmic, Focal     |                                                    2                     |      2  2.5|
      Bile Duct, Hyperplasia               |    1                    1                             2              2   |      7  1.7|
      Centrilobular, Necrosis              |                                                       2              2   |      8  1.8|

                                            __________________________________________________________________________|____________|
   Mesentery                               |                   +                 +              +                     |   6        |
      Fat, Necrosis                        |                   2                 2              2                     |      6  2.2|

                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Atrophy                              | 2  2     2                    2        1              2  1  2            |     21  1.5|
      Basophilic Focus                     |                                                                          |      1     |
      Hyperplasia                          |    3                                                                     |      1  3.0|

                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |

                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia, Squamous                |                                                    2                     |      1  2.0|
      Necrosis                             |                      2                                                   |      3  2.7|

                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Mineralization                       |                                                    2                    1|      2  1.5|
      Necrosis                             |                                                       1                  |      2  1.5|

                                            __________________________________________________________________________|____________|
   Tongue                                  |          +                                                               |   2        |
      Hyperplasia, Squamous                |          3                                                               |      1  3.0|

                                            __________________________________________________________________________|____________|
   Tooth                                   |                                                                          |   1        |
      Developmental Malformation           |                                                                          |      1     |

 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |

 __________________________________________________________________________________________________________________________________ 

  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
NTP Experiment-Test: 05180-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          GALLIUM ARSENIDE                                     Date: 02/17/99  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 08:17:39  
                                                                                                                                    

 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 6| 5| 7| 7| 7| 6| 6| 6| 7| 7| 7| 7| 7| 6| 7| 7| 6| 7| 7| 3| 6| 6| 6|            |
                             DAY ON TEST   | 3| 3| 3| 3| 3| 3| 3| 0| 7| 6| 0| 3| 3| 2| 3| 7| 3| 3| 0| 3| 3| 1| 3| 7| 3|            |
                                           | 4| 5| 1| 4| 4| 4| 5| 4| 9| 0| 1| 5| 4| 3| 4| 4| 5| 5| 3| 5| 4| 0| 9| 4| 0|      T (*) |

 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|      A     |
    0.1                                    | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      L     |
    MG/M3                                  | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |

 __________________________________________________________________________________________________________________________________ 
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |            |
                                           |                                                                          |            |
      Cardiomyopathy                       | 2  1        1  1  1  1     1  2  1        2  1  2     1  1  1  1     1   |     29  1.4|

 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Degeneration, Cystic                 |                   2                                                      |      1  2.0|
      Hyperplasia                          | 2     2           2  2     2     2  1     2  2  2  2     2  2            |     25  1.9|
      Hypertrophy                          |    2                             2  2           3     2                  |      9  2.3|
      Necrosis                             |                                        2                                 |      2  2.0|
      Thrombosis                           |                                                                          |      1  2.0|
      Vacuolization Cytoplasmic            |                2                                                         |      4  2.0|

                                            __________________________________________________________________________|____________|
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia                          |    2           2        2  3  2  2     2                                 |     15  1.8|
      Bilateral, Hyperplasia               |                                                    2                     |      1  2.0|

                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |

                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  I  +  +  +  +  +  +  +  +|  47        |
      Hyperplasia                          |                            3                                2            |      3  2.0|

                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Angiectasis                          |                                                                          |      2  2.5|
      Pars Distalis, Hyperplasia           | 4                       3              4                             2   |      7  3.3|

                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      C-Cell, Hyperplasia                  | 1  1  2  1     2  2  1  2  2     1  2     2  1  1  1  1  1  2     4  2   |     38  1.6|

 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |

 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Clitoral Gland                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +|  47        |
      Hyperplasia                          |                                                             4            |      3  2.7|
      Inflammation, Chronic Active         |                                                             3            |      1  3.0|

                                            __________________________________________________________________________|____________|
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cyst                                 |                                  2  3  2  2        3        1            |     10  2.4|

                                            __________________________________________________________________________|____________|
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Hemorrhage                           |             3                                                            |      1  3.0|

 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Necrosis                             |                                                                          |      1  4.0|

                                            __________________________________________________________________________|____________|
   Lymph Node                              |    +                                                                     |   3        |
      Renal, Hemorrhage                    |    2                                                                     |      1  2.0|

 __________________________________________________________________________________________________________________________________ 

  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
NTP Experiment-Test: 05180-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          GALLIUM ARSENIDE                                     Date: 02/17/99  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 08:17:39  
                                                                                                                                    

 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 6| 5| 7| 7| 7| 6| 6| 6| 7| 7| 7| 7| 7| 6| 7| 7| 6| 7| 7| 3| 6| 6| 6|            |
                             DAY ON TEST   | 3| 3| 3| 3| 3| 3| 3| 0| 7| 6| 0| 3| 3| 2| 3| 7| 3| 3| 0| 3| 3| 1| 3| 7| 3|            |
                                           | 4| 5| 1| 4| 4| 4| 5| 4| 9| 0| 1| 5| 4| 3| 4| 4| 5| 5| 3| 5| 4| 0| 9| 4| 0|      T (*) |

 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|      A     |
    0.1                                    | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      L     |
    MG/M3                                  | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |

 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Lymph Node, Bronchial                   | M  +  +  +  +  +  +  +  +  +  M  +  +  M  M  +  +  +  M  +  +  M  +  +  +|  39        |

                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | M  +  M  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +|  45        |

                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |

                                            __________________________________________________________________________|____________|
   Lymph Node, Mediastinal                 | +  +  M  +  +  +  +  M  +  +  +  +  M  M  +  M  +  +  +  +  +  +  +  +  +|  39        |

                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Fibrosis                             |                   2     2                       2                        |      5  2.0|
      Hematopoietic Cell Proliferation     |                                        2           3                     |      6  3.0|
      Hemorrhage                           |                               3                                          |      1  3.0|
      Necrosis                             |                                                       2                  |      1  2.0|

                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +  +  +  +  +  M  +  +  +  +  +  +  +  M  M  M  +  +  +  M  +  +  +  M|  41        |

 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Galactocele                          |                                                                          |      2  2.0|
      Hyperplasia, Atypical                |                                                    3                     |      1  3.0|

                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |

 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Fibrous Osteodystrophy               |                                                    1                     |      1  1.0|
      Hyperostosis                         |                2              4              3        3                 3|      7  2.9|

 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |

 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Larynx                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inflammation, Chronic Active         |                2                                                         |      3  1.7|
      Metaplasia, Squamous                 |                1                                      2                 1|      7  1.1|
      Epiglottis, Inflammation, Chronic    |                                                                          |            |
          Active                           |                1                                                         |      1  1.0|
      Epiglottis, Metaplasia, Squamous     |                                                          2               |      1  2.0|

                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cyst, Squamous                       |                                                                          |      1  4.0|
      Hyperplasia, Atypical                | 1  2                                2        3  2                        |      9  2.2|
      Inflammation, Chronic Active         | 3  3  3  3  3  2  3  3  2  3  3  3  3  2  3  3  3  3  3  3  3  3  2  3  3|     49  2.8|
      Metaplasia, Squamous                 |                                                                          |      2  2.5|
      Proteinosis                          | 2  2  3  1  2     1  3     2  3  3  2  2  2  3  3  2  2  2  2  3  2  2  3|     47  2.2|
      Alveolar Epithelium, Hyperplasia     | 1  2     1     2  4  1     2  3                    2              3      |     17  2.1|

 __________________________________________________________________________________________________________________________________ 

  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
NTP Experiment-Test: 05180-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          GALLIUM ARSENIDE                                     Date: 02/17/99  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 08:17:39  
                                                                                                                                    

 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 6| 5| 7| 7| 7| 6| 6| 6| 7| 7| 7| 7| 7| 6| 7| 7| 6| 7| 7| 3| 6| 6| 6|            |
                             DAY ON TEST   | 3| 3| 3| 3| 3| 3| 3| 0| 7| 6| 0| 3| 3| 2| 3| 7| 3| 3| 0| 3| 3| 1| 3| 7| 3|            |
                                           | 4| 5| 1| 4| 4| 4| 5| 4| 9| 0| 1| 5| 4| 3| 4| 4| 5| 5| 3| 5| 4| 0| 9| 4| 0|      T (*) |

 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|      A     |
    0.1                                    | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      L     |
    MG/M3                                  | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |

 __________________________________________________________________________________________________________________________________ 
 RESPIRATORY SYSTEM - cont                 |                                                                          |            |
                                           |                                                                          |            |
      Alveolar Epithelium, Metaplasia      | 3  3  2  2  3     3  2     2  3  3  3  2  3     2        2  2  1        3|     36  2.4|

                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Hemorrhage                           |                                                       3                  |      1  3.0|
      Inflammation, Suppurative            |          1  2  2        1        3     2                                 |      9  2.0|
      Thrombosis                           |                                                       1              1   |      4  2.5|
      Olfactory Epithelium, Degeneration,  |                                                                          |            |
           Hyaline                         |       1           1  1  2  1  2  1  2     1  2        1     1  2         |     33  1.5|
      Olfactory Epithelium, Metaplasia,    |                                                                          |            |
           Respiratory                     |                                                                          |      2  1.5|
      Respiratory Epithelium, Metaplasia,  |                                                                          |            |
           Squamous                        |                                                                          |      1  2.0|

                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |

 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Eye                                     |                            +        +        +              +            |   6        |
      Cataract                             |                                                                          |      1  4.0|
      Degeneration                         |                            3        3                       4            |      4  3.5|
      Retina, Atrophy                      |                                                                          |      1  4.0|
      Sclera, Inflammation, Acute          |                                              2                           |      1  2.0|

 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cyst                                 |    3                                                                    3|      2  3.0|
      Hydronephrosis                       |                                                                          |      1  3.0|
      Infarct                              |                                                                          |      1  2.0|
      Nephropathy                          | 2  3  2  2  3  3  3  3  2  3  2  2  2  2  2  2  3  4  2  3  4  1  3  2  3|     47  2.4|
      Renal Tubule, Hyperplasia            |                                                                          |      1  4.0|

                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |

 __________________________________________________________________________________________________________________________________ 

  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
NTP Experiment-Test: 05180-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          GALLIUM ARSENIDE                                     Date: 02/17/99  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 08:17:39  
                                                                                                                                    

 _____________________________________________________________________________________________________________________              
                                           | 6| 5| 5| 7| 5| 7| 7| 6| 6| 6| 6| 6| 6| 6| 7| 7| 5| 7| 7| 7| 5| 4| 7| 7| 6|             
                             DAY ON TEST   | 8| 9| 6| 3| 3| 3| 0| 7| 9| 3| 7| 3| 3| 3| 3| 0| 5| 3| 3| 0| 5| 2| 1| 3| 0|             
                                           | 5| 0| 4| 4| 4| 0| 9| 7| 1| 1| 4| 2| 1| 2| 5| 2| 4| 5| 4| 4| 6| 2| 2| 5| 5|             

 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
    1.0                                    | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
    MG/M3                                  | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             

 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Esophagus                               | +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Necrosis                             |                2                                2                        |             

                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                                          2               |             
      Basophilic Focus                     | X  X     X  X  X  X  X  X  X  X     X     X        X  X  X     X  X  X  X|             
      Clear Cell Focus                     |             X                                      X                     |             
      Degeneration, Cystic                 |                   1                                                      |             
      Eosinophilic Focus                   |                                                                          |             
      Fatty Change                         | 1  2        1        1        2  2     2                                 |             
      Hepatodiaphragmatic Nodule           | X                                                     X                  |             
      Inflammation, Granulomatous          |                                                                      3   |             
      Mixed Cell Focus                     |                                                          X               |             
      Necrosis                             |                                                 2  2                     |             
      Thrombosis                           |    2                                                                     |             
      Bile Duct, Hyperplasia               | 1  3           2  1           2        2     3                           |             
      Centrilobular, Necrosis              | 2  1  2  1     1        1     1  1                          1            |             

                                            __________________________________________________________________________|             
   Mesentery                               |          +     +           +  +     +                    +               |             
      Fat, Necrosis                        |          2     2           2  2     2                    2               |             

                                            __________________________________________________________________________|             
   Pancreas                                | +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              | 1  1              1     2                 1     1     1     1     1     2|             
      Basophilic Focus                     |                                                             X            |             

                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Diverticulum                         |                                           X                              |             
      Hyperplasia, Squamous                |                                  3                                       |             
      Mineralization                       |                                                                   2      |             
      Necrosis                             |                4        1  3                                             |             

                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Mineralization                       |             1                                                     3      |             
      Necrosis                             | 1                                               2                        |             

 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Blood Vessel                            |                                                                   +      |             
      Aorta, Mineralization                |                                                                   4      |             

                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cardiomyopathy                       | 1        1  1  2     1  1           2     1        1  1  1  1     3  1   |             
      Artery, Mineralization               |                                                                   4      |             

 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             

 _____________________________________________________________________________________________________________________|             
NTP Experiment-Test: 05180-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          GALLIUM ARSENIDE                                     Date: 02/17/99  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 08:17:39  
                                                                                                                                    

 _____________________________________________________________________________________________________________________              
                                           | 6| 5| 5| 7| 5| 7| 7| 6| 6| 6| 6| 6| 6| 6| 7| 7| 5| 7| 7| 7| 5| 4| 7| 7| 6|             
                             DAY ON TEST   | 8| 9| 6| 3| 3| 3| 0| 7| 9| 3| 7| 3| 3| 3| 3| 0| 5| 3| 3| 0| 5| 2| 1| 3| 0|             
                                           | 5| 0| 4| 4| 4| 0| 9| 7| 1| 1| 4| 2| 1| 2| 5| 2| 4| 5| 4| 4| 6| 2| 2| 5| 5|             

 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
    1.0                                    | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
    MG/M3                                  | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             

 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Adrenal Cortex                          | +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                   1  2     2  2           2        2        2     2  2  2|             
      Hypertrophy                          | 2        2              2  2                 2     3                 1   |             
      Necrosis                             | 2                                               3                        |             
      Vacuolization Cytoplasmic            |                         2           2                                    |             

                                            __________________________________________________________________________|             
   Adrenal Medulla                         | +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |          1                 3  3  2  2     1                              |             

                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                                                          |             

                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                           2                       4      |             

                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                               2                                          |             
      Pars Distalis, Angiectasis           |                3                                                         |             
      Pars Distalis, Hyperplasia           |                   1                          3        2     2  1         |             

                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      C-Cell, Hyperplasia                  | 2  1           2  2  1  1  2  1     2  1     1  2  2  2  2  1  1     2   |             

 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             

 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Clitoral Gland                          | +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                                                          |             
      Inflammation, Chronic Active         |                   2        2                                             |             
      Metaplasia, Squamous                 |                                                                          |             

                                            __________________________________________________________________________|             
   Ovary                                   | +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                            3                    3           2            |             

                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

                                            __________________________________________________________________________|             
   Lymph Node                              |                                              +  +                        |             
      Renal, Hemorrhage                    |                                                                          |             

                                            __________________________________________________________________________|             
   Lymph Node, Bronchial                   | +  +  A  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +|             

                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

                                            __________________________________________________________________________|             
   Lymph Node, Mediastinal                 | +  +  +  +  +  +  +  +  M  +  +  +  +  +  M  +  +  +  M  +  +  M  +  +  +|             

                                            __________________________________________________________________________|             
   Spleen                                  | +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrosis                             |                2                                                         |             
      Hematopoietic Cell Proliferation     |                                                                          |             
      Hemorrhage                           |                               2     3                                    |             

                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  M  M  +  +  +  +  M  +  M  +  +  +  +  +  +  +  +  +  M|             

 _____________________________________________________________________________________________________________________|             
NTP Experiment-Test: 05180-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          GALLIUM ARSENIDE                                     Date: 02/17/99  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 08:17:39  
                                                                                                                                    

 _____________________________________________________________________________________________________________________              
                                           | 6| 5| 5| 7| 5| 7| 7| 6| 6| 6| 6| 6| 6| 6| 7| 7| 5| 7| 7| 7| 5| 4| 7| 7| 6|             
                             DAY ON TEST   | 8| 9| 6| 3| 3| 3| 0| 7| 9| 3| 7| 3| 3| 3| 3| 0| 5| 3| 3| 0| 5| 2| 1| 3| 0|             
                                           | 5| 0| 4| 4| 4| 0| 9| 7| 1| 1| 4| 2| 1| 2| 5| 2| 4| 5| 4| 4| 6| 2| 2| 5| 5|             

 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
    1.0                                    | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
    MG/M3                                  | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             

 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             

 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrous Osteodystrophy               |                                                                   4      |             
      Hyperostosis                         |                3                             3                    2      |             

 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Larynx                                  | +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                            1                                             |             
      Inflammation, Chronic Active         |                                     3  1           1                     |             
      Metaplasia, Squamous                 |                            1  1     4  1           1              2      |             
      Epiglottis, Hyperplasia              |                            1                                      2      |             
      Epiglottis, Metaplasia, Squamous     |                            1        3                                    |             

                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Atypical                |          3     2           4                          2  1               |             
      Inflammation, Chronic Active         | 3  4  2  4  3  4  4  4  4  4  4  3  3  4  4  4  4  4  3  4  3  3  3  4  3|             
      Metaplasia, Squamous                 |                      2                                                   |             
      Mineralization                       |                                                                   4      |             
      Proteinosis                          | 3  4  2  4  4  4  4  3  4  3  3  4  3  4  3  4  4  4  4  4  4  4  2  4  3|             
      Alveolar Epithelium, Hyperplasia     |                4     2        2           4                       2  2   |             
      Alveolar Epithelium, Metaplasia      | 2  2     3  2  2  2  2  2  3  3  3  2  2  2  3  3  3  2  2  3     3  3  2|             
      Artery, Mediastinum, Mineralization  |                                                                   4      |             

                                            __________________________________________________________________________|             
   Nose                                    | +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Suppurative            |                                                                      2   |             
      Thrombosis                           |    2                                         3              4            |             
      Olfactory Epithelium, Atrophy        |                                                 1                 2      |             
      Olfactory Epithelium, Degeneration,  |                                                                          |             
           Hyaline                         | 2  3        1  2  2  2        1  1  1  2  1     1  1  1  1  1  2         |             
      Olfactory Epithelium, Metaplasia,    |                                                                          |             
           Respiratory                     |                                                                      3   |             

                                            __________________________________________________________________________|             
   Trachea                                 | +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Mineralization                       |                                                                   3      |             

 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Ear                                     |                                                                          |             

                                            __________________________________________________________________________|             
   Eye                                     |                               +                                          |             
      Cataract                             |                               3                                          |             

 _____________________________________________________________________________________________________________________|             
NTP Experiment-Test: 05180-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          GALLIUM ARSENIDE                                     Date: 02/17/99  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 08:17:39  
                                                                                                                                    

 _____________________________________________________________________________________________________________________              
                                           | 6| 5| 5| 7| 5| 7| 7| 6| 6| 6| 6| 6| 6| 6| 7| 7| 5| 7| 7| 7| 5| 4| 7| 7| 6|             
                             DAY ON TEST   | 8| 9| 6| 3| 3| 3| 0| 7| 9| 3| 7| 3| 3| 3| 3| 0| 5| 3| 3| 0| 5| 2| 1| 3| 0|             
                                           | 5| 0| 4| 4| 4| 0| 9| 7| 1| 1| 4| 2| 1| 2| 5| 2| 4| 5| 4| 4| 6| 2| 2| 5| 5|             

 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
    1.0                                    | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
    MG/M3                                  | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             

 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM - cont              |                                                                          |             
                                           |                                                                          |             
      Retina, Atrophy                      |                               3                                          |             

 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Kidney                                  | +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                                                          |             
      Infarct                              |                                              2                           |             
      Mineralization                       |                                                                   3      |             
      Nephropathy                          | 2  2     3     2  2  3  2  4  2  2  3  2  4  1     3  2  4  2  1  4  2  2|             
      Thrombosis                           |                                                                          |             
      Renal Tubule, Hyperplasia            |                                           1                              |             

                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

 _____________________________________________________________________________________________________________________|             
NTP Experiment-Test: 05180-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          GALLIUM ARSENIDE                                     Date: 02/17/99  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 08:17:39  
                                                                                                                                    

 __________________________________________________________________________________________________________________________________ 
                                           | 3| 2| 7| 6| 7| 4| 6| 2| 6| 6| 7| 5| 4| 5| 5| 4| 7| 7| 6| 7| 7| 7| 6| 5| 7|            |
                             DAY ON TEST   | 1| 5| 1| 7| 3| 1| 9| 1| 7| 8| 3| 6| 7| 1| 0| 7| 3| 3| 9| 0| 3| 3| 8| 9| 1|            |
                                           | 0| 4| 2| 4| 4| 8| 1| 5| 7| 4| 4| 4| 8| 9| 6| 6| 4| 5| 6| 3| 4| 5| 8| 4| 6|      T (*) |

 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|      A     |
    1.0                                    | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      L     |
    MG/M3                                  | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |

 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |

                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |

                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |

                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |

                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Necrosis                             |                                                                          |      2  2.0|

                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |

                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |

                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Angiectasis                          |                         2                                      2         |      3  2.0|
      Basophilic Focus                     |       X     X           X  X  X  X     X  X     X  X  X  X     X  X     X|     34     |
      Clear Cell Focus                     |                                                                          |      2     |
      Degeneration, Cystic                 |                                                                          |      1  1.0|
      Eosinophilic Focus                   |                                                    X                     |      1     |
      Fatty Change                         |             2  2  2                    2  2                              |     12  1.8|
      Hepatodiaphragmatic Nodule           |                         X  X                                             |      4     |
      Inflammation, Granulomatous          |                                                                          |      1  3.0|
      Mixed Cell Focus                     |                                                             X            |      2     |
      Necrosis                             |                                                                          |      2  2.0|
      Thrombosis                           |                                                                          |      1  2.0|
      Bile Duct, Hyperplasia               |                         2  1  1        2                 2           3   |     13  1.9|
      Centrilobular, Necrosis              |          1     1           1  1     1  1                 2           1   |     17  1.2|

                                            __________________________________________________________________________|____________|
   Mesentery                               |       +                    +        +                    +        +      |  11        |
      Fat, Necrosis                        |       2                    2        2                    2        2      |     11  2.0|

                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Atrophy                              |          2     1                             2  1                        |     14  1.3|
      Basophilic Focus                     |                                                                          |      1     |

                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |

                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Diverticulum                         |                                                                          |      1     |
      Hyperplasia, Squamous                |                                        2                                 |      2  2.5|
      Mineralization                       |                                                                          |      1  2.0|
      Necrosis                             |             4                                                            |      4  3.0|

                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Mineralization                       |                               1                                          |      3  1.7|
      Necrosis                             |                2                                         3               |      4  2.0|

 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Blood Vessel                            |                                                                          |   1        |

 __________________________________________________________________________________________________________________________________ 

  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
NTP Experiment-Test: 05180-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          GALLIUM ARSENIDE                                     Date: 02/17/99  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 08:17:39  
                                                                                                                                    

 __________________________________________________________________________________________________________________________________ 
                                           | 3| 2| 7| 6| 7| 4| 6| 2| 6| 6| 7| 5| 4| 5| 5| 4| 7| 7| 6| 7| 7| 7| 6| 5| 7|            |
                             DAY ON TEST   | 1| 5| 1| 7| 3| 1| 9| 1| 7| 8| 3| 6| 7| 1| 0| 7| 3| 3| 9| 0| 3| 3| 8| 9| 1|            |
                                           | 0| 4| 2| 4| 4| 8| 1| 5| 7| 4| 4| 4| 8| 9| 6| 6| 4| 5| 6| 3| 4| 5| 8| 4| 6|      T (*) |

 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|      A     |
    1.0                                    | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      L     |
    MG/M3                                  | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |

 __________________________________________________________________________________________________________________________________ 
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |            |
                                           |                                                                          |            |
      Aorta, Mineralization                |                                                                          |      1  4.0|

                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cardiomyopathy                       |       1     1  1  2     2  1  2  1              1  3  1  1  1  1  2  2  2|     31  1.4|
      Artery, Mineralization               |                                                                          |      1  4.0|

 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Hyperplasia                          |       2  2  2     2        2                    2  2  2  2     2  2     2|     22  2.0|
      Hypertrophy                          |          1  2              2                       2                     |     11  1.9|
      Necrosis                             |                                                                          |      2  2.5|
      Vacuolization Cytoplasmic            |             2                                                            |      3  2.0|

                                            __________________________________________________________________________|____________|
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Hyperplasia                          |       2  2     2  4           4                                      4   |     12  2.5|

                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Hyperplasia                          |                                                                2         |      1  2.0|

                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +|  46        |
      Hyperplasia                          |                         3                                                |      3  3.0|

                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Angiectasis                          |                                                                          |      1  2.0|
      Pars Distalis, Angiectasis           |                                                          4               |      2  3.5|
      Pars Distalis, Hyperplasia           |          4           3        4              2                           |      9  2.4|

                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      C-Cell, Hyperplasia                  |          1  2  1  1     1  1     2  1  2  2     2  1           2     1  1|     33  1.5|

 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |

 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Clitoral Gland                          | +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Hyperplasia                          |          2        4                                                      |      2  3.0|
      Inflammation, Chronic Active         |                                                                          |      2  2.0|
      Metaplasia, Squamous                 |                                                          2               |      1  2.0|

                                            __________________________________________________________________________|____________|
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Cyst                                 |                         3                             3                  |      5  2.8|

                                            __________________________________________________________________________|____________|
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |

 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |

                                            __________________________________________________________________________|____________|
   Lymph Node                              |                                     +                                +  +|   5        |

 __________________________________________________________________________________________________________________________________ 

  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
NTP Experiment-Test: 05180-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          GALLIUM ARSENIDE                                     Date: 02/17/99  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 08:17:39  
                                                                                                                                    

 __________________________________________________________________________________________________________________________________ 
                                           | 3| 2| 7| 6| 7| 4| 6| 2| 6| 6| 7| 5| 4| 5| 5| 4| 7| 7| 6| 7| 7| 7| 6| 5| 7|            |
                             DAY ON TEST   | 1| 5| 1| 7| 3| 1| 9| 1| 7| 8| 3| 6| 7| 1| 0| 7| 3| 3| 9| 0| 3| 3| 8| 9| 1|            |
                                           | 0| 4| 2| 4| 4| 8| 1| 5| 7| 4| 4| 4| 8| 9| 6| 6| 4| 5| 6| 3| 4| 5| 8| 4| 6|      T (*) |

 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|      A     |
    1.0                                    | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      L     |
    MG/M3                                  | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |

 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
      Renal, Hemorrhage                    |                                                                         2|      1  2.0|

                                            __________________________________________________________________________|____________|
   Lymph Node, Bronchial                   | M  M  +  +  +  +  M  +  +  +  M  +  +  +  +  +  M  M  +  M  M  +  +  +  +|  40        |

                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  M  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +|  47        |

                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |

                                            __________________________________________________________________________|____________|
   Lymph Node, Mediastinal                 | +  M  +  +  +  +  +  M  +  +  +  +  +  +  +  +  M  M  M  +  M  M  +  +  +|  39        |

                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Fibrosis                             |                                                                          |      1  2.0|
      Hematopoietic Cell Proliferation     |                            3                                             |      1  3.0|
      Hemorrhage                           |                                                                          |      2  2.5|

                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  45        |

 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |

                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |

 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Fibrous Osteodystrophy               |                         3                                                |      2  3.5|
      Hyperostosis                         |          4              3  2        1                    3  2            |      9  2.6|

 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |

 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Larynx                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Hyperplasia                          |                                                                          |      1  1.0|
      Inflammation, Chronic Active         |                                                                          |      3  1.7|
      Metaplasia, Squamous                 |                         1  1                 1     1              3      |     11  1.5|
      Epiglottis, Hyperplasia              |                         2                                                |      3  1.7|
      Epiglottis, Metaplasia, Squamous     |                                                                   3      |      3  2.3|

                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia, Atypical                |       3     1                 2  2           2  1        2  3     3  2  2|     16  2.2|
      Inflammation, Chronic Active         | 4  4  4  4  4  4  4  2  4  4  4  4  4  4  3  4  4  4  4  4  4  4  4  4  4|     50  3.7|
      Metaplasia, Squamous                 |                                                                          |      1  2.0|
      Mineralization                       |                                                                          |      1  4.0|
      Proteinosis                          | 4  4  4  4  4  4  4  4  4  4  4  4  4  4     4  4  4  4  4  4  4  4  4  4|     49  3.8|
      Alveolar Epithelium, Hyperplasia     |       3  1                 2           1  2        2  2           3      |     14  2.3|
      Alveolar Epithelium, Metaplasia      |       2  3  2           3  3  3  3     2     2  3  4  3  3  3  4  3  3  3|     41  2.6|
      Artery, Mediastinum, Mineralization  |                                                                          |      1  4.0|

 __________________________________________________________________________________________________________________________________ 

  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
NTP Experiment-Test: 05180-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          GALLIUM ARSENIDE                                     Date: 02/17/99  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 08:17:39  
                                                                                                                                    

 __________________________________________________________________________________________________________________________________ 
                                           | 3| 2| 7| 6| 7| 4| 6| 2| 6| 6| 7| 5| 4| 5| 5| 4| 7| 7| 6| 7| 7| 7| 6| 5| 7|            |
                             DAY ON TEST   | 1| 5| 1| 7| 3| 1| 9| 1| 7| 8| 3| 6| 7| 1| 0| 7| 3| 3| 9| 0| 3| 3| 8| 9| 1|            |
                                           | 0| 4| 2| 4| 4| 8| 1| 5| 7| 4| 4| 4| 8| 9| 6| 6| 4| 5| 6| 3| 4| 5| 8| 4| 6|      T (*) |

 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|      A     |
    1.0                                    | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      L     |
    MG/M3                                  | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |

 __________________________________________________________________________________________________________________________________ 
 RESPIRATORY SYSTEM - cont                 |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Inflammation, Suppurative            |                                                                   2     2|      3  2.0|
      Thrombosis                           |                                        2     1           4               |      6  2.7|
      Olfactory Epithelium, Atrophy        |                                                                          |      2  1.5|
      Olfactory Epithelium, Degeneration,  |                                                                          |            |
           Hyaline                         |       1  2  1  2        2  2  1  2  2  2     2  1        2  1     2      |     32  1.6|
      Olfactory Epithelium, Metaplasia,    |                                                                          |            |
           Respiratory                     |                                                                          |      1  3.0|

                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Mineralization                       |                                                                          |      1  3.0|

 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Ear                                     |                                                             +            |   1        |

                                            __________________________________________________________________________|____________|
   Eye                                     |                                                                          |   1        |
      Cataract                             |                                                                          |      1  3.0|
      Retina, Atrophy                      |                                                                          |      1  3.0|

 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Angiectasis                          |                   4                                                      |      1  4.0|
      Infarct                              |                                                                          |      1  2.0|
      Mineralization                       |                                                                          |      1  3.0|
      Nephropathy                          | 1     2  2  4  2  4  1  4  2  3  3  1  1  1     3  3  2  2  3  2  3  2  2|     45  2.4|
      Thrombosis                           |                   4                                                      |      1  4.0|
      Renal Tubule, Hyperplasia            |             2                                                            |      2  1.5|

                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +|  49        |

 __________________________________________________________________________________________________________________________________ 

  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
NTP Experiment-Test: 05180-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          GALLIUM ARSENIDE                                     Date: 02/17/99  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 08:17:39  
                                                                                                                                    

 _____________________________________________________________________________________________________________________              
                                           | 6| 6| 7| 7| 5| 7| 5| 7| 5| 7| 6| 6| 6| 5| 7| 6| 6| 6| 6| 7| 7| 7| 3| 5| 5|             
                             DAY ON TEST   | 4| 8| 3| 3| 6| 3| 3| 3| 9| 2| 8| 6| 1| 0| 3| 4| 6| 7| 8| 3| 3| 3| 3| 6| 9|             
                                           | 2| 1| 3| 3| 6| 3| 4| 3| 0| 6| 8| 2| 2| 6| 3| 5| 2| 1| 5| 3| 3| 3| 8| 7| 9|             

 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    CONTROL                                | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             

 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Acute                  |                                                          1               |             

                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Acute                  |                                                                          |             

                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +|             

                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  A|             
      Inflammation, Granulomatous          |                                                                          |             
      Mineralization                       |                                                                          |             

                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Basophilic Focus                     |    X  X  X     X     X  X  X  X  X        X        X  X  X     X     X   |             
      Clear Cell Focus                     |       X  X           X                                      X            |             
      Degeneration, Cystic                 |    2        2                                               2           2|             
      Eosinophilic Focus                   |                X                             X  X                        |             
      Fatty Change                         |             1                                                            |             
      Hepatodiaphragmatic Nodule           |                                                                          |             
      Inflammation, Granulomatous          |                                                                          |             
      Mixed Cell Focus                     |                                                          X               |             
      Necrosis                             |                         1                                                |             
      Regeneration                         |                                                                          |             
      Vacuolization Cytoplasmic, Focal     |                            3                                             |             
      Bile Duct, Hyperplasia               | 2        2     2  1        1  2     2     1  1  3     2  2               |             
      Centrilobular, Necrosis              | 2                                1     1     1  2     2              1  3|             

                                            __________________________________________________________________________|             
   Mesentery                               |                                                                          |             
      Artery, Mineralization               |                                                                          |             
      Fat, Necrosis                        |                                                                          |             

                                            __________________________________________________________________________|             
   Oral Mucosa                             |                         +                                                |             
      Pharyngeal, Inflammation, Chronic    |                         3                                                |             

                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |    2  2  3     2        2  1     3        1  1  3     2  2           2   |             
      Basophilic Focus                     |       X     X        X                                                   |             
      Hyperplasia                          |                2                                                         |             
      Artery, Inflammation                 |                                                                          |             
      Artery, Mineralization               |                                                                          |             

                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                      2                                                   |             
      Artery, Mineralization               |                                                                          |             

                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Mineralization                       |                                                                          |             
      Necrosis                             |                                  4              2                        |             

                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Acute                  |                                                                          |             

 _____________________________________________________________________________________________________________________|             
NTP Experiment-Test: 05180-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          GALLIUM ARSENIDE                                     Date: 02/17/99  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 08:17:39  
                                                                                                                                    

 _____________________________________________________________________________________________________________________              
                                           | 6| 6| 7| 7| 5| 7| 5| 7| 5| 7| 6| 6| 6| 5| 7| 6| 6| 6| 6| 7| 7| 7| 3| 5| 5|             
                             DAY ON TEST   | 4| 8| 3| 3| 6| 3| 3| 3| 9| 2| 8| 6| 1| 0| 3| 4| 6| 7| 8| 3| 3| 3| 3| 6| 9|             
                                           | 2| 1| 3| 3| 6| 3| 4| 3| 0| 6| 8| 2| 2| 6| 3| 5| 2| 1| 5| 3| 3| 3| 8| 7| 9|             

 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    CONTROL                                | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             

 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
                                           |                                                                          |             
      Mineralization                       |    1                                                           1         |             
      Necrosis                             |                                              1                           |             

                                            __________________________________________________________________________|             
   Tongue                                  |                                  +     +                                 |             

                                            __________________________________________________________________________|             
   Tooth                                   |                         +                                                |             
      Developmental Malformation           |                         X                                                |             
      Inflammation, Chronic Active         |                         3                                                |             

 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Blood Vessel                            |                                                                          |             
      Aorta, Mineralization                |                                                                          |             

                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cardiomyopathy                       | 1  2  2  2  2  2  2  2  2  3  2     2  1  2     3  3  2     3  2     1  3|             
      Artery, Mineralization               |                                                                          |             
      Atrium, Thrombosis                   |                                                 3                       4|             

 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                                                                          |             
      Hyperplasia                          | 2  2  2  2  2     2  2  1     1        2  2     2  2     2  2  2         |             
      Hypertrophy                          |                                                       2                  |             
      Necrosis                             |                                              2                           |             
      Vacuolization Cytoplasmic            |                                                                          |             

                                            __________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          | 2  2  1        2  2                    3     2  4     3     3  3         |             

                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                                                          |             

                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  I  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                   3                                2                     |             

                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Pars Distalis, Hyperplasia           |       4     3           2           3        2     4     3  3  2     3  3|             

                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  A|             
      Hyperplasia                          |                                                             3            |             
      C-Cell, Hyperplasia                  |       1  2  1  2  1  3  1  1  3  1                 3  2  1     2  1      |             

 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Peritoneum                              |                                                                         +|             

 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

                                            __________________________________________________________________________|             
   Penis                                   |                   +                                                      |             

                                            __________________________________________________________________________|             
   Preputial Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                                                          |             
      Inflammation, Chronic Active         |       2                                                                  |             

                                            __________________________________________________________________________|             
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

 _____________________________________________________________________________________________________________________|             
NTP Experiment-Test: 05180-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          GALLIUM ARSENIDE                                     Date: 02/17/99  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 08:17:39  
                                                                                                                                    

 _____________________________________________________________________________________________________________________              
                                           | 6| 6| 7| 7| 5| 7| 5| 7| 5| 7| 6| 6| 6| 5| 7| 6| 6| 6| 6| 7| 7| 7| 3| 5| 5|             
                             DAY ON TEST   | 4| 8| 3| 3| 6| 3| 3| 3| 9| 2| 8| 6| 1| 0| 3| 4| 6| 7| 8| 3| 3| 3| 3| 6| 9|             
                                           | 2| 1| 3| 3| 6| 3| 4| 3| 0| 6| 8| 2| 2| 6| 3| 5| 2| 1| 5| 3| 3| 3| 8| 7| 9|             

 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    CONTROL                                | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             

 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
      Hyperplasia                          |    2  3              3           1        2     1           2  4         |             
      Inflammation, Chronic Active         |                                                                          |             
      Mineralization                       |                                                                          |             

                                            __________________________________________________________________________|             
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +|             
      Mineralization                       |                                                                          |             

                                            __________________________________________________________________________|             
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                                                                          |             
      Artery, Inflammation, Chronic Active |                                                                          |             
      Interstitial Cell, Hyperplasia       |                                                                          |             

 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

                                            __________________________________________________________________________|             
   Lymph Node                              |                   +           +  +     +              +                  |             
      Hemorrhage                           |                   2                                                      |             
      Renal, Ectasia                       |                               2                                          |             
      Renal, Hemorrhage                    |                                                                          |             

                                            __________________________________________________________________________|             
   Lymph Node, Bronchial                   | M  +  +  +  +  M  +  +  +  +  +  +  +  +  M  M  M  M  M  M  +  +  +  +  M|             

                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +|             
      Infiltration Cellular, Plasma Cell   |                         4              4                                 |             
      Infiltration Cellular,               |                                                                          |             
          Polymorphonuclear                |                                                                          |             

                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |                                                                          |             

                                            __________________________________________________________________________|             
   Lymph Node, Mediastinal                 | +  +  M  M  +  M  +  +  M  +  +  +  +  +  +  +  +  M  +  M  +  +  +  +  +|             
      Hemorrhage                           |                                        2                                 |             

                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Congestion                           |                3                                                         |             
      Fibrosis                             | 2     2                    2           3     2        2  2  2        2   |             
      Hematopoietic Cell Proliferation     |             2              2                                            3|             
      Inflammation, Granulomatous          |                2                       4                                 |             
      Thrombosis                           |                                        3                                 |             

                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  M  +  +  +  +  +  +  +|             
      Cyst                                 |                                                                          |             

 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Mammary Gland                           | +  M  +  M  +  M  +  +  +  +  +  +  +  +  +  M  M  +  M  +  +  +  +  +  +|             
      Galactocele                          |                                                                          |             

                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperkeratosis                       |       3                                                                  |             

 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrous Osteodystrophy               |                   3                                                      |             

                                            __________________________________________________________________________|             
   Skeletal Muscle                         |                                        +                                 |             

 _____________________________________________________________________________________________________________________|             
NTP Experiment-Test: 05180-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          GALLIUM ARSENIDE                                     Date: 02/17/99  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 08:17:39  
                                                                                                                                    

 _____________________________________________________________________________________________________________________              
                                           | 6| 6| 7| 7| 5| 7| 5| 7| 5| 7| 6| 6| 6| 5| 7| 6| 6| 6| 6| 7| 7| 7| 3| 5| 5|             
                             DAY ON TEST   | 4| 8| 3| 3| 6| 3| 3| 3| 9| 2| 8| 6| 1| 0| 3| 4| 6| 7| 8| 3| 3| 3| 3| 6| 9|             
                                           | 2| 1| 3| 3| 6| 3| 4| 3| 0| 6| 8| 2| 2| 6| 3| 5| 2| 1| 5| 3| 3| 3| 8| 7| 9|             

 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    CONTROL                                | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             

 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM - cont             |                                                                          |             
                                           |                                                                          |             

 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Degeneration                         |                                  2                                       |             

 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Larynx                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |          2                                                               |             
      Inflammation, Chronic Active         |          2                                                               |             
      Metaplasia, Squamous                 |                                                                          |             
      Mineralization                       |                                                                          |             

                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |                                                                          |             
      Inflammation, Chronic Active         |          1                                1                              |             
      Mineralization                       |                                                                          |             
      Thrombosis                           |                                                                          |             
      Alveolar Epithelium, Hyperplasia     |    1     1     3     1     2              4     3           4            |             
      Artery, Mediastinum, Mineralization  |                                                                          |             

                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Suppurative            |          2        2  1                                                   |             
      Thrombosis                           |                                              3                       3  4|             
      Olfactory Epithelium, Atrophy        |                               1                                          |             
      Olfactory Epithelium, Degeneration,  |                                                                          |             
           Hyaline                         |       1  2  1        2           2  1                    2     1     1   |             
      Olfactory Epithelium, Metaplasia,    |                                                                          |             
           Respiratory                     |                   2           1                                          |             

                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Mineralization                       |                                                                          |             

 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Ear                                     |       +                                                                  |             

                                            __________________________________________________________________________|             
   Eye                                     |                            +                    +     +                  |             
      Cataract                             |                            3                    4     4                  |             
      Retina, Atrophy                      |                            3                    4     4                  |             

                                            __________________________________________________________________________|             
   Zymbal's Gland                          |                                                                          |             

 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                                                          |             
      Mineralization                       |                                                                          |             
      Nephropathy                          | 2  2  3  3  2  3  4  3  4  3  4  3  2  2  2  2  3  4  4  3  4  3  2  3  3|             
      Renal Tubule, Hyperplasia            |                                                    2                     |             

                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic Active         |                                                                          |             
      Transitional Epithelium, Hyperplasia |                                                                          |             

 _____________________________________________________________________________________________________________________|             


                                                             Page  37                                                               
NTP Experiment-Test: 05180-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          GALLIUM ARSENIDE                                     Date: 02/17/99  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 08:17:39  
                                                                                                                                    

 __________________________________________________________________________________________________________________________________ 
                                           | 7| 6| 6| 6| 7| 7| 6| 6| 5| 6| 6| 7| 7| 7| 6| 6| 7| 7| 5| 5| 5| 6| 6| 5| 5|            |
                             DAY ON TEST   | 3| 5| 1| 3| 3| 2| 1| 4| 6| 7| 2| 3| 3| 3| 2| 9| 1| 2| 9| 6| 4| 8| 8| 4| 3|            |
                                           | 3| 8| 7| 6| 3| 0| 2| 7| 6| 7| 1| 3| 3| 3| 1| 3| 3| 9| 0| 7| 5| 5| 4| 4| 4|      T (*) |

 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      A     |
    CONTROL                                | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |

 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |

                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  A  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +|  47        |

                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +|  48        |
      Inflammation, Acute                  |                                                                          |      1  1.0|

                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  A  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  A  +  +|  46        |
      Inflammation, Acute                  |                      3                                                   |      1  3.0|

                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +|  48        |

                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  A  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  A  +  +|  45        |

                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  A  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  A  +  +|  44        |
      Inflammation, Granulomatous          |                                                       2                  |      1  2.0|
      Mineralization                       |                      2                                                   |      1  2.0|

                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Basophilic Focus                     | X     X     X                          X                 X              X|     21     |
      Clear Cell Focus                     | X                                X                                       |      6     |
      Degeneration, Cystic                 |    2  2     4              2     1                    2                  |     10  2.1|
      Eosinophilic Focus                   |    X                       X     X                                       |      6     |
      Fatty Change                         |                                           2           1           2  3   |      5  1.8|
      Hepatodiaphragmatic Nodule           | X                                                                        |      1     |
      Inflammation, Granulomatous          |                      1                                                   |      1  1.0|
      Mixed Cell Focus                     |                                                                          |      1     |
      Necrosis                             |                                           3                              |      2  2.0|
      Regeneration                         |                                                    3                     |      1  3.0|
      Vacuolization Cytoplasmic, Focal     |                                                                          |      1  3.0|
      Bile Duct, Hyperplasia               | 1  3  1  3  1  1  2     1  4           2           3     1  1  2     1  2|     28  1.8|
      Centrilobular, Necrosis              |          2                                         1        1  1        2|     13  1.5|

                                            __________________________________________________________________________|____________|
   Mesentery                               |                +     +                    +  +                    +      |   5        |
      Artery, Mineralization               |                3     4                                            4      |      3  3.7|
      Fat, Necrosis                        |                      3                    2  2                           |      3  2.3|

                                            __________________________________________________________________________|____________|
   Oral Mucosa                             |                                                                          |   1        |
      Pharyngeal, Inflammation, Chronic    |                                                                          |      1  3.0|

                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Atrophy                              |          2  2  2        1  1  1     2  2  1        3     1               |     24  1.8|
      Basophilic Focus                     |                                                                          |      3     |
      Hyperplasia                          |                                  3              2  2                     |      4  2.3|
      Artery, Inflammation                 |                4                                                  4      |      2  4.0|
      Artery, Mineralization               |                4     2                                            3      |      3  3.0|

                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Atrophy                              |                                                                          |      1  2.0|
      Artery, Mineralization               |                      2                                                   |      1  2.0|

 __________________________________________________________________________________________________________________________________ 

  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
NTP Experiment-Test: 05180-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          GALLIUM ARSENIDE                                     Date: 02/17/99  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 08:17:39  
                                                                                                                                    

 __________________________________________________________________________________________________________________________________ 
                                           | 7| 6| 6| 6| 7| 7| 6| 6| 5| 6| 6| 7| 7| 7| 6| 6| 7| 7| 5| 5| 5| 6| 6| 5| 5|            |
                             DAY ON TEST   | 3| 5| 1| 3| 3| 2| 1| 4| 6| 7| 2| 3| 3| 3| 2| 9| 1| 2| 9| 6| 4| 8| 8| 4| 3|            |
                                           | 3| 8| 7| 6| 3| 0| 2| 7| 6| 7| 1| 3| 3| 3| 1| 3| 3| 9| 0| 7| 5| 5| 4| 4| 4|      T (*) |

 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      A     |
    CONTROL                                | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |

 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Mineralization                       |                3     4                                                   |      2  3.5|
      Necrosis                             |          2  2                             4     4                    4   |      7  3.1|

                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Inflammation, Acute                  |                                                 3                        |      1  3.0|
      Mineralization                       |                3     4           1              2     3           4      |      8  2.4|
      Necrosis                             |             2                                   3                       3|      4  2.3|

                                            __________________________________________________________________________|____________|
   Tongue                                  |                                                                          |   2        |

                                            __________________________________________________________________________|____________|
   Tooth                                   |             +                                                            |   2        |
      Developmental Malformation           |             X                                                            |      2     |
      Inflammation, Chronic Active         |                                                                          |      1  3.0|

 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Blood Vessel                            |                      +                                +           +      |   3        |
      Aorta, Mineralization                |                      4                                3           4      |      3  3.7|

                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cardiomyopathy                       | 2  2  1  3  1  4  3  4  2  1  2  2  2  2  2  2  3  3  4  2     3  4  2   |     44  2.3|
      Artery, Mineralization               |                4     4                          1     3           4      |      5  3.2|
      Atrium, Thrombosis                   |          3                                                        3      |      4  3.3|

 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Adrenal Cortex                          | +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Atrophy                              |                3                                                         |      1  3.0|
      Hyperplasia                          | 2           2                 2  2     2     2           2     2         |     24  1.9|
      Hypertrophy                          |                                                                          |      1  2.0|
      Necrosis                             |                                                                          |      1  2.0|
      Vacuolization Cytoplasmic            |                                           4     2                        |      2  3.0|

                                            __________________________________________________________________________|____________|
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia                          | 3     1     1        3     3                 3  3  2  3  1     4         |     22  2.5|

                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Hyperplasia                          |                                           2                              |      1  2.0|

                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  M  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +|  47        |
      Hyperplasia                          |             2  4     4     2  2  3        1     3     3           4  2   |     13  2.7|

                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +|  49        |
      Pars Distalis, Hyperplasia           | 4        2     2     1        3     1                                    |     17  2.6|

                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +|  46        |
      Hyperplasia                          |                                                                          |      1  3.0|
      C-Cell, Hyperplasia                  |       1     1              1  1     1  1  1  1  1              2     1   |     26  1.4|

 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |

 __________________________________________________________________________________________________________________________________ 

  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
NTP Experiment-Test: 05180-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          GALLIUM ARSENIDE                                     Date: 02/17/99  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 08:17:39  
                                                                                                                                    

 __________________________________________________________________________________________________________________________________ 
                                           | 7| 6| 6| 6| 7| 7| 6| 6| 5| 6| 6| 7| 7| 7| 6| 6| 7| 7| 5| 5| 5| 6| 6| 5| 5|            |
                             DAY ON TEST   | 3| 5| 1| 3| 3| 2| 1| 4| 6| 7| 2| 3| 3| 3| 2| 9| 1| 2| 9| 6| 4| 8| 8| 4| 3|            |
                                           | 3| 8| 7| 6| 3| 0| 2| 7| 6| 7| 1| 3| 3| 3| 1| 3| 3| 9| 0| 7| 5| 5| 4| 4| 4|      T (*) |

 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      A     |
    CONTROL                                | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |

 __________________________________________________________________________________________________________________________________ 
 GENERAL BODY SYSTEM - cont                |                                                                          |            |
                                           |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Peritoneum                              |                                                                          |   1        |

 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |

                                            __________________________________________________________________________|____________|
   Penis                                   |                                                                          |   1        |

                                            __________________________________________________________________________|____________|
   Preputial Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia                          |          1                                                               |      1  1.0|
      Inflammation, Chronic Active         |                4     3                          4                        |      4  3.3|

                                            __________________________________________________________________________|____________|
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia                          |    2        2                 2                    3                     |     12  2.3|
      Inflammation, Chronic Active         | 2                                                  3              2      |      3  2.3|
      Mineralization                       |                      3                                                   |      1  3.0|

                                            __________________________________________________________________________|____________|
   Seminal Vesicle                         | +  A  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  A  +  +|  45        |
      Mineralization                       |                3     2                                                   |      2  2.5|

                                            __________________________________________________________________________|____________|
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Atrophy                              |                                        3                                 |      1  3.0|
      Artery, Inflammation, Chronic Active |       3                                3                             2   |      3  2.7|
      Interstitial Cell, Hyperplasia       |       1                 2                                                |      2  1.5|

 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |

                                            __________________________________________________________________________|____________|
   Lymph Node                              |                            +        +           +  +        +  +        +|  12        |
      Hemorrhage                           |                                                                          |      1  2.0|
      Renal, Ectasia                       |                                                                          |      1  2.0|
      Renal, Hemorrhage                    |                                                 1                        |      1  1.0|

                                            __________________________________________________________________________|____________|
   Lymph Node, Bronchial                   | +  +  +  +  M  +  M  +  M  +  +  +  +  +  +  +  +  +  M  +  +  +  M  +  +|  36        |

                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +|  46        |
      Infiltration Cellular, Plasma Cell   |                                                                          |      2  4.0|
      Infiltration Cellular,               |                                                                          |            |
          Polymorphonuclear                |                2                                                         |      1  2.0|

                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +|  48        |
      Hemorrhage                           |                2                                                         |      1  2.0|

                                            __________________________________________________________________________|____________|
   Lymph Node, Mediastinal                 | +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +|  42        |
      Hemorrhage                           |                                                                          |      1  2.0|

                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Congestion                           |                                                                          |      1  3.0|
      Fibrosis                             |                      2                 2           3                    2|     13  2.2|
      Hematopoietic Cell Proliferation     |                      3                                                   |      4  2.5|

 __________________________________________________________________________________________________________________________________ 

  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
NTP Experiment-Test: 05180-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          GALLIUM ARSENIDE                                     Date: 02/17/99  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 08:17:39  
                                                                                                                                    

 __________________________________________________________________________________________________________________________________ 
                                           | 7| 6| 6| 6| 7| 7| 6| 6| 5| 6| 6| 7| 7| 7| 6| 6| 7| 7| 5| 5| 5| 6| 6| 5| 5|            |
                             DAY ON TEST   | 3| 5| 1| 3| 3| 2| 1| 4| 6| 7| 2| 3| 3| 3| 2| 9| 1| 2| 9| 6| 4| 8| 8| 4| 3|            |
                                           | 3| 8| 7| 6| 3| 0| 2| 7| 6| 7| 1| 3| 3| 3| 1| 3| 3| 9| 0| 7| 5| 5| 4| 4| 4|      T (*) |

 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      A     |
    CONTROL                                | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |

 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
      Inflammation, Granulomatous          |                                                                          |      2  3.0|
      Thrombosis                           |                                                                          |      1  3.0|

                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +|  46        |
      Cyst                                 |                2                                                         |      1  2.0|

 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  M  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  M  +  +  +  +|  41        |
      Galactocele                          |                                                                      3   |      1  3.0|

                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperkeratosis                       |                                                                          |      1  3.0|

 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Fibrous Osteodystrophy               |             2  4     4           1              2     4           4      |      8  3.0|

                                            __________________________________________________________________________|____________|
   Skeletal Muscle                         |                                                                          |   1        |

 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Degeneration                         |                                                                          |      1  2.0|

 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Larynx                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia                          |                                                 2                 2      |      3  2.0|
      Inflammation, Chronic Active         |                                                 1     1           2      |      4  1.5|
      Metaplasia, Squamous                 |                                                                   2      |      1  2.0|
      Mineralization                       |                2                                                         |      1  2.0|

                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hemorrhage                           |                                                                   2      |      1  2.0|
      Inflammation, Chronic Active         |                                                          1               |      3  1.0|
      Mineralization                       |                3     4                                3           3      |      4  3.3|
      Thrombosis                           |                                                                   2      |      1  2.0|
      Alveolar Epithelium, Hyperplasia     |             1  1                                1        2               |     12  2.0|
      Artery, Mediastinum, Mineralization  |                4     4                                3           4      |      4  3.8|

                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inflammation, Suppurative            |          4     2  2                             2  1  3           3      |     10  2.2|
      Thrombosis                           |                                                    4                     |      4  3.5|
      Olfactory Epithelium, Atrophy        |                                                                          |      1  1.0|
      Olfactory Epithelium, Degeneration,  |                                                                          |            |
           Hyaline                         | 1  1  2                    1        1           1        1  2           2|     18  1.4|

 __________________________________________________________________________________________________________________________________ 

  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
NTP Experiment-Test: 05180-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          GALLIUM ARSENIDE                                     Date: 02/17/99  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 08:17:39  
                                                                                                                                    

 __________________________________________________________________________________________________________________________________ 
                                           | 7| 6| 6| 6| 7| 7| 6| 6| 5| 6| 6| 7| 7| 7| 6| 6| 7| 7| 5| 5| 5| 6| 6| 5| 5|            |
                             DAY ON TEST   | 3| 5| 1| 3| 3| 2| 1| 4| 6| 7| 2| 3| 3| 3| 2| 9| 1| 2| 9| 6| 4| 8| 8| 4| 3|            |
                                           | 3| 8| 7| 6| 3| 0| 2| 7| 6| 7| 1| 3| 3| 3| 1| 3| 3| 9| 0| 7| 5| 5| 4| 4| 4|      T (*) |

 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      A     |
    CONTROL                                | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |

 __________________________________________________________________________________________________________________________________ 
 RESPIRATORY SYSTEM - cont                 |                                                                          |            |
                                           |                                                                          |            |
      Olfactory Epithelium, Metaplasia,    |                                                                          |            |
           Respiratory                     |                                                                          |      2  1.5|

                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Mineralization                       |                2     3                                                   |      2  2.5|

 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Ear                                     |                                                                          |   1        |

                                            __________________________________________________________________________|____________|
   Eye                                     |                      +                                                   |   4        |
      Cataract                             |                      4                                                   |      4  3.8|
      Retina, Atrophy                      |                      3                                                   |      4  3.5|

                                            __________________________________________________________________________|____________|
   Zymbal's Gland                          |                               +                                          |   1        |

 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Cyst                                 |                      2           2                    2                  |      3  2.0|
      Mineralization                       |                3     3                    1           3           3      |      5  2.6|
      Nephropathy                          | 3  2  4  2  4  4     4  2  4  3  4  3  4  4  3  4  4  4  2  2  3  4  3   |     48  3.1|
      Renal Tubule, Hyperplasia            |             3                                                            |      2  2.5|

                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  A  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Inflammation, Chronic Active         |                                              3                           |      1  3.0|
      Transitional Epithelium, Hyperplasia |                                              4                           |      1  4.0|

 __________________________________________________________________________________________________________________________________ 

  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
NTP Experiment-Test: 05180-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          GALLIUM ARSENIDE                                     Date: 02/17/99  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 08:17:39  
                                                                                                                                    

 _____________________________________________________________________________________________________________________              
                                           | 3| 5| 7| 7| 6| 6| 7| 7| 6| 7| 5| 5| 7| 7| 5| 6| 5| 6| 5| 6| 2| 7| 6| 5| 3|             
                             DAY ON TEST   | 5| 7| 0| 3| 2| 6| 1| 0| 4| 3| 3| 8| 3| 3| 4| 4| 9| 8| 6| 1| 0| 3| 9| 3| 9|             
                                           | 0| 4| 9| 3| 1| 0| 2| 8| 7| 3| 2| 6| 3| 3| 8| 7| 0| 4| 6| 4| 4| 3| 1| 4| 3|             

 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    0.01                                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
    MG/M3                                  | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             

 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  A  +  +  +  +|             
      Mineralization                       |             2                                                            |             

                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Mineralization                       |                      2                                                   |             

                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | A  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  A  +  +  +  +|             
      Inflammation, Acute                  |                                                                          |             
      Mineralization                       |                2     2                                                   |             
      Necrosis                             |       2                                                                  |             

                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Acute                  |                                                                          |             

                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | A  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  A  +  +  +  +|             

                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | A  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  A  +  +  +  +|             

                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                            3        2                                    |             
      Basophilic Focus                     |          X  X  X  X  X              X           X  X     X     X         |             
      Clear Cell Focus                     |                                        X                       X         |             
      Degeneration, Cystic                 |       2  1  1              2           4                                 |             
      Eosinophilic Focus                   |                X                             X                           |             
      Fatty Change                         | 2                    1  2                                                |             
      Hepatodiaphragmatic Nodule           |                                                                          |             
      Regeneration                         |             2                    4                    4                  |             
      Bile Duct, Hyperplasia               |    2  3  1  1     3        2     3  1  3  3           2  3        2      |             
      Centrilobular, Necrosis              | 1  1              2           3  2                    2           1  3  1|             

                                            __________________________________________________________________________|             
   Mesentery                               |       +        +     +                                +                 +|             
      Hemorrhage                           |                                                                         4|             
      Artery, Inflammation, Chronic Active |                                                                          |             
      Artery, Mineralization               |                3     4                                                   |             
      Fat, Necrosis                        |       2              2                                3                  |             

                                            __________________________________________________________________________|             
   Oral Mucosa                             |             +                                                  +         |             

                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |       2  2  1     2        2  2     3  2  2        1     1        2  1   |             
      Basophilic Focus                     |          X     X                                                         |             
      Hyperplasia                          |                2     4              2                                    |             
      Artery, Mineralization               |                      3                                                   |             

                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Mineralization                       |                2     2                                                   |             
      Necrosis                             |    1              3     4     3  2           3                          2|             

                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Mineralization                       |             2  3     4     2                                             |             
      Necrosis                             |    1              3           3  2                                   2  1|             

                                            __________________________________________________________________________|             
   Tooth                                   |                                                                          |             
      Developmental Malformation           |                                                                          |             

 _____________________________________________________________________________________________________________________|             
NTP Experiment-Test: 05180-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          GALLIUM ARSENIDE                                     Date: 02/17/99  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 08:17:39  
                                                                                                                                    

 _____________________________________________________________________________________________________________________              
                                           | 3| 5| 7| 7| 6| 6| 7| 7| 6| 7| 5| 5| 7| 7| 5| 6| 5| 6| 5| 6| 2| 7| 6| 5| 3|             
                             DAY ON TEST   | 5| 7| 0| 3| 2| 6| 1| 0| 4| 3| 3| 8| 3| 3| 4| 4| 9| 8| 6| 1| 0| 3| 9| 3| 9|             
                                           | 0| 4| 9| 3| 1| 0| 2| 8| 7| 3| 2| 6| 3| 3| 8| 7| 0| 4| 6| 4| 4| 3| 1| 4| 3|             

 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    0.01                                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
    MG/M3                                  | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             

 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
                                           |                                                                          |             

 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Blood Vessel                            |                +     +                                                   |             
      Aorta, Mineralization                |                3     4                                                   |             

                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cardiomyopathy                       |    1     3  1  3  2  3  2  3        2  2  2        2  2  2     1         |             
      Artery, Mineralization               |                3     4                                                   |             
      Atrium, Thrombosis                   |                                                                          |             

 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |       2  2  2  2     2              2  2  2  2     2           2  2      |             
      Hypertrophy                          |                                                                          |             
      Mineralization                       |                                                                          |             
      Vacuolization Cytoplasmic            |                   2        3                                            2|             

                                            __________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |    2  3  2  2  4     2  3  3  3  3        3     2  3           2     3   |             
      Bilateral, Hyperplasia               |                                                                          |             

                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                              3                           |             

                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |             3  4     3  1  3        2        2                           |             

                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                                                          |             
      Pars Distalis, Hyperplasia           |                                        4  2     1     2           3      |             

                                            __________________________________________________________________________|             
   Thyroid Gland                           | A  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      C-Cell, Hyperplasia                  |       1  1              1  1  1     2  1  2  1  1  2  1           1  1   |             
      Follicular Cell, Hyperplasia         |                                                                          |             

 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             

 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Coagulating Gland                       |             +                                                            |             
      Hyperplasia, Atypical                |             3                                                            |             

                                            __________________________________________________________________________|             
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

                                            __________________________________________________________________________|             
   Preputial Gland                         | +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic Active         |                                                                          |             

                                            __________________________________________________________________________|             
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +|             
      Hyperplasia                          |                                     2     3        1                     |             
      Inflammation, Chronic Active         |                               4                                          |             

                                            __________________________________________________________________________|             
   Seminal Vesicle                         | A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Mineralization                       |                      2                                                   |             

                                            __________________________________________________________________________|             
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

 _____________________________________________________________________________________________________________________|             
NTP Experiment-Test: 05180-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          GALLIUM ARSENIDE                                     Date: 02/17/99  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 08:17:39  
                                                                                                                                    

 _____________________________________________________________________________________________________________________              
                                           | 3| 5| 7| 7| 6| 6| 7| 7| 6| 7| 5| 5| 7| 7| 5| 6| 5| 6| 5| 6| 2| 7| 6| 5| 3|             
                             DAY ON TEST   | 5| 7| 0| 3| 2| 6| 1| 0| 4| 3| 3| 8| 3| 3| 4| 4| 9| 8| 6| 1| 0| 3| 9| 3| 9|             
                                           | 0| 4| 9| 3| 1| 0| 2| 8| 7| 3| 2| 6| 3| 3| 8| 7| 0| 4| 6| 4| 4| 3| 1| 4| 3|             

 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    0.01                                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
    MG/M3                                  | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             

 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
      Atrophy                              |                                                                          |             
      Artery, Inflammation, Chronic Active |                         3                    2                           |             
      Interstitial Cell, Hyperplasia       |                               2                                         2|             

 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

                                            __________________________________________________________________________|             
   Lymph Node                              |    +              +           +                                   +     +|             
      Renal, Infiltration Cellular, Plasma |                                                                          |             
          Cell                             |                                                                          |             

                                            __________________________________________________________________________|             
   Lymph Node, Bronchial                   | M  +  +  +  M  +  +  +  +  M  +  +  +  +  +  M  +  M  +  +  +  M  +  +  +|             

                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | M  +  +  +  +  +  +  +  +  +  +  +  +  M  +  M  +  +  +  +  +  +  +  +  +|             
      Infiltration Cellular, Plasma Cell   |                                                                          |             

                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

                                            __________________________________________________________________________|             
   Lymph Node, Mediastinal                 | M  +  +  +  +  +  +  +  +  +  +  +  M  +  +  M  M  +  +  +  +  M  +  +  +|             

                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrosis                             |    2              2  2              2                    2        2      |             
      Hematopoietic Cell Proliferation     |                                                                      3   |             
      Hyperplasia                          |                                                                          |             
      Necrosis                             |                                                                          |             

                                            __________________________________________________________________________|             
   Thymus                                  | +  +  M  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +|             

 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Mammary Gland                           | A  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  M  +  +  +|             
      Galactocele                          |    2                                                                     |             

                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  I  +  +  +  +  +  +|             

 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Callus                               |                                                             4            |             
      Fibrous Osteodystrophy               |             3  3     4     2                 1                           |             

 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Gliosis                              |                                                                          |             

                                            __________________________________________________________________________|             
   Peripheral Nerve                        |                                                             +            |             

 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Larynx                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |          1  1        1                       1                           |             
      Inflammation, Chronic Active         |          2  1        1                                                   |             
      Metaplasia, Squamous                 |             1                                                            |             
      Epiglottis, Hyperplasia              |          2  1        1                       1                           |             
      Epiglottis, Inflammation, Chronic    |                                                                          |             
          Active                           |          2                                                               |             

 _____________________________________________________________________________________________________________________|             
NTP Experiment-Test: 05180-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          GALLIUM ARSENIDE                                     Date: 02/17/99  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 08:17:39  
                                                                                                                                    

 _____________________________________________________________________________________________________________________              
                                           | 3| 5| 7| 7| 6| 6| 7| 7| 6| 7| 5| 5| 7| 7| 5| 6| 5| 6| 5| 6| 2| 7| 6| 5| 3|             
                             DAY ON TEST   | 5| 7| 0| 3| 2| 6| 1| 0| 4| 3| 3| 8| 3| 3| 4| 4| 9| 8| 6| 1| 0| 3| 9| 3| 9|             
                                           | 0| 4| 9| 3| 1| 0| 2| 8| 7| 3| 2| 6| 3| 3| 8| 7| 0| 4| 6| 4| 4| 3| 1| 4| 3|             

 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    0.01                                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
    MG/M3                                  | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             

 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |                                                                          |             
      Hyperplasia, Atypical                |                                        1                       4         |             
      Inflammation, Chronic Active         |    1  2  2  2  1  2  1  2  2        1  2  1  2  1  2  1  1     2  1  2  1|             
      Mineralization                       |             3  3     4                                                   |             
      Proteinosis                          |       1  1        1  1  1                    1     1           1        1|             
      Alveolar Epithelium, Hyperplasia     |                         2     3        1           1     1     1         |             
      Alveolar Epithelium, Metaplasia      |          1                                1                              |             
      Artery, Mediastinum, Mineralization  |                4     4                                                   |             

                                            __________________________________________________________________________|             
   Nose                                    | A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Suppurative            |                      2                          2                        |             
      Thrombosis                           |    3  2                          4        2           3           2      |             
      Olfactory Epithelium, Atrophy        |                                                          1               |             
      Olfactory Epithelium, Degeneration,  |                                                                          |             
           Hyaline                         |          1        2  2  1        1  1  1  2              1           1   |             
      Olfactory Epithelium, Metaplasia,    |                                                                          |             
           Respiratory                     |                                                          1               |             

                                            __________________________________________________________________________|             
   Pleura                                  |                                                                      +   |             

                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Eye                                     |                                                                      +   |             
      Cataract                             |                                                                      4   |             
      Retina, Atrophy                      |                                                                      4   |             

                                            __________________________________________________________________________|             
   Zymbal's Gland                          |                                                                          |             

 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |             2           2                                                |             
      Infarct                              |    2  2                                                                  |             
      Mineralization                       |                2     4                                                   |             
      Nephropathy                          | 2  2  3  4  4  4  3  4  4  4  2  2  4  3  2  4  3  3  2  4     4  3  3  2|             
      Renal Tubule, Hyperplasia            |                                              2                           |             

                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |                                                             4            |             

 _____________________________________________________________________________________________________________________|             
NTP Experiment-Test: 05180-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          GALLIUM ARSENIDE                                     Date: 02/17/99  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 08:17:39  
                                                                                                                                    

 __________________________________________________________________________________________________________________________________ 
                                           | 5| 3| 6| 5| 5| 5| 5| 7| 6| 7| 6| 6| 7| 7| 7| 6| 7| 7| 7| 7| 5| 7| 6| 6| 6|            |
                             DAY ON TEST   | 6| 0| 0| 2| 4| 9| 9| 3| 0| 3| 2| 2| 3| 1| 0| 5| 3| 3| 3| 3| 8| 3| 4| 9| 4|            |
                                           | 7| 6| 0| 4| 8| 0| 4| 3| 1| 3| 1| 5| 3| 9| 1| 5| 3| 3| 3| 3| 7| 3| 2| 9| 7|      T (*) |

 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|      A     |
    0.01                                   | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      L     |
    MG/M3                                  | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |

 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |

                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  47        |
      Mineralization                       |                                                                          |      1  2.0|

                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Mineralization                       |                                                                          |      1  2.0|

                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  A  A  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +|  43        |
      Inflammation, Acute                  |                                              4                           |      1  4.0|
      Mineralization                       |                                              3                           |      3  2.3|
      Necrosis                             |                                                                          |      1  2.0|

                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  A  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Inflammation, Acute                  |                         2                                                |      1  2.0|

                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  A  A  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +|  43        |

                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  A  A  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +|  43        |

                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Angiectasis                          |                                                                          |      2  2.5|
      Basophilic Focus                     | X           X        X     X        X     X  X     X  X  X     X     X  X|     23     |
      Clear Cell Focus                     |                                                 X                        |      3     |
      Degeneration, Cystic                 |                2     2                       1                       2   |      9  1.9|
      Eosinophilic Focus                   |                X                          X                              |      4     |
      Fatty Change                         |                         1              2  3                 2           1|      8  1.8|
      Hepatodiaphragmatic Nodule           |                                  X                 X                     |      2     |
      Regeneration                         |                                                                      3   |      4  3.3|
      Bile Duct, Hyperplasia               |       2  2     3           2     2     2  2  1        2  2  1     3  3  2|     27  2.1|
      Centrilobular, Necrosis              |    3  1        1                                                  2  2   |     14  1.8|

                                            __________________________________________________________________________|____________|
   Mesentery                               |          +                                            +  +        +     +|  10        |
      Hemorrhage                           |                                                                          |      1  4.0|
      Artery, Inflammation, Chronic Active |                                                          3               |      1  3.0|
      Artery, Mineralization               |                                                                          |      2  3.5|
      Fat, Necrosis                        |                                                       2  2        2     2|      7  2.1|

                                            __________________________________________________________________________|____________|
   Oral Mucosa                             |          +                                                               |   3        |

                                            __________________________________________________________________________|____________|
   Pancreas                                | +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Atrophy                              | 1           1  1  1  2     1     2  2           1  1  2  1     2  3  3  2|     29  1.7|
      Basophilic Focus                     |                                                          X               |      3     |
      Hyperplasia                          |                                                                          |      3  2.7|
      Artery, Mineralization               |                                                          2               |      2  2.5|

                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |

                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Mineralization                       |                                                                          |      2  2.0|
      Necrosis                             |       2  3                                   3                           |     10  2.6|

 __________________________________________________________________________________________________________________________________ 

  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
NTP Experiment-Test: 05180-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          GALLIUM ARSENIDE                                     Date: 02/17/99  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 08:17:39  
                                                                                                                                    

 __________________________________________________________________________________________________________________________________ 
                                           | 5| 3| 6| 5| 5| 5| 5| 7| 6| 7| 6| 6| 7| 7| 7| 6| 7| 7| 7| 7| 5| 7| 6| 6| 6|            |
                             DAY ON TEST   | 6| 0| 0| 2| 4| 9| 9| 3| 0| 3| 2| 2| 3| 1| 0| 5| 3| 3| 3| 3| 8| 3| 4| 9| 4|            |
                                           | 7| 6| 0| 4| 8| 0| 4| 3| 1| 3| 1| 5| 3| 9| 1| 5| 3| 3| 3| 3| 7| 3| 2| 9| 7|      T (*) |

 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|      A     |
    0.01                                   | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      L     |
    MG/M3                                  | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |

 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Mineralization                       |                                           3              3               |      6  2.8|
      Necrosis                             |       3  2                                                           1   |      9  2.0|

                                            __________________________________________________________________________|____________|
   Tooth                                   |                                                                         +|   1        |
      Developmental Malformation           |                                                                         X|      1     |

 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Blood Vessel                            |                                           +              +               |   4        |
      Aorta, Mineralization                |                                           3              3               |      4  3.3|

                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cardiomyopathy                       | 3     2     1  2  1  2  3  2  2  2  2     2  2  3  2  3  3  2  2  2  2  1|     37  2.1|
      Artery, Mineralization               |    3                                      4  2           3               |      6  3.2|
      Atrium, Thrombosis                   |       4                                                                  |      1  4.0|

 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Adrenal Cortex                          | +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Hyperplasia                          |             2  2  2  2     2        2     2  2  2     3        2        2|     24  2.0|
      Hypertrophy                          |                                                 2  2                 2   |      3  2.0|
      Mineralization                       |                                                       2                  |      1  2.0|
      Vacuolization Cytoplasmic            |                                  2     3                                 |      5  2.4|

                                            __________________________________________________________________________|____________|
   Adrenal Medulla                         | +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Hyperplasia                          |             2        3  2     2        1           1  2        2  2  3   |     25  2.4|
      Bilateral, Hyperplasia               | 4                                                                        |      1  4.0|

                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Hyperplasia                          |                                           2                              |      2  2.5|

                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Hyperplasia                          |    3                 3                    4  4  2        4               |     13  2.9|

                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Angiectasis                          |          2                                                               |      1  2.0|
      Pars Distalis, Hyperplasia           |             3  2           3     2  2        2  2                        |     12  2.3|

                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  A  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  46        |
      C-Cell, Hyperplasia                  |          1  1        1  2  1     1        1     2  2     1     1  1  3  1|     28  1.3|
      Follicular Cell, Hyperplasia         |                                     2                                    |      1  2.0|

 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |

 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Coagulating Gland                       |                                                                          |   1        |

 __________________________________________________________________________________________________________________________________ 

  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
NTP Experiment-Test: 05180-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          GALLIUM ARSENIDE                                     Date: 02/17/99  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 08:17:39  
                                                                                                                                    

 __________________________________________________________________________________________________________________________________ 
                                           | 5| 3| 6| 5| 5| 5| 5| 7| 6| 7| 6| 6| 7| 7| 7| 6| 7| 7| 7| 7| 5| 7| 6| 6| 6|            |
                             DAY ON TEST   | 6| 0| 0| 2| 4| 9| 9| 3| 0| 3| 2| 2| 3| 1| 0| 5| 3| 3| 3| 3| 8| 3| 4| 9| 4|            |
                                           | 7| 6| 0| 4| 8| 0| 4| 3| 1| 3| 1| 5| 3| 9| 1| 5| 3| 3| 3| 3| 7| 3| 2| 9| 7|      T (*) |

 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|      A     |
    0.01                                   | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      L     |
    MG/M3                                  | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |

 __________________________________________________________________________________________________________________________________ 
 GENITAL SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
      Hyperplasia, Atypical                |                                                                          |      1  3.0|

                                            __________________________________________________________________________|____________|
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |

                                            __________________________________________________________________________|____________|
   Preputial Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Inflammation, Chronic Active         |                         3                 3              4  4            |      4  3.5|

                                            __________________________________________________________________________|____________|
   Prostate                                | +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Hyperplasia                          |                   2        3  1     2     2     3                        |      9  2.1|
      Inflammation, Chronic Active         |                                                                          |      1  4.0|

                                            __________________________________________________________________________|____________|
   Seminal Vesicle                         | +  A  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  47        |
      Mineralization                       |                                                                          |      1  2.0|

                                            __________________________________________________________________________|____________|
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Atrophy                              |    4                                                  3                  |      2  3.5|
      Artery, Inflammation, Chronic Active |                   2                                   3                  |      4  2.5|
      Interstitial Cell, Hyperplasia       |             2                                                            |      3  2.0|

 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  A  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |

                                            __________________________________________________________________________|____________|
   Lymph Node                              |    A        +                    +                    +                  |   8        |
      Renal, Infiltration Cellular, Plasma |                                                                          |            |
          Cell                             |                                                       3                  |      1  3.0|

                                            __________________________________________________________________________|____________|
   Lymph Node, Bronchial                   | +  +  +  +  +  +  +  +  M  +  +  M  M  +  M  +  +  M  +  +  M  +  +  M  +|  37        |

                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  M  +  +  +  +  +  M  +  +  M  +  +  +  +  +  +  +  +  +  M  +  +  +  +|  43        |
      Infiltration Cellular, Plasma Cell   |             2                                                            |      1  2.0|

                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +|  48        |

                                            __________________________________________________________________________|____________|
   Lymph Node, Mediastinal                 | +  +  +  +  +  +  +  M  +  +  M  +  M  +  +  +  M  +  +  +  M  +  +  +  +|  40        |

                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Fibrosis                             |                            2              3        2              2  2  2|     12  2.1|
      Hematopoietic Cell Proliferation     | 3                                                                        |      2  3.0|
      Hyperplasia                          |                                  3                                       |      1  3.0|
      Necrosis                             |                                                                   2      |      1  2.0|

                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  M  +  +  +  +|  45        |

 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  M  M  +  +  +  +  +  +|  42        |
      Galactocele                          |                                                                3         |      2  2.5|

                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |

 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Callus                               |                                                                          |      1  4.0|

 __________________________________________________________________________________________________________________________________ 

  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
NTP Experiment-Test: 05180-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          GALLIUM ARSENIDE                                     Date: 02/17/99  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 08:17:39  
                                                                                                                                    

 __________________________________________________________________________________________________________________________________ 
                                           | 5| 3| 6| 5| 5| 5| 5| 7| 6| 7| 6| 6| 7| 7| 7| 6| 7| 7| 7| 7| 5| 7| 6| 6| 6|            |
                             DAY ON TEST   | 6| 0| 0| 2| 4| 9| 9| 3| 0| 3| 2| 2| 3| 1| 0| 5| 3| 3| 3| 3| 8| 3| 4| 9| 4|            |
                                           | 7| 6| 0| 4| 8| 0| 4| 3| 1| 3| 1| 5| 3| 9| 1| 5| 3| 3| 3| 3| 7| 3| 2| 9| 7|      T (*) |

 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|      A     |
    0.01                                   | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      L     |
    MG/M3                                  | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |

 __________________________________________________________________________________________________________________________________ 
 MUSCULOSKELETAL SYSTEM - cont             |                                                                          |            |
                                           |                                                                          |            |
      Fibrous Osteodystrophy               |    3                                      3  3           3               |      9  2.8|

 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Gliosis                              |                                                                      2   |      1  2.0|

                                            __________________________________________________________________________|____________|
   Peripheral Nerve                        |                                                                          |   1        |

 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Larynx                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia                          |                1                             1  1                    1   |      8  1.0|
      Inflammation, Chronic Active         |                                                                          |      3  1.3|
      Metaplasia, Squamous                 |                                                                      1   |      2  1.0|
      Epiglottis, Hyperplasia              |                                                 1                    1   |      6  1.2|
      Epiglottis, Inflammation, Chronic    |                                                                          |            |
          Active                           |                                                                          |      1  2.0|

                                            __________________________________________________________________________|____________|
   Lung                                    | +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Hemorrhage                           |                                                                   2      |      1  2.0|
      Hyperplasia, Atypical                |                                                                          |      2  2.5|
      Inflammation, Chronic Active         | 1     2  1  2  2  2  2  1  1  1  2        2  2  2  3  2  2  2  1  2  2  1|     43  1.6|
      Mineralization                       |                                           2              3               |      5  3.0|
      Proteinosis                          |       1  1  1     1  1        1  1           1     1     1  1  1     1   |     22  1.0|
      Alveolar Epithelium, Hyperplasia     | 3                          2        1           1  2  3  2     1     1  1|     16  1.6|
      Alveolar Epithelium, Metaplasia      |                                                                          |      2  1.0|
      Artery, Mediastinum, Mineralization  |                                           3                              |      3  3.7|

                                            __________________________________________________________________________|____________|
   Nose                                    | +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Inflammation, Suppurative            |                      2                 2                 2               |      5  2.0|
      Thrombosis                           |       4                                                           2      |      8  2.8|
      Olfactory Epithelium, Atrophy        |                                        2                                 |      2  1.5|
      Olfactory Epithelium, Degeneration,  |                                                                          |            |
           Hyaline                         |       2  2     1  1  1  1  2  1  2  1  2              1  1     1     2  1|     26  1.3|
      Olfactory Epithelium, Metaplasia,    |                                                                          |            |
           Respiratory                     |                                        2                                 |      2  1.5|

                                            __________________________________________________________________________|____________|
   Pleura                                  |                                                                          |   1        |

                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |

 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Eye                                     |    +                                                                     |   2        |
      Cataract                             |                                                                          |      1  4.0|
      Retina, Atrophy                      |                                                                          |      1  4.0|

 __________________________________________________________________________________________________________________________________ 

  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
NTP Experiment-Test: 05180-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          GALLIUM ARSENIDE                                     Date: 02/17/99  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 08:17:39  
                                                                                                                                    

 __________________________________________________________________________________________________________________________________ 
                                           | 5| 3| 6| 5| 5| 5| 5| 7| 6| 7| 6| 6| 7| 7| 7| 6| 7| 7| 7| 7| 5| 7| 6| 6| 6|            |
                             DAY ON TEST   | 6| 0| 0| 2| 4| 9| 9| 3| 0| 3| 2| 2| 3| 1| 0| 5| 3| 3| 3| 3| 8| 3| 4| 9| 4|            |
                                           | 7| 6| 0| 4| 8| 0| 4| 3| 1| 3| 1| 5| 3| 9| 1| 5| 3| 3| 3| 3| 7| 3| 2| 9| 7|      T (*) |

 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|      A     |
    0.01                                   | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      L     |
    MG/M3                                  | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |

 __________________________________________________________________________________________________________________________________ 
 SPECIAL SENSES SYSTEM - cont              |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Zymbal's Gland                          |                                                                         +|   1        |

 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cyst                                 |                                              2                           |      3  2.0|
      Infarct                              |                                                                          |      2  2.0|
      Mineralization                       |                                           2              2               |      4  2.5|
      Nephropathy                          | 1  4  2  2  2  2  4  4  4  3  3  2  3  2  4  4  3  3  4  4  2  3  2  3  3|     49  3.0|
      Renal Tubule, Hyperplasia            |                                                                          |      1  2.0|

                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hemorrhage                           |                                                                2         |      2  3.0|

 __________________________________________________________________________________________________________________________________ 

  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
NTP Experiment-Test: 05180-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          GALLIUM ARSENIDE                                     Date: 02/17/99  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 08:17:39  
                                                                                                                                    

 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 7| 6| 7| 6| 7| 6| 7| 6| 7| 7| 6| 7| 7| 6| 6| 4| 5| 6| 6| 6| 6| 6| 6|             
                             DAY ON TEST   | 2| 3| 3| 0| 3| 7| 3| 0| 3| 9| 0| 3| 2| 3| 2| 7| 6| 4| 6| 1| 7| 5| 9| 4| 7|             
                                           | 7| 3| 3| 4| 3| 4| 3| 1| 3| 8| 4| 3| 7| 3| 0| 4| 0| 3| 6| 7| 8| 4| 8| 2| 1|             

 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    0.1                                    | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
    MG/M3                                  | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             

 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +|             

                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  I  +  +  +  +  I  +  +  +  +  +  +  +  +|             

                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +|             

                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +|             
      Necrosis                             |                               1                                          |             

                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +|             

                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +|             

                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Basophilic Focus                     |    X  X        X                 X     X  X     X           X           X|             
      Clear Cell Focus                     |    X              X              X     X                                 |             
      Degeneration, Cystic                 |          2        1     2              1  2                 1            |             
      Eosinophilic Focus                   |             X                                                            |             
      Fatty Change                         | 2              1           2              2        1     3               |             
      Hepatodiaphragmatic Nodule           |             X        X                                                   |             
      Mineralization                       |                                                                2         |             
      Necrosis                             |                               4                                      2  2|             
      Regeneration                         |                                  2                    4                  |             
      Bile Duct, Hyperplasia               | 2     2  2  3  1     3  2     3  1  3     2  2  2     2  2  2     1      |             
      Bile Duct, Inflammation, Acute       |                               4                                          |             
      Centrilobular, Necrosis              | 1        1           1              1     1           2        4         |             

                                            __________________________________________________________________________|             
   Mesentery                               |                +     +        +                          +        +     +|             
      Hemorrhage                           |                                                                          |             
      Artery, Mineralization               |                                                                         3|             
      Fat, Inflammation                    |                2                                                         |             
      Fat, Necrosis                        |                      2        2                          2        2     2|             

                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              | 4           2  2     1  2              2                    1     2  1   |             
      Basophilic Focus                     |                   X                             X                        |             
      Hyperplasia                          |                   2                                                      |             
      Inflammation, Acute                  |                               3                                          |             
      Metaplasia, Hepatocyte               | 2                                                                        |             
      Artery, Mineralization               |                                                                          |             
      Duct, Hyperplasia                    |                               3                                          |             

                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                                                    2                     |             

                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Squamous                |                                                                      4   |             
      Mineralization                       |                                                                         2|             
      Necrosis                             |       1                    3        3        1           1           3   |             

                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Mineralization                       |    1                          3                                3        3|             
      Necrosis                             |          1           2     2  3     3                 2        3         |             

                                            __________________________________________________________________________|             
   Tongue                                  |                                                       +                  |             

 _____________________________________________________________________________________________________________________|             
NTP Experiment-Test: 05180-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          GALLIUM ARSENIDE                                     Date: 02/17/99  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 08:17:39  
                                                                                                                                    

 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 7| 6| 7| 6| 7| 6| 7| 6| 7| 7| 6| 7| 7| 6| 6| 4| 5| 6| 6| 6| 6| 6| 6|             
                             DAY ON TEST   | 2| 3| 3| 0| 3| 7| 3| 0| 3| 9| 0| 3| 2| 3| 2| 7| 6| 4| 6| 1| 7| 5| 9| 4| 7|             
                                           | 7| 3| 3| 4| 3| 4| 3| 1| 3| 8| 4| 3| 7| 3| 0| 4| 0| 3| 6| 7| 8| 4| 8| 2| 1|             

 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    0.1                                    | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
    MG/M3                                  | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             

 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
                                           |                                                                          |             

 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Blood Vessel                            |                               +                             +           +|             
      Aorta, Mineralization                |                               1                                         4|             

                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cardiomyopathy                       | 1  2  2  1  1  2              3  1     2  2  2  2     2  2     2  1  3  3|             
      Artery, Inflammation, Chronic        |                                                                          |             
      Artery, Mineralization               |                               2           2                             4|             
      Atrium, Thrombosis                   |                                           2           2                  |             

 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +|             
      Degeneration, Cystic                 |                                                                          |             
      Hyperplasia                          |    2  2     2  2        2  2           2     2  2        2     2     2  2|             
      Hypertrophy                          |                                                    1                 2   |             
      Necrosis                             |                      2        2                                          |             
      Vacuolization Cytoplasmic            |                                                                          |             

                                            __________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +|             
      Hyperplasia                          |    4  4     3  2        2  3  3           4              3        2     3|             
      Bilateral, Hyperplasia               |                                              3                           |             

                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                         2                                                |             

                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  M  +  +  +  +  +  +  +  +|             
      Hyperplasia                          | 1     3                    2  2  3        2                       2  2  3|             

                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Pars Distalis, Hyperplasia           |          2  3  1     3  2              2        1                        |             

                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +|             
      C-Cell, Hyperplasia                  |    1  1     2  1  1  1     1     2  3  1           1     2        1  4  2|             
      Follicular Cell, Hyperplasia         |                                     3                                    |             

 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Peritoneum                              |                                                                          |             

 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                                                                          |             

                                            __________________________________________________________________________|             
   Preputial Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                                                          |             
      Inflammation, Chronic Active         |                      4     3  2        4  3                              |             

                                            __________________________________________________________________________|             
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          | 2              1  3     2  4           3        2              3  1      |             
      Inflammation, Chronic Active         |                            3                                         3  2|             

                                            __________________________________________________________________________|             
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic Active         |                                                                          |             

 _____________________________________________________________________________________________________________________|             
NTP Experiment-Test: 05180-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          GALLIUM ARSENIDE                                     Date: 02/17/99  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 08:17:39  
                                                                                                                                    

 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 7| 6| 7| 6| 7| 6| 7| 6| 7| 7| 6| 7| 7| 6| 6| 4| 5| 6| 6| 6| 6| 6| 6|             
                             DAY ON TEST   | 2| 3| 3| 0| 3| 7| 3| 0| 3| 9| 0| 3| 2| 3| 2| 7| 6| 4| 6| 1| 7| 5| 9| 4| 7|             
                                           | 7| 3| 3| 4| 3| 4| 3| 1| 3| 8| 4| 3| 7| 3| 0| 4| 0| 3| 6| 7| 8| 4| 8| 2| 1|             

 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    0.1                                    | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
    MG/M3                                  | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             

 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
      Mineralization                       |                                                                          |             

                                            __________________________________________________________________________|             
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                                  4                                   4   |             
      Artery, Inflammation, Chronic Active |                               3                                   3  3   |             
      Interstitial Cell, Hyperplasia       |                                                    3                     |             

 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Thrombosis                           |                                                                          |             

                                            __________________________________________________________________________|             
   Lymph Node                              |             +                       +        +        +                  |             

                                            __________________________________________________________________________|             
   Lymph Node, Bronchial                   | +  M  +  +  +  +  +  M  M  +  +  +  M  +  +  +  +  +  +  M  +  M  M  M  +|             

                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  M  +  +  M  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +|             
      Infiltration Cellular, Plasma Cell   |                3                                                         |             
      Inflammation, Chronic Active         |                                                    3                     |             

                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

                                            __________________________________________________________________________|             
   Lymph Node, Mediastinal                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +|             
      Infiltration Cellular,               |                                                                          |             
          Polymorphonuclear                |                                                                          |             

                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrosis                             | 2     2     2           2                 2  2        3        2  1      |             
      Hematopoietic Cell Proliferation     |                                           2                 2  2        3|             
      Hyperplasia                          |                                                                          |             
      Inflammation, Acute                  |                                                                          |             
      Necrosis                             |                                     2                                    |             

                                            __________________________________________________________________________|             
   Thymus                                  | +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  M  +  +  M|             

 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  M  M  +  +  +  M  +  +  +  +  +  +  +|             
      Galactocele                          |                                                                          |             

                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperkeratosis                       |                                                                          |             
      Inflammation, Chronic Active         |                4  4                                3                     |             

 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrous Osteodystrophy               |       3                       2  1                             3     1  4|             

 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Larynx                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +|             
      Hyperplasia                          |                                                                1        1|             
      Inflammation, Chronic Active         |                                                                1        1|             

 _____________________________________________________________________________________________________________________|             
NTP Experiment-Test: 05180-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          GALLIUM ARSENIDE                                     Date: 02/17/99  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 08:17:39  
                                                                                                                                    

 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 7| 6| 7| 6| 7| 6| 7| 6| 7| 7| 6| 7| 7| 6| 6| 4| 5| 6| 6| 6| 6| 6| 6|             
                             DAY ON TEST   | 2| 3| 3| 0| 3| 7| 3| 0| 3| 9| 0| 3| 2| 3| 2| 7| 6| 4| 6| 1| 7| 5| 9| 4| 7|             
                                           | 7| 3| 3| 4| 3| 4| 3| 1| 3| 8| 4| 3| 7| 3| 0| 4| 0| 3| 6| 7| 8| 4| 8| 2| 1|             

 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    0.1                                    | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
    MG/M3                                  | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             

 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
      Metaplasia, Squamous                 |                                                                         2|             
      Mineralization                       |                                                                2        2|             
      Epiglottis, Hyperplasia              |                                                                1        2|             
      Epiglottis, Inflammation, Chronic    |                                                                          |             
          Active                           |                                                                1        1|             

                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Atypical                |             2           3                       1                       2|             
      Inflammation, Chronic Active         | 3  3  3  3  3  3  3  3  3  3  3  3  4  3  2  3  3  3  3  3  3  3  3  3  4|             
      Metaplasia, Squamous                 |                         2                                                |             
      Mineralization                       |                                                                         4|             
      Proteinosis                          | 1  3  2  2  2  3  3  3  2  3  2  2  2  2  2  2  3  4  3  2  3  2  3  2  2|             
      Alveolar Epithelium, Hyperplasia     | 3  1  2  3  2  2  3     3  3  2           2  1  1     2     1            |             
      Alveolar Epithelium, Metaplasia      | 2  2        2  2  3     3  2  2  3  3  3  2     2  1     2     2  2  1  2|             
      Artery, Mediastinum, Mineralization  |                                                                         4|             

                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Suppurative            |                         2                    3           1     2     3   |             
      Polyp Inflammatory                   |                                                                          |             
      Thrombosis                           |          4                          3                 4                  |             
      Olfactory Epithelium, Atrophy        |                                                                      1   |             
      Olfactory Epithelium, Degeneration,  |                                                                          |             
           Hyaline                         | 1        2  2  1  1  2  1  1  1  1  2  2     1  2        1  1     1  1  1|             
      Olfactory Epithelium, Metaplasia,    |                                                                          |             
           Respiratory                     |                                                                      1   |             

                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +|             
      Mineralization                       |                                                                2        2|             

 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Ear                                     |                                                                          |             

                                            __________________________________________________________________________|             
   Eye                                     |                                                                          |             
      Degeneration                         |                                                                          |             

 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                                                          |             
      Infarct                              |                                                                          |             
      Mineralization                       |                               2                                3        3|             
      Nephropathy                          | 3  4  4  2  3  2  4  3  4  4  4  4  3  3  4  4  3  2  2  3  3  4  4  4  4|             
      Renal Tubule, Hyperplasia            |    4  3                          1                                       |             

                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

 _____________________________________________________________________________________________________________________|             
NTP Experiment-Test: 05180-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          GALLIUM ARSENIDE                                     Date: 02/17/99  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 08:17:39  
                                                                                                                                    

 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 5| 5| 7| 7| 7| 6| 6| 7| 5| 5| 7| 6| 7| 7| 7| 6| 6| 7| 4| 6| 5| 3| 6|            |
                             DAY ON TEST   | 3| 0| 6| 9| 3| 3| 3| 1| 6| 3| 1| 6| 0| 6| 3| 3| 2| 8| 4| 3| 5| 2| 9| 9| 0|            |
                                           | 3| 2| 0| 0| 3| 3| 3| 5| 2| 3| 3| 2| 2| 0| 3| 3| 2| 0| 2| 3| 0| 1| 0| 4| 1|      T (*) |

 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|      A     |
    0.1                                    | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      L     |
    MG/M3                                  | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |

 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |

                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |

                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  47        |

                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |

                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Necrosis                             |                                                    1                     |      2  1.0|

                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |

                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |

                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Basophilic Focus                     |             X  X  X  X     X     X        X        X  X  X     X        X|     21     |
      Clear Cell Focus                     |                X                                         X               |      6     |
      Degeneration, Cystic                 | 4                                   4  2  3                              |     10  2.2|
      Eosinophilic Focus                   |                            X        X     X     X                        |      5     |
      Fatty Change                         |                                  1     2                                 |      8  1.8|
      Hepatodiaphragmatic Nodule           |                                                    X                     |      3     |
      Mineralization                       |                                                                          |      1  2.0|
      Necrosis                             |          3                                                               |      4  2.8|
      Regeneration                         |    4                       3        2                                    |      5  3.0|
      Bile Duct, Hyperplasia               | 4  2     2  2        1  4  3  2     2     2  3  3           2     2     2|     32  2.2|
      Bile Duct, Inflammation, Acute       |          4                                                               |      2  4.0|
      Centrilobular, Necrosis              |    2  2              1  3  3  3                 2              3        3|     16  2.1|

                                            __________________________________________________________________________|____________|
   Mesentery                               |    +  +                                +     +        +  +     +        +|  14        |
      Hemorrhage                           |                                                                1         |      1  1.0|
      Artery, Mineralization               |                                        4                                 |      2  3.5|
      Fat, Inflammation                    |                                                                          |      1  2.0|
      Fat, Necrosis                        |    2  2                                      2        2  3              3|     11  2.2|

                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Atrophy                              | 2  1     3  1     2  2  2  2        2  2  2     3     2  3  1     3      |     25  2.0|
      Basophilic Focus                     |                                                                          |      2     |
      Hyperplasia                          |                                              3                           |      2  2.5|
      Inflammation, Acute                  |                                                                          |      1  3.0|
      Metaplasia, Hepatocyte               |                                                                          |      1  2.0|
      Artery, Mineralization               |                                        2                                 |      1  2.0|
      Duct, Hyperplasia                    |                                                                          |      1  3.0|

                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Atrophy                              |                                                                          |      1  2.0|

                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia, Squamous                |                                                                          |      1  4.0|
      Mineralization                       |                                        3                                 |      2  2.5|

 __________________________________________________________________________________________________________________________________ 

  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
NTP Experiment-Test: 05180-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          GALLIUM ARSENIDE                                     Date: 02/17/99  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 08:17:39  
                                                                                                                                    

 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 5| 5| 7| 7| 7| 6| 6| 7| 5| 5| 7| 6| 7| 7| 7| 6| 6| 7| 4| 6| 5| 3| 6|            |
                             DAY ON TEST   | 3| 0| 6| 9| 3| 3| 3| 1| 6| 3| 1| 6| 0| 6| 3| 3| 2| 8| 4| 3| 5| 2| 9| 9| 0|            |
                                           | 3| 2| 0| 0| 3| 3| 3| 5| 2| 3| 3| 2| 2| 0| 3| 3| 2| 0| 2| 3| 0| 1| 0| 4| 1|      T (*) |

 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|      A     |
    0.1                                    | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      L     |
    MG/M3                                  | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |

 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
                                           |                                                                          |            |
      Necrosis                             |       3                          4                 4                     |      9  2.6|

                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Mineralization                       |    2     1        4                    4                                 |      8  2.6|
      Necrosis                             |       3                       3                    2  2     1           3|     13  2.3|

                                            __________________________________________________________________________|____________|
   Tongue                                  |                                     +                                    |   2        |

 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Blood Vessel                            |                   +                    +                          +      |   6        |
      Aorta, Mineralization                |                   3                    4                                 |      4  3.0|

                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cardiomyopathy                       | 3  2  2  2  3  2  3  2  3  2     1  2  3  2  2  2  3  2  1  1  2  2     2|     41  2.0|
      Artery, Inflammation, Chronic        |                                                                      3   |      1  3.0|
      Artery, Mineralization               |                   3                    4                                 |      5  3.0|
      Atrium, Thrombosis                   |                                                 4                        |      3  2.7|

 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Degeneration, Cystic                 |                                                 1                        |      1  1.0|
      Hyperplasia                          |          2     2  2  2                          2  2     2     2  2  2   |     23  2.0|
      Hypertrophy                          |                                              2                           |      3  1.7|
      Necrosis                             | 2                             2                                          |      4  2.0|
      Vacuolization Cytoplasmic            |             2                    2                                       |      2  2.0|

                                            __________________________________________________________________________|____________|
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Hyperplasia                          | 3  3           1  3  1  2     2  2     3  2           2                  |     22  2.6|
      Bilateral, Hyperplasia               |                                                                          |      1  3.0|

                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia                          |                                                                   3      |      2  2.5|

                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  47        |
      Hyperplasia                          |    1              4  2           2  2  4           2                 4   |     17  2.4|

                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Pars Distalis, Hyperplasia           |          1              2  2        2  1                 4     2     2   |     15  2.0|

                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      C-Cell, Hyperplasia                  | 1  2     1  1  1     1     1  2     3  1  1  1  2  2  1  2     1        1|     33  1.5|
      Follicular Cell, Hyperplasia         |                                                                          |      1  3.0|

 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Peritoneum                              |                                                    +                     |   1        |

 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |

 __________________________________________________________________________________________________________________________________ 

  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
NTP Experiment-Test: 05180-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          GALLIUM ARSENIDE                                     Date: 02/17/99  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 08:17:39  
                                                                                                                                    

 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 5| 5| 7| 7| 7| 6| 6| 7| 5| 5| 7| 6| 7| 7| 7| 6| 6| 7| 4| 6| 5| 3| 6|            |
                             DAY ON TEST   | 3| 0| 6| 9| 3| 3| 3| 1| 6| 3| 1| 6| 0| 6| 3| 3| 2| 8| 4| 3| 5| 2| 9| 9| 0|            |
                                           | 3| 2| 0| 0| 3| 3| 3| 5| 2| 3| 3| 2| 2| 0| 3| 3| 2| 0| 2| 3| 0| 1| 0| 4| 1|      T (*) |

 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|      A     |
    0.1                                    | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      L     |
    MG/M3                                  | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |

 __________________________________________________________________________________________________________________________________ 
 GENITAL SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Atrophy                              |                                                                      4   |      1  4.0|

                                            __________________________________________________________________________|____________|
   Preputial Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia                          |                               2                 3                    2   |      3  2.3|
      Inflammation, Chronic Active         |                            4           3                                2|      8  3.1|

                                            __________________________________________________________________________|____________|
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia                          |          1                                      3                        |     11  2.3|
      Inflammation, Chronic Active         |                   2                                2                    4|      6  2.7|

                                            __________________________________________________________________________|____________|
   Seminal Vesicle                         | +  +  A  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Inflammation, Chronic Active         |                                                                         4|      1  4.0|
      Mineralization                       |                   2                                                      |      1  2.0|

                                            __________________________________________________________________________|____________|
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Atrophy                              |    3                                               3                 4   |      5  3.6|
      Artery, Inflammation, Chronic Active |                                  2                 3                     |      5  2.8|
      Interstitial Cell, Hyperplasia       |                               2                                          |      2  2.5|

 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Thrombosis                           |                            2                                             |      1  2.0|

                                            __________________________________________________________________________|____________|
   Lymph Node                              |    +  +              +                    +                             +|   9        |

                                            __________________________________________________________________________|____________|
   Lymph Node, Bronchial                   | +  +  +  +  +  +  M  M  +  +  +  +  M  +  +  +  +  M  +  M  +  +  +  M  M|  35        |

                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +|  46        |
      Infiltration Cellular, Plasma Cell   |                                                                          |      1  3.0|
      Inflammation, Chronic Active         |                                                                          |      1  3.0|

                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |

                                            __________________________________________________________________________|____________|
   Lymph Node, Mediastinal                 | +  M  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  M  +|  46        |
      Infiltration Cellular,               |                                                                          |            |
          Polymorphonuclear                |          3                                                               |      1  3.0|

                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Fibrosis                             | 2           2  1  2        2              2     2                 2      |     17  1.9|
      Hematopoietic Cell Proliferation     |                                        2                       3         |      6  2.3|
      Hyperplasia                          | 4                                                                        |      1  4.0|
      Inflammation, Acute                  |          3                                                               |      1  3.0|
      Necrosis                             |       2                 3     2                                         2|      5  2.2|

                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +|  45        |

 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +  +  +  +  +  +  M  +  +  M  +  +  +  +  +  +  +  +  +  M  M  M  +|  42        |
      Galactocele                          |                3                                                         |      1  3.0|

 __________________________________________________________________________________________________________________________________ 

  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
NTP Experiment-Test: 05180-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          GALLIUM ARSENIDE                                     Date: 02/17/99  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 08:17:39  
                                                                                                                                    

 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 5| 5| 7| 7| 7| 6| 6| 7| 5| 5| 7| 6| 7| 7| 7| 6| 6| 7| 4| 6| 5| 3| 6|            |
                             DAY ON TEST   | 3| 0| 6| 9| 3| 3| 3| 1| 6| 3| 1| 6| 0| 6| 3| 3| 2| 8| 4| 3| 5| 2| 9| 9| 0|            |
                                           | 3| 2| 0| 0| 3| 3| 3| 5| 2| 3| 3| 2| 2| 0| 3| 3| 2| 0| 2| 3| 0| 1| 0| 4| 1|      T (*) |

 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|      A     |
    0.1                                    | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      L     |
    MG/M3                                  | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |

 __________________________________________________________________________________________________________________________________ 
 INTEGUMENTARY SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperkeratosis                       | 4                 4                                                      |      2  4.0|
      Inflammation, Chronic Active         |                                                                          |      3  3.7|

 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Fibrous Osteodystrophy               |                   2                 2  4                             4   |     10  2.6|

 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |

 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Larynx                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Hyperplasia                          |             1                                   1                        |      4  1.0|
      Inflammation, Chronic Active         |             1                                   1                        |      4  1.0|
      Metaplasia, Squamous                 |             1                                                            |      2  1.5|
      Mineralization                       |                                        2                                 |      3  2.0|
      Epiglottis, Hyperplasia              |             1                                   1                        |      4  1.3|
      Epiglottis, Inflammation, Chronic    |                                                                          |            |
          Active                           |                                                                          |      2  1.0|

                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia, Atypical                |          2                                                               |      5  2.0|
      Inflammation, Chronic Active         | 3  3  3  3  3  3  3  2  3  3  3  3  3  2  4  3  3  3  3  3  2  3  2  2  2|     50  2.9|
      Metaplasia, Squamous                 |                                                                          |      1  2.0|
      Mineralization                       |                   4                    4                                 |      3  4.0|
      Proteinosis                          | 1  3  2  3  2  3  2  2  2  2  3  3  2  2  2  2  3  2  3  3  3  3  2  2  2|     50  2.4|
      Alveolar Epithelium, Hyperplasia     |          2     1                                   2           2  2     2|     21  2.0|
      Alveolar Epithelium, Metaplasia      | 2  2     3  3  3  3        3     2  2     2  2  3  2     3     2         |     34  2.3|
      Artery, Mediastinum, Mineralization  |                                        2                                 |      2  3.0|

                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Inflammation, Suppurative            |       1           2  2        2  2                                       |     10  2.0|
      Polyp Inflammatory                   |                                                                   3      |      1  3.0|
      Thrombosis                           | 2  2                          2                 2                       4|      8  2.9|
      Olfactory Epithelium, Atrophy        |                                                                          |      1  1.0|
      Olfactory Epithelium, Degeneration,  |                                                                          |            |
           Hyaline                         |    1     2     1  1              2  1  1           1  1     2  2  1  1   |     32  1.3|
      Olfactory Epithelium, Metaplasia,    |                                                                          |            |
           Respiratory                     |                                                                          |      1  1.0|

                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |

 __________________________________________________________________________________________________________________________________ 

  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
NTP Experiment-Test: 05180-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          GALLIUM ARSENIDE                                     Date: 02/17/99  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 08:17:39  
                                                                                                                                    

 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 5| 5| 7| 7| 7| 6| 6| 7| 5| 5| 7| 6| 7| 7| 7| 6| 6| 7| 4| 6| 5| 3| 6|            |
                             DAY ON TEST   | 3| 0| 6| 9| 3| 3| 3| 1| 6| 3| 1| 6| 0| 6| 3| 3| 2| 8| 4| 3| 5| 2| 9| 9| 0|            |
                                           | 3| 2| 0| 0| 3| 3| 3| 5| 2| 3| 3| 2| 2| 0| 3| 3| 2| 0| 2| 3| 0| 1| 0| 4| 1|      T (*) |

 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|      A     |
    0.1                                    | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      L     |
    MG/M3                                  | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |

 __________________________________________________________________________________________________________________________________ 
 RESPIRATORY SYSTEM - cont                 |                                                                          |            |
                                           |                                                                          |            |
      Mineralization                       |                                                                          |      2  2.0|

 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Ear                                     |                                                                         +|   1        |

                                            __________________________________________________________________________|____________|
   Eye                                     |                +                                                         |   1        |
      Degeneration                         |                4                                                         |      1  4.0|

 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cyst                                 |                                        3                                 |      1  3.0|
      Infarct                              |                                                                         2|      1  2.0|
      Mineralization                       |                   2                    4                                 |      5  2.8|
      Nephropathy                          | 3  3  2  3  3  3  4  4  3  3  2  4  4  4  4  4  3  4  2  4  2  3  3  4  3|     50  3.3|
      Renal Tubule, Hyperplasia            |                                     2                                    |      4  2.5|

                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |

 __________________________________________________________________________________________________________________________________ 

  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
NTP Experiment-Test: 05180-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          GALLIUM ARSENIDE                                     Date: 02/17/99  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 08:17:39  
                                                                                                                                    

 _____________________________________________________________________________________________________________________              
                                           | 6| 6| 7| 7| 7| 5| 7| 6| 5| 6| 5| 6| 4| 7| 6| 6| 5| 6| 5| 7| 6| 5| 7| 7| 7|             
                             DAY ON TEST   | 6| 7| 3| 3| 3| 2| 3| 1| 1| 4| 2| 3| 2| 0| 0| 0| 4| 2| 3| 3| 6| 5| 3| 1| 3|             
                                           | 8| 8| 3| 3| 3| 0| 3| 8| 9| 5| 3| 3| 2| 2| 5| 4| 0| 1| 9| 3| 8| 7| 3| 3| 3|             

 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|             
    1.0                                    | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
    MG/M3                                  | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             

 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Anus, Hyperplasia                    |                                                                          |             

                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Necrosis                             |                4                                                         |             

                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Acute                  |                                                                2         |             

                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Mineralization                       |                                           1                              |             

                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                      3        3                                          |             
      Basophilic Focus                     |       X  X  X     X                    X                 X           X  X|             
      Clear Cell Focus                     |             X                                   X        X        X      |             
      Degeneration, Cystic                 |    2     2        3  2        2           1  3                       1  1|             
      Eosinophilic Focus                   |                                                             X            |             
      Fatty Change                         |                      3     1                          1        1         |             
      Hepatodiaphragmatic Nodule           |                                                                         X|             
      Necrosis                             |                                                                          |             
      Bile Duct, Hyperplasia               | 2  3  2  1  2  2  2           2        2     2           2  3            |             
      Centrilobular, Necrosis              | 2  2                                         1              2            |             

                                            __________________________________________________________________________|             
   Mesentery                               |    +              +           +        +  +                              |             
      Artery, Mineralization               |                                           3                              |             
      Fat, Necrosis                        |    2              2           2           3                              |             

                                            __________________________________________________________________________|             
   Oral Mucosa                             |                                                                          |             

                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              | 2  2  2        2  2     1        2     2  3  3  2     3                  |             
      Basophilic Focus                     |                         X                                                |             
      Hyperplasia                          |          2                                                               |             
      Artery, Inflammation                 |          3                                                               |             
      Artery, Mineralization               |                                                                          |             

                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Acute                  |                      2                                                   |             
      Mineralization                       |                                           2                          1   |             
      Necrosis                             |                3     2                                4        4        4|             

                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Mineralization                       |          2        3        3           3  4                          4   |             
      Necrosis                             |    3           3     2  1     1              2        3        3        2|             

                                            __________________________________________________________________________|             
   Tongue                                  |                                                                          |             

                                            __________________________________________________________________________|             
   Tooth                                   |                                                    +                     |             
      Developmental Malformation           |                                                    X                     |             
      Inflammation, Chronic Active         |                                                                          |             

 _____________________________________________________________________________________________________________________|             
NTP Experiment-Test: 05180-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          GALLIUM ARSENIDE                                     Date: 02/17/99  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 08:17:39  
                                                                                                                                    

 _____________________________________________________________________________________________________________________              
                                           | 6| 6| 7| 7| 7| 5| 7| 6| 5| 6| 5| 6| 4| 7| 6| 6| 5| 6| 5| 7| 6| 5| 7| 7| 7|             
                             DAY ON TEST   | 6| 7| 3| 3| 3| 2| 3| 1| 1| 4| 2| 3| 2| 0| 0| 0| 4| 2| 3| 3| 6| 5| 3| 1| 3|             
                                           | 8| 8| 3| 3| 3| 0| 3| 8| 9| 5| 3| 3| 2| 2| 5| 4| 0| 1| 9| 3| 8| 7| 3| 3| 3|             

 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|             
    1.0                                    | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
    MG/M3                                  | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             

 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
                                           |                                                                          |             

 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Blood Vessel                            |                   +        +              +                          +   |             
      Aorta, Mineralization                |                   1        4              4                          3   |             

                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cardiomyopathy                       | 2  2  2  3  2  2  3     2  3  2  2  1  2  3     1  1  1  1     1  2  3  2|             
      Necrosis                             |                                                                          |             
      Artery, Mineralization               |                   2        3           3  4                          3   |             
      Atrium, Thrombosis                   |    2                                         2                           |             

 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                                                                          |             
      Hyperplasia                          | 2  2        3     2  2     2        2  2           2  2  2              2|             
      Hypertrophy                          |                                                                          |             
      Necrosis                             |                2                 4                                       |             
      Vacuolization Cytoplasmic            |                                                                          |             

                                            __________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          | 2  4     2  2           4  3     4  2     4  3     3     3  3  2  3  4   |             
      Bilateral, Hyperplasia               |                                        3                                3|             

                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |    3  3                                                                  |             

                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  M  +  +  M  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |          3        3  1  2  3     1        4           2              4   |             

                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                                                   2      |             
      Pars Distalis, Hyperplasia           |                   3           1           1     4  2              1      |             

                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      C-Cell, Hyperplasia                  | 1  1  1     1  1  2  1  1  1        2     1        1        1  2  3      |             

 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             

 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Granuloma Sperm                      |                            1  3              3                           |             

                                            __________________________________________________________________________|             
   Preputial Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                           3                              |             
      Inflammation, Chronic Active         |                            4                                         3   |             

                                            __________________________________________________________________________|             
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |          1  4                                      1              3      |             
      Inflammation, Chronic Active         | 2                                                                        |             

                                            __________________________________________________________________________|             
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

                                            __________________________________________________________________________|             
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

 _____________________________________________________________________________________________________________________|             
NTP Experiment-Test: 05180-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          GALLIUM ARSENIDE                                     Date: 02/17/99  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 08:17:39  
                                                                                                                                    

 _____________________________________________________________________________________________________________________              
                                           | 6| 6| 7| 7| 7| 5| 7| 6| 5| 6| 5| 6| 4| 7| 6| 6| 5| 6| 5| 7| 6| 5| 7| 7| 7|             
                             DAY ON TEST   | 6| 7| 3| 3| 3| 2| 3| 1| 1| 4| 2| 3| 2| 0| 0| 0| 4| 2| 3| 3| 6| 5| 3| 1| 3|             
                                           | 8| 8| 3| 3| 3| 0| 3| 8| 9| 5| 3| 3| 2| 2| 5| 4| 0| 1| 9| 3| 8| 7| 3| 3| 3|             

 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|             
    1.0                                    | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
    MG/M3                                  | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             

 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
      Atrophy                              |                            3                                             |             
      Artery, Inflammation, Chronic Active |                      2                                         2         |             
      Interstitial Cell, Hyperplasia       |                2        2           3           2                        |             

 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

                                            __________________________________________________________________________|             
   Lymph Node                              |       +                                                     +            |             

                                            __________________________________________________________________________|             
   Lymph Node, Bronchial                   | +  +  +  +  +  M  +  +  M  +  +  +  +  +  +  +  +  M  +  M  +  +  +  +  +|             

                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  M  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  M  +  +|             
      Infiltration Cellular, Plasma Cell   |                                                    4                     |             

                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +|             

                                            __________________________________________________________________________|             
   Lymph Node, Mediastinal                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +|             
      Infiltration Cellular, Plasma Cell   |                                                                4         |             
      Pigmentation                         |                2                                                         |             

                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrosis                             | 2        2        2                    2  2                              |             
      Hematopoietic Cell Proliferation     |                            2                                             |             

                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  M  +|             
      Cyst                                 |                                                                          |             

 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  M  +  M  +  +  M  +  +  +  M  +  +  +  M  +  +  +  +|             
      Galactocele                          | 4                                                              2         |             

                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic Active         |       3                                            3                     |             

 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrous Osteodystrophy               |          3        3     1  3           3  3                          2   |             
      Hyperostosis                         |                                                                          |             
      Inflammation, Chronic Active         |                                                    3                     |             

 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |                3                                                         |             
      Mineralization                       |                                                                          |             

 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Larynx                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          | 2                 2           1        1  1                       1  1   |             
      Inflammation, Chronic Active         | 1                 2        1  1        1  1                       2  1   |             
      Metaplasia, Squamous                 | 1                 2        2  1        1  1                       2      |             
      Mineralization                       |                                                                          |             
      Epiglottis, Hyperplasia              |                   2        2              1                              |             

 _____________________________________________________________________________________________________________________|             
NTP Experiment-Test: 05180-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          GALLIUM ARSENIDE                                     Date: 02/17/99  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 08:17:39  
                                                                                                                                    

 _____________________________________________________________________________________________________________________              
                                           | 6| 6| 7| 7| 7| 5| 7| 6| 5| 6| 5| 6| 4| 7| 6| 6| 5| 6| 5| 7| 6| 5| 7| 7| 7|             
                             DAY ON TEST   | 6| 7| 3| 3| 3| 2| 3| 1| 1| 4| 2| 3| 2| 0| 0| 0| 4| 2| 3| 3| 6| 5| 3| 1| 3|             
                                           | 8| 8| 3| 3| 3| 0| 3| 8| 9| 5| 3| 3| 2| 2| 5| 4| 0| 1| 9| 3| 8| 7| 3| 3| 3|             

 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|             
    1.0                                    | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
    MG/M3                                  | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             

 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
      Epiglottis, Inflammation, Chronic    |                                                                          |             
          Active                           |                   3                       1                       2      |             
      Epiglottis, Metaplasia, Squamous     |                                           1                       1      |             
      Epiglottis, Mineralization           |                                                                          |             

                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst, Squamous                       |                                                                          |             
      Hyperplasia, Atypical                | 2        3  3  2     2  2                       2        3        2     3|             
      Inflammation, Chronic Active         | 4  4  4  4  4  4  4  4  4  4  4  4  3  4  3  3  4  4  4  4  3  3  4  3  4|             
      Metaplasia, Squamous                 |          2                                                              4|             
      Mineralization                       |          2        2        4           4  4                          3   |             
      Proteinosis                          | 3  4  4  3  4  4  3  4  3     4  4  3  2  2  3  4  4  3  4  4  3  4  2  4|             
      Thrombosis                           |                2                                                         |             
      Alveolar Epithelium, Hyperplasia     | 2     2     2                 2        3              2  1  2     2     2|             
      Alveolar Epithelium, Metaplasia      | 1  2  2  2  2     2  1  2  2  2  3     3     2  1  2  2  3  3  1  3  2  2|             
      Artery, Mediastinum, Mineralization  |                   2        3              4                          4   |             

                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Suppurative            |          1     3           2              2        1                 2   |             
      Thrombosis                           |    4           4                             3                           |             
      Olfactory Epithelium, Atrophy        |                                        2  1                              |             
      Olfactory Epithelium, Degeneration,  |                                                                          |             
           Hyaline                         |                1        2        1  1  1     1  1  2        1        1  1|             
      Olfactory Epithelium, Metaplasia,    |                                                                          |             
           Respiratory                     |                                        1  1                              |             
      Respiratory Epithelium, Degeneration,|                                                                          |             
           Hyaline                         |                                                                          |             
      Respiratory Epithelium, Metaplasia,  |                                                                          |             
           Squamous                        |                                                                          |             
      Turbinate, Necrosis                  |                2                                                         |             

                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Mineralization                       |                            3                                         1   |             

 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Eye                                     |                                                                          |             
      Cataract                             |                                                                          |             
      Retina, Atrophy                      |                                                                          |             

 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                                                      2   |             
      Infarct                              |                                                                          |             
      Mineralization                       |                            4              4                          3   |             
      Nephropathy                          | 4  4  2  4  3  2  4  4  4  4  2  3  3  4  4  2  2  3  4  3  2  4  3  4  4|             
      Renal Tubule, Hyperplasia            |                   2  3                                                   |             

                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

 _____________________________________________________________________________________________________________________|             
NTP Experiment-Test: 05180-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          GALLIUM ARSENIDE                                     Date: 02/17/99  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 08:17:39  
                                                                                                                                    

 __________________________________________________________________________________________________________________________________ 
                                           | 6| 7| 5| 7| 7| 7| 7| 7| 5| 7| 4| 5| 7| 6| 6| 7| 6| 5| 6| 7| 6| 6| 7| 6| 3|            |
                             DAY ON TEST   | 1| 0| 9| 1| 3| 3| 0| 3| 3| 3| 2| 9| 0| 2| 0| 3| 0| 4| 3| 3| 1| 4| 3| 4| 1|            |
                                           | 5| 2| 4| 5| 3| 3| 2| 3| 3| 3| 2| 0| 0| 1| 2| 2| 1| 7| 1| 3| 4| 2| 3| 5| 0|      T (*) |

 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|      A     |
    1.0                                    | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      L     |
    MG/M3                                  | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |

 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |

                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |

                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  I  +  +  +  +|  49        |
      Anus, Hyperplasia                    |          4                                                               |      1  4.0|

                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +|  49        |
      Necrosis                             |                                                                          |      1  4.0|

                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inflammation, Acute                  |                                                                          |      1  2.0|

                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |

                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Mineralization                       |                                                                          |      1  1.0|

                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Angiectasis                          |             1        2           3                                       |      5  2.4|
      Basophilic Focus                     |          X        X  X     X              X           X           X      |     15     |
      Clear Cell Focus                     |             X        X     X                             X        X      |      9     |
      Degeneration, Cystic                 |                                     2                                    |     10  1.9|
      Eosinophilic Focus                   |                            X           X           X                     |      4     |
      Fatty Change                         | 2        2        2                                                      |      7  1.7|
      Hepatodiaphragmatic Nodule           |                            X                                             |      2     |
      Necrosis                             |                                        1                                 |      1  1.0|
      Bile Duct, Hyperplasia               | 2  4  3  1  1     2  2  2        2  3  1     2  1  3  1     2  2     3   |     30  2.1|
      Centrilobular, Necrosis              | 1                 1     2           2        1     1  1     1        1   |     13  1.4|

                                            __________________________________________________________________________|____________|
   Mesentery                               |          +                                                  +            |   7        |
      Artery, Mineralization               |          4                                                               |      2  3.5|
      Fat, Necrosis                        |                                                             2            |      5  2.2|

                                            __________________________________________________________________________|____________|
   Oral Mucosa                             |                            +                                             |   1        |

                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Atrophy                              | 1  2     3  1     2     2  2     2  1  3        1  2  2     1        1   |     27  1.9|
      Basophilic Focus                     |                            X                             X               |      3     |
      Hyperplasia                          |                                                                          |      1  2.0|
      Artery, Inflammation                 |                                                                          |      1  3.0|
      Artery, Mineralization               |          2                                                               |      1  2.0|

                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |

                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inflammation, Acute                  |                                                                          |      1  2.0|
      Mineralization                       |                                                                          |      2  1.5|
      Necrosis                             |    1  2                             3     1     2     3                  |     11  2.6|

                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Mineralization                       |          4                             3                                 |      8  3.3|

 __________________________________________________________________________________________________________________________________ 

  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
NTP Experiment-Test: 05180-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          GALLIUM ARSENIDE                                     Date: 02/17/99  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 08:17:39  
                                                                                                                                    

 __________________________________________________________________________________________________________________________________ 
                                           | 6| 7| 5| 7| 7| 7| 7| 7| 5| 7| 4| 5| 7| 6| 6| 7| 6| 5| 6| 7| 6| 6| 7| 6| 3|            |
                             DAY ON TEST   | 1| 0| 9| 1| 3| 3| 0| 3| 3| 3| 2| 9| 0| 2| 0| 3| 0| 4| 3| 3| 1| 4| 3| 4| 1|            |
                                           | 5| 2| 4| 5| 3| 3| 2| 3| 3| 3| 2| 0| 0| 1| 2| 2| 1| 7| 1| 3| 4| 2| 3| 5| 0|      T (*) |

 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|      A     |
    1.0                                    | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      L     |
    MG/M3                                  | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |

 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
                                           |                                                                          |            |
      Necrosis                             |       3                 2           3              2                     |     13  2.3|

                                            __________________________________________________________________________|____________|
   Tongue                                  |                   +                                                      |   1        |

                                            __________________________________________________________________________|____________|
   Tooth                                   |                                                                +        +|   3        |
      Developmental Malformation           |                                                                X        X|      3     |
      Inflammation, Chronic Active         |                                                                         3|      1  3.0|

 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Blood Vessel                            |          +                             +                                 |   6        |
      Aorta, Mineralization                |          4                             1                                 |      6  2.8|

                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cardiomyopathy                       | 3     1  4  2  2  2  2     2  2     3  3  2  2        2  3  2     2  1   |     40  2.1|
      Necrosis                             |                                                    3                     |      1  3.0|
      Artery, Mineralization               |          4        1                                                      |      7  2.9|
      Atrium, Thrombosis                   |                                                                          |      2  2.0|

 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Atrophy                              |                                     2                                    |      1  2.0|
      Hyperplasia                          |          2     2  2        2     2     2  2     2  2           2     2   |     23  2.0|
      Hypertrophy                          |                      2                                      2            |      2  2.0|
      Necrosis                             |                                        1                                 |      3  2.3|
      Vacuolization Cytoplasmic            |                                                          2               |      1  2.0|

                                            __________________________________________________________________________|____________|
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia                          |    3  1     3        4                 3           2        3  4  3  4   |     26  3.0|
      Bilateral, Hyperplasia               | 3        4              4        3                       2               |      7  3.1|

                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia                          |          3                                                     2         |      4  2.8|

                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Hyperplasia                          |          4     3     3                 4     1           2  2            |     16  2.6|

                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Angiectasis                          |                                                                          |      1  2.0|
      Pars Distalis, Hyperplasia           |    2  2     2                    3  2  2                                 |     12  2.1|

                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      C-Cell, Hyperplasia                  |    1  1     1  1  1     1  3              2     2        1  1  1     2  1|     29  1.3|

 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |

 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |

 __________________________________________________________________________________________________________________________________ 

  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
NTP Experiment-Test: 05180-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          GALLIUM ARSENIDE                                     Date: 02/17/99  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 08:17:39  
                                                                                                                                    

 __________________________________________________________________________________________________________________________________ 
                                           | 6| 7| 5| 7| 7| 7| 7| 7| 5| 7| 4| 5| 7| 6| 6| 7| 6| 5| 6| 7| 6| 6| 7| 6| 3|            |
                             DAY ON TEST   | 1| 0| 9| 1| 3| 3| 0| 3| 3| 3| 2| 9| 0| 2| 0| 3| 0| 4| 3| 3| 1| 4| 3| 4| 1|            |
                                           | 5| 2| 4| 5| 3| 3| 2| 3| 3| 3| 2| 0| 0| 1| 2| 2| 1| 7| 1| 3| 4| 2| 3| 5| 0|      T (*) |

 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|      A     |
    1.0                                    | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      L     |
    MG/M3                                  | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |

 __________________________________________________________________________________________________________________________________ 
 GENITAL SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Granuloma Sperm                      |                                                                          |      3  2.3|

                                            __________________________________________________________________________|____________|
   Preputial Gland                         | +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Hyperplasia                          |             2                          2                          2      |      4  2.3|
      Inflammation, Chronic Active         |                                                                   3      |      3  3.3|

                                            __________________________________________________________________________|____________|
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia                          |             2                                            1        2      |      7  2.0|
      Inflammation, Chronic Active         |                            2                                             |      2  2.0|

                                            __________________________________________________________________________|____________|
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |

                                            __________________________________________________________________________|____________|
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Atrophy                              |                   3                    3                    3  4         |      5  3.2|
      Artery, Inflammation, Chronic Active |          2                             3                                 |      4  2.3|
      Interstitial Cell, Hyperplasia       |       1                                         1                        |      6  1.8|

 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |

                                            __________________________________________________________________________|____________|
   Lymph Node                              |    +                                               +                 +   |   5        |

                                            __________________________________________________________________________|____________|
   Lymph Node, Bronchial                   | +  +  +  M  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  M  +  +  M|  42        |

                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +  M  +  M  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +|  44        |
      Infiltration Cellular, Plasma Cell   |                                                                4        4|      3  4.0|

                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |

                                            __________________________________________________________________________|____________|
   Lymph Node, Mediastinal                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  M  +  +|  47        |
      Infiltration Cellular, Plasma Cell   |                                                                          |      1  4.0|
      Pigmentation                         |                                                                          |      1  2.0|

                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Fibrosis                             |    2        3  2     2                                   2  2     2      |     12  2.1|
      Hematopoietic Cell Proliferation     |                                                                          |      1  2.0|

                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  +  M  +  +  I  +  +  M  +  +  M  M  +  +  +|  42        |
      Cyst                                 |                                     3                                    |      1  3.0|

 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  M  M  +  +  +  M  +|  40        |
      Galactocele                          |                                                                3         |      3  3.0|

                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inflammation, Chronic Active         |                                                                          |      2  3.0|

 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Fibrous Osteodystrophy               |          4     1     1                 3                                 |     11  2.5|

 __________________________________________________________________________________________________________________________________ 

  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
NTP Experiment-Test: 05180-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          GALLIUM ARSENIDE                                     Date: 02/17/99  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 08:17:39  
                                                                                                                                    

 __________________________________________________________________________________________________________________________________ 
                                           | 6| 7| 5| 7| 7| 7| 7| 7| 5| 7| 4| 5| 7| 6| 6| 7| 6| 5| 6| 7| 6| 6| 7| 6| 3|            |
                             DAY ON TEST   | 1| 0| 9| 1| 3| 3| 0| 3| 3| 3| 2| 9| 0| 2| 0| 3| 0| 4| 3| 3| 1| 4| 3| 4| 1|            |
                                           | 5| 2| 4| 5| 3| 3| 2| 3| 3| 3| 2| 0| 0| 1| 2| 2| 1| 7| 1| 3| 4| 2| 3| 5| 0|      T (*) |

 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|      A     |
    1.0                                    | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      L     |
    MG/M3                                  | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |

 __________________________________________________________________________________________________________________________________ 
 MUSCULOSKELETAL SYSTEM - cont             |                                                                          |            |
                                           |                                                                          |            |
      Hyperostosis                         |                                     2                                    |      1  2.0|
      Inflammation, Chronic Active         |                                                                          |      1  3.0|

 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hemorrhage                           |                                                                          |      1  3.0|
      Mineralization                       |                   2                                                      |      1  2.0|

 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Larynx                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia                          |          2                       1     1  1                              |     11  1.3|
      Inflammation, Chronic Active         |          2                       1     1  1                              |     12  1.3|
      Metaplasia, Squamous                 |          2                       1        1                              |     10  1.4|
      Mineralization                       |          2                                                               |      1  2.0|
      Epiglottis, Hyperplasia              |          2                             1                                 |      5  1.6|
      Epiglottis, Inflammation, Chronic    |                                                                          |            |
          Active                           |                                        1                                 |      4  1.8|
      Epiglottis, Metaplasia, Squamous     |                                           1                              |      3  1.0|
      Epiglottis, Mineralization           |          1                                                               |      1  1.0|

                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cyst, Squamous                       |                                                          4               |      1  4.0|
      Hyperplasia, Atypical                | 1        2  4  4                    4              2     1        3      |     18  2.5|
      Inflammation, Chronic Active         | 4  4  3  4  4  4  4  4  3  4  4  4  4  3  3  4  4  4  4  4  4  4  4  4  4|     50  3.8|
      Metaplasia, Squamous                 |                                                                          |      2  3.0|
      Mineralization                       |          4                                                               |      7  3.3|
      Proteinosis                          | 3  4  4  3  4  3  4  3  4  4  4  4  4  2  4  2  4  4  3  4  3  3  3  2  2|     49  3.4|
      Thrombosis                           |                                  4                                       |      2  3.0|
      Alveolar Epithelium, Hyperplasia     |             2        2     2  2     2  2  4  3        1        1  4      |     21  2.1|
      Alveolar Epithelium, Metaplasia      | 2        2  3  3  3  2     3  1  3  3  3     3     1  2  3  2  2  3  3   |     41  2.2|
      Artery, Mediastinum, Mineralization  |          3                                                               |      5  3.2|

                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inflammation, Suppurative            |                                              2              2            |      8  1.9|
      Thrombosis                           |                         3        3  2                 4                  |      7  3.3|
      Olfactory Epithelium, Atrophy        |                                                                          |      2  1.5|
      Olfactory Epithelium, Degeneration,  |                                                                          |            |
           Hyaline                         | 1  2  2           1     2     2  2           2  1  1  1  1  1     1      |     25  1.3|
      Olfactory Epithelium, Metaplasia,    |                                                                          |            |
           Respiratory                     |                                                                          |      2  1.0|
      Respiratory Epithelium, Degeneration,|                                                                          |            |

 __________________________________________________________________________________________________________________________________ 

  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
NTP Experiment-Test: 05180-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          GALLIUM ARSENIDE                                     Date: 02/17/99  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 08:17:39  
                                                                                                                                    

 __________________________________________________________________________________________________________________________________ 
                                           | 6| 7| 5| 7| 7| 7| 7| 7| 5| 7| 4| 5| 7| 6| 6| 7| 6| 5| 6| 7| 6| 6| 7| 6| 3|            |
                             DAY ON TEST   | 1| 0| 9| 1| 3| 3| 0| 3| 3| 3| 2| 9| 0| 2| 0| 3| 0| 4| 3| 3| 1| 4| 3| 4| 1|            |
                                           | 5| 2| 4| 5| 3| 3| 2| 3| 3| 3| 2| 0| 0| 1| 2| 2| 1| 7| 1| 3| 4| 2| 3| 5| 0|      T (*) |

 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|      A     |
    1.0                                    | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      L     |
    MG/M3                                  | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |

 __________________________________________________________________________________________________________________________________ 
 RESPIRATORY SYSTEM - cont                 |                                                                          |            |
                                           |                                                                          |            |
           Hyaline                         |                   2                                                      |      1  2.0|
      Respiratory Epithelium, Metaplasia,  |                                                                          |            |
           Squamous                        |                                              2                           |      1  2.0|
      Turbinate, Necrosis                  |                                                                          |      1  2.0|

                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Mineralization                       |          3                                                               |      3  2.3|

 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Eye                                     |             +                                                            |   1        |
      Cataract                             |             4                                                            |      1  4.0|
      Retina, Atrophy                      |             4                                                            |      1  4.0|

 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cyst                                 |                                                                          |      1  2.0|
      Infarct                              |                                     3              2                     |      2  2.5|
      Mineralization                       |          4                                                               |      4  3.8|
      Nephropathy                          | 3  3  2  4  3  4  3  4  3  3  1  2  3  4  3  3  3  2  3  4  2  3  4  3  1|     50  3.1|
      Renal Tubule, Hyperplasia            |                                                                          |      2  2.5|

                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |

 __________________________________________________________________________________________________________________________________ 

  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
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                             ----------              END OF REPORT             ----------                                           
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