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TDMS Study 05180-06 Pathology Tables

NTP                                         STATISTICAL ANALYSIS OF SURVIVAL DATA                              REPORT: PEIRPT11     

LAB: Battelle Northwest                                     GALLIUM ARSENIDE                                   DATE: 02/17/99       

EXPERIMENT: 05180 TEST: 06                                                                                     TIME: 08:22:20       

TEST TYPE:  CHRONIC                             CAGES FROM 0000 TO LAST CAGE                                   PAGE:       1        

CONT: NO1-ES-25335                              ROUTE: RESPIRATORY EXPOSURE WHOLE BODY                         NTP C#: 62033B       

PATHOLOGIST: GRUMBEIN, S.                                                                                      CAS: 1303-00-0000    

------------------------------------------------------------------------------------------------------------------------------------

                                                                                                                                    

                                                        2 YEAR CHRONIC RATS                                                         

                                                                                                                                    


               REASONS FOR REMOVAL:    ALL                                                                                          

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

               REMOVAL DATE RANGE:     ALL                                                                                          

                                                                                                                                    

               TREATMENT GROUPS:       INCLUDE ALL                                                                                  
NTP                                         STATISTICAL ANALYSIS OF SURVIVAL DATA                              REPORT: PEIRPT11    

LAB: Battelle Northwest                                     GALLIUM ARSENIDE                                   DATE: 02/17/99      

EXPERIMENT: 05180 TEST: 06                                                                                     TIME: 08:22:20      

TEST TYPE:  CHRONIC                             CAGES FROM 0000 TO LAST CAGE                                                       

CONT: NO1-ES-25335                              ROUTE: RESPIRATORY EXPOSURE WHOLE BODY                         NTP C#: 62033B      

PATHOLOGIST: GRUMBEIN, S.                                                                                      CAS: 1303-00-0000   
                                 GALLIUM ARSENIDE


                       STATISTICAL ANALYSIS OF SURVIVAL DATA

                                     MALE RATS

                       FIRST TERMINAL SACRIFICE AT 733 DAYS

                                                          


                          INDIVIDUAL SURVIVAL TIMES (DAYS)

 ==================================================================================

 |                                DOSE = CONTROL                                  |

 |                             ---------------------                              |

 |                                                                                |

 |  TOTAL 50     UNCENSORED DEATHS 37     CENSORED DEATHS 0    TERMINAL 13        |

 |                                                                                |

 |  UNCENSORED DEATHS                                                             |

 |      338   506   534   534   544   545   566   566   567   567                 |

 |      590   590   599   612   612   617   621   621   636   642                 |

 |      645   647   658   662   662   671   677   681   684   685                 |

 |      685   688   693   713   720   726   729                                   |

 |  CENSORED DEATHS                                                               |

 |      NONE                                                                      |

 |                                                                                |

 |--------------------------------------------------------------------------------|

 |                          DOSE = 0.01    MG/M3                                  |

 |                       ----------------------------                             |

 |                                                                                |

 |  TOTAL 50     UNCENSORED DEATHS 37     CENSORED DEATHS 0    TERMINAL 13        |

 |                                                                                |

 |  UNCENSORED DEATHS                                                             |

 |      204   306   350   393   524   532   534   548   548   566                 |

 |      567   574   586   587   590   590   594   600   601   614                 |

 |      621   621   625   642   647   647   647   655   660   684                 |

 |      691   699   701   708   709   712   719                                   |

 |  CENSORED DEATHS                                                               |

 |      NONE                                                                      |

 |                                                                                |

 |--------------------------------------------------------------------------------|

 |                          DOSE = 0.1     MG/M3                                  |

 |                       ----------------------------                             |

 |                                                                                |

 |  TOTAL 50     UNCENSORED DEATHS 35     CENSORED DEATHS 0    TERMINAL 15        |

 |                                                                                |

 |  UNCENSORED DEATHS                                                             |

 |      394   443   450   513   560   562   566   590   590   601                 |

 |      601   604   615   617   621   627   627   642   642   654                 |

 |      660   660   662   671   674   674   678   680   698   698                 |

 |      702   702   704   720   722                                               |

 |  CENSORED DEATHS                                                               |

 |      NONE                                                                      |

 |                                                                                |

 ==================================================================================
                                 GALLIUM ARSENIDE


                       STATISTICAL ANALYSIS OF SURVIVAL DATA

                                     MALE RATS

                       FIRST TERMINAL SACRIFICE AT 733 DAYS

                                                          


                          INDIVIDUAL SURVIVAL TIMES (DAYS)

 ==================================================================================

 |                          DOSE = 1.0     MG/M3                                  |

 |                       ----------------------------                             |

 |                                                                                |

 |  TOTAL 50     UNCENSORED DEATHS 37     CENSORED DEATHS 0    TERMINAL 13        |

 |                                                                                |

 |  UNCENSORED DEATHS                                                             |

 |      310   422   422   519   520   523   533   539   540   547                 |

 |      557   590   594   601   602   604   605   614   615   618                 |

 |      621   621   631   633   642   645   645   668   668   678                 |

 |      700   702   702   702   713   715   732                                   |

 |  CENSORED DEATHS                                                               |

 |      NONE                                                                      |

 |                                                                                |

 ==================================================================================
                                 GALLIUM ARSENIDE


                       STATISTICAL ANALYSIS OF SURVIVAL DATA

                                     MALE RATS

                       FIRST TERMINAL SACRIFICE AT 733 DAYS


 ==================================================================================

 |               KAPLAN-MEIER SURVIVAL PROBABILITY ESTIMATES (%)                  |

 |                                                                                |

 |--------------------------------------------------------------------------------|

 |    DOSE                               TIME (DAYS)                              |

 |                 90   180   270   365   425   485   545   605   665   733 (A)   |

 |                                                                                |

 |--------------------------------------------------------------------------------|

 |           |                                                                    |

 |CONTROL    |   100.0 100.0 100.0  98.0  98.0  98.0  88.0  74.0  50.0  26.0      |

 |           |                                                                    |

 |           |                                                                    |

 |0.01       |   100.0 100.0  98.0  94.0  92.0  92.0  86.0  62.0  42.0  26.0      |

 |MG/M3      |                                                                    |

 |           |                                                                    |

 |0.1        |   100.0 100.0 100.0 100.0  98.0  94.0  92.0  76.0  54.0  30.0      |

 |MG/M3      |                                                                    |

 |           |                                                                    |

 |1.0        |   100.0 100.0 100.0  98.0  94.0  94.0  82.0  66.0  46.0  26.0      |

 |MG/M3      |                                                                    |

 |           |                                                                    |

 ==================================================================================

 ==================================================================================

 |                           SURVIVAL SUMMARY STATISTICS                          |

 |                                                                                |

 |                                                                                |

 |--------------------------------------------------------------------------------|

 |                                                  DOSE                          |

 |                                                                                |

 |                                CONTROL      0.01         0.1          1.0      |

 |                                             MG/M3        MG/M3        MG/M3    |

 |--------------------------------------------------------------------------------|

 |SURVIVAL AT END OF STUDY|       26.0%        26.0%        30.0%        26.0%    |

 |(KAPLAN-MEIER)          |                                                       |

 |                        |                                                       |

 |SIGNIFICANCE (B)        |       P=0.803      P=0.782      P=0.725N     P=0.838  |

 |(LIFE TABLE)            |                                                       |

 |                        |                                                       |

 |MEAN DAY OF             |       622.5        589.1        623.5        602.5    |

 |NATURAL DEATHS (C)      |       (12.7)       (18.8)       (13.3)       (14.8)   |

 |(STANDARD ERROR)        |                                                       |

 |                        |                                                       |

 |MEAN LIFE SPAN (D)      |       651.2        626.5        656.4        636.4    |

 |(STANDARD ERROR)        |       (11.6)       (16.5)       (11.7)       (13.6)   |

 |                        |                                                       |

 ==================================================================================

                                    


       (A)  FIRST TERMINAL SACRIFICE

       (B)  THE FIRST ENTRY IS THE TREND TEST (TARONE, 1975) RESULT.

            SUBSEQUENT ENTRIES ARE THE RESULTS OF PAIRWISE TESTS

            (COX,1972).  NEGATIVE TRENDS ARE INDICATED BY "N".

       (C)  MEAN OF ALL UNCENSORED DEATHS PRIOR TO TERMINAL SACRIFICE

       (D)  MEAN OF ALL DEATHS (UNCENSORED, CENSORED, TERMINAL SACRIFICE)
                                 GALLIUM ARSENIDE


                       STATISTICAL ANALYSIS OF SURVIVAL DATA

                                    FEMALE RATS

                       FIRST TERMINAL SACRIFICE AT 734 DAYS

                                                          


                          INDIVIDUAL SURVIVAL TIMES (DAYS)

 ==================================================================================

 |                                DOSE = CONTROL                                  |

 |                             ---------------------                              |

 |                                                                                |

 |  TOTAL 50     UNCENSORED DEATHS 31     CENSORED DEATHS 0    TERMINAL 19        |

 |                                                                                |

 |  UNCENSORED DEATHS                                                             |

 |      302   310   497   506   581   582   588   589   590   604                 |

 |      607   621   621   642   649   660   660   660   677   678                 |

 |      679   684   685   688   699   702   703   716   716   730                 |

 |      730                                                                       |

 |  CENSORED DEATHS                                                               |

 |      NONE                                                                      |

 |                                                                                |

 |--------------------------------------------------------------------------------|

 |                          DOSE = 0.01    MG/M3                                  |

 |                       ----------------------------                             |

 |                                                                                |

 |  TOTAL 50     UNCENSORED DEATHS 33     CENSORED DEATHS 0    TERMINAL 17        |

 |                                                                                |

 |  UNCENSORED DEATHS                                                             |

 |      310   422   478   497   509   523   548   559   563   585                 |

 |      590   590   606   613   621   628   631   649   660   685                 |

 |      687   688   688   695   700   702   702   713   714   723                 |

 |      726   726   730                                                           |

 |  CENSORED DEATHS                                                               |

 |      NONE                                                                      |

 |                                                                                |

 |--------------------------------------------------------------------------------|

 |                          DOSE = 0.1     MG/M3                                  |

 |                       ----------------------------                             |

 |                                                                                |

 |  TOTAL 50     UNCENSORED DEATHS 29     CENSORED DEATHS 0    TERMINAL 21        |

 |                                                                                |

 |  UNCENSORED DEATHS                                                             |

 |      198   310   339   354   448   462   534   534   547   603                 |

 |      604   605   609   630   631   639   646   646   647   660                 |

 |      668   674   674   674   678   679   684   701   723                       |

 |  CENSORED DEATHS                                                               |

 |      NONE                                                                      |

 |                                                                                |

 ==================================================================================
                                 GALLIUM ARSENIDE


                       STATISTICAL ANALYSIS OF SURVIVAL DATA

                                    FEMALE RATS

                       FIRST TERMINAL SACRIFICE AT 734 DAYS

                                                          


                          INDIVIDUAL SURVIVAL TIMES (DAYS)

 ==================================================================================

 |                          DOSE = 1.0     MG/M3                                  |

 |                       ----------------------------                             |

 |                                                                                |

 |  TOTAL 50     UNCENSORED DEATHS 39     CENSORED DEATHS 0    TERMINAL 11        |

 |                                                                                |

 |  UNCENSORED DEATHS                                                             |

 |      215   254   310   418   422   476   478   506   519   534                 |

 |      554   556   564   564   590   594   605   631   631   632                 |

 |      632   674   674   677   677   684   685   688   691   691                 |

 |      696   702   703   704   709   712   712   716   730                       |

 |  CENSORED DEATHS                                                               |

 |      NONE                                                                      |

 |                                                                                |

 ==================================================================================
                                 GALLIUM ARSENIDE


                       STATISTICAL ANALYSIS OF SURVIVAL DATA

                                    FEMALE RATS

                       FIRST TERMINAL SACRIFICE AT 734 DAYS


 ==================================================================================

 |               KAPLAN-MEIER SURVIVAL PROBABILITY ESTIMATES (%)                  |

 |                                                                                |

 |--------------------------------------------------------------------------------|

 |    DOSE                               TIME (DAYS)                              |

 |                 90   180   270   365   425   485   545   605   665   734 (A)   |

 |                                                                                |

 |--------------------------------------------------------------------------------|

 |           |                                                                    |

 |CONTROL    |   100.0 100.0 100.0  96.0  96.0  96.0  92.0  80.0  64.0  38.0      |

 |           |                                                                    |

 |           |                                                                    |

 |0.01       |   100.0 100.0 100.0  98.0  96.0  94.0  88.0  76.0  62.0  34.0      |

 |MG/M3      |                                                                    |

 |           |                                                                    |

 |0.1        |   100.0 100.0  98.0  92.0  92.0  88.0  84.0  76.0  60.0  42.0      |

 |MG/M3      |                                                                    |

 |           |                                                                    |

 |1.0        |   100.0 100.0  96.0  94.0  90.0  86.0  80.0  66.0  58.0  22.0      |

 |MG/M3      |                                                                    |

 |           |                                                                    |

 ==================================================================================

 ==================================================================================

 |                           SURVIVAL SUMMARY STATISTICS                          |

 |                                                                                |

 |                                                                                |

 |--------------------------------------------------------------------------------|

 |                                                  DOSE                          |

 |                                                                                |

 |                                CONTROL      0.01         0.1          1.0      |

 |                                             MG/M3        MG/M3        MG/M3    |

 |--------------------------------------------------------------------------------|

 |SURVIVAL AT END OF STUDY|       38.0%        34.0%        42.0%        22.0%    |

 |(KAPLAN-MEIER)          |                                                       |

 |                        |                                                       |

 |SIGNIFICANCE (B)        |       P=0.052      P=0.788      P=1.000      P=0.088  |

 |(LIFE TABLE)            |                                                       |

 |                        |                                                       |

 |MEAN DAY OF             |       624.4        620.0        579.3        595.1    |

 |NATURAL DEATHS (C)      |       (18.6)       (17.3)       (24.7)       (20.9)   |

 |(STANDARD ERROR)        |                                                       |

 |                        |                                                       |

 |MEAN LIFE SPAN (D)      |       666.0        658.8        644.3        625.7    |

 |(STANDARD ERROR)        |       (13.8)       (13.7)       (17.9)       (18.2)   |

 |                        |                                                       |

 ==================================================================================

                                    


       (A)  FIRST TERMINAL SACRIFICE

       (B)  THE FIRST ENTRY IS THE TREND TEST (TARONE, 1975) RESULT.

            SUBSEQUENT ENTRIES ARE THE RESULTS OF PAIRWISE TESTS

            (COX,1972).  NEGATIVE TRENDS ARE INDICATED BY "N".

       (C)  MEAN OF ALL UNCENSORED DEATHS PRIOR TO TERMINAL SACRIFICE

       (D)  MEAN OF ALL DEATHS (UNCENSORED, CENSORED, TERMINAL SACRIFICE)
                                                          GALLIUM ARSENIDE

                                                    KAPLAN-MEIER SURVIVAL CURVES

                                                        CONTROL          = 1

                                                        0.01    MG/M3    = 2

                                                        0.1     MG/M3    = 3

                                                        1.0     MG/M3    = 4



------------------------------------------------------ SPECIES=RATS SEX=MALE -------------------------------------------------------



                                         Plot of SURVIVAL*WEEK.  Symbol is value of DOSE.



      |

  104 +

      |

      | 1                                2                4   1        3

      |                                  2              2 4   1        3   4  3         1

   96 +                                                 2      2              3 3       1    1

      |                                                        2       2   4    3        3 4

      |                                                                2                 3 2 11 3

      |                                                                                    22   33

   88 +                                                                                    4221  1

      |                                                                                      2 2 3    3

      |                                                                                      44

      |                                                                                       42 2    33

P  80 +                                                                                        441    1

E     |                                                                                         422   433

R     |                                                                                           2 2 1133

C     |                                                                                               41 13

E  72 +                                                                                             2 2

N     |                                                                                                44113

T     |

      |                                                                                               2244 3 3

S  64 +                                                                                                   1 1

U     |                                                                                                2 24 11 3

R     |                                                                                                  22  113 3

V     |

I  56 +                                                                                                   224 11

V     |                                                                                                    2 2 1 13

A     |                                                                                                     422   33

L     |                                                                                                      44  11

   48 +                                                                                                           11

      |                                                                                                       22  411

      |                                                                                                        2 2  3 3

      |                                                                                                          2442

   40 +                                                                                                            42233

      |                                                                                                             1124

      |                                                                                                               22

      |                                                                                                              1 213

   32 +                                                                                                                4113

      |                                                                                                                 411 3

      |                                                                                                                 221 1

      |                                                                                                                  2  1

   24 +

      |

      --+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+--

        0         10         20         30         40         50         60         70         80         90         100        110



                                                                   WEEK



NOTE: 29 obs hidden.
                                                          GALLIUM ARSENIDE

                                                    KAPLAN-MEIER SURVIVAL CURVES

                                                        CONTROL          = 1

                                                        0.01    MG/M3    = 2

                                                        0.1     MG/M3    = 3

                                                        1.0     MG/M3    = 4



----------------------------------------------------- SPECIES=RATS SEX=FEMALE ------------------------------------------------------



                                         Plot of SURVIVAL*WEEK.  Symbol is value of DOSE.



      |

      |

  100 + 1                               3 4             1 2

      |                                 3 4      4      1 1                2

      |                                          4        1   3 3         42        2 1 1

      |                                                         3         44  3       2 1          1

   90 +                                                                    4  3  3 4    2  2       11

      |                                                                          3 44      2 3 2

      |                                                                             4   4  4 3 222  1 1

      |                                                                                    4 4 3 2  2 1 1

P  80 +                                                                                      4  4   2 2

E     |                                                                                                 1 1

R     |                                                                                         44    2 2213 1

C     |                                                                                          4    4  223311

E  70 +                                                                                                   22331  1

N     |                                                                                               4 4  2233

T     |                                                                                                 4   2 2  1 1

      |                                                                                                       3  2  2

S  60 +                                                                                                          33 22

U     |                                                                                                     4     311

R     |                                                                                                             112

V     |                                                                                                              11

I  50 +                                                                                                            44 11

V     |                                                                                                            33

A     |                                                                                                             34 1213

L     |                                                                                                                 212 1

   40 +                                                                                                              44

      |                                                                                                               44    1

      |                                                                                                                   2 2

      |                                                                                                                44

   30 +

      |

      |                                                                                                                 44  4

      |                                                                                                                     4

   20 +

      |

      --+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+--

        0         10         20         30         40         50         60         70         80         90         100        110



                                                                   WEEK



NOTE: 36 obs hidden.