TDMS Study 05180-07 Pathology Tables
NTP Experiment-Test: 05180-07 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC GALLIUM ARSENIDE Date: 03/09/99
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 14:17:25
2 YEAR CHRONIC MICE
Facility: Battelle Northwest
Chemical CAS #: 1303-00-0000
Lock Date: 04/11/97
Cage Range: All
Reasons For Removal: All
Removal Date Range: All
Treatment Groups: Include All
a Number of animals examined microscopically at site and number of animals with lesion
Page 1
NTP Experiment-Test: 05180-07 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC GALLIUM ARSENIDE Date: 03/09/99
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 14:17:25
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE CONTROL 0.1 0.5 1.0
MG/M3 MG/M3 MG/M3
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially In Study 50 50 50 50
Early Deaths
Moribund Sacrifice 11 11 16 11
Natural Death 3 3 2 10
Accidently Killed 2 1
Survivors
Terminal Sacrifice 36 34 31 29
Animals Examined Microscopically 50 50 50 50
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Esophagus (50) (50) (49) (50)
Inflammation, Suppurative 1 (2%)
Gallbladder (47) (45) (45) (41)
Degeneration, Hyaline 1 (2%)
Epithelium, Hyperplasia 1 (2%)
Intestine Large, Cecum (48) (49) (50) (46)
Hemorrhage 1 (2%)
Infiltration Cellular, Mast Cell 1 (2%)
Intestine Small, Jejunum (48) (47) (49) (43)
Peyer's Patch, Hyperplasia 2 (4%) 1 (2%)
Intestine Small, Ileum (48) (47) (49) (45)
Hemorrhage 1 (2%)
Inflammation 1 (2%) 1 (2%)
Peyer's Patch, Hyperplasia 1 (2%) 2 (4%) 1 (2%)
Liver (50) (50) (50) (50)
Angiectasis 1 (2%)
Clear Cell Focus 1 (2%)
Clear Cell Focus, Multiple 1 (2%)
Degeneration, Fatty 1 (2%) 1 (2%) 1 (2%) 1 (2%)
Eosinophilic Focus 3 (6%) 13 (26%) 10 (20%) 10 (20%)
Eosinophilic Focus, Multiple 2 (4%) 2 (4%) 1 (2%) 4 (8%)
Hematopoietic Cell Proliferation 3 (6%) 4 (8%) 5 (10%) 5 (10%)
Hemorrhage 1 (2%)
Hyperplasia, Lymphoid 1 (2%) 3 (6%) 1 (2%)
Inflammation 3 (6%) 1 (2%) 1 (2%)
Necrosis 3 (6%) 4 (8%) 7 (14%) 5 (10%)
Pigmentation, Hemosiderin 1 (2%)
Bile Duct, Cyst 1 (2%)
Bile Duct, Degeneration, Hyaline 1 (2%)
Oval Cell, Hyperplasia 1 (2%) 1 (2%)
Serosa, Inflammation 1 (2%)
Mesentery (8) (9) (16) (13)
Hemorrhage 1 (13%) 1 (8%)
a Number of animals examined microscopically at site and number of animals with lesion
NTP Experiment-Test: 05180-07 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC GALLIUM ARSENIDE Date: 03/09/99
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 14:17:25
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE CONTROL 0.1 0.5 1.0
MG/M3 MG/M3 MG/M3
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - CONT
Inflammation, Chronic 1 (13%) 1 (8%)
Inflammation, Suppurative 2 (13%)
Fat, Necrosis 4 (50%) 9 (100%) 13 (81%) 11 (85%)
Pancreas (50) (50) (50) (49)
Atrophy 5 (10%) 10 (20%) 11 (22%) 2 (4%)
Cytoplasmic Alteration 1 (2%) 1 (2%) 2 (4%) 1 (2%)
Hyperplasia, Lymphoid 1 (2%)
Duct, Cyst 2 (4%) 2 (4%)
Stomach, Forestomach (49) (50) (50) (49)
Hemorrhage 1 (2%)
Ulcer 1 (2%) 1 (2%) 2 (4%)
Epithelium, Hyperplasia 2 (4%) 6 (12%) 1 (2%) 2 (4%)
Stomach, Glandular (49) (50) (50) (48)
Inflammation, Suppurative 2 (4%)
Ulcer 1 (2%) 1 (2%)
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Heart (50) (50) (50) (50)
Cardiomyopathy 49 (98%) 48 (96%) 47 (94%) 47 (94%)
Artery, Inflammation 1 (2%) 1 (2%) 1 (2%)
Atrium, Thrombosis 1 (2%)
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Cortex (50) (50) (50) (49)
Hematopoietic Cell Proliferation 1 (2%) 1 (2%) 1 (2%)
Hypertrophy 5 (10%) 5 (10%) 7 (14%) 7 (14%)
Capsule, Hyperplasia 1 (2%)
Adrenal Medulla (50) (49) (50) (49)
Hyperplasia 1 (2%) 2 (4%) 1 (2%) 2 (4%)
Islets, Pancreatic (50) (50) (50) (48)
Hyperplasia 1 (2%) 1 (2%) 1 (2%) 1 (2%)
Pituitary Gland (46) (48) (50) (47)
Pars Distalis, Hyperplasia 16 (35%) 20 (42%) 20 (40%) 9 (19%)
Thyroid Gland (50) (50) (50) (49)
Follicular Cell, Hyperplasia 10 (20%) 17 (34%) 14 (28%) 12 (24%)
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
None
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
NTP Experiment-Test: 05180-07 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC GALLIUM ARSENIDE Date: 03/09/99
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 14:17:25
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE CONTROL 0.1 0.5 1.0
MG/M3 MG/M3 MG/M3
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Ovary (49) (50) (50) (46)
Angiectasis 2 (4%) 2 (4%)
Atrophy 3 (6%) 2 (4%) 2 (4%)
Cyst 18 (37%) 17 (34%) 23 (46%) 15 (33%)
Hemorrhage 1 (2%)
Hyperplasia 1 (2%)
Interstitial Stromal Tumor 1 (2%)
Thrombosis 1 (2%)
Germinal Epithelium, Hyperplasia 1 (2%)
Uterus (49) (50) (50) (50)
Angiectasis 1 (2%) 1 (2%) 2 (4%)
Hematocyst 1 (2%)
Hydrometra 2 (4%) 4 (8%) 3 (6%) 4 (8%)
Hyperplasia, Cystic 2 (4%) 2 (4%) 2 (4%) 3 (6%)
Inflammation, Suppurative 1 (2%) 1 (2%)
Thrombosis 1 (2%)
Endometrium, Hyperplasia 1 (2%)
Myometrium, Hyperplasia 2 (4%) 2 (4%) 2 (4%)
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Bone Marrow (50) (50) (50) (50)
Hyperplasia 2 (4%) 1 (2%) 2 (4%) 1 (2%)
Lymph Node (4) (8) (5) (6)
Angiectasis 2 (50%) 1 (13%) 2 (40%)
Renal, Angiectasis 1 (13%)
Renal, Hyperplasia 1 (13%) 1 (17%)
Lymph Node, Bronchial (39) (43) (42) (42)
Hyperplasia 10 (26%) 12 (28%) 13 (31%) 23 (55%)
Lymph Node, Mandibular (35) (37) (43) (43)
Hyperplasia 1 (3%) 1 (2%) 2 (5%)
Lymph Node, Mesenteric (49) (49) (50) (47)
Hyperplasia 3 (6%) 3 (6%) 5 (10%) 6 (13%)
Lymph Node, Mediastinal (40) (43) (49) (45)
Hematopoietic Cell Proliferation 2 (4%)
Hyperplasia 5 (13%) 3 (7%) 6 (12%) 8 (18%)
Spleen (50) (50) (50) (49)
Hematopoietic Cell Proliferation 23 (46%) 22 (44%) 22 (44%) 28 (57%)
Hyperplasia, Histiocytic 1 (2%)
Hyperplasia, Lymphoid 20 (40%) 12 (24%) 18 (36%) 7 (14%)
Capsule, Inflammation 1 (2%)
Thymus (43) (47) (43) (44)
Angiectasis 1 (2%)
Hyperplasia, Lymphoid 1 (2%) 1 (2%)
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
NTP Experiment-Test: 05180-07 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC GALLIUM ARSENIDE Date: 03/09/99
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 14:17:25
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE CONTROL 0.1 0.5 1.0
MG/M3 MG/M3 MG/M3
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Mammary Gland (50) (50) (50) (49)
Hyperplasia 4 (8%) 4 (8%) 2 (4%) 3 (6%)
Skin (50) (50) (50) (50)
Subcutaneous Tissue, Hemorrhage 2 (4%) 2 (4%)
Subcutaneous Tissue, Inflammation 1 (2%) 1 (2%)
Subcutaneous Tissue, Inflammation,
Granulomatous 1 (2%)
Subcutaneous Tissue, Mineralization 1 (2%)
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
Bone (50) (50) (50) (50)
Fibrous Osteodystrophy 21 (42%) 24 (48%) 14 (28%) 18 (36%)
Maxilla, Fracture 1 (2%) 1 (2%)
Skeletal Muscle (1) (2) (1) (1)
Hemorrhage 1 (50%)
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
Brain (50) (50) (50) (50)
Cyst Epithelial Inclusion 1 (2%)
Gliosis 1 (2%)
Hemorrhage 1 (2%) 1 (2%)
Meninges, Infiltration Cellular, Mononuclear
Cell 2 (4%) 5 (10%) 3 (6%) 3 (6%)
Spinal Cord (1) (1) (1)
Hyperplasia, Lymphoid 1 (100%) 1 (100%)
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Larynx (50) (50) (50) (50)
Inflammation, Suppurative 2 (4%) 2 (4%) 2 (4%) 1 (2%)
Squamous Epithelium, Hyperplasia 11 (22%) 9 (18%) 7 (14%) 7 (14%)
Lung (50) (50) (50) (50)
Congestion 1 (2%)
Hemorrhage 9 (18%) 6 (12%) 5 (10%) 5 (10%)
Infiltration Cellular, Histiocyte 2 (4%) 13 (26%) 48 (96%) 49 (98%)
Inflammation, Chronic, Focal 1 (2%) 2 (4%) 11 (22%) 18 (36%)
Inflammation, Focal, Suppurative 2 (4%) 14 (28%)
Alveolar Epithelium, Hyperplasia 2 (4%) 5 (10%) 27 (54%) 43 (86%)
Alveolus, Foreign Body 8 (16%) 48 (96%) 49 (98%)
Alveolus, Proteinosis 4 (8%) 49 (98%) 50 (100%)
a Number of animals examined microscopically at site and number of animals with lesion
NTP Experiment-Test: 05180-07 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC GALLIUM ARSENIDE Date: 03/09/99
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 14:17:25
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE CONTROL 0.1 0.5 1.0
MG/M3 MG/M3 MG/M3
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - CONT
Mediastinum, Necrosis 1 (2%)
Perivascular, Infiltration Cellular,
Mononuclear Cell 2 (4%) 2 (4%) 2 (4%)
Nose (50) (49) (50) (50)
Inflammation, Suppurative 2 (4%) 4 (8%) 4 (8%)
Olfactory Epithelium, Atrophy 3 (6%) 1 (2%) 7 (14%) 4 (8%)
Olfactory Epithelium, Degeneration, Hyaline 3 (6%) 1 (2%) 10 (20%) 5 (10%)
Olfactory Epithelium, Inflammation, Chronic 1 (2%)
Olfactory Epithelium, Metaplasia, Respiratory 1 (2%) 1 (2%)
Respiratory Epithelium, Degeneration, Hyaline 15 (30%) 17 (35%) 21 (42%) 17 (34%)
Respiratory Epithelium, Metaplasia, Squamous 2 (4%) 2 (4%)
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
Eye (1) (2) (1)
Degeneration 1 (50%)
Cornea, Inflammation, Chronic 1 (100%) 1 (50%) 1 (100%)
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (50) (50) (50) (50)
Glomerulosclerosis 2 (4%)
Hydronephrosis 1 (2%)
Inflammation, Chronic Active 1 (2%)
Metaplasia, Osseous 2 (4%) 3 (6%) 1 (2%) 1 (2%)
Nephropathy 43 (86%) 44 (88%) 40 (80%) 36 (72%)
Capsule, Inflammation 1 (2%)
Renal Tubule, Hyperplasia 1 (2%)
Urinary Bladder (48) (48) (50) (48)
Angiectasis 1 (2%)
Hyperplasia, Lymphoid 1 (2%)
Artery, Inflammation 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
NTP Experiment-Test: 05180-07 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC GALLIUM ARSENIDE Date: 03/09/99
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 14:17:25
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE CONTROL 0.1 0.5 1.0
MG/M3 MG/M3 MG/M3
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially In Study 50 50 50 50
Early Deaths
Moribund Sacrifice 7 8 10 7
Natural Death 8 4 6 9
Survivors
Terminal Sacrifice 35 38 34 34
Animals Examined Microscopically 50 50 50 50
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Gallbladder (42) (47) (41) (43)
Degeneration, Hyaline 1 (2%) 1 (2%)
Intestine Small, Jejunum (44) (48) (45) (43)
Peyer's Patch, Hyperplasia 1 (2%) 1 (2%) 1 (2%)
Intestine Small, Ileum (44) (47) (45) (42)
Peyer's Patch, Hyperplasia 1 (2%)
Liver (50) (50) (50) (50)
Basophilic Focus 1 (2%) 2 (4%) 2 (4%)
Clear Cell Focus 2 (4%) 2 (4%) 1 (2%)
Degeneration, Fatty 1 (2%) 1 (2%) 1 (2%)
Eosinophilic Focus 8 (16%) 12 (24%) 11 (22%) 14 (28%)
Eosinophilic Focus, Multiple 3 (6%) 2 (4%) 3 (6%) 5 (10%)
Hematopoietic Cell Proliferation 3 (6%) 1 (2%) 2 (4%) 2 (4%)
Inflammation 2 (4%) 3 (6%) 1 (2%)
Necrosis 10 (20%) 6 (12%) 5 (10%) 4 (8%)
Bile Duct, Cyst 1 (2%) 1 (2%)
Oval Cell, Hyperplasia 1 (2%) 1 (2%)
Mesentery (4) (5) (4) (6)
Fat, Necrosis 1 (25%) 5 (100%) 3 (75%) 6 (100%)
Pancreas (50) (50) (49) (47)
Atrophy 13 (26%) 7 (14%) 9 (18%) 6 (13%)
Inflammation 1 (2%)
Stomach, Forestomach (50) (50) (49) (49)
Ulcer 2 (4%) 1 (2%)
Epithelium, Hyperplasia 6 (12%) 2 (4%) 3 (6%) 3 (6%)
Stomach, Glandular (49) (50) (49) (48)
Infiltration Cellular, Mixed Cell 1 (2%)
Ulcer 1 (2%)
Tooth (1) (3) (1) (1)
Malformation 1 (100%) 2 (67%) 1 (100%) 1 (100%)
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
NTP Experiment-Test: 05180-07 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC GALLIUM ARSENIDE Date: 03/09/99
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 14:17:25
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE CONTROL 0.1 0.5 1.0
MG/M3 MG/M3 MG/M3
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Heart (50) (50) (50) (50)
Cardiomyopathy 48 (96%) 50 (100%) 49 (98%) 47 (94%)
Thrombosis 1 (2%)
Artery, Inflammation 1 (2%)
Atrium, Thrombosis 2 (4%)
Ventricle, Thrombosis 1 (2%)
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Cortex (50) (50) (50) (48)
Degeneration, Cystic 1 (2%)
Hyperplasia 4 (8%) 10 (20%) 7 (14%) 4 (8%)
Hypertrophy 38 (76%) 33 (66%) 38 (76%) 30 (63%)
Mineralization 1 (2%)
Adrenal Medulla (50) (50) (50) (47)
Hyperplasia 1 (2%)
Islets, Pancreatic (50) (48) (49) (47)
Hyperplasia 2 (4%) 3 (6%) 2 (4%) 4 (9%)
Pituitary Gland (48) (48) (47) (47)
Pars Distalis, Hyperplasia 1 (2%) 1 (2%) 1 (2%)
Thyroid Gland (50) (50) (50) (48)
Follicular Cell, Hyperplasia 11 (22%) 13 (26%) 7 (14%) 8 (17%)
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
None
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Epididymis (50) (50) (50) (49)
Granuloma Sperm 2 (4%) 1 (2%)
Hyperplasia 1 (2%) 1 (2%)
Inflammation 2 (4%) 1 (2%)
Preputial Gland (50) (49) (49) (48)
Ectasia 5 (10%) 3 (6%) 5 (10%) 5 (10%)
Inflammation 3 (6%) 3 (6%) 4 (8%) 9 (19%)
Prostate (50) (49) (49) (49)
Inflammation 2 (4%) 1 (2%) 1 (2%)
Seminal Vesicle (50) (50) (48) (43)
Inflammation 1 (2%) 1 (2%)
Testes (50) (50) (50) (50)
Atrophy 6 (12%) 9 (18%) 2 (4%) 2 (4%)
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
NTP Experiment-Test: 05180-07 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC GALLIUM ARSENIDE Date: 03/09/99
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 14:17:25
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE CONTROL 0.1 0.5 1.0
MG/M3 MG/M3 MG/M3
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Bone Marrow (49) (50) (50) (48)
Hyperplasia 2 (4%) 3 (6%) 2 (4%) 3 (6%)
Lymph Node (2) (2) (1)
Hyperplasia 1 (50%)
Lymph Node, Bronchial (38) (37) (40) (41)
Hyperplasia 5 (13%) 7 (19%) 17 (43%) 24 (59%)
Lymph Node, Mandibular (37) (40) (28) (32)
Hyperplasia 2 (5%) 3 (8%)
Lymph Node, Mesenteric (48) (49) (50) (46)
Angiectasis 1 (2%) 1 (2%) 1 (2%)
Erythrophagocytosis 1 (2%)
Hematopoietic Cell Proliferation 1 (2%) 1 (2%) 1 (2%) 1 (2%)
Hyperplasia 3 (6%) 5 (10%) 4 (8%) 4 (9%)
Lymph Node, Mediastinal (38) (36) (38) (33)
Hematopoietic Cell Proliferation 1 (3%)
Hyperplasia 1 (3%) 1 (3%) 4 (11%) 3 (9%)
Spleen (50) (50) (49) (47)
Hematopoietic Cell Proliferation 17 (34%) 13 (26%) 19 (39%) 18 (38%)
Hyperplasia, Lymphoid 1 (2%) 5 (10%) 3 (6%) 2 (4%)
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Skin (50) (50) (50) (50)
Cyst Epithelial Inclusion 1 (2%)
Inflammation 1 (2%) 1 (2%)
Prepuce, Inflammation, Chronic Active 2 (4%) 4 (8%) 3 (6%) 3 (6%)
Subcutaneous Tissue, Inflammation, Chronic 2 (4%)
Subcutaneous Tissue, Inflammation, Focal,
Suppurative 1 (2%)
Subcutaneous Tissue, Inflammation,
Granulomatous 1 (2%) 1 (2%) 1 (2%)
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
Bone (49) (50) (50) (50)
Fibrous Osteodystrophy 1 (2%) 2 (4%) 2 (4%)
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
NTP Experiment-Test: 05180-07 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC GALLIUM ARSENIDE Date: 03/09/99
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 14:17:25
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE CONTROL 0.1 0.5 1.0
MG/M3 MG/M3 MG/M3
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
Brain (50) (50) (50) (49)
Meninges, Infiltration Cellular, Mononuclear
Cell 1 (2%)
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Larynx (50) (50) (48) (48)
Inflammation, Suppurative 1 (2%) 1 (2%)
Metaplasia, Squamous 1 (2%)
Squamous Epithelium, Hyperplasia 11 (22%) 13 (26%) 11 (23%) 5 (10%)
Lung (50) (50) (50) (50)
Congestion 1 (2%)
Hematopoietic Cell Proliferation 1 (2%) 1 (2%)
Hemorrhage 5 (10%) 6 (12%) 6 (12%) 3 (6%)
Hyperplasia, Atypical 1 (2%)
Infiltration Cellular, Histiocyte 3 (6%) 10 (20%) 45 (90%) 48 (96%)
Inflammation, Chronic, Focal 1 (2%) 3 (6%) 3 (6%) 12 (24%)
Inflammation, Focal, Suppurative 8 (16%) 23 (46%)
Alveolar Epithelium, Hyperplasia 4 (8%) 9 (18%) 39 (78%) 45 (90%)
Alveolus, Foreign Body 4 (8%) 46 (92%) 50 (100%)
Alveolus, Proteinosis 1 (2%) 4 (8%) 49 (98%) 50 (100%)
Nose (49) (49) (49) (48)
Inflammation, Suppurative 3 (6%) 2 (4%) 1 (2%)
Olfactory Epithelium, Atrophy 7 (14%) 2 (4%) 5 (10%) 8 (17%)
Olfactory Epithelium, Degeneration, Hyaline 2 (4%) 4 (8%) 6 (12%) 1 (2%)
Respiratory Epithelium, Degeneration, Hyaline 1 (2%) 2 (4%) 2 (4%) 1 (2%)
Respiratory Epithelium, Hyperplasia 1 (2%)
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
Eye (2) (1) (4)
Degeneration 1 (100%) 2 (50%)
Cornea, Inflammation, Chronic 1 (50%)
Harderian Gland (47) (48) (49) (48)
Hyperplasia 1 (2%) 1 (2%) 10 (20%) 1 (2%)
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (50) (50) (49) (48)
Cyst 1 (2%)
Hydronephrosis 2 (4%) 3 (6%) 2 (4%) 3 (6%)
Infarct 1 (2%)
Inflammation, Chronic Active 1 (2%) 1 (2%) 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
NTP Experiment-Test: 05180-07 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC GALLIUM ARSENIDE Date: 03/09/99
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 14:17:25
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE CONTROL 0.1 0.5 1.0
MG/M3 MG/M3 MG/M3
____________________________________________________________________________________________________________________________________
URINARY SYSTEM - CONT
Metaplasia, Osseous 1 (2%) 4 (8%)
Nephropathy 48 (96%) 49 (98%) 45 (92%) 47 (98%)
Capsule, Inflammation 1 (2%) 2 (4%)
Cortex, Cyst 2 (4%) 4 (8%) 2 (4%)
Renal Tubule, Hyperplasia 2 (4%) 3 (6%) 1 (2%)
Renal Tubule, Necrosis 1 (2%)
Urinary Bladder (49) (50) (46) (46)
Inflammation 1 (2%) 2 (4%)
Transitional Epithelium, Hyperplasia 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
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