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TDMS Study 05180-07 Pathology Tables

NTP                                         STATISTICAL ANALYSIS OF SURVIVAL DATA                              REPORT: PEIRPT11     

LAB: Battelle Northwest                                     GALLIUM ARSENIDE                                   DATE: 03/09/99       

EXPERIMENT: 05180 TEST: 07                                                                                     TIME: 14:29:53       

TEST TYPE:  CHRONIC                             CAGES FROM 0000 TO LAST CAGE                                   PAGE:       1        

CONT: NO1-ES-25335                              ROUTE: RESPIRATORY EXPOSURE WHOLE BODY                         NTP C#: 62033B       

PATHOLOGIST: MILLER, RODNEY                                                                                    CAS: 1303-00-0000    

------------------------------------------------------------------------------------------------------------------------------------

                                                                                                                                    

                                                        2 YEAR CHRONIC MICE                                                         

                                                                                                                                    


               REASONS FOR REMOVAL:    ALL                                                                                          

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

               REMOVAL DATE RANGE:     ALL                                                                                          

                                                                                                                                    

               TREATMENT GROUPS:       INCLUDE ALL                                                                                  
NTP                                         STATISTICAL ANALYSIS OF SURVIVAL DATA                              REPORT: PEIRPT11    

LAB: Battelle Northwest                                     GALLIUM ARSENIDE                                   DATE: 03/09/99      

EXPERIMENT: 05180 TEST: 07                                                                                     TIME: 14:29:53      

TEST TYPE:  CHRONIC                             CAGES FROM 0000 TO LAST CAGE                                                       

CONT: NO1-ES-25335                              ROUTE: RESPIRATORY EXPOSURE WHOLE BODY                         NTP C#: 62033B      

PATHOLOGIST: MILLER, RODNEY                                                                                    CAS: 1303-00-0000   
                                 GALLIUM ARSENIDE


                       STATISTICAL ANALYSIS OF SURVIVAL DATA

                                     MALE MICE

                       FIRST TERMINAL SACRIFICE AT 733 DAYS

                                                          


                          INDIVIDUAL SURVIVAL TIMES (DAYS)

 ==================================================================================

 |                                DOSE = CONTROL                                  |

 |                             ---------------------                              |

 |                                                                                |

 |  TOTAL 50     UNCENSORED DEATHS 15     CENSORED DEATHS 0    TERMINAL 35        |

 |                                                                                |

 |  UNCENSORED DEATHS                                                             |

 |      54    457   462   561   561   570   574   578   647   686                 |

 |      699   702   707   709   727                                               |

 |  CENSORED DEATHS                                                               |

 |      NONE                                                                      |

 |                                                                                |

 |--------------------------------------------------------------------------------|

 |                          DOSE = 0.1     MG/M3                                  |

 |                       ----------------------------                             |

 |                                                                                |

 |  TOTAL 50     UNCENSORED DEATHS 12     CENSORED DEATHS 0    TERMINAL 38        |

 |                                                                                |

 |  UNCENSORED DEATHS                                                             |

 |      473   478   481   581   609   617   659   705   710   715                 |

 |      715   729                                                                 |

 |  CENSORED DEATHS                                                               |

 |      NONE                                                                      |

 |                                                                                |

 |--------------------------------------------------------------------------------|

 |                          DOSE = 0.5     MG/M3                                  |

 |                       ----------------------------                             |

 |                                                                                |

 |  TOTAL 50     UNCENSORED DEATHS 16     CENSORED DEATHS 0    TERMINAL 34        |

 |                                                                                |

 |  UNCENSORED DEATHS                                                             |

 |      232   393   502   504   548   573   586   608   609   639                 |

 |      645   645   672   692   715   729                                         |

 |  CENSORED DEATHS                                                               |

 |      NONE                                                                      |

 |                                                                                |

 ==================================================================================
                                 GALLIUM ARSENIDE


                       STATISTICAL ANALYSIS OF SURVIVAL DATA

                                     MALE MICE

                       FIRST TERMINAL SACRIFICE AT 733 DAYS

                                                          


                          INDIVIDUAL SURVIVAL TIMES (DAYS)

 ==================================================================================

 |                          DOSE = 1.0     MG/M3                                  |

 |                       ----------------------------                             |

 |                                                                                |

 |  TOTAL 50     UNCENSORED DEATHS 16     CENSORED DEATHS 0    TERMINAL 34        |

 |                                                                                |

 |  UNCENSORED DEATHS                                                             |

 |      406   501   555   561   591   599   645   656   659   665                 |

 |      699   710   716   723   729   732                                         |

 |  CENSORED DEATHS                                                               |

 |      NONE                                                                      |

 |                                                                                |

 ==================================================================================
                                 GALLIUM ARSENIDE


                       STATISTICAL ANALYSIS OF SURVIVAL DATA

                                     MALE MICE

                       FIRST TERMINAL SACRIFICE AT 733 DAYS


 ==================================================================================

 |               KAPLAN-MEIER SURVIVAL PROBABILITY ESTIMATES (%)                  |

 |                                                                                |

 |--------------------------------------------------------------------------------|

 |    DOSE                               TIME (DAYS)                              |

 |                 90   180   270   365   425   485   545   605   665   733 (A)   |

 |                                                                                |

 |--------------------------------------------------------------------------------|

 |           |                                                                    |

 |CONTROL    |    98.0  98.0  98.0  98.0  98.0  94.0  94.0  84.0  82.0  70.0      |

 |           |                                                                    |

 |           |                                                                    |

 |0.1        |   100.0 100.0 100.0 100.0 100.0  94.0  94.0  92.0  86.0  76.0      |

 |MG/M3      |                                                                    |

 |           |                                                                    |

 |0.5        |   100.0 100.0  98.0  98.0  96.0  96.0  92.0  86.0  76.0  68.0      |

 |MG/M3      |                                                                    |

 |           |                                                                    |

 |1.0        |   100.0 100.0 100.0 100.0  98.0  98.0  96.0  88.0  80.0  68.0      |

 |MG/M3      |                                                                    |

 |           |                                                                    |

 ==================================================================================

 ==================================================================================

 |                           SURVIVAL SUMMARY STATISTICS                          |

 |                                                                                |

 |                                                                                |

 |--------------------------------------------------------------------------------|

 |                                                  DOSE                          |

 |                                                                                |

 |                                CONTROL      0.1          0.5          1.0      |

 |                                             MG/M3        MG/M3        MG/M3    |

 |--------------------------------------------------------------------------------|

 |SURVIVAL AT END OF STUDY|       70.0%        76.0%        68.0%        68.0%    |

 |(KAPLAN-MEIER)          |                                                       |

 |                        |                                                       |

 |SIGNIFICANCE (B)        |       P=0.646      P=0.567N     P=0.947      P=1.000  |

 |(LIFE TABLE)            |                                                       |

 |                        |                                                       |

 |MEAN DAY OF             |       579.6        622.7        580.8        634.2    |

 |NATURAL DEATHS (C)      |       (44.0)       (28.8)       (31.9)       (23.3)   |

 |(STANDARD ERROR)        |                                                       |

 |                        |                                                       |

 |MEAN LIFE SPAN (D)      |       687.0        706.5        684.3        701.4    |

 |(STANDARD ERROR)        |       (16.3)       ( 9.5)       (14.2)       ( 9.8)   |

 |                        |                                                       |

 ==================================================================================

                                    


       (A)  FIRST TERMINAL SACRIFICE

       (B)  THE FIRST ENTRY IS THE TREND TEST (TARONE, 1975) RESULT.

            SUBSEQUENT ENTRIES ARE THE RESULTS OF PAIRWISE TESTS

            (COX,1972).  NEGATIVE TRENDS ARE INDICATED BY "N".

       (C)  MEAN OF ALL UNCENSORED DEATHS PRIOR TO TERMINAL SACRIFICE

       (D)  MEAN OF ALL DEATHS (UNCENSORED, CENSORED, TERMINAL SACRIFICE)
                                 GALLIUM ARSENIDE


                       STATISTICAL ANALYSIS OF SURVIVAL DATA

                                    FEMALE MICE

                       FIRST TERMINAL SACRIFICE AT 735 DAYS

                                                          


                          INDIVIDUAL SURVIVAL TIMES (DAYS)

 ==================================================================================

 |                                DOSE = CONTROL                                  |

 |                             ---------------------                              |

 |                                                                                |

 |  TOTAL 50     UNCENSORED DEATHS 14     CENSORED DEATHS 0    TERMINAL 36        |

 |                                                                                |

 |  UNCENSORED DEATHS                                                             |

 |      237   439   533   553   617   633   639   645   659   684                 |

 |      694   707   729   729                                                     |

 |  CENSORED DEATHS                                                               |

 |      NONE                                                                      |

 |                                                                                |

 |--------------------------------------------------------------------------------|

 |                          DOSE = 0.1     MG/M3                                  |

 |                       ----------------------------                             |

 |                                                                                |

 |  TOTAL 50     UNCENSORED DEATHS 14     CENSORED DEATHS 2    TERMINAL 34        |

 |                                                                                |

 |  UNCENSORED DEATHS                                                             |

 |      533   644   659   659   659   672   688   701   707   715                 |

 |      715   715   715   729                                                     |

 |  CENSORED DEATHS                                                               |

 |      124   302                                                                 |

 |                                                                                |

 |--------------------------------------------------------------------------------|

 |                          DOSE = 0.5     MG/M3                                  |

 |                       ----------------------------                             |

 |                                                                                |

 |  TOTAL 50     UNCENSORED DEATHS 18     CENSORED DEATHS 1    TERMINAL 31        |

 |                                                                                |

 |  UNCENSORED DEATHS                                                             |

 |      239   281   365   365   421   483   553   560   581   609                 |

 |      629   643   645   659   659   711   715   734                             |

 |  CENSORED DEATHS                                                               |

 |      623                                                                       |

 |                                                                                |

 ==================================================================================
                                 GALLIUM ARSENIDE


                       STATISTICAL ANALYSIS OF SURVIVAL DATA

                                    FEMALE MICE

                       FIRST TERMINAL SACRIFICE AT 735 DAYS

                                                          


                          INDIVIDUAL SURVIVAL TIMES (DAYS)

 ==================================================================================

 |                          DOSE = 1.0     MG/M3                                  |

 |                       ----------------------------                             |

 |                                                                                |

 |  TOTAL 50     UNCENSORED DEATHS 21     CENSORED DEATHS 0    TERMINAL 29        |

 |                                                                                |

 |  UNCENSORED DEATHS                                                             |

 |      365   412   464   490   497   505   529   595   628   646                 |

 |      646   659   673   682   702   707   710   714   717   722                 |

 |      729                                                                       |

 |  CENSORED DEATHS                                                               |

 |      NONE                                                                      |

 |                                                                                |

 ==================================================================================
                                 GALLIUM ARSENIDE


                       STATISTICAL ANALYSIS OF SURVIVAL DATA

                                    FEMALE MICE

                       FIRST TERMINAL SACRIFICE AT 735 DAYS


 ==================================================================================

 |               KAPLAN-MEIER SURVIVAL PROBABILITY ESTIMATES (%)                  |

 |                                                                                |

 |--------------------------------------------------------------------------------|

 |    DOSE                               TIME (DAYS)                              |

 |                 90   180   270   365   425   485   545   605   665   735 (A)   |

 |                                                                                |

 |--------------------------------------------------------------------------------|

 |           |                                                                    |

 |CONTROL    |   100.0 100.0  98.0  98.0  98.0  96.0  94.0  92.0  82.0  72.0      |

 |           |                                                                    |

 |           |                                                                    |

 |0.1        |   100.0 100.0 100.0 100.0 100.0 100.0  97.9  97.9  89.6  70.8      |

 |MG/M3      |                                                                    |

 |           |                                                                    |

 |0.5        |   100.0 100.0  98.0  92.0  90.0  88.0  88.0  82.0  69.7  63.6      |

 |MG/M3      |                                                                    |

 |           |                                                                    |

 |1.0        |   100.0 100.0 100.0  98.0  96.0  94.0  86.0  84.0  76.0  58.0      |

 |MG/M3      |                                                                    |

 |           |                                                                    |

 ==================================================================================

 ==================================================================================

 |                           SURVIVAL SUMMARY STATISTICS                          |

 |                                                                                |

 |                                                                                |

 |--------------------------------------------------------------------------------|

 |                                                  DOSE                          |

 |                                                                                |

 |                                CONTROL      0.1          0.5          1.0      |

 |                                             MG/M3        MG/M3        MG/M3    |

 |--------------------------------------------------------------------------------|

 |SURVIVAL AT END OF STUDY|       72.0%        70.8%        63.6%        58.0%    |

 |(KAPLAN-MEIER)          |                                                       |

 |                        |                                                       |

 |SIGNIFICANCE (B)        |       P=0.083      P=1.000N     P=0.404      P=0.200  |

 |(LIFE TABLE)            |                                                       |

 |                        |                                                       |

 |MEAN DAY OF             |       607.0        679.4        547.3        609.1    |

 |NATURAL DEATHS (C)      |       (35.8)       (13.4)       (36.1)       (24.7)   |

 |(STANDARD ERROR)        |                                                       |

 |                        |                                                       |

 |MEAN LIFE SPAN (D)      |       699.2        698.5        665.2        682.1    |

 |(STANDARD ERROR)        |       (12.7)       (15.3)       (18.1)       (13.5)   |

 |                        |                                                       |

 ==================================================================================

                                    


       (A)  FIRST TERMINAL SACRIFICE

       (B)  THE FIRST ENTRY IS THE TREND TEST (TARONE, 1975) RESULT.

            SUBSEQUENT ENTRIES ARE THE RESULTS OF PAIRWISE TESTS

            (COX,1972).  NEGATIVE TRENDS ARE INDICATED BY "N".

       (C)  MEAN OF ALL UNCENSORED DEATHS PRIOR TO TERMINAL SACRIFICE

       (D)  MEAN OF ALL DEATHS (UNCENSORED, CENSORED, TERMINAL SACRIFICE)
                                                          GALLIUM ARSENIDE

                                                    KAPLAN-MEIER SURVIVAL CURVES

                                                        CONTROL          = 1

                                                        0.1     MG/M3    = 2

                                                        0.5     MG/M3    = 3

                                                        1.0     MG/M3    = 4



------------------------------------------------------ SPECIES=MICE SEX=MALE -------------------------------------------------------



                                         Plot of SURVIVAL*WEEK.  Symbol is value of DOSE.



      |

      |

  100 + 1        1                           3                          4          2

      |

      |          1                           3                         34        1 22  4

      |

   96 +                                                                3               3        4

      |

      |                                                                          1  2           41 2

      |

P  92 +                                                                                3       3 4 2  4 2

E     |

R     |                                                                                        3 11   442 2

C     |

E  88 +                                                                                           3 3  4  2   4  2

N     |

T     |                                                                                           113   3     44 2     2

      |

S  84 +                                                                                            1          14 4     22

U     |

R     |                                                                                                 3    31     1   22

V     |

I  80 +                                                                                                      33  4  1 1

V     |

A     |                                                                                                               1142  2

L     |

   76 +                                                                                                       3   3     44  2

      |

      |                                                                                                           3  3 1144

      |

   72 +                                                                                                              3  131 4

      |

      |                                                                                                                  31 1

      |

   68 +                                                                                                                     3

      |

      --+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+--

        0         10         20         30         40         50         60         70         80         90         100        110



                                                                   WEEK



NOTE: 11 obs hidden.
                                                          GALLIUM ARSENIDE

                                                    KAPLAN-MEIER SURVIVAL CURVES

                                                        CONTROL          = 1

                                                        0.1     MG/M3    = 2

                                                        0.5     MG/M3    = 3

                                                        1.0     MG/M3    = 4



----------------------------------------------------- SPECIES=MICE SEX=FEMALE ------------------------------------------------------



                                         Plot of SURVIVAL*WEEK.  Symbol is value of DOSE.



      |

      |

  100 + 1                                    1 3                  4                          2

      |

      |                                      1 3     3            4      4   1               2               2

      |                                              3            3      4   1    4          1               2   2

   95 +

      |                                                                           4  4       1 1

      |                                                           3        3         44        1          1

      |

   90 +                                                                    3        3 4 4                 1 1    22

      |

P     |                                                                             3   4   4  3            11    2  2

E     |                                                                                     4  33     4      11

R  85 +                                                                                                              2 2

C     |                                                                                         3  3  4    4  1  1

E     |                                                                                            3    3  4  4  1  1

N     |                                                                                                                2 2

T  80 +                                                                                                 3  3        1 1

      |

S     |                                                                                                    3 34  4    11

U     |                                                                                                      33  4 4   1    1

R  75 +

V     |                                                                                                       3  3 44

I     |                                                                                                             4  4 2  1

V     |                                                                                                                     2

A  70 +                                                                                                          3      3

L     |

      |                                                                                                                433

      |                                                                                                                  3  3

   65 +

      |                                                                                                                 44  3

      |                                                                                                                  44

      |

   60 +                                                                                                                   4 4

      |

      |                                                                                                                     4

      |

   55 +

      |

      --+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+--

        0         10         20         30         40         50         60         70         80         90         100        110



                                                                   WEEK



NOTE: 5 obs hidden.