TDMS Study 05180-07 Pathology Tables
NTP STATISTICAL ANALYSIS OF SURVIVAL DATA REPORT: PEIRPT11
LAB: Battelle Northwest GALLIUM ARSENIDE DATE: 03/09/99
EXPERIMENT: 05180 TEST: 07 TIME: 14:29:53
TEST TYPE: CHRONIC CAGES FROM 0000 TO LAST CAGE PAGE: 1
CONT: NO1-ES-25335 ROUTE: RESPIRATORY EXPOSURE WHOLE BODY NTP C#: 62033B
PATHOLOGIST: MILLER, RODNEY CAS: 1303-00-0000
------------------------------------------------------------------------------------------------------------------------------------
2 YEAR CHRONIC MICE
REASONS FOR REMOVAL: ALL
REMOVAL DATE RANGE: ALL
TREATMENT GROUPS: INCLUDE ALL
NTP STATISTICAL ANALYSIS OF SURVIVAL DATA REPORT: PEIRPT11
LAB: Battelle Northwest GALLIUM ARSENIDE DATE: 03/09/99
EXPERIMENT: 05180 TEST: 07 TIME: 14:29:53
TEST TYPE: CHRONIC CAGES FROM 0000 TO LAST CAGE
CONT: NO1-ES-25335 ROUTE: RESPIRATORY EXPOSURE WHOLE BODY NTP C#: 62033B
PATHOLOGIST: MILLER, RODNEY CAS: 1303-00-0000
GALLIUM ARSENIDE
STATISTICAL ANALYSIS OF SURVIVAL DATA
MALE MICE
FIRST TERMINAL SACRIFICE AT 733 DAYS
INDIVIDUAL SURVIVAL TIMES (DAYS)
==================================================================================
| DOSE = CONTROL |
| --------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 15 CENSORED DEATHS 0 TERMINAL 35 |
| |
| UNCENSORED DEATHS |
| 54 457 462 561 561 570 574 578 647 686 |
| 699 702 707 709 727 |
| CENSORED DEATHS |
| NONE |
| |
|--------------------------------------------------------------------------------|
| DOSE = 0.1 MG/M3 |
| ---------------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 12 CENSORED DEATHS 0 TERMINAL 38 |
| |
| UNCENSORED DEATHS |
| 473 478 481 581 609 617 659 705 710 715 |
| 715 729 |
| CENSORED DEATHS |
| NONE |
| |
|--------------------------------------------------------------------------------|
| DOSE = 0.5 MG/M3 |
| ---------------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 16 CENSORED DEATHS 0 TERMINAL 34 |
| |
| UNCENSORED DEATHS |
| 232 393 502 504 548 573 586 608 609 639 |
| 645 645 672 692 715 729 |
| CENSORED DEATHS |
| NONE |
| |
==================================================================================
GALLIUM ARSENIDE
STATISTICAL ANALYSIS OF SURVIVAL DATA
MALE MICE
FIRST TERMINAL SACRIFICE AT 733 DAYS
INDIVIDUAL SURVIVAL TIMES (DAYS)
==================================================================================
| DOSE = 1.0 MG/M3 |
| ---------------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 16 CENSORED DEATHS 0 TERMINAL 34 |
| |
| UNCENSORED DEATHS |
| 406 501 555 561 591 599 645 656 659 665 |
| 699 710 716 723 729 732 |
| CENSORED DEATHS |
| NONE |
| |
==================================================================================
GALLIUM ARSENIDE
STATISTICAL ANALYSIS OF SURVIVAL DATA
MALE MICE
FIRST TERMINAL SACRIFICE AT 733 DAYS
==================================================================================
| KAPLAN-MEIER SURVIVAL PROBABILITY ESTIMATES (%) |
| |
|--------------------------------------------------------------------------------|
| DOSE TIME (DAYS) |
| 90 180 270 365 425 485 545 605 665 733 (A) |
| |
|--------------------------------------------------------------------------------|
| | |
|CONTROL | 98.0 98.0 98.0 98.0 98.0 94.0 94.0 84.0 82.0 70.0 |
| | |
| | |
|0.1 | 100.0 100.0 100.0 100.0 100.0 94.0 94.0 92.0 86.0 76.0 |
|MG/M3 | |
| | |
|0.5 | 100.0 100.0 98.0 98.0 96.0 96.0 92.0 86.0 76.0 68.0 |
|MG/M3 | |
| | |
|1.0 | 100.0 100.0 100.0 100.0 98.0 98.0 96.0 88.0 80.0 68.0 |
|MG/M3 | |
| | |
==================================================================================
==================================================================================
| SURVIVAL SUMMARY STATISTICS |
| |
| |
|--------------------------------------------------------------------------------|
| DOSE |
| |
| CONTROL 0.1 0.5 1.0 |
| MG/M3 MG/M3 MG/M3 |
|--------------------------------------------------------------------------------|
|SURVIVAL AT END OF STUDY| 70.0% 76.0% 68.0% 68.0% |
|(KAPLAN-MEIER) | |
| | |
|SIGNIFICANCE (B) | P=0.646 P=0.567N P=0.947 P=1.000 |
|(LIFE TABLE) | |
| | |
|MEAN DAY OF | 579.6 622.7 580.8 634.2 |
|NATURAL DEATHS (C) | (44.0) (28.8) (31.9) (23.3) |
|(STANDARD ERROR) | |
| | |
|MEAN LIFE SPAN (D) | 687.0 706.5 684.3 701.4 |
|(STANDARD ERROR) | (16.3) ( 9.5) (14.2) ( 9.8) |
| | |
==================================================================================
(A) FIRST TERMINAL SACRIFICE
(B) THE FIRST ENTRY IS THE TREND TEST (TARONE, 1975) RESULT.
SUBSEQUENT ENTRIES ARE THE RESULTS OF PAIRWISE TESTS
(COX,1972). NEGATIVE TRENDS ARE INDICATED BY "N".
(C) MEAN OF ALL UNCENSORED DEATHS PRIOR TO TERMINAL SACRIFICE
(D) MEAN OF ALL DEATHS (UNCENSORED, CENSORED, TERMINAL SACRIFICE)
GALLIUM ARSENIDE
STATISTICAL ANALYSIS OF SURVIVAL DATA
FEMALE MICE
FIRST TERMINAL SACRIFICE AT 735 DAYS
INDIVIDUAL SURVIVAL TIMES (DAYS)
==================================================================================
| DOSE = CONTROL |
| --------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 14 CENSORED DEATHS 0 TERMINAL 36 |
| |
| UNCENSORED DEATHS |
| 237 439 533 553 617 633 639 645 659 684 |
| 694 707 729 729 |
| CENSORED DEATHS |
| NONE |
| |
|--------------------------------------------------------------------------------|
| DOSE = 0.1 MG/M3 |
| ---------------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 14 CENSORED DEATHS 2 TERMINAL 34 |
| |
| UNCENSORED DEATHS |
| 533 644 659 659 659 672 688 701 707 715 |
| 715 715 715 729 |
| CENSORED DEATHS |
| 124 302 |
| |
|--------------------------------------------------------------------------------|
| DOSE = 0.5 MG/M3 |
| ---------------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 18 CENSORED DEATHS 1 TERMINAL 31 |
| |
| UNCENSORED DEATHS |
| 239 281 365 365 421 483 553 560 581 609 |
| 629 643 645 659 659 711 715 734 |
| CENSORED DEATHS |
| 623 |
| |
==================================================================================
GALLIUM ARSENIDE
STATISTICAL ANALYSIS OF SURVIVAL DATA
FEMALE MICE
FIRST TERMINAL SACRIFICE AT 735 DAYS
INDIVIDUAL SURVIVAL TIMES (DAYS)
==================================================================================
| DOSE = 1.0 MG/M3 |
| ---------------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 21 CENSORED DEATHS 0 TERMINAL 29 |
| |
| UNCENSORED DEATHS |
| 365 412 464 490 497 505 529 595 628 646 |
| 646 659 673 682 702 707 710 714 717 722 |
| 729 |
| CENSORED DEATHS |
| NONE |
| |
==================================================================================
GALLIUM ARSENIDE
STATISTICAL ANALYSIS OF SURVIVAL DATA
FEMALE MICE
FIRST TERMINAL SACRIFICE AT 735 DAYS
==================================================================================
| KAPLAN-MEIER SURVIVAL PROBABILITY ESTIMATES (%) |
| |
|--------------------------------------------------------------------------------|
| DOSE TIME (DAYS) |
| 90 180 270 365 425 485 545 605 665 735 (A) |
| |
|--------------------------------------------------------------------------------|
| | |
|CONTROL | 100.0 100.0 98.0 98.0 98.0 96.0 94.0 92.0 82.0 72.0 |
| | |
| | |
|0.1 | 100.0 100.0 100.0 100.0 100.0 100.0 97.9 97.9 89.6 70.8 |
|MG/M3 | |
| | |
|0.5 | 100.0 100.0 98.0 92.0 90.0 88.0 88.0 82.0 69.7 63.6 |
|MG/M3 | |
| | |
|1.0 | 100.0 100.0 100.0 98.0 96.0 94.0 86.0 84.0 76.0 58.0 |
|MG/M3 | |
| | |
==================================================================================
==================================================================================
| SURVIVAL SUMMARY STATISTICS |
| |
| |
|--------------------------------------------------------------------------------|
| DOSE |
| |
| CONTROL 0.1 0.5 1.0 |
| MG/M3 MG/M3 MG/M3 |
|--------------------------------------------------------------------------------|
|SURVIVAL AT END OF STUDY| 72.0% 70.8% 63.6% 58.0% |
|(KAPLAN-MEIER) | |
| | |
|SIGNIFICANCE (B) | P=0.083 P=1.000N P=0.404 P=0.200 |
|(LIFE TABLE) | |
| | |
|MEAN DAY OF | 607.0 679.4 547.3 609.1 |
|NATURAL DEATHS (C) | (35.8) (13.4) (36.1) (24.7) |
|(STANDARD ERROR) | |
| | |
|MEAN LIFE SPAN (D) | 699.2 698.5 665.2 682.1 |
|(STANDARD ERROR) | (12.7) (15.3) (18.1) (13.5) |
| | |
==================================================================================
(A) FIRST TERMINAL SACRIFICE
(B) THE FIRST ENTRY IS THE TREND TEST (TARONE, 1975) RESULT.
SUBSEQUENT ENTRIES ARE THE RESULTS OF PAIRWISE TESTS
(COX,1972). NEGATIVE TRENDS ARE INDICATED BY "N".
(C) MEAN OF ALL UNCENSORED DEATHS PRIOR TO TERMINAL SACRIFICE
(D) MEAN OF ALL DEATHS (UNCENSORED, CENSORED, TERMINAL SACRIFICE)
GALLIUM ARSENIDE
KAPLAN-MEIER SURVIVAL CURVES
CONTROL = 1
0.1 MG/M3 = 2
0.5 MG/M3 = 3
1.0 MG/M3 = 4
------------------------------------------------------ SPECIES=MICE SEX=MALE -------------------------------------------------------
Plot of SURVIVAL*WEEK. Symbol is value of DOSE.
|
|
100 + 1 1 3 4 2
|
| 1 3 34 1 22 4
|
96 + 3 3 4
|
| 1 2 41 2
|
P 92 + 3 3 4 2 4 2
E |
R | 3 11 442 2
C |
E 88 + 3 3 4 2 4 2
N |
T | 113 3 44 2 2
|
S 84 + 1 14 4 22
U |
R | 3 31 1 22
V |
I 80 + 33 4 1 1
V |
A | 1142 2
L |
76 + 3 3 44 2
|
| 3 3 1144
|
72 + 3 131 4
|
| 31 1
|
68 + 3
|
--+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+--
0 10 20 30 40 50 60 70 80 90 100 110
WEEK
NOTE: 11 obs hidden.
GALLIUM ARSENIDE
KAPLAN-MEIER SURVIVAL CURVES
CONTROL = 1
0.1 MG/M3 = 2
0.5 MG/M3 = 3
1.0 MG/M3 = 4
----------------------------------------------------- SPECIES=MICE SEX=FEMALE ------------------------------------------------------
Plot of SURVIVAL*WEEK. Symbol is value of DOSE.
|
|
100 + 1 1 3 4 2
|
| 1 3 3 4 4 1 2 2
| 3 3 4 1 4 1 2 2
95 +
| 4 4 1 1
| 3 3 44 1 1
|
90 + 3 3 4 4 1 1 22
|
P | 3 4 4 3 11 2 2
E | 4 33 4 11
R 85 + 2 2
C | 3 3 4 4 1 1
E | 3 3 4 4 1 1
N | 2 2
T 80 + 3 3 1 1
|
S | 3 34 4 11
U | 33 4 4 1 1
R 75 +
V | 3 3 44
I | 4 4 2 1
V | 2
A 70 + 3 3
L |
| 433
| 3 3
65 +
| 44 3
| 44
|
60 + 4 4
|
| 4
|
55 +
|
--+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+--
0 10 20 30 40 50 60 70 80 90 100 110
WEEK
NOTE: 5 obs hidden.