TDMS Study 05181-04 Pathology Tables
NTP Experiment-Test: 05181-04 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC TETRAHYDROFURAN Date: 02/21/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:46:29
CORE STUDY
Facility: Battelle Northwest
Chemical CAS #: 0109-99-9
Lock Date: 03/24/93
Cage Range: All
Reasons For Removal: All
Removal Date Range: All
Treatment Groups: Include All
a Number of animals examined microscopically at site and number of animals with lesion
Page 1
NTP Experiment-Test: 05181-04 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC TETRAHYDROFURAN Date: 02/21/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:46:29
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE CONTROL 200 PPM 600 PPM 1800 PPM
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially In Study 50 50 50 50
Early Deaths
Accidently Killed 5 1 1
Moribund Sacrifice 13 10 20 13
Natural Death 3 6 3 5
Survivors
Terminal Sacrifice 29 33 26 32
Animals Examined Microscopically 50 50 50 50
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Gallbladder (45) (44) (45) (44)
Degeneration, Hyaline 1 (2%)
Inflammation 1 (2%) 1 (2%)
Intestine Small, Ileum (46) (45) (46) (46)
Diverticulum 1 (2%)
Ulcer 1 (2%)
Liver (50) (50) (50) (48)
Angiectasis 1 (2%) 1 (2%) 1 (2%)
Basophilic Focus 1 (2%) 1 (2%)
Clear Cell Focus 1 (2%) 1 (2%)
Eosinophilic Focus 7 (14%) 9 (18%) 7 (14%) 11 (23%)
Hematopoietic Cell Proliferation 1 (2%) 2 (4%) 3 (6%)
Hemorrhage 1 (2%)
Hepatodiaphragmatic Nodule 1 (2%) 1 (2%)
Inflammation, Chronic 1 (2%) 1 (2%) 1 (2%)
Mixed Cell Focus 3 (6%) 1 (2%)
Necrosis 3 (6%) 7 (15%)
Pigmentation 1 (2%)
Thrombosis 1 (2%)
Vacuolization Cytoplasmic, Focal 1 (2%)
Bile Duct, Cyst 1 (2%) 1 (2%)
Mesentery (6) (9) (9) (9)
Inflammation, Chronic 1 (11%)
Fat, Hemorrhage 1 (11%)
Fat, Necrosis 3 (50%) 6 (67%) 4 (44%) 7 (78%)
Pancreas (48) (49) (48) (46)
Atrophy 1 (2%) 2 (4%) 1 (2%) 1 (2%)
Basophilic Focus 1 (2%)
Cytoplasmic Alteration 1 (2%) 1 (2%)
Hyperplasia 1 (2%) 2 (4%) 2 (4%)
Hypertrophy 1 (2%) 1 (2%) 1 (2%) 2 (4%)
Inflammation 1 (2%)
Duct, Cyst 1 (2%) 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 2
NTP Experiment-Test: 05181-04 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC TETRAHYDROFURAN Date: 02/21/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:46:29
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE CONTROL 200 PPM 600 PPM 1800 PPM
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - CONT
Stomach, Forestomach (50) (49) (49) (47)
Angiectasis 1 (2%)
Infiltration Cellular, Mast Cell 1 (2%)
Inflammation 1 (2%)
Ulcer 3 (6%) 1 (2%) 2 (4%)
Epithelium, Hyperplasia 2 (4%) 1 (2%) 1 (2%)
Stomach, Glandular (49) (48) (48) (47)
Erosion 2 (4%) 1 (2%) 2 (4%)
Infiltration Cellular, Mast Cell 1 (2%)
Inflammation, Suppurative 1 (2%) 1 (2%)
Mineralization 1 (2%)
Ulcer 1 (2%)
Epithelium, Hyperplasia 1 (2%)
Tooth (1)
Developmental Malformation 1 (100%)
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Blood Vessel (1) (1)
Inflammation 1 (100%)
Mineralization 1 (100%)
Heart (50) (50) (50) (48)
Cardiomyopathy 17 (34%) 28 (56%) 25 (50%) 22 (46%)
Hemorrhage 1 (2%)
Mineralization 1 (2%) 1 (2%)
Artery, Inflammation 1 (2%) 2 (4%) 1 (2%)
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Cortex (50) (50) (50) (46)
Hematopoietic Cell Proliferation 1 (2%) 1 (2%)
Hyperplasia 2 (4%) 1 (2%)
Hypertrophy 3 (6%) 4 (8%) 5 (10%) 3 (7%)
Necrosis 1 (2%) 1 (2%)
Capsule, Hyperplasia 1 (2%) 1 (2%) 1 (2%)
Adrenal Medulla (49) (49) (50) (45)
Hyperplasia 4 (8%) 8 (16%) 1 (2%) 1 (2%)
Necrosis 1 (2%) 1 (2%)
Islets, Pancreatic (48) (49) (47) (46)
Hyperplasia 1 (2%)
Parathyroid Gland (30) (33) (33) (34)
Cyst 1 (3%)
Pituitary Gland (47) (48) (48) (48)
Hyperplasia 1 (2%)
Pars Distalis, Cyst 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 3
NTP Experiment-Test: 05181-04 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC TETRAHYDROFURAN Date: 02/21/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:46:29
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE CONTROL 200 PPM 600 PPM 1800 PPM
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - CONT
Pars Distalis, Hyperplasia 14 (30%) 12 (25%) 16 (33%) 20 (42%)
Pars Intermedia, Hyperplasia 1 (2%) 3 (6%)
Thyroid Gland (50) (50) (49) (47)
Angiectasis 1 (2%)
Inflammation 1 (2%)
C-Cell, Hyperplasia 1 (2%)
Follicular Cell, Hyperplasia 14 (28%) 10 (20%) 15 (31%) 10 (21%)
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
Peritoneum (1)
Inflammation, Suppurative 1 (100%)
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Clitoral Gland (38) (40) (43) (41)
Inflammation 1 (3%) 1 (3%)
Ovary (49) (50) (50) (46)
Amyloid Deposition 1 (2%)
Angiectasis 3 (6%) 1 (2%)
Atrophy 8 (16%) 5 (10%) 9 (18%) 9 (20%)
Cyst 19 (39%) 15 (30%) 14 (28%) 17 (37%)
Hyperplasia 1 (2%)
Inflammation 1 (2%)
Pigmentation, Hemosiderin 1 (2%)
Artery, Inflammation 1 (2%)
Corpus Luteum, Hyperplasia 1 (2%)
Granulosa Cell, Hyperplasia 1 (2%)
Interstitial Cell, Hyperplasia 1 (2%) 1 (2%)
Uterus (49) (50) (49) (49)
Adenomyosis 1 (2%)
Angiectasis 1 (2%) 2 (4%) 1 (2%) 3 (6%)
Hydrometra 3 (6%) 5 (10%) 11 (22%)
Hyperplasia, Cystic 41 (84%) 41 (82%) 44 (90%) 41 (84%)
Inflammation, Suppurative 1 (2%) 2 (4%)
Thrombosis 1 (2%) 1 (2%)
Endometrium, Hyperplasia 1 (2%) 1 (2%) 1 (2%)
Serosa, Cyst 1 (2%)
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
Page 4
NTP Experiment-Test: 05181-04 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC TETRAHYDROFURAN Date: 02/21/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:46:29
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE CONTROL 200 PPM 600 PPM 1800 PPM
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Bone Marrow (49) (50) (49) (46)
Angiectasis 1 (2%)
Hyperplasia 4 (8%) 2 (4%)
Hyperplasia, Histiocytic 2 (4%)
Infiltration Cellular, Mast Cell 1 (2%)
Lymph Node (5) (4) (4) (2)
Degeneration, Cystic 1 (25%)
Hemorrhage 1 (25%)
Iliac, Hyperplasia 2 (40%) 1 (25%)
Lumbar, Angiectasis 1 (50%)
Lumbar, Hyperplasia 1 (20%)
Renal, Hyperplasia 1 (25%)
Lymph Node, Bronchial (36) (41) (39) (41)
Hyperplasia 1 (3%) 3 (7%) 6 (15%) 2 (5%)
Lymph Node, Mandibular (40) (41) (39) (41)
Hyperplasia 5 (13%) 2 (5%) 4 (10%) 3 (7%)
Pigmentation, Hemosiderin 1 (2%)
Lymph Node, Mesenteric (45) (46) (47) (45)
Angiectasis 1 (2%) 1 (2%)
Hematopoietic Cell Proliferation 1 (2%)
Hyperplasia 2 (4%) 3 (7%) 5 (11%) 3 (7%)
Lymph Node, Mediastinal (37) (36) (41) (38)
Hematopoietic Cell Proliferation 1 (3%)
Hyperplasia 3 (8%) 4 (10%) 1 (3%)
Spleen (49) (50) (49) (46)
Angiectasis 1 (2%)
Hematopoietic Cell Proliferation 10 (20%) 8 (16%) 10 (20%) 8 (17%)
Hyperplasia, Lymphoid 4 (8%) 1 (2%) 2 (4%) 2 (4%)
Infiltration Cellular, Mast Cell 1 (2%)
Thymus (40) (44) (38) (44)
Amyloid Deposition 1 (3%)
Angiectasis 1 (2%)
Atrophy 5 (13%) 3 (7%) 3 (8%) 2 (5%)
Hyperplasia, Lymphoid 1 (3%) 1 (2%) 1 (3%) 2 (5%)
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Mammary Gland (48) (49) (50) (50)
Hyperplasia 1 (2%) 1 (2%)
Skin (49) (50) (50) (50)
Inflammation, Suppurative 1 (2%)
Epidermis, Hyperplasia 1 (2%)
Subcutaneous Tissue, Angiectasis 1 (2%)
Subcutaneous Tissue, Edema 1 (2%)
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
Page 5
NTP Experiment-Test: 05181-04 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC TETRAHYDROFURAN Date: 02/21/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:46:29
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE CONTROL 200 PPM 600 PPM 1800 PPM
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
Bone (50) (50) (50) (49)
Arthrosis 2 (4%)
Fibrous Osteodystrophy 19 (38%) 23 (46%) 16 (32%) 15 (31%)
Cranium, Fracture 1 (2%)
Vertebra, Fracture 1 (2%)
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
Brain (50) (50) (50) (49)
Hemorrhage 1 (2%) 1 (2%)
Hydrocephalus 1 (2%)
Meninges, Infiltration Cellular, Mononuclear
Cell 1 (2%) 2 (4%) 1 (2%) 3 (6%)
Spinal Cord (1) (1)
Degeneration 1 (100%)
Hemorrhage 1 (100%)
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (50) (50) (50) (49)
Hemorrhage 1 (2%)
Infiltration Cellular, Histiocyte 2 (4%) 3 (6%) 1 (2%) 2 (4%)
Inflammation, Chronic, Focal 2 (4%) 2 (4%)
Alveolar Epithelium, Hyperplasia 2 (4%) 4 (8%) 2 (4%) 1 (2%)
Mediastinum, Inflammation 1 (2%)
Perivascular, Infiltration Cellular,
Mononuclear Cell 1 (2%) 3 (6%)
Nose (50) (50) (48) (49)
Inflammation, Suppurative 2 (4%)
Nasolacrimal Duct, Inflammation, Suppurative 1 (2%) 1 (2%)
Olfactory Epithelium, Atrophy, Focal 3 (6%) 1 (2%)
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
None
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
Page 6
NTP Experiment-Test: 05181-04 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC TETRAHYDROFURAN Date: 02/21/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:46:29
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE CONTROL 200 PPM 600 PPM 1800 PPM
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (50) (49) (49) (46)
Amyloid Deposition 1 (2%) 2 (4%)
Glomerulosclerosis 1 (2%)
Hydronephrosis 1 (2%) 1 (2%)
Hyperplasia, Lymphoid 2 (4%) 1 (2%)
Metaplasia, Osseous 1 (2%) 3 (6%) 2 (4%)
Nephropathy 17 (34%) 17 (35%) 19 (39%) 13 (28%)
Pigmentation 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 7
NTP Experiment-Test: 05181-04 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC TETRAHYDROFURAN Date: 02/21/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:46:29
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE CONTROL 200 PPM 600 PPM 1800 PPM
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially In Study 50 50 50 50
Early Deaths
Natural Death 7 7 4 14
Moribund Sacrifice 11 12 18 24
Survivors
Terminal Sacrifice 32 31 28 12
Animals Examined Microscopically 50 50 50 50
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Gallbladder (42) (46) (44) (38)
Degeneration, Hyaline 1 (2%) 1 (2%)
Inflammation 1 (2%) 1 (2%)
Epithelium, Hyperplasia 1 (2%) 1 (3%)
Intestine Large, Cecum (47) (47) (46) (40)
Muscularis, Hyperplasia 1 (3%)
Intestine Small, Duodenum (44) (45) (45) (40)
Ulcer 1 (2%)
Epithelium, Hyperplasia 1 (2%)
Intestine Small, Jejunum (45) (45) (46) (37)
Peyer's Patch, Hyperplasia 1 (2%) 1 (2%)
Intestine Small, Ileum (46) (46) (46) (40)
Peyer's Patch, Hyperplasia 1 (2%)
Peyer's Patch, Inflammation 1 (2%)
Liver (50) (50) (50) (50)
Angiectasis 1 (2%)
Basophilic Focus 1 (2%) 1 (2%)
Clear Cell Focus 2 (4%) 2 (4%)
Congestion 2 (4%)
Degeneration, Fatty, Focal 1 (2%)
Eosinophilic Focus 11 (22%) 8 (16%) 10 (20%) 5 (10%)
Hematopoietic Cell Proliferation 1 (2%) 1 (2%)
Infiltration Cellular, Histiocyte 1 (2%)
Inflammation, Chronic 1 (2%) 1 (2%)
Mixed Cell Focus 1 (2%) 1 (2%)
Necrosis 8 (16%) 5 (10%) 6 (12%) 4 (8%)
Centrilobular, Necrosis 1 (2%)
Mesentery (3) (3) (2)
Fat, Necrosis 2 (67%) 1 (33%) 1 (50%)
Pancreas (48) (48) (46) (48)
Amyloid Deposition 1 (2%)
Atrophy 1 (2%) 4 (8%) 1 (2%)
Basophilic Focus 1 (2%)
Cytoplasmic Alteration 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 8
NTP Experiment-Test: 05181-04 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC TETRAHYDROFURAN Date: 02/21/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:46:29
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE CONTROL 200 PPM 600 PPM 1800 PPM
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - CONT
Hypertrophy 1 (2%) 1 (2%)
Salivary Glands (50) (50) (50) (50)
Basophilic Focus 1 (2%)
Stomach, Forestomach (49) (50) (48) (49)
Hyperplasia 1 (2%)
Ulcer 1 (2%) 1 (2%)
Epithelium, Hyperplasia 1 (2%) 1 (2%)
Stomach, Glandular (48) (48) (46) (48)
Degeneration, Hyaline 1 (2%)
Erosion 1 (2%) 3 (6%)
Infiltration Cellular, Mast Cell 1 (2%)
Inflammation, Suppurative 2 (4%)
Mineralization 1 (2%)
Epithelium, Hyperplasia 2 (4%)
Tooth (1) (2)
Developmental Malformation 1 (100%) 1 (50%)
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Blood Vessel (1)
Aorta, Inflammation 1 (100%)
Aorta, Pigmentation, Hemosiderin 1 (100%)
Heart (49) (50) (50) (50)
Cardiomyopathy 28 (57%) 36 (72%) 35 (70%) 14 (28%)
Hyperplasia, Atypical 1 (2%)
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Cortex (48) (50) (49) (50)
Hemorrhage 1 (2%)
Hyperplasia 7 (15%) 5 (10%) 6 (12%) 2 (4%)
Hypertrophy 20 (42%) 24 (48%) 19 (39%) 10 (20%)
Capsule, Hyperplasia 1 (2%) 1 (2%)
Adrenal Medulla (48) (50) (49) (50)
Hyperplasia 2 (4%) 1 (2%)
Islets, Pancreatic (48) (48) (46) (48)
Hyperplasia 6 (13%) 2 (4%) 3 (7%) 2 (4%)
Pituitary Gland (45) (47) (45) (47)
Pars Distalis, Cyst 5 (11%) 1 (2%) 1 (2%)
Pars Distalis, Hyperplasia 2 (4%) 2 (4%) 1 (2%)
Thyroid Gland (49) (50) (49) (49)
Follicular Cell, Hyperplasia 16 (33%) 12 (24%) 9 (18%) 3 (6%)
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
Page 9
NTP Experiment-Test: 05181-04 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC TETRAHYDROFURAN Date: 02/21/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:46:29
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE CONTROL 200 PPM 600 PPM 1800 PPM
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
None
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Coagulating Gland (1) (1)
Inflammation, Suppurative 1 (100%)
Epididymis (49) (50) (50) (50)
Granuloma Sperm 1 (2%) 1 (2%)
Inflammation 1 (2%) 1 (2%)
Penis (1) (2) (2) (27)
Congestion 1 (4%)
Inflammation, Suppurative 1 (50%) 1 (50%) 9 (33%)
Preputial Gland (50) (49) (50) (48)
Cyst 5 (10%) 3 (6%) 1 (2%) 1 (2%)
Inflammation 8 (16%) 16 (33%) 9 (18%) 9 (19%)
Duct, Hyperplasia 1 (2%)
Prostate (48) (43) (44) (47)
Inflammation, Suppurative 3 (6%) 4 (9%) 4 (9%) 14 (30%)
Seminal Vesicle (48) (48) (46) (46)
Angiectasis 1 (2%)
Inflammation, Chronic 2 (4%)
Inflammation, Suppurative 1 (2%)
Testes (50) (50) (50) (50)
Atrophy 5 (10%) 3 (6%) 2 (4%) 2 (4%)
Mineralization 1 (2%)
Interstitial Cell, Hyperplasia 1 (2%) 1 (2%)
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Bone Marrow (49) (50) (49) (50)
Angiectasis 1 (2%)
Hyperplasia 5 (10%) 6 (12%) 7 (14%) 14 (28%)
Infiltration Cellular, Mast Cell 2 (4%)
Lymph Node (1) (4) (4) (5)
Iliac, Hyperplasia 3 (75%) 3 (75%) 5 (100%)
Renal, Hyperplasia 1 (100%) 1 (25%)
Lymph Node, Bronchial (33) (32) (36) (26)
Hyperplasia 2 (6%) 3 (9%) 1 (3%)
Lymph Node, Mandibular (42) (40) (43) (35)
Hyperplasia 4 (10%) 1 (3%)
Lymph Node, Mesenteric (47) (48) (46) (41)
Angiectasis 2 (4%) 1 (2%) 1 (2%)
Congestion 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 10
NTP Experiment-Test: 05181-04 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC TETRAHYDROFURAN Date: 02/21/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:46:29
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE CONTROL 200 PPM 600 PPM 1800 PPM
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - CONT
Hematopoietic Cell Proliferation 2 (4%) 2 (4%)
Hyperplasia 3 (6%) 1 (2%) 3 (7%) 1 (2%)
Lymph Node, Mediastinal (36) (40) (39) (32)
Hyperplasia 2 (5%) 1 (3%)
Spleen (48) (49) (47) (49)
Atrophy 1 (2%)
Hematopoietic Cell Proliferation 9 (19%) 13 (27%) 14 (30%) 18 (37%)
Hyperplasia, Lymphoid 5 (10%) 2 (4%) 3 (6%)
Thymus (35) (37) (34) (36)
Atrophy 2 (6%) 2 (5%) 4 (12%) 9 (25%)
Hyperplasia, Lymphoid 1 (3%)
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Skin (47) (50) (48) (50)
Inflammation, Suppurative 1 (2%) 2 (4%)
Prepuce, Inflammation, Suppurative 7 (15%) 7 (14%) 7 (15%) 18 (36%)
Subcutaneous Tissue, Infiltration Cellular,
Mast Cell 1 (2%)
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
Bone (50) (50) (50) (50)
Fibrous Osteodystrophy 3 (6%) 2 (4%) 2 (4%) 1 (2%)
Synovial Tissue, Inflammation, Chronic 1 (2%)
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
None
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Larynx (48) (49) (48) (48)
Epiglottis, Metaplasia, Squamous 2 (4%) 1 (2%)
Lung (50) (50) (50) (50)
Hemorrhage 1 (2%)
Infiltration Cellular, Histiocyte 5 (10%) 7 (14%) 7 (14%) 1 (2%)
Inflammation, Chronic, Focal 2 (4%) 1 (2%)
Pigmentation, Hemosiderin 1 (2%)
Thrombosis 1 (2%)
Alveolar Epithelium, Hyperplasia 6 (12%) 1 (2%) 1 (2%) 1 (2%)
Perivascular, Infiltration Cellular,
Mononuclear Cell 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 11
NTP Experiment-Test: 05181-04 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC TETRAHYDROFURAN Date: 02/21/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:46:29
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE CONTROL 200 PPM 600 PPM 1800 PPM
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - CONT
Nose (48) (50) (50) (50)
Fibrosis 1 (2%)
Inflammation, Suppurative 3 (6%) 2 (4%) 4 (8%)
Nasolacrimal Duct, Inflammation, Suppurative 3 (6%) 1 (2%) 2 (4%)
Olfactory Epithelium, Atrophy, Focal 2 (4%) 1 (2%) 4 (8%) 1 (2%)
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
None
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (49) (50) (49) (50)
Glomerulosclerosis 2 (4%)
Hydronephrosis 3 (6%) 3 (6%) 5 (10%) 18 (36%)
Inflammation, Suppurative 3 (6%) 5 (10%) 5 (10%) 18 (36%)
Metaplasia, Osseous 1 (2%) 2 (4%) 3 (6%)
Mineralization 1 (2%)
Nephropathy 31 (63%) 40 (80%) 33 (67%) 14 (28%)
Cortex, Cyst 2 (4%) 1 (2%) 1 (2%)
Pelvis, Necrosis 3 (6%)
Renal Tubule, Hyperplasia 2 (4%) 2 (4%) 1 (2%)
Renal Tubule, Hypertrophy 1 (2%)
Renal Tubule, Necrosis 2 (4%)
Ureter (1)
Inflammation, Suppurative 1 (100%)
Urethra (3) (1) (14)
Inflammation, Suppurative 3 (100%) 1 (100%) 12 (86%)
Necrosis 1 (100%) 5 (36%)
Urinary Bladder (48) (49) (46) (48)
Calculus Gross Observation 3 (6%)
Calculus Micro Observation Only 1 (2%) 2 (4%)
Inflammation, Suppurative 3 (6%) 6 (12%) 6 (13%) 16 (33%)
Transitional Epithelium, Hyperplasia 1 (2%) 1 (2%) 5 (10%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 12
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