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TDMS Study 05181-04 Pathology Tables

NTP Experiment-Test: 05181-04  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                          TETRAHYDROFURAN                                      Date: 02/21/96
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 12:11:24

                                                           CORE STUDY




       Facility:  Battelle Northwest

       Chemical CAS #:  0109-99-9

       Lock Date:  03/24/93

       Cage Range:  All

       Reasons For Removal:    All

       Removal Date Range:     All

       Treatment Groups:       Include All


































a  Number of animals examined microscopically at site and number of animals with lesion

                                                              Page   1

NTP Experiment-Test: 05181-04  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                          TETRAHYDROFURAN                                      Date: 02/21/96  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 12:11:24  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE FEMALE                        CONTROL      200 PPM      600 PPM      1800 PPM                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
DISPOSITION SUMMARY                                                                                                                 
  Animals Initially in Study                          50           50           50           50                                     
  Early Deaths                                                                                                                      
    Accidently Killed                                  5            1            1                                                  
    Moribund Sacrifice                                13           10           20           13                                     
    Natural Death                                      3            6            3            5                                     
  Survivors                                                                                                                         
    Terminal Sacrifice                                29           33           26           32                                     
  Animals Examined Microscopically                    50           50           50           50                                     
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Intestine Small, Duodenum                          (45)         (44)         (46)         (46)                                   
   Intestine Small, Jejunum                           (45)         (44)         (46)         (46)                                   
      Carcinoma                                                                               1 (2%)                                
      Polyp Adenomatous                                             1 (2%)                                                          
   Intestine Small, Ileum                             (46)         (45)         (46)         (46)                                   
   Liver                                              (50)         (50)         (50)         (48)                                   
      Carcinoma, Metastatic, Islets, Pancreatic                     1 (2%)                                                          
      Hemangiosarcoma                                               1 (2%)                                                          
      Hepatocellular Carcinoma                         4 (8%)       6 (12%)      9 (18%)     10 (21%)                               
      Hepatocellular Carcinoma, Multiple               2 (4%)       4 (8%)       1 (2%)       6 (13%)                               
      Hepatocellular Adenoma                          10 (20%)     14 (28%)     13 (26%)     19 (40%)                               
      Hepatocellular Adenoma, Multiple                 2 (4%)       3 (6%)       5 (10%)     12 (25%)                               
      Hepatocholangiocarcinoma                         1 (2%)       1 (2%)                                                          
      Hepatocholangiocarcinoma, Multiple               1 (2%)                                                                       
      Histiocytic Sarcoma                              3 (6%)                                                                       
      Osteosarcoma, Metastatic, Bone                                                          1 (2%)                                
   Mesentery                                          (6)          (9)          (9)          (9)                                    
      Carcinoma, Metastatic, Islets, Pancreatic                     1 (11%)                                                         
      Carcinoma, Metastatic, Ovary                                               1 (11%)                                            
      Fibrous Histiocytoma                                                                    1 (11%)                               
      Hemangiosarcoma                                               1 (11%)      1 (11%)                                            
      Histiocytic Sarcoma                              1 (17%)                   1 (11%)                                            
      Sarcoma                                          1 (17%)                                                                      
   Oral Mucosa                                                                               (1)                                    
      Squamous Cell Carcinoma                                                                 1 (100%)                              
   Pancreas                                           (48)         (49)         (48)         (46)                                   
      Carcinoma, Metastatic, Islets, Pancreatic                     1 (2%)                                                          
      Carcinoma, Metastatic, Ovary                                               1 (2%)                                             
      Fibrous Histiocytoma, Metastatic, Mesentery                                             1 (2%)                                
      Histiocytic Sarcoma                                                        1 (2%)                                             
   Salivary Glands                                    (50)         (50)         (50)         (48)                                   
   Stomach, Forestomach                               (50)         (49)         (49)         (47)                                   
                                                             Page   2                                                               
NTP Experiment-Test: 05181-04  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                          TETRAHYDROFURAN                                      Date: 02/21/96  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 12:11:24  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE FEMALE                        CONTROL      200 PPM      600 PPM      1800 PPM                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ALIMENTARY SYSTEM - cont                                                                                                            
      Squamous Cell Papilloma                          1 (2%)       2 (4%)                                                          
   Stomach, Glandular                                 (49)         (48)         (48)         (47)                                   
      Carcinoma, Metastatic, Ovary                                               1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Heart                                              (50)         (50)         (50)         (48)                                   
      Hemangiosarcoma                                  1 (2%)                                                                       
      Hepatocholangiocarcinoma, Metastatic, Liver                   1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Cortex                                     (50)         (50)         (50)         (46)                                   
   Adrenal Medulla                                    (49)         (49)         (50)         (45)                                   
      Hepatocellular Carcinoma, Metastatic, Liver      1 (2%)                                                                       
      Pheochromocytoma Malignant                                                 1 (2%)                                             
      Pheochromocytoma Benign                                       1 (2%)                    2 (4%)                                
   Islets, Pancreatic                                 (48)         (49)         (47)         (46)                                   
      Carcinoma                                                     1 (2%)                                                          
   Pituitary Gland                                    (47)         (48)         (48)         (48)                                   
      Pars Distalis, Adenoma                          10 (21%)      8 (17%)     14 (29%)      8 (17%)                               
      Pars Intermedia, Adenoma                                      1 (2%)       1 (2%)                                             
   Thyroid Gland                                      (50)         (50)         (49)         (47)                                   
      C-Cell, Adenoma                                  1 (2%)                                                                       
      C-Cell, Carcinoma                                                                       2 (4%)                                
      Follicular Cell, Adenoma                         2 (4%)       1 (2%)       3 (6%)       1 (2%)                                
      Follicular Cell, Carcinoma                       1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Ovary                                              (49)         (50)         (50)         (46)                                   
      Carcinoma                                                                  1 (2%)                                             
      Carcinoma, Metastatic, Islets, Pancreatic                     1 (2%)                                                          
      Cystadenoma                                                                2 (4%)       1 (2%)                                
      Histiocytic Sarcoma                              2 (4%)                                                                       
      Teratoma Benign                                                            1 (2%)                                             
   Uterus                                             (49)         (50)         (49)         (49)                                   
      Adenoma                                                                    1 (2%)                                             
      Carcinoma, Metastatic, Ovary                                               1 (2%)                                             
                                                             Page   3                                                               
NTP Experiment-Test: 05181-04  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                          TETRAHYDROFURAN                                      Date: 02/21/96  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 12:11:24  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE FEMALE                        CONTROL      200 PPM      600 PPM      1800 PPM                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
GENITAL SYSTEM - cont                                                                                                               
      Deciduoma Benign                                 1 (2%)                                                                       
      Hemangiosarcoma                                               1 (2%)                                                          
      Histiocytic Sarcoma                              1 (2%)                                                                       
      Polyp Stromal                                    1 (2%)       4 (8%)       2 (4%)       1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (49)         (50)         (49)         (46)                                   
      Hemangiosarcoma                                  1 (2%)                                                                       
      Histiocytic Sarcoma                              2 (4%)                                                                       
      Sarcoma                                                                                 1 (2%)                                
   Lymph Node                                         (5)          (4)          (4)          (2)                                    
      Renal, Histiocytic Sarcoma                       1 (20%)                                                                      
   Lymph Node, Bronchial                              (36)         (41)         (39)         (41)                                   
      Carcinoma, Metastatic, Islets, Pancreatic                     1 (2%)                                                          
      Fibrous Histiocytoma, Metastatic, Mesentery                                             1 (2%)                                
      Hepatocellular Carcinoma, Metastatic, Liver                   1 (2%)                                                          
      Histiocytic Sarcoma                              1 (3%)                                                                       
   Lymph Node, Mandibular                             (40)         (41)         (39)         (41)                                   
      Hemangioma                                       1 (3%)                                                                       
   Lymph Node, Mesenteric                             (45)         (46)         (47)         (45)                                   
      Carcinoma, Metastatic, Islets, Pancreatic                     1 (2%)                                                          
      Carcinoma, Metastatic, Ovary                                               1 (2%)                                             
      Histiocytic Sarcoma                              1 (2%)                    2 (4%)                                             
   Lymph Node, Mediastinal                            (37)         (36)         (41)         (38)                                   
      Carcinoma, Metastatic, Islets, Pancreatic                     1 (3%)                                                          
      Carcinoma, Metastatic, Ovary                                               1 (2%)                                             
      Fibrous Histiocytoma, Metastatic, Mesentery                                             1 (3%)                                
      Hepatocellular Carcinoma, Metastatic, Liver                   1 (3%)                                                          
      Hepatocholangiocarcinoma, Metastatic, Liver                   1 (3%)                                                          
   Spleen                                             (49)         (50)         (49)         (46)                                   
      Hemangiosarcoma                                  1 (2%)       1 (2%)       1 (2%)                                             
      Histiocytic Sarcoma                                                        1 (2%)                                             
   Thymus                                             (40)         (44)         (38)         (44)                                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Mammary Gland                                      (48)         (49)         (50)         (50)                                   
      Carcinoma                                                                  1 (2%)       1 (2%)                                
   Skin                                               (49)         (50)         (50)         (50)                                   
      Subcutaneous Tissue, Hemangioma                                            1 (2%)                                             
      Subcutaneous Tissue, Histiocytic Sarcoma         1 (2%)                                                                       
      Subcutaneous Tissue, Sarcoma                                               1 (2%)       3 (6%)                                
      Subcutaneous Tissue, Sarcoma, Metastatic,                                                                                     
           Mesentery                                   1 (2%)                                                                       
                                                             Page   4                                                               
NTP Experiment-Test: 05181-04  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                          TETRAHYDROFURAN                                      Date: 02/21/96  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 12:11:24  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE FEMALE                        CONTROL      200 PPM      600 PPM      1800 PPM                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Bone                                               (50)         (50)         (50)         (49)                                   
      Hemangiosarcoma                                  1 (2%)                                                                       
      Osteosarcoma                                     1 (2%)       1 (2%)                    2 (4%)                                
   Skeletal Muscle                                    (2)          (1)                                                              
      Carcinoma, Metastatic, Islets, Pancreatic                     1 (100%)                                                        
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (50)         (50)         (50)         (49)                                   
      Histiocytic Sarcoma                              2 (4%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (50)         (50)         (50)         (49)                                   
      Alveolar/Bronchiolar Adenoma                     1 (2%)       2 (4%)       3 (6%)       3 (6%)                                
      Alveolar/Bronchiolar Adenoma, Multiple                                     1 (2%)                                             
      Alveolar/Bronchiolar Carcinoma                   1 (2%)       1 (2%)       2 (4%)       2 (4%)                                
      Carcinoma, Metastatic, Ovary                                               1 (2%)                                             
      Hepatocellular Carcinoma, Metastatic, Liver      1 (2%)       5 (10%)      3 (6%)       3 (6%)                                
      Hepatocholangiocarcinoma, Metastatic, Liver      1 (2%)       1 (2%)                                                          
      Histiocytic Sarcoma                              3 (6%)                                                                       
      Osteosarcoma, Metastatic, Bone                                                          1 (2%)                                
      Sarcoma, Metastatic, Skin                                                  1 (2%)                                             
      Mediastinum, Fibrous Histiocytoma,                                                                                            
          Metastatic, Mesentery                                                               1 (2%)                                
      Mediastinum, Hemangiosarcoma                                               1 (2%)                                             
      Mediastinum, Hepatocholangiocarcinoma,                                                                                        
          Metastatic, Liver                                         1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Harderian Gland                                    (4)          (2)          (2)          (1)                                    
      Adenoma                                          2 (50%)      1 (50%)      2 (100%)     1 (100%)                              
      Carcinoma                                                     1 (50%)                                                         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                             Page   5                                                               
NTP Experiment-Test: 05181-04  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                          TETRAHYDROFURAN                                      Date: 02/21/96  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 12:11:24  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE FEMALE                        CONTROL      200 PPM      600 PPM      1800 PPM                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (50)         (49)         (49)         (46)                                   
      Carcinoma, Metastatic, Ovary                                               1 (2%)                                             
      Hepatocholangiocarcinoma, Metastatic, Liver                   1 (2%)                                                          
      Histiocytic Sarcoma                              3 (6%)                                                                       
   Urinary Bladder                                    (47)         (48)         (47)         (45)                                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SYSTEMIC LESIONS                                                                                                                   
   Multiple Organs                                   *(50)        *(50)        *(50)        *(50)                                   
      Histiocytic Sarcoma                              3 (6%)                    2 (4%)                                             
      Lymphoma Malignant                               7 (14%)      2 (4%)       4 (8%)       5 (10%)                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
     *   Number of animals with any tissue examined microscopically                                                                 
                                                             Page   6                                                               
NTP Experiment-Test: 05181-04  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                          TETRAHYDROFURAN                                      Date: 02/21/96  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 12:11:24  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE FEMALE                        CONTROL      200 PPM      600 PPM      1800 PPM                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
TUMOR SUMMARY                                                                                                                       
                                                                                                                                    
   Total Animals with Primary Neoplasms (b)            34          38          41          44                                       
     Total Primary Neoplasms                           58          59          74          83                                       
                                                                                                                                    
   Total Animals with Benign Neoplasms                 21          29          31          37                                       
     Total Benign Neoplasms                            32          38          49          48                                       
                                                                                                                                    
   Total Animals with Malignant Neoplasms              21          18          21          28                                       
     Total Malignant Neoplasms                         26          21          25          35                                       
                                                                                                                                    
   Total Animals with Metastatic Neoplasms              3           6           5           5                                       
     Total Metastatic Neoplasm                          4          20          12           9                                       
                                                                                                                                    
   Total Animals with Malignant Neoplasms                                                                                           
   Uncertain Primary Site                                                                                                           
                                                                                                                                    
   Total Animals with Neoplasms Uncertain-                                                                                          
   Benign or Malignant                                                                                                              
     Total Uncertain Neoplasms                                                                                                      
                                                                                                                                    
____________________________________________________________________________________________________________________________________
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Primary tumors: all tumors except metastatic tumors                                                                              
                                                             Page   7                                                               
NTP Experiment-Test: 05181-04  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                          TETRAHYDROFURAN                                      Date: 02/21/96  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 12:11:24  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE MALE                          CONTROL      200 PPM      600 PPM      1800 PPM                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
DISPOSITION SUMMARY                                                                                                                 
  Animals Initially in Study                          50           50           50           50                                     
  Early Deaths                                                                                                                      
    Natural Death                                      7            7            4           14                                     
    Moribund Sacrifice                                11           12           18           24                                     
  Survivors                                                                                                                         
    Terminal Sacrifice                                32           31           28           12                                     
  Animals Examined Microscopically                    50           50           50           50                                     
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Gallbladder                                        (42)         (46)         (44)         (38)                                   
      Cholangiocarcinoma, Metastatic, Liver                         1 (2%)                                                          
   Intestine Small, Jejunum                           (45)         (45)         (46)         (37)                                   
      Carcinoma                                        1 (2%)                    1 (2%)       1 (3%)                                
   Intestine Small, Ileum                             (46)         (46)         (46)         (40)                                   
   Liver                                              (50)         (50)         (50)         (50)                                   
      Cholangiocarcinoma                                            1 (2%)                                                          
      Hemangiosarcoma                                  1 (2%)       1 (2%)       2 (4%)                                             
      Hepatocellular Carcinoma                        10 (20%)      9 (18%)      8 (16%)      5 (10%)                               
      Hepatocellular Carcinoma, Multiple               4 (8%)       4 (8%)       6 (12%)      4 (8%)                                
      Hepatocellular Adenoma                          19 (38%)     14 (28%)     14 (28%)      9 (18%)                               
      Hepatocellular Adenoma, Multiple                 5 (10%)      5 (10%)      2 (4%)       5 (10%)                               
      Hepatocholangiocarcinoma                         3 (6%)                    1 (2%)                                             
      Histiocytic Sarcoma                                                        1 (2%)                                             
   Mesentery                                          (3)          (3)          (2)                                                 
      Cholangiocarcinoma, Metastatic, Liver                         1 (33%)                                                         
      Hemangioma                                                                 1 (50%)                                            
      Hemangiosarcoma                                               1 (33%)                                                         
      Hepatocholangiocarcinoma, Metastatic, Liver      1 (33%)                                                                      
   Pancreas                                           (48)         (48)         (46)         (48)                                   
      Hepatocholangiocarcinoma, Metastatic, Liver      1 (2%)                                                                       
   Salivary Glands                                    (50)         (50)         (50)         (50)                                   
   Tooth                                                           (1)          (2)                                                 
      Odontoma                                                                   1 (50%)                                            
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Heart                                              (49)         (50)         (50)         (50)                                   
      Cholangiocarcinoma, Metastatic, Liver                         1 (2%)                                                          
      Hemangiosarcoma                                               1 (2%)                                                          
      Hepatocholangiocarcinoma, Metastatic, Liver      1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                             Page   8                                                               
NTP Experiment-Test: 05181-04  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                          TETRAHYDROFURAN                                      Date: 02/21/96  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 12:11:24  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE MALE                          CONTROL      200 PPM      600 PPM      1800 PPM                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Cortex                                     (48)         (50)         (49)         (50)                                   
      Adenoma                                          3 (6%)       1 (2%)                                                          
   Adrenal Medulla                                    (48)         (50)         (49)         (50)                                   
      Pheochromocytoma Benign                          1 (2%)                    1 (2%)                                             
   Islets, Pancreatic                                 (48)         (48)         (46)         (48)                                   
      Adenoma                                                                                 1 (2%)                                
   Pituitary Gland                                    (45)         (47)         (45)         (47)                                   
      Pars Distalis, Adenoma                           1 (2%)                    1 (2%)                                             
   Thyroid Gland                                      (49)         (50)         (49)         (49)                                   
      Follicular Cell, Adenoma                         4 (8%)                    1 (2%)       1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Epididymis                                         (49)         (50)         (50)         (50)                                   
      Carcinoma, Metastatic, Lung                                                1 (2%)                                             
      Histiocytic Sarcoma                              1 (2%)                                                                       
      Sarcoma                                                       1 (2%)                                                          
   Preputial Gland                                    (50)         (49)         (50)         (48)                                   
   Prostate                                           (48)         (43)         (44)         (47)                                   
   Seminal Vesicle                                    (48)         (48)         (46)         (46)                                   
      Sarcoma                                          1 (2%)                                                                       
   Testes                                             (50)         (50)         (50)         (50)                                   
      Hemangioma                                       1 (2%)                                                                       
      Interstitial Cell, Adenoma                                    1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Lymph Node, Bronchial                              (33)         (32)         (36)         (26)                                   
      Carcinoma, Metastatic, Lung                                                1 (3%)                                             
      Cholangiocarcinoma, Metastatic, Liver                         1 (3%)                                                          
      Hepatocholangiocarcinoma, Metastatic, Liver      1 (3%)                                                                       
   Lymph Node, Mesenteric                             (47)         (48)         (46)         (41)                                   
      Cholangiocarcinoma, Metastatic, Liver                         1 (2%)                                                          
      Hepatocholangiocarcinoma, Metastatic, Liver      1 (2%)                                                                       
      Histiocytic Sarcoma                                                        1 (2%)                                             
   Lymph Node, Mediastinal                            (36)         (40)         (39)         (32)                                   
      Cholangiocarcinoma, Metastatic, Liver                         1 (3%)                                                          
      Hepatocholangiocarcinoma, Metastatic, Liver      2 (6%)                                                                       
                                                             Page   9                                                               
NTP Experiment-Test: 05181-04  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                          TETRAHYDROFURAN                                      Date: 02/21/96  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 12:11:24  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE MALE                          CONTROL      200 PPM      600 PPM      1800 PPM                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
HEMATOPOIETIC SYSTEM - cont                                                                                                         
   Spleen                                             (48)         (49)         (47)         (49)                                   
      Hemangiosarcoma                                                            1 (2%)                                             
   Thymus                                             (35)         (37)         (34)         (36)                                   
      Cholangiocarcinoma, Metastatic, Liver                         1 (3%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Skin                                               (47)         (50)         (48)         (50)                                   
      Prepuce, Sarcoma                                              1 (2%)                                                          
      Subcutaneous Tissue, Hemangiosarcoma                                                    1 (2%)                                
      Subcutaneous Tissue, Sarcoma, Metastatic,                                                                                     
           Epididymis                                               1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Bone                                               (50)         (50)         (50)         (50)                                   
      Hepatocholangiocarcinoma, Metastatic, Liver      1 (2%)                                                                       
   Skeletal Muscle                                    (2)          (1)                                                              
      Cholangiocarcinoma, Metastatic, Liver                         1 (100%)                                                        
      Hepatocholangiocarcinoma, Metastatic, Liver      2 (100%)                                                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Larynx                                             (48)         (49)         (48)         (48)                                   
   Lung                                               (50)         (50)         (50)         (50)                                   
      Alveolar/Bronchiolar Adenoma                    16 (32%)      6 (12%)      7 (14%)      4 (8%)                                
      Alveolar/Bronchiolar Adenoma, Multiple           2 (4%)       1 (2%)       1 (2%)                                             
      Alveolar/Bronchiolar Carcinoma                   6 (12%)      9 (18%)      6 (12%)      3 (6%)                                
      Carcinoma                                                                  1 (2%)                                             
      Carcinoma, Metastatic, Harderian Gland           1 (2%)                                                                       
      Cholangiocarcinoma, Metastatic, Liver                         1 (2%)                                                          
      Hemangiosarcoma, Metastatic, Skin                                                       1 (2%)                                
      Hepatocellular Carcinoma, Metastatic, Liver      1 (2%)       1 (2%)       3 (6%)                                             
      Hepatocholangiocarcinoma, Metastatic, Liver      2 (4%)                    1 (2%)                                             
      Mediastinum, Hemangiosarcoma                                  1 (2%)                                                          
      Mediastinum, Hepatocholangiocarcinoma,                                                                                        
          Metastatic, Liver                            2 (4%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                             Page  10                                                               
NTP Experiment-Test: 05181-04  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                          TETRAHYDROFURAN                                      Date: 02/21/96  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 12:11:24  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE MALE                          CONTROL      200 PPM      600 PPM      1800 PPM                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Harderian Gland                                    (4)          (4)          (4)          (3)                                    
      Adenoma                                          1 (25%)      3 (75%)      3 (75%)      1 (33%)                               
      Carcinoma                                        3 (75%)                                1 (33%)                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (49)         (50)         (49)         (50)                                   
      Cholangiocarcinoma, Metastatic, Liver                         1 (2%)                                                          
      Hepatocholangiocarcinoma, Metastatic, Liver      1 (2%)                                                                       
      Renal Tubule, Adenoma                            1 (2%)                                                                       
   Urinary Bladder                                    (48)         (49)         (46)         (48)                                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SYSTEMIC LESIONS                                                                                                                   
   Multiple Organs                                   *(50)        *(50)        *(50)        *(50)                                   
      Histiocytic Sarcoma                              1 (2%)                    1 (2%)                                             
      Lymphoma Malignant                               2 (4%)       1 (2%)       2 (4%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
     *   Number of animals with any tissue examined microscopically                                                                 
                                                             Page  11                                                               
NTP Experiment-Test: 05181-04  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                          TETRAHYDROFURAN                                      Date: 02/21/96  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 12:11:24  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE MALE                          CONTROL      200 PPM      600 PPM      1800 PPM                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
TUMOR SUMMARY                                                                                                                       
                                                                                                                                    
   Total Animals with Primary Neoplasms (b)            47          39          44          21                                       
     Total Primary Neoplasms                           86          61          61          36                                       
                                                                                                                                    
   Total Animals with Benign Neoplasms                 36          27          26          17                                       
     Total Benign Neoplasms                            54          31          32          21                                       
                                                                                                                                    
   Total Animals with Malignant Neoplasms              24          25          26          12                                       
     Total Malignant Neoplasms                         32          30          29          15                                       
                                                                                                                                    
   Total Animals with Metastatic Neoplasms              4           3           5           1                                       
     Total Metastatic Neoplasm                         17          12           6           1                                       
                                                                                                                                    
   Total Animals with Malignant Neoplasms                                                                                           
   Uncertain Primary Site                                                                                                           
                                                                                                                                    
   Total Animals with Neoplasms Uncertain-                                                                                          
   Benign or Malignant                                                                                                              
     Total Uncertain Neoplasms                                                                                                      
                                                                                                                                    
____________________________________________________________________________________________________________________________________
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Primary tumors: all tumors except metastatic tumors                                                                              
                                                             Page  12                                                               
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