TDMS Study 05181-04 Pathology Tables
NTP STATISTICAL ANALYSIS OF SURVIVAL DATA REPORT: PEIRPT11
LAB: Battelle Northwest TETRAHYDROFURAN DATE: 02/21/96
EXPERIMENT: 05181 TEST: 04 TIME: 13:23:02
TEST TYPE: CHRONIC CAGES FROM 0000 TO LAST CAGE PAGE: 1
CONT: N01-ES-95259 ROUTE: RESPIRATORY EXPOSURE WHOLE BODY NTP C#: 60560C
PATHOLOGIST: R. MILLER CAS: 0109-99-9
------------------------------------------------------------------------------------------------------------------------------------
CORE STUDY
REASONS FOR REMOVAL: ALL
REMOVAL DATE RANGE: ALL
TREATMENT GROUPS: INCLUDE ALL
NTP STATISTICAL ANALYSIS OF SURVIVAL DATA REPORT: PEIRPT11
LAB: Battelle Northwest TETRAHYDROFURAN DATE: 02/21/96
EXPERIMENT: 05181 TEST: 04 TIME: 13:23:02
TEST TYPE: CHRONIC CAGES FROM 0000 TO LAST CAGE
CONT: N01-ES-95259 ROUTE: RESPIRATORY EXPOSURE WHOLE BODY NTP C#: 60560C
PATHOLOGIST: R. MILLER CAS: 0109-99-9
TETRAHYDROFURAN
STATISTICAL ANALYSIS OF SURVIVAL DATA
MALE MICE
FIRST TERMINAL SACRIFICE AT 733 DAYS
INDIVIDUAL SURVIVAL TIMES (DAYS)
==================================================================================
| DOSE = CONTROL |
| --------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 18 CENSORED DEATHS 0 TERMINAL 32 |
| |
| UNCENSORED DEATHS |
| 362 440 481 544 557 582 582 638 638 644 |
| 658 670 675 678 690 699 719 721 |
| CENSORED DEATHS |
| NONE |
| |
|--------------------------------------------------------------------------------|
| DOSE = 200 PPM |
| --------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 19 CENSORED DEATHS 0 TERMINAL 31 |
| |
| UNCENSORED DEATHS |
| 314 324 441 475 526 532 544 554 554 574 |
| 577 638 644 646 666 685 694 706 713 |
| CENSORED DEATHS |
| NONE |
| |
|--------------------------------------------------------------------------------|
| DOSE = 600 PPM |
| --------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 22 CENSORED DEATHS 0 TERMINAL 28 |
| |
| UNCENSORED DEATHS |
| 376 440 504 512 551 554 558 560 569 574 |
| 574 582 594 594 595 604 631 644 658 666 |
| 694 721 |
| CENSORED DEATHS |
| NONE |
| |
==================================================================================
TETRAHYDROFURAN
STATISTICAL ANALYSIS OF SURVIVAL DATA
MALE MICE
FIRST TERMINAL SACRIFICE AT 733 DAYS
INDIVIDUAL SURVIVAL TIMES (DAYS)
==================================================================================
| DOSE = 1800 PPM |
| --------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 38 CENSORED DEATHS 0 TERMINAL 12 |
| |
| UNCENSORED DEATHS |
| 7 99 102 189 190 191 229 239 240 245 |
| 260 265 273 275 275 313 321 335 346 349 |
| 359 359 359 359 359 359 386 414 452 527 |
| 554 639 658 670 687 706 715 721 |
| CENSORED DEATHS |
| NONE |
| |
==================================================================================
TETRAHYDROFURAN
STATISTICAL ANALYSIS OF SURVIVAL DATA
MALE MICE
FIRST TERMINAL SACRIFICE AT 733 DAYS
==================================================================================
| KAPLAN-MEIER SURVIVAL PROBABILITY ESTIMATES (%) |
| |
|--------------------------------------------------------------------------------|
| DOSE TIME (DAYS) |
| 90 180 270 365 425 485 545 605 665 733 (A) |
| |
|--------------------------------------------------------------------------------|
| | |
|CONTROL | 100.0 100.0 100.0 98.0 98.0 94.0 92.0 86.0 78.0 64.0 |
| | |
| | |
|200 PPM | 100.0 100.0 100.0 96.0 96.0 92.0 86.0 78.0 72.0 62.0 |
| | |
| | |
|600 PPM | 100.0 100.0 100.0 100.0 98.0 96.0 92.0 68.0 62.0 56.0 |
| | |
| | |
|1800 PPM | 98.0 94.0 76.0 48.0 44.0 42.0 40.0 38.0 34.0 24.0 |
| | |
| | |
==================================================================================
==================================================================================
| SURVIVAL SUMMARY STATISTICS |
| |
| |
|--------------------------------------------------------------------------------|
| DOSE |
| |
| CONTROL 200 PPM 600 PPM 1800 PPM |
| |
|--------------------------------------------------------------------------------|
|SURVIVAL AT END OF STUDY| 64.0% 62.0% 56.0% 24.0% |
|(KAPLAN-MEIER) | |
| | |
|SIGNIFICANCE (B) | P<0.001 P=0.839 P=0.384 P<0.001 |
|(LIFE TABLE) | |
| | |
|MEAN DAY OF | 609.9 568.8 579.8 369.1 |
|NATURAL DEATHS (C) | (23.7) (27.0) (16.7) (30.1) |
|(STANDARD ERROR) | |
| | |
|MEAN LIFE SPAN (D) | 688.7 670.6 665.6 456.4 |
|(STANDARD ERROR) | (11.9) (15.2) (13.1) (31.8) |
| | |
==================================================================================
(A) FIRST TERMINAL SACRIFICE
(B) THE FIRST ENTRY IS THE TREND TEST (TARONE, 1975) RESULT.
SUBSEQUENT ENTRIES ARE THE RESULTS OF PAIRWISE TESTS
(COX,1972). NEGATIVE TRENDS ARE INDICATED BY "N".
(C) MEAN OF ALL UNCENSORED DEATHS PRIOR TO TERMINAL SACRIFICE
(D) MEAN OF ALL DEATHS (UNCENSORED, CENSORED, TERMINAL SACRIFICE)
TETRAHYDROFURAN
STATISTICAL ANALYSIS OF SURVIVAL DATA
FEMALE MICE
FIRST TERMINAL SACRIFICE AT 733 DAYS
INDIVIDUAL SURVIVAL TIMES (DAYS)
==================================================================================
| DOSE = CONTROL |
| --------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 16 CENSORED DEATHS 5 TERMINAL 29 |
| |
| UNCENSORED DEATHS |
| 442 442 478 495 502 572 574 599 604 630 |
| 648 651 652 680 706 708 |
| CENSORED DEATHS |
| 19 19 19 19 19 |
| |
|--------------------------------------------------------------------------------|
| DOSE = 200 PPM |
| --------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 16 CENSORED DEATHS 1 TERMINAL 33 |
| |
| UNCENSORED DEATHS |
| 134 460 504 525 526 552 582 601 609 630 |
| 635 640 652 680 690 698 |
| CENSORED DEATHS |
| 273 |
| |
|--------------------------------------------------------------------------------|
| DOSE = 600 PPM |
| --------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 23 CENSORED DEATHS 1 TERMINAL 26 |
| |
| UNCENSORED DEATHS |
| 429 460 469 536 544 555 566 574 594 599 |
| 610 631 639 670 674 680 690 706 706 708 |
| 715 720 721 |
| CENSORED DEATHS |
| 2 |
| |
==================================================================================
TETRAHYDROFURAN
STATISTICAL ANALYSIS OF SURVIVAL DATA
FEMALE MICE
FIRST TERMINAL SACRIFICE AT 733 DAYS
INDIVIDUAL SURVIVAL TIMES (DAYS)
==================================================================================
| DOSE = 1800 PPM |
| --------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 18 CENSORED DEATHS 0 TERMINAL 32 |
| |
| UNCENSORED DEATHS |
| 399 403 527 558 562 566 574 577 582 598 |
| 599 604 610 628 631 645 664 702 |
| CENSORED DEATHS |
| NONE |
| |
==================================================================================
TETRAHYDROFURAN
STATISTICAL ANALYSIS OF SURVIVAL DATA
FEMALE MICE
FIRST TERMINAL SACRIFICE AT 733 DAYS
==================================================================================
| KAPLAN-MEIER SURVIVAL PROBABILITY ESTIMATES (%) |
| |
|--------------------------------------------------------------------------------|
| DOSE TIME (DAYS) |
| 90 180 270 365 425 485 545 605 665 733 (A) |
| |
|--------------------------------------------------------------------------------|
| | |
|CONTROL | 100.0 100.0 100.0 100.0 100.0 93.3 88.9 80.0 71.1 64.4 |
| | |
| | |
|200 PPM | 100.0 98.0 98.0 98.0 98.0 96.0 89.8 83.7 73.5 67.4 |
| | |
| | |
|600 PPM | 100.0 100.0 100.0 100.0 100.0 93.9 89.8 79.6 73.5 53.1 |
| | |
| | |
|1800 PPM | 100.0 100.0 100.0 100.0 96.0 96.0 94.0 76.0 66.0 64.0 |
| | |
| | |
==================================================================================
==================================================================================
| SURVIVAL SUMMARY STATISTICS |
| |
| |
|--------------------------------------------------------------------------------|
| DOSE |
| |
| CONTROL 200 PPM 600 PPM 1800 PPM |
| |
|--------------------------------------------------------------------------------|
|SURVIVAL AT END OF STUDY| 64.4% 67.4% 53.1% 64.0% |
|(KAPLAN-MEIER) | |
| | |
|SIGNIFICANCE (B) | P=0.917 P=0.907N P=0.439 P=1.000 |
|(LIFE TABLE) | |
| | |
|MEAN DAY OF | 586.4 569.9 617.2 579.4 |
|NATURAL DEATHS (C) | (22.5) (33.9) (18.6) (18.2) |
|(STANDARD ERROR) | |
| | |
|MEAN LIFE SPAN (D) | 614.7 671.6 665.1 677.7 |
|(STANDARD ERROR) | (30.7) (17.2) (17.9) (12.3) |
| | |
==================================================================================
(A) FIRST TERMINAL SACRIFICE
(B) THE FIRST ENTRY IS THE TREND TEST (TARONE, 1975) RESULT.
SUBSEQUENT ENTRIES ARE THE RESULTS OF PAIRWISE TESTS
(COX,1972). NEGATIVE TRENDS ARE INDICATED BY "N".
(C) MEAN OF ALL UNCENSORED DEATHS PRIOR TO TERMINAL SACRIFICE
(D) MEAN OF ALL DEATHS (UNCENSORED, CENSORED, TERMINAL SACRIFICE)
TETRAHYDROFURAN
KAPLAN-MEIER SURVIVAL CURVES
CONTROL = 1
200 PPM = 2
600 PPM = 3
1800 PPM = 4
------------------------------------------------------ SPECIES=MICE SEX=MALE -------------------------------------------------------
Plot of SURVIVAL*WEEK. Symbol is value of DOSE.
|
|
100 + 14 2 1 3
| 4 4 2 2 1 3 1
| 4 4 2 1 21 3 3 1
| 44 2 3 2 131
90 + 31 1
| 4 4 2 2
| 4 4 2 2 3 1 1
| 2 2
P 80 + 4 4 22 1 1
E | 323 2 1 1
R | 444 3 3 22 11
C | 2 21 1
E 70 + 4 4 3 3 2 211
N | 44 3 3 2 1 1
T | 4 4 4 33 3 2221 1
| 3 3 2 2
S 60 + 4 4 3 3
U | 3 3
R | 3 3
V |
I 50 +
V | 4 4
A | 4 4 4
L | 4 4
40 + 4 4
| 4 4
| 4 4 4
| 4 4
30 + 4 4
| 4 4
| 4 4
|
20 +
|
--+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+--
0 10 20 30 40 50 60 70 80 90 100 110
WEEK
NOTE: 18 obs hidden.
TETRAHYDROFURAN
KAPLAN-MEIER SURVIVAL CURVES
CONTROL = 1
200 PPM = 2
600 PPM = 3
1800 PPM = 4
----------------------------------------------------- SPECIES=MICE SEX=FEMALE ------------------------------------------------------
Plot of SURVIVAL*WEEK. Symbol is value of DOSE.
|
100 + 1 2 4 3 1
|
| 2 44 3 2
| 4 23 2 4
95 + 1 1
| 3 1 12 243 4
| 22 44
| 11 33
90 + 2 323
| 1 1
| 2334 2
| 3342 2
P 85 + 1 1
E | 344 322
R | 4 11
C | 332 2
E 80 + 313 12
N |
T | 443 1221
| 44
S 75 + 32 2
U | 4 4 311 3 2
R | 44
V | 1 3312
I 70 + 4 4 3322
V | 1 1
A | 4 4 332 2
L | 4 11
65 + 3 31 1
| 4 4
|
| 33
60 +
| 33
|
|
55 +
|
| 3 3
|
50 +
|
--+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+--
0 10 20 30 40 50 60 70 80 90 100 110
WEEK
NOTE: 14 obs hidden.