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TDMS Study 05181-04 Pathology Tables

NTP                                         STATISTICAL ANALYSIS OF SURVIVAL DATA                              REPORT: PEIRPT11     
LAB: Battelle Northwest                                     TETRAHYDROFURAN                                    DATE: 02/21/96       
EXPERIMENT: 05181 TEST: 04                                                                                     TIME: 13:23:02       
TEST TYPE:  CHRONIC                             CAGES FROM 0000 TO LAST CAGE                                   PAGE:       1        
CONT: N01-ES-95259                              ROUTE: RESPIRATORY EXPOSURE WHOLE BODY                         NTP C#: 60560C       
PATHOLOGIST: R. MILLER                                                                                         CAS: 0109-99-9       
------------------------------------------------------------------------------------------------------------------------------------
                                                                                                                                    
                                                             CORE STUDY                                                             
                                                                                                                                    

               REASONS FOR REMOVAL:    ALL                                                                                          
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
               REMOVAL DATE RANGE:     ALL                                                                                          
                                                                                                                                    
               TREATMENT GROUPS:       INCLUDE ALL                                                                                  
NTP                                         STATISTICAL ANALYSIS OF SURVIVAL DATA                              REPORT: PEIRPT11    
LAB: Battelle Northwest                                     TETRAHYDROFURAN                                    DATE: 02/21/96      
EXPERIMENT: 05181 TEST: 04                                                                                     TIME: 13:23:02      
TEST TYPE:  CHRONIC                             CAGES FROM 0000 TO LAST CAGE                                                       
CONT: N01-ES-95259                              ROUTE: RESPIRATORY EXPOSURE WHOLE BODY                         NTP C#: 60560C      
PATHOLOGIST: R. MILLER                                                                                         CAS: 0109-99-9      
                                  TETRAHYDROFURAN

                       STATISTICAL ANALYSIS OF SURVIVAL DATA
                                     MALE MICE
                       FIRST TERMINAL SACRIFICE AT 733 DAYS
                                                          

                          INDIVIDUAL SURVIVAL TIMES (DAYS)
 ==================================================================================
 |                                DOSE = CONTROL                                  |
 |                             ---------------------                              |
 |                                                                                |
 |  TOTAL 50     UNCENSORED DEATHS 18     CENSORED DEATHS 0    TERMINAL 32        |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      362   440   481   544   557   582   582   638   638   644                 |
 |      658   670   675   678   690   699   719   721                             |
 |  CENSORED DEATHS                                                               |
 |      NONE                                                                      |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |                                DOSE = 200 PPM                                  |
 |                             ---------------------                              |
 |                                                                                |
 |  TOTAL 50     UNCENSORED DEATHS 19     CENSORED DEATHS 0    TERMINAL 31        |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      314   324   441   475   526   532   544   554   554   574                 |
 |      577   638   644   646   666   685   694   706   713                       |
 |  CENSORED DEATHS                                                               |
 |      NONE                                                                      |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |                                DOSE = 600 PPM                                  |
 |                             ---------------------                              |
 |                                                                                |
 |  TOTAL 50     UNCENSORED DEATHS 22     CENSORED DEATHS 0    TERMINAL 28        |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      376   440   504   512   551   554   558   560   569   574                 |
 |      574   582   594   594   595   604   631   644   658   666                 |
 |      694   721                                                                 |
 |  CENSORED DEATHS                                                               |
 |      NONE                                                                      |
 |                                                                                |
 ==================================================================================
                                  TETRAHYDROFURAN

                       STATISTICAL ANALYSIS OF SURVIVAL DATA
                                     MALE MICE
                       FIRST TERMINAL SACRIFICE AT 733 DAYS
                                                          

                          INDIVIDUAL SURVIVAL TIMES (DAYS)
 ==================================================================================
 |                                DOSE = 1800 PPM                                 |
 |                             ---------------------                              |
 |                                                                                |
 |  TOTAL 50     UNCENSORED DEATHS 38     CENSORED DEATHS 0    TERMINAL 12        |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      7     99    102   189   190   191   229   239   240   245                 |
 |      260   265   273   275   275   313   321   335   346   349                 |
 |      359   359   359   359   359   359   386   414   452   527                 |
 |      554   639   658   670   687   706   715   721                             |
 |  CENSORED DEATHS                                                               |
 |      NONE                                                                      |
 |                                                                                |
 ==================================================================================
                                  TETRAHYDROFURAN

                       STATISTICAL ANALYSIS OF SURVIVAL DATA
                                     MALE MICE
                       FIRST TERMINAL SACRIFICE AT 733 DAYS

 ==================================================================================
 |               KAPLAN-MEIER SURVIVAL PROBABILITY ESTIMATES (%)                  |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |    DOSE                               TIME (DAYS)                              |
 |                 90   180   270   365   425   485   545   605   665   733 (A)   |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |           |                                                                    |
 |CONTROL    |   100.0 100.0 100.0  98.0  98.0  94.0  92.0  86.0  78.0  64.0      |
 |           |                                                                    |
 |           |                                                                    |
 |200 PPM    |   100.0 100.0 100.0  96.0  96.0  92.0  86.0  78.0  72.0  62.0      |
 |           |                                                                    |
 |           |                                                                    |
 |600 PPM    |   100.0 100.0 100.0 100.0  98.0  96.0  92.0  68.0  62.0  56.0      |
 |           |                                                                    |
 |           |                                                                    |
 |1800 PPM   |    98.0  94.0  76.0  48.0  44.0  42.0  40.0  38.0  34.0  24.0      |
 |           |                                                                    |
 |           |                                                                    |
 ==================================================================================
 ==================================================================================
 |                           SURVIVAL SUMMARY STATISTICS                          |
 |                                                                                |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |                                                  DOSE                          |
 |                                                                                |
 |                                CONTROL      200 PPM      600 PPM      1800 PPM |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |SURVIVAL AT END OF STUDY|       64.0%        62.0%        56.0%        24.0%    |
 |(KAPLAN-MEIER)          |                                                       |
 |                        |                                                       |
 |SIGNIFICANCE (B)        |       P<0.001      P=0.839      P=0.384      P<0.001  |
 |(LIFE TABLE)            |                                                       |
 |                        |                                                       |
 |MEAN DAY OF             |       609.9        568.8        579.8        369.1    |
 |NATURAL DEATHS (C)      |       (23.7)       (27.0)       (16.7)       (30.1)   |
 |(STANDARD ERROR)        |                                                       |
 |                        |                                                       |
 |MEAN LIFE SPAN (D)      |       688.7        670.6        665.6        456.4    |
 |(STANDARD ERROR)        |       (11.9)       (15.2)       (13.1)       (31.8)   |
 |                        |                                                       |
 ==================================================================================
                                    

       (A)  FIRST TERMINAL SACRIFICE
       (B)  THE FIRST ENTRY IS THE TREND TEST (TARONE, 1975) RESULT.
            SUBSEQUENT ENTRIES ARE THE RESULTS OF PAIRWISE TESTS
            (COX,1972).  NEGATIVE TRENDS ARE INDICATED BY "N".
       (C)  MEAN OF ALL UNCENSORED DEATHS PRIOR TO TERMINAL SACRIFICE
       (D)  MEAN OF ALL DEATHS (UNCENSORED, CENSORED, TERMINAL SACRIFICE)
                                  TETRAHYDROFURAN

                       STATISTICAL ANALYSIS OF SURVIVAL DATA
                                    FEMALE MICE
                       FIRST TERMINAL SACRIFICE AT 733 DAYS
                                                          

                          INDIVIDUAL SURVIVAL TIMES (DAYS)
 ==================================================================================
 |                                DOSE = CONTROL                                  |
 |                             ---------------------                              |
 |                                                                                |
 |  TOTAL 50     UNCENSORED DEATHS 16     CENSORED DEATHS 5    TERMINAL 29        |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      442   442   478   495   502   572   574   599   604   630                 |
 |      648   651   652   680   706   708                                         |
 |  CENSORED DEATHS                                                               |
 |      19    19    19    19    19                                                |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |                                DOSE = 200 PPM                                  |
 |                             ---------------------                              |
 |                                                                                |
 |  TOTAL 50     UNCENSORED DEATHS 16     CENSORED DEATHS 1    TERMINAL 33        |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      134   460   504   525   526   552   582   601   609   630                 |
 |      635   640   652   680   690   698                                         |
 |  CENSORED DEATHS                                                               |
 |      273                                                                       |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |                                DOSE = 600 PPM                                  |
 |                             ---------------------                              |
 |                                                                                |
 |  TOTAL 50     UNCENSORED DEATHS 23     CENSORED DEATHS 1    TERMINAL 26        |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      429   460   469   536   544   555   566   574   594   599                 |
 |      610   631   639   670   674   680   690   706   706   708                 |
 |      715   720   721                                                           |
 |  CENSORED DEATHS                                                               |
 |      2                                                                         |
 |                                                                                |
 ==================================================================================
                                  TETRAHYDROFURAN

                       STATISTICAL ANALYSIS OF SURVIVAL DATA
                                    FEMALE MICE
                       FIRST TERMINAL SACRIFICE AT 733 DAYS
                                                          

                          INDIVIDUAL SURVIVAL TIMES (DAYS)
 ==================================================================================
 |                                DOSE = 1800 PPM                                 |
 |                             ---------------------                              |
 |                                                                                |
 |  TOTAL 50     UNCENSORED DEATHS 18     CENSORED DEATHS 0    TERMINAL 32        |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      399   403   527   558   562   566   574   577   582   598                 |
 |      599   604   610   628   631   645   664   702                             |
 |  CENSORED DEATHS                                                               |
 |      NONE                                                                      |
 |                                                                                |
 ==================================================================================
                                  TETRAHYDROFURAN

                       STATISTICAL ANALYSIS OF SURVIVAL DATA
                                    FEMALE MICE
                       FIRST TERMINAL SACRIFICE AT 733 DAYS

 ==================================================================================
 |               KAPLAN-MEIER SURVIVAL PROBABILITY ESTIMATES (%)                  |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |    DOSE                               TIME (DAYS)                              |
 |                 90   180   270   365   425   485   545   605   665   733 (A)   |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |           |                                                                    |
 |CONTROL    |   100.0 100.0 100.0 100.0 100.0  93.3  88.9  80.0  71.1  64.4      |
 |           |                                                                    |
 |           |                                                                    |
 |200 PPM    |   100.0  98.0  98.0  98.0  98.0  96.0  89.8  83.7  73.5  67.4      |
 |           |                                                                    |
 |           |                                                                    |
 |600 PPM    |   100.0 100.0 100.0 100.0 100.0  93.9  89.8  79.6  73.5  53.1      |
 |           |                                                                    |
 |           |                                                                    |
 |1800 PPM   |   100.0 100.0 100.0 100.0  96.0  96.0  94.0  76.0  66.0  64.0      |
 |           |                                                                    |
 |           |                                                                    |
 ==================================================================================
 ==================================================================================
 |                           SURVIVAL SUMMARY STATISTICS                          |
 |                                                                                |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |                                                  DOSE                          |
 |                                                                                |
 |                                CONTROL      200 PPM      600 PPM      1800 PPM |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |SURVIVAL AT END OF STUDY|       64.4%        67.4%        53.1%        64.0%    |
 |(KAPLAN-MEIER)          |                                                       |
 |                        |                                                       |
 |SIGNIFICANCE (B)        |       P=0.917      P=0.907N     P=0.439      P=1.000  |
 |(LIFE TABLE)            |                                                       |
 |                        |                                                       |
 |MEAN DAY OF             |       586.4        569.9        617.2        579.4    |
 |NATURAL DEATHS (C)      |       (22.5)       (33.9)       (18.6)       (18.2)   |
 |(STANDARD ERROR)        |                                                       |
 |                        |                                                       |
 |MEAN LIFE SPAN (D)      |       614.7        671.6        665.1        677.7    |
 |(STANDARD ERROR)        |       (30.7)       (17.2)       (17.9)       (12.3)   |
 |                        |                                                       |
 ==================================================================================
                                    

       (A)  FIRST TERMINAL SACRIFICE
       (B)  THE FIRST ENTRY IS THE TREND TEST (TARONE, 1975) RESULT.
            SUBSEQUENT ENTRIES ARE THE RESULTS OF PAIRWISE TESTS
            (COX,1972).  NEGATIVE TRENDS ARE INDICATED BY "N".
       (C)  MEAN OF ALL UNCENSORED DEATHS PRIOR TO TERMINAL SACRIFICE
       (D)  MEAN OF ALL DEATHS (UNCENSORED, CENSORED, TERMINAL SACRIFICE)
                                                          TETRAHYDROFURAN
                                                    KAPLAN-MEIER SURVIVAL CURVES
                                                        CONTROL          = 1
                                                        200 PPM          = 2
                                                        600 PPM          = 3
                                                        1800 PPM         = 4

------------------------------------------------------ SPECIES=MICE SEX=MALE -------------------------------------------------------

                                         Plot of SURVIVAL*WEEK.  Symbol is value of DOSE.

      |
      |
  100 + 14                                                2      1 3
      |  4               4                                2 2    1 3         1
      |                  4            4                     2                1     21  3 3    1
      |                               44                                           2     3  2 131
   90 +                                                                                        31   1
      |                                4    4                                               2 2
      |                                     4  4                                              2 2 3 1        1
      |                                                                                         2 2
P  80 +                                        4  4                                               22         1 1
E     |                                                                                           323        2 1  1
R     |                                           444                                               3 3      22   11
C     |                                                                                                       2   21 1
E  70 +                                             4     4                                           3 3         2 211
N     |                                                   44                                            3   3       2 1  1
T     |                                                    4 4 4                                            33 3      2221  1
      |                                                                                                        3  3     2   2
S  60 +                                                        4 4                                                3   3
U     |                                                                                                               3  3
R     |                                                                                                                  3  3
V     |
I  50 +
V     |                                                          4    4
A     |                                                               4   4     4
L     |                                                                         4           4
   40 +                                                                                     4   4
      |                                                                                         4            4
      |                                                                                                      4 4  4
      |                                                                                                           4  4
   30 +                                                                                                              4 4
      |                                                                                                                4 4
      |                                                                                                                  4  4
      |
   20 +
      |
      --+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+--
        0         10         20         30         40         50         60         70         80         90         100        110

                                                                   WEEK

NOTE: 18 obs hidden.
                                                          TETRAHYDROFURAN
                                                    KAPLAN-MEIER SURVIVAL CURVES
                                                        CONTROL          = 1
                                                        200 PPM          = 2
                                                        600 PPM          = 3
                                                        1800 PPM         = 4

----------------------------------------------------- SPECIES=MICE SEX=FEMALE ------------------------------------------------------

                                         Plot of SURVIVAL*WEEK.  Symbol is value of DOSE.

      |
  100 + 1                     2                                        4    3 1
      |
      |                       2                                        44   3    2
      |                                                                 4        23    2    4
   95 +                                                                       1     1
      |                                                                           3 1 12   243  4
      |                                                                                    22   44
      |                                                                               11     33
   90 +                                                                                     2 323
      |                                                                                1          1
      |                                                                                        2334 2
      |                                                                                          3342  2
P  85 +                                                                                           1    1
E     |                                                                                           344 322
R     |                                                                                             4  11
C     |                                                                                               332  2
E  80 +                                                                                                313 12
N     |
T     |                                                                                                443 1221
      |                                                                                                 44
S  75 +                                                                                                     32 2
U     |                                                                                                  4 4 311  3 2
R     |                                                                                                    44
V     |                                                                                                        1  3312
I  70 +                                                                                                     4 4    3322
V     |                                                                                                             1  1
A     |                                                                                                       4  4  332     2
L     |                                                                                                          4     11
   65 +                                                                                                              3 31   1
      |                                                                                                                4    4
      |
      |                                                                                                                33
   60 +
      |                                                                                                                 33
      |
      |
   55 +
      |
      |                                                                                                                  3  3
      |
   50 +
      |
      --+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+--
        0         10         20         30         40         50         60         70         80         90         100        110

                                                                   WEEK

NOTE: 14 obs hidden.