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TDMS Study 05181-03 Pathology Tables

NTP                                        STATISTICAL ANALYSIS OF PRIMARY TUMORS                              REPORT: PEIRPT08     
LAB: Battelle Northwest                                     TETRAHYDROFURAN                                    DATE: 02/20/96       
EXPERIMENT: 05181 TEST: 03                                                                                     TIME: 16:11:01       
TEST TYPE:  CHRONIC                             CAGES FROM 0000 TO LAST CAGE                                   PAGE:       1        
CONT: N01-ES-95259                              ROUTE: RESPIRATORY EXPOSURE WHOLE BODY                         NTP C#: 60560C       
PATHOLOGIST: R. RENNE                                                                                          CAS: 0109-99-9       
------------------------------------------------------------------------------------------------------------------------------------
                                                                                                                                    
                                                             CORE STUDY                                                             
                                                                                                                                    
               REASONS FOR REMOVAL:    ALL                                                                                          
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
               REMOVAL DATE RANGE:     ALL                                                                                          
                                                                                                                                    
               TREATMENT GROUPS:       INCLUDE ALL                                                                                  
NTP                                        STATISTICAL ANALYSIS OF PRIMARY TUMORS                              REPORT: PEIRPT08     
LAB: Battelle Northwest                                     TETRAHYDROFURAN                                    DATE: 02/20/96       
EXPERIMENT: 05181 TEST: 03                                                                                     TIME: 16:11:01       
TEST TYPE:  CHRONIC                             CAGES FROM 0000 TO LAST CAGE                                                        
CONT: N01-ES-95259                              ROUTE: RESPIRATORY EXPOSURE WHOLE BODY                         NTP C#: 60560C       
PATHOLOGIST: R. RENNE                                                                                          CAS: 0109-99-9       


                                                    RATS(FISCHER344)
                                              ----------------------------
             FOR ALL DOSES THE TUMOR RATES IN THE FOLLOWING TISSUES/ORGANS ARE BASED ON NUMBER OF TISSUES EXAMINED.
             IN OTHER TISSUES/ORGANS, RATES ARE BASED ON NUMBER OF ANIMALS NECROPSIED.
                                                                    
                                                    ----------------
                                                    Adrenal Cortex
                                                    Adrenal Medulla
                                                    Bone Marrow
                                                    Brain
                                                    Clitoral Gland
                                                    Clitoral/Preputial Gland
                                                    Epididymis
                                                    Heart
                                                    Islets, Pancreatic
                                                    Kidney
                                                    Larynx
                                                    Liver
                                                    Lung
                                                    Nose
                                                    Ovary
                                                    Pancreas
                                                    Parathyroid Gland
                                                    Pituitary Gland
                                                    Preputial Gland
                                                    Prostate
                                                    Salivary Glands
                                                    Spleen
                                                    Testes
                                                    Thymus
                                                    Thyroid Gland
                                                    Urinary Bladder
NTP                                        STATISTICAL ANALYSIS OF PRIMARY TUMORS                              REPORT: PEIRPT08     
LAB: Battelle Northwest                                     TETRAHYDROFURAN                                    DATE: 02/20/96       
EXPERIMENT: 05181 TEST: 03                                                                                     TIME: 16:11:01       
TEST TYPE:  CHRONIC                             CAGES FROM 0000 TO LAST CAGE                                                        
CONT: N01-ES-95259                              ROUTE: RESPIRATORY EXPOSURE WHOLE BODY                         NTP C#: 60560C       
PATHOLOGIST: R. RENNE                                                                                          CAS: 0109-99-9       


                                     SUMMARY OF STATISTICALLY SIGNIFICANT (P<=.05) RESULTS
                                        IN THE ANALYSIS OF THE STUDY OF TETRAHYDROFURAN
              ====================================================================================================
                                                           MALE RATS
                                                          -------------
                  ORGAN                               MORPHOLOGY
                 -------                             ------------
              Adrenal Medulla               Pheochromocytoma Malignant
              Clitoral/Preputial Gland      Carcinoma or Adenoma
              Kidney: Renal Tubule          Carcinoma
                                            Carcinoma or Adenoma
              Mammary Gland                 Fibroadenoma
                                            Fibroma, Fibroadenoma or Adenoma
                                            Fibroma, Fibroadenoma, Carcinoma, or Adenoma
              Pituitary Gland: Pars Distalis or Unspecified Site
                                            Adenoma
              Testes                        Adenoma
              ====================================================================================================
                                                           FEMALE RATS
                                                          -------------
                  ORGAN                               MORPHOLOGY
                 -------                             ------------
              Mammary Gland                 Fibroadenoma
                                            Fibroma, Fibroadenoma or Adenoma
              All Organs                    Benign Tumors
              ====================================================================================================
         DATE: 02/21/96                     EXPERIMENT: 05181 TEST: 03                                                 PAGE   1
                             STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- TETRAHYDROFURAN
                                                 TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   CONTROL      200 PPM      600 PPM      1800 PPM  |   CONTROL      200 PPM      600 PPM      1800 PPM  |
|                       |                                                    |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Adrenal Medulla                                                                                                                  |
|     Pheochromocytoma Benign                                                                                                     |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            | 18/48 (38%)  11/50 (22%)  13/50 (26%)  14/49 (29%) |  0/50 (0%)    1/50 (2%)    3/49 (6%)    3/50 (6%)  |
|ADJUSTED (b)           |  71.9%        60.9%        61.4%        70.0%      |   0.0%         2.4%         9.6%        10.3%      |
|TERMINAL (d)           |  5/11 (45%)   1/6 (17%)    1/5 (20%)    2/6 (33%)  |  0/25 (0%)    0/25 (0%)    2/26 (8%)    2/26 (8%)  |
|FIRST INCIDENCE (DAYS) |   563          575          517          447       |   ---          614          538          641       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.453      P=0.404N     P=0.535      P=0.536    |  P=0.111      P=0.505      P=0.135      P=0.122    |
|INCIDENTAL TUMOR       |  P=0.282N     P=0.071N     P=0.136N     P=0.138N   |  P=0.178      P=0.419      P=0.076      P=0.157    |
|LOGISTIC REGRESSION    |  P=0.421N     P=0.087N     P=0.170N     P=0.227N   |  P=0.109      P=0.495      P=0.113      P=0.120    |
|COCHRAN-ARMITAGE       |  P=0.442N                                          |  P=0.108                                           |
|FISHER EXACT           |               P=0.072N     P=0.157N     P=0.236N   |               P=0.500      P=0.117      P=0.121    |
|=================================================================================================================================|
|                                                                                                                                 |
|Adrenal Medulla                                                                                                                  |
|     Pheochromocytoma Malignant                                                                                                  |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  0/48 (0%)    1/50 (2%)    3/50 (6%)    1/49 (2%)  |  2/50 (4%)    0/50 (0%)    0/49 (0%)    1/50 (2%)  |
|ADJUSTED (b)           |   0.0%         5.3%        35.1%        12.5%      |   5.7%         0.0%         0.0%         3.8%      |
|TERMINAL (d)           |  0/11 (0%)    0/6 (0%)     1/5 (20%)    0/6 (0%)   |  0/25 (0%)    0/25 (0%)    0/26 (0%)    1/26 (4%)  |
|FIRST INCIDENCE (DAYS) |   ---          660          590          727       |   642          ---          ---          733 (T)   |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.429      P=0.462      P=0.047 *    P=0.375    |  P=0.661N     P=0.240N     P=0.251N     P=0.520N   |
|INCIDENTAL TUMOR       |  P=0.557      P=0.529      P=0.106      P=0.586    |  P=0.620N     P=0.265N     P=0.200N     P=0.484N   |
|LOGISTIC REGRESSION    |  P=0.511      P=0.503      P=0.107      P=0.432    |  P=0.646N     P=0.236N     P=0.239N     P=0.498N   |
|COCHRAN-ARMITAGE       |  P=0.514                                           |  P=0.646N                                          |
|FISHER EXACT           |               P=0.510      P=0.129      P=0.505    |               P=0.247N     P=0.253N     P=0.500N   |
|=================================================================================================================================|
         DATE: 02/21/96                     EXPERIMENT: 05181 TEST: 03                                                 PAGE   2
                             STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- TETRAHYDROFURAN
                                                 TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   CONTROL      200 PPM      600 PPM      1800 PPM  |   CONTROL      200 PPM      600 PPM      1800 PPM  |
|                       |                                                    |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Adrenal Medulla                                                                                                                  |
|     Pheochromocytoma: Benign, Complex, Malignant, NOS                                                                           |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            | 18/48 (38%)  12/50 (24%)  16/50 (32%)  16/49 (33%) |  2/50 (4%)    1/50 (2%)    3/49 (6%)    4/50 (8%)  |
|ADJUSTED (b)           |  71.9%        63.1%        76.5%        74.7%      |   5.7%         2.4%         9.6%        14.0%      |
|TERMINAL (d)           |  5/11 (45%)   1/6 (17%)    2/5 (40%)    2/6 (33%)  |  0/25 (0%)    0/25 (0%)    2/26 (8%)    3/26 (12%) |
|FIRST INCIDENCE (DAYS) |   563          575          517          447       |   642          614          538          641       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.313      P=0.490N     P=0.270      P=0.370    |  P=0.164      P=0.497N     P=0.510      P=0.327    |
|INCIDENTAL TUMOR       |  P=0.421N     P=0.106N     P=0.353N     P=0.257N   |  P=0.247      P=0.578N     P=0.462      P=0.393    |
|LOGISTIC REGRESSION    |  P=0.536      P=0.134N     P=0.397N     P=0.387N   |  P=0.167      P=0.501N     P=0.489      P=0.337    |
|COCHRAN-ARMITAGE       |  P=0.513                                           |  P=0.165                                           |
|FISHER EXACT           |               P=0.109N     P=0.360N     P=0.387N   |               P=0.500N     P=0.490      P=0.339    |
|=================================================================================================================================|
|                                                                                                                                 |
|Bone                                                                                                                             |
|     Osteosarcoma                                                                                                                |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #        |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  0/50 (0%)    0/50 (0%)    2/50 (4%)    0/50 (0%)  |  1/50 (2%)    0/50 (0%)    0/50 (0%)    0/50 (0%)  |
|ADJUSTED (b)           |   0.0%         0.0%        14.1%         0.0%      |   4.0%         0.0%         0.0%         0.0%      |
|TERMINAL (d)           |  0/12 (0%)    0/6 (0%)     0/5 (0%)     0/6 (0%)   |  1/25 (4%)    0/25 (0%)    0/26 (0%)    0/26 (0%)  |
|FIRST INCIDENCE (DAYS) |   ---          ---          626          ---       |   733 (T)      ---          ---          ---       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.717N       (e)        P=0.184        (e)      |  P=0.465N     P=0.500N     P=0.492N     P=0.492N   |
|INCIDENTAL TUMOR       |  P=0.670N       (e)        P=0.304        (e)      |  P=0.465N     P=0.500N     P=0.492N     P=0.492N   |
|LOGISTIC REGRESSION    |  P=0.696N       (e)        P=0.226        (e)      |  P=0.465N     P=0.500N     P=0.492N     P=0.492N   |
|COCHRAN-ARMITAGE       |  P=0.695N                                          |  P=0.471N                                          |
|FISHER EXACT           |                 (e)        P=0.247        (e)      |               P=0.500N     P=0.500N     P=0.500N   |
|=================================================================================================================================|
         DATE: 02/21/96                     EXPERIMENT: 05181 TEST: 03                                                 PAGE   3
                             STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- TETRAHYDROFURAN
                                                 TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   CONTROL      200 PPM      600 PPM      1800 PPM  |   CONTROL      200 PPM      600 PPM      1800 PPM  |
|                       |                                                    |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Clitoral/Preputial Gland                                                                                                         |
|     Adenoma                                                                                                                     |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  2/49 (4%)    2/50 (4%)    0/50 (0%)    2/50 (4%)  |  1/48 (2%)    0/48 (0%)    0/46 (0%)    0/49 (0%)  |
|ADJUSTED (b)           |  11.0%         9.5%         0.0%         9.7%      |   4.2%         0.0%         0.0%         0.0%      |
|TERMINAL (d)           |  1/11 (9%)    0/6 (0%)     0/5 (0%)     0/6 (0%)   |  1/24 (4%)    0/24 (0%)    0/26 (0%)    0/25 (0%)  |
|FIRST INCIDENCE (DAYS) |   406          439          ---          583       |   733 (T)      ---          ---          ---       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.578      P=0.632      P=0.323N     P=0.636    |  P=0.465N     P=0.500N     P=0.484N     P=0.492N   |
|INCIDENTAL TUMOR       |  P=0.628N     P=0.674N     P=0.367N     P=0.693N   |  P=0.465N     P=0.500N     P=0.484N     P=0.492N   |
|LOGISTIC REGRESSION    |  P=0.607      P=0.670      P=0.250N     P=0.696    |  P=0.465N     P=0.500N     P=0.484N     P=0.492N   |
|COCHRAN-ARMITAGE       |  P=0.621                                           |  P=0.468N                                          |
|FISHER EXACT           |               P=0.684N     P=0.242N     P=0.684N   |               P=0.500N     P=0.511N     P=0.495N   |
|=================================================================================================================================|
|                                                                                                                                 |
|Clitoral/Preputial Gland                                                                                                         |
|     Carcinoma                                                                                                                   |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  3/49 (6%)    1/50 (2%)    0/50 (0%)    4/50 (8%)  |  1/48 (2%)    1/48 (2%)    1/46 (2%)    3/49 (6%)  |
|ADJUSTED (b)           |   7.0%         2.1%         0.0%        30.3%      |   4.2%         4.2%         3.8%        10.0%      |
|TERMINAL (d)           |  0/11 (0%)    0/6 (0%)     0/5 (0%)     1/6 (17%)  |  1/24 (4%)    1/24 (4%)    1/26 (4%)    2/25 (8%)  |
|FIRST INCIDENCE (DAYS) |   453          503          ---          607       |   733 (T)      733 (T)      733 (T)      498       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.184      P=0.306N     P=0.113N     P=0.427    |  P=0.164      P=0.763      P=0.745N     P=0.319    |
|INCIDENTAL TUMOR       |  P=0.227      P=0.195N     P=0.132N     P=0.549    |  P=0.186      P=0.763      P=0.745N     P=0.353    |
|LOGISTIC REGRESSION    |  P=0.195      P=0.398N     P=0.148N     P=0.503    |  P=0.162      P=0.763      P=0.745N     P=0.314    |
|COCHRAN-ARMITAGE       |  P=0.208                                           |  P=0.164                                           |
|FISHER EXACT           |               P=0.301N     P=0.117N     P=0.511    |               P=0.753N     P=0.742      P=0.316    |
|=================================================================================================================================|
         DATE: 02/21/96                     EXPERIMENT: 05181 TEST: 03                                                 PAGE   4
                             STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- TETRAHYDROFURAN
                                                 TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   CONTROL      200 PPM      600 PPM      1800 PPM  |   CONTROL      200 PPM      600 PPM      1800 PPM  |
|                       |                                                    |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Clitoral/Preputial Gland                                                                                                         |
|     Carcinoma or Adenoma                                                                                                        |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  5/49 (10%)   3/50 (6%)    0/50 (0%)    6/50 (12%) |  2/48 (4%)    1/48 (2%)    1/46 (2%)    3/49 (6%)  |
|ADJUSTED (b)           |  17.2%        11.4%         0.0%        37.1%      |   8.3%         4.2%         3.8%        10.0%      |
|TERMINAL (d)           |  1/11 (9%)    0/6 (0%)     0/5 (0%)     1/6 (17%)  |  2/24 (8%)    1/24 (4%)    1/26 (4%)    2/25 (8%)  |
|FIRST INCIDENCE (DAYS) |   406          439          ---          583       |   733 (T)      733 (T)      733 (T)      498       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.217      P=0.405N     P=0.046N*    P=0.404    |  P=0.294      P=0.500N     P=0.472N     P=0.517    |
|INCIDENTAL TUMOR       |  P=0.287      P=0.247N     P=0.054N     P=0.542    |  P=0.318      P=0.500N     P=0.472N     P=0.552    |
|LOGISTIC REGRESSION    |  P=0.236      P=0.444N     P=0.041N*    P=0.502    |  P=0.286      P=0.500N     P=0.472N     P=0.511    |
|COCHRAN-ARMITAGE       |  P=0.256                                           |  P=0.292                                           |
|FISHER EXACT           |               P=0.346N     P=0.027N*    P=0.514    |               P=0.500N     P=0.516N     P=0.510    |
|=================================================================================================================================|
|                                                                                                                                 |
|Islets, Pancreatic                                                                                                               |
|     Adenoma                                                                                                                     |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  4/50 (8%)    2/50 (4%)    1/50 (2%)    2/49 (4%)  |  1/48 (2%)    1/50 (2%)    0/50 (0%)    1/49 (2%)  |
|ADJUSTED (b)           |  19.9%         5.9%         5.6%        22.2%      |   2.5%         3.2%         0.0%         2.7%      |
|TERMINAL (d)           |  1/12 (8%)    0/6 (0%)     0/5 (0%)     1/6 (17%)  |  0/25 (0%)    0/25 (0%)    0/26 (0%)    0/26 (0%)  |
|FIRST INCIDENCE (DAYS) |   547          575          673          689       |   634          705          ---          634       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.451N     P=0.450N     P=0.331N     P=0.516N   |  P=0.657      P=0.757      P=0.505N     P=0.744    |
|INCIDENTAL TUMOR       |  P=0.377N     P=0.326N     P=0.165N     P=0.355N   |  P=0.631N     P=0.735      P=0.419N     P=0.647N   |
|LOGISTIC REGRESSION    |  P=0.386N     P=0.335N     P=0.185N     P=0.365N   |  P=0.674      P=0.754N     P=0.511N     P=0.759    |
|COCHRAN-ARMITAGE       |  P=0.385N                                          |  P=0.678                                           |
|FISHER EXACT           |               P=0.339N     P=0.181N     P=0.349N   |               P=0.742N     P=0.490N     P=0.747N   |
|=================================================================================================================================|
         DATE: 02/21/96                     EXPERIMENT: 05181 TEST: 03                                                 PAGE   5
                             STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- TETRAHYDROFURAN
                                                 TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   CONTROL      200 PPM      600 PPM      1800 PPM  |   CONTROL      200 PPM      600 PPM      1800 PPM  |
|                       |                                                    |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Islets, Pancreatic                                                                                                               |
|     Carcinoma                                                                                                                   |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  1/50 (2%)    2/50 (4%)    2/50 (4%)    3/49 (6%)  |  1/48 (2%)    1/50 (2%)    1/50 (2%)    1/49 (2%)  |
|ADJUSTED (b)           |   8.3%        19.0%        27.3%        14.1%      |   4.0%         4.0%         3.8%         3.8%      |
|TERMINAL (d)           |  1/12 (8%)    1/6 (17%)    1/5 (20%)    0/6 (0%)   |  1/25 (4%)    1/25 (4%)    1/26 (4%)    1/26 (4%)  |
|FIRST INCIDENCE (DAYS) |   733 (T)      575          707          635       |   733 (T)      733 (T)      733 (T)      733 (T)   |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.205      P=0.348      P=0.263      P=0.240    |  P=0.657N     P=0.763      P=0.754N     P=0.754N   |
|INCIDENTAL TUMOR       |  P=0.233      P=0.361      P=0.326      P=0.305    |  P=0.657N     P=0.763      P=0.754N     P=0.754N   |
|LOGISTIC REGRESSION    |  P=0.246      P=0.474      P=0.302      P=0.279    |  P=0.657N     P=0.763      P=0.754N     P=0.754N   |
|COCHRAN-ARMITAGE       |  P=0.259                                           |  P=0.668N                                          |
|FISHER EXACT           |               P=0.500      P=0.500      P=0.301    |               P=0.742N     P=0.742N     P=0.747N   |
|=================================================================================================================================|
|                                                                                                                                 |
|Islets, Pancreatic                                                                                                               |
|     Carcinoma or Adenoma                                                                                                        |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  5/50 (10%)   4/50 (8%)    3/50 (6%)    5/49 (10%) |  2/48 (4%)    2/50 (4%)    1/50 (2%)    2/49 (4%)  |
|ADJUSTED (b)           |  27.2%        23.9%        31.3%        33.2%      |   6.4%         7.1%         3.8%         6.4%      |
|TERMINAL (d)           |  2/12 (17%)   1/6 (17%)    1/5 (20%)    1/6 (17%)  |  1/25 (4%)    1/25 (4%)    1/26 (4%)    1/26 (4%)  |
|FIRST INCIDENCE (DAYS) |   547          575          673          635       |   634          705          733 (T)      634       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.394      P=0.591      P=0.638      P=0.437    |  P=0.614      P=0.690      P=0.494N     P=0.686    |
|INCIDENTAL TUMOR       |  P=0.477      P=0.573N     P=0.445N     P=0.618    |  P=0.577N     P=0.671      P=0.444N     P=0.595N   |
|LOGISTIC REGRESSION    |  P=0.484      P=0.505N     P=0.420N     P=0.593    |  P=0.618      P=0.688N     P=0.483N     P=0.688N   |
|COCHRAN-ARMITAGE       |  P=0.493                                           |  P=0.621                                           |
|FISHER EXACT           |               P=0.500N     P=0.357N     P=0.617    |               P=0.676N     P=0.485N     P=0.684N   |
|=================================================================================================================================|
         DATE: 02/21/96                     EXPERIMENT: 05181 TEST: 03                                                 PAGE   6
                             STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- TETRAHYDROFURAN
                                                 TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   CONTROL      200 PPM      600 PPM      1800 PPM  |   CONTROL      200 PPM      600 PPM      1800 PPM  |
|                       |                                                    |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Kidney: Renal Tubule                                                                                                             |
|     Adenoma                                                                                                                     |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  1/50 (2%)    1/50 (2%)    4/50 (8%)    3/50 (6%)  |  0/50 (0%)    0/50 (0%)    0/50 (0%)    0/50 (0%)  |
|ADJUSTED (b)           |   8.3%        16.7%        18.8%        18.6%      |   0.0%         0.0%         0.0%         0.0%      |
|TERMINAL (d)           |  1/12 (8%)    1/6 (17%)    0/5 (0%)     0/6 (0%)   |  0/25 (0%)    0/25 (0%)    0/26 (0%)    0/26 (0%)  |
|FIRST INCIDENCE (DAYS) |   733 (T)      733 (T)      631          668       |   ---          ---          ---          ---       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.195      P=0.602      P=0.120      P=0.213    |    (e)          (e)          (e)          (e)      |
|INCIDENTAL TUMOR       |  P=0.281      P=0.602      P=0.184      P=0.356    |    (e)          (e)          (e)          (e)      |
|LOGISTIC REGRESSION    |  P=0.213      P=0.602      P=0.159      P=0.262    |    (e)          (e)          (e)          (e)      |
|COCHRAN-ARMITAGE       |  P=0.224                                           |    (e)                                             |
|FISHER EXACT           |               P=0.753N     P=0.181      P=0.309    |                 (e)          (e)          (e)      |
|=================================================================================================================================|
|                                                                                                                                 |
|Kidney: Renal Tubule                                                                                                             |
|     Carcinoma                                                                                                                   |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  0/50 (0%)    0/50 (0%)    0/50 (0%)    2/50 (4%)  |  1/50 (2%)    0/50 (0%)    0/50 (0%)    0/50 (0%)  |
|ADJUSTED (b)           |   0.0%         0.0%         0.0%        24.2%      |   4.0%         0.0%         0.0%         0.0%      |
|TERMINAL (d)           |  0/12 (0%)    0/6 (0%)     0/5 (0%)     1/6 (17%)  |  1/25 (4%)    0/25 (0%)    0/26 (0%)    0/26 (0%)  |
|FIRST INCIDENCE (DAYS) |   ---          ---          ---          714       |   733 (T)      ---          ---          ---       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.026 *      (e)          (e)        P=0.132    |  P=0.465N     P=0.500N     P=0.492N     P=0.492N   |
|INCIDENTAL TUMOR       |  P=0.043 *      (e)          (e)        P=0.204    |  P=0.465N     P=0.500N     P=0.492N     P=0.492N   |
|LOGISTIC REGRESSION    |  P=0.031 *      (e)          (e)        P=0.163    |  P=0.465N     P=0.500N     P=0.492N     P=0.492N   |
|COCHRAN-ARMITAGE       |  P=0.042 *                                         |  P=0.471N                                          |
|FISHER EXACT           |                 (e)          (e)        P=0.247    |               P=0.500N     P=0.500N     P=0.500N   |
|=================================================================================================================================|
         DATE: 02/21/96                     EXPERIMENT: 05181 TEST: 03                                                 PAGE   7
                             STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- TETRAHYDROFURAN
                                                 TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   CONTROL      200 PPM      600 PPM      1800 PPM  |   CONTROL      200 PPM      600 PPM      1800 PPM  |
|                       |                                                    |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Kidney: Renal Tubule                                                                                                             |
|     Carcinoma or Adenoma                                                                                                        |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  1/50 (2%)    1/50 (2%)    4/50 (8%)    5/50 (10%) |  1/50 (2%)    0/50 (0%)    0/50 (0%)    0/50 (0%)  |
|ADJUSTED (b)           |   8.3%        16.7%        18.8%        38.3%      |   4.0%         0.0%         0.0%         0.0%      |
|TERMINAL (d)           |  1/12 (8%)    1/6 (17%)    0/5 (0%)     1/6 (17%)  |  1/25 (4%)    0/25 (0%)    0/26 (0%)    0/26 (0%)  |
|FIRST INCIDENCE (DAYS) |   733 (T)      733 (T)      631          668       |   733 (T)      ---          ---          ---       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.031 *    P=0.602      P=0.120      P=0.042 *  |  P=0.465N     P=0.500N     P=0.492N     P=0.492N   |
|INCIDENTAL TUMOR       |  P=0.060      P=0.602      P=0.184      P=0.107    |  P=0.465N     P=0.500N     P=0.492N     P=0.492N   |
|LOGISTIC REGRESSION    |  P=0.037 *    P=0.602      P=0.159      P=0.065    |  P=0.465N     P=0.500N     P=0.492N     P=0.492N   |
|COCHRAN-ARMITAGE       |  P=0.044 *                                         |  P=0.471N                                          |
|FISHER EXACT           |               P=0.753N     P=0.181      P=0.102    |               P=0.500N     P=0.500N     P=0.500N   |
|=================================================================================================================================|
|                                                                                                                                 |
|Lung                                                                                                                             |
|     Alveolar/Bronchiolar Adenoma                                                                                                |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  0/50 (0%)    3/50 (6%)    1/50 (2%)    0/50 (0%)  |  1/50 (2%)    0/50 (0%)    0/49 (0%)    0/50 (0%)  |
|ADJUSTED (b)           |   0.0%        15.2%         3.1%         0.0%      |   4.0%         0.0%         0.0%         0.0%      |
|TERMINAL (d)           |  0/12 (0%)    0/6 (0%)     0/5 (0%)     0/6 (0%)   |  1/25 (4%)    0/25 (0%)    0/26 (0%)    0/26 (0%)  |
|FIRST INCIDENCE (DAYS) |   ---          540          621          ---       |   733 (T)      ---          ---          ---       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.308N     P=0.097      P=0.513        (e)      |  P=0.465N     P=0.500N     P=0.492N     P=0.492N   |
|INCIDENTAL TUMOR       |  P=0.238N     P=0.161      P=0.572        (e)      |  P=0.465N     P=0.500N     P=0.492N     P=0.492N   |
|LOGISTIC REGRESSION    |  P=0.280N     P=0.121      P=0.500        (e)      |  P=0.465N     P=0.500N     P=0.492N     P=0.492N   |
|COCHRAN-ARMITAGE       |  P=0.281N                                          |  P=0.471N                                          |
|FISHER EXACT           |               P=0.121      P=0.500        (e)      |               P=0.500N     P=0.505N     P=0.500N   |
|=================================================================================================================================|
         DATE: 02/21/96                     EXPERIMENT: 05181 TEST: 03                                                 PAGE   8
                             STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- TETRAHYDROFURAN
                                                 TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   CONTROL      200 PPM      600 PPM      1800 PPM  |   CONTROL      200 PPM      600 PPM      1800 PPM  |
|                       |                                                    |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Lung                                                                                                                             |
|     Alveolar/Bronchiolar Carcinoma or Alveolar/Bronchiolar Adenoma                                                              |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  0/50 (0%)    3/50 (6%)    2/50 (4%)    0/50 (0%)  |  1/50 (2%)    0/50 (0%)    0/49 (0%)    0/50 (0%)  |
|ADJUSTED (b)           |   0.0%        15.2%         6.3%         0.0%      |   4.0%         0.0%         0.0%         0.0%      |
|TERMINAL (d)           |  0/12 (0%)    0/6 (0%)     0/5 (0%)     0/6 (0%)   |  1/25 (4%)    0/25 (0%)    0/26 (0%)    0/26 (0%)  |
|FIRST INCIDENCE (DAYS) |   ---          540          621          ---       |   733 (T)      ---          ---          ---       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.314N     P=0.097      P=0.258        (e)      |  P=0.465N     P=0.500N     P=0.492N     P=0.492N   |
|INCIDENTAL TUMOR       |  P=0.255N     P=0.161      P=0.320        (e)      |  P=0.465N     P=0.500N     P=0.492N     P=0.492N   |
|LOGISTIC REGRESSION    |  P=0.289N     P=0.121      P=0.237        (e)      |  P=0.465N     P=0.500N     P=0.492N     P=0.492N   |
|COCHRAN-ARMITAGE       |  P=0.291N                                          |  P=0.471N                                          |
|FISHER EXACT           |               P=0.121      P=0.247        (e)      |               P=0.500N     P=0.505N     P=0.500N   |
|=================================================================================================================================|
|                                                                                                                                 |
|Mammary Gland                                                                                                                    |
|     Carcinoma                                                                                                                   |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #        |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  0/50 (0%)    0/50 (0%)    0/50 (0%)    0/50 (0%)  |  5/50 (10%)   5/50 (10%)   5/50 (10%)   3/50 (6%)  |
|ADJUSTED (b)           |   0.0%         0.0%         0.0%         0.0%      |  15.7%        17.3%        14.9%        10.1%      |
|TERMINAL (d)           |  0/12 (0%)    0/6 (0%)     0/5 (0%)     0/6 (0%)   |  2/25 (8%)    3/25 (12%)   1/26 (4%)    2/26 (8%)  |
|FIRST INCIDENCE (DAYS) |   ---          ---          ---          ---       |   642          651          547          630       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |    (e)          (e)          (e)          (e)      |  P=0.293N     P=0.615N     P=0.623      P=0.375N   |
|INCIDENTAL TUMOR       |    (e)          (e)          (e)          (e)      |  P=0.290N     P=0.617N     P=0.546N     P=0.332N   |
|LOGISTIC REGRESSION    |    (e)          (e)          (e)          (e)      |  P=0.272N     P=0.623N     P=0.616N     P=0.354N   |
|COCHRAN-ARMITAGE       |    (e)                                             |  P=0.274N                                          |
|FISHER EXACT           |                 (e)          (e)          (e)      |               P=0.630N     P=0.630N     P=0.357N   |
|=================================================================================================================================|
         DATE: 02/21/96                     EXPERIMENT: 05181 TEST: 03                                                 PAGE   9
                             STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- TETRAHYDROFURAN
                                                 TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   CONTROL      200 PPM      600 PPM      1800 PPM  |   CONTROL      200 PPM      600 PPM      1800 PPM  |
|                       |                                                    |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Mammary Gland                                                                                                                    |
|     Carcinoma or Adenoma                                                                                                        |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #        |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  0/50 (0%)    0/50 (0%)    0/50 (0%)    0/50 (0%)  |  5/50 (10%)   5/50 (10%)   5/50 (10%)   3/50 (6%)  |
|ADJUSTED (b)           |   0.0%         0.0%         0.0%         0.0%      |  15.7%        17.3%        14.9%        10.1%      |
|TERMINAL (d)           |  0/12 (0%)    0/6 (0%)     0/5 (0%)     0/6 (0%)   |  2/25 (8%)    3/25 (12%)   1/26 (4%)    2/26 (8%)  |
|FIRST INCIDENCE (DAYS) |   ---          ---          ---          ---       |   642          651          547          630       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |    (e)          (e)          (e)          (e)      |  P=0.293N     P=0.615N     P=0.623      P=0.375N   |
|INCIDENTAL TUMOR       |    (e)          (e)          (e)          (e)      |  P=0.290N     P=0.617N     P=0.546N     P=0.332N   |
|LOGISTIC REGRESSION    |    (e)          (e)          (e)          (e)      |  P=0.272N     P=0.623N     P=0.616N     P=0.354N   |
|COCHRAN-ARMITAGE       |    (e)                                             |  P=0.274N                                          |
|FISHER EXACT           |                 (e)          (e)          (e)      |               P=0.630N     P=0.630N     P=0.357N   |
|=================================================================================================================================|
|                                                                                                                                 |
|Mammary Gland                                                                                                                    |
|     Fibroadenoma                                                                                                                |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #        |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  0/50 (0%)    2/50 (4%)    3/50 (6%)    4/50 (8%)  | 23/50 (46%)  22/50 (44%)  29/50 (58%)  31/50 (62%) |
|ADJUSTED (b)           |   0.0%        14.7%        12.3%        24.8%      |  68.8%        61.3%        73.1%        79.3%      |
|TERMINAL (d)           |  0/12 (0%)    0/6 (0%)     0/5 (0%)     0/6 (0%)   | 15/25 (60%)  12/25 (48%)  16/26 (62%)  18/26 (69%) |
|FIRST INCIDENCE (DAYS) |   ---          551          551          583       |   634          478          519          478       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.061      P=0.175      P=0.116      P=0.041 *  |  P=0.066      P=0.468N     P=0.227      P=0.113    |
|INCIDENTAL TUMOR       |  P=0.088      P=0.275      P=0.182      P=0.087    |  P=0.025 *    P=0.419N     P=0.235      P=0.037 *  |
|LOGISTIC REGRESSION    |  P=0.076      P=0.238      P=0.120      P=0.062    |  P=0.031 *    P=0.478N     P=0.211      P=0.056    |
|COCHRAN-ARMITAGE       |  P=0.075                                           |  P=0.038 *                                         |
|FISHER EXACT           |               P=0.247      P=0.121      P=0.059    |               P=0.500N     P=0.158      P=0.080    |
|=================================================================================================================================|
         DATE: 02/21/96                     EXPERIMENT: 05181 TEST: 03                                                 PAGE  10
                             STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- TETRAHYDROFURAN
                                                 TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   CONTROL      200 PPM      600 PPM      1800 PPM  |   CONTROL      200 PPM      600 PPM      1800 PPM  |
|                       |                                                    |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Mammary Gland                                                                                                                    |
|     Fibroma, Fibroadenoma or Adenoma                                                                                            |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #        |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  0/50 (0%)    2/50 (4%)    3/50 (6%)    4/50 (8%)  | 24/50 (48%)  22/50 (44%)  29/50 (58%)  31/50 (62%) |
|ADJUSTED (b)           |   0.0%        14.7%        12.3%        24.8%      |  71.9%        61.3%        73.1%        79.3%      |
|TERMINAL (d)           |  0/12 (0%)    0/6 (0%)     0/5 (0%)     0/6 (0%)   | 16/25 (64%)  12/25 (48%)  16/26 (62%)  18/26 (69%) |
|FIRST INCIDENCE (DAYS) |   ---          551          551          583       |   634          478          519          478       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.061      P=0.175      P=0.116      P=0.041 *  |  P=0.081      P=0.397N     P=0.284      P=0.150    |
|INCIDENTAL TUMOR       |  P=0.088      P=0.275      P=0.182      P=0.087    |  P=0.034 *    P=0.338N     P=0.303      P=0.058    |
|LOGISTIC REGRESSION    |  P=0.076      P=0.238      P=0.120      P=0.062    |  P=0.042 *    P=0.393N     P=0.277      P=0.083    |
|COCHRAN-ARMITAGE       |  P=0.075                                           |  P=0.050                                           |
|FISHER EXACT           |               P=0.247      P=0.121      P=0.059    |               P=0.421N     P=0.212      P=0.114    |
|=================================================================================================================================|
|                                                                                                                                 |
|Mammary Gland                                                                                                                    |
|     Fibroma, Fibroadenoma, Carcinoma, or Adenoma                                                                                |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #        |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  0/50 (0%)    2/50 (4%)    3/50 (6%)    4/50 (8%)  | 27/50 (54%)  25/50 (50%)  33/50 (66%)  32/50 (64%) |
|ADJUSTED (b)           |   0.0%        14.7%        12.3%        24.8%      |  74.3%        70.2%        77.8%        79.9%      |
|TERMINAL (d)           |  0/12 (0%)    0/6 (0%)     0/5 (0%)     0/6 (0%)   | 16/25 (64%)  15/25 (60%)  17/26 (65%)  18/26 (69%) |
|FIRST INCIDENCE (DAYS) |   ---          551          551          583       |   634          478          519          478       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.061      P=0.175      P=0.116      P=0.041 *  |  P=0.167      P=0.399N     P=0.245      P=0.249    |
|INCIDENTAL TUMOR       |  P=0.088      P=0.275      P=0.182      P=0.087    |  P=0.092      P=0.341N     P=0.269      P=0.131    |
|LOGISTIC REGRESSION    |  P=0.076      P=0.238      P=0.120      P=0.062    |  P=0.109      P=0.390N     P=0.219      P=0.180    |
|COCHRAN-ARMITAGE       |  P=0.075                                           |  P=0.119                                           |
|FISHER EXACT           |               P=0.247      P=0.121      P=0.059    |               P=0.421N     P=0.154      P=0.208    |
|=================================================================================================================================|
         DATE: 02/21/96                     EXPERIMENT: 05181 TEST: 03                                                 PAGE  11
                             STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- TETRAHYDROFURAN
                                                 TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   CONTROL      200 PPM      600 PPM      1800 PPM  |   CONTROL      200 PPM      600 PPM      1800 PPM  |
|                       |                                                    |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Oral Cavity (Oral Mucosa, Tongue, Pharynx, Tooth, Gingiva)                                                                       |
|     Papilloma Squamous or Papilloma                                                                                             |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #        |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  1/50 (2%)    0/50 (0%)    2/50 (4%)    2/50 (4%)  |  0/50 (0%)    1/50 (2%)    0/50 (0%)    1/50 (2%)  |
|ADJUSTED (b)           |   5.9%         0.0%        10.3%         7.4%      |   0.0%         4.0%         0.0%         3.8%      |
|TERMINAL (d)           |  0/12 (0%)    0/6 (0%)     0/5 (0%)     0/6 (0%)   |  0/25 (0%)    1/25 (4%)    0/26 (0%)    1/26 (4%)  |
|FIRST INCIDENCE (DAYS) |   705          ---          639          505       |   ---          733 (T)      ---          733 (T)   |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.272      P=0.553N     P=0.423      P=0.460    |  P=0.468      P=0.500        (e)        P=0.508    |
|INCIDENTAL TUMOR       |  P=0.346      P=0.471N     P=0.590      P=0.628    |  P=0.468      P=0.500        (e)        P=0.508    |
|LOGISTIC REGRESSION    |  P=0.271      P=0.536N     P=0.481      P=0.502    |  P=0.468      P=0.500        (e)        P=0.508    |
|COCHRAN-ARMITAGE       |  P=0.269                                           |  P=0.459                                           |
|FISHER EXACT           |               P=0.500N     P=0.500      P=0.500    |               P=0.500        (e)        P=0.500    |
|=================================================================================================================================|
|                                                                                                                                 |
|Oral Cavity (Oral Mucosa, Tongue, Pharynx, Tooth, Gingiva)                                                                       |
|     Squamous Cell Carcinoma, Papilloma Squamous, or Papilloma                                                                   |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #        |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  1/50 (2%)    0/50 (0%)    2/50 (4%)    2/50 (4%)  |  0/50 (0%)    1/50 (2%)    0/50 (0%)    1/50 (2%)  |
|ADJUSTED (b)           |   5.9%         0.0%        10.3%         7.4%      |   0.0%         4.0%         0.0%         3.8%      |
|TERMINAL (d)           |  0/12 (0%)    0/6 (0%)     0/5 (0%)     0/6 (0%)   |  0/25 (0%)    1/25 (4%)    0/26 (0%)    1/26 (4%)  |
|FIRST INCIDENCE (DAYS) |   705          ---          639          505       |   ---          733 (T)      ---          733 (T)   |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.272      P=0.553N     P=0.423      P=0.460    |  P=0.468      P=0.500        (e)        P=0.508    |
|INCIDENTAL TUMOR       |  P=0.346      P=0.471N     P=0.590      P=0.628    |  P=0.468      P=0.500        (e)        P=0.508    |
|LOGISTIC REGRESSION    |  P=0.271      P=0.536N     P=0.481      P=0.502    |  P=0.468      P=0.500        (e)        P=0.508    |
|COCHRAN-ARMITAGE       |  P=0.269                                           |  P=0.459                                           |
|FISHER EXACT           |               P=0.500N     P=0.500      P=0.500    |               P=0.500        (e)        P=0.500    |
|=================================================================================================================================|
         DATE: 02/21/96                     EXPERIMENT: 05181 TEST: 03                                                 PAGE  12
                             STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- TETRAHYDROFURAN
                                                 TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   CONTROL      200 PPM      600 PPM      1800 PPM  |   CONTROL      200 PPM      600 PPM      1800 PPM  |
|                       |                                                    |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Pituitary Gland: Pars Distalis or Unspecified Site                                                                               |
|     Adenoma                                                                                                                     |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            | 33/49 (67%)  34/49 (69%)  40/48 (83%)  29/50 (58%) | 33/49 (67%)  38/49 (78%)  38/50 (76%)  34/50 (68%) |
|ADJUSTED (b)           |  96.5%        90.5%       100.0%        86.5%      |  79.7%        92.4%        85.8%        89.2%      |
|TERMINAL (d)           | 11/12 (92%)   3/6 (50%)    5/5 (100%)   3/6 (50%)  | 17/25 (68%)  21/24 (88%)  20/26 (77%)  22/26 (85%) |
|FIRST INCIDENCE (DAYS) |   406          503          401          417       |   467          336          519          412       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.473N     P=0.138      P=0.014 *    P=0.402    |  P=0.422N     P=0.255      P=0.328      P=0.506    |
|INCIDENTAL TUMOR       |  P=0.066N     P=0.555      P=0.031 *    P=0.181N   |  P=0.387N     P=0.164      P=0.337      P=0.549    |
|LOGISTIC REGRESSION    |  P=0.091N     P=0.555      P=0.075      P=0.198N   |  P=0.349N     P=0.156      P=0.270      P=0.545    |
|COCHRAN-ARMITAGE       |  P=0.107N                                          |  P=0.363N                                          |
|FISHER EXACT           |               P=0.500      P=0.055      P=0.226N   |               P=0.183      P=0.232      P=0.558    |
|=================================================================================================================================|
|                                                                                                                                 |
|Skin                                                                                                                             |
|     Basal or Sq. Cell Carcinoma, Carcinoma, Basosq. Tumor (M or B), Basal                                                       |
|     Cell Adenoma, Adenoma, Papilloma, Sq Papilloma, Keratoacanthoma, Trichoepithelioma                                          |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #        |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  4/50 (8%)    6/50 (12%)   1/50 (2%)    4/50 (8%)  |  2/50 (4%)    1/50 (2%)    1/50 (2%)    0/50 (0%)  |
|ADJUSTED (b)           |  23.0%        28.0%        20.0%        27.9%      |   8.0%         4.0%         3.8%         0.0%      |
|TERMINAL (d)           |  2/12 (17%)   0/6 (0%)     1/5 (20%)    1/6 (17%)  |  2/25 (8%)    1/25 (4%)    1/26 (4%)    0/26 (0%)  |
|FIRST INCIDENCE (DAYS) |   575          607          733 (T)      594       |   733 (T)      733 (T)      733 (T)      ---       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.562N     P=0.248      P=0.348N     P=0.498    |  P=0.184N     P=0.500N     P=0.486N     P=0.229N   |
|INCIDENTAL TUMOR       |  P=0.534N     P=0.365      P=0.303N     P=0.549    |  P=0.184N     P=0.500N     P=0.486N     P=0.229N   |
|LOGISTIC REGRESSION    |  P=0.480N     P=0.351      P=0.210N     P=0.635    |  P=0.184N     P=0.500N     P=0.486N     P=0.229N   |
|COCHRAN-ARMITAGE       |  P=0.477N                                          |  P=0.193N                                          |
|FISHER EXACT           |               P=0.370      P=0.181N     P=0.643N   |               P=0.500N     P=0.500N     P=0.247N   |
|=================================================================================================================================|
         DATE: 02/21/96                     EXPERIMENT: 05181 TEST: 03                                                 PAGE  13
                             STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- TETRAHYDROFURAN
                                                 TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   CONTROL      200 PPM      600 PPM      1800 PPM  |   CONTROL      200 PPM      600 PPM      1800 PPM  |
|                       |                                                    |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Skin                                                                                                                             |
|     Fibroma                                                                                                                     |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #        |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  2/50 (4%)    5/50 (10%)   4/50 (8%)    2/50 (4%)  |  0/50 (0%)    0/50 (0%)    2/50 (4%)    1/50 (2%)  |
|ADJUSTED (b)           |  13.7%        40.2%        34.8%        23.1%      |   0.0%         0.0%         7.7%         3.8%      |
|TERMINAL (d)           |  1/12 (8%)    2/6 (33%)    1/5 (20%)    1/6 (17%)  |  0/25 (0%)    0/25 (0%)    2/26 (8%)    1/26 (4%)  |
|FIRST INCIDENCE (DAYS) |   705          575          629          704       |   ---          ---          733 (T)      733 (T)   |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.487N     P=0.104      P=0.150      P=0.506    |  P=0.364        (e)        P=0.246      P=0.508    |
|INCIDENTAL TUMOR       |  P=0.422N     P=0.141      P=0.281      P=0.657    |  P=0.364        (e)        P=0.246      P=0.508    |
|LOGISTIC REGRESSION    |  P=0.375N     P=0.187      P=0.260      P=0.610    |  P=0.364        (e)        P=0.246      P=0.508    |
|COCHRAN-ARMITAGE       |  P=0.363N                                          |  P=0.354                                           |
|FISHER EXACT           |               P=0.218      P=0.339      P=0.691N   |                 (e)        P=0.247      P=0.500    |
|=================================================================================================================================|
|                                                                                                                                 |
|Skin                                                                                                                             |
|     Fibroma, Fibrosarcoma, Sarcoma, Myxoma, Myxosarcoma, or Fibrous Histiocytoma                                                |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #        |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  2/50 (4%)    5/50 (10%)   4/50 (8%)    3/50 (6%)  |  0/50 (0%)    1/50 (2%)    2/50 (4%)    2/50 (4%)  |
|ADJUSTED (b)           |  13.7%        40.2%        34.8%        24.9%      |   0.0%         4.0%         7.7%         7.7%      |
|TERMINAL (d)           |  1/12 (8%)    2/6 (33%)    1/5 (20%)    1/6 (17%)  |  0/25 (0%)    1/25 (4%)    2/26 (8%)    2/26 (8%)  |
|FIRST INCIDENCE (DAYS) |   705          575          629          516       |   ---          733 (T)      733 (T)      733 (T)   |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.520      P=0.104      P=0.150      P=0.326    |  P=0.238      P=0.500      P=0.246      P=0.246    |
|INCIDENTAL TUMOR       |  P=0.588      P=0.141      P=0.281      P=0.478    |  P=0.238      P=0.500      P=0.246      P=0.246    |
|LOGISTIC REGRESSION    |  P=0.553N     P=0.187      P=0.260      P=0.485    |  P=0.238      P=0.500      P=0.246      P=0.246    |
|COCHRAN-ARMITAGE       |  P=0.547N                                          |  P=0.228                                           |
|FISHER EXACT           |               P=0.218      P=0.339      P=0.500    |               P=0.500      P=0.247      P=0.247    |
|=================================================================================================================================|
         DATE: 02/21/96                     EXPERIMENT: 05181 TEST: 03                                                 PAGE  14
                             STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- TETRAHYDROFURAN
                                                 TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   CONTROL      200 PPM      600 PPM      1800 PPM  |   CONTROL      200 PPM      600 PPM      1800 PPM  |
|                       |                                                    |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Skin                                                                                                                             |
|     Keratoacanthoma                                                                                                             |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #        |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  3/50 (6%)    4/50 (8%)    1/50 (2%)    2/50 (4%)  |  1/50 (2%)    0/50 (0%)    1/50 (2%)    0/50 (0%)  |
|ADJUSTED (b)           |  15.3%        19.4%        20.0%         6.2%      |   4.0%         0.0%         3.8%         0.0%      |
|TERMINAL (d)           |  1/12 (8%)    0/6 (0%)     1/5 (20%)    0/6 (0%)   |  1/25 (4%)    0/25 (0%)    1/26 (4%)    0/26 (0%)  |
|FIRST INCIDENCE (DAYS) |   575          607          733 (T)      594       |   733 (T)      ---          733 (T)      ---       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.379N     P=0.399      P=0.456N     P=0.538N   |  P=0.451N     P=0.500N     P=0.754N     P=0.492N   |
|INCIDENTAL TUMOR       |  P=0.383N     P=0.524      P=0.403N     P=0.540N   |  P=0.451N     P=0.500N     P=0.754N     P=0.492N   |
|LOGISTIC REGRESSION    |  P=0.336N     P=0.495      P=0.325N     P=0.496N   |  P=0.451N     P=0.500N     P=0.754N     P=0.492N   |
|COCHRAN-ARMITAGE       |  P=0.338N                                          |  P=0.459N                                          |
|FISHER EXACT           |               P=0.500      P=0.309N     P=0.500N   |               P=0.500N     P=0.753N     P=0.500N   |
|=================================================================================================================================|
|                                                                                                                                 |
|Skin                                                                                                                             |
|     Squamous Cell Papilloma                                                                                                     |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #        |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  0/50 (0%)    2/50 (4%)    0/50 (0%)    0/50 (0%)  |  1/50 (2%)    1/50 (2%)    0/50 (0%)    0/50 (0%)  |
|ADJUSTED (b)           |   0.0%        10.6%         0.0%         0.0%      |   4.0%         4.0%         0.0%         0.0%      |
|TERMINAL (d)           |  0/12 (0%)    0/6 (0%)     0/5 (0%)     0/6 (0%)   |  1/25 (4%)    1/25 (4%)    0/26 (0%)    0/26 (0%)  |
|FIRST INCIDENCE (DAYS) |   ---          629          ---          ---       |   733 (T)      733 (T)      ---          ---       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.397N     P=0.215        (e)          (e)      |  P=0.298N     P=0.763      P=0.492N     P=0.492N   |
|INCIDENTAL TUMOR       |  P=0.352N     P=0.275        (e)          (e)      |  P=0.298N     P=0.763      P=0.492N     P=0.492N   |
|LOGISTIC REGRESSION    |  P=0.381N     P=0.230        (e)          (e)      |  P=0.298N     P=0.763      P=0.492N     P=0.492N   |
|COCHRAN-ARMITAGE       |  P=0.380N                                          |  P=0.305N                                          |
|FISHER EXACT           |               P=0.247        (e)          (e)      |               P=0.753N     P=0.500N     P=0.500N   |
|=================================================================================================================================|
         DATE: 02/21/96                     EXPERIMENT: 05181 TEST: 03                                                 PAGE  15
                             STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- TETRAHYDROFURAN
                                                 TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   CONTROL      200 PPM      600 PPM      1800 PPM  |   CONTROL      200 PPM      600 PPM      1800 PPM  |
|                       |                                                    |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Skin                                                                                                                             |
|     Squamous Cell Papilloma, Papilloma, Squamous Cell Carcinoma or Keratoacanthoma                                              |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #        |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  3/50 (6%)    6/50 (12%)   1/50 (2%)    3/50 (6%)  |  2/50 (4%)    1/50 (2%)    1/50 (2%)    0/50 (0%)  |
|ADJUSTED (b)           |  15.3%        28.0%        20.0%        21.8%      |   8.0%         4.0%         3.8%         0.0%      |
|TERMINAL (d)           |  1/12 (8%)    0/6 (0%)     1/5 (20%)    1/6 (17%)  |  2/25 (8%)    1/25 (4%)    1/26 (4%)    0/26 (0%)  |
|FIRST INCIDENCE (DAYS) |   575          607          733 (T)      594       |   733 (T)      733 (T)      733 (T)      ---       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.458N     P=0.175      P=0.456N     P=0.576    |  P=0.184N     P=0.500N     P=0.486N     P=0.229N   |
|INCIDENTAL TUMOR       |  P=0.448N     P=0.275      P=0.403N     P=0.576    |  P=0.184N     P=0.500N     P=0.486N     P=0.229N   |
|LOGISTIC REGRESSION    |  P=0.394N     P=0.235      P=0.325N     P=0.663N   |  P=0.184N     P=0.500N     P=0.486N     P=0.229N   |
|COCHRAN-ARMITAGE       |  P=0.395N                                          |  P=0.193N                                          |
|FISHER EXACT           |               P=0.243      P=0.309N     P=0.661N   |               P=0.500N     P=0.500N     P=0.247N   |
|=================================================================================================================================|
|                                                                                                                                 |
|Skin                                                                                                                             |
|     Squamous Cell Papilloma, Papilloma, or Keratoacanthoma                                                                      |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #        |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  3/50 (6%)    6/50 (12%)   1/50 (2%)    2/50 (4%)  |  2/50 (4%)    1/50 (2%)    1/50 (2%)    0/50 (0%)  |
|ADJUSTED (b)           |  15.3%        28.0%        20.0%         6.2%      |   8.0%         4.0%         3.8%         0.0%      |
|TERMINAL (d)           |  1/12 (8%)    0/6 (0%)     1/5 (20%)    0/6 (0%)   |  2/25 (8%)    1/25 (4%)    1/26 (4%)    0/26 (0%)  |
|FIRST INCIDENCE (DAYS) |   575          607          733 (T)      594       |   733 (T)      733 (T)      733 (T)      ---       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.262N     P=0.175      P=0.456N     P=0.538N   |  P=0.184N     P=0.500N     P=0.486N     P=0.229N   |
|INCIDENTAL TUMOR       |  P=0.242N     P=0.275      P=0.403N     P=0.540N   |  P=0.184N     P=0.500N     P=0.486N     P=0.229N   |
|LOGISTIC REGRESSION    |  P=0.219N     P=0.235      P=0.325N     P=0.496N   |  P=0.184N     P=0.500N     P=0.486N     P=0.229N   |
|COCHRAN-ARMITAGE       |  P=0.221N                                          |  P=0.193N                                          |
|FISHER EXACT           |               P=0.243      P=0.309N     P=0.500N   |               P=0.500N     P=0.500N     P=0.247N   |
|=================================================================================================================================|
         DATE: 02/21/96                     EXPERIMENT: 05181 TEST: 03                                                 PAGE  16
                             STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- TETRAHYDROFURAN
                                                 TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   CONTROL      200 PPM      600 PPM      1800 PPM  |   CONTROL      200 PPM      600 PPM      1800 PPM  |
|                       |                                                    |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Testes                                                                                                                           |
|     Adenoma                                                                                                                     |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            | 23/50 (46%)  31/50 (62%)  31/50 (62%)  34/50 (68%) |                                                    |
|ADJUSTED (b)           |  78.9%       100.0%       100.0%        96.8%      |                                                    |
|TERMINAL (d)           |  7/12 (58%)   6/6 (100%)   5/5 (100%)   5/6 (83%)  |                                                    |
|FIRST INCIDENCE (DAYS) |   546          439          561          505       |                                                    |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.040 *    P=0.013 *    P=0.009 **   P=0.009 ** |                                                    |
|INCIDENTAL TUMOR       |  P=0.054      P=0.047 *    P=0.081      P=0.024 *  |                                                    |
|LOGISTIC REGRESSION    |  P=0.036 *    P=0.062      P=0.077      P=0.018 *  |                                                    |
|COCHRAN-ARMITAGE       |  P=0.048 *                                         |                                                    |
|FISHER EXACT           |               P=0.080      P=0.080      P=0.021 *  |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Thyroid Gland: C-Cell                                                                                                            |
|     Adenoma                                                                                                                     |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  4/50 (8%)    4/50 (8%)    0/50 (0%)    4/50 (8%)  |  2/48 (4%)    3/50 (6%)    6/50 (12%)   4/49 (8%)  |
|ADJUSTED (b)           |  16.1%        41.3%         0.0%        28.1%      |   8.0%        10.4%        19.3%        14.3%      |
|TERMINAL (d)           |  1/12 (8%)    2/6 (33%)    0/5 (0%)     1/6 (17%)  |  2/25 (8%)    2/25 (8%)    3/26 (12%)   3/26 (12%) |
|FIRST INCIDENCE (DAYS) |   453          607          ---          607       |   733 (T)      651          649          691       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.465      P=0.468      P=0.098N     P=0.542    |  P=0.340      P=0.505      P=0.144      P=0.352    |
|INCIDENTAL TUMOR       |  P=0.538      P=0.573      P=0.082N     P=0.640N   |  P=0.269      P=0.514      P=0.152      P=0.320    |
|LOGISTIC REGRESSION    |  P=0.570      P=0.644      P=0.066N     P=0.640N   |  P=0.326      P=0.509      P=0.143      P=0.321    |
|COCHRAN-ARMITAGE       |  P=0.568                                           |  P=0.344                                           |
|FISHER EXACT           |               P=0.643N     P=0.059N     P=0.643N   |               P=0.520      P=0.148      P=0.349    |
|=================================================================================================================================|
         DATE: 02/21/96                     EXPERIMENT: 05181 TEST: 03                                                 PAGE  17
                             STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- TETRAHYDROFURAN
                                                 TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   CONTROL      200 PPM      600 PPM      1800 PPM  |   CONTROL      200 PPM      600 PPM      1800 PPM  |
|                       |                                                    |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Thyroid Gland: C-Cell                                                                                                            |
|     Carcinoma                                                                                                                   |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  2/50 (4%)    2/50 (4%)    3/50 (6%)    1/50 (2%)  |  2/48 (4%)    1/50 (2%)    2/50 (4%)    2/49 (4%)  |
|ADJUSTED (b)           |  12.9%        23.1%        35.4%         4.5%      |   8.0%         2.6%         6.4%         7.7%      |
|TERMINAL (d)           |  1/12 (8%)    1/6 (17%)    1/5 (20%)    0/6 (0%)   |  2/25 (8%)    0/25 (0%)    1/26 (4%)    2/26 (8%)  |
|FIRST INCIDENCE (DAYS) |   673          707          707          660       |   733 (T)      651          660          733 (T)   |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.493N     P=0.525      P=0.262      P=0.589N   |  P=0.530      P=0.494N     P=0.681N     P=0.683N   |
|INCIDENTAL TUMOR       |  P=0.351N     P=0.599      P=0.402      P=0.478N   |  P=0.493      P=0.482N     P=0.676N     P=0.683N   |
|LOGISTIC REGRESSION    |  P=0.415N     P=0.620      P=0.342      P=0.522N   |  P=0.524      P=0.493N     P=0.688N     P=0.683N   |
|COCHRAN-ARMITAGE       |  P=0.378N                                          |  P=0.534                                           |
|FISHER EXACT           |               P=0.691N     P=0.500      P=0.500N   |               P=0.485N     P=0.676N     P=0.684N   |
|=================================================================================================================================|
|                                                                                                                                 |
|Thyroid Gland: C-Cell                                                                                                            |
|     Carcinoma or Adenoma                                                                                                        |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  6/50 (12%)   6/50 (12%)   3/50 (6%)    5/50 (10%) |  4/48 (8%)    3/50 (6%)    8/50 (16%)   6/49 (12%) |
|ADJUSTED (b)           |  27.6%        59.4%        35.4%        31.4%      |  16.0%        10.4%        24.9%        21.8%      |
|TERMINAL (d)           |  2/12 (17%)   3/6 (50%)    1/5 (20%)    1/6 (17%)  |  4/25 (16%)   2/25 (8%)    4/26 (15%)   5/26 (19%) |
|FIRST INCIDENCE (DAYS) |   453          607          707          607       |   733 (T)      651          649          691       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.556      P=0.366      P=0.475N     P=0.612    |  P=0.260      P=0.496N     P=0.193      P=0.389    |
|INCIDENTAL TUMOR       |  P=0.449N     P=0.496      P=0.333N     P=0.484N   |  P=0.194      P=0.488N     P=0.202      P=0.363    |
|LOGISTIC REGRESSION    |  P=0.453N     P=0.597      P=0.247N     P=0.496N   |  P=0.237      P=0.489N     P=0.189      P=0.349    |
|COCHRAN-ARMITAGE       |  P=0.446N                                          |  P=0.260                                           |
|FISHER EXACT           |               P=0.620N     P=0.243N     P=0.500N   |               P=0.477N     P=0.199      P=0.383    |
|=================================================================================================================================|
         DATE: 02/21/96                     EXPERIMENT: 05181 TEST: 03                                                 PAGE  18
                             STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- TETRAHYDROFURAN
                                                 TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   CONTROL      200 PPM      600 PPM      1800 PPM  |   CONTROL      200 PPM      600 PPM      1800 PPM  |
|                       |                                                    |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Thyroid Gland: Follicular Cell                                                                                                   |
|     Adenoma                                                                                                                     |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  2/50 (4%)    0/50 (0%)    1/50 (2%)    0/50 (0%)  |  0/48 (0%)    0/50 (0%)    1/50 (2%)    0/49 (0%)  |
|ADJUSTED (b)           |   5.3%         0.0%         2.7%         0.0%      |   0.0%         0.0%         3.8%         0.0%      |
|TERMINAL (d)           |  0/12 (0%)    0/6 (0%)     0/5 (0%)     0/6 (0%)   |  0/25 (0%)    0/25 (0%)    1/26 (4%)    0/26 (0%)  |
|FIRST INCIDENCE (DAYS) |   514          ---          591          ---       |   ---          ---          733 (T)      ---       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.256N     P=0.233N     P=0.450N     P=0.232N   |  P=0.779N       (e)        P=0.508        (e)      |
|INCIDENTAL TUMOR       |  P=0.273N     P=0.184N     P=0.455N     P=0.219N   |  P=0.779N       (e)        P=0.508        (e)      |
|LOGISTIC REGRESSION    |  P=0.287N     P=0.266N     P=0.537N     P=0.263N   |  P=0.779N       (e)        P=0.508        (e)      |
|COCHRAN-ARMITAGE       |  P=0.266N                                          |  P=0.786N                                          |
|FISHER EXACT           |               P=0.247N     P=0.500N     P=0.247N   |                 (e)        P=0.510        (e)      |
|=================================================================================================================================|
|                                                                                                                                 |
|Thyroid Gland: Follicular Cell                                                                                                   |
|     Carcinoma or Adenoma                                                                                                        |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  3/50 (6%)    0/50 (0%)    2/50 (4%)    1/50 (2%)  |  0/48 (0%)    0/50 (0%)    1/50 (2%)    1/49 (2%)  |
|ADJUSTED (b)           |   9.4%         0.0%         5.7%         2.9%      |   0.0%         0.0%         3.8%         3.8%      |
|TERMINAL (d)           |  0/12 (0%)    0/6 (0%)     0/5 (0%)     0/6 (0%)   |  0/25 (0%)    0/25 (0%)    1/26 (4%)    1/26 (4%)  |
|FIRST INCIDENCE (DAYS) |   514          ---          591          594       |   ---          ---          733 (T)      733 (T)   |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.414N     P=0.131N     P=0.472N     P=0.296N   |  P=0.314        (e)        P=0.508      P=0.508    |
|INCIDENTAL TUMOR       |  P=0.430N     P=0.087N     P=0.413N     P=0.259N   |  P=0.314        (e)        P=0.508      P=0.508    |
|LOGISTIC REGRESSION    |  P=0.443N     P=0.127N     P=0.518N     P=0.320N   |  P=0.314        (e)        P=0.508      P=0.508    |
|COCHRAN-ARMITAGE       |  P=0.429N                                          |  P=0.305                                           |
|FISHER EXACT           |               P=0.121N     P=0.500N     P=0.309N   |                 (e)        P=0.510      P=0.505    |
|=================================================================================================================================|
         DATE: 02/21/96                     EXPERIMENT: 05181 TEST: 03                                                 PAGE  19
                             STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- TETRAHYDROFURAN
                                                 TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   CONTROL      200 PPM      600 PPM      1800 PPM  |   CONTROL      200 PPM      600 PPM      1800 PPM  |
|                       |                                                    |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Tongue                                                                                                                           |
|     Squamous Cell Papilloma                                                                                                     |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #        |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  1/50 (2%)    0/50 (0%)    2/50 (4%)    1/50 (2%)  |  0/50 (0%)    1/50 (2%)    0/50 (0%)    1/50 (2%)  |
|ADJUSTED (b)           |   5.9%         0.0%        10.3%         5.3%      |   0.0%         4.0%         0.0%         3.8%      |
|TERMINAL (d)           |  0/12 (0%)    0/6 (0%)     0/5 (0%)     0/6 (0%)   |  0/25 (0%)    1/25 (4%)    0/26 (0%)    1/26 (4%)  |
|FIRST INCIDENCE (DAYS) |   705          ---          639          677       |   ---          733 (T)      ---          733 (T)   |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.555      P=0.553N     P=0.423      P=0.722    |  P=0.468      P=0.500        (e)        P=0.508    |
|INCIDENTAL TUMOR       |  P=0.636      P=0.471N     P=0.590      P=0.664N   |  P=0.468      P=0.500        (e)        P=0.508    |
|LOGISTIC REGRESSION    |  P=0.554      P=0.536N     P=0.481      P=0.749    |  P=0.468      P=0.500        (e)        P=0.508    |
|COCHRAN-ARMITAGE       |  P=0.558                                           |  P=0.459                                           |
|FISHER EXACT           |               P=0.500N     P=0.500      P=0.753N   |               P=0.500        (e)        P=0.500    |
|=================================================================================================================================|
|                                                                                                                                 |
|Uterus                                                                                                                           |
|     Polyp Stromal                                                                                                               |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |                                                    |  5/50 (10%)   8/50 (16%)   8/50 (16%)   6/50 (12%) |
|ADJUSTED (b)           |                                                    |  18.1%        25.7%        26.5%        19.5%      |
|TERMINAL (d)           |                                                    |  4/25 (16%)   4/25 (16%)   5/26 (19%)   4/26 (15%) |
|FIRST INCIDENCE (DAYS) |                                                    |   634          651          674          532       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |                                                    |  P=0.524N     P=0.293      P=0.294      P=0.511    |
|INCIDENTAL TUMOR       |                                                    |  P=0.554N     P=0.287      P=0.327      P=0.595    |
|LOGISTIC REGRESSION    |                                                    |  P=0.542N     P=0.283      P=0.289      P=0.503    |
|COCHRAN-ARMITAGE       |                                                    |  P=0.530N                                          |
|FISHER EXACT           |                                                    |               P=0.277      P=0.277      P=0.500    |
|=================================================================================================================================|
         DATE: 02/21/96                     EXPERIMENT: 05181 TEST: 03                                                 PAGE  20
                             STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- TETRAHYDROFURAN
                                                 TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   CONTROL      200 PPM      600 PPM      1800 PPM  |   CONTROL      200 PPM      600 PPM      1800 PPM  |
|                       |                                                    |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Uterus                                                                                                                           |
|     Sarcoma Stromal or Polyp Stromal                                                                                            |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |                                                    |  6/50 (12%)   9/50 (18%)   8/50 (16%)   7/50 (14%) |
|ADJUSTED (b)           |                                                    |  20.7%        27.2%        26.5%        21.9%      |
|TERMINAL (d)           |                                                    |  4/25 (16%)   4/25 (16%)   5/26 (19%)   4/26 (15%) |
|FIRST INCIDENCE (DAYS) |                                                    |   634          478          674          532       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |                                                    |  P=0.534N     P=0.307      P=0.399      P=0.498    |
|INCIDENTAL TUMOR       |                                                    |  P=0.561      P=0.307      P=0.447      P=0.541    |
|LOGISTIC REGRESSION    |                                                    |  P=0.535N     P=0.294      P=0.405      P=0.505    |
|COCHRAN-ARMITAGE       |                                                    |  P=0.534N                                          |
|FISHER EXACT           |                                                    |               P=0.288      P=0.387      P=0.500    |
|=================================================================================================================================|
|                                                                                                                                 |
|All Organs                                                                                                                       |
|     Histiocytic Sarcoma                                                                                                         |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #        |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  1/50 (2%)    0/50 (0%)    1/50 (2%)    2/50 (4%)  |  0/50 (0%)    0/50 (0%)    0/50 (0%)    1/50 (2%)  |
|ADJUSTED (b)           |   5.0%         0.0%         5.0%         5.0%      |   0.0%         0.0%         0.0%         3.8%      |
|TERMINAL (d)           |  0/12 (0%)    0/6 (0%)     0/5 (0%)     0/6 (0%)   |  0/25 (0%)    0/25 (0%)    0/26 (0%)    1/26 (4%)  |
|FIRST INCIDENCE (DAYS) |   673          ---          646          511       |   ---          ---          ---          733 (T)   |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.252      P=0.545N     P=0.724      P=0.508    |  P=0.221        (e)          (e)        P=0.508    |
|INCIDENTAL TUMOR       |  P=0.290      P=0.471N     P=0.717N     P=0.571    |  P=0.221        (e)          (e)        P=0.508    |
|LOGISTIC REGRESSION    |  P=0.229      P=0.510N     P=0.761      P=0.483    |  P=0.221        (e)          (e)        P=0.508    |
|COCHRAN-ARMITAGE       |  P=0.235                                           |  P=0.215                                           |
|FISHER EXACT           |               P=0.500N     P=0.753N     P=0.500    |                 (e)          (e)        P=0.500    |
|=================================================================================================================================|
         DATE: 02/21/96                     EXPERIMENT: 05181 TEST: 03                                                 PAGE  21
                             STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- TETRAHYDROFURAN
                                                 TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   CONTROL      200 PPM      600 PPM      1800 PPM  |   CONTROL      200 PPM      600 PPM      1800 PPM  |
|                       |                                                    |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|All Organs                                                                                                                       |
|     Leukemia: Lymphocytic, Monocytic, Mononuclear, or Undifferentiated                                                          |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #        |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            | 30/50 (60%)  29/50 (58%)  27/50 (54%)  32/50 (64%) | 17/50 (34%)  17/50 (34%)  18/50 (36%)  22/50 (44%) |
|ADJUSTED (b)           |  96.1%        90.7%        90.7%        84.6%      |  41.5%        45.3%        51.5%        52.9%      |
|TERMINAL (d)           | 11/12 (92%)   4/6 (67%)    3/5 (60%)    3/6 (50%)  |  4/25 (16%)   7/25 (28%)  10/26 (38%)   8/26 (31%) |
|FIRST INCIDENCE (DAYS) |   422          439          517          431       |   411          467          575          523       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.215      P=0.203      P=0.231      P=0.182    |  P=0.174      P=0.559N     P=0.528      P=0.243    |
|INCIDENTAL TUMOR       |  P=0.349      P=0.580N     P=0.404N     P=0.396    |  P=0.223      P=0.563      P=0.556      P=0.348    |
|LOGISTIC REGRESSION    |  P=0.338      P=0.465N     P=0.283N     P=0.454    |  P=0.199      P=0.581      P=0.507      P=0.294    |
|COCHRAN-ARMITAGE       |  P=0.318                                           |  P=0.142                                           |
|FISHER EXACT           |               P=0.500N     P=0.343N     P=0.418    |               P=0.583N     P=0.500      P=0.206    |
|=================================================================================================================================|
|                                                                                                                                 |
|All Organs                                                                                                                       |
|     Mesothelioma: Benign, Malignant, NOS                                                                                        |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #        |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  2/50 (4%)    2/50 (4%)    1/50 (2%)    1/50 (2%)  |  0/50 (0%)    0/50 (0%)    0/50 (0%)    0/50 (0%)  |
|ADJUSTED (b)           |   9.4%         6.2%         2.4%         3.7%      |   0.0%         0.0%         0.0%         0.0%      |
|TERMINAL (d)           |  0/12 (0%)    0/6 (0%)     0/5 (0%)     0/6 (0%)   |  0/25 (0%)    0/25 (0%)    0/26 (0%)    0/26 (0%)  |
|FIRST INCIDENCE (DAYS) |   621          514          561          644       |   ---          ---          ---          ---       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.401N     P=0.628      P=0.588N     P=0.573N   |    (e)          (e)          (e)          (e)      |
|INCIDENTAL TUMOR       |  P=0.383N     P=0.616N     P=0.393N     P=0.465N   |    (e)          (e)          (e)          (e)      |
|LOGISTIC REGRESSION    |  P=0.385N     P=0.694N     P=0.497N     P=0.503N   |    (e)          (e)          (e)          (e)      |
|COCHRAN-ARMITAGE       |  P=0.383N                                          |    (e)                                             |
|FISHER EXACT           |               P=0.691N     P=0.500N     P=0.500N   |                 (e)          (e)          (e)      |
|=================================================================================================================================|
         DATE: 02/21/96                     EXPERIMENT: 05181 TEST: 03                                                 PAGE  22
                             STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- TETRAHYDROFURAN
                                                 TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   CONTROL      200 PPM      600 PPM      1800 PPM  |   CONTROL      200 PPM      600 PPM      1800 PPM  |
|                       |                                                    |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|All Organs                                                                                                                       |
|     Osteosarcoma                                                                                                                |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #        |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  0/50 (0%)    0/50 (0%)    2/50 (4%)    0/50 (0%)  |  1/50 (2%)    0/50 (0%)    1/50 (2%)    0/50 (0%)  |
|ADJUSTED (b)           |   0.0%         0.0%        14.1%         0.0%      |   4.0%         0.0%         2.7%         0.0%      |
|TERMINAL (d)           |  0/12 (0%)    0/6 (0%)     0/5 (0%)     0/6 (0%)   |  1/25 (4%)    0/25 (0%)    0/26 (0%)    0/26 (0%)  |
|FIRST INCIDENCE (DAYS) |   ---          ---          626          ---       |   733 (T)      ---          660          ---       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.717N       (e)        P=0.184        (e)      |  P=0.466N     P=0.500N     P=0.753N     P=0.492N   |
|INCIDENTAL TUMOR       |  P=0.670N       (e)        P=0.304        (e)      |  P=0.503N     P=0.500N     P=0.747N     P=0.492N   |
|LOGISTIC REGRESSION    |  P=0.696N       (e)        P=0.226        (e)      |  P=0.460N     P=0.500N     P=0.755N     P=0.492N   |
|COCHRAN-ARMITAGE       |  P=0.695N                                          |  P=0.459N                                          |
|FISHER EXACT           |                 (e)        P=0.247        (e)      |               P=0.500N     P=0.753N     P=0.500N   |
|=================================================================================================================================|
|                                                                                                                                 |
|All Organs                                                                                                                       |
|     Osteosarcoma or Osteoma                                                                                                     |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #        |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  0/50 (0%)    0/50 (0%)    2/50 (4%)    0/50 (0%)  |  1/50 (2%)    0/50 (0%)    1/50 (2%)    0/50 (0%)  |
|ADJUSTED (b)           |   0.0%         0.0%        14.1%         0.0%      |   4.0%         0.0%         2.7%         0.0%      |
|TERMINAL (d)           |  0/12 (0%)    0/6 (0%)     0/5 (0%)     0/6 (0%)   |  1/25 (4%)    0/25 (0%)    0/26 (0%)    0/26 (0%)  |
|FIRST INCIDENCE (DAYS) |   ---          ---          626          ---       |   733 (T)      ---          660          ---       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.717N       (e)        P=0.184        (e)      |  P=0.466N     P=0.500N     P=0.753N     P=0.492N   |
|INCIDENTAL TUMOR       |  P=0.670N       (e)        P=0.304        (e)      |  P=0.503N     P=0.500N     P=0.747N     P=0.492N   |
|LOGISTIC REGRESSION    |  P=0.696N       (e)        P=0.226        (e)      |  P=0.460N     P=0.500N     P=0.755N     P=0.492N   |
|COCHRAN-ARMITAGE       |  P=0.695N                                          |  P=0.459N                                          |
|FISHER EXACT           |                 (e)        P=0.247        (e)      |               P=0.500N     P=0.753N     P=0.500N   |
|=================================================================================================================================|
         DATE: 02/21/96                     EXPERIMENT: 05181 TEST: 03                                                 PAGE  23
                             STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- TETRAHYDROFURAN
                                                 TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   CONTROL      200 PPM      600 PPM      1800 PPM  |   CONTROL      200 PPM      600 PPM      1800 PPM  |
|                       |                                                    |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|All Organs                                                                                                                       |
|     Benign Tumors                                                                                                               |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #        |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            | 47/50 (94%)  47/50 (94%)  48/50 (96%)  47/50 (94%) | 42/50 (84%)  45/50 (90%)  48/50 (96%)  43/50 (86%) |
|ADJUSTED (b)           | 100.0%       100.0%       100.0%       100.0%      |  97.6%        95.7%       100.0%        97.7%      |
|TERMINAL (d)           | 12/12 (100%)  6/6 (100%)   5/5 (100%)   6/6 (100%) | 24/25 (96%)  23/25 (92%)  26/26 (100%) 25/26 (96%) |
|FIRST INCIDENCE (DAYS) |   406          439          401          417       |   467          336          519          412       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.306      P=0.136      P=0.094      P=0.183    |  P=0.495N     P=0.417      P=0.286      P=0.509    |
|INCIDENTAL TUMOR       |  P=0.332N     P=0.403N     P=0.692N     P=0.337N   |  P=0.356N     P=0.232      P=0.222      P=0.621N   |
|LOGISTIC REGRESSION    |  P=0.438N     P=0.290N     P=0.639N     P=0.386N   |  P=0.377N     P=0.298      P=0.146      P=0.607    |
|COCHRAN-ARMITAGE       |  P=0.597N                                          |  P=0.513N                                          |
|FISHER EXACT           |               P=0.661N     P=0.500      P=0.661N   |               P=0.277      P=0.046 *    P=0.500    |
|=================================================================================================================================|
|                                                                                                                                 |
|All Organs                                                                                                                       |
|     Malignant Tumors                                                                                                            |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #        |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            | 37/50 (74%)  34/50 (68%)  32/50 (64%)  42/50 (84%) | 27/50 (54%)  25/50 (50%)  23/50 (46%)  30/50 (60%) |
|ADJUSTED (b)           |  97.0%        96.2%        95.9%        94.2%      |  62.6%        64.1%        61.0%        70.2%      |
|TERMINAL (d)           | 11/12 (92%)   5/6 (83%)    4/5 (80%)    4/6 (67%)  | 10/25 (40%)  12/25 (48%)  12/26 (46%)  14/26 (54%) |
|FIRST INCIDENCE (DAYS) |   422          439          517          431       |   411          467          547          498       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.084      P=0.265      P=0.306      P=0.089    |  P=0.258      P=0.422N     P=0.288N     P=0.375    |
|INCIDENTAL TUMOR       |  P=0.091      P=0.325N     P=0.220N     P=0.275    |  P=0.310      P=0.432N     P=0.211N     P=0.531    |
|LOGISTIC REGRESSION    |  P=0.070      P=0.259N     P=0.121N     P=0.204    |  P=0.220      P=0.413N     P=0.249N     P=0.462    |
|COCHRAN-ARMITAGE       |  P=0.063                                           |  P=0.212                                           |
|FISHER EXACT           |               P=0.330N     P=0.194N     P=0.163    |               P=0.421N     P=0.274N     P=0.343    |
|=================================================================================================================================|
         DATE: 02/21/96                     EXPERIMENT: 05181 TEST: 03                                                 PAGE  24
                             STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- TETRAHYDROFURAN
                                                 TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   CONTROL      200 PPM      600 PPM      1800 PPM  |   CONTROL      200 PPM      600 PPM      1800 PPM  |
|                       |                                                    |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|All Organs                                                                                                                       |
|     Malignant and Benign Tumors                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #        |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            | 48/50 (96%)  49/50 (98%)  49/50 (98%)  50/50 (100%)| 46/50 (92%)  47/50 (94%)  49/50 (98%)  48/50 (96%) |
|ADJUSTED (b)           | 100.0%       100.0%       100.0%       100.0%      |  97.8%        97.9%       100.0%        98.0%      |
|TERMINAL (d)           | 12/12 (100%)  6/6 (100%)   5/5 (100%)   6/6 (100%) | 24/25 (96%)  24/25 (96%)  26/26 (100%) 25/26 (96%) |
|FIRST INCIDENCE (DAYS) |   406          439          401          417       |   411          336          519          412       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.243      P=0.118      P=0.099      P=0.137    |  P=0.445      P=0.538      P=0.468      P=0.455    |
|INCIDENTAL TUMOR       |  P=0.563      P=0.571N       (e)          (e)      |  P=0.627N     P=0.486      P=0.477      P=0.681N   |
|LOGISTIC REGRESSION    |  P=0.493      P=0.435N       (e)          (e)      |  P=0.511      P=0.588      P=0.436      P=0.547    |
|COCHRAN-ARMITAGE       |  P=0.193                                           |  P=0.305                                           |
|FISHER EXACT           |               P=0.500      P=0.500      P=0.247    |               P=0.500      P=0.181      P=0.339    |
|=================================================================================================================================|
 (a)  Number of tumor-bearing animals / number of animals examined at site.
 (b)  Kaplan-Meier estimated lifetime tumor incidence after adjustment for 
      intercurrent mortality.
 (d)  Observed incidence at terminal kill.
 (f)  Beneath the control incidence are the P-values associated with the trend 
      test.  Beneath the dosed group incidence are the P-values corresponding to 
      pairwise comparisons between the controls and that dosed group.  The life
      table analysis regards tumors in animals dying  prior to terminal kill as
      being (directly or indirectly) the cause of death.  The incidental tumor 
      test regards these lesions as non-fatal.  Logistic regression is an alternative
      method for analyzing the incidence of non-fatal tumors.  The Cochran-Armitage
      and Fisher's exact tests compare directly the overall incidence rates.  
      For all tests, a negative trend is indicated by "N".
 (e)  Value of Statistic cannot be computed. 
 (I)  Interim sacrifice
 (T)  Terminal sacrifice
  #   Tumor rates based on number of animals necropsied.
  *   To the right of any statistical result, indicates significance at (P<=0.05).
  **  To the right of any statistical result, indicates significance at (P<=0.01).