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https://ntp.niehs.nih.gov/go/2034

TDMS Study 05182-04 Pathology Tables

NTP Experiment-Test: 05182-04         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                          PHENOLPHTHALEIN                                      Date: 04/04/96
Route: DOSED FEED                                                                                                 Time: 03:53:03




       Facility:  TSI Mason Research

       Chemical CAS #:  77-09-8

       Lock Date:  01/24/94

       Cage Range:  All

       Reasons For Removal:    All

       Removal Date Range:     All

       Treatment Groups:       Include All




































a  Number of animals examined microscopically at site and number of animals with lesion

                                                              Page   1


NTP Experiment-Test: 05182-04         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                          PHENOLPHTHALEIN                                      Date: 04/04/96  
Route: DOSED FEED                                                                                                 Time: 03:53:03  
____________________________________________________________________________________________________________________________________

         B6C3F1 MICE FEMALE                        0 PPM        3000 PPM     6000 PPM     12000                                     
                                                                                          PPM                                       
____________________________________________________________________________________________________________________________________

DISPOSITION SUMMARY                                                                                                                 

  Animals Initially In Study                          50           50           50           50                                     
  Early Deaths                                                                                                                      
    Natural Death                                      6            6            7           10                                     
    Moribund Sacrifice                                 5           13            9           12                                     
  Survivors                                                                                                                         
    Terminal Sacrifice                                38           31           34           28                                     
    Moribund Sacrifice                                 1                                                                            

  Animals Examined Microscopically                    50           50           50           50                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Intestine Large, Cecum                             (50)         (48)         (48)         (45)                                   
      Hemorrhage                                                                 1 (2%)                                             
      Epithelium, Hyperplasia                                                                 1 (2%)                                
   Intestine Small, Jejunum                           (49)         (48)         (46)         (46)                                   
      Hemorrhage                                                                 1 (2%)                                             
   Liver                                              (50)         (50)         (50)         (50)                                   
      Angiectasis                                      2 (4%)                                 4 (8%)                                
      Clear Cell Focus                                 1 (2%)       2 (4%)                                                          
      Eosinophilic Focus                              20 (40%)      4 (8%)       2 (4%)       1 (2%)                                
      Fibrosis                                         1 (2%)                                                                       
      Hematopoietic Cell Proliferation                                           2 (4%)       1 (2%)                                
      Inflammation, Chronic                            1 (2%)                    1 (2%)                                             
      Mixed Cell Focus                                 3 (6%)       2 (4%)       1 (2%)                                             
      Necrosis                                         2 (4%)       2 (4%)       1 (2%)       2 (4%)                                
      Vacuolization Cytoplasmic                        3 (6%)                                 2 (4%)                                
      Centrilobular, Necrosis                                                                 1 (2%)                                
      Kupffer Cell, Hyperplasia                        1 (2%)                                                                       
   Mesentery                                          (16)         (2)          (7)          (1)                                    
      Inflammation, Chronic                            1 (6%)                                                                       
      Fat, Congestion                                                            1 (14%)                                            
      Fat, Necrosis                                   14 (88%)      2 (100%)     5 (71%)      1 (100%)                              
   Pancreas                                           (50)         (50)         (50)         (50)                                   
      Cytoplasmic Alteration                                                                  1 (2%)                                
      Inflammation, Acute                                                                     1 (2%)                                
      Inflammation, Chronic                            1 (2%)                                                                       
      Necrosis                                                                                1 (2%)                                
      Acinus, Atrophy                                                                         1 (2%)                                
   Stomach, Forestomach                               (50)         (50)         (50)         (50)                                   
      Edema                                                                      2 (4%)                                             
      Hemorrhage                                                                              1 (2%)                                
      Hyperkeratosis                                                1 (2%)                                                          
      Hyperplasia, Squamous                            3 (6%)       6 (12%)      4 (8%)       2 (4%)                                
      Inflammation, Chronic                                         1 (2%)       1 (2%)                                             

a  Number of animals examined microscopically at site and number of animals with lesion                                             

                                                             Page    2                                                              
NTP Experiment-Test: 05182-04         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                          PHENOLPHTHALEIN                                      Date: 04/04/96  
Route: DOSED FEED                                                                                                 Time: 03:53:03  
____________________________________________________________________________________________________________________________________

         B6C3F1 MICE FEMALE                        0 PPM        3000 PPM     6000 PPM     12000                                     
                                                                                          PPM                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ALIMENTARY SYSTEM - CONT                                                                                                            
      Ulcer                                                         2 (4%)                    3 (6%)                                
      Muscularis, Hyperplasia                          1 (2%)                                                                       
   Stomach, Glandular                                 (50)         (49)         (49)         (50)                                   
      Edema                                                                      2 (4%)                                             
      Erosion                                                       1 (2%)       1 (2%)       3 (6%)                                
      Glands, Hyperplasia                                                        1 (2%)                                             
   Tooth                                                                        (1)                                                 
      Inflammation, Chronic                                                      1 (100%)                                           
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Heart                                              (50)         (50)         (50)         (50)                                   
      Angiectasis                                                   1 (2%)                    1 (2%)                                
      Cardiomyopathy                                   2 (4%)       1 (2%)       2 (4%)       1 (2%)                                
      Hemorrhage                                                                 1 (2%)       1 (2%)                                
      Inflammation, Chronic                            1 (2%)       1 (2%)                                                          
      Inflammation, Chronic Active                                                            1 (2%)                                
      Mineralization                                                5 (10%)      4 (8%)       7 (14%)                               
      Atrium, Thrombosis                                                                      1 (2%)                                
      Valve, Inflammation, Acute                                                 1 (2%)                                             
      Valve, Inflammation, Chronic Active                           1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Cortex                                     (50)         (50)         (50)         (50)                                   
      Angiectasis                                      1 (2%)                                                                       
      Degeneration, Cystic                                                                    1 (2%)                                
      Hematopoietic Cell Proliferation                 1 (2%)                                 1 (2%)                                
      Hypertrophy, Focal                               1 (2%)                                                                       
      Capsule, Hyperplasia                            49 (98%)     50 (100%)    50 (100%)    49 (98%)                               
   Adrenal Medulla                                    (50)         (50)         (50)         (50)                                   
      Hyperplasia                                      2 (4%)                                                                       
   Islets, Pancreatic                                 (49)         (50)         (50)         (50)                                   
      Hyperplasia                                     32 (65%)     32 (64%)     37 (74%)     26 (52%)                               
   Parathyroid Gland                                  (46)         (48)         (47)         (47)                                   
      Cyst                                             1 (2%)                                                                       
      Hyperplasia                                                                1 (2%)                                             
   Pituitary Gland                                    (49)         (50)         (49)         (48)                                   
      Pars Distalis, Angiectasis                                    1 (2%)                                                          
      Pars Distalis, Cyst                                           1 (2%)                    1 (2%)                                
      Pars Distalis, Hyperplasia                      11 (22%)      4 (8%)       1 (2%)       1 (2%)                                
      Rathke's Cleft, Cyst                             1 (2%)                                                                       
   Thyroid Gland                                      (50)         (50)         (50)         (50)                                   
      Cyst                                             1 (2%)                                                                       
      Inflammation, Chronic                            1 (2%)                                                                       

a  Number of animals examined microscopically at site and number of animals with lesion                                             

                                                             Page    3                                                              
NTP Experiment-Test: 05182-04         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                          PHENOLPHTHALEIN                                      Date: 04/04/96  
Route: DOSED FEED                                                                                                 Time: 03:53:03  
____________________________________________________________________________________________________________________________________

         B6C3F1 MICE FEMALE                        0 PPM        3000 PPM     6000 PPM     12000                                     
                                                                                          PPM                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ENDOCRINE SYSTEM - CONT                                                                                                             
      Follicular Cell, Hyperplasia                    27 (54%)      8 (16%)      3 (6%)       7 (14%)                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Clitoral Gland                                     (48)         (48)         (48)         (50)                                   
      Cyst                                             2 (4%)       2 (4%)                    1 (2%)                                
      Inflammation, Chronic Active                                               1 (2%)                                             
      Pigmentation                                     2 (4%)       3 (6%)                    1 (2%)                                
   Ovary                                              (50)         (49)         (50)         (50)                                   
      Angiectasis                                      1 (2%)                    1 (2%)                                             
      Cyst                                            15 (30%)      8 (16%)     16 (32%)     12 (24%)                               
      Hemorrhage                                       3 (6%)       1 (2%)       3 (6%)       2 (4%)                                
      Hyperplasia                                      3 (6%)      10 (20%)     10 (20%)     17 (34%)                               
      Hyperplasia, Papillary                           1 (2%)       1 (2%)                                                          
      Inflammation, Chronic                            1 (2%)                                                                       
      Necrosis                                                      1 (2%)                                                          
      Thrombosis                                                                              1 (2%)                                
      Periovarian Tissue, Necrosis                                                            1 (2%)                                
   Uterus                                             (50)         (50)         (50)         (50)                                   
      Angiectasis                                      3 (6%)                                                                       
      Hemorrhage                                                                 1 (2%)                                             
      Hyperplasia, Cystic                             49 (98%)     46 (92%)     43 (86%)     45 (90%)                               
      Inflammation, Chronic Active                     1 (2%)                                                                       
      Necrosis                                                                                1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (50)         (50)         (50)         (50)                                   
      Hyperplasia, Reticulum Cell                                   1 (2%)       1 (2%)                                             
      Myelofibrosis                                   34 (68%)     34 (68%)     38 (76%)     36 (72%)                               
      Pigmentation                                     2 (4%)       3 (6%)      11 (22%)     11 (22%)                               
   Lymph Node                                         (14)         (17)         (13)         (16)                                   
      Iliac, Hyperplasia, Lymphoid                     2 (14%)                                                                      
      Mediastinal, Hyperplasia, Lymphoid               1 (7%)                                                                       
      Mediastinal, Infiltration Cellular,                                                                                           
          Histiocyte                                   1 (7%)                                                                       
      Mediastinal, Pigmentation                        1 (7%)                                                                       
      Renal, Infiltration Cellular, Histiocyte         1 (7%)                                                                       
      Renal, Pigmentation                              1 (7%)                                                                       
   Lymph Node, Mandibular                             (49)         (50)         (49)         (49)                                   

a  Number of animals examined microscopically at site and number of animals with lesion                                             

                                                             Page    4                                                              
NTP Experiment-Test: 05182-04         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                          PHENOLPHTHALEIN                                      Date: 04/04/96  
Route: DOSED FEED                                                                                                 Time: 03:53:03  
____________________________________________________________________________________________________________________________________

         B6C3F1 MICE FEMALE                        0 PPM        3000 PPM     6000 PPM     12000                                     
                                                                                          PPM                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
HEMATOPOIETIC SYSTEM - CONT                                                                                                         
      Atrophy                                                                                 1 (2%)                                
      Hematopoietic Cell Proliferation                 1 (2%)                                                                       
      Hyperplasia, Lymphoid                                         1 (2%)       1 (2%)                                             
   Lymph Node, Mesenteric                             (49)         (50)         (49)         (50)                                   
      Angiectasis                                      1 (2%)       2 (4%)       3 (6%)       2 (4%)                                
      Atrophy                                                                                 1 (2%)                                
      Hematopoietic Cell Proliferation                 1 (2%)                                                                       
      Hemorrhage                                       1 (2%)                                                                       
      Hyperplasia, Lymphoid                            1 (2%)                    1 (2%)                                             
   Spleen                                             (50)         (50)         (50)         (50)                                   
      Fibrosis                                         1 (2%)                                                                       
      Hematopoietic Cell Proliferation                13 (26%)     14 (28%)     20 (40%)     21 (42%)                               
      Pigmentation                                     4 (8%)       1 (2%)       2 (4%)       3 (6%)                                
      Lymphoid Follicle, Atrophy                                    1 (2%)                    1 (2%)                                
      Lymphoid Follicle, Hyperplasia                   6 (12%)      5 (10%)      3 (6%)                                             
   Thymus                                             (48)         (44)         (49)         (45)                                   
      Atrophy                                          3 (6%)       1 (2%)       6 (12%)      9 (20%)                               
      Fibrosis                                         1 (2%)                                                                       
      Hyperplasia, Atypical                                         7 (16%)      6 (12%)      5 (11%)                               
      Infiltration Cellular, Polymorphonuclear         2 (4%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Skin                                               (50)         (50)         (50)         (50)                                   
      Inflammation, Chronic                                         2 (4%)                                                          
      Ulcer                                                                                   1 (2%)                                
      Subcutaneous Tissue, Edema                                                 3 (6%)       3 (6%)                                
      Subcutaneous Tissue, Inflammation, Chronic                                              1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (50)         (49)         (50)         (50)                                   
      Demyelination                                                                           1 (2%)                                
      Hemorrhage                                                                              2 (4%)                                
      Thalamus, Mineralization                        28 (56%)     23 (47%)     24 (48%)     24 (48%)                               
   Peripheral Nerve                                   (1)                       (1)                                                 
      Demyelination                                    1 (100%)                                                                     
   Spinal Cord                                        (1)                       (1)                                                 
      Demyelination                                    1 (100%)                                                                     
____________________________________________________________________________________________________________________________________

a  Number of animals examined microscopically at site and number of animals with lesion                                             

                                                             Page    5                                                              
NTP Experiment-Test: 05182-04         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                          PHENOLPHTHALEIN                                      Date: 04/04/96  
Route: DOSED FEED                                                                                                 Time: 03:53:03  
____________________________________________________________________________________________________________________________________

         B6C3F1 MICE FEMALE                        0 PPM        3000 PPM     6000 PPM     12000                                     
                                                                                          PPM                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (50)         (50)         (50)         (50)                                   
      Hemorrhage                                       7 (14%)      4 (8%)       6 (12%)      4 (8%)                                
      Infiltration Cellular, Histiocyte                2 (4%)       3 (6%)                                                          
      Thrombosis                                       1 (2%)                                                                       
      Alveolar Epithelium, Hyperplasia                 1 (2%)                    1 (2%)       1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (50)         (50)         (50)         (50)                                   
      Cyst                                                          1 (2%)                    1 (2%)                                
      Hydronephrosis                                   1 (2%)       1 (2%)                    1 (2%)                                
      Infarct                                                       1 (2%)                                                          
      Inflammation, Chronic                            1 (2%)                                                                       
      Mineralization                                                             1 (2%)                                             
      Necrosis                                                                   1 (2%)       1 (2%)                                
      Nephropathy, Chronic                            15 (30%)     16 (32%)     19 (38%)     14 (28%)                               
      Pigmentation                                     1 (2%)                                                                       
      Pelvis, Hemorrhage                                                                      1 (2%)                                
      Renal Tubule, Accumulation, Hyaline Droplet                   1 (2%)       3 (6%)       8 (16%)                               
      Renal Tubule, Dilatation                                                                2 (4%)                                
   Urinary Bladder                                    (50)         (50)         (49)         (50)                                   
      Hyperplasia, Lymphoid                                         1 (2%)                                                          
      Infiltration Cellular, Lymphocyte                                          1 (2%)                                             
                                                                                                                                    

a  Number of animals examined microscopically at site and number of animals with lesion                                             

                                                             Page    6                                                              
NTP Experiment-Test: 05182-04         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                          PHENOLPHTHALEIN                                      Date: 04/04/96  
Route: DOSED FEED                                                                                                 Time: 03:53:03  
____________________________________________________________________________________________________________________________________

         B6C3F1 MICE MALE                          0 PPM        3000 PPM     6000 PPM     12000                                     
                                                                                          PPM                                       
____________________________________________________________________________________________________________________________________

DISPOSITION SUMMARY                                                                                                                 

  Animals Initially In Study                          50           50           50           50                                     
  Early Deaths                                                                                                                      
    Moribund Sacrifice                                 6           13           11            3                                     
    Natural Death                                      4            4            3           10                                     
  Survivors                                                                                                                         
    Terminal Sacrifice                                40           33           36           36                                     
  Missing                                                                                     1                                     

  Animals Examined Microscopically                    50           50           50           49                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Gallbladder                                        (50)         (46)         (46)         (41)                                   
      Metaplasia                                       1 (2%)                                                                       
   Intestine Large, Rectum                            (50)         (50)         (50)         (48)                                   
      Edema                                                                      1 (2%)                                             
   Intestine Large, Cecum                             (50)         (48)         (47)         (45)                                   
      Edema                                                         1 (2%)                                                          
      Serosa, Inflammation, Chronic                                 1 (2%)                                                          
   Intestine Small, Jejunum                           (49)         (49)         (48)         (46)                                   
      Hemorrhage                                       1 (2%)                                                                       
      Necrosis                                         1 (2%)                                                                       
   Liver                                              (50)         (50)         (50)         (49)                                   
      Angiectasis                                                   1 (2%)                    1 (2%)                                
      Clear Cell Focus                                24 (48%)      6 (12%)      1 (2%)                                             
      Congestion                                                    2 (4%)                                                          
      Eosinophilic Focus                              22 (44%)      6 (12%)      1 (2%)       1 (2%)                                
      Fibrosis                                         1 (2%)                                                                       
      Hematopoietic Cell Proliferation                              6 (12%)      6 (12%)      2 (4%)                                
      Inflammation, Chronic                            4 (8%)       3 (6%)       7 (14%)      5 (10%)                               
      Mineralization                                                             1 (2%)       1 (2%)                                
      Mixed Cell Focus                                 6 (12%)      2 (4%)       1 (2%)                                             
      Necrosis                                         4 (8%)       4 (8%)       4 (8%)       2 (4%)                                
      Vacuolization Cytoplasmic                        7 (14%)      4 (8%)       2 (4%)       4 (8%)                                
      Bile Duct, Cyst                                  1 (2%)                                 1 (2%)                                
      Bile Duct, Inflammation, Suppurative             1 (2%)                                                                       
      Oval Cell, Hyperplasia                           4 (8%)       2 (4%)                    1 (2%)                                
   Mesentery                                          (9)          (9)          (4)          (3)                                    
      Inflammation, Chronic Active                                  1 (11%)                                                         
      Fat, Necrosis                                    7 (78%)      3 (33%)      2 (50%)      2 (67%)                               
   Pancreas                                           (50)         (50)         (50)         (49)                                   
      Inflammation, Chronic                                         1 (2%)                                                          
      Acinus, Atrophy                                  1 (2%)       1 (2%)       1 (2%)       4 (8%)                                
      Duct, Cyst                                                    1 (2%)                                                          
   Salivary Glands                                    (50)         (50)         (50)         (49)                                   

a  Number of animals examined microscopically at site and number of animals with lesion                                             

                                                             Page    7                                                              
NTP Experiment-Test: 05182-04         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                          PHENOLPHTHALEIN                                      Date: 04/04/96  
Route: DOSED FEED                                                                                                 Time: 03:53:03  
____________________________________________________________________________________________________________________________________

         B6C3F1 MICE MALE                          0 PPM        3000 PPM     6000 PPM     12000                                     
                                                                                          PPM                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ALIMENTARY SYSTEM - CONT                                                                                                            
      Inflammation, Chronic                                                                   1 (2%)                                
      Necrosis                                                      1 (2%)                                                          
      Duct, Cyst                                                                 1 (2%)                                             
   Stomach, Forestomach                               (50)         (50)         (50)         (49)                                   
      Hyperkeratosis                                   1 (2%)                                                                       
      Hyperplasia, Squamous                            4 (8%)       7 (14%)      8 (16%)      4 (8%)                                
      Inflammation, Chronic                                         2 (4%)       1 (2%)                                             
      Mineralization                                   1 (2%)                                                                       
      Ulcer                                            1 (2%)       3 (6%)       3 (6%)       1 (2%)                                
      Serosa, Inflammation, Chronic                                 1 (2%)                                                          
   Stomach, Glandular                                 (50)         (50)         (50)         (48)                                   
      Cyst                                                                       1 (2%)                                             
      Erosion                                                       1 (2%)       2 (4%)       5 (10%)                               
      Mineralization                                   1 (2%)                                                                       
      Glands, Atrophy, Focal                                                     1 (2%)                                             
      Glands, Cyst                                     1 (2%)                                                                       
      Glands, Hyperplasia                              1 (2%)       1 (2%)       1 (2%)       2 (4%)                                
      Serosa, Inflammation, Chronic                                 1 (2%)                                                          
   Tooth                                              (49)         (50)         (50)         (49)                                   
      Degeneration                                    22 (45%)     12 (24%)      4 (8%)       1 (2%)                                
      Inflammation, Chronic                                         1 (2%)                                                          
      Inflammation, Chronic Active                                  1 (2%)       1 (2%)       2 (4%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Heart                                              (50)         (50)         (50)         (49)                                   
      Cardiomyopathy                                   1 (2%)       1 (2%)       2 (4%)       5 (10%)                               
      Inflammation, Chronic                                                      1 (2%)                                             
      Inflammation, Chronic Active                                  1 (2%)                                                          
      Mineralization                                                1 (2%)       2 (4%)       1 (2%)                                
      Myocardium, Degeneration                                                                1 (2%)                                
      Valve, Inflammation                                                                     1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Cortex                                     (49)         (50)         (49)         (48)                                   
      Hemorrhage                                                                              1 (2%)                                
      Hyperplasia                                      1 (2%)       1 (2%)                                                          
      Hypertrophy, Focal                              16 (33%)     14 (28%)     10 (20%)     11 (23%)                               
      Capsule, Hyperplasia                            36 (73%)     37 (74%)     34 (69%)     34 (71%)                               
      Capsule, Inflammation, Chronic                                1 (2%)                                                          
   Adrenal Medulla                                    (49)         (50)         (49)         (48)                                   
      Hyperplasia                                      1 (2%)                    1 (2%)                                             
   Islets, Pancreatic                                 (50)         (50)         (50)         (49)                                   
      Hyperplasia                                     45 (90%)     45 (90%)     44 (88%)     41 (84%)                               

a  Number of animals examined microscopically at site and number of animals with lesion                                             

                                                             Page    8                                                              
NTP Experiment-Test: 05182-04         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                          PHENOLPHTHALEIN                                      Date: 04/04/96  
Route: DOSED FEED                                                                                                 Time: 03:53:03  
____________________________________________________________________________________________________________________________________

         B6C3F1 MICE MALE                          0 PPM        3000 PPM     6000 PPM     12000                                     
                                                                                          PPM                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ENDOCRINE SYSTEM - CONT                                                                                                             
   Parathyroid Gland                                  (46)         (48)         (48)         (45)                                   
      Cyst                                                                       2 (4%)                                             
   Pituitary Gland                                    (48)         (50)         (49)         (48)                                   
      Pars Distalis, Cyst                              2 (4%)       1 (2%)       3 (6%)       2 (4%)                                
      Pars Distalis, Hyperplasia                                    1 (2%)       1 (2%)                                             
   Thyroid Gland                                      (49)         (50)         (50)         (49)                                   
      Cyst                                                                                    1 (2%)                                
      Follicular Cell, Hyperplasia                     5 (10%)      4 (8%)                    1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Epididymis                                         (50)         (50)         (50)         (49)                                   
      Granuloma Sperm                                                                         1 (2%)                                
      Inflammation, Chronic                                         1 (2%)                                                          
      Inflammation, Granulomatous                                   1 (2%)                                                          
      Spermatocele                                     1 (2%)       1 (2%)                                                          
   Penis                                              (1)                                                                           
      Hemorrhage                                       1 (100%)                                                                     
   Preputial Gland                                    (49)         (50)         (49)         (49)                                   
      Cyst                                            39 (80%)     37 (74%)     41 (84%)     47 (96%)                               
      Granuloma                                                                  1 (2%)                                             
      Hyperplasia, Lymphoid                                                      1 (2%)                                             
      Inflammation, Acute                                           1 (2%)                                                          
      Inflammation, Chronic                            5 (10%)      1 (2%)       3 (6%)       3 (6%)                                
      Inflammation, Chronic Active                     1 (2%)       2 (4%)       5 (10%)      7 (14%)                               
   Prostate                                           (50)         (50)         (50)         (49)                                   
      Cyst                                                          1 (2%)                                                          
      Inflammation, Chronic                                         1 (2%)                                                          
   Seminal Vesicle                                    (50)         (50)         (50)         (49)                                   
      Atrophy                                                                                 1 (2%)                                
      Hypertrophy                                      1 (2%)                                                                       
   Testes                                             (50)         (50)         (50)         (48)                                   
      Germinal Epithelium, Degeneration                1 (2%)      49 (98%)     50 (100%)    47 (98%)                               
      Interstitial Cell, Hyperplasia                                1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    

a  Number of animals examined microscopically at site and number of animals with lesion                                             

                                                             Page    9                                                              
NTP Experiment-Test: 05182-04         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                          PHENOLPHTHALEIN                                      Date: 04/04/96  
Route: DOSED FEED                                                                                                 Time: 03:53:03  
____________________________________________________________________________________________________________________________________

         B6C3F1 MICE MALE                          0 PPM        3000 PPM     6000 PPM     12000                                     
                                                                                          PPM                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (50)         (50)         (50)         (49)                                   
      Angiectasis                                                                2 (4%)                                             
      Myelofibrosis                                    3 (6%)       8 (16%)      8 (16%)     19 (39%)                               
      Pigmentation                                                  2 (4%)       5 (10%)     16 (33%)                               
      Thrombosis                                                    2 (4%)                                                          
      Myeloid Cell, Hyperplasia                                     1 (2%)                                                          
   Lymph Node                                         (8)          (5)          (14)         (9)                                    
      Iliac, Angiectasis                                                         1 (7%)                                             
      Iliac, Hyperplasia                                                                      1 (11%)                               
      Iliac, Hyperplasia, Lymphoid                     1 (13%)                   2 (14%)                                            
      Iliac, Pigmentation                              1 (13%)                                                                      
      Inguinal, Hyperplasia, Lymphoid                  3 (38%)                   2 (14%)      1 (11%)                               
      Inguinal, Pigmentation                                                     1 (7%)                                             
      Mediastinal, Hyperplasia, Lymphoid               1 (13%)                   1 (7%)                                             
      Mediastinal, Infiltration Cellular, Plasma                                                                                    
          Cell                                                                                1 (11%)                               
      Pancreatic, Angiectasis                          1 (13%)                   1 (7%)                                             
      Renal, Angiectasis                                                         1 (7%)                                             
      Renal, Hyperplasia, Lymphoid                                                            1 (11%)                               
   Lymph Node, Mandibular                             (49)         (50)         (49)         (49)                                   
      Angiectasis                                                                             1 (2%)                                
      Hyperplasia, Lymphoid                            2 (4%)       1 (2%)       2 (4%)       1 (2%)                                
      Infiltration Cellular, Histiocyte                                                       1 (2%)                                
   Lymph Node, Mesenteric                             (50)         (50)         (48)         (49)                                   
      Angiectasis                                     11 (22%)     10 (20%)     13 (27%)     12 (24%)                               
      Hyperplasia, Lymphoid                            3 (6%)       2 (4%)                    3 (6%)                                
      Infiltration Cellular, Polymorphonuclear         2 (4%)                                                                       
      Infiltration Cellular, Histiocyte                                          1 (2%)                                             
      Inflammation, Chronic                                         1 (2%)                                                          
   Spleen                                             (50)         (50)         (50)         (49)                                   
      Angiectasis                                                   1 (2%)                                                          
      Hematopoietic Cell Proliferation                10 (20%)     22 (44%)     28 (56%)     21 (43%)                               
      Pigmentation                                     3 (6%)       5 (10%)                   4 (8%)                                
      Lymphoid Follicle, Atrophy                       1 (2%)                                                                       
      Lymphoid Follicle, Hyperplasia                   2 (4%)       2 (4%)       4 (8%)                                             
      Lymphoid Follicle, Necrosis                      1 (2%)                                                                       
   Thymus                                             (43)         (46)         (44)         (42)                                   
      Atrophy                                         13 (30%)     11 (24%)     16 (36%)     12 (29%)                               
      Cyst                                                          1 (2%)                                                          
      Hyperplasia, Atypical                                         3 (7%)       7 (16%)      7 (17%)                               
      Hyperplasia, Oncocytic                           1 (2%)                                                                       
      Necrosis                                         1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    

a  Number of animals examined microscopically at site and number of animals with lesion                                             

                                                             Page   10                                                              
NTP Experiment-Test: 05182-04         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                          PHENOLPHTHALEIN                                      Date: 04/04/96  
Route: DOSED FEED                                                                                                 Time: 03:53:03  
____________________________________________________________________________________________________________________________________

         B6C3F1 MICE MALE                          0 PPM        3000 PPM     6000 PPM     12000                                     
                                                                                          PPM                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Skin                                               (50)         (50)         (50)         (49)                                   
      Inflammation, Acute                                                        1 (2%)       1 (2%)                                
      Inflammation, Chronic                                         2 (4%)                    1 (2%)                                
      Subcutaneous Tissue, Edema                                    2 (4%)       7 (14%)      6 (12%)                               
      Subcutaneous Tissue, Infiltration Cellular,                                                                                   
           Polymorphonuclear                                                                  1 (2%)                                
      Subcutaneous Tissue, Inflammation, Acute                                   1 (2%)       1 (2%)                                
      Subcutaneous Tissue, Inflammation, Chronic                                              1 (2%)                                
      Subcutaneous Tissue, Necrosis                                 1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (50)         (50)         (50)         (49)                                   
      Hemorrhage                                                    1 (2%)                    1 (2%)                                
      Necrosis                                         1 (2%)                                                                       
      Thalamus, Mineralization                        27 (54%)     24 (48%)     25 (50%)     35 (71%)                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (50)         (50)         (50)         (49)                                   
      Congestion                                       1 (2%)       2 (4%)       1 (2%)       1 (2%)                                
      Hemorrhage                                       1 (2%)       3 (6%)       4 (8%)       7 (14%)                               
      Infiltration Cellular, Histiocyte                5 (10%)      5 (10%)      2 (4%)                                             
      Inflammation, Granulomatous                      1 (2%)                                                                       
      Alveolar Epithelium, Hyperplasia                 3 (6%)       5 (10%)      3 (6%)       3 (6%)                                
   Nose                                               (50)         (50)         (50)         (49)                                   
      Inflammation, Acute                              2 (4%)                                                                       
      Polyp, Inflammatory                              1 (2%)       1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Harderian Gland                                    (3)          (4)          (4)          (3)                                    
      Hypertrophy                                                   1 (25%)                   2 (67%)                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    

a  Number of animals examined microscopically at site and number of animals with lesion                                             

                                                             Page   11                                                              
NTP Experiment-Test: 05182-04         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                          PHENOLPHTHALEIN                                      Date: 04/04/96  
Route: DOSED FEED                                                                                                 Time: 03:53:03  
____________________________________________________________________________________________________________________________________

         B6C3F1 MICE MALE                          0 PPM        3000 PPM     6000 PPM     12000                                     
                                                                                          PPM                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (50)         (50)         (50)         (49)                                   
      Cyst                                             7 (14%)      5 (10%)      5 (10%)      4 (8%)                                
      Hydronephrosis                                   2 (4%)                                                                       
      Infarct                                                                                 1 (2%)                                
      Infarct, Chronic                                                                        1 (2%)                                
      Inflammation, Acute                                                                     1 (2%)                                
      Metaplasia, Osseous                              1 (2%)                                                                       
      Mineralization                                   7 (14%)      1 (2%)       2 (4%)                                             
      Nephropathy, Chronic                            47 (94%)     46 (92%)     42 (84%)     41 (84%)                               
      Pigmentation                                                               1 (2%)                                             
      Papilla, Necrosis                                1 (2%)                                                                       
      Pelvis, Angiectasis                              1 (2%)                                                                       
      Renal Tubule, Accumulation, Hyaline Droplet                   2 (4%)       5 (10%)      5 (10%)                               
      Renal Tubule, Dilatation                         1 (2%)                    1 (2%)       2 (4%)                                
      Renal Tubule, Hyperplasia                        1 (2%)                                                                       
      Renal Tubule, Necrosis                                                                  1 (2%)                                
      Transitional Epithelium, Hyperplasia                                       1 (2%)                                             
   Urinary Bladder                                    (50)         (50)         (48)         (49)                                   
      Hemorrhage                                                    1 (2%)                                                          
      Inflammation, Acute                                                                     1 (2%)                                
      Serosa, Inflammation, Chronic                                 1 (2%)                                                          
                                                                                                                                    

a  Number of animals examined microscopically at site and number of animals with lesion                                             

                                                             Page   12                                                              
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