TDMS Study 05182-04 Pathology Tables
NTP Experiment-Test: 05182-04 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC PHENOLPHTHALEIN Date: 04/04/96
Route: DOSED FEED Time: 03:53:03
Facility: TSI Mason Research
Chemical CAS #: 77-09-8
Lock Date: 01/24/94
Cage Range: All
Reasons For Removal: All
Removal Date Range: All
Treatment Groups: Include All
a Number of animals examined microscopically at site and number of animals with lesion
Page 1
NTP Experiment-Test: 05182-04 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC PHENOLPHTHALEIN Date: 04/04/96
Route: DOSED FEED Time: 03:53:03
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE 0 PPM 3000 PPM 6000 PPM 12000
PPM
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially In Study 50 50 50 50
Early Deaths
Natural Death 6 6 7 10
Moribund Sacrifice 5 13 9 12
Survivors
Terminal Sacrifice 38 31 34 28
Moribund Sacrifice 1
Animals Examined Microscopically 50 50 50 50
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Intestine Large, Cecum (50) (48) (48) (45)
Hemorrhage 1 (2%)
Epithelium, Hyperplasia 1 (2%)
Intestine Small, Jejunum (49) (48) (46) (46)
Hemorrhage 1 (2%)
Liver (50) (50) (50) (50)
Angiectasis 2 (4%) 4 (8%)
Clear Cell Focus 1 (2%) 2 (4%)
Eosinophilic Focus 20 (40%) 4 (8%) 2 (4%) 1 (2%)
Fibrosis 1 (2%)
Hematopoietic Cell Proliferation 2 (4%) 1 (2%)
Inflammation, Chronic 1 (2%) 1 (2%)
Mixed Cell Focus 3 (6%) 2 (4%) 1 (2%)
Necrosis 2 (4%) 2 (4%) 1 (2%) 2 (4%)
Vacuolization Cytoplasmic 3 (6%) 2 (4%)
Centrilobular, Necrosis 1 (2%)
Kupffer Cell, Hyperplasia 1 (2%)
Mesentery (16) (2) (7) (1)
Inflammation, Chronic 1 (6%)
Fat, Congestion 1 (14%)
Fat, Necrosis 14 (88%) 2 (100%) 5 (71%) 1 (100%)
Pancreas (50) (50) (50) (50)
Cytoplasmic Alteration 1 (2%)
Inflammation, Acute 1 (2%)
Inflammation, Chronic 1 (2%)
Necrosis 1 (2%)
Acinus, Atrophy 1 (2%)
Stomach, Forestomach (50) (50) (50) (50)
Edema 2 (4%)
Hemorrhage 1 (2%)
Hyperkeratosis 1 (2%)
Hyperplasia, Squamous 3 (6%) 6 (12%) 4 (8%) 2 (4%)
Inflammation, Chronic 1 (2%) 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 2
NTP Experiment-Test: 05182-04 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC PHENOLPHTHALEIN Date: 04/04/96
Route: DOSED FEED Time: 03:53:03
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE 0 PPM 3000 PPM 6000 PPM 12000
PPM
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - CONT
Ulcer 2 (4%) 3 (6%)
Muscularis, Hyperplasia 1 (2%)
Stomach, Glandular (50) (49) (49) (50)
Edema 2 (4%)
Erosion 1 (2%) 1 (2%) 3 (6%)
Glands, Hyperplasia 1 (2%)
Tooth (1)
Inflammation, Chronic 1 (100%)
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Heart (50) (50) (50) (50)
Angiectasis 1 (2%) 1 (2%)
Cardiomyopathy 2 (4%) 1 (2%) 2 (4%) 1 (2%)
Hemorrhage 1 (2%) 1 (2%)
Inflammation, Chronic 1 (2%) 1 (2%)
Inflammation, Chronic Active 1 (2%)
Mineralization 5 (10%) 4 (8%) 7 (14%)
Atrium, Thrombosis 1 (2%)
Valve, Inflammation, Acute 1 (2%)
Valve, Inflammation, Chronic Active 1 (2%)
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Cortex (50) (50) (50) (50)
Angiectasis 1 (2%)
Degeneration, Cystic 1 (2%)
Hematopoietic Cell Proliferation 1 (2%) 1 (2%)
Hypertrophy, Focal 1 (2%)
Capsule, Hyperplasia 49 (98%) 50 (100%) 50 (100%) 49 (98%)
Adrenal Medulla (50) (50) (50) (50)
Hyperplasia 2 (4%)
Islets, Pancreatic (49) (50) (50) (50)
Hyperplasia 32 (65%) 32 (64%) 37 (74%) 26 (52%)
Parathyroid Gland (46) (48) (47) (47)
Cyst 1 (2%)
Hyperplasia 1 (2%)
Pituitary Gland (49) (50) (49) (48)
Pars Distalis, Angiectasis 1 (2%)
Pars Distalis, Cyst 1 (2%) 1 (2%)
Pars Distalis, Hyperplasia 11 (22%) 4 (8%) 1 (2%) 1 (2%)
Rathke's Cleft, Cyst 1 (2%)
Thyroid Gland (50) (50) (50) (50)
Cyst 1 (2%)
Inflammation, Chronic 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 3
NTP Experiment-Test: 05182-04 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC PHENOLPHTHALEIN Date: 04/04/96
Route: DOSED FEED Time: 03:53:03
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE 0 PPM 3000 PPM 6000 PPM 12000
PPM
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - CONT
Follicular Cell, Hyperplasia 27 (54%) 8 (16%) 3 (6%) 7 (14%)
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
None
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Clitoral Gland (48) (48) (48) (50)
Cyst 2 (4%) 2 (4%) 1 (2%)
Inflammation, Chronic Active 1 (2%)
Pigmentation 2 (4%) 3 (6%) 1 (2%)
Ovary (50) (49) (50) (50)
Angiectasis 1 (2%) 1 (2%)
Cyst 15 (30%) 8 (16%) 16 (32%) 12 (24%)
Hemorrhage 3 (6%) 1 (2%) 3 (6%) 2 (4%)
Hyperplasia 3 (6%) 10 (20%) 10 (20%) 17 (34%)
Hyperplasia, Papillary 1 (2%) 1 (2%)
Inflammation, Chronic 1 (2%)
Necrosis 1 (2%)
Thrombosis 1 (2%)
Periovarian Tissue, Necrosis 1 (2%)
Uterus (50) (50) (50) (50)
Angiectasis 3 (6%)
Hemorrhage 1 (2%)
Hyperplasia, Cystic 49 (98%) 46 (92%) 43 (86%) 45 (90%)
Inflammation, Chronic Active 1 (2%)
Necrosis 1 (2%)
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Bone Marrow (50) (50) (50) (50)
Hyperplasia, Reticulum Cell 1 (2%) 1 (2%)
Myelofibrosis 34 (68%) 34 (68%) 38 (76%) 36 (72%)
Pigmentation 2 (4%) 3 (6%) 11 (22%) 11 (22%)
Lymph Node (14) (17) (13) (16)
Iliac, Hyperplasia, Lymphoid 2 (14%)
Mediastinal, Hyperplasia, Lymphoid 1 (7%)
Mediastinal, Infiltration Cellular,
Histiocyte 1 (7%)
Mediastinal, Pigmentation 1 (7%)
Renal, Infiltration Cellular, Histiocyte 1 (7%)
Renal, Pigmentation 1 (7%)
Lymph Node, Mandibular (49) (50) (49) (49)
a Number of animals examined microscopically at site and number of animals with lesion
Page 4
NTP Experiment-Test: 05182-04 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC PHENOLPHTHALEIN Date: 04/04/96
Route: DOSED FEED Time: 03:53:03
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE 0 PPM 3000 PPM 6000 PPM 12000
PPM
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - CONT
Atrophy 1 (2%)
Hematopoietic Cell Proliferation 1 (2%)
Hyperplasia, Lymphoid 1 (2%) 1 (2%)
Lymph Node, Mesenteric (49) (50) (49) (50)
Angiectasis 1 (2%) 2 (4%) 3 (6%) 2 (4%)
Atrophy 1 (2%)
Hematopoietic Cell Proliferation 1 (2%)
Hemorrhage 1 (2%)
Hyperplasia, Lymphoid 1 (2%) 1 (2%)
Spleen (50) (50) (50) (50)
Fibrosis 1 (2%)
Hematopoietic Cell Proliferation 13 (26%) 14 (28%) 20 (40%) 21 (42%)
Pigmentation 4 (8%) 1 (2%) 2 (4%) 3 (6%)
Lymphoid Follicle, Atrophy 1 (2%) 1 (2%)
Lymphoid Follicle, Hyperplasia 6 (12%) 5 (10%) 3 (6%)
Thymus (48) (44) (49) (45)
Atrophy 3 (6%) 1 (2%) 6 (12%) 9 (20%)
Fibrosis 1 (2%)
Hyperplasia, Atypical 7 (16%) 6 (12%) 5 (11%)
Infiltration Cellular, Polymorphonuclear 2 (4%)
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Skin (50) (50) (50) (50)
Inflammation, Chronic 2 (4%)
Ulcer 1 (2%)
Subcutaneous Tissue, Edema 3 (6%) 3 (6%)
Subcutaneous Tissue, Inflammation, Chronic 1 (2%)
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
None
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
Brain (50) (49) (50) (50)
Demyelination 1 (2%)
Hemorrhage 2 (4%)
Thalamus, Mineralization 28 (56%) 23 (47%) 24 (48%) 24 (48%)
Peripheral Nerve (1) (1)
Demyelination 1 (100%)
Spinal Cord (1) (1)
Demyelination 1 (100%)
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
Page 5
NTP Experiment-Test: 05182-04 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC PHENOLPHTHALEIN Date: 04/04/96
Route: DOSED FEED Time: 03:53:03
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE 0 PPM 3000 PPM 6000 PPM 12000
PPM
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (50) (50) (50) (50)
Hemorrhage 7 (14%) 4 (8%) 6 (12%) 4 (8%)
Infiltration Cellular, Histiocyte 2 (4%) 3 (6%)
Thrombosis 1 (2%)
Alveolar Epithelium, Hyperplasia 1 (2%) 1 (2%) 1 (2%)
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
None
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (50) (50) (50) (50)
Cyst 1 (2%) 1 (2%)
Hydronephrosis 1 (2%) 1 (2%) 1 (2%)
Infarct 1 (2%)
Inflammation, Chronic 1 (2%)
Mineralization 1 (2%)
Necrosis 1 (2%) 1 (2%)
Nephropathy, Chronic 15 (30%) 16 (32%) 19 (38%) 14 (28%)
Pigmentation 1 (2%)
Pelvis, Hemorrhage 1 (2%)
Renal Tubule, Accumulation, Hyaline Droplet 1 (2%) 3 (6%) 8 (16%)
Renal Tubule, Dilatation 2 (4%)
Urinary Bladder (50) (50) (49) (50)
Hyperplasia, Lymphoid 1 (2%)
Infiltration Cellular, Lymphocyte 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 6
NTP Experiment-Test: 05182-04 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC PHENOLPHTHALEIN Date: 04/04/96
Route: DOSED FEED Time: 03:53:03
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE 0 PPM 3000 PPM 6000 PPM 12000
PPM
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially In Study 50 50 50 50
Early Deaths
Moribund Sacrifice 6 13 11 3
Natural Death 4 4 3 10
Survivors
Terminal Sacrifice 40 33 36 36
Missing 1
Animals Examined Microscopically 50 50 50 49
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Gallbladder (50) (46) (46) (41)
Metaplasia 1 (2%)
Intestine Large, Rectum (50) (50) (50) (48)
Edema 1 (2%)
Intestine Large, Cecum (50) (48) (47) (45)
Edema 1 (2%)
Serosa, Inflammation, Chronic 1 (2%)
Intestine Small, Jejunum (49) (49) (48) (46)
Hemorrhage 1 (2%)
Necrosis 1 (2%)
Liver (50) (50) (50) (49)
Angiectasis 1 (2%) 1 (2%)
Clear Cell Focus 24 (48%) 6 (12%) 1 (2%)
Congestion 2 (4%)
Eosinophilic Focus 22 (44%) 6 (12%) 1 (2%) 1 (2%)
Fibrosis 1 (2%)
Hematopoietic Cell Proliferation 6 (12%) 6 (12%) 2 (4%)
Inflammation, Chronic 4 (8%) 3 (6%) 7 (14%) 5 (10%)
Mineralization 1 (2%) 1 (2%)
Mixed Cell Focus 6 (12%) 2 (4%) 1 (2%)
Necrosis 4 (8%) 4 (8%) 4 (8%) 2 (4%)
Vacuolization Cytoplasmic 7 (14%) 4 (8%) 2 (4%) 4 (8%)
Bile Duct, Cyst 1 (2%) 1 (2%)
Bile Duct, Inflammation, Suppurative 1 (2%)
Oval Cell, Hyperplasia 4 (8%) 2 (4%) 1 (2%)
Mesentery (9) (9) (4) (3)
Inflammation, Chronic Active 1 (11%)
Fat, Necrosis 7 (78%) 3 (33%) 2 (50%) 2 (67%)
Pancreas (50) (50) (50) (49)
Inflammation, Chronic 1 (2%)
Acinus, Atrophy 1 (2%) 1 (2%) 1 (2%) 4 (8%)
Duct, Cyst 1 (2%)
Salivary Glands (50) (50) (50) (49)
a Number of animals examined microscopically at site and number of animals with lesion
Page 7
NTP Experiment-Test: 05182-04 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC PHENOLPHTHALEIN Date: 04/04/96
Route: DOSED FEED Time: 03:53:03
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE 0 PPM 3000 PPM 6000 PPM 12000
PPM
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - CONT
Inflammation, Chronic 1 (2%)
Necrosis 1 (2%)
Duct, Cyst 1 (2%)
Stomach, Forestomach (50) (50) (50) (49)
Hyperkeratosis 1 (2%)
Hyperplasia, Squamous 4 (8%) 7 (14%) 8 (16%) 4 (8%)
Inflammation, Chronic 2 (4%) 1 (2%)
Mineralization 1 (2%)
Ulcer 1 (2%) 3 (6%) 3 (6%) 1 (2%)
Serosa, Inflammation, Chronic 1 (2%)
Stomach, Glandular (50) (50) (50) (48)
Cyst 1 (2%)
Erosion 1 (2%) 2 (4%) 5 (10%)
Mineralization 1 (2%)
Glands, Atrophy, Focal 1 (2%)
Glands, Cyst 1 (2%)
Glands, Hyperplasia 1 (2%) 1 (2%) 1 (2%) 2 (4%)
Serosa, Inflammation, Chronic 1 (2%)
Tooth (49) (50) (50) (49)
Degeneration 22 (45%) 12 (24%) 4 (8%) 1 (2%)
Inflammation, Chronic 1 (2%)
Inflammation, Chronic Active 1 (2%) 1 (2%) 2 (4%)
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Heart (50) (50) (50) (49)
Cardiomyopathy 1 (2%) 1 (2%) 2 (4%) 5 (10%)
Inflammation, Chronic 1 (2%)
Inflammation, Chronic Active 1 (2%)
Mineralization 1 (2%) 2 (4%) 1 (2%)
Myocardium, Degeneration 1 (2%)
Valve, Inflammation 1 (2%)
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Cortex (49) (50) (49) (48)
Hemorrhage 1 (2%)
Hyperplasia 1 (2%) 1 (2%)
Hypertrophy, Focal 16 (33%) 14 (28%) 10 (20%) 11 (23%)
Capsule, Hyperplasia 36 (73%) 37 (74%) 34 (69%) 34 (71%)
Capsule, Inflammation, Chronic 1 (2%)
Adrenal Medulla (49) (50) (49) (48)
Hyperplasia 1 (2%) 1 (2%)
Islets, Pancreatic (50) (50) (50) (49)
Hyperplasia 45 (90%) 45 (90%) 44 (88%) 41 (84%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 8
NTP Experiment-Test: 05182-04 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC PHENOLPHTHALEIN Date: 04/04/96
Route: DOSED FEED Time: 03:53:03
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE 0 PPM 3000 PPM 6000 PPM 12000
PPM
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - CONT
Parathyroid Gland (46) (48) (48) (45)
Cyst 2 (4%)
Pituitary Gland (48) (50) (49) (48)
Pars Distalis, Cyst 2 (4%) 1 (2%) 3 (6%) 2 (4%)
Pars Distalis, Hyperplasia 1 (2%) 1 (2%)
Thyroid Gland (49) (50) (50) (49)
Cyst 1 (2%)
Follicular Cell, Hyperplasia 5 (10%) 4 (8%) 1 (2%)
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
None
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Epididymis (50) (50) (50) (49)
Granuloma Sperm 1 (2%)
Inflammation, Chronic 1 (2%)
Inflammation, Granulomatous 1 (2%)
Spermatocele 1 (2%) 1 (2%)
Penis (1)
Hemorrhage 1 (100%)
Preputial Gland (49) (50) (49) (49)
Cyst 39 (80%) 37 (74%) 41 (84%) 47 (96%)
Granuloma 1 (2%)
Hyperplasia, Lymphoid 1 (2%)
Inflammation, Acute 1 (2%)
Inflammation, Chronic 5 (10%) 1 (2%) 3 (6%) 3 (6%)
Inflammation, Chronic Active 1 (2%) 2 (4%) 5 (10%) 7 (14%)
Prostate (50) (50) (50) (49)
Cyst 1 (2%)
Inflammation, Chronic 1 (2%)
Seminal Vesicle (50) (50) (50) (49)
Atrophy 1 (2%)
Hypertrophy 1 (2%)
Testes (50) (50) (50) (48)
Germinal Epithelium, Degeneration 1 (2%) 49 (98%) 50 (100%) 47 (98%)
Interstitial Cell, Hyperplasia 1 (2%)
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
Page 9
NTP Experiment-Test: 05182-04 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC PHENOLPHTHALEIN Date: 04/04/96
Route: DOSED FEED Time: 03:53:03
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE 0 PPM 3000 PPM 6000 PPM 12000
PPM
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Bone Marrow (50) (50) (50) (49)
Angiectasis 2 (4%)
Myelofibrosis 3 (6%) 8 (16%) 8 (16%) 19 (39%)
Pigmentation 2 (4%) 5 (10%) 16 (33%)
Thrombosis 2 (4%)
Myeloid Cell, Hyperplasia 1 (2%)
Lymph Node (8) (5) (14) (9)
Iliac, Angiectasis 1 (7%)
Iliac, Hyperplasia 1 (11%)
Iliac, Hyperplasia, Lymphoid 1 (13%) 2 (14%)
Iliac, Pigmentation 1 (13%)
Inguinal, Hyperplasia, Lymphoid 3 (38%) 2 (14%) 1 (11%)
Inguinal, Pigmentation 1 (7%)
Mediastinal, Hyperplasia, Lymphoid 1 (13%) 1 (7%)
Mediastinal, Infiltration Cellular, Plasma
Cell 1 (11%)
Pancreatic, Angiectasis 1 (13%) 1 (7%)
Renal, Angiectasis 1 (7%)
Renal, Hyperplasia, Lymphoid 1 (11%)
Lymph Node, Mandibular (49) (50) (49) (49)
Angiectasis 1 (2%)
Hyperplasia, Lymphoid 2 (4%) 1 (2%) 2 (4%) 1 (2%)
Infiltration Cellular, Histiocyte 1 (2%)
Lymph Node, Mesenteric (50) (50) (48) (49)
Angiectasis 11 (22%) 10 (20%) 13 (27%) 12 (24%)
Hyperplasia, Lymphoid 3 (6%) 2 (4%) 3 (6%)
Infiltration Cellular, Polymorphonuclear 2 (4%)
Infiltration Cellular, Histiocyte 1 (2%)
Inflammation, Chronic 1 (2%)
Spleen (50) (50) (50) (49)
Angiectasis 1 (2%)
Hematopoietic Cell Proliferation 10 (20%) 22 (44%) 28 (56%) 21 (43%)
Pigmentation 3 (6%) 5 (10%) 4 (8%)
Lymphoid Follicle, Atrophy 1 (2%)
Lymphoid Follicle, Hyperplasia 2 (4%) 2 (4%) 4 (8%)
Lymphoid Follicle, Necrosis 1 (2%)
Thymus (43) (46) (44) (42)
Atrophy 13 (30%) 11 (24%) 16 (36%) 12 (29%)
Cyst 1 (2%)
Hyperplasia, Atypical 3 (7%) 7 (16%) 7 (17%)
Hyperplasia, Oncocytic 1 (2%)
Necrosis 1 (2%)
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
Page 10
NTP Experiment-Test: 05182-04 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC PHENOLPHTHALEIN Date: 04/04/96
Route: DOSED FEED Time: 03:53:03
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE 0 PPM 3000 PPM 6000 PPM 12000
PPM
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Skin (50) (50) (50) (49)
Inflammation, Acute 1 (2%) 1 (2%)
Inflammation, Chronic 2 (4%) 1 (2%)
Subcutaneous Tissue, Edema 2 (4%) 7 (14%) 6 (12%)
Subcutaneous Tissue, Infiltration Cellular,
Polymorphonuclear 1 (2%)
Subcutaneous Tissue, Inflammation, Acute 1 (2%) 1 (2%)
Subcutaneous Tissue, Inflammation, Chronic 1 (2%)
Subcutaneous Tissue, Necrosis 1 (2%)
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
None
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
Brain (50) (50) (50) (49)
Hemorrhage 1 (2%) 1 (2%)
Necrosis 1 (2%)
Thalamus, Mineralization 27 (54%) 24 (48%) 25 (50%) 35 (71%)
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (50) (50) (50) (49)
Congestion 1 (2%) 2 (4%) 1 (2%) 1 (2%)
Hemorrhage 1 (2%) 3 (6%) 4 (8%) 7 (14%)
Infiltration Cellular, Histiocyte 5 (10%) 5 (10%) 2 (4%)
Inflammation, Granulomatous 1 (2%)
Alveolar Epithelium, Hyperplasia 3 (6%) 5 (10%) 3 (6%) 3 (6%)
Nose (50) (50) (50) (49)
Inflammation, Acute 2 (4%)
Polyp, Inflammatory 1 (2%) 1 (2%)
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
Harderian Gland (3) (4) (4) (3)
Hypertrophy 1 (25%) 2 (67%)
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
Page 11
NTP Experiment-Test: 05182-04 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC PHENOLPHTHALEIN Date: 04/04/96
Route: DOSED FEED Time: 03:53:03
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE 0 PPM 3000 PPM 6000 PPM 12000
PPM
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (50) (50) (50) (49)
Cyst 7 (14%) 5 (10%) 5 (10%) 4 (8%)
Hydronephrosis 2 (4%)
Infarct 1 (2%)
Infarct, Chronic 1 (2%)
Inflammation, Acute 1 (2%)
Metaplasia, Osseous 1 (2%)
Mineralization 7 (14%) 1 (2%) 2 (4%)
Nephropathy, Chronic 47 (94%) 46 (92%) 42 (84%) 41 (84%)
Pigmentation 1 (2%)
Papilla, Necrosis 1 (2%)
Pelvis, Angiectasis 1 (2%)
Renal Tubule, Accumulation, Hyaline Droplet 2 (4%) 5 (10%) 5 (10%)
Renal Tubule, Dilatation 1 (2%) 1 (2%) 2 (4%)
Renal Tubule, Hyperplasia 1 (2%)
Renal Tubule, Necrosis 1 (2%)
Transitional Epithelium, Hyperplasia 1 (2%)
Urinary Bladder (50) (50) (48) (49)
Hemorrhage 1 (2%)
Inflammation, Acute 1 (2%)
Serosa, Inflammation, Chronic 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 12
------------------------------------------------------------
---------- END OF REPORT ----------
------------------------------------------------------------