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TDMS Study 05182-04 Pathology Tables

NTP Experiment-Test: 05182-04  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                          PHENOLPHTHALEIN                                      Date: 04/04/96
Route: DOSED FEED                                                                                                 Time: 03:53:03




       Facility:  TSI Mason Research

       Chemical CAS #:  77-09-8

       Lock Date:  01/24/94

       Cage Range:  All

       Reasons For Removal:    All

       Removal Date Range:     All

       Treatment Groups:       Include All




































a  Number of animals examined microscopically at site and number of animals with lesion

                                                              Page   1


NTP Experiment-Test: 05182-04  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                          PHENOLPHTHALEIN                                      Date: 04/04/96  
Route: DOSED FEED                                                                                                 Time: 03:53:03  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE FEMALE                        0 PPM        3000 PPM     6000 PPM     12000                                     
                                                                                          PPM                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
DISPOSITION SUMMARY                                                                                                                 

  Animals Initially in Study                          50           50           50           50                                     
  Early Deaths                                                                                                                      
    Natural Death                                      6            6            7           10                                     
    Moribund Sacrifice                                 5           13            9           12                                     
  Survivors                                                                                                                         
    Terminal Sacrifice                                38           31           34           28                                     
    Moribund Sacrifice                                 1                                                                            

  Animals Examined Microscopically                    50           50           50           50                                     
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Gallbladder                                        (45)         (46)         (46)         (44)                                   
      Histiocytic Sarcoma                                           1 (2%)       1 (2%)       1 (2%)                                
   Intestine Large, Colon                             (50)         (48)         (48)         (48)                                   
   Intestine Large, Rectum                            (50)         (49)         (48)         (49)                                   
   Intestine Large, Cecum                             (50)         (48)         (48)         (45)                                   
      Fibrosarcoma                                                  1 (2%)                                                          
   Intestine Small, Duodenum                          (48)         (47)         (47)         (48)                                   
   Intestine Small, Jejunum                           (49)         (48)         (46)         (46)                                   
      Carcinoma                                                                  1 (2%)                                             
   Intestine Small, Ileum                             (48)         (47)         (46)         (47)                                   
   Liver                                              (50)         (50)         (50)         (50)                                   
      Fibrous Histiocytoma                             1 (2%)                                                                       
      Hemangiosarcoma, Metastatic, Spleen                           1 (2%)                                                          
      Hepatocellular Carcinoma                         6 (12%)      1 (2%)                    1 (2%)                                
      Hepatocellular Adenoma                          12 (24%)      2 (4%)       6 (12%)      1 (2%)                                
      Hepatocellular Adenoma, Multiple                 5 (10%)                                                                      
      Histiocytic Sarcoma                                           1 (2%)       6 (12%)      7 (14%)                               
   Mesentery                                          (16)         (2)          (7)          (1)                                    
      Fibrous Histiocytoma                             1 (6%)                                                                       
      Hemangiosarcoma                                                            1 (14%)                                            
   Pancreas                                           (50)         (50)         (50)         (50)                                   
      Fibrous Histiocytoma                             1 (2%)                                                                       
      Histiocytic Sarcoma                                                        1 (2%)       1 (2%)                                
   Salivary Glands                                    (49)         (50)         (50)         (49)                                   
   Stomach, Forestomach                               (50)         (50)         (50)         (50)                                   
      Squamous Cell Carcinoma                                       1 (2%)                                                          
      Squamous Cell Papilloma                          1 (2%)       1 (2%)                    3 (6%)                                
   Stomach, Glandular                                 (50)         (49)         (49)         (50)                                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    

                                                             Page   2                                                               
NTP Experiment-Test: 05182-04  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                          PHENOLPHTHALEIN                                      Date: 04/04/96  
Route: DOSED FEED                                                                                                 Time: 03:53:03  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE FEMALE                        0 PPM        3000 PPM     6000 PPM     12000                                     
                                                                                          PPM                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Heart                                              (50)         (50)         (50)         (50)                                   
      Alveolar/Bronchiolar Carcinoma, Metastatic,                                                                                   
           Lung                                        1 (2%)                                 1 (2%)                                
      Fibrous Histiocytoma                             1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Cortex                                     (50)         (50)         (50)         (50)                                   
   Adrenal Medulla                                    (50)         (50)         (50)         (50)                                   
   Islets, Pancreatic                                 (49)         (50)         (50)         (50)                                   
      Adenoma                                                                    1 (2%)                                             
   Pituitary Gland                                    (49)         (50)         (49)         (48)                                   
      Pars Distalis, Adenoma                           3 (6%)       2 (4%)       1 (2%)                                             
      Pars Intermedia, Adenoma                         1 (2%)                                                                       
   Thyroid Gland                                      (50)         (50)         (50)         (50)                                   
      Follicular Cell, Adenoma                         1 (2%)       2 (4%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   Tissue NOS                                                      (1)                                                              
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Clitoral Gland                                     (48)         (48)         (48)         (50)                                   
   Ovary                                              (50)         (49)         (50)         (50)                                   
      Cystadenoma                                                   3 (6%)                    1 (2%)                                
      Fibrous Histiocytoma                             1 (2%)                                                                       
      Granulosa Cell Tumor Benign                      1 (2%)       1 (2%)                                                          
      Hemangioma                                       2 (4%)                                 1 (2%)                                
      Histiocytic Sarcoma                                           1 (2%)                                                          
      Sex Cord Stromal Tumor, Benign                                6 (12%)      6 (12%)      5 (10%)                               
      Teratoma Benign                                  1 (2%)                                                                       
      Bilateral, Sex Cord Stromal Tumor, Benign                     1 (2%)                                                          
   Uterus                                             (50)         (50)         (50)         (50)                                   
      Carcinoma                                        1 (2%)                                                                       
      Histiocytic Sarcoma                                           1 (2%)                                                          
      Polyp Stromal                                    1 (2%)       2 (4%)       3 (6%)       1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    

                                                             Page   3                                                               
NTP Experiment-Test: 05182-04  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                          PHENOLPHTHALEIN                                      Date: 04/04/96  
Route: DOSED FEED                                                                                                 Time: 03:53:03  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE FEMALE                        0 PPM        3000 PPM     6000 PPM     12000                                     
                                                                                          PPM                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (50)         (50)         (50)         (50)                                   
      Hemangioma                                                                 1 (2%)                                             
      Histiocytic Sarcoma                                           1 (2%)       2 (4%)       5 (10%)                               
   Lymph Node                                         (14)         (17)         (13)         (16)                                   
      Iliac, Fibrous Histiocytoma                      1 (7%)                                                                       
      Iliac, Histiocytic Sarcoma                                                              3 (19%)                               
      Mediastinal, Alveolar/Bronchiolar Carcinoma,                                                                                  
           Metastatic, Lung                            2 (14%)                                                                      
      Mediastinal, Histiocytic Sarcoma                                                        1 (6%)                                
      Pancreatic, Histiocytic Sarcoma                                                         1 (6%)                                
      Renal, Histiocytic Sarcoma                                                              2 (13%)                               
   Lymph Node, Mandibular                             (49)         (50)         (49)         (49)                                   
      Histiocytic Sarcoma                                                        3 (6%)       4 (8%)                                
   Lymph Node, Mesenteric                             (49)         (50)         (49)         (50)                                   
      Fibrous Histiocytoma                             1 (2%)                    1 (2%)                                             
      Histiocytic Sarcoma                                           1 (2%)       3 (6%)       4 (8%)                                
   Spleen                                             (50)         (50)         (50)         (50)                                   
      Hemangiosarcoma                                               1 (2%)       2 (4%)       1 (2%)                                
      Histiocytic Sarcoma                                           1 (2%)       3 (6%)       6 (12%)                               
   Thymus                                             (48)         (44)         (49)         (45)                                   
      Alveolar/Bronchiolar Carcinoma, Metastatic,                                                                                   
           Lung                                                                               1 (2%)                                
      Fibrous Histiocytoma                             1 (2%)                                                                       
      Histiocytic Sarcoma                                                        1 (2%)       2 (4%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Mammary Gland                                      (50)         (50)         (50)         (50)                                   
      Adenoacanthoma                                                             1 (2%)                                             
   Skin                                               (50)         (50)         (50)         (50)                                   
      Basal Cell Adenoma                                            1 (2%)                                                          
      Trichoepithelioma                                                          1 (2%)                                             
      Subcutaneous Tissue, Hemangiosarcoma                                       1 (2%)       1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Bone                                               (50)         (50)         (50)         (50)                                   
      Osteosarcoma                                                  1 (2%)                    1 (2%)                                
   Skeletal Muscle                                    (1)          (1)          (1)                                                 
      Alveolar/Bronchiolar Carcinoma, Metastatic,                                                                                   
           Lung                                        1 (100%)                                                                     
      Hemangiosarcoma                                               1 (100%)     1 (100%)                                           
____________________________________________________________________________________________________________________________________
                                                                                                                                    

                                                             Page   4                                                               
NTP Experiment-Test: 05182-04  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                          PHENOLPHTHALEIN                                      Date: 04/04/96  
Route: DOSED FEED                                                                                                 Time: 03:53:03  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE FEMALE                        0 PPM        3000 PPM     6000 PPM     12000                                     
                                                                                          PPM                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (50)         (49)         (50)         (50)                                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (50)         (50)         (50)         (50)                                   
      Alveolar/Bronchiolar Adenoma                     3 (6%)       1 (2%)       4 (8%)       6 (12%)                               
      Alveolar/Bronchiolar Adenoma, Multiple                                     1 (2%)                                             
      Alveolar/Bronchiolar Carcinoma                   4 (8%)       4 (8%)       1 (2%)       2 (4%)                                
      Carcinoma, Metastatic, Uncertain Primary Site                 1 (2%)                                                          
      Fibrous Histiocytoma                             1 (2%)                                                                       
      Hepatocellular Carcinoma, Metastatic, Liver      2 (4%)       1 (2%)                                                          
      Histiocytic Sarcoma                                           1 (2%)       4 (8%)       4 (8%)                                
      Osteosarcoma, Metastatic, Bone                                                          1 (2%)                                
   Nose                                               (50)         (50)         (50)         (50)                                   
      Carcinoma, Metastatic, Harderian Gland                                                  1 (2%)                                
      Hemangiosarcoma                                                            1 (2%)                                             
      Osteosarcoma, Metastatic, Bone                                1 (2%)                                                          
   Trachea                                            (50)         (50)         (50)         (50)                                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Harderian Gland                                    (5)          (2)          (1)          (2)                                    
      Adenoma                                          2 (40%)      1 (50%)      1 (100%)     1 (50%)                               
      Carcinoma                                        2 (40%)                                1 (50%)                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (50)         (50)         (50)         (50)                                   
      Alveolar/Bronchiolar Carcinoma, Metastatic,                                                                                   
           Lung                                        1 (2%)                                                                       
      Histiocytic Sarcoma                                                                     1 (2%)                                
   Urinary Bladder                                    (50)         (50)         (49)         (50)                                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SYSTEMIC LESIONS                                                                                                                   

   Multiple Organs                                   *(50)        *(50)        *(50)        *(50)                                   
      Histiocytic Sarcoma                                           2 (4%)       7 (14%)      7 (14%)                               
      Lymphoma Malignant                              15 (30%)     28 (56%)     33 (66%)     25 (50%)                               
____________________________________________________________________________________________________________________________________

                                                                                                                                    
     *   Number of animals with any tissue examined microscopically                                                                 

                                                             Page   5                                                               
NTP Experiment-Test: 05182-04  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                          PHENOLPHTHALEIN                                      Date: 04/04/96  
Route: DOSED FEED                                                                                                 Time: 03:53:03  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE FEMALE                        0 PPM        3000 PPM     6000 PPM     12000                                     
                                                                                          PPM                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
TUMOR SUMMARY                                                                                                                       
                                                                                                                                    
   Total Animals with Primary Neoplasms (b)            40          39          47          43                                       
     Total Primary Neoplasms                           70          63          75          58                                       
                                                                                                                                    
   Total Animals with Benign Neoplasms                 26          20          23          17                                       
     Total Benign Neoplasms                            33          23          25          19                                       
                                                                                                                                    
   Total Animals with Malignant Neoplasms              25          34          41          37                                       
     Total Malignant Neoplasms                         37          40          50          39                                       
                                                                                                                                    
   Total Animals with Metastatic Neoplasms              3           4                       3                                       
     Total Metastatic Neoplasm                          7           4                       4                                       
                                                                                                                                    
   Total Animals with Malignant Neoplasms                           1                                                               
   Uncertain Primary Site                                                                                                           
                                                                                                                                    
   Total Animals with Neoplasms Uncertain-                                                                                          
   Benign or Malignant                                                                                                              
     Total Uncertain Neoplasms                                                                                                      
                                                                                                                                    

____________________________________________________________________________________________________________________________________
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Primary tumors: all tumors except metastatic tumors                                                                              

                                                             Page   6                                                               
NTP Experiment-Test: 05182-04  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                          PHENOLPHTHALEIN                                      Date: 04/04/96  
Route: DOSED FEED                                                                                                 Time: 03:53:03  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE MALE                          0 PPM        3000 PPM     6000 PPM     12000                                     
                                                                                          PPM                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
DISPOSITION SUMMARY                                                                                                                 

  Animals Initially in Study                          50           50           50           50                                     
  Early Deaths                                                                                                                      
    Moribund Sacrifice                                 6           13           11            3                                     
    Natural Death                                      4            4            3           10                                     
  Survivors                                                                                                                         
    Terminal Sacrifice                                40           33           36           36                                     
  Missing                                                                                     1                                     

  Animals Examined Microscopically                    50           50           50           49                                     
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Esophagus                                          (50)         (50)         (50)         (49)                                   
   Gallbladder                                        (50)         (46)         (46)         (41)                                   
      Fibrosarcoma, Metastatic, Mesentery                           1 (2%)                                                          
   Intestine Large, Rectum                            (50)         (50)         (50)         (48)                                   
      Fibrosarcoma, Metastatic, Mesentery                                        1 (2%)                                             
   Intestine Large, Cecum                             (50)         (48)         (47)         (45)                                   
      Carcinoma                                                     1 (2%)                                                          
   Intestine Small, Duodenum                          (49)         (48)         (48)         (46)                                   
      Carcinoma                                                                  1 (2%)                                             
      Fibrosarcoma, Metastatic, Mesentery                           1 (2%)                                                          
      Histiocytic Sarcoma                                           1 (2%)                                                          
   Intestine Small, Jejunum                           (49)         (49)         (48)         (46)                                   
      Fibrosarcoma, Metastatic, Mesentery                                        1 (2%)                                             
      Osteosarcoma, Metastatic, Uncertain Primary                                                                                   
          Site                                                                   1 (2%)                                             
   Intestine Small, Ileum                             (49)         (50)         (48)         (46)                                   
   Liver                                              (50)         (50)         (50)         (49)                                   
      Fibrosarcoma, Metastatic, Mesentery                           1 (2%)       1 (2%)                                             
      Hemangiosarcoma                                  1 (2%)       1 (2%)       2 (4%)                                             
      Hemangiosarcoma, Multiple                                     1 (2%)                                                          
      Hepatocellular Carcinoma                         7 (14%)      9 (18%)      4 (8%)       9 (18%)                               
      Hepatocellular Carcinoma, Multiple               1 (2%)       1 (2%)       1 (2%)                                             
      Hepatocellular Adenoma                          10 (20%)     11 (22%)      8 (16%)      9 (18%)                               
      Hepatocellular Adenoma, Multiple                12 (24%)      1 (2%)                    1 (2%)                                
      Hepatocholangiocarcinoma                                      1 (2%)                                                          
      Histiocytic Sarcoma                              1 (2%)       3 (6%)      10 (20%)     12 (24%)                               
      Ito Cell Tumor Malignant                         1 (2%)                                                                       
      Osteosarcoma, Metastatic, Uncertain Primary                                                                                   
          Site                                                                   1 (2%)                                             
      Sarcoma, Metastatic, Uncertain Primary Site                   1 (2%)                                                          
   Mesentery                                          (9)          (9)          (4)          (3)                                    
      Fibrosarcoma                                                  1 (11%)      1 (25%)                                            

                                                             Page   7                                                               
NTP Experiment-Test: 05182-04  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                          PHENOLPHTHALEIN                                      Date: 04/04/96  
Route: DOSED FEED                                                                                                 Time: 03:53:03  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE MALE                          0 PPM        3000 PPM     6000 PPM     12000                                     
                                                                                          PPM                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ALIMENTARY SYSTEM - cont                                                                                                            
      Hemangiosarcoma                                               2 (22%)                                                         
      Hepatocholangiocarcinoma, Metastatic, Liver                   1 (11%)                                                         
      Sarcoma, Metastatic, Uncertain Primary Site                   1 (11%)                                                         
   Pancreas                                           (50)         (50)         (50)         (49)                                   
      Fibrosarcoma, Metastatic, Mesentery                           1 (2%)       1 (2%)                                             
      Hepatocholangiocarcinoma, Metastatic, Liver                   1 (2%)                                                          
      Histiocytic Sarcoma                                                                     4 (8%)                                
      Sarcoma, Metastatic, Uncertain Primary Site                   1 (2%)                                                          
   Salivary Glands                                    (50)         (50)         (50)         (49)                                   
      Hemangiosarcoma                                                                         1 (2%)                                
   Stomach, Forestomach                               (50)         (50)         (50)         (49)                                   
      Squamous Cell Carcinoma                                                                 1 (2%)                                
      Squamous Cell Papilloma                                                    2 (4%)                                             
   Stomach, Glandular                                 (50)         (50)         (50)         (48)                                   
      Histiocytic Sarcoma                                           1 (2%)                                                          
      Squamous Cell Carcinoma, Metastatic, Stomach,                                                                                 
           Forestomach                                                                        1 (2%)                                
   Tongue                                             (1)          (1)                                                              
      Squamous Cell Carcinoma                          1 (100%)                                                                     
   Tooth                                              (49)         (50)         (50)         (49)                                   
      Sarcoma, Metastatic, Uncertain Primary Site                   1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Heart                                              (50)         (50)         (50)         (49)                                   
      Alveolar/Bronchiolar Carcinoma, Metastatic,                                                                                   
           Lung                                        1 (2%)                                                                       
      Fibrosarcoma, Metastatic, Mesentery                           1 (2%)                                                          
      Hemangiosarcoma                                               1 (2%)                                                          
      Histiocytic Sarcoma                                                                     3 (6%)                                
      Sarcoma, Metastatic, Uncertain Primary Site                   1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Cortex                                     (49)         (50)         (49)         (48)                                   
      Adenoma                                                       1 (2%)                                                          
      Hepatocholangiocarcinoma, Metastatic, Liver                   1 (2%)                                                          
      Capsule, Adenoma                                 1 (2%)       2 (4%)                                                          
      Capsule, Sarcoma, Metastatic, Uncertain                                                                                       
          Primary Site                                              1 (2%)                                                          
   Adrenal Medulla                                    (49)         (50)         (49)         (48)                                   
   Islets, Pancreatic                                 (50)         (50)         (50)         (49)                                   
      Adenoma                                          1 (2%)                                                                       
   Pituitary Gland                                    (48)         (50)         (49)         (48)                                   
      Pars Distalis, Adenoma                                        1 (2%)                                                          

                                                             Page   8                                                               
NTP Experiment-Test: 05182-04  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                          PHENOLPHTHALEIN                                      Date: 04/04/96  
Route: DOSED FEED                                                                                                 Time: 03:53:03  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE MALE                          0 PPM        3000 PPM     6000 PPM     12000                                     
                                                                                          PPM                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ENDOCRINE SYSTEM - cont                                                                                                             
      Pars Intermedia, Adenoma                         1 (2%)                                                                       
   Thyroid Gland                                      (49)         (50)         (50)         (49)                                   
      Follicular Cell, Adenoma                                      1 (2%)       2 (4%)                                             
      Follicular Cell, Carcinoma                       1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   Tissue NOS                                                      (1)                                                              
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Epididymis                                         (50)         (50)         (50)         (49)                                   
      Fibrosarcoma, Metastatic, Mesentery                           1 (2%)       1 (2%)                                             
      Hepatocholangiocarcinoma, Metastatic, Liver                   1 (2%)                                                          
      Histiocytic Sarcoma                                                                     1 (2%)                                
      Leiomyoma                                                     1 (2%)                                                          
   Preputial Gland                                    (49)         (50)         (49)         (49)                                   
      Fibrosarcoma, Metastatic, Skin                                             1 (2%)                                             
   Prostate                                           (50)         (50)         (50)         (49)                                   
      Fibrosarcoma, Metastatic, Mesentery                           1 (2%)                                                          
   Seminal Vesicle                                    (50)         (50)         (50)         (49)                                   
      Fibrosarcoma, Metastatic, Mesentery                           1 (2%)       1 (2%)                                             
      Hepatocholangiocarcinoma, Metastatic, Liver                   1 (2%)                                                          
   Testes                                             (50)         (50)         (50)         (48)                                   
      Hemangiosarcoma                                                            1 (2%)                                             
      Interstitial Cell, Adenoma                       1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (50)         (50)         (50)         (49)                                   
      Hemangiosarcoma                                               1 (2%)       1 (2%)                                             
      Histiocytic Sarcoma                                           1 (2%)       5 (10%)      5 (10%)                               
      Mast Cell Tumor Malignant                                                               1 (2%)                                
   Lymph Node                                         (8)          (5)          (14)         (9)                                    
      Iliac, Fibrosarcoma, Metastatic, Mesentery                    1 (20%)                                                         
      Iliac, Histiocytic Sarcoma                                                 2 (14%)      1 (11%)                               
      Inguinal, Mast Cell Tumor Malignant,                                                                                          
          Metastatic, Bone Marrow                                                             1 (11%)                               
      Mediastinal, Carcinoma, Metastatic, Kidney       1 (13%)                                                                      
      Mediastinal, Sarcoma, Metastatic, Uncertain                                                                                   
          Primary Site                                              1 (20%)                                                         
      Pancreatic, Histiocytic Sarcoma                                                         1 (11%)                               
      Renal, Histiocytic Sarcoma                                                 2 (14%)                                            
      Renal, Osteosarcoma, Metastatic, Uncertain                                                                                    

                                                             Page   9                                                               
NTP Experiment-Test: 05182-04  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                          PHENOLPHTHALEIN                                      Date: 04/04/96  
Route: DOSED FEED                                                                                                 Time: 03:53:03  
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         B6C3F1 MICE MALE                          0 PPM        3000 PPM     6000 PPM     12000                                     
                                                                                          PPM                                       
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HEMATOPOIETIC SYSTEM - cont                                                                                                         
          Primary Site                                                           1 (7%)                                             
   Lymph Node, Mandibular                             (49)         (50)         (49)         (49)                                   
      Histiocytic Sarcoma                                           2 (4%)                    4 (8%)                                
   Lymph Node, Mesenteric                             (50)         (50)         (48)         (49)                                   
      Fibrosarcoma, Metastatic, Mesentery                           1 (2%)                                                          
      Hepatocholangiocarcinoma, Metastatic, Liver                   1 (2%)                                                          
      Histiocytic Sarcoma                                           2 (4%)       4 (8%)       7 (14%)                               
   Spleen                                             (50)         (50)         (50)         (49)                                   
      Fibrosarcoma, Metastatic, Mesentery                           1 (2%)                                                          
      Hemangiosarcoma                                               5 (10%)      1 (2%)       1 (2%)                                
      Histiocytic Sarcoma                                           2 (4%)       6 (12%)      9 (18%)                               
   Thymus                                             (43)         (46)         (44)         (42)                                   
      Alveolar/Bronchiolar Carcinoma, Metastatic,                                                                                   
           Lung                                        1 (2%)                                                                       
      Fibrosarcoma, Metastatic, Mesentery                           1 (2%)                                                          
      Histiocytic Sarcoma                                                                     2 (5%)                                
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 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Skin                                               (50)         (50)         (50)         (49)                                   
      Subcutaneous Tissue, Fibrosarcoma                1 (2%)                    1 (2%)                                             
      Subcutaneous Tissue, Hemangiosarcoma             1 (2%)                    3 (6%)                                             
      Subcutaneous Tissue, Histiocytic Sarcoma                      1 (2%)       1 (2%)                                             
      Subcutaneous Tissue, Sarcoma, Metastatic,                                                                                     
           Uncertain Primary Site                                   1 (2%)                                                          
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 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Bone                                               (50)         (50)         (50)         (48)                                   
      Carcinoma, Metastatic, Kidney                    1 (2%)                                                                       
   Skeletal Muscle                                    (2)          (1)          (1)          (1)                                    
      Alveolar/Bronchiolar Carcinoma, Metastatic,                                                                                   
           Lung                                        1 (50%)                                                                      
      Carcinoma, Metastatic, Kidney                    1 (50%)                                                                      
      Fibrosarcoma, Metastatic, Mesentery                                        1 (100%)                                           
      Hepatocholangiocarcinoma, Metastatic, Liver                   1 (100%)                                                        
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 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (50)         (50)         (50)         (49)                                   
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                                                             Page  10                                                               
NTP Experiment-Test: 05182-04  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                          PHENOLPHTHALEIN                                      Date: 04/04/96  
Route: DOSED FEED                                                                                                 Time: 03:53:03  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE MALE                          0 PPM        3000 PPM     6000 PPM     12000                                     
                                                                                          PPM                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (50)         (50)         (50)         (49)                                   
      Alveolar/Bronchiolar Adenoma                     8 (16%)     10 (20%)      4 (8%)      10 (20%)                               
      Alveolar/Bronchiolar Adenoma, Multiple                                                  2 (4%)                                
      Alveolar/Bronchiolar Carcinoma                   3 (6%)       5 (10%)      4 (8%)       4 (8%)                                
      Alveolar/Bronchiolar Carcinoma, Multiple                                                1 (2%)                                
      Carcinoma, Metastatic, Harderian Gland                                     1 (2%)                                             
      Carcinoma, Metastatic, Kidney                    1 (2%)                                                                       
      Fibrosarcoma, Metastatic, Mesentery                           1 (2%)                                                          
      Hemangiosarcoma                                  1 (2%)                                                                       
      Hepatocellular Carcinoma, Metastatic, Liver      2 (4%)       3 (6%)       1 (2%)       3 (6%)                                
      Histiocytic Sarcoma                                           2 (4%)       4 (8%)       9 (18%)                               
      Sarcoma, Metastatic, Uncertain Primary Site                   1 (2%)                                                          
   Nose                                               (50)         (50)         (50)         (49)                                   
      Sarcoma, Metastatic, Uncertain Primary Site                   1 (2%)                                                          
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 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Ear                                                             (2)                                                              
   Harderian Gland                                    (3)          (4)          (4)          (3)                                    
      Adenoma                                          3 (100%)     3 (75%)      2 (50%)      1 (33%)                               
      Carcinoma                                                                  2 (50%)      1 (33%)                               
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 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (50)         (50)         (50)         (49)                                   
      Histiocytic Sarcoma                                           2 (4%)       2 (4%)       3 (6%)                                
      Sarcoma, Metastatic, Uncertain Primary Site                   1 (2%)                                                          
      Squamous Cell Carcinoma, Metastatic, Stomach,                                                                                 
           Forestomach                                                                        1 (2%)                                
      Renal Tubule, Adenoma                                                      2 (4%)                                             
      Transitional Epithelium, Carcinoma               1 (2%)                                                                       
   Urinary Bladder                                    (50)         (50)         (48)         (49)                                   
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 SYSTEMIC LESIONS                                                                                                                   

   Multiple Organs                                   *(50)        *(50)        *(50)        *(49)                                   
      Histiocytic Sarcoma                              1 (2%)       3 (6%)      11 (22%)     12 (24%)                               
      Lymphoma Malignant                               6 (12%)      8 (16%)     12 (24%)      8 (16%)                               
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     *   Number of animals with any tissue examined microscopically                                                                 

                                                             Page  11                                                               
NTP Experiment-Test: 05182-04  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                          PHENOLPHTHALEIN                                      Date: 04/04/96  
Route: DOSED FEED                                                                                                 Time: 03:53:03  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE MALE                          0 PPM        3000 PPM     6000 PPM     12000                                     
                                                                                          PPM                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
TUMOR SUMMARY                                                                                                                       
                                                                                                                                    
   Total Animals with Primary Neoplasms (b)            40          40          42          38                                       
     Total Primary Neoplasms                           63          71          65          62                                       
                                                                                                                                    
   Total Animals with Benign Neoplasms                 29          24          18          19                                       
     Total Benign Neoplasms                            37          31          20          23                                       
                                                                                                                                    
   Total Animals with Malignant Neoplasms              19          29          35          29                                       
     Total Malignant Neoplasms                         26          40          45          39                                       
                                                                                                                                    
   Total Animals with Metastatic Neoplasms              4           5           5           4                                       
     Total Metastatic Neoplasm                          9          34          13           6                                       
                                                                                                                                    
   Total Animals with Malignant Neoplasms                           1           1                                                   
   Uncertain Primary Site                                                                                                           
                                                                                                                                    
   Total Animals with Neoplasms Uncertain-                                                                                          
   Benign or Malignant                                                                                                              
     Total Uncertain Neoplasms                                                                                                      
                                                                                                                                    

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a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Primary tumors: all tumors except metastatic tumors                                                                              

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