TDMS Study 05182-04 Pathology Tables
NTP STATISTICAL ANALYSIS OF SURVIVAL DATA REPORT: PEIRPT11
LAB: TSI Mason Research PHENOLPHTHALEIN DATE: 04/04/96
EXPERIMENT: 05182 TEST: 04 TIME: 04:07:46
TEST TYPE: CHRONIC CAGES FROM 0000 TO LAST CAGE PAGE: 1
CONT: N01-ES-05302 ROUTE: DOSED FEED NTP C#: 55798B
PATHOLOGIST: A. RUSSFIELD CAS: 77-09-8
------------------------------------------------------------------------------------------------------------------------------------
REASONS FOR REMOVAL: ALL
REMOVAL DATE RANGE: ALL
TREATMENT GROUPS: INCLUDE ALL
NTP STATISTICAL ANALYSIS OF SURVIVAL DATA REPORT: PEIRPT11
LAB: TSI Mason Research PHENOLPHTHALEIN DATE: 04/04/96
EXPERIMENT: 05182 TEST: 04 TIME: 04:07:46
TEST TYPE: CHRONIC CAGES FROM 0000 TO LAST CAGE
CONT: N01-ES-05302 ROUTE: DOSED FEED NTP C#: 55798B
PATHOLOGIST: A. RUSSFIELD CAS: 77-09-8
PHENOLPHTHALEIN
STATISTICAL ANALYSIS OF SURVIVAL DATA
MALE MICE
FIRST TERMINAL SACRIFICE AT 729 DAYS
INDIVIDUAL SURVIVAL TIMES (DAYS)
==================================================================================
| DOSE = 0 PPM |
| --------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 10 CENSORED DEATHS 0 TERMINAL 40 |
| |
| UNCENSORED DEATHS |
| 232 533 550 582 599 613 662 673 724 727 |
| CENSORED DEATHS |
| NONE |
| |
|--------------------------------------------------------------------------------|
| DOSE = 3000 PPM |
| --------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 17 CENSORED DEATHS 0 TERMINAL 33 |
| |
| UNCENSORED DEATHS |
| 347 549 560 563 583 597 602 634 637 658 |
| 676 703 707 708 714 721 724 |
| CENSORED DEATHS |
| NONE |
| |
|--------------------------------------------------------------------------------|
| DOSE = 6000 PPM |
| --------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 14 CENSORED DEATHS 0 TERMINAL 36 |
| |
| UNCENSORED DEATHS |
| 423 495 500 515 535 556 657 659 665 673 |
| 696 700 713 716 |
| CENSORED DEATHS |
| NONE |
| |
==================================================================================
PHENOLPHTHALEIN
STATISTICAL ANALYSIS OF SURVIVAL DATA
MALE MICE
FIRST TERMINAL SACRIFICE AT 729 DAYS
INDIVIDUAL SURVIVAL TIMES (DAYS)
==================================================================================
| DOSE = 12000 PPM |
| --------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 13 CENSORED DEATHS 1 TERMINAL 36 |
| |
| UNCENSORED DEATHS |
| 3 522 549 585 639 645 646 652 699 703 |
| 714 720 723 |
| CENSORED DEATHS |
| 28 |
| |
==================================================================================
PHENOLPHTHALEIN
STATISTICAL ANALYSIS OF SURVIVAL DATA
MALE MICE
FIRST TERMINAL SACRIFICE AT 729 DAYS
==================================================================================
| KAPLAN-MEIER SURVIVAL PROBABILITY ESTIMATES (%) |
| |
|--------------------------------------------------------------------------------|
| DOSE TIME (DAYS) |
| 90 180 270 365 425 485 545 605 665 729 (A) |
| |
|--------------------------------------------------------------------------------|
| | |
|0 PPM | 100.0 100.0 98.0 98.0 98.0 98.0 96.0 90.0 86.0 80.0 |
| | |
| | |
|3000 PPM | 100.0 100.0 100.0 98.0 98.0 98.0 98.0 86.0 80.0 66.0 |
| | |
| | |
|6000 PPM | 100.0 100.0 100.0 100.0 98.0 98.0 90.0 88.0 82.0 72.0 |
| | |
| | |
|12000 PPM| 98.0 98.0 98.0 98.0 98.0 98.0 96.0 91.9 83.7 73.5 |
| | |
| | |
==================================================================================
==================================================================================
| SURVIVAL SUMMARY STATISTICS |
| |
| |
|--------------------------------------------------------------------------------|
| DOSE |
| |
| 0 PPM 3000 PPM 6000 PPM 12000 P|M
| |
|--------------------------------------------------------------------------------|
|SURVIVAL AT END OF STUDY| 80.0% 66.0% 72.0% 73.5% |
|(KAPLAN-MEIER) | |
| | |
|SIGNIFICANCE (B) | P=0.826 P=0.186 P=0.461 P=0.600 |
|(LIFE TABLE) | |
| | |
|MEAN DAY OF | 589.5 628.4 607.4 600.0 |
|NATURAL DEATHS (C) | (45.0) (23.1) (26.4) (52.9) |
|(STANDARD ERROR) | |
| | |
|MEAN LIFE SPAN (D) | 701.1 694.8 694.9 681.4 |
|(STANDARD ERROR) | (11.7) (10.3) (10.6) (20.5) |
| | |
==================================================================================
(A) FIRST TERMINAL SACRIFICE
(B) THE FIRST ENTRY IS THE TREND TEST (TARONE, 1975) RESULT.
SUBSEQUENT ENTRIES ARE THE RESULTS OF PAIRWISE TESTS
(COX,1972). NEGATIVE TRENDS ARE INDICATED BY "N".
(C) MEAN OF ALL UNCENSORED DEATHS PRIOR TO TERMINAL SACRIFICE
(D) MEAN OF ALL DEATHS (UNCENSORED, CENSORED, TERMINAL SACRIFICE)
PHENOLPHTHALEIN
STATISTICAL ANALYSIS OF SURVIVAL DATA
FEMALE MICE
FIRST TERMINAL SACRIFICE AT 737 DAYS
INDIVIDUAL SURVIVAL TIMES (DAYS)
==================================================================================
| DOSE = 0 PPM |
| --------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 11 CENSORED DEATHS 0 TERMINAL 39 |
| |
| UNCENSORED DEATHS |
| 78 156 546 597 613 615 628 686 708 723 |
| 730 |
| CENSORED DEATHS |
| NONE |
| |
|--------------------------------------------------------------------------------|
| DOSE = 3000 PPM |
| --------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 19 CENSORED DEATHS 0 TERMINAL 31 |
| |
| UNCENSORED DEATHS |
| 126 266 435 450 500 511 550 570 578 581 |
| 581 608 615 643 659 663 668 703 708 |
| CENSORED DEATHS |
| NONE |
| |
|--------------------------------------------------------------------------------|
| DOSE = 6000 PPM |
| --------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 16 CENSORED DEATHS 0 TERMINAL 34 |
| |
| UNCENSORED DEATHS |
| 329 338 479 551 561 567 602 604 615 622 |
| 645 651 654 686 686 693 |
| CENSORED DEATHS |
| NONE |
| |
==================================================================================
PHENOLPHTHALEIN
STATISTICAL ANALYSIS OF SURVIVAL DATA
FEMALE MICE
FIRST TERMINAL SACRIFICE AT 737 DAYS
INDIVIDUAL SURVIVAL TIMES (DAYS)
==================================================================================
| DOSE = 12000 PPM |
| --------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 22 CENSORED DEATHS 0 TERMINAL 28 |
| |
| UNCENSORED DEATHS |
| 40 447 449 450 505 514 568 573 578 588 |
| 589 594 598 601 602 640 652 667 680 715 |
| 722 730 |
| CENSORED DEATHS |
| NONE |
| |
==================================================================================
PHENOLPHTHALEIN
STATISTICAL ANALYSIS OF SURVIVAL DATA
FEMALE MICE
FIRST TERMINAL SACRIFICE AT 737 DAYS
==================================================================================
| KAPLAN-MEIER SURVIVAL PROBABILITY ESTIMATES (%) |
| |
|--------------------------------------------------------------------------------|
| DOSE TIME (DAYS) |
| 90 180 270 365 425 485 545 605 665 737 (A) |
| |
|--------------------------------------------------------------------------------|
| | |
|0 PPM | 98.0 96.0 96.0 96.0 96.0 96.0 96.0 92.0 86.0 78.0 |
| | |
| | |
|3000 PPM | 100.0 98.0 96.0 96.0 96.0 92.0 88.0 78.0 68.0 62.0 |
| | |
| | |
|6000 PPM | 100.0 100.0 100.0 96.0 96.0 94.0 94.0 84.0 74.0 68.0 |
| | |
| | |
|12000 PPM| 98.0 98.0 98.0 98.0 98.0 92.0 88.0 70.0 66.0 56.0 |
| | |
| | |
==================================================================================
==================================================================================
| SURVIVAL SUMMARY STATISTICS |
| |
| |
|--------------------------------------------------------------------------------|
| DOSE |
| |
| 0 PPM 3000 PPM 6000 PPM 12000 P|M
| |
|--------------------------------------------------------------------------------|
|SURVIVAL AT END OF STUDY| 78.0% 62.0% 68.0% 56.0% |
|(KAPLAN-MEIER) | |
| | |
|SIGNIFICANCE (B) | P=0.047 P=0.097 P=0.331 P=0.024 |
|(LIFE TABLE) | |
| | |
|MEAN DAY OF | 552.7 548.2 580.2 568.3 |
|NATURAL DEATHS (C) | (67.4) (33.9) (27.9) (30.8) |
|(STANDARD ERROR) | |
| | |
|MEAN LIFE SPAN (D) | 696.5 665.2 686.8 662.8 |
|(STANDARD ERROR) | (18.0) (18.2) (13.6) (18.0) |
| | |
==================================================================================
(A) FIRST TERMINAL SACRIFICE
(B) THE FIRST ENTRY IS THE TREND TEST (TARONE, 1975) RESULT.
SUBSEQUENT ENTRIES ARE THE RESULTS OF PAIRWISE TESTS
(COX,1972). NEGATIVE TRENDS ARE INDICATED BY "N".
(C) MEAN OF ALL UNCENSORED DEATHS PRIOR TO TERMINAL SACRIFICE
(D) MEAN OF ALL DEATHS (UNCENSORED, CENSORED, TERMINAL SACRIFICE)
PHENOLPHTHALEIN
KAPLAN-MEIER SURVIVAL CURVES
0 PPM = 1
3000 PPM = 2
6000 PPM = 3
12000 PPM = 4
------------------------------------------------------ SPECIES=MICE SEX=MALE -------------------------------------------------------
Plot of SURVIVAL*WEEK. Symbol is value of DOSE.
|
|
100 + 14 1 2 3
|
| 4 1 2 3 3 4 1 2
| 33 4 1 12
95 +
| 3 3 122 1
P | 3 3 2 1 1 4
E |
R 90 + 3 3 2 1 1 44
C |
E | 3 1 3 1
N | 2 2 43 1 1
T 85 +
| 4 1 4 1
S | 2 2 3 3
U | 44
R 80 + 2 2 344 1 1
V |
I | 2 244
V | 3 3
A 75 + 44
L | 2234 4
| 3 3
|
70 + 22
|
| 22
| 2 2
65 +
|
--+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+--
0 10 20 30 40 50 60 70 80 90 100 110
WEEK
NOTE: 14 obs hidden.
PHENOLPHTHALEIN
KAPLAN-MEIER SURVIVAL CURVES
0 PPM = 1
3000 PPM = 2
6000 PPM = 3
12000 PPM = 4
----------------------------------------------------- SPECIES=MICE SEX=FEMALE ------------------------------------------------------
Plot of SURVIVAL*WEEK. Symbol is value of DOSE.
|
|
104 +
|
| 1 4 1 2 3
| 4 1 2 1 2 3 3 4
P 96 + 1 2 3 24 4 3 1
E | 2 2 3 13 1
R | 2 24 3 3 1 1
C | 224
E 88 + 24 2 34 3 1 1
N | 2 2 33 1 1
T | 22 33 1 1
| 44 33 1 1
S 80 + 4 4 3 3 1 1
U | 2 2 11
R | 4422 33
V | 2 2 3 3
I 72 + 2 2
V | 4 4 33
A | 4 4 22 3 3
L | 4 2 2
64 + 4 4 22
| 4 24 2
| 44
| 4 4
56 + 44
|
--+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+--
0 10 20 30 40 50 60 70 80 90 100 110
WEEK
NOTE: 8 obs hidden.