TDMS Study 05182-03 Pathology Tables
NTP Experiment-Test: 05182-03 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC PHENOLPHTHALEIN Date: 04/04/96
Route: DOSED FEED Time: 03:10:03
Facility: TSI Mason Research
Chemical CAS #: 77-09-8
Lock Date: 01/24/94
Cage Range: All
Reasons For Removal: All
Removal Date Range: All
Treatment Groups: Include All
a Number of animals examined microscopically at site and number of animals with lesion
Page 1
NTP Experiment-Test: 05182-03 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC PHENOLPHTHALEIN Date: 04/04/96
Route: DOSED FEED Time: 03:10:03
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE 0 PPM 12000 25000 50000
PPM PPM PPM
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially in Study 50 50 50 50
Early Deaths
Moribund Sacrifice 9 8 7 8
Natural Death 11 4 11 4
Survivors
Terminal Sacrifice 30 38 32 38
Animals Examined Microscopically 50 50 50 50
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Intestine Large, Colon (48) (49) (49) (49)
Intestine Large, Cecum (45) (49) (47) (48)
Intestine Small, Duodenum (46) (49) (49) (48)
Intestine Small, Jejunum (44) (49) (47) (48)
Intestine Small, Ileum (47) (49) (45) (49)
Liver (50) (50) (50) (49)
Hepatocellular Carcinoma 1 (2%)
Hepatocellular Adenoma 1 (2%) 1 (2%) 1 (2%)
Hepatocellular Adenoma, Multiple 1 (2%)
Mesentery (12) (7) (6) (7)
Carcinoma, Metastatic, Uterus 1 (8%)
Oral Mucosa (3)
Squamous Cell Papilloma 2 (67%)
Pancreas (49) (49) (49) (46)
Carcinoma, Metastatic, Uterus 1 (2%)
Acinus, Adenoma 1 (2%)
Salivary Glands (50) (50) (50) (49)
Stomach, Forestomach (49) (50) (50) (49)
Stomach, Glandular (48) (50) (50) (48)
Tongue (2) (3) (2)
Squamous Cell Carcinoma 2 (100%) 1 (33%)
Tooth (1) (2)
Adamantinoma Malignant 1 (100%)
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Heart (50) (50) (50) (49)
Schwannoma Malignant 1 (2%)
____________________________________________________________________________________________________________________________________
Page 2
NTP Experiment-Test: 05182-03 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC PHENOLPHTHALEIN Date: 04/04/96
Route: DOSED FEED Time: 03:10:03
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE 0 PPM 12000 25000 50000
PPM PPM PPM
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Cortex (50) (50) (49) (49)
Adenoma 2 (4%) 1 (2%) 1 (2%) 2 (4%)
Adrenal Medulla (50) (50) (50) (49)
Pheochromocytoma Malignant 1 (2%) 1 (2%)
Pheochromocytoma Benign 2 (4%) 9 (18%) 9 (18%) 2 (4%)
Bilateral, Pheochromocytoma Benign 1 (2%) 2 (4%)
Islets, Pancreatic (49) (49) (49) (47)
Adenoma 2 (4%) 1 (2%) 1 (2%)
Carcinoma 3 (6%) 1 (2%)
Pituitary Gland (50) (49) (50) (47)
Pars Distalis, Adenoma 35 (70%) 32 (65%) 29 (58%) 25 (53%)
Pars Distalis, Carcinoma 1 (2%)
Thyroid Gland (50) (50) (50) (48)
C-Cell, Adenoma 7 (14%) 5 (10%) 7 (14%) 7 (15%)
C-Cell, Carcinoma 1 (2%) 3 (6%) 2 (4%)
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
None
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Clitoral Gland (50) (50) (49) (48)
Adenoma 9 (18%) 7 (14%) 3 (6%) 7 (15%)
Carcinoma 1 (2%) 1 (2%)
Bilateral, Adenoma 1 (2%) 1 (2%)
Ovary (50) (50) (50) (50)
Cystadenoma 1 (2%)
Granulosa Cell Tumor Malignant 1 (2%)
Granulosa Cell Tumor Benign 2 (4%)
Granulosa-Theca Tumor Benign 1 (2%)
Bilateral, Tubulostromal Adenoma 1 (2%)
Uterus (50) (50) (50) (50)
Carcinoma 1 (2%)
Histiocytic Sarcoma 1 (2%)
Schwannoma Malignant 1 (2%)
Endometrium, Polyp Stromal 3 (6%) 7 (14%) 5 (10%) 4 (8%)
Endometrium, Polyp Stromal, Multiple 1 (2%) 1 (2%) 1 (2%) 1 (2%)
Endometrium, Sarcoma Stromal 1 (2%)
Vagina (1) (1)
Schwannoma Malignant 1 (100%)
____________________________________________________________________________________________________________________________________
Page 3
NTP Experiment-Test: 05182-03 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC PHENOLPHTHALEIN Date: 04/04/96
Route: DOSED FEED Time: 03:10:03
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE 0 PPM 12000 25000 50000
PPM PPM PPM
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Bone Marrow (50) (50) (50) (50)
Histiocytic Sarcoma 1 (2%) 1 (2%)
Lymph Node (7) (11) (9) (9)
Mediastinal, Carcinoma, Metastatic, Uterus 1 (14%)
Lymph Node, Mandibular (50) (50) (50) (48)
Lymph Node, Mesenteric (49) (50) (49) (48)
Carcinoma, Metastatic, Uterus 1 (2%)
Spleen (50) (50) (50) (49)
Fibrosarcoma 1 (2%)
Histiocytic Sarcoma, Metastatic, Bone Marrow 1 (2%)
Thymus (50) (49) (49) (48)
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Mammary Gland (50) (50) (48) (49)
Adenoma 2 (4%)
Carcinoma 3 (6%) 3 (6%)
Fibroadenoma 21 (42%) 25 (50%) 11 (23%) 19 (39%)
Fibroadenoma, Multiple 9 (18%) 6 (13%) 5 (10%)
Skin (50) (50) (49) (50)
Lip, Basal Cell Adenoma 1 (2%)
Pinna, Squamous Cell Papilloma 1 (2%)
Subcutaneous Tissue, Fibroma 1 (2%) 2 (4%) 1 (2%)
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
Skeletal Muscle (3) (3) (2)
Sarcoma 1 (33%)
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
Brain (50) (50) (50) (50)
Cerebellum, Granular Cell Tumor Malignant 1 (2%)
Cerebrum, Astrocytoma Malignant 2 (4%)
Spinal Cord (1) (2) (2) (2)
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (50) (50) (50) (50)
Alveolar/Bronchiolar Adenoma 3 (6%) 3 (6%) 1 (2%) 2 (4%)
Alveolar/Bronchiolar Carcinoma 1 (2%)
Carcinoma, Metastatic, Uterus 1 (2%)
Page 4
NTP Experiment-Test: 05182-03 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC PHENOLPHTHALEIN Date: 04/04/96
Route: DOSED FEED Time: 03:10:03
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE 0 PPM 12000 25000 50000
PPM PPM PPM
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont
Histiocytic Sarcoma, Metastatic, Bone Marrow 1 (2%)
Nose (50) (49) (50) (50)
Turbinate, Adenoma 1 (2%)
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
Zymbal's Gland (1) (1)
Carcinoma 1 (100%)
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (50) (50) (50) (50)
Pelvis, Transitional Epithelium, Papilloma 1 (2%)
Renal Tubule, Adenoma 1 (2%)
Urinary Bladder (49) (49) (49) (49)
Carcinoma, Metastatic, Uterus 1 (2%)
Transitional Epithelium, Papilloma 1 (2%)
____________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS
Multiple Organs *(50) *(50) *(50) *(50)
Histiocytic Sarcoma 1 (2%) 1 (2%) 1 (2%)
Leukemia Mononuclear 21 (42%) 21 (42%) 17 (34%) 14 (28%)
____________________________________________________________________________________________________________________________________
* Number of animals with any tissue examined microscopically
Page 5
NTP Experiment-Test: 05182-03 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC PHENOLPHTHALEIN Date: 04/04/96
Route: DOSED FEED Time: 03:10:03
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE 0 PPM 12000 25000 50000
PPM PPM PPM
____________________________________________________________________________________________________________________________________
TUMOR SUMMARY
Total Animals with Primary Neoplasms (b) 49 50 50 49
Total Primary Neoplasms 138 133 98 108
Total Animals with Benign Neoplasms 43 49 42 41
Total Benign Neoplasms 102 102 76 82
Total Animals with Malignant Neoplasms 30 25 21 23
Total Malignant Neoplasms 36 31 22 26
Total Animals with Metastatic Neoplasms 2
Total Metastatic Neoplasm 8
Total Animals with Malignant Neoplasms
Uncertain Primary Site
Total Animals with Neoplasms Uncertain-
Benign or Malignant
Total Uncertain Neoplasms
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
b Primary tumors: all tumors except metastatic tumors
Page 6
NTP Experiment-Test: 05182-03 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC PHENOLPHTHALEIN Date: 04/04/96
Route: DOSED FEED Time: 03:10:03
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE 0 PPM 12000 25000 50000
PPM PPM PPM
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially in Study 50 50 50 50
Early Deaths
Moribund Sacrifice 15 15 13 16
Natural Death 14 20 22 21
Survivors
Terminal Sacrifice 21 15 14 13
Natural Death 1
Animals Examined Microscopically 50 50 50 50
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Intestine Large, Colon (48) (49) (49) (48)
Intestine Large, Rectum (48) (49) (50) (50)
Intestine Large, Cecum (44) (41) (44) (40)
Intestine Small, Duodenum (47) (50) (49) (47)
Intestine Small, Jejunum (47) (41) (47) (42)
Intestine Small, Ileum (44) (40) (40) (41)
Liver (50) (50) (50) (50)
Hepatocellular Adenoma 1 (2%) 3 (6%) 1 (2%)
Hepatocellular Adenoma, Multiple 1 (2%)
Histiocytic Sarcoma 1 (2%)
Mesentery (20) (7) (3) (3)
Histiocytic Sarcoma 1 (33%)
Oral Mucosa (1) (1)
Pharyngeal, Squamous Cell Carcinoma 1 (100%)
Pharyngeal, Squamous Cell Papilloma 1 (100%)
Pancreas (50) (50) (50) (47)
Histiocytic Sarcoma 1 (2%)
Acinus, Adenoma 2 (4%) 1 (2%)
Acinus, Adenoma, Multiple 1 (2%)
Salivary Glands (50) (49) (49) (49)
Stomach, Forestomach (50) (50) (50) (49)
Stomach, Glandular (50) (50) (50) (49)
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Heart (50) (49) (50) (50)
Schwannoma Malignant 1 (2%)
____________________________________________________________________________________________________________________________________
Page 7
NTP Experiment-Test: 05182-03 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC PHENOLPHTHALEIN Date: 04/04/96
Route: DOSED FEED Time: 03:10:03
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE 0 PPM 12000 25000 50000
PPM PPM PPM
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Cortex (50) (50) (50) (50)
Adenoma 1 (2%)
Adrenal Medulla (50) (50) (50) (50)
Pheochromocytoma Malignant 1 (2%) 1 (2%) 2 (4%)
Pheochromocytoma Benign 14 (28%) 15 (30%) 15 (30%) 19 (38%)
Bilateral, Pheochromocytoma Malignant 1 (2%)
Bilateral, Pheochromocytoma Benign 3 (6%) 19 (38%) 19 (38%) 15 (30%)
Islets, Pancreatic (50) (50) (50) (48)
Adenoma 3 (6%) 2 (4%) 1 (2%)
Carcinoma 1 (2%) 2 (4%) 1 (2%) 2 (4%)
Parathyroid Gland (41) (48) (49) (46)
Adenoma 1 (2%)
Pituitary Gland (50) (50) (50) (50)
Pars Distalis, Adenoma 13 (26%) 11 (22%) 16 (32%) 11 (22%)
Pars Intermedia, Adenoma 1 (2%)
Thyroid Gland (50) (50) (49) (49)
Bilateral, C-Cell, Adenoma 1 (2%)
Bilateral, Follicular Cell, Adenoma 1 (2%)
C-Cell, Adenoma 8 (16%) 2 (4%) 3 (6%) 4 (8%)
C-Cell, Carcinoma 1 (2%) 2 (4%)
Follicular Cell, Adenoma 2 (4%) 3 (6%)
Follicular Cell, Carcinoma 1 (2%)
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
None
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Epididymis (50) (50) (50) (50)
Preputial Gland (50) (49) (50) (49)
Adenoma 4 (8%) 4 (8%) 4 (8%) 4 (8%)
Carcinoma 2 (4%) 2 (4%)
Bilateral, Adenoma 1 (2%)
Bilateral, Carcinoma 1 (2%)
Prostate (50) (50) (50) (50)
Adenoma 2 (4%)
Seminal Vesicle (50) (50) (50) (50)
Testes (50) (50) (50) (50)
Bilateral, Interstitial Cell, Adenoma 42 (84%) 42 (84%) 46 (92%) 45 (90%)
Interstitial Cell, Adenoma 4 (8%) 4 (8%) 3 (6%) 4 (8%)
____________________________________________________________________________________________________________________________________
Page 8
NTP Experiment-Test: 05182-03 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC PHENOLPHTHALEIN Date: 04/04/96
Route: DOSED FEED Time: 03:10:03
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE 0 PPM 12000 25000 50000
PPM PPM PPM
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Bone Marrow (48) (50) (50) (49)
Lymph Node (17) (22) (27) (20)
Mediastinal, Carcinoma, Metastatic, Kidney 1 (5%)
Renal, Carcinoma, Metastatic, Kidney 1 (5%)
Lymph Node, Mandibular (50) (49) (49) (49)
Lymph Node, Mesenteric (50) (50) (47) (48)
Histiocytic Sarcoma 1 (2%)
Spleen (50) (50) (50) (49)
Fibrosarcoma 1 (2%)
Hemangioma 1 (2%)
Histiocytic Sarcoma 1 (2%)
Thymus (50) (49) (47) (47)
Histiocytic Sarcoma 1 (2%)
Thymoma Benign 1 (2%)
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Mammary Gland (43) (47) (48) (47)
Adenoma 1 (2%) 1 (2%)
Fibroadenoma 5 (12%) 2 (4%) 2 (4%) 1 (2%)
Fibroadenoma, Multiple 1 (2%)
Skin (49) (50) (50) (50)
Basal Cell Adenoma 2 (4%) 1 (2%)
Keratoacanthoma 4 (8%) 2 (4%) 3 (6%) 1 (2%)
Squamous Cell Carcinoma 1 (2%)
Pinna, Schwannoma Malignant 1 (2%) 2 (4%)
Subcutaneous Tissue, Fibroma 2 (4%) 2 (4%) 1 (2%) 2 (4%)
Subcutaneous Tissue, Fibroma, Multiple 1 (2%)
Subcutaneous Tissue, Histiocytic Sarcoma 1 (2%)
Subcutaneous Tissue, Schwannoma Malignant 1 (2%) 1 (2%)
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
Bone (50) (50) (50) (50)
Cranium, Osteosarcoma 1 (2%)
Skeletal Muscle (2) (5) (4) (1)
Osteosarcoma 1 (25%)
____________________________________________________________________________________________________________________________________
Page 9
NTP Experiment-Test: 05182-03 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC PHENOLPHTHALEIN Date: 04/04/96
Route: DOSED FEED Time: 03:10:03
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE 0 PPM 12000 25000 50000
PPM PPM PPM
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
Brain (50) (50) (50) (50)
Cerebrum, Oligodendroglioma Malignant 1 (2%)
Spinal Cord (2) (3) (3)
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (50) (50) (50) (50)
Alveolar/Bronchiolar Adenoma 1 (2%) 1 (2%) 1 (2%)
Alveolar/Bronchiolar Carcinoma 1 (2%)
Carcinoma, Metastatic, Kidney 1 (2%)
Chordoma, Metastatic, Uncertain Primary Site 1 (2%)
Histiocytic Sarcoma 1 (2%)
Osteosarcoma, Metastatic, Bone 1 (2%)
Osteosarcoma, Metastatic, Skeletal Muscle 1 (2%)
Nose (50) (50) (50) (50)
Squamous Cell Carcinoma, Metastatic, Oral
Mucosa 1 (2%)
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
Zymbal's Gland (1) (1) (2)
Adenoma 1 (100%)
Carcinoma 1 (100%) 2 (100%)
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (50) (50) (50) (50)
Liposarcoma 1 (2%)
Renal Tubule, Adenoma 4 (8%) 2 (4%) 6 (12%)
Renal Tubule, Carcinoma 1 (2%) 1 (2%) 2 (4%)
Renal Tubule, Oncocytoma Benign 1 (2%)
Transitional Epithelium, Carcinoma 1 (2%)
Urinary Bladder (49) (50) (50) (50)
Transitional Epithelium, Carcinoma 1 (2%)
____________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS
Multiple Organs *(50) *(50) *(50) *(50)
Histiocytic Sarcoma 1 (2%)
Leukemia Mononuclear 31 (62%) 27 (54%) 24 (48%) 29 (58%)
Mesothelioma Malignant 2 (4%) 2 (4%) 2 (4%)
* Number of animals with any tissue examined microscopically
Page 10
NTP Experiment-Test: 05182-03 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC PHENOLPHTHALEIN Date: 04/04/96
Route: DOSED FEED Time: 03:10:03
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE 0 PPM 12000 25000 50000
PPM PPM PPM
____________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS - cont
Multiple Organs *(50) *(50) *(50) *(50)
____________________________________________________________________________________________________________________________________
Page 11
NTP Experiment-Test: 05182-03 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC PHENOLPHTHALEIN Date: 04/04/96
Route: DOSED FEED Time: 03:10:03
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE 0 PPM 12000 25000 50000
PPM PPM PPM
____________________________________________________________________________________________________________________________________
TUMOR SUMMARY
Total Animals with Primary Neoplasms (b) 49 50 50 50
Total Primary Neoplasms 159 155 157 166
Total Animals with Benign Neoplasms 47 50 49 50
Total Benign Neoplasms 117 116 122 121
Total Animals with Malignant Neoplasms 35 36 31 33
Total Malignant Neoplasms 42 39 35 45
Total Animals with Metastatic Neoplasms 1 2 2 4
Total Metastatic Neoplasm 3 14 2 7
Total Animals with Malignant Neoplasms 1
Uncertain Primary Site
Total Animals with Neoplasms Uncertain-
Benign or Malignant
Total Uncertain Neoplasms
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
b Primary tumors: all tumors except metastatic tumors
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