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TDMS Study 05182-03 Pathology Tables

NTP Experiment-Test: 05182-03  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                          PHENOLPHTHALEIN                                      Date: 04/04/96
Route: DOSED FEED                                                                                                 Time: 03:10:03




       Facility:  TSI Mason Research

       Chemical CAS #:  77-09-8

       Lock Date:  01/24/94

       Cage Range:  All

       Reasons For Removal:    All

       Removal Date Range:     All

       Treatment Groups:       Include All




































a  Number of animals examined microscopically at site and number of animals with lesion

                                                              Page   1


NTP Experiment-Test: 05182-03  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                          PHENOLPHTHALEIN                                      Date: 04/04/96  
Route: DOSED FEED                                                                                                 Time: 03:10:03  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS FEMALE                   0 PPM        12000        25000        50000                                     
                                                                PPM          PPM          PPM                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
DISPOSITION SUMMARY                                                                                                                 

  Animals Initially in Study                          50           50           50           50                                     
  Early Deaths                                                                                                                      
    Moribund Sacrifice                                 9            8            7            8                                     
    Natural Death                                     11            4           11            4                                     
  Survivors                                                                                                                         
    Terminal Sacrifice                                30           38           32           38                                     

  Animals Examined Microscopically                    50           50           50           50                                     
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Intestine Large, Colon                             (48)         (49)         (49)         (49)                                   
   Intestine Large, Cecum                             (45)         (49)         (47)         (48)                                   
   Intestine Small, Duodenum                          (46)         (49)         (49)         (48)                                   
   Intestine Small, Jejunum                           (44)         (49)         (47)         (48)                                   
   Intestine Small, Ileum                             (47)         (49)         (45)         (49)                                   
   Liver                                              (50)         (50)         (50)         (49)                                   
      Hepatocellular Carcinoma                                      1 (2%)                                                          
      Hepatocellular Adenoma                                        1 (2%)       1 (2%)       1 (2%)                                
      Hepatocellular Adenoma, Multiple                              1 (2%)                                                          
   Mesentery                                          (12)         (7)          (6)          (7)                                    
      Carcinoma, Metastatic, Uterus                    1 (8%)                                                                       
   Oral Mucosa                                                     (3)                                                              
      Squamous Cell Papilloma                                       2 (67%)                                                         
   Pancreas                                           (49)         (49)         (49)         (46)                                   
      Carcinoma, Metastatic, Uterus                    1 (2%)                                                                       
      Acinus, Adenoma                                                                         1 (2%)                                
   Salivary Glands                                    (50)         (50)         (50)         (49)                                   
   Stomach, Forestomach                               (49)         (50)         (50)         (49)                                   
   Stomach, Glandular                                 (48)         (50)         (50)         (48)                                   
   Tongue                                             (2)          (3)                       (2)                                    
      Squamous Cell Carcinoma                          2 (100%)     1 (33%)                                                         
   Tooth                                              (1)                       (2)                                                 
      Adamantinoma Malignant                           1 (100%)                                                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Heart                                              (50)         (50)         (50)         (49)                                   
      Schwannoma Malignant                                                       1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    

                                                             Page   2                                                               
NTP Experiment-Test: 05182-03  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                          PHENOLPHTHALEIN                                      Date: 04/04/96  
Route: DOSED FEED                                                                                                 Time: 03:10:03  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS FEMALE                   0 PPM        12000        25000        50000                                     
                                                                PPM          PPM          PPM                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Cortex                                     (50)         (50)         (49)         (49)                                   
      Adenoma                                          2 (4%)       1 (2%)       1 (2%)       2 (4%)                                
   Adrenal Medulla                                    (50)         (50)         (50)         (49)                                   
      Pheochromocytoma Malignant                                    1 (2%)       1 (2%)                                             
      Pheochromocytoma Benign                          2 (4%)       9 (18%)      9 (18%)      2 (4%)                                
      Bilateral, Pheochromocytoma Benign               1 (2%)       2 (4%)                                                          
   Islets, Pancreatic                                 (49)         (49)         (49)         (47)                                   
      Adenoma                                          2 (4%)                    1 (2%)       1 (2%)                                
      Carcinoma                                        3 (6%)                                 1 (2%)                                
   Pituitary Gland                                    (50)         (49)         (50)         (47)                                   
      Pars Distalis, Adenoma                          35 (70%)     32 (65%)     29 (58%)     25 (53%)                               
      Pars Distalis, Carcinoma                         1 (2%)                                                                       
   Thyroid Gland                                      (50)         (50)         (50)         (48)                                   
      C-Cell, Adenoma                                  7 (14%)      5 (10%)      7 (14%)      7 (15%)                               
      C-Cell, Carcinoma                                1 (2%)       3 (6%)                    2 (4%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Clitoral Gland                                     (50)         (50)         (49)         (48)                                   
      Adenoma                                          9 (18%)      7 (14%)      3 (6%)       7 (15%)                               
      Carcinoma                                                                  1 (2%)       1 (2%)                                
      Bilateral, Adenoma                               1 (2%)                    1 (2%)                                             
   Ovary                                              (50)         (50)         (50)         (50)                                   
      Cystadenoma                                                   1 (2%)                                                          
      Granulosa Cell Tumor Malignant                                             1 (2%)                                             
      Granulosa Cell Tumor Benign                                   2 (4%)                                                          
      Granulosa-Theca Tumor Benign                                  1 (2%)                                                          
      Bilateral, Tubulostromal Adenoma                 1 (2%)                                                                       
   Uterus                                             (50)         (50)         (50)         (50)                                   
      Carcinoma                                        1 (2%)                                                                       
      Histiocytic Sarcoma                                           1 (2%)                                                          
      Schwannoma Malignant                                                       1 (2%)                                             
      Endometrium, Polyp Stromal                       3 (6%)       7 (14%)      5 (10%)      4 (8%)                                
      Endometrium, Polyp Stromal, Multiple             1 (2%)       1 (2%)       1 (2%)       1 (2%)                                
      Endometrium, Sarcoma Stromal                     1 (2%)                                                                       
   Vagina                                                          (1)                       (1)                                    
      Schwannoma Malignant                                                                    1 (100%)                              
____________________________________________________________________________________________________________________________________
                                                                                                                                    

                                                             Page   3                                                               
NTP Experiment-Test: 05182-03  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                          PHENOLPHTHALEIN                                      Date: 04/04/96  
Route: DOSED FEED                                                                                                 Time: 03:10:03  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS FEMALE                   0 PPM        12000        25000        50000                                     
                                                                PPM          PPM          PPM                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (50)         (50)         (50)         (50)                                   
      Histiocytic Sarcoma                              1 (2%)                                 1 (2%)                                
   Lymph Node                                         (7)          (11)         (9)          (9)                                    
      Mediastinal, Carcinoma, Metastatic, Uterus       1 (14%)                                                                      
   Lymph Node, Mandibular                             (50)         (50)         (50)         (48)                                   
   Lymph Node, Mesenteric                             (49)         (50)         (49)         (48)                                   
      Carcinoma, Metastatic, Uterus                    1 (2%)                                                                       
   Spleen                                             (50)         (50)         (50)         (49)                                   
      Fibrosarcoma                                                                            1 (2%)                                
      Histiocytic Sarcoma, Metastatic, Bone Marrow     1 (2%)                                                                       
   Thymus                                             (50)         (49)         (49)         (48)                                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Mammary Gland                                      (50)         (50)         (48)         (49)                                   
      Adenoma                                          2 (4%)                                                                       
      Carcinoma                                        3 (6%)                                 3 (6%)                                
      Fibroadenoma                                    21 (42%)     25 (50%)     11 (23%)     19 (39%)                               
      Fibroadenoma, Multiple                           9 (18%)                   6 (13%)      5 (10%)                               
   Skin                                               (50)         (50)         (49)         (50)                                   
      Lip, Basal Cell Adenoma                                                                 1 (2%)                                
      Pinna, Squamous Cell Papilloma                   1 (2%)                                                                       
      Subcutaneous Tissue, Fibroma                     1 (2%)       2 (4%)                    1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Skeletal Muscle                                                 (3)          (3)          (2)                                    
      Sarcoma                                                       1 (33%)                                                         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (50)         (50)         (50)         (50)                                   
      Cerebellum, Granular Cell Tumor Malignant        1 (2%)                                                                       
      Cerebrum, Astrocytoma Malignant                                                         2 (4%)                                
   Spinal Cord                                        (1)          (2)          (2)          (2)                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (50)         (50)         (50)         (50)                                   
      Alveolar/Bronchiolar Adenoma                     3 (6%)       3 (6%)       1 (2%)       2 (4%)                                
      Alveolar/Bronchiolar Carcinoma                                1 (2%)                                                          
      Carcinoma, Metastatic, Uterus                    1 (2%)                                                                       

                                                             Page   4                                                               
NTP Experiment-Test: 05182-03  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                          PHENOLPHTHALEIN                                      Date: 04/04/96  
Route: DOSED FEED                                                                                                 Time: 03:10:03  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS FEMALE                   0 PPM        12000        25000        50000                                     
                                                                PPM          PPM          PPM                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
RESPIRATORY SYSTEM - cont                                                                                                           
      Histiocytic Sarcoma, Metastatic, Bone Marrow     1 (2%)                                                                       
   Nose                                               (50)         (49)         (50)         (50)                                   
      Turbinate, Adenoma                               1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Zymbal's Gland                                                  (1)                       (1)                                    
      Carcinoma                                                     1 (100%)                                                        
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (50)         (50)         (50)         (50)                                   
      Pelvis, Transitional Epithelium, Papilloma                                              1 (2%)                                
      Renal Tubule, Adenoma                                                                   1 (2%)                                
   Urinary Bladder                                    (49)         (49)         (49)         (49)                                   
      Carcinoma, Metastatic, Uterus                    1 (2%)                                                                       
      Transitional Epithelium, Papilloma                                                      1 (2%)                                
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SYSTEMIC LESIONS                                                                                                                   

   Multiple Organs                                   *(50)        *(50)        *(50)        *(50)                                   
      Histiocytic Sarcoma                              1 (2%)       1 (2%)                    1 (2%)                                
      Leukemia Mononuclear                            21 (42%)     21 (42%)     17 (34%)     14 (28%)                               
____________________________________________________________________________________________________________________________________

                                                                                                                                    
     *   Number of animals with any tissue examined microscopically                                                                 

                                                             Page   5                                                               
NTP Experiment-Test: 05182-03  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                          PHENOLPHTHALEIN                                      Date: 04/04/96  
Route: DOSED FEED                                                                                                 Time: 03:10:03  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS FEMALE                   0 PPM        12000        25000        50000                                     
                                                                PPM          PPM          PPM                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
TUMOR SUMMARY                                                                                                                       
                                                                                                                                    
   Total Animals with Primary Neoplasms (b)            49          50          50          49                                       
     Total Primary Neoplasms                          138         133          98         108                                       
                                                                                                                                    
   Total Animals with Benign Neoplasms                 43          49          42          41                                       
     Total Benign Neoplasms                           102         102          76          82                                       
                                                                                                                                    
   Total Animals with Malignant Neoplasms              30          25          21          23                                       
     Total Malignant Neoplasms                         36          31          22          26                                       
                                                                                                                                    
   Total Animals with Metastatic Neoplasms              2                                                                           
     Total Metastatic Neoplasm                          8                                                                           
                                                                                                                                    
   Total Animals with Malignant Neoplasms                                                                                           
   Uncertain Primary Site                                                                                                           
                                                                                                                                    
   Total Animals with Neoplasms Uncertain-                                                                                          
   Benign or Malignant                                                                                                              
     Total Uncertain Neoplasms                                                                                                      
                                                                                                                                    

____________________________________________________________________________________________________________________________________
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Primary tumors: all tumors except metastatic tumors                                                                              

                                                             Page   6                                                               
NTP Experiment-Test: 05182-03  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                          PHENOLPHTHALEIN                                      Date: 04/04/96  
Route: DOSED FEED                                                                                                 Time: 03:10:03  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     0 PPM        12000        25000        50000                                     
                                                                PPM          PPM          PPM                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
DISPOSITION SUMMARY                                                                                                                 

  Animals Initially in Study                          50           50           50           50                                     
  Early Deaths                                                                                                                      
    Moribund Sacrifice                                15           15           13           16                                     
    Natural Death                                     14           20           22           21                                     
  Survivors                                                                                                                         
    Terminal Sacrifice                                21           15           14           13                                     
    Natural Death                                                                1                                                  

  Animals Examined Microscopically                    50           50           50           50                                     
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Intestine Large, Colon                             (48)         (49)         (49)         (48)                                   
   Intestine Large, Rectum                            (48)         (49)         (50)         (50)                                   
   Intestine Large, Cecum                             (44)         (41)         (44)         (40)                                   
   Intestine Small, Duodenum                          (47)         (50)         (49)         (47)                                   
   Intestine Small, Jejunum                           (47)         (41)         (47)         (42)                                   
   Intestine Small, Ileum                             (44)         (40)         (40)         (41)                                   
   Liver                                              (50)         (50)         (50)         (50)                                   
      Hepatocellular Adenoma                           1 (2%)       3 (6%)                    1 (2%)                                
      Hepatocellular Adenoma, Multiple                                                        1 (2%)                                
      Histiocytic Sarcoma                                                        1 (2%)                                             
   Mesentery                                          (20)         (7)          (3)          (3)                                    
      Histiocytic Sarcoma                                                        1 (33%)                                            
   Oral Mucosa                                        (1)                       (1)                                                 
      Pharyngeal, Squamous Cell Carcinoma                                        1 (100%)                                           
      Pharyngeal, Squamous Cell Papilloma              1 (100%)                                                                     
   Pancreas                                           (50)         (50)         (50)         (47)                                   
      Histiocytic Sarcoma                                                        1 (2%)                                             
      Acinus, Adenoma                                                            2 (4%)       1 (2%)                                
      Acinus, Adenoma, Multiple                        1 (2%)                                                                       
   Salivary Glands                                    (50)         (49)         (49)         (49)                                   
   Stomach, Forestomach                               (50)         (50)         (50)         (49)                                   
   Stomach, Glandular                                 (50)         (50)         (50)         (49)                                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Heart                                              (50)         (49)         (50)         (50)                                   
      Schwannoma Malignant                                                       1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    

                                                             Page   7                                                               
NTP Experiment-Test: 05182-03  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                          PHENOLPHTHALEIN                                      Date: 04/04/96  
Route: DOSED FEED                                                                                                 Time: 03:10:03  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     0 PPM        12000        25000        50000                                     
                                                                PPM          PPM          PPM                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Cortex                                     (50)         (50)         (50)         (50)                                   
      Adenoma                                          1 (2%)                                                                       
   Adrenal Medulla                                    (50)         (50)         (50)         (50)                                   
      Pheochromocytoma Malignant                       1 (2%)       1 (2%)                    2 (4%)                                
      Pheochromocytoma Benign                         14 (28%)     15 (30%)     15 (30%)     19 (38%)                               
      Bilateral, Pheochromocytoma Malignant                                      1 (2%)                                             
      Bilateral, Pheochromocytoma Benign               3 (6%)      19 (38%)     19 (38%)     15 (30%)                               
   Islets, Pancreatic                                 (50)         (50)         (50)         (48)                                   
      Adenoma                                          3 (6%)       2 (4%)                    1 (2%)                                
      Carcinoma                                        1 (2%)       2 (4%)       1 (2%)       2 (4%)                                
   Parathyroid Gland                                  (41)         (48)         (49)         (46)                                   
      Adenoma                                                       1 (2%)                                                          
   Pituitary Gland                                    (50)         (50)         (50)         (50)                                   
      Pars Distalis, Adenoma                          13 (26%)     11 (22%)     16 (32%)     11 (22%)                               
      Pars Intermedia, Adenoma                         1 (2%)                                                                       
   Thyroid Gland                                      (50)         (50)         (49)         (49)                                   
      Bilateral, C-Cell, Adenoma                       1 (2%)                                                                       
      Bilateral, Follicular Cell, Adenoma                           1 (2%)                                                          
      C-Cell, Adenoma                                  8 (16%)      2 (4%)       3 (6%)       4 (8%)                                
      C-Cell, Carcinoma                                                          1 (2%)       2 (4%)                                
      Follicular Cell, Adenoma                                                   2 (4%)       3 (6%)                                
      Follicular Cell, Carcinoma                       1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Epididymis                                         (50)         (50)         (50)         (50)                                   
   Preputial Gland                                    (50)         (49)         (50)         (49)                                   
      Adenoma                                          4 (8%)       4 (8%)       4 (8%)       4 (8%)                                
      Carcinoma                                                     2 (4%)       2 (4%)                                             
      Bilateral, Adenoma                               1 (2%)                                                                       
      Bilateral, Carcinoma                                          1 (2%)                                                          
   Prostate                                           (50)         (50)         (50)         (50)                                   
      Adenoma                                          2 (4%)                                                                       
   Seminal Vesicle                                    (50)         (50)         (50)         (50)                                   
   Testes                                             (50)         (50)         (50)         (50)                                   
      Bilateral, Interstitial Cell, Adenoma           42 (84%)     42 (84%)     46 (92%)     45 (90%)                               
      Interstitial Cell, Adenoma                       4 (8%)       4 (8%)       3 (6%)       4 (8%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    

                                                             Page   8                                                               
NTP Experiment-Test: 05182-03  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                          PHENOLPHTHALEIN                                      Date: 04/04/96  
Route: DOSED FEED                                                                                                 Time: 03:10:03  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     0 PPM        12000        25000        50000                                     
                                                                PPM          PPM          PPM                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (48)         (50)         (50)         (49)                                   
   Lymph Node                                         (17)         (22)         (27)         (20)                                   
      Mediastinal, Carcinoma, Metastatic, Kidney                                              1 (5%)                                
      Renal, Carcinoma, Metastatic, Kidney                                                    1 (5%)                                
   Lymph Node, Mandibular                             (50)         (49)         (49)         (49)                                   
   Lymph Node, Mesenteric                             (50)         (50)         (47)         (48)                                   
      Histiocytic Sarcoma                                                        1 (2%)                                             
   Spleen                                             (50)         (50)         (50)         (49)                                   
      Fibrosarcoma                                                  1 (2%)                                                          
      Hemangioma                                                                 1 (2%)                                             
      Histiocytic Sarcoma                                                        1 (2%)                                             
   Thymus                                             (50)         (49)         (47)         (47)                                   
      Histiocytic Sarcoma                                                        1 (2%)                                             
      Thymoma Benign                                                1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Mammary Gland                                      (43)         (47)         (48)         (47)                                   
      Adenoma                                          1 (2%)                    1 (2%)                                             
      Fibroadenoma                                     5 (12%)      2 (4%)       2 (4%)       1 (2%)                                
      Fibroadenoma, Multiple                           1 (2%)                                                                       
   Skin                                               (49)         (50)         (50)         (50)                                   
      Basal Cell Adenoma                               2 (4%)                    1 (2%)                                             
      Keratoacanthoma                                  4 (8%)       2 (4%)       3 (6%)       1 (2%)                                
      Squamous Cell Carcinoma                                       1 (2%)                                                          
      Pinna, Schwannoma Malignant                      1 (2%)                                 2 (4%)                                
      Subcutaneous Tissue, Fibroma                     2 (4%)       2 (4%)       1 (2%)       2 (4%)                                
      Subcutaneous Tissue, Fibroma, Multiple           1 (2%)                                                                       
      Subcutaneous Tissue, Histiocytic Sarcoma                                   1 (2%)                                             
      Subcutaneous Tissue, Schwannoma Malignant        1 (2%)                                 1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Bone                                               (50)         (50)         (50)         (50)                                   
      Cranium, Osteosarcoma                                                                   1 (2%)                                
   Skeletal Muscle                                    (2)          (5)          (4)          (1)                                    
      Osteosarcoma                                                               1 (25%)                                            
____________________________________________________________________________________________________________________________________
                                                                                                                                    

                                                             Page   9                                                               
NTP Experiment-Test: 05182-03  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                          PHENOLPHTHALEIN                                      Date: 04/04/96  
Route: DOSED FEED                                                                                                 Time: 03:10:03  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     0 PPM        12000        25000        50000                                     
                                                                PPM          PPM          PPM                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (50)         (50)         (50)         (50)                                   
      Cerebrum, Oligodendroglioma Malignant            1 (2%)                                                                       
   Spinal Cord                                        (2)          (3)          (3)                                                 
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (50)         (50)         (50)         (50)                                   
      Alveolar/Bronchiolar Adenoma                     1 (2%)       1 (2%)                    1 (2%)                                
      Alveolar/Bronchiolar Carcinoma                                1 (2%)                                                          
      Carcinoma, Metastatic, Kidney                                                           1 (2%)                                
      Chordoma, Metastatic, Uncertain Primary Site                  1 (2%)                                                          
      Histiocytic Sarcoma                                                        1 (2%)                                             
      Osteosarcoma, Metastatic, Bone                                                          1 (2%)                                
      Osteosarcoma, Metastatic, Skeletal Muscle                                  1 (2%)                                             
   Nose                                               (50)         (50)         (50)         (50)                                   
      Squamous Cell Carcinoma, Metastatic, Oral                                                                                     
          Mucosa                                                                 1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Zymbal's Gland                                     (1)                       (1)          (2)                                    
      Adenoma                                                                    1 (100%)                                           
      Carcinoma                                        1 (100%)                               2 (100%)                              
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (50)         (50)         (50)         (50)                                   
      Liposarcoma                                      1 (2%)                                                                       
      Renal Tubule, Adenoma                                         4 (8%)       2 (4%)       6 (12%)                               
      Renal Tubule, Carcinoma                                       1 (2%)       1 (2%)       2 (4%)                                
      Renal Tubule, Oncocytoma Benign                                                         1 (2%)                                
      Transitional Epithelium, Carcinoma                                         1 (2%)                                             
   Urinary Bladder                                    (49)         (50)         (50)         (50)                                   
      Transitional Epithelium, Carcinoma               1 (2%)                                                                       
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SYSTEMIC LESIONS                                                                                                                   

   Multiple Organs                                   *(50)        *(50)        *(50)        *(50)                                   
      Histiocytic Sarcoma                                                        1 (2%)                                             
      Leukemia Mononuclear                            31 (62%)     27 (54%)     24 (48%)     29 (58%)                               
      Mesothelioma Malignant                           2 (4%)       2 (4%)                    2 (4%)                                
                                                                                                                                    
     *   Number of animals with any tissue examined microscopically                                                                 

                                                             Page  10                                                               
NTP Experiment-Test: 05182-03  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                          PHENOLPHTHALEIN                                      Date: 04/04/96  
Route: DOSED FEED                                                                                                 Time: 03:10:03  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     0 PPM        12000        25000        50000                                     
                                                                PPM          PPM          PPM                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
 SYSTEMIC LESIONS - cont                                                                                                            

   Multiple Organs                                   *(50)        *(50)        *(50)        *(50)                                   
____________________________________________________________________________________________________________________________________

                                                             Page  11                                                               
NTP Experiment-Test: 05182-03  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                          PHENOLPHTHALEIN                                      Date: 04/04/96  
Route: DOSED FEED                                                                                                 Time: 03:10:03  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     0 PPM        12000        25000        50000                                     
                                                                PPM          PPM          PPM                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
TUMOR SUMMARY                                                                                                                       
                                                                                                                                    
   Total Animals with Primary Neoplasms (b)            49          50          50          50                                       
     Total Primary Neoplasms                          159         155         157         166                                       
                                                                                                                                    
   Total Animals with Benign Neoplasms                 47          50          49          50                                       
     Total Benign Neoplasms                           117         116         122         121                                       
                                                                                                                                    
   Total Animals with Malignant Neoplasms              35          36          31          33                                       
     Total Malignant Neoplasms                         42          39          35          45                                       
                                                                                                                                    
   Total Animals with Metastatic Neoplasms              1           2           2           4                                       
     Total Metastatic Neoplasm                          3          14           2           7                                       
                                                                                                                                    
   Total Animals with Malignant Neoplasms                           1                                                               
   Uncertain Primary Site                                                                                                           
                                                                                                                                    
   Total Animals with Neoplasms Uncertain-                                                                                          
   Benign or Malignant                                                                                                              
     Total Uncertain Neoplasms                                                                                                      
                                                                                                                                    

____________________________________________________________________________________________________________________________________
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Primary tumors: all tumors except metastatic tumors                                                                              

                                                             Page  12                                                               
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