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TDMS Study 05182-03 Pathology Tables

NTP                                        STATISTICAL ANALYSIS OF PRIMARY TUMORS                              REPORT: PEIRPT08     
LAB: TSI Mason Research                                     PHENOLPHTHALEIN                                    DATE: 04/04/96       
EXPERIMENT: 05182 TEST: 03                                                                                     TIME: 03:25:49       
TEST TYPE:  CHRONIC                             CAGES FROM 0000 TO LAST CAGE                                   PAGE:       1        
CONT: N01-ES-05302                              ROUTE: DOSED FEED                                              NTP C#: 55798B       
PATHOLOGIST: VOELKER, FRANK                  KOVATCH, ROBERT                                                   CAS: 77-09-8         
------------------------------------------------------------------------------------------------------------------------------------
               REASONS FOR REMOVAL:    ALL                                                                                          
               REMOVAL DATE RANGE:     ALL                                                                                          
               TREATMENT GROUPS:       INCLUDE ALL                                                                                  
NTP                                        STATISTICAL ANALYSIS OF PRIMARY TUMORS                              REPORT: PEIRPT08     
LAB: TSI Mason Research                                     PHENOLPHTHALEIN                                    DATE: 04/04/96       
EXPERIMENT: 05182 TEST: 03                                                                                     TIME: 03:25:49       
TEST TYPE:  CHRONIC                             CAGES FROM 0000 TO LAST CAGE                                                        
CONT: N01-ES-05302                              ROUTE: DOSED FEED                                              NTP C#: 55798B       
PATHOLOGIST: VOELKER, FRANK                  KOVATCH, ROBERT                                                   CAS: 77-09-8         
                                                    RATS(FISCHER344)
                                              ----------------------------
             FOR ALL DOSES THE TUMOR RATES IN THE FOLLOWING TISSUES/ORGANS ARE BASED ON NUMBER OF TISSUES EXAMINED.
             IN OTHER TISSUES/ORGANS, RATES ARE BASED ON NUMBER OF ANIMALS NECROPSIED.
                                                    ----------------
                                                    Adrenal Cortex
                                                    Adrenal Medulla
                                                    Bone Marrow
                                                    Brain
                                                    Clitoral Gland
                                                    Clitoral/Preputial Gland
                                                    Epididymis
                                                    Heart
                                                    Islets, Pancreatic
                                                    Kidney
                                                    Liver
                                                    Lung
                                                    Nose
                                                    Ovary
                                                    Pancreas
                                                    Parathyroid Gland
                                                    Pituitary Gland
                                                    Preputial Gland
                                                    Prostate
                                                    Salivary Glands
                                                    Spleen
                                                    Testes
                                                    Thymus
                                                    Thyroid Gland
                                                    Urinary Bladder
NTP                                        STATISTICAL ANALYSIS OF PRIMARY TUMORS                              REPORT: PEIRPT08     
LAB: TSI Mason Research                                     PHENOLPHTHALEIN                                    DATE: 04/04/96       
EXPERIMENT: 05182 TEST: 03                                                                                     TIME: 03:25:49       
TEST TYPE:  CHRONIC                             CAGES FROM 0000 TO LAST CAGE                                                        
CONT: N01-ES-05302                              ROUTE: DOSED FEED                                              NTP C#: 55798B       
PATHOLOGIST: VOELKER, FRANK                  KOVATCH, ROBERT                                                   CAS: 77-09-8         
                                     SUMMARY OF STATISTICALLY SIGNIFICANT (P<=.05) RESULTS
                                        IN THE ANALYSIS OF THE STUDY OF PHENOLPHTHALEIN
              ====================================================================================================
                                                           MALE RATS
                                                          -------------
                  ORGAN                               MORPHOLOGY
                 -------                             ------------
              Adrenal Medulla               Pheochromocytoma Benign
                                            Pheochromocytoma: Benign, Complex, Malignant, NOS
              Kidney: Renal Tubule          Adenoma
                                            Carcinoma or Adenoma
              Mammary Gland                 Fibroadenoma
                                            Fibroma, Fibroadenoma or Adenoma
                                            Fibroma, Fibroadenoma, Carcinoma, or Adenoma
              Thyroid Gland: C-Cell         Adenoma
                                            Carcinoma
                                            Carcinoma or Adenoma
              Thyroid Gland: Follicular Cell
                                            Adenoma
              ====================================================================================================
                                                           FEMALE RATS
                                                          -------------
                  ORGAN                               MORPHOLOGY
                 -------                             ------------
              Adrenal Medulla               Pheochromocytoma Benign
                                            Pheochromocytoma: Benign, Complex, Malignant, NOS
              Brain                         Astrocytoma Malignant
                                            Oligodendroglioma, Glioma, or Astrocytoma
              Clitoral/Preputial Gland      Adenoma
              Islets, Pancreatic            Carcinoma or Adenoma
              Mammary Gland                 Carcinoma or Adenoma
                                            Fibroadenoma
                                            Fibroma, Fibroadenoma or Adenoma
                                            Fibroma, Fibroadenoma, Carcinoma, or Adenoma
              Pituitary Gland: Pars Distalis or Unspecified Site
                                            Adenoma
                                            Carcinoma or Adenoma
              All Organs                    Leukemia: Lymphocytic, Monocytic, Mononuclear, or Undifferentiated
                                            Benign Tumors
                                            Malignant Tumors
              ====================================================================================================
         DATE: 04/04/96                     EXPERIMENT: 05182 TEST: 03                                                 PAGE   1
                             STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- PHENOLPHTHALEIN
                                                 TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   0 PPM        12000        25000        50000     |   0 PPM        12000        25000        50000     |
|                       |                PPM          PPM          PPM       |                PPM          PPM          PPM       |
|=================================================================================================================================|
|                                                                                                                                 |
|Adrenal Cortex                                                                                                                   |
|     Adenoma                                                                                                                     |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  1/50 (2%)    0/50 (0%)    0/50 (0%)    0/50 (0%)  |  2/50 (4%)    1/50 (2%)    1/49 (2%)    2/49 (4%)  |
|ADJUSTED (b)           |   4.8%         0.0%         0.0%         0.0%      |   6.7%         2.6%         3.1%         5.3%      |
|TERMINAL (d)           |  1/21 (5%)    0/15 (0%)    0/15 (0%)    0/13 (0%)  |  2/30 (7%)    1/38 (3%)    1/32 (3%)    2/38 (5%)  |
|FIRST INCIDENCE (DAYS) |   729 (T)      ---          ---          ---       |   735 (T)      735 (T)      735 (T)      735 (T)   |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.364N     P=0.567N     P=0.567N     P=0.596N   |  P=0.608N     P=0.417N     P=0.477N     P=0.607N   |
|INCIDENTAL TUMOR       |  P=0.364N     P=0.567N     P=0.567N     P=0.596N   |  P=0.608N     P=0.417N     P=0.477N     P=0.607N   |
|LOGISTIC REGRESSION    |  P=0.364N     P=0.567N     P=0.567N     P=0.596N   |  P=0.608N     P=0.417N     P=0.477N     P=0.607N   |
|COCHRAN-ARMITAGE       |  P=0.309N                                          |  P=0.545                                           |
|FISHER EXACT           |               P=0.500N     P=0.500N     P=0.500N   |               P=0.500N     P=0.508N     P=0.684    |
|=================================================================================================================================|
|                                                                                                                                 |
|Adrenal Medulla                                                                                                                  |
|     Pheochromocytoma Benign                                                                                                     |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            | 17/50 (34%)  34/50 (68%)  34/50 (68%)  34/50 (68%) |  3/50 (6%)   11/50 (22%)   9/50 (18%)   2/49 (4%)  |
|ADJUSTED (b)           |  62.1%        88.6%        93.7%        87.0%      |  10.0%        25.8%        23.7%         5.3%      |
|TERMINAL (d)           | 11/21 (52%)  11/15 (73%)  13/15 (87%)   9/13 (69%) |  3/30 (10%)   7/38 (18%)   5/32 (16%)   2/38 (5%)  |
|FIRST INCIDENCE (DAYS) |   608          485          372          528       |   735 (T)      549          608          735 (T)   |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.003 **   P<0.001 **   P<0.001 **   P<0.001 ** |  P=0.138N     P=0.060      P=0.088      P=0.392N   |
|INCIDENTAL TUMOR       |  P=0.007 **   P=0.001 **   P=0.002 **   P=0.002 ** |  P=0.262N     P=0.033 *    P=0.082      P=0.392N   |
|LOGISTIC REGRESSION    |  P=0.006 **   P<0.001 **   P<0.001 **   P=0.001 ** |  P=0.197N     P=0.031 *    P=0.074      P=0.392N   |
|COCHRAN-ARMITAGE       |  P=0.003 **                                        |  P=0.207N                                          |
|FISHER EXACT           |               P<0.001 **   P<0.001 **   P<0.001 ** |               P=0.020 *    P=0.061      P=0.510N   |
|=================================================================================================================================|
         DATE: 04/04/96                     EXPERIMENT: 05182 TEST: 03                                                 PAGE   2
                             STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- PHENOLPHTHALEIN
                                                 TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   0 PPM        12000        25000        50000     |   0 PPM        12000        25000        50000     |
|                       |                PPM          PPM          PPM       |                PPM          PPM          PPM       |
|=================================================================================================================================|
|                                                                                                                                 |
|Adrenal Medulla                                                                                                                  |
|     Pheochromocytoma Malignant                                                                                                  |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  1/50 (2%)    1/50 (2%)    1/50 (2%)    2/50 (4%)  |  0/50 (0%)    1/50 (2%)    1/50 (2%)    0/49 (0%)  |
|ADJUSTED (b)           |   2.0%         2.5%         2.9%        13.1%      |   0.0%         2.6%         2.1%         0.0%      |
|TERMINAL (d)           |  0/21 (0%)    0/15 (0%)    0/15 (0%)    1/13 (8%)  |  0/30 (0%)    1/38 (3%)    0/32 (0%)    0/38 (0%)  |
|FIRST INCIDENCE (DAYS) |   330          591          645          717       |   ---          735 (T)      568          ---       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.332      P=0.746N     P=0.737N     P=0.413    |  P=0.579N     P=0.547      P=0.517        (e)      |
|INCIDENTAL TUMOR       |  P=0.202      P=0.575      P=0.682      P=0.276    |  P=0.639N     P=0.547      P=0.536        (e)      |
|LOGISTIC REGRESSION    |  P=0.287      P=0.591      P=0.686      P=0.418    |  P=0.587N     P=0.547      P=0.412        (e)      |
|COCHRAN-ARMITAGE       |  P=0.350                                           |  P=0.595N                                          |
|FISHER EXACT           |               P=0.753N     P=0.753N     P=0.500    |               P=0.500      P=0.500        (e)      |
|=================================================================================================================================|
|                                                                                                                                 |
|Adrenal Medulla                                                                                                                  |
|     Pheochromocytoma: Benign, Complex, Malignant, NOS                                                                           |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            | 18/50 (36%)  35/50 (70%)  35/50 (70%)  35/50 (70%) |  3/50 (6%)   12/50 (24%)  10/50 (20%)   2/49 (4%)  |
|ADJUSTED (b)           |  62.9%        88.9%        93.9%        90.3%      |  10.0%        28.2%        25.3%         5.3%      |
|TERMINAL (d)           | 11/21 (52%)  11/15 (73%)  13/15 (87%)  10/13 (77%) |  3/30 (10%)   8/38 (21%)   5/32 (16%)   2/38 (5%)  |
|FIRST INCIDENCE (DAYS) |   330          485          372          528       |   735 (T)      549          568          735 (T)   |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.003 **   P<0.001 **   P<0.001 **   P<0.001 ** |  P=0.130N     P=0.040 *    P=0.058      P=0.392N   |
|INCIDENTAL TUMOR       |  P=0.004 **   P<0.001 **   P=0.001 **   P<0.001 ** |  P=0.254N     P=0.021 *    P=0.052      P=0.392N   |
|LOGISTIC REGRESSION    |  P=0.005 **   P<0.001 **   P<0.001 **   P=0.001 ** |  P=0.189N     P=0.019 *    P=0.041 *    P=0.392N   |
|COCHRAN-ARMITAGE       |  P=0.003 **                                        |  P=0.195N                                          |
|FISHER EXACT           |               P<0.001 **   P<0.001 **   P<0.001 ** |               P=0.011 *    P=0.036 *    P=0.510N   |
|=================================================================================================================================|
         DATE: 04/04/96                     EXPERIMENT: 05182 TEST: 03                                                 PAGE   3
                             STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- PHENOLPHTHALEIN
                                                 TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   0 PPM        12000        25000        50000     |   0 PPM        12000        25000        50000     |
|                       |                PPM          PPM          PPM       |                PPM          PPM          PPM       |
|=================================================================================================================================|
|                                                                                                                                 |
|Brain                                                                                                                            |
|     Astrocytoma Malignant                                                                                                       |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  0/50 (0%)    0/50 (0%)    0/50 (0%)    0/50 (0%)  |  0/50 (0%)    0/50 (0%)    0/50 (0%)    2/50 (4%)  |
|ADJUSTED (b)           |   0.0%         0.0%         0.0%         0.0%      |   0.0%         0.0%         0.0%         4.6%      |
|TERMINAL (d)           |  0/21 (0%)    0/15 (0%)    0/15 (0%)    0/13 (0%)  |  0/30 (0%)    0/38 (0%)    0/32 (0%)    1/38 (3%)  |
|FIRST INCIDENCE (DAYS) |   ---          ---          ---          ---       |   ---          ---          ---          271       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |    (e)          (e)          (e)          (e)      |  P=0.052        (e)          (e)        P=0.266    |
|INCIDENTAL TUMOR       |    (e)          (e)          (e)          (e)      |  P=0.217        (e)          (e)        P=0.547    |
|LOGISTIC REGRESSION    |    (e)          (e)          (e)          (e)      |  P=0.093        (e)          (e)        P=0.258    |
|COCHRAN-ARMITAGE       |    (e)                                             |  P=0.046 *                                         |
|FISHER EXACT           |                 (e)          (e)          (e)      |                 (e)          (e)        P=0.247    |
|=================================================================================================================================|
|                                                                                                                                 |
|Brain                                                                                                                            |
|     Oligodendroglioma, Glioma, or Astrocytoma                                                                                   |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  1/50 (2%)    0/50 (0%)    0/50 (0%)    0/50 (0%)  |  0/50 (0%)    0/50 (0%)    0/50 (0%)    2/50 (4%)  |
|ADJUSTED (b)           |   2.6%         0.0%         0.0%         0.0%      |   0.0%         0.0%         0.0%         4.6%      |
|TERMINAL (d)           |  0/21 (0%)    0/15 (0%)    0/15 (0%)    0/13 (0%)  |  0/30 (0%)    0/38 (0%)    0/32 (0%)    1/38 (3%)  |
|FIRST INCIDENCE (DAYS) |   571          ---          ---          ---       |   ---          ---          ---          271       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.292N     P=0.485N     P=0.466N     P=0.475N   |  P=0.052        (e)          (e)        P=0.266    |
|INCIDENTAL TUMOR       |  P=0.325N     P=0.425N     P=0.519N     P=0.500N   |  P=0.217        (e)          (e)        P=0.547    |
|LOGISTIC REGRESSION    |  P=0.348N     P=0.545N     P=0.533N     P=0.571N   |  P=0.093        (e)          (e)        P=0.258    |
|COCHRAN-ARMITAGE       |  P=0.309N                                          |  P=0.046 *                                         |
|FISHER EXACT           |               P=0.500N     P=0.500N     P=0.500N   |                 (e)          (e)        P=0.247    |
|=================================================================================================================================|
         DATE: 04/04/96                     EXPERIMENT: 05182 TEST: 03                                                 PAGE   4
                             STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- PHENOLPHTHALEIN
                                                 TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   0 PPM        12000        25000        50000     |   0 PPM        12000        25000        50000     |
|                       |                PPM          PPM          PPM       |                PPM          PPM          PPM       |
|=================================================================================================================================|
|                                                                                                                                 |
|Clitoral/Preputial Gland                                                                                                         |
|     Adenoma                                                                                                                     |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  5/50 (10%)   4/49 (8%)    4/50 (8%)    4/49 (8%)  | 10/50 (20%)   7/50 (14%)   4/49 (8%)    7/48 (15%) |
|ADJUSTED (b)           |  21.9%        13.5%        18.4%        22.9%      |  32.2%        17.8%        12.5%        18.9%      |
|TERMINAL (d)           |  4/21 (19%)   0/15 (0%)    1/15 (7%)    2/13 (15%) |  9/30 (30%)   6/38 (16%)   4/32 (13%)   7/37 (19%) |
|FIRST INCIDENCE (DAYS) |   671          485          416          585       |   723          705          735 (T)      735 (T)   |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.543      P=0.613N     P=0.625      P=0.561    |  P=0.162N     P=0.142N     P=0.053N     P=0.150N   |
|INCIDENTAL TUMOR       |  P=0.462N     P=0.504N     P=0.468N     P=0.581N   |  P=0.198N     P=0.168N     P=0.054N     P=0.192N   |
|LOGISTIC REGRESSION    |  P=0.439N     P=0.502N     P=0.472N     P=0.539N   |  P=0.176N     P=0.157N     P=0.044N*    P=0.162N   |
|COCHRAN-ARMITAGE       |  P=0.458N                                          |  P=0.275N                                          |
|FISHER EXACT           |               P=0.513N     P=0.500N     P=0.513N   |               P=0.298N     P=0.080N     P=0.330N   |
|=================================================================================================================================|
|                                                                                                                                 |
|Clitoral/Preputial Gland                                                                                                         |
|     Carcinoma                                                                                                                   |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  0/50 (0%)    3/49 (6%)    2/50 (4%)    0/49 (0%)  |  0/50 (0%)    0/50 (0%)    1/49 (2%)    1/48 (2%)  |
|ADJUSTED (b)           |   0.0%        15.8%        13.3%         0.0%      |   0.0%         0.0%         3.1%         2.7%      |
|TERMINAL (d)           |  0/21 (0%)    2/15 (13%)   2/15 (13%)   0/13 (0%)  |  0/30 (0%)    0/38 (0%)    1/32 (3%)    1/37 (3%)  |
|FIRST INCIDENCE (DAYS) |   ---          618          729 (T)      ---       |   ---          ---          735 (T)      735 (T)   |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.498N     P=0.092      P=0.166        (e)      |  P=0.257        (e)        P=0.513      P=0.542    |
|INCIDENTAL TUMOR       |  P=0.523N     P=0.099      P=0.166        (e)      |  P=0.257        (e)        P=0.513      P=0.542    |
|LOGISTIC REGRESSION    |  P=0.419N     P=0.114      P=0.166        (e)      |  P=0.257        (e)        P=0.513      P=0.542    |
|COCHRAN-ARMITAGE       |  P=0.405N                                          |  P=0.225                                           |
|FISHER EXACT           |               P=0.117      P=0.247        (e)      |                 (e)        P=0.495      P=0.490    |
|=================================================================================================================================|
         DATE: 04/04/96                     EXPERIMENT: 05182 TEST: 03                                                 PAGE   5
                             STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- PHENOLPHTHALEIN
                                                 TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   0 PPM        12000        25000        50000     |   0 PPM        12000        25000        50000     |
|                       |                PPM          PPM          PPM       |                PPM          PPM          PPM       |
|=================================================================================================================================|
|                                                                                                                                 |
|Clitoral/Preputial Gland                                                                                                         |
|     Carcinoma or Adenoma                                                                                                        |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  5/50 (10%)   7/49 (14%)   5/50 (10%)   4/49 (8%)  | 10/50 (20%)   7/50 (14%)   5/49 (10%)   7/48 (15%) |
|ADJUSTED (b)           |  21.9%        27.2%        24.2%        22.9%      |  32.2%        17.8%        15.6%        18.9%      |
|TERMINAL (d)           |  4/21 (19%)   2/15 (13%)   2/15 (13%)   2/13 (15%) |  9/30 (30%)   6/38 (16%)   5/32 (16%)   7/37 (19%) |
|FIRST INCIDENCE (DAYS) |   671          485          416          585       |   723          705          735 (T)      735 (T)   |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.491N     P=0.263      P=0.466      P=0.561    |  P=0.172N     P=0.142N     P=0.097N     P=0.150N   |
|INCIDENTAL TUMOR       |  P=0.385N     P=0.355      P=0.629N     P=0.581N   |  P=0.209N     P=0.168N     P=0.099N     P=0.192N   |
|LOGISTIC REGRESSION    |  P=0.316N     P=0.375      P=0.602N     P=0.539N   |  P=0.186N     P=0.157N     P=0.083N     P=0.162N   |
|COCHRAN-ARMITAGE       |  P=0.339N                                          |  P=0.291N                                          |
|FISHER EXACT           |               P=0.365      P=0.630N     P=0.513N   |               P=0.298N     P=0.140N     P=0.330N   |
|=================================================================================================================================|
|                                                                                                                                 |
|Islets, Pancreatic                                                                                                               |
|     Adenoma                                                                                                                     |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  3/50 (6%)    2/50 (4%)    0/50 (0%)    1/48 (2%)  |  2/49 (4%)    0/49 (0%)    1/49 (2%)    1/47 (2%)  |
|ADJUSTED (b)           |  13.6%        11.9%         0.0%         2.5%      |   6.7%         0.0%         3.1%         2.6%      |
|TERMINAL (d)           |  2/21 (10%)   1/15 (7%)    0/15 (0%)    0/13 (0%)  |  2/30 (7%)    0/38 (0%)    1/32 (3%)    1/38 (3%)  |
|FIRST INCIDENCE (DAYS) |   727          715          ---          612       |   735 (T)      ---          735 (T)      735 (T)   |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.242N     P=0.644N     P=0.186N     P=0.425N   |  P=0.457N     P=0.188N     P=0.477N     P=0.417N   |
|INCIDENTAL TUMOR       |  P=0.152N     P=0.504N     P=0.101N     P=0.308N   |  P=0.457N     P=0.188N     P=0.477N     P=0.417N   |
|LOGISTIC REGRESSION    |  P=0.169N     P=0.612N     P=0.175N     P=0.311N   |  P=0.457N     P=0.188N     P=0.477N     P=0.417N   |
|COCHRAN-ARMITAGE       |  P=0.171N                                          |  P=0.518N                                          |
|FISHER EXACT           |               P=0.500N     P=0.121N     P=0.324N   |               P=0.247N     P=0.500N     P=0.516N   |
|=================================================================================================================================|
         DATE: 04/04/96                     EXPERIMENT: 05182 TEST: 03                                                 PAGE   6
                             STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- PHENOLPHTHALEIN
                                                 TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   0 PPM        12000        25000        50000     |   0 PPM        12000        25000        50000     |
|                       |                PPM          PPM          PPM       |                PPM          PPM          PPM       |
|=================================================================================================================================|
|                                                                                                                                 |
|Islets, Pancreatic                                                                                                               |
|     Carcinoma                                                                                                                   |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  1/50 (2%)    2/50 (4%)    1/50 (2%)    2/48 (4%)  |  3/49 (6%)    0/49 (0%)    0/49 (0%)    1/47 (2%)  |
|ADJUSTED (b)           |   4.8%         8.3%         3.8%        10.0%      |   9.2%         0.0%         0.0%         2.6%      |
|TERMINAL (d)           |  1/21 (5%)    0/15 (0%)    0/15 (0%)    0/13 (0%)  |  2/30 (7%)    0/38 (0%)    0/32 (0%)    1/38 (3%)  |
|FIRST INCIDENCE (DAYS) |   729 (T)      638          681          700       |   683          ---          ---          735 (T)   |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.384      P=0.428      P=0.719      P=0.389    |  P=0.222N     P=0.091N     P=0.111N     P=0.238N   |
|INCIDENTAL TUMOR       |  P=0.606      P=0.560      P=0.709N     P=0.652    |  P=0.287N     P=0.107N     P=0.121N     P=0.383N   |
|LOGISTIC REGRESSION    |  P=0.447      P=0.496      P=0.760N     P=0.462    |  P=0.254N     P=0.101N     P=0.110N     P=0.297N   |
|COCHRAN-ARMITAGE       |  P=0.431                                           |  P=0.261N                                          |
|FISHER EXACT           |               P=0.500      P=0.753N     P=0.485    |               P=0.121N     P=0.121N     P=0.324N   |
|=================================================================================================================================|
|                                                                                                                                 |
|Islets, Pancreatic                                                                                                               |
|     Carcinoma or Adenoma                                                                                                        |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  4/50 (8%)    4/50 (8%)    1/50 (2%)    3/48 (6%)  |  5/49 (10%)   0/49 (0%)    1/49 (2%)    1/47 (2%)  |
|ADJUSTED (b)           |  18.2%        19.1%         3.8%        12.2%      |  15.7%         0.0%         3.1%         2.6%      |
|TERMINAL (d)           |  3/21 (14%)   1/15 (7%)    0/15 (0%)    0/13 (0%)  |  4/30 (13%)   0/38 (0%)    1/32 (3%)    1/38 (3%)  |
|FIRST INCIDENCE (DAYS) |   727          638          681          612       |   683          ---          735 (T)      735 (T)   |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.466N     P=0.483      P=0.271N     P=0.635    |  P=0.069N     P=0.019N*    P=0.089N     P=0.063N   |
|INCIDENTAL TUMOR       |  P=0.233N     P=0.614N     P=0.128N     P=0.406N   |  P=0.089N     P=0.023N*    P=0.096N     P=0.107N   |
|LOGISTIC REGRESSION    |  P=0.344N     P=0.593      P=0.199N     P=0.525N   |  P=0.084N     P=0.022N*    P=0.086N     P=0.091N   |
|COCHRAN-ARMITAGE       |  P=0.361N                                          |  P=0.095N                                          |
|FISHER EXACT           |               P=0.643N     P=0.181N     P=0.523N   |               P=0.028N*    P=0.102N     P=0.112N   |
|=================================================================================================================================|
         DATE: 04/04/96                     EXPERIMENT: 05182 TEST: 03                                                 PAGE   7
                             STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- PHENOLPHTHALEIN
                                                 TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   0 PPM        12000        25000        50000     |   0 PPM        12000        25000        50000     |
|                       |                PPM          PPM          PPM       |                PPM          PPM          PPM       |
|=================================================================================================================================|
|                                                                                                                                 |
|Kidney: Renal Tubule                                                                                                             |
|     Adenoma                                                                                                                     |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  0/50 (0%)    4/50 (8%)    2/50 (4%)    6/50 (12%) |  0/50 (0%)    0/50 (0%)    0/50 (0%)    1/50 (2%)  |
|ADJUSTED (b)           |   0.0%        20.4%        10.6%        22.4%      |   0.0%         0.0%         0.0%         2.6%      |
|TERMINAL (d)           |  0/21 (0%)    2/15 (13%)   1/15 (7%)    1/13 (8%)  |  0/30 (0%)    0/38 (0%)    0/32 (0%)    1/38 (3%)  |
|FIRST INCIDENCE (DAYS) |   ---          577          692          542       |   ---          ---          ---          735 (T)   |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.015 *    P=0.040 *    P=0.195      P=0.017 *  |  P=0.217        (e)          (e)        P=0.547    |
|INCIDENTAL TUMOR       |  P=0.033 *    P=0.068      P=0.291      P=0.034 *  |  P=0.217        (e)          (e)        P=0.547    |
|LOGISTIC REGRESSION    |  P=0.026 *    P=0.060      P=0.233      P=0.018 *  |  P=0.217        (e)          (e)        P=0.547    |
|COCHRAN-ARMITAGE       |  P=0.023 *                                         |  P=0.197                                           |
|FISHER EXACT           |               P=0.059      P=0.247      P=0.013 *  |                 (e)          (e)        P=0.500    |
|=================================================================================================================================|
|                                                                                                                                 |
|Kidney: Renal Tubule                                                                                                             |
|     Carcinoma                                                                                                                   |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  0/50 (0%)    1/50 (2%)    1/50 (2%)    2/50 (4%)  |  0/50 (0%)    0/50 (0%)    0/50 (0%)    0/50 (0%)  |
|ADJUSTED (b)           |   0.0%         4.5%         6.3%         8.1%      |   0.0%         0.0%         0.0%         0.0%      |
|TERMINAL (d)           |  0/21 (0%)    0/15 (0%)    0/15 (0%)    0/13 (0%)  |  0/30 (0%)    0/38 (0%)    0/32 (0%)    0/38 (0%)  |
|FIRST INCIDENCE (DAYS) |   ---          693          727          652       |   ---          ---          ---          ---       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.131      P=0.467      P=0.436      P=0.231    |    (e)          (e)          (e)          (e)      |
|INCIDENTAL TUMOR       |  P=0.340      P=0.597      P=0.682      P=0.467    |    (e)          (e)          (e)          (e)      |
|LOGISTIC REGRESSION    |  P=0.156      P=0.496      P=0.446      P=0.245    |    (e)          (e)          (e)          (e)      |
|COCHRAN-ARMITAGE       |  P=0.154                                           |    (e)                                             |
|FISHER EXACT           |               P=0.500      P=0.500      P=0.247    |                 (e)          (e)          (e)      |
|=================================================================================================================================|
         DATE: 04/04/96                     EXPERIMENT: 05182 TEST: 03                                                 PAGE   8
                             STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- PHENOLPHTHALEIN
                                                 TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   0 PPM        12000        25000        50000     |   0 PPM        12000        25000        50000     |
|                       |                PPM          PPM          PPM       |                PPM          PPM          PPM       |
|=================================================================================================================================|
|                                                                                                                                 |
|Kidney: Renal Tubule                                                                                                             |
|     Carcinoma or Adenoma                                                                                                        |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  0/50 (0%)    5/50 (10%)   3/50 (6%)    7/50 (14%) |  0/50 (0%)    0/50 (0%)    0/50 (0%)    1/50 (2%)  |
|ADJUSTED (b)           |   0.0%        24.0%        16.1%        24.7%      |   0.0%         0.0%         0.0%         2.6%      |
|TERMINAL (d)           |  0/21 (0%)    2/15 (13%)   1/15 (7%)    1/13 (8%)  |  0/30 (0%)    0/38 (0%)    0/32 (0%)    1/38 (3%)  |
|FIRST INCIDENCE (DAYS) |   ---          577          692          542       |   ---          ---          ---          735 (T)   |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.011 *    P=0.020 *    P=0.084      P=0.011 *  |  P=0.217        (e)          (e)        P=0.547    |
|INCIDENTAL TUMOR       |  P=0.041 *    P=0.044 *    P=0.206      P=0.026 *  |  P=0.217        (e)          (e)        P=0.547    |
|LOGISTIC REGRESSION    |  P=0.020 *    P=0.031 *    P=0.106      P=0.009 ** |  P=0.217        (e)          (e)        P=0.547    |
|COCHRAN-ARMITAGE       |  P=0.017 *                                         |  P=0.197                                           |
|FISHER EXACT           |               P=0.028 *    P=0.121      P=0.006 ** |                 (e)          (e)        P=0.500    |
|=================================================================================================================================|
|                                                                                                                                 |
|Liver                                                                                                                            |
|     Hepatocellular Adenoma                                                                                                      |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  1/50 (2%)    3/50 (6%)    0/50 (0%)    2/50 (4%)  |  0/50 (0%)    2/50 (4%)    1/50 (2%)    1/49 (2%)  |
|ADJUSTED (b)           |   4.5%         9.4%         0.0%         8.8%      |   0.0%         5.0%         3.1%         2.6%      |
|TERMINAL (d)           |  0/21 (0%)    0/15 (0%)    0/15 (0%)    0/13 (0%)  |  0/30 (0%)    1/38 (3%)    1/32 (3%)    1/38 (3%)  |
|FIRST INCIDENCE (DAYS) |   727          577          ---          668       |   ---          705          735 (T)      735 (T)   |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.532      P=0.285      P=0.564N     P=0.409    |  P=0.551      P=0.291      P=0.513      P=0.547    |
|INCIDENTAL TUMOR       |  P=0.473N     P=0.468      P=0.318N     P=0.670N   |  P=0.479      P=0.240      P=0.513      P=0.547    |
|LOGISTIC REGRESSION    |  P=0.571      P=0.307      P=0.554N     P=0.495    |  P=0.521      P=0.262      P=0.513      P=0.547    |
|COCHRAN-ARMITAGE       |  P=0.562                                           |  P=0.499                                           |
|FISHER EXACT           |               P=0.309      P=0.500N     P=0.500    |               P=0.247      P=0.500      P=0.495    |
|=================================================================================================================================|
         DATE: 04/04/96                     EXPERIMENT: 05182 TEST: 03                                                 PAGE   9
                             STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- PHENOLPHTHALEIN
                                                 TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   0 PPM        12000        25000        50000     |   0 PPM        12000        25000        50000     |
|                       |                PPM          PPM          PPM       |                PPM          PPM          PPM       |
|=================================================================================================================================|
|                                                                                                                                 |
|Liver                                                                                                                            |
|     Hepatocellular Carcinoma or Hepatocellular Adenoma                                                                          |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  1/50 (2%)    3/50 (6%)    0/50 (0%)    2/50 (4%)  |  0/50 (0%)    3/50 (6%)    1/50 (2%)    1/49 (2%)  |
|ADJUSTED (b)           |   4.5%         9.4%         0.0%         8.8%      |   0.0%         7.2%         3.1%         2.6%      |
|TERMINAL (d)           |  0/21 (0%)    0/15 (0%)    0/15 (0%)    0/13 (0%)  |  0/30 (0%)    1/38 (3%)    1/32 (3%)    1/38 (3%)  |
|FIRST INCIDENCE (DAYS) |   727          577          ---          668       |   ---          679          735 (T)      735 (T)   |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.532      P=0.285      P=0.564N     P=0.409    |  P=0.596N     P=0.162      P=0.513      P=0.547    |
|INCIDENTAL TUMOR       |  P=0.473N     P=0.468      P=0.318N     P=0.670N   |  P=0.522      P=0.106      P=0.513      P=0.547    |
|LOGISTIC REGRESSION    |  P=0.571      P=0.307      P=0.554N     P=0.495    |  P=0.602      P=0.126      P=0.513      P=0.547    |
|COCHRAN-ARMITAGE       |  P=0.562                                           |  P=0.592                                           |
|FISHER EXACT           |               P=0.309      P=0.500N     P=0.500    |               P=0.121      P=0.500      P=0.495    |
|=================================================================================================================================|
|                                                                                                                                 |
|Liver                                                                                                                            |
|     Hepatocellular Carcinoma, Hepatocellular Adenoma, or Hepatoblastoma                                                         |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  1/50 (2%)    3/50 (6%)    0/50 (0%)    2/50 (4%)  |  0/50 (0%)    3/50 (6%)    1/50 (2%)    1/49 (2%)  |
|ADJUSTED (b)           |   4.5%         9.4%         0.0%         8.8%      |   0.0%         7.2%         3.1%         2.6%      |
|TERMINAL (d)           |  0/21 (0%)    0/15 (0%)    0/15 (0%)    0/13 (0%)  |  0/30 (0%)    1/38 (3%)    1/32 (3%)    1/38 (3%)  |
|FIRST INCIDENCE (DAYS) |   727          577          ---          668       |   ---          679          735 (T)      735 (T)   |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.532      P=0.285      P=0.564N     P=0.409    |  P=0.596N     P=0.162      P=0.513      P=0.547    |
|INCIDENTAL TUMOR       |  P=0.473N     P=0.468      P=0.318N     P=0.670N   |  P=0.522      P=0.106      P=0.513      P=0.547    |
|LOGISTIC REGRESSION    |  P=0.571      P=0.307      P=0.554N     P=0.495    |  P=0.602      P=0.126      P=0.513      P=0.547    |
|COCHRAN-ARMITAGE       |  P=0.562                                           |  P=0.592                                           |
|FISHER EXACT           |               P=0.309      P=0.500N     P=0.500    |               P=0.121      P=0.500      P=0.495    |
|=================================================================================================================================|
         DATE: 04/04/96                     EXPERIMENT: 05182 TEST: 03                                                 PAGE  10
                             STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- PHENOLPHTHALEIN
                                                 TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   0 PPM        12000        25000        50000     |   0 PPM        12000        25000        50000     |
|                       |                PPM          PPM          PPM       |                PPM          PPM          PPM       |
|=================================================================================================================================|
|                                                                                                                                 |
|Lung                                                                                                                             |
|     Alveolar/Bronchiolar Adenoma                                                                                                |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  1/50 (2%)    1/50 (2%)    0/50 (0%)    1/50 (2%)  |  3/50 (6%)    3/50 (6%)    1/50 (2%)    2/50 (4%)  |
|ADJUSTED (b)           |   4.8%         6.7%         0.0%         7.7%      |  10.0%         7.9%         3.1%         5.3%      |
|TERMINAL (d)           |  1/21 (5%)    1/15 (7%)    0/15 (0%)    1/13 (8%)  |  3/30 (10%)   3/38 (8%)    1/32 (3%)    2/38 (5%)  |
|FIRST INCIDENCE (DAYS) |   729 (T)      729 (T)      ---          729 (T)   |   735 (T)      735 (T)      735 (T)      735 (T)   |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.589      P=0.686      P=0.567N     P=0.652    |  P=0.276N     P=0.550N     P=0.281N     P=0.392N   |
|INCIDENTAL TUMOR       |  P=0.589      P=0.686      P=0.567N     P=0.652    |  P=0.276N     P=0.550N     P=0.281N     P=0.392N   |
|LOGISTIC REGRESSION    |  P=0.589      P=0.686      P=0.567N     P=0.652    |  P=0.276N     P=0.550N     P=0.281N     P=0.392N   |
|COCHRAN-ARMITAGE       |  P=0.614N                                          |  P=0.341N                                          |
|FISHER EXACT           |               P=0.753N     P=0.500N     P=0.753N   |               P=0.661N     P=0.309N     P=0.500N   |
|=================================================================================================================================|
|                                                                                                                                 |
|Lung                                                                                                                             |
|     Alveolar/Bronchiolar Carcinoma or Alveolar/Bronchiolar Adenoma                                                              |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  1/50 (2%)    2/50 (4%)    0/50 (0%)    1/50 (2%)  |  3/50 (6%)    4/50 (8%)    1/50 (2%)    2/50 (4%)  |
|ADJUSTED (b)           |   4.8%        13.3%         0.0%         7.7%      |  10.0%        10.5%         3.1%         5.3%      |
|TERMINAL (d)           |  1/21 (5%)    2/15 (13%)   0/15 (0%)    1/13 (8%)  |  3/30 (10%)   4/38 (11%)   1/32 (3%)    2/38 (5%)  |
|FIRST INCIDENCE (DAYS) |   729 (T)      729 (T)      ---          729 (T)   |   735 (T)      735 (T)      735 (T)      735 (T)   |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.623N     P=0.382      P=0.567N     P=0.652    |  P=0.225N     P=0.629      P=0.281N     P=0.392N   |
|INCIDENTAL TUMOR       |  P=0.623N     P=0.382      P=0.567N     P=0.652    |  P=0.225N     P=0.629      P=0.281N     P=0.392N   |
|LOGISTIC REGRESSION    |  P=0.623N     P=0.382      P=0.567N     P=0.652    |  P=0.225N     P=0.630      P=0.281N     P=0.392N   |
|COCHRAN-ARMITAGE       |  P=0.495N                                          |  P=0.288N                                          |
|FISHER EXACT           |               P=0.500      P=0.500N     P=0.753N   |               P=0.500      P=0.309N     P=0.500N   |
|=================================================================================================================================|
         DATE: 04/04/96                     EXPERIMENT: 05182 TEST: 03                                                 PAGE  11
                             STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- PHENOLPHTHALEIN
                                                 TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   0 PPM        12000        25000        50000     |   0 PPM        12000        25000        50000     |
|                       |                PPM          PPM          PPM       |                PPM          PPM          PPM       |
|=================================================================================================================================|
|                                                                                                                                 |
|Mammary Gland                                                                                                                    |
|     Adenoma                                                                                                                     |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #        |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  1/50 (2%)    0/50 (0%)    1/50 (2%)    0/50 (0%)  |  2/50 (4%)    0/50 (0%)    0/50 (0%)    0/50 (0%)  |
|ADJUSTED (b)           |   4.2%         0.0%         6.7%         0.0%      |   5.5%         0.0%         0.0%         0.0%      |
|TERMINAL (d)           |  0/21 (0%)    0/15 (0%)    1/15 (7%)    0/13 (0%)  |  1/30 (3%)    0/38 (0%)    0/32 (0%)    0/38 (0%)  |
|FIRST INCIDENCE (DAYS) |   715          ---          729 (T)      ---       |   594          ---          ---          ---       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.486N     P=0.557N     P=0.683      P=0.569N   |  P=0.112N     P=0.207N     P=0.226N     P=0.219N   |
|INCIDENTAL TUMOR       |  P=0.365N     P=0.403N     P=0.709N     P=0.308N   |  P=0.125N     P=0.266N     P=0.213N     P=0.304N   |
|LOGISTIC REGRESSION    |  P=0.450N     P=0.524N     P=0.737      P=0.524N   |  P=0.118N     P=0.264N     P=0.252N     P=0.239N   |
|COCHRAN-ARMITAGE       |  P=0.409N                                          |  P=0.118N                                          |
|FISHER EXACT           |               P=0.500N     P=0.753N     P=0.500N   |               P=0.247N     P=0.247N     P=0.247N   |
|=================================================================================================================================|
|                                                                                                                                 |
|Mammary Gland                                                                                                                    |
|     Carcinoma                                                                                                                   |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #        |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  0/50 (0%)    0/50 (0%)    0/50 (0%)    0/50 (0%)  |  3/50 (6%)    0/50 (0%)    0/50 (0%)    3/50 (6%)  |
|ADJUSTED (b)           |   0.0%         0.0%         0.0%         0.0%      |   8.8%         0.0%         0.0%         6.7%      |
|TERMINAL (d)           |  0/21 (0%)    0/15 (0%)    0/15 (0%)    0/13 (0%)  |  2/30 (7%)    0/38 (0%)    0/32 (0%)    1/38 (3%)  |
|FIRST INCIDENCE (DAYS) |   ---          ---          ---          ---       |   594          ---          ---          330       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |    (e)          (e)          (e)          (e)      |  P=0.461      P=0.093N     P=0.112N     P=0.612N   |
|INCIDENTAL TUMOR       |    (e)          (e)          (e)          (e)      |  P=0.519N     P=0.121N     P=0.105N     P=0.514N   |
|LOGISTIC REGRESSION    |    (e)          (e)          (e)          (e)      |  P=0.492      P=0.122N     P=0.120N     P=0.662N   |
|COCHRAN-ARMITAGE       |    (e)                                             |  P=0.438                                           |
|FISHER EXACT           |                 (e)          (e)          (e)      |               P=0.121N     P=0.121N     P=0.661N   |
|=================================================================================================================================|
         DATE: 04/04/96                     EXPERIMENT: 05182 TEST: 03                                                 PAGE  12
                             STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- PHENOLPHTHALEIN
                                                 TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   0 PPM        12000        25000        50000     |   0 PPM        12000        25000        50000     |
|                       |                PPM          PPM          PPM       |                PPM          PPM          PPM       |
|=================================================================================================================================|
|                                                                                                                                 |
|Mammary Gland                                                                                                                    |
|     Carcinoma or Adenoma                                                                                                        |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #        |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  1/50 (2%)    0/50 (0%)    1/50 (2%)    0/50 (0%)  |  4/50 (8%)    0/50 (0%)    0/50 (0%)    3/50 (6%)  |
|ADJUSTED (b)           |   4.2%         0.0%         6.7%         0.0%      |  12.0%         0.0%         0.0%         6.7%      |
|TERMINAL (d)           |  0/21 (0%)    0/15 (0%)    1/15 (7%)    0/13 (0%)  |  3/30 (10%)   0/38 (0%)    0/32 (0%)    1/38 (3%)  |
|FIRST INCIDENCE (DAYS) |   715          ---          729 (T)      ---       |   594          ---          ---          330       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.486N     P=0.557N     P=0.683      P=0.569N   |  P=0.554N     P=0.043N*    P=0.056N     P=0.435N   |
|INCIDENTAL TUMOR       |  P=0.365N     P=0.403N     P=0.709N     P=0.308N   |  P=0.325N     P=0.056N     P=0.053N     P=0.330N   |
|LOGISTIC REGRESSION    |  P=0.450N     P=0.524N     P=0.737      P=0.524N   |  P=0.542N     P=0.058N     P=0.059N     P=0.500N   |
|COCHRAN-ARMITAGE       |  P=0.409N                                          |  P=0.584N                                          |
|FISHER EXACT           |               P=0.500N     P=0.753N     P=0.500N   |               P=0.059N     P=0.059N     P=0.500N   |
|=================================================================================================================================|
|                                                                                                                                 |
|Mammary Gland                                                                                                                    |
|     Fibroadenoma                                                                                                                |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #        |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  6/50 (12%)   2/50 (4%)    2/50 (4%)    1/50 (2%)  | 30/50 (60%)  25/50 (50%)  17/50 (34%)  24/50 (48%) |
|ADJUSTED (b)           |  22.8%        10.9%        13.3%         7.7%      |  83.2%        60.6%        50.0%        58.4%      |
|TERMINAL (d)           |  3/21 (14%)   1/15 (7%)    2/15 (13%)   1/13 (8%)  | 24/30 (80%)  22/38 (58%)  15/32 (47%)  21/38 (55%) |
|FIRST INCIDENCE (DAYS) |   534          693          729 (T)      729 (T)   |   606          435          729          506       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.092N     P=0.231N     P=0.235N     P=0.131N   |  P=0.026N*    P=0.019N*    P=0.002N**   P=0.014N*  |
|INCIDENTAL TUMOR       |  P=0.049N*    P=0.138N     P=0.142N     P=0.063N   |  P=0.067N     P=0.046N*    P=0.002N**   P=0.083N   |
|LOGISTIC REGRESSION    |  P=0.041N*    P=0.138N     P=0.120N     P=0.054N   |  P=0.060N     P=0.050N*    P<0.001N**   P=0.075N   |
|COCHRAN-ARMITAGE       |  P=0.043N*                                         |  P=0.125N                                          |
|FISHER EXACT           |               P=0.134N     P=0.134N     P=0.056N   |               P=0.211N     P=0.008N**   P=0.158N   |
|=================================================================================================================================|
         DATE: 04/04/96                     EXPERIMENT: 05182 TEST: 03                                                 PAGE  13
                             STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- PHENOLPHTHALEIN
                                                 TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   0 PPM        12000        25000        50000     |   0 PPM        12000        25000        50000     |
|                       |                PPM          PPM          PPM       |                PPM          PPM          PPM       |
|=================================================================================================================================|
|                                                                                                                                 |
|Mammary Gland                                                                                                                    |
|     Fibroma, Fibroadenoma or Adenoma                                                                                            |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #        |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  7/50 (14%)   2/50 (4%)    3/50 (6%)    1/50 (2%)  | 32/50 (64%)  25/50 (50%)  17/50 (34%)  24/50 (48%) |
|ADJUSTED (b)           |  26.0%        10.9%        20.0%         7.7%      |  86.3%        60.6%        50.0%        58.4%      |
|TERMINAL (d)           |  3/21 (14%)   1/15 (7%)    3/15 (20%)   1/13 (8%)  | 25/30 (83%)  22/38 (58%)  15/32 (47%)  21/38 (55%) |
|FIRST INCIDENCE (DAYS) |   534          693          729 (T)      729 (T)   |   594          435          729          506       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.075N     P=0.162N     P=0.295N     P=0.088N   |  P=0.011N*    P=0.007N**   P<0.001N**   P=0.005N** |
|INCIDENTAL TUMOR       |  P=0.030N*    P=0.068N     P=0.143N     P=0.022N*  |  P=0.034N*    P=0.019N*    P<0.001N**   P=0.039N*  |
|LOGISTIC REGRESSION    |  P=0.030N*    P=0.084N     P=0.142N     P=0.030N*  |  P=0.047N*    P=0.021N*    P<0.001N**   P=0.033N*  |
|COCHRAN-ARMITAGE       |  P=0.030N*                                         |  P=0.070N                                          |
|FISHER EXACT           |               P=0.080N     P=0.159N     P=0.030N*  |               P=0.113N     P=0.002N**   P=0.079N   |
|=================================================================================================================================|
|                                                                                                                                 |
|Mammary Gland                                                                                                                    |
|     Fibroma, Fibroadenoma, Carcinoma, or Adenoma                                                                                |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #        |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  7/50 (14%)   2/50 (4%)    3/50 (6%)    1/50 (2%)  | 32/50 (64%)  25/50 (50%)  17/50 (34%)  25/50 (50%) |
|ADJUSTED (b)           |  26.0%        10.9%        20.0%         7.7%      |  86.3%        60.6%        50.0%        59.2%      |
|TERMINAL (d)           |  3/21 (14%)   1/15 (7%)    3/15 (20%)   1/13 (8%)  | 25/30 (83%)  22/38 (58%)  15/32 (47%)  21/38 (55%) |
|FIRST INCIDENCE (DAYS) |   534          693          729 (T)      729 (T)   |   594          435          729          330       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.075N     P=0.162N     P=0.295N     P=0.088N   |  P=0.021N*    P=0.007N**   P<0.001N**   P=0.009N** |
|INCIDENTAL TUMOR       |  P=0.030N*    P=0.068N     P=0.143N     P=0.022N*  |  P=0.034N*    P=0.019N*    P<0.001N**   P=0.039N*  |
|LOGISTIC REGRESSION    |  P=0.030N*    P=0.084N     P=0.142N     P=0.030N*  |  P=0.043N*    P=0.021N*    P<0.001N**   P=0.073N   |
|COCHRAN-ARMITAGE       |  P=0.030N*                                         |  P=0.103N                                          |
|FISHER EXACT           |               P=0.080N     P=0.159N     P=0.030N*  |               P=0.113N     P=0.002N**   P=0.113N   |
|=================================================================================================================================|
         DATE: 04/04/96                     EXPERIMENT: 05182 TEST: 03                                                 PAGE  14
                             STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- PHENOLPHTHALEIN
                                                 TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   0 PPM        12000        25000        50000     |   0 PPM        12000        25000        50000     |
|                       |                PPM          PPM          PPM       |                PPM          PPM          PPM       |
|=================================================================================================================================|
|                                                                                                                                 |
|Oral Cavity (Oral Mucosa, Tongue, Pharynx, Tooth, Gingiva)                                                                       |
|     Papilloma Squamous or Papilloma                                                                                             |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #        |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  1/50 (2%)    0/50 (0%)    0/50 (0%)    0/50 (0%)  |  0/50 (0%)    2/50 (4%)    0/50 (0%)    0/50 (0%)  |
|ADJUSTED (b)           |   2.9%         0.0%         0.0%         0.0%      |   0.0%         5.1%         0.0%         0.0%      |
|TERMINAL (d)           |  0/21 (0%)    0/15 (0%)    0/15 (0%)    0/13 (0%)  |  0/30 (0%)    1/38 (3%)    0/32 (0%)    0/38 (0%)  |
|FIRST INCIDENCE (DAYS) |   601          ---          ---          ---       |   ---          717          ---          ---       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.289N     P=0.489N     P=0.459N     P=0.473N   |  P=0.366N     P=0.292        (e)          (e)      |
|INCIDENTAL TUMOR       |  P=0.325N     P=0.425N     P=0.519N     P=0.500N   |  P=0.461N     P=0.240        (e)          (e)      |
|LOGISTIC REGRESSION    |  P=0.330N     P=0.522N     P=0.519N     P=0.539N   |  P=0.384N     P=0.271        (e)          (e)      |
|COCHRAN-ARMITAGE       |  P=0.309N                                          |  P=0.394N                                          |
|FISHER EXACT           |               P=0.500N     P=0.500N     P=0.500N   |               P=0.247        (e)          (e)      |
|=================================================================================================================================|
|                                                                                                                                 |
|Oral Cavity (Oral Mucosa, Tongue, Pharynx, Tooth, Gingiva)                                                                       |
|     Squamous Cell Carcinoma                                                                                                     |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #        |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  0/50 (0%)    0/50 (0%)    1/50 (2%)    0/50 (0%)  |  2/50 (4%)    1/50 (2%)    0/50 (0%)    0/50 (0%)  |
|ADJUSTED (b)           |   0.0%         0.0%         3.2%         0.0%      |   5.1%         2.6%         0.0%         0.0%      |
|TERMINAL (d)           |  0/21 (0%)    0/15 (0%)    0/15 (0%)    0/13 (0%)  |  0/30 (0%)    1/38 (3%)    0/32 (0%)    0/38 (0%)  |
|FIRST INCIDENCE (DAYS) |   ---          ---          664          ---       |   370          735 (T)      ---          ---       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.704        (e)        P=0.520        (e)      |  P=0.093N     P=0.453N     P=0.230N     P=0.222N   |
|INCIDENTAL TUMOR       |  P=0.711N       (e)        P=0.682        (e)      |  P=0.120N     P=0.661N     P=0.336N     P=0.362N   |
|LOGISTIC REGRESSION    |  P=0.695        (e)        P=0.505        (e)      |  P=0.094N     P=0.657N     P=0.343N     P=0.216N   |
|COCHRAN-ARMITAGE       |  P=0.691                                           |  P=0.101N                                          |
|FISHER EXACT           |                 (e)        P=0.500        (e)      |               P=0.500N     P=0.247N     P=0.247N   |
|=================================================================================================================================|
         DATE: 04/04/96                     EXPERIMENT: 05182 TEST: 03                                                 PAGE  15
                             STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- PHENOLPHTHALEIN
                                                 TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   0 PPM        12000        25000        50000     |   0 PPM        12000        25000        50000     |
|                       |                PPM          PPM          PPM       |                PPM          PPM          PPM       |
|=================================================================================================================================|
|                                                                                                                                 |
|Oral Cavity (Oral Mucosa, Tongue, Pharynx, Tooth, Gingiva)                                                                       |
|     Squamous Cell Carcinoma, Papilloma Squamous, or Papilloma                                                                   |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #        |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  1/50 (2%)    0/50 (0%)    1/50 (2%)    0/50 (0%)  |  2/50 (4%)    3/50 (6%)    0/50 (0%)    0/50 (0%)  |
|ADJUSTED (b)           |   2.9%         0.0%         3.2%         0.0%      |   5.1%         7.6%         0.0%         0.0%      |
|TERMINAL (d)           |  0/21 (0%)    0/15 (0%)    0/15 (0%)    0/13 (0%)  |  0/30 (0%)    2/38 (5%)    0/32 (0%)    0/38 (0%)  |
|FIRST INCIDENCE (DAYS) |   601          ---          664          ---       |   370          717          ---          ---       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.384N     P=0.489N     P=0.726N     P=0.473N   |  P=0.061N     P=0.577      P=0.230N     P=0.222N   |
|INCIDENTAL TUMOR       |  P=0.337N     P=0.425N     P=0.677N     P=0.500N   |  P=0.093N     P=0.377      P=0.336N     P=0.362N   |
|LOGISTIC REGRESSION    |  P=0.422N     P=0.522N     P=0.757      P=0.539N   |  P=0.070N     P=0.408      P=0.343N     P=0.216N   |
|COCHRAN-ARMITAGE       |  P=0.409N                                          |  P=0.071N                                          |
|FISHER EXACT           |               P=0.500N     P=0.753N     P=0.500N   |               P=0.500      P=0.247N     P=0.247N   |
|=================================================================================================================================|
|                                                                                                                                 |
|Oral Mucosa                                                                                                                      |
|     Squamous Cell Papilloma                                                                                                     |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #        |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  1/50 (2%)    0/50 (0%)    0/50 (0%)    0/50 (0%)  |  0/50 (0%)    2/50 (4%)    0/50 (0%)    0/50 (0%)  |
|ADJUSTED (b)           |   2.9%         0.0%         0.0%         0.0%      |   0.0%         5.1%         0.0%         0.0%      |
|TERMINAL (d)           |  0/21 (0%)    0/15 (0%)    0/15 (0%)    0/13 (0%)  |  0/30 (0%)    1/38 (3%)    0/32 (0%)    0/38 (0%)  |
|FIRST INCIDENCE (DAYS) |   601          ---          ---          ---       |   ---          717          ---          ---       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.289N     P=0.489N     P=0.459N     P=0.473N   |  P=0.366N     P=0.292        (e)          (e)      |
|INCIDENTAL TUMOR       |  P=0.325N     P=0.425N     P=0.519N     P=0.500N   |  P=0.461N     P=0.240        (e)          (e)      |
|LOGISTIC REGRESSION    |  P=0.330N     P=0.522N     P=0.519N     P=0.539N   |  P=0.384N     P=0.271        (e)          (e)      |
|COCHRAN-ARMITAGE       |  P=0.309N                                          |  P=0.394N                                          |
|FISHER EXACT           |               P=0.500N     P=0.500N     P=0.500N   |               P=0.247        (e)          (e)      |
|=================================================================================================================================|
         DATE: 04/04/96                     EXPERIMENT: 05182 TEST: 03                                                 PAGE  16
                             STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- PHENOLPHTHALEIN
                                                 TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   0 PPM        12000        25000        50000     |   0 PPM        12000        25000        50000     |
|                       |                PPM          PPM          PPM       |                PPM          PPM          PPM       |
|=================================================================================================================================|
|                                                                                                                                 |
|Ovary                                                                                                                            |
|     Granulosa Cell Tumor Benign                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |                                                    |  0/50 (0%)    2/50 (4%)    0/50 (0%)    0/50 (0%)  |
|ADJUSTED (b)           |                                                    |   0.0%         5.3%         0.0%         0.0%      |
|TERMINAL (d)           |                                                    |  0/30 (0%)    2/38 (5%)    0/32 (0%)    0/38 (0%)  |
|FIRST INCIDENCE (DAYS) |                                                    |   ---          735 (T)      ---          ---       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |                                                    |  P=0.363N     P=0.292        (e)          (e)      |
|INCIDENTAL TUMOR       |                                                    |  P=0.363N     P=0.292        (e)          (e)      |
|LOGISTIC REGRESSION    |                                                    |  P=0.363N     P=0.292        (e)          (e)      |
|COCHRAN-ARMITAGE       |                                                    |  P=0.394N                                          |
|FISHER EXACT           |                                                    |               P=0.247        (e)          (e)      |
|=================================================================================================================================|
|                                                                                                                                 |
|Ovary                                                                                                                            |
|     Granulosa Cell Tumor: Benign, Malignant, NOS                                                                                |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |                                                    |  0/50 (0%)    2/50 (4%)    1/50 (2%)    0/50 (0%)  |
|ADJUSTED (b)           |                                                    |   0.0%         5.3%         3.1%         0.0%      |
|TERMINAL (d)           |                                                    |  0/30 (0%)    2/38 (5%)    1/32 (3%)    0/38 (0%)  |
|FIRST INCIDENCE (DAYS) |                                                    |   ---          735 (T)      735 (T)      ---       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |                                                    |  P=0.413N     P=0.292      P=0.513        (e)      |
|INCIDENTAL TUMOR       |                                                    |  P=0.413N     P=0.292      P=0.513        (e)      |
|LOGISTIC REGRESSION    |                                                    |  P=0.413N     P=0.292      P=0.513        (e)      |
|COCHRAN-ARMITAGE       |                                                    |  P=0.453N                                          |
|FISHER EXACT           |                                                    |               P=0.247      P=0.500        (e)      |
|=================================================================================================================================|
         DATE: 04/04/96                     EXPERIMENT: 05182 TEST: 03                                                 PAGE  17
                             STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- PHENOLPHTHALEIN
                                                 TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   0 PPM        12000        25000        50000     |   0 PPM        12000        25000        50000     |
|                       |                PPM          PPM          PPM       |                PPM          PPM          PPM       |
|=================================================================================================================================|
|                                                                                                                                 |
|Pancreas                                                                                                                         |
|     Adenoma                                                                                                                     |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  1/50 (2%)    0/50 (0%)    2/50 (4%)    1/47 (2%)  |  0/49 (0%)    0/49 (0%)    0/49 (0%)    1/46 (2%)  |
|ADJUSTED (b)           |   4.8%         0.0%        12.5%         7.7%      |   0.0%         0.0%         0.0%         2.6%      |
|TERMINAL (d)           |  1/21 (5%)    0/15 (0%)    1/15 (7%)    1/13 (8%)  |  0/30 (0%)    0/38 (0%)    0/32 (0%)    1/38 (3%)  |
|FIRST INCIDENCE (DAYS) |   729 (T)      ---          727          729 (T)   |   ---          ---          ---          735 (T)   |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.364      P=0.567N     P=0.386      P=0.652    |  P=0.217        (e)          (e)        P=0.547    |
|INCIDENTAL TUMOR       |  P=0.453      P=0.567N     P=0.523      P=0.652    |  P=0.217        (e)          (e)        P=0.547    |
|LOGISTIC REGRESSION    |  P=0.365      P=0.567N     P=0.388      P=0.652    |  P=0.217        (e)          (e)        P=0.547    |
|COCHRAN-ARMITAGE       |  P=0.476                                           |  P=0.188                                           |
|FISHER EXACT           |               P=0.500N     P=0.500      P=0.737    |                 (e)          (e)        P=0.484    |
|=================================================================================================================================|
|                                                                                                                                 |
|Pituitary Gland: Pars Distalis or Unspecified Site                                                                               |
|     Adenoma                                                                                                                     |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            | 13/50 (26%)  11/50 (22%)  16/50 (32%)  11/50 (22%) | 35/50 (70%)  32/49 (65%)  29/50 (58%)  25/47 (53%) |
|ADJUSTED (b)           |  42.9%        50.8%        67.3%        51.3%      |  89.5%        77.7%        75.6%        63.9%      |
|TERMINAL (d)           |  6/21 (29%)   6/15 (40%)   8/15 (53%)   5/13 (38%) | 26/30 (87%)  28/37 (76%)  23/32 (72%)  23/37 (62%) |
|FIRST INCIDENCE (DAYS) |   407          610          623          542       |   370          571          391          506       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.362      P=0.555      P=0.169      P=0.528    |  P=0.002N**   P=0.040N*    P=0.078N     P=0.002N** |
|INCIDENTAL TUMOR       |  P=0.438N     P=0.416N     P=0.440      P=0.460N   |  P=0.011N*    P=0.114N     P=0.105N     P=0.022N*  |
|LOGISTIC REGRESSION    |  P=0.390N     P=0.391N     P=0.388      P=0.367N   |  P=0.032N*    P=0.154N     P=0.090N     P=0.034N*  |
|COCHRAN-ARMITAGE       |  P=0.449N                                          |  P=0.044N*                                         |
|FISHER EXACT           |               P=0.408N     P=0.330      P=0.408N   |               P=0.388N     P=0.149N     P=0.067N   |
|=================================================================================================================================|
         DATE: 04/04/96                     EXPERIMENT: 05182 TEST: 03                                                 PAGE  18
                             STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- PHENOLPHTHALEIN
                                                 TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   0 PPM        12000        25000        50000     |   0 PPM        12000        25000        50000     |
|                       |                PPM          PPM          PPM       |                PPM          PPM          PPM       |
|=================================================================================================================================|
|                                                                                                                                 |
|Pituitary Gland: Pars Distalis or Unspecified Site                                                                               |
|     Carcinoma or Adenoma                                                                                                        |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            | 13/50 (26%)  11/50 (22%)  16/50 (32%)  11/50 (22%) | 36/50 (72%)  32/49 (65%)  29/50 (58%)  25/47 (53%) |
|ADJUSTED (b)           |  42.9%        50.8%        67.3%        51.3%      |  89.8%        77.7%        75.6%        63.9%      |
|TERMINAL (d)           |  6/21 (29%)   6/15 (40%)   8/15 (53%)   5/13 (38%) | 26/30 (87%)  28/37 (76%)  23/32 (72%)  23/37 (62%) |
|FIRST INCIDENCE (DAYS) |   407          610          623          542       |   370          571          391          506       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.362      P=0.555      P=0.169      P=0.528    |  P=0.001N**   P=0.027N*    P=0.055N     P<0.001N** |
|INCIDENTAL TUMOR       |  P=0.438N     P=0.416N     P=0.440      P=0.460N   |  P=0.008N**   P=0.079N     P=0.070N     P=0.018N*  |
|LOGISTIC REGRESSION    |  P=0.390N     P=0.391N     P=0.388      P=0.367N   |  P=0.021N*    P=0.102N     P=0.057N     P=0.020N*  |
|COCHRAN-ARMITAGE       |  P=0.449N                                          |  P=0.030N*                                         |
|FISHER EXACT           |               P=0.408N     P=0.330      P=0.408N   |               P=0.308N     P=0.104N     P=0.044N*  |
|=================================================================================================================================|
|                                                                                                                                 |
|Prostate                                                                                                                         |
|     Adenoma                                                                                                                     |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  2/50 (4%)    0/50 (0%)    0/50 (0%)    0/50 (0%)  |                                                    |
|ADJUSTED (b)           |   9.5%         0.0%         0.0%         0.0%      |                                                    |
|TERMINAL (d)           |  2/21 (10%)   0/15 (0%)    0/15 (0%)    0/13 (0%)  |                                                    |
|FIRST INCIDENCE (DAYS) |   729 (T)      ---          ---          ---       |                                                    |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.163N     P=0.314N     P=0.314N     P=0.348N   |                                                    |
|INCIDENTAL TUMOR       |  P=0.163N     P=0.314N     P=0.314N     P=0.348N   |                                                    |
|LOGISTIC REGRESSION    |  P=0.163N     P=0.314N     P=0.314N     P=0.348N   |                                                    |
|COCHRAN-ARMITAGE       |  P=0.118N                                          |                                                    |
|FISHER EXACT           |               P=0.247N     P=0.247N     P=0.247N   |                                                    |
|=================================================================================================================================|
         DATE: 04/04/96                     EXPERIMENT: 05182 TEST: 03                                                 PAGE  19
                             STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- PHENOLPHTHALEIN
                                                 TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   0 PPM        12000        25000        50000     |   0 PPM        12000        25000        50000     |
|                       |                PPM          PPM          PPM       |                PPM          PPM          PPM       |
|=================================================================================================================================|
|                                                                                                                                 |
|Skin                                                                                                                             |
|     Basal Cell Adenoma                                                                                                          |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #        |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  2/50 (4%)    0/50 (0%)    1/50 (2%)    0/50 (0%)  |  0/50 (0%)    0/50 (0%)    0/50 (0%)    1/50 (2%)  |
|ADJUSTED (b)           |   8.3%         0.0%         6.7%         0.0%      |   0.0%         0.0%         0.0%         2.6%      |
|TERMINAL (d)           |  1/21 (5%)    0/15 (0%)    1/15 (7%)    0/13 (0%)  |  0/30 (0%)    0/38 (0%)    0/32 (0%)    1/38 (3%)  |
|FIRST INCIDENCE (DAYS) |   685          ---          729 (T)      ---       |   ---          ---          ---          735 (T)   |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.254N     P=0.290N     P=0.591N     P=0.311N   |  P=0.217        (e)          (e)        P=0.547    |
|INCIDENTAL TUMOR       |  P=0.188N     P=0.219N     P=0.477N     P=0.179N   |  P=0.217        (e)          (e)        P=0.547    |
|LOGISTIC REGRESSION    |  P=0.205N     P=0.251N     P=0.513N     P=0.244N   |  P=0.217        (e)          (e)        P=0.547    |
|COCHRAN-ARMITAGE       |  P=0.192N                                          |  P=0.197                                           |
|FISHER EXACT           |               P=0.247N     P=0.500N     P=0.247N   |                 (e)          (e)        P=0.500    |
|=================================================================================================================================|
|                                                                                                                                 |
|Skin                                                                                                                             |
|     Basal or Sq. Cell Carcinoma, Carcinoma, Basosq. Tumor (M or B), Basal                                                       |
|     Cell Adenoma, Adenoma, Papilloma, Sq Papilloma, Keratoacanthoma, Trichoepithelioma                                          |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #        |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  5/50 (10%)   3/50 (6%)    3/50 (6%)    1/50 (2%)  |  1/50 (2%)    0/50 (0%)    0/50 (0%)    1/50 (2%)  |
|ADJUSTED (b)           |  22.0%        15.2%        15.4%         2.1%      |   3.3%         0.0%         0.0%         2.6%      |
|TERMINAL (d)           |  4/21 (19%)   1/15 (7%)    2/15 (13%)   0/13 (0%)  |  1/30 (3%)    0/38 (0%)    0/32 (0%)    1/38 (3%)  |
|FIRST INCIDENCE (DAYS) |   685          693          622          528       |   735 (T)      ---          ---          735 (T)   |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.141N     P=0.512N     P=0.484N     P=0.190N   |  P=0.623      P=0.453N     P=0.487N     P=0.708N   |
|INCIDENTAL TUMOR       |  P=0.094N     P=0.368N     P=0.442N     P=0.159N   |  P=0.623      P=0.453N     P=0.487N     P=0.708N   |
|LOGISTIC REGRESSION    |  P=0.073N     P=0.416N     P=0.353N     P=0.095N   |  P=0.623      P=0.453N     P=0.487N     P=0.708N   |
|COCHRAN-ARMITAGE       |  P=0.080N                                          |  P=0.591                                           |
|FISHER EXACT           |               P=0.357N     P=0.357N     P=0.102N   |               P=0.500N     P=0.500N     P=0.753N   |
|=================================================================================================================================|
         DATE: 04/04/96                     EXPERIMENT: 05182 TEST: 03                                                 PAGE  20
                             STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- PHENOLPHTHALEIN
                                                 TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   0 PPM        12000        25000        50000     |   0 PPM        12000        25000        50000     |
|                       |                PPM          PPM          PPM       |                PPM          PPM          PPM       |
|=================================================================================================================================|
|                                                                                                                                 |
|Skin                                                                                                                             |
|     Fibroma                                                                                                                     |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #        |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  3/50 (6%)    2/50 (4%)    1/50 (2%)    2/50 (4%)  |  1/50 (2%)    2/50 (4%)    0/50 (0%)    1/50 (2%)  |
|ADJUSTED (b)           |  10.8%         4.8%         6.7%         8.0%      |   2.5%         5.3%         0.0%         2.6%      |
|TERMINAL (d)           |  1/21 (5%)    0/15 (0%)    1/15 (7%)    0/13 (0%)  |  0/30 (0%)    2/38 (5%)    0/32 (0%)    1/38 (3%)  |
|FIRST INCIDENCE (DAYS) |   534          561          729 (T)      673       |   648          735 (T)      ---          735 (T)   |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.448N     P=0.526N     P=0.385N     P=0.568N   |  P=0.460N     P=0.571      P=0.495N     P=0.732N   |
|INCIDENTAL TUMOR       |  P=0.356N     P=0.445N     P=0.326N     P=0.332N   |  P=0.521N     P=0.529      P=0.500N     P=0.672    |
|LOGISTIC REGRESSION    |  P=0.407N     P=0.518N     P=0.292N     P=0.488N   |  P=0.493N     P=0.517      P=0.527N     P=0.761N   |
|COCHRAN-ARMITAGE       |  P=0.404N                                          |  P=0.495N                                          |
|FISHER EXACT           |               P=0.500N     P=0.309N     P=0.500N   |               P=0.500      P=0.500N     P=0.753N   |
|=================================================================================================================================|
|                                                                                                                                 |
|Skin                                                                                                                             |
|     Keratoacanthoma                                                                                                             |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #        |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  4/50 (8%)    2/50 (4%)    3/50 (6%)    1/50 (2%)  |  0/50 (0%)    0/50 (0%)    0/50 (0%)    0/50 (0%)  |
|ADJUSTED (b)           |  17.5%        10.9%        15.4%         2.1%      |   0.0%         0.0%         0.0%         0.0%      |
|TERMINAL (d)           |  3/21 (14%)   1/15 (7%)    2/15 (13%)   0/13 (0%)  |  0/30 (0%)    0/38 (0%)    0/32 (0%)    0/38 (0%)  |
|FIRST INCIDENCE (DAYS) |   685          693          622          528       |   ---          ---          ---          ---       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.245N     P=0.468N     P=0.614N     P=0.276N   |    (e)          (e)          (e)          (e)      |
|INCIDENTAL TUMOR       |  P=0.207N     P=0.363N     P=0.573N     P=0.236N   |    (e)          (e)          (e)          (e)      |
|LOGISTIC REGRESSION    |  P=0.153N     P=0.391N     P=0.493N     P=0.168N   |    (e)          (e)          (e)          (e)      |
|COCHRAN-ARMITAGE       |  P=0.164N                                          |    (e)                                             |
|FISHER EXACT           |               P=0.339N     P=0.500N     P=0.181N   |                 (e)          (e)          (e)      |
|=================================================================================================================================|
         DATE: 04/04/96                     EXPERIMENT: 05182 TEST: 03                                                 PAGE  21
                             STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- PHENOLPHTHALEIN
                                                 TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   0 PPM        12000        25000        50000     |   0 PPM        12000        25000        50000     |
|                       |                PPM          PPM          PPM       |                PPM          PPM          PPM       |
|=================================================================================================================================|
|                                                                                                                                 |
|Skin                                                                                                                             |
|     Schwannoma Malignant                                                                                                        |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #        |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  2/50 (4%)    0/50 (0%)    0/50 (0%)    3/50 (6%)  |  0/50 (0%)    0/50 (0%)    0/50 (0%)    0/50 (0%)  |
|ADJUSTED (b)           |   7.6%         0.0%         0.0%        11.9%      |   0.0%         0.0%         0.0%         0.0%      |
|TERMINAL (d)           |  1/21 (5%)    0/15 (0%)    0/15 (0%)    1/13 (8%)  |  0/30 (0%)    0/38 (0%)    0/32 (0%)    0/38 (0%)  |
|FIRST INCIDENCE (DAYS) |   608          ---          ---          570       |   ---          ---          ---          ---       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.220      P=0.266N     P=0.251N     P=0.457    |    (e)          (e)          (e)          (e)      |
|INCIDENTAL TUMOR       |  P=0.171      P=0.232N     P=0.288N     P=0.413    |    (e)          (e)          (e)          (e)      |
|LOGISTIC REGRESSION    |  P=0.234      P=0.235N     P=0.231N     P=0.493    |    (e)          (e)          (e)          (e)      |
|COCHRAN-ARMITAGE       |  P=0.241                                           |    (e)                                             |
|FISHER EXACT           |               P=0.247N     P=0.247N     P=0.500    |                 (e)          (e)          (e)      |
|=================================================================================================================================|
|                                                                                                                                 |
|Skin                                                                                                                             |
|     Squamous Cell Papilloma, Papilloma, Squamous Cell Carcinoma or Keratoacanthoma                                              |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #        |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  4/50 (8%)    3/50 (6%)    3/50 (6%)    1/50 (2%)  |  1/50 (2%)    0/50 (0%)    0/50 (0%)    0/50 (0%)  |
|ADJUSTED (b)           |  17.5%        15.2%        15.4%         2.1%      |   3.3%         0.0%         0.0%         0.0%      |
|TERMINAL (d)           |  3/21 (14%)   1/15 (7%)    2/15 (13%)   0/13 (0%)  |  1/30 (3%)    0/38 (0%)    0/32 (0%)    0/38 (0%)  |
|FIRST INCIDENCE (DAYS) |   685          693          622          528       |   735 (T)      ---          ---          ---       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.212N     P=0.640N     P=0.614N     P=0.276N   |  P=0.290N     P=0.453N     P=0.487N     P=0.453N   |
|INCIDENTAL TUMOR       |  P=0.148N     P=0.492N     P=0.573N     P=0.236N   |  P=0.290N     P=0.453N     P=0.487N     P=0.453N   |
|LOGISTIC REGRESSION    |  P=0.125N     P=0.556N     P=0.493N     P=0.168N   |  P=0.290N     P=0.453N     P=0.487N     P=0.453N   |
|COCHRAN-ARMITAGE       |  P=0.136N                                          |  P=0.309N                                          |
|FISHER EXACT           |               P=0.500N     P=0.500N     P=0.181N   |               P=0.500N     P=0.500N     P=0.500N   |
|=================================================================================================================================|
         DATE: 04/04/96                     EXPERIMENT: 05182 TEST: 03                                                 PAGE  22
                             STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- PHENOLPHTHALEIN
                                                 TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   0 PPM        12000        25000        50000     |   0 PPM        12000        25000        50000     |
|                       |                PPM          PPM          PPM       |                PPM          PPM          PPM       |
|=================================================================================================================================|
|                                                                                                                                 |
|Skin                                                                                                                             |
|     Squamous Cell Papilloma, Papilloma, or Keratoacanthoma                                                                      |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #        |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  4/50 (8%)    2/50 (4%)    3/50 (6%)    1/50 (2%)  |  1/50 (2%)    0/50 (0%)    0/50 (0%)    0/50 (0%)  |
|ADJUSTED (b)           |  17.5%        10.9%        15.4%         2.1%      |   3.3%         0.0%         0.0%         0.0%      |
|TERMINAL (d)           |  3/21 (14%)   1/15 (7%)    2/15 (13%)   0/13 (0%)  |  1/30 (3%)    0/38 (0%)    0/32 (0%)    0/38 (0%)  |
|FIRST INCIDENCE (DAYS) |   685          693          622          528       |   735 (T)      ---          ---          ---       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.245N     P=0.468N     P=0.614N     P=0.276N   |  P=0.290N     P=0.453N     P=0.487N     P=0.453N   |
|INCIDENTAL TUMOR       |  P=0.207N     P=0.363N     P=0.573N     P=0.236N   |  P=0.290N     P=0.453N     P=0.487N     P=0.453N   |
|LOGISTIC REGRESSION    |  P=0.153N     P=0.391N     P=0.493N     P=0.168N   |  P=0.290N     P=0.453N     P=0.487N     P=0.453N   |
|COCHRAN-ARMITAGE       |  P=0.164N                                          |  P=0.309N                                          |
|FISHER EXACT           |               P=0.339N     P=0.500N     P=0.181N   |               P=0.500N     P=0.500N     P=0.500N   |
|=================================================================================================================================|
|                                                                                                                                 |
|Testes                                                                                                                           |
|     Adenoma                                                                                                                     |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            | 46/50 (92%)  46/50 (92%)  49/50 (98%)  49/50 (98%) |                                                    |
|ADJUSTED (b)           | 100.0%        97.8%       100.0%       100.0%      |                                                    |
|TERMINAL (d)           | 21/21 (100%) 14/15 (93%)  15/15 (100%) 13/13 (100%)|                                                    |
|FIRST INCIDENCE (DAYS) |   486          458          372          485       |                                                    |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.112      P=0.233      P=0.180      P=0.103    |                                                    |
|INCIDENTAL TUMOR       |  P=0.270      P=0.403N     P=0.621      P=0.448    |                                                    |
|LOGISTIC REGRESSION    |  P=0.223      P=0.365N     P=0.225      P=0.680    |                                                    |
|COCHRAN-ARMITAGE       |  P=0.076                                           |                                                    |
|FISHER EXACT           |               P=0.643N     P=0.181      P=0.181    |                                                    |
|=================================================================================================================================|
         DATE: 04/04/96                     EXPERIMENT: 05182 TEST: 03                                                 PAGE  23
                             STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- PHENOLPHTHALEIN
                                                 TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   0 PPM        12000        25000        50000     |   0 PPM        12000        25000        50000     |
|                       |                PPM          PPM          PPM       |                PPM          PPM          PPM       |
|=================================================================================================================================|
|                                                                                                                                 |
|Thyroid Gland: C-Cell                                                                                                            |
|     Adenoma                                                                                                                     |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  9/50 (18%)   2/50 (4%)    3/49 (6%)    4/49 (8%)  |  7/50 (14%)   5/50 (10%)   7/50 (14%)   7/48 (15%) |
|ADJUSTED (b)           |  35.3%         8.2%        13.7%        12.3%      |  21.2%        12.6%        20.5%        18.4%      |
|TERMINAL (d)           |  6/21 (29%)   0/15 (0%)    1/15 (7%)    0/13 (0%)  |  5/30 (17%)   4/38 (11%)   5/32 (16%)   7/38 (18%) |
|FIRST INCIDENCE (DAYS) |   571          531          623          570       |   659          679          717          735 (T)   |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.216N     P=0.061N     P=0.111N     P=0.214N   |  P=0.524N     P=0.241N     P=0.557N     P=0.440N   |
|INCIDENTAL TUMOR       |  P=0.145N     P=0.033N*    P=0.076N     P=0.116N   |  P=0.416      P=0.297N     P=0.578N     P=0.610N   |
|LOGISTIC REGRESSION    |  P=0.137N     P=0.026N*    P=0.055N     P=0.108N   |  P=0.493      P=0.293N     P=0.549N     P=0.561N   |
|COCHRAN-ARMITAGE       |  P=0.152N                                          |  P=0.435                                           |
|FISHER EXACT           |               P=0.026N*    P=0.065N     P=0.125N   |               P=0.380N     P=0.613N     P=0.581    |
|=================================================================================================================================|
|                                                                                                                                 |
|Thyroid Gland: C-Cell                                                                                                            |
|     Carcinoma                                                                                                                   |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  0/50 (0%)    0/50 (0%)    1/49 (2%)    2/49 (4%)  |  1/50 (2%)    3/50 (6%)    0/50 (0%)    2/48 (4%)  |
|ADJUSTED (b)           |   0.0%         0.0%         6.7%        11.3%      |   3.3%         7.4%         0.0%         5.3%      |
|TERMINAL (d)           |  0/21 (0%)    0/15 (0%)    1/15 (7%)    0/13 (0%)  |  1/30 (3%)    2/38 (5%)    0/32 (0%)    2/38 (5%)  |
|FIRST INCIDENCE (DAYS) |   ---          ---          729 (T)      700       |   735 (T)      674          ---          735 (T)   |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.044 *      (e)        P=0.433      P=0.168    |  P=0.606N     P=0.390      P=0.487N     P=0.583    |
|INCIDENTAL TUMOR       |  P=0.103        (e)        P=0.433      P=0.455    |  P=0.552      P=0.350      P=0.487N     P=0.583    |
|LOGISTIC REGRESSION    |  P=0.057        (e)        P=0.433      P=0.219    |  P=0.568      P=0.346      P=0.487N     P=0.583    |
|COCHRAN-ARMITAGE       |  P=0.067                                           |  P=0.547                                           |
|FISHER EXACT           |                 (e)        P=0.495      P=0.242    |               P=0.309      P=0.500N     P=0.485    |
|=================================================================================================================================|
         DATE: 04/04/96                     EXPERIMENT: 05182 TEST: 03                                                 PAGE  24
                             STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- PHENOLPHTHALEIN
                                                 TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   0 PPM        12000        25000        50000     |   0 PPM        12000        25000        50000     |
|                       |                PPM          PPM          PPM       |                PPM          PPM          PPM       |
|=================================================================================================================================|
|                                                                                                                                 |
|Thyroid Gland: C-Cell                                                                                                            |
|     Carcinoma or Adenoma                                                                                                        |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  9/50 (18%)   2/50 (4%)    4/49 (8%)    6/49 (12%) |  8/50 (16%)   8/50 (16%)   7/50 (14%)   9/48 (19%) |
|ADJUSTED (b)           |  35.3%         8.2%        19.9%        22.2%      |  24.3%        19.6%        20.5%        23.7%      |
|TERMINAL (d)           |  6/21 (29%)   0/15 (0%)    2/15 (13%)   0/13 (0%)  |  6/30 (20%)   6/38 (16%)   5/32 (16%)   9/38 (24%) |
|FIRST INCIDENCE (DAYS) |   571          531          623          570       |   659          674          717          735 (T)   |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.532N     P=0.061N     P=0.200N     P=0.459N   |  P=0.520N     P=0.419N     P=0.442N     P=0.514N   |
|INCIDENTAL TUMOR       |  P=0.369N     P=0.033N*    P=0.152N     P=0.212N   |  P=0.394      P=0.504N     P=0.460N     P=0.548    |
|LOGISTIC REGRESSION    |  P=0.386N     P=0.026N*    P=0.106N     P=0.271N   |  P=0.471      P=0.503N     P=0.429N     P=0.574    |
|COCHRAN-ARMITAGE       |  P=0.417N                                          |  P=0.410                                           |
|FISHER EXACT           |               P=0.026N*    P=0.125N     P=0.303N   |               P=0.607N     P=0.500N     P=0.463    |
|=================================================================================================================================|
|                                                                                                                                 |
|Thyroid Gland: Follicular Cell                                                                                                   |
|     Adenoma                                                                                                                     |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  0/50 (0%)    1/50 (2%)    2/49 (4%)    3/49 (6%)  |  0/50 (0%)    0/50 (0%)    0/50 (0%)    0/48 (0%)  |
|ADJUSTED (b)           |   0.0%         3.6%        13.3%        16.1%      |   0.0%         0.0%         0.0%         0.0%      |
|TERMINAL (d)           |  0/21 (0%)    0/15 (0%)    2/15 (13%)   1/13 (8%)  |  0/30 (0%)    0/38 (0%)    0/32 (0%)    0/38 (0%)  |
|FIRST INCIDENCE (DAYS) |   ---          646          729 (T)      685       |   ---          ---          ---          ---       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.039 *    P=0.493      P=0.166      P=0.076    |    (e)          (e)          (e)          (e)      |
|INCIDENTAL TUMOR       |  P=0.080      P=0.597      P=0.166      P=0.193    |    (e)          (e)          (e)          (e)      |
|LOGISTIC REGRESSION    |  P=0.057      P=0.500      P=0.166      P=0.110    |    (e)          (e)          (e)          (e)      |
|COCHRAN-ARMITAGE       |  P=0.059                                           |    (e)                                             |
|FISHER EXACT           |               P=0.500      P=0.242      P=0.117    |                 (e)          (e)          (e)      |
|=================================================================================================================================|
         DATE: 04/04/96                     EXPERIMENT: 05182 TEST: 03                                                 PAGE  25
                             STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- PHENOLPHTHALEIN
                                                 TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   0 PPM        12000        25000        50000     |   0 PPM        12000        25000        50000     |
|                       |                PPM          PPM          PPM       |                PPM          PPM          PPM       |
|=================================================================================================================================|
|                                                                                                                                 |
|Thyroid Gland: Follicular Cell                                                                                                   |
|     Carcinoma or Adenoma                                                                                                        |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  1/50 (2%)    1/50 (2%)    2/49 (4%)    3/49 (6%)  |  0/50 (0%)    0/50 (0%)    0/50 (0%)    0/48 (0%)  |
|ADJUSTED (b)           |   2.4%         3.6%        13.3%        16.1%      |   0.0%         0.0%         0.0%         0.0%      |
|TERMINAL (d)           |  0/21 (0%)    0/15 (0%)    2/15 (13%)   1/13 (8%)  |  0/30 (0%)    0/38 (0%)    0/32 (0%)    0/38 (0%)  |
|FIRST INCIDENCE (DAYS) |   529          646          729 (T)      685       |   ---          ---          ---          ---       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.121      P=0.752N     P=0.430      P=0.241    |    (e)          (e)          (e)          (e)      |
|INCIDENTAL TUMOR       |  P=0.183      P=0.743N     P=0.369      P=0.372    |    (e)          (e)          (e)          (e)      |
|LOGISTIC REGRESSION    |  P=0.168      P=0.735      P=0.500      P=0.305    |    (e)          (e)          (e)          (e)      |
|COCHRAN-ARMITAGE       |  P=0.158                                           |    (e)                                             |
|FISHER EXACT           |               P=0.753N     P=0.492      P=0.301    |                 (e)          (e)          (e)      |
|=================================================================================================================================|
|                                                                                                                                 |
|Tongue                                                                                                                           |
|     Squamous Cell Carcinoma                                                                                                     |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #        |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  0/50 (0%)    0/50 (0%)    0/50 (0%)    0/50 (0%)  |  2/50 (4%)    1/50 (2%)    0/50 (0%)    0/50 (0%)  |
|ADJUSTED (b)           |   0.0%         0.0%         0.0%         0.0%      |   5.1%         2.6%         0.0%         0.0%      |
|TERMINAL (d)           |  0/21 (0%)    0/15 (0%)    0/15 (0%)    0/13 (0%)  |  0/30 (0%)    1/38 (3%)    0/32 (0%)    0/38 (0%)  |
|FIRST INCIDENCE (DAYS) |   ---          ---          ---          ---       |   370          735 (T)      ---          ---       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |    (e)          (e)          (e)          (e)      |  P=0.093N     P=0.453N     P=0.230N     P=0.222N   |
|INCIDENTAL TUMOR       |    (e)          (e)          (e)          (e)      |  P=0.120N     P=0.661N     P=0.336N     P=0.362N   |
|LOGISTIC REGRESSION    |    (e)          (e)          (e)          (e)      |  P=0.094N     P=0.657N     P=0.343N     P=0.216N   |
|COCHRAN-ARMITAGE       |    (e)                                             |  P=0.101N                                          |
|FISHER EXACT           |                 (e)          (e)          (e)      |               P=0.500N     P=0.247N     P=0.247N   |
|=================================================================================================================================|
         DATE: 04/04/96                     EXPERIMENT: 05182 TEST: 03                                                 PAGE  26
                             STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- PHENOLPHTHALEIN
                                                 TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   0 PPM        12000        25000        50000     |   0 PPM        12000        25000        50000     |
|                       |                PPM          PPM          PPM       |                PPM          PPM          PPM       |
|=================================================================================================================================|
|                                                                                                                                 |
|Uterus                                                                                                                           |
|     Polyp Stromal                                                                                                               |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |                                                    |  4/50 (8%)    8/50 (16%)   6/50 (12%)   5/50 (10%) |
|ADJUSTED (b)           |                                                    |  12.6%        19.6%        17.8%        12.7%      |
|TERMINAL (d)           |                                                    |  3/30 (10%)   6/38 (16%)   5/32 (16%)   4/38 (11%) |
|FIRST INCIDENCE (DAYS) |                                                    |   700          435          697          697       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |                                                    |  P=0.431N     P=0.299      P=0.412      P=0.632    |
|INCIDENTAL TUMOR       |                                                    |  P=0.543N     P=0.188      P=0.402      P=0.463    |
|LOGISTIC REGRESSION    |                                                    |  P=0.533N     P=0.197      P=0.424      P=0.558    |
|COCHRAN-ARMITAGE       |                                                    |  P=0.539N                                          |
|FISHER EXACT           |                                                    |               P=0.178      P=0.370      P=0.500    |
|=================================================================================================================================|
|                                                                                                                                 |
|Uterus                                                                                                                           |
|     Sarcoma Stromal or Polyp Stromal                                                                                            |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |                                                    |  5/50 (10%)   8/50 (16%)   6/50 (12%)   5/50 (10%) |
|ADJUSTED (b)           |                                                    |  14.7%        19.6%        17.8%        12.7%      |
|TERMINAL (d)           |                                                    |  3/30 (10%)   6/38 (16%)   5/32 (16%)   4/38 (11%) |
|FIRST INCIDENCE (DAYS) |                                                    |   606          435          697          697       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |                                                    |  P=0.338N     P=0.422      P=0.547      P=0.504N   |
|INCIDENTAL TUMOR       |                                                    |  P=0.457N     P=0.267      P=0.544      P=0.544    |
|LOGISTIC REGRESSION    |                                                    |  P=0.434N     P=0.277      P=0.547      P=0.606N   |
|COCHRAN-ARMITAGE       |                                                    |  P=0.437N                                          |
|FISHER EXACT           |                                                    |               P=0.277      P=0.500      P=0.630N   |
|=================================================================================================================================|
         DATE: 04/04/96                     EXPERIMENT: 05182 TEST: 03                                                 PAGE  27
                             STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- PHENOLPHTHALEIN
                                                 TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   0 PPM        12000        25000        50000     |   0 PPM        12000        25000        50000     |
|                       |                PPM          PPM          PPM       |                PPM          PPM          PPM       |
|=================================================================================================================================|
|                                                                                                                                 |
|Zymbal's Gland                                                                                                                   |
|     Carcinoma                                                                                                                   |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #        |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  1/50 (2%)    0/50 (0%)    0/50 (0%)    2/50 (4%)  |  0/50 (0%)    1/50 (2%)    0/50 (0%)    0/50 (0%)  |
|ADJUSTED (b)           |   2.7%         0.0%         0.0%        10.0%      |   0.0%         2.6%         0.0%         0.0%      |
|TERMINAL (d)           |  0/21 (0%)    0/15 (0%)    0/15 (0%)    1/13 (8%)  |  0/30 (0%)    1/38 (3%)    0/32 (0%)    0/38 (0%)  |
|FIRST INCIDENCE (DAYS) |   577          ---          ---          612       |   ---          735 (T)      ---          ---       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.235      P=0.480N     P=0.461N     P=0.485    |  P=0.535N     P=0.547        (e)          (e)      |
|INCIDENTAL TUMOR       |  P=0.190      P=0.425N     P=0.519N     P=0.445    |  P=0.535N     P=0.547        (e)          (e)      |
|LOGISTIC REGRESSION    |  P=0.233      P=0.540N     P=0.530N     P=0.488    |  P=0.535N     P=0.547        (e)          (e)      |
|COCHRAN-ARMITAGE       |  P=0.243                                           |  P=0.559N                                          |
|FISHER EXACT           |               P=0.500N     P=0.500N     P=0.500    |               P=0.500        (e)          (e)      |
|=================================================================================================================================|
|                                                                                                                                 |
|Zymbal's Gland                                                                                                                   |
|     Carcinoma or Adenoma                                                                                                        |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #        |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  1/50 (2%)    0/50 (0%)    1/50 (2%)    2/50 (4%)  |  0/50 (0%)    1/50 (2%)    0/50 (0%)    0/50 (0%)  |
|ADJUSTED (b)           |   2.7%         0.0%         4.8%        10.0%      |   0.0%         2.6%         0.0%         0.0%      |
|TERMINAL (d)           |  0/21 (0%)    0/15 (0%)    0/15 (0%)    1/13 (8%)  |  0/30 (0%)    1/38 (3%)    0/32 (0%)    0/38 (0%)  |
|FIRST INCIDENCE (DAYS) |   577          ---          701          612       |   ---          735 (T)      ---          ---       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.223      P=0.480N     P=0.759      P=0.485    |  P=0.535N     P=0.547        (e)          (e)      |
|INCIDENTAL TUMOR       |  P=0.245      P=0.425N     P=0.677N     P=0.445    |  P=0.535N     P=0.547        (e)          (e)      |
|LOGISTIC REGRESSION    |  P=0.244      P=0.540N     P=0.760      P=0.488    |  P=0.535N     P=0.547        (e)          (e)      |
|COCHRAN-ARMITAGE       |  P=0.244                                           |  P=0.559N                                          |
|FISHER EXACT           |               P=0.500N     P=0.753N     P=0.500    |               P=0.500        (e)          (e)      |
|=================================================================================================================================|
         DATE: 04/04/96                     EXPERIMENT: 05182 TEST: 03                                                 PAGE  28
                             STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- PHENOLPHTHALEIN
                                                 TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   0 PPM        12000        25000        50000     |   0 PPM        12000        25000        50000     |
|                       |                PPM          PPM          PPM       |                PPM          PPM          PPM       |
|=================================================================================================================================|
|                                                                                                                                 |
|All Organs                                                                                                                       |
|     Leukemia: Lymphocytic, Monocytic, Mononuclear, or Undifferentiated                                                          |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #        |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            | 31/50 (62%)  27/50 (54%)  24/50 (48%)  29/50 (58%) | 21/50 (42%)  21/50 (42%)  17/50 (34%)  14/50 (28%) |
|ADJUSTED (b)           |  76.0%        67.6%        65.0%        87.4%      |  54.3%        44.4%        39.8%        31.4%      |
|TERMINAL (d)           | 12/21 (57%)   5/15 (33%)   5/15 (33%)  10/13 (77%) | 13/30 (43%)  12/38 (32%)   7/32 (22%)   8/38 (21%) |
|FIRST INCIDENCE (DAYS) |   330          458          383          524       |   515          549          601          434       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.448      P=0.503N     P=0.284N     P=0.412    |  P=0.040N*    P=0.285N     P=0.212N     P=0.046N*  |
|INCIDENTAL TUMOR       |  P=0.513N     P=0.209N     P=0.080N     P=0.531    |  P=0.200N     P=0.578      P=0.223N     P=0.235N   |
|LOGISTIC REGRESSION    |  P=0.457N     P=0.291N     P=0.116N     P=0.421N   |  P=0.107N     P=0.571N     P=0.224N     P=0.101N   |
|COCHRAN-ARMITAGE       |  P=0.416N                                          |  P=0.058N                                          |
|FISHER EXACT           |               P=0.272N     P=0.114N     P=0.419N   |               P=0.580N     P=0.268N     P=0.104N   |
|=================================================================================================================================|
|                                                                                                                                 |
|All Organs                                                                                                                       |
|     Mesothelioma: Benign, Malignant, NOS                                                                                        |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #        |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  2/50 (4%)    2/50 (4%)    0/50 (0%)    2/50 (4%)  |  0/50 (0%)    0/50 (0%)    0/50 (0%)    0/50 (0%)  |
|ADJUSTED (b)           |   8.4%         7.3%         0.0%         5.7%      |   0.0%         0.0%         0.0%         0.0%      |
|TERMINAL (d)           |  1/21 (5%)    0/15 (0%)    0/15 (0%)    0/13 (0%)  |  0/30 (0%)    0/38 (0%)    0/32 (0%)    0/38 (0%)  |
|FIRST INCIDENCE (DAYS) |   704          646          ---          636       |   ---          ---          ---          ---       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.564N     P=0.623      P=0.308N     P=0.651    |    (e)          (e)          (e)          (e)      |
|INCIDENTAL TUMOR       |  P=0.382N     P=0.595N     P=0.173N     P=0.572N   |    (e)          (e)          (e)          (e)      |
|LOGISTIC REGRESSION    |  P=0.541N     P=0.694      P=0.247N     P=0.682N   |    (e)          (e)          (e)          (e)      |
|COCHRAN-ARMITAGE       |  P=0.553N                                          |    (e)                                             |
|FISHER EXACT           |               P=0.691N     P=0.247N     P=0.691N   |                 (e)          (e)          (e)      |
|=================================================================================================================================|
         DATE: 04/04/96                     EXPERIMENT: 05182 TEST: 03                                                 PAGE  29
                             STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- PHENOLPHTHALEIN
                                                 TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   0 PPM        12000        25000        50000     |   0 PPM        12000        25000        50000     |
|                       |                PPM          PPM          PPM       |                PPM          PPM          PPM       |
|=================================================================================================================================|
|                                                                                                                                 |
|All Organs                                                                                                                       |
|     Benign Tumors                                                                                                               |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #        |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            | 47/50 (94%)  50/50 (100%) 49/50 (98%)  50/50 (100%)| 43/50 (86%)  49/50 (98%)  42/50 (84%)  41/50 (82%) |
|ADJUSTED (b)           | 100.0%       100.0%       100.0%       100.0%      | 100.0%       100.0%        95.4%        95.3%      |
|TERMINAL (d)           | 21/21 (100%) 15/15 (100%) 15/15 (100%) 13/13 (100%)| 30/30 (100%) 38/38 (100%) 30/32 (94%)  36/38 (95%) |
|FIRST INCIDENCE (DAYS) |   407          458          372          485       |   370          435          391          506       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.148      P=0.136      P=0.219      P=0.107    |  P=0.014N*    P=0.289N     P=0.281N     P=0.016N*  |
|INCIDENTAL TUMOR       |  P=0.472      P=0.425      P=0.698N     P=0.500    |  P=0.129N     P=0.220      P=0.352N     P=0.391N   |
|LOGISTIC REGRESSION    |  P=0.354      P=0.456      P=0.480      P=0.602    |  P=0.126N     P=0.147      P=0.301N     P=0.335N   |
|COCHRAN-ARMITAGE       |  P=0.089                                           |  P=0.111N                                          |
|FISHER EXACT           |               P=0.121      P=0.309      P=0.121    |               P=0.030 *    P=0.500N     P=0.393N   |
|=================================================================================================================================|
|                                                                                                                                 |
|All Organs                                                                                                                       |
|     Malignant Tumors                                                                                                            |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #        |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            | 35/50 (70%)  36/50 (72%)  31/50 (62%)  33/50 (66%) | 30/50 (60%)  25/50 (50%)  21/50 (42%)  23/50 (46%) |
|ADJUSTED (b)           |  80.2%        84.2%        81.6%        89.6%      |  69.0%        52.9%        47.0%        47.5%      |
|TERMINAL (d)           | 13/21 (62%)   9/15 (60%)   9/15 (60%)  10/13 (77%) | 17/30 (57%)  16/38 (42%)   9/32 (28%)  13/38 (34%) |
|FIRST INCIDENCE (DAYS) |   330          458          383          524       |   370          549          568          271       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.467      P=0.297      P=0.491N     P=0.399    |  P=0.071N     P=0.066N     P=0.058N     P=0.055N   |
|INCIDENTAL TUMOR       |  P=0.291N     P=0.554N     P=0.199N     P=0.529N   |  P=0.151N     P=0.272N     P=0.045N*    P=0.146N   |
|LOGISTIC REGRESSION    |  P=0.297N     P=0.486      P=0.253N     P=0.420N   |  P=0.096N     P=0.239N     P=0.061N     P=0.127N   |
|COCHRAN-ARMITAGE       |  P=0.294N                                          |  P=0.103N                                          |
|FISHER EXACT           |               P=0.500      P=0.263N     P=0.415N   |               P=0.211N     P=0.055N     P=0.115N   |
|=================================================================================================================================|
         DATE: 04/04/96                     EXPERIMENT: 05182 TEST: 03                                                 PAGE  30
                             STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- PHENOLPHTHALEIN
                                                 TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   0 PPM        12000        25000        50000     |   0 PPM        12000        25000        50000     |
|                       |                PPM          PPM          PPM       |                PPM          PPM          PPM       |
|=================================================================================================================================|
|                                                                                                                                 |
|All Organs                                                                                                                       |
|     Malignant and Benign Tumors                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #        |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            | 49/50 (98%)  50/50 (100%) 50/50 (100%) 50/50 (100%)| 49/50 (98%)  50/50 (100%) 50/50 (100%) 49/50 (98%) |
|ADJUSTED (b)           | 100.0%       100.0%       100.0%       100.0%      | 100.0%       100.0%       100.0%        98.0%      |
|TERMINAL (d)           | 21/21 (100%) 15/15 (100%) 15/15 (100%) 13/13 (100%)| 30/30 (100%) 38/38 (100%) 32/32 (100%) 37/38 (97%) |
|FIRST INCIDENCE (DAYS) |   330          458          372          485       |   370          435          391          271       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.201      P=0.206      P=0.268      P=0.167    |  P=0.131N     P=0.073N     P=0.401N     P=0.086N   |
|INCIDENTAL TUMOR       |    (e)          (e)          (e)          (e)      |  P=0.627N     P=0.814      P=0.682      P=0.734    |
|LOGISTIC REGRESSION    |    (e)          (e)          (e)          (e)      |  P=0.627N     P=0.834      P=0.716      P=0.758    |
|COCHRAN-ARMITAGE       |  P=0.309                                           |  P=0.591N                                          |
|FISHER EXACT           |               P=0.500      P=0.500      P=0.500    |               P=0.500      P=0.500      P=0.753N   |
|=================================================================================================================================|
 (a)  Number of tumor-bearing animals / number of animals examined at site.
 (b)  Kaplan-Meier estimated lifetime tumor incidence after adjustment for 
      intercurrent mortality.
 (d)  Observed incidence at terminal kill.
 (f)  Beneath the control incidence are the P-values associated with the trend 
      test.  Beneath the dosed group incidence are the P-values corresponding to 
      pairwise comparisons between the controls and that dosed group.  The life
      table analysis regards tumors in animals dying  prior to terminal kill as
      being (directly or indirectly) the cause of death.  The incidental tumor 
      test regards these lesions as non-fatal.  Logistic regression is an alternative
      method for analyzing the incidence of non-fatal tumors.  The Cochran-Armitage
      and Fisher's exact tests compare directly the overall incidence rates.  
      For all tests, a negative trend is indicated by "N".
 (e)  Value of Statistic cannot be computed. 
 (I)  Interim sacrifice
 (T)  Terminal sacrifice
  #   Tumor rates based on number of animals necropsied.
  *   To the right of any statistical result, indicates significance at (P<=0.05).
  **  To the right of any statistical result, indicates significance at (P<=0.01).