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TDMS Study 05182-03 Pathology Tables

NTP Experiment-Test: 05182-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          PHENOLPHTHALEIN                                      Date: 10/23/95
Route: DOSED FEED                                                                                                 Time: 16:52:04

                                                           CORE STUDY




       Facility:  TSI Mason Research

       Chemical CAS #:  77-09-8

       Lock Date:  01/24/94

       Cage Range:  All

       Reasons For Removal:    All

       Removal Date Range:     All

       Treatment Groups:       Include All




































                                                              Page   1

NTP Experiment-Test: 05182-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          PHENOLPHTHALEIN                                      Date: 10/23/95  
Route: DOSED FEED                                                                                                 Time: 16:52:04  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 3| 6| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 3| 3| 7| 5| 3| 3| 3| 3| 3| 2| 3| 0| 0| 3| 2| 3| 3| 3| 0| 3| 3| 3| 3| 3| 3|             
                                           | 6| 6| 0| 0| 6| 5| 6| 5| 6| 3| 5| 2| 6| 5| 4| 6| 6| 6| 6| 6| 5| 6| 5| 5| 5|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    0 PPM                                  | 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4|             
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Parasite Metazoan                    |                            X                                             |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Edema                                |          3                                                               |             
      Inflammation, Acute                  |          2                                                               |             
      Parasite Metazoan                    |    X  X                                            X                     |             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  A  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +|             
      Edema                                |          3                                                               |             
      Necrosis                             |          3                                                               |             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  A  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  A  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis, Focal                   |                                                                          |             
      Basophilic Focus                     | X  X        X  X  X  X  X  X  X     X  X     X  X  X  X     X  X  X  X  X|             
      Clear Cell Focus                     |                                        X                                 |             
      Eosinophilic Focus                   |                   X     X                 X     X  X  X     X           X|             
      Fibrosis, Focal                      |                                                                         1|             
      Hematopoietic Cell Proliferation     |                                           2  2                           |             
      Hepatodiaphragmatic Nodule           |                         X                                               X|             
      Inflammation, Chronic                |                                                 2  1              2  1   |             
      Mixed Cell Focus                     | X  X        X  X  X  X        X     X  X     X  X  X              X  X   |             
      Necrosis                             |                            4        2                                    |             
      Bile Duct, Hyperplasia, Focal        |                                           2                              |             
      Centrilobular, Necrosis              |                                                                          |             
      Hepatocyte, Vacuolization Cytoplasmic|                                                                          |             
      Kupffer Cell, Hyperplasia, Diffuse   |                                           3                              |             
                                            __________________________________________________________________________|             
   Mesentery                               |       +  +                    +     +                                    |             
      Accessory Spleen                     |       X                                                                  |             
      Fat, Necrosis                        |          4                    2     3                                    |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +|             
      Acinus, Atrophy, Diffuse             |                            2                             3               |             
      Acinus, Atrophy, Focal               |             2  2                             1  1  2              1  2  1|             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Parotid Gland, Atrophy, Diffuse      |                                                                          |             
      Submandibular Gland, Atrophy, Diffuse|                                                          3               |             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic                |                                                                          |             
      Epithelium, Hyperplasia              |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +|             
      Erosion, Focal                       |          2                       2        2                              |             
      Glands, Cyst, Focal                  |             1        1                                         1     1  1|             
                                            __________________________________________________________________________|             
   Tongue                                  |                            +                                             |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   2                                                               
NTP Experiment-Test: 05182-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          PHENOLPHTHALEIN                                      Date: 10/23/95  
Route: DOSED FEED                                                                                                 Time: 16:52:04  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 3| 6| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 3| 3| 7| 5| 3| 3| 3| 3| 3| 2| 3| 0| 0| 3| 2| 3| 3| 3| 0| 3| 3| 3| 3| 3| 3|             
                                           | 6| 6| 0| 0| 6| 5| 6| 5| 6| 3| 5| 2| 6| 5| 4| 6| 6| 6| 6| 6| 5| 6| 5| 5| 5|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    0 PPM                                  | 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4|             
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Tooth                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood Vessel                            | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Aorta, Media, Mineralization         |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cardiomyopathy                       | 1              2  2  1  2  1  2  1     1     1  1  2        2  2  2  1  2|             
      Artery, Inflammation, Chronic        |                                                                          |             
      Atrium, Thrombosis                   |                                  3        4                              |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |                                           2                              |             
      Hyperplasia, Focal                   |             1                                                            |             
      Hypertrophy, Focal                   | 1                                      1                                 |             
      Pigmentation                         |                                  2                                       |             
      Vacuolization Cytoplasmic, Focal     | 1  1                                      4                              |             
      Bilateral, Hyperplasia, Focal        |                                                                          |             
      Bilateral, Necrosis                  |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Focal                   | 2                                      1                 1     3         |             
      Bilateral, Hyperplasia, Focal        |                                                                          |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +|             
      Metaplasia, Focal                    |                                                                2         |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  M  +  M  +  +  +  +  +  +  +  +  M  +  M  +  +  +  +  +  +  +|             
      Hyperplasia, Focal                   |                                                                          |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Pars Distalis, Angiectasis, Focal    |                                                                          |             
      Pars Distalis, Cyst                  |                                  1        2  2        1     2        1   |             
      Pars Distalis, Hyperplasia, Focal    |             3                                   3     2     4            |             
      Pars Distalis, Pigmentation          |                                                                          |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      C-Cell, Hyperplasia, Diffuse         |       2                                                                  |             
      C-Cell, Hyperplasia, Focal           |    2     1        2  3  2     1              1  2        1           2  2|             
      Follicle, Cyst                       |             1                                                            |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Clitoral Gland                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Focal                   |                                                                          |             
      Inflammation, Chronic                |       2              1                                   1        1      |             
      Inflammation, Chronic Active         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   3                                                               
NTP Experiment-Test: 05182-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          PHENOLPHTHALEIN                                      Date: 10/23/95  
Route: DOSED FEED                                                                                                 Time: 16:52:04  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 3| 6| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 3| 3| 7| 5| 3| 3| 3| 3| 3| 2| 3| 0| 0| 3| 2| 3| 3| 3| 0| 3| 3| 3| 3| 3| 3|             
                                           | 6| 6| 0| 0| 6| 5| 6| 5| 6| 3| 5| 2| 6| 5| 4| 6| 6| 6| 6| 6| 5| 6| 5| 5| 5|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    0 PPM                                  | 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4|             
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
      Bilateral, Atrophy                   |                                                                3         |             
      Duct, Hyperplasia, Focal             |                                                                          |             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Bursa, Cyst                          |                                                                          |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hydrometra                           |                                              2  2                 1      |             
      Endometrium, Atrophy                 |       3                                                                  |             
      Endometrium, Inflammation, Acute     |          1                                                               |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                                                                          |             
      Hyperplasia                          |                                           2                              |             
      Myelofibrosis                        | 4     2                 1                                         2      |             
                                            __________________________________________________________________________|             
   Lymph Node                              |                                  +                 +                     |             
      Mediastinal, Hemorrhage              |                                                                          |             
      Renal, Infiltration Cellular,        |                                                                          |             
          Histiocyte                       |                                                    3                     |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Degeneration, Cystic                 |    2              1                          2                          2|             
      Hemorrhage                           |                                                                         1|             
      Hyperplasia, Lymphoid                |    2  2              3  3  1                 2  2     2           2      |             
      Infiltration Cellular, Histiocyte    |                                        1                             1  2|             
      Necrosis                             |          3                                                               |             
      Pigmentation                         |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +|             
      Degeneration, Cystic                 |                                                                      3   |             
      Ectasia                              | 1                                                                        |             
      Hemorrhage                           |                      2                                                   |             
      Hyperplasia, Lymphoid                |       3                                                              4   |             
      Infiltration Cellular, Histiocyte    |    2        1  1  1  2  2  2  2        2  3  1  2  2  2  3  2     2     1|             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrosis                             |                                                                2         |             
      Hematopoietic Cell Proliferation     | 1                       1           2     3  3                           |             
      Pigmentation                         | 2                    1                          2                       1|             
      Lymphoid Follicle, Atrophy           |                                                                          |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |                                                                          |             
      Hyperplasia, Lymphoid                |                                                                         2|             
      Epithelial Cell, Hyperplasia         |    2           2  2     2     1  2     2     2  1  2  1  2        1      |             
      Thymocyte, Atrophy                   |    3        3  2  4  2  3        4        4  4           4  1     4  2   |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page   4                                                               
NTP Experiment-Test: 05182-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          PHENOLPHTHALEIN                                      Date: 10/23/95  
Route: DOSED FEED                                                                                                 Time: 16:52:04  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 3| 6| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 3| 3| 7| 5| 3| 3| 3| 3| 3| 2| 3| 0| 0| 3| 2| 3| 3| 3| 0| 3| 3| 3| 3| 3| 3|             
                                           | 6| 6| 0| 0| 6| 5| 6| 5| 6| 3| 5| 2| 6| 5| 4| 6| 6| 6| 6| 6| 5| 6| 5| 5| 5|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    0 PPM                                  | 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4|             
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Galactocele                          | 1        2  2  1        1        1  1                          2     2   |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Femur, Fibrous Osteodystrophy        |                                                                          |             
      Femur, Hyperostosis                  |                                  2                                       |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hydrocephalus                        | 1                                                                        |             
                                            __________________________________________________________________________|             
   Peripheral Nerve                        |                                                                          |             
      Sciatic, Degeneration                |                                                                          |             
                                            __________________________________________________________________________|             
   Spinal Cord                             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           | 2              2                                                         |             
      Inflammation, Chronic Active         |                                           3                              |             
      Alveolar Epithelium, Hyperplasia,    |                                                                          |             
           Focal                           |                               2                       1                 1|             
      Interstitium, Inflammation, Chronic  |    1  2                 1                             1                  |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic                |                                                                          |             
      Inflammation, Chronic Active         |                         2                                                |             
      Nasolacrimal Duct, Inflammation,     |                                                                          |             
           Chronic                         |                                              2                           |             
      Olfactory Epithelium, Cytoplasmic    |                                                                          |             
          Alteration                       |                                                       1     1           1|             
      Turbinate, Congestion                |                                                                          |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Acute                  |                         2                                                |             
      Inflammation, Chronic                |       2                                                                  |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                      +                                                   |             
      Cornea, Inflammation, Chronic        |                      1                                                   |             
      Lens, Cataract                       |                      2                                                   |             
      Retina, Atrophy                      |                      4                                                   |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrosis, Focal                      |             2                                                            |             
      Inflammation, Acute                  |                                           4                              |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   5                                                               
NTP Experiment-Test: 05182-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          PHENOLPHTHALEIN                                      Date: 10/23/95  
Route: DOSED FEED                                                                                                 Time: 16:52:04  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 3| 6| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 3| 3| 7| 5| 3| 3| 3| 3| 3| 2| 3| 0| 0| 3| 2| 3| 3| 3| 0| 3| 3| 3| 3| 3| 3|             
                                           | 6| 6| 0| 0| 6| 5| 6| 5| 6| 3| 5| 2| 6| 5| 4| 6| 6| 6| 6| 6| 5| 6| 5| 5| 5|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    0 PPM                                  | 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4|             
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
      Mineralization, Focal                |                                                                          |             
      Nephropathy, Chronic                 |    1                                                        1        1   |             
      Bilateral, Mineralization, Focal     |                   1              1  1                 1                  |             
      Bilateral, Nephropathy, Chronic      | 2     1     2     1  1  1     1        2     1  1  1           2  1      |             
      Bilateral, Pelvis, Dilatation        |                                                                          |             
      Bilateral, Pelvis, Inflammation,     |                                                                          |             
           Acute                           |                                                                          |             
      Bilateral, Pelvis, Inflammation,     |                                                                          |             
           Chronic Active                  |             2                                                            |             
      Bilateral, Pelvis, Transitional      |                                                                          |             
          Epithelium, Hyperplasia          |             2                                                            |             
      Bilateral, Renal Tubule, Pigmentation| 1                    2                             1     3     1        1|             
      Papilla, Necrosis                    |          3                                                               |             
      Renal Tubule, Degeneration           |                                                                          |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +|             
      Infiltration Cellular, Focal,        |                                                                          |             
          Lymphocyte                       | 1                                                                        |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   6                                                               
NTP Experiment-Test: 05182-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          PHENOLPHTHALEIN                                      Date: 10/23/95  
Route: DOSED FEED                                                                                                 Time: 16:52:04  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 7| 5| 6| 7| 7| 7| 7| 4| 4| 6| 6| 6| 6| 7| 7| 3| 7| 7| 7| 7| 7| 5| 7| 7|            |
                             DAY ON TEST   | 1| 3| 5| 8| 3| 3| 3| 0| 0| 3| 8| 4| 0| 5| 3| 3| 7| 3| 0| 3| 3| 3| 9| 3| 3|            |
                                           | 5| 6| 9| 3| 5| 5| 6| 9| 4| 9| 7| 8| 5| 9| 5| 6| 0| 5| 0| 5| 6| 5| 4| 6| 6|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|      A     |
    0 PPM                                  | 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6|      L     |
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  A  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Parasite Metazoan                    |                                                                          |      1     |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Edema                                |                                                                          |      1  3.0|
      Inflammation, Acute                  |                                                                          |      1  2.0|
      Parasite Metazoan                    |             X                                                            |      4     |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  A  +  +  +  A  A  +  +  +  +  +  +  +  +  +  +  +  +|  45        |
      Edema                                |                                                                          |      1  3.0|
      Necrosis                             |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  A  A  +  +  +  +  +  +  +  +  +  +  +  +|  46        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  A  +  +  +  A  A  A  +  +  +  +  +  +  +  +  +  +  +|  44        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  A  A  +  +  +  +  +  +  +  +  +  +  +  +|  47        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Angiectasis, Focal                   |                                                             2            |      1  2.0|
      Basophilic Focus                     |    X  X     X     X        X                 X     X  X  X     X  X     X|     32     |
      Clear Cell Focus                     |                                              X                           |      2     |
      Eosinophilic Focus                   |                   X                    X     X                 X         |     12     |
      Fibrosis, Focal                      |                                                                          |      1  1.0|
      Hematopoietic Cell Proliferation     |                         1                                                |      3  1.7|
      Hepatodiaphragmatic Nodule           |                                                 X                        |      3     |
      Inflammation, Chronic                |                                                 1           1     2      |      7  1.4|
      Mixed Cell Focus                     |    X              X  X  X  X           X           X  X        X  X     X|     25     |
      Necrosis                             |                                                                          |      2  3.0|
      Bile Duct, Hyperplasia, Focal        |                                                                          |      1  2.0|
      Centrilobular, Necrosis              |                                  2                                       |      1  2.0|
      Hepatocyte, Vacuolization Cytoplasmic|                      4                                1           2      |      3  2.3|
      Kupffer Cell, Hyperplasia, Diffuse   |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Mesentery                               |       +  +        +  +                       +              +        +  +|  12        |
      Accessory Spleen                     |                                                                          |      1     |
      Fat, Necrosis                        |       2  4        2                          2              2        2  2|     10  2.5|
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Acinus, Atrophy, Diffuse             |                   4        3                                             |      4  3.0|
      Acinus, Atrophy, Focal               | 2  1     2  1        2        3                    1  2        1         |     17  1.6|
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Parotid Gland, Atrophy, Diffuse      |          4              3                                                |      2  3.5|
      Submandibular Gland, Atrophy, Diffuse|                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Inflammation, Chronic                |                                                       2                  |      1  2.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page   7                                                               
NTP Experiment-Test: 05182-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          PHENOLPHTHALEIN                                      Date: 10/23/95  
Route: DOSED FEED                                                                                                 Time: 16:52:04  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 7| 5| 6| 7| 7| 7| 7| 4| 4| 6| 6| 6| 6| 7| 7| 3| 7| 7| 7| 7| 7| 5| 7| 7|            |
                             DAY ON TEST   | 1| 3| 5| 8| 3| 3| 3| 0| 0| 3| 8| 4| 0| 5| 3| 3| 7| 3| 0| 3| 3| 3| 9| 3| 3|            |
                                           | 5| 6| 9| 3| 5| 5| 6| 9| 4| 9| 7| 8| 5| 9| 5| 6| 0| 5| 0| 5| 6| 5| 4| 6| 6|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|      A     |
    0 PPM                                  | 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6|      L     |
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
                                           |                                                                          |            |
      Epithelium, Hyperplasia              |          2                                            2           2  2   |      4  2.0|
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Erosion, Focal                       | 2        1                             2                                 |      6  1.8|
      Glands, Cyst, Focal                  |    1                          1                          1               |      8  1.0|
                                            __________________________________________________________________________|____________|
   Tongue                                  |                                                 +                        |   2        |
                                            __________________________________________________________________________|____________|
   Tooth                                   |                         +                                                |   1        |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood Vessel                            | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Aorta, Media, Mineralization         |                      3                                                   |      1  3.0|
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cardiomyopathy                       |    1  1  1  2     1  2     3  1  1  2     1  2        2  1  1  1  2  2  2|     36  1.5|
      Artery, Inflammation, Chronic        |                                                    2                     |      1  2.0|
      Atrium, Thrombosis                   |                                                                          |      2  3.5|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hemorrhage                           |                                                                          |      1  2.0|
      Hyperplasia, Focal                   |                   1                                                      |      2  1.0|
      Hypertrophy, Focal                   |                                                                          |      2  1.0|
      Pigmentation                         |                                                                          |      1  2.0|
      Vacuolization Cytoplasmic, Focal     |    2     3                                1                              |      6  2.0|
      Bilateral, Hyperplasia, Focal        |                               2                                          |      1  2.0|
      Bilateral, Necrosis                  |                2                                         1               |      2  1.5|
                                            __________________________________________________________________________|____________|
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia, Focal                   |                   1                    1                       1     2  2|      9  1.6|
      Bilateral, Hyperplasia, Focal        |                1                                                         |      1  1.0|
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Metaplasia, Focal                    |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  46        |
      Hyperplasia, Focal                   |                                                                         2|      1  2.0|
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Pars Distalis, Angiectasis, Focal    |                                  1                                       |      1  1.0|
      Pars Distalis, Cyst                  | 2     2  2        3     2  1                    1           1            |     14  1.6|
      Pars Distalis, Hyperplasia, Focal    |                                                             4            |      5  3.2|
      Pars Distalis, Pigmentation          |             2                                                            |      1  2.0|
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      C-Cell, Hyperplasia, Diffuse         |                                                                          |      1  2.0|
      C-Cell, Hyperplasia, Focal           |    1  1  2                                1  1        4  2  3        3   |     20  1.9|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page   8                                                               
NTP Experiment-Test: 05182-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          PHENOLPHTHALEIN                                      Date: 10/23/95  
Route: DOSED FEED                                                                                                 Time: 16:52:04  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 7| 5| 6| 7| 7| 7| 7| 4| 4| 6| 6| 6| 6| 7| 7| 3| 7| 7| 7| 7| 7| 5| 7| 7|            |
                             DAY ON TEST   | 1| 3| 5| 8| 3| 3| 3| 0| 0| 3| 8| 4| 0| 5| 3| 3| 7| 3| 0| 3| 3| 3| 9| 3| 3|            |
                                           | 5| 6| 9| 3| 5| 5| 6| 9| 4| 9| 7| 8| 5| 9| 5| 6| 0| 5| 0| 5| 6| 5| 4| 6| 6|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|      A     |
    0 PPM                                  | 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6|      L     |
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
                                           |                                                                          |            |
      Follicle, Cyst                       |                                                                          |      1  1.0|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Clitoral Gland                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia, Focal                   |                                                                2         |      1  2.0|
      Inflammation, Chronic                |                                                                          |      4  1.3|
      Inflammation, Chronic Active         |       2     3                                            4               |      3  3.0|
      Bilateral, Atrophy                   |                                                                          |      1  3.0|
      Duct, Hyperplasia, Focal             |                      2                                                   |      1  2.0|
                                            __________________________________________________________________________|____________|
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Bursa, Cyst                          |                   2                                                      |      1  2.0|
                                            __________________________________________________________________________|____________|
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hydrometra                           |                                              2                           |      4  1.8|
      Endometrium, Atrophy                 |                                                                          |      1  3.0|
      Endometrium, Inflammation, Acute     |          4                                                               |      2  2.5|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Atrophy                              |       2                                                                  |      1  2.0|
      Hyperplasia                          |                      2                    2              1  1  2         |      6  1.7|
      Myelofibrosis                        |                                                             1            |      5  2.0|
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +        +           +              +  +                                 |   7        |
      Mediastinal, Hemorrhage              |          2                                                               |      1  2.0|
      Renal, Infiltration Cellular,        |                                                                          |            |
          Histiocyte                       |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Degeneration, Cystic                 |                                                 1              1         |      6  1.5|
      Hemorrhage                           |                                  2                                       |      2  1.5|
      Hyperplasia, Lymphoid                |       2           2     2                                      2  1      |     14  2.0|
      Infiltration Cellular, Histiocyte    |                                                       1                  |      4  1.3|
      Necrosis                             |                                                                          |      1  3.0|
      Pigmentation                         |                                                       2                  |      1  2.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Degeneration, Cystic                 |                                              3                           |      2  3.0|
      Ectasia                              |                                                                          |      1  1.0|
      Hemorrhage                           |                                                                          |      1  2.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page   9                                                               
NTP Experiment-Test: 05182-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          PHENOLPHTHALEIN                                      Date: 10/23/95  
Route: DOSED FEED                                                                                                 Time: 16:52:04  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 7| 5| 6| 7| 7| 7| 7| 4| 4| 6| 6| 6| 6| 7| 7| 3| 7| 7| 7| 7| 7| 5| 7| 7|            |
                             DAY ON TEST   | 1| 3| 5| 8| 3| 3| 3| 0| 0| 3| 8| 4| 0| 5| 3| 3| 7| 3| 0| 3| 3| 3| 9| 3| 3|            |
                                           | 5| 6| 9| 3| 5| 5| 6| 9| 4| 9| 7| 8| 5| 9| 5| 6| 0| 5| 0| 5| 6| 5| 4| 6| 6|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|      A     |
    0 PPM                                  | 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6|      L     |
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
      Hyperplasia, Lymphoid                |                                                                          |      2  3.5|
      Infiltration Cellular, Histiocyte    |       2  2  2  2  1     2                       2  2  2     1  1  2      |     30  1.8|
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Fibrosis                             |                                                                          |      1  2.0|
      Hematopoietic Cell Proliferation     |                      2  2                                      2  1      |      9  1.9|
      Pigmentation                         |       1           1                                   3           1      |      8  1.5|
      Lymphoid Follicle, Atrophy           |                      2     2     4                                       |      3  2.7|
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hemorrhage                           |                                           2                              |      1  2.0|
      Hyperplasia, Lymphoid                |                                                                          |      1  2.0|
      Epithelial Cell, Hyperplasia         | 2  2        1                             2           2  1     2         |     20  1.7|
      Thymocyte, Atrophy                   |    1     4           4  2     1  4                 3  4                  |     21  3.0|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Galactocele                          |    2     3     1              1           1  2     1  3  1  2  2  4  2   |     22  1.7|
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Femur, Fibrous Osteodystrophy        |                      2                                                   |      1  2.0|
      Femur, Hyperostosis                  | 2                          2  4  4                       3           2   |      7  2.7|
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hydrocephalus                        |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Peripheral Nerve                        |       +                                                                  |   1        |
      Sciatic, Degeneration                |       3                                                                  |      1  3.0|
                                            __________________________________________________________________________|____________|
   Spinal Cord                             |       +                                                                  |   1        |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hemorrhage                           |                                                                          |      2  2.0|
      Inflammation, Chronic Active         |                                                                          |      1  3.0|
      Alveolar Epithelium, Hyperplasia,    |                                                                          |            |
           Focal                           |                                                                1         |      4  1.3|
      Interstitium, Inflammation, Chronic  |       1           1                                                      |      6  1.2|
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inflammation, Chronic                |       1     1                                1  1           2            |      5  1.2|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  10                                                               
NTP Experiment-Test: 05182-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          PHENOLPHTHALEIN                                      Date: 10/23/95  
Route: DOSED FEED                                                                                                 Time: 16:52:04  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 7| 5| 6| 7| 7| 7| 7| 4| 4| 6| 6| 6| 6| 7| 7| 3| 7| 7| 7| 7| 7| 5| 7| 7|            |
                             DAY ON TEST   | 1| 3| 5| 8| 3| 3| 3| 0| 0| 3| 8| 4| 0| 5| 3| 3| 7| 3| 0| 3| 3| 3| 9| 3| 3|            |
                                           | 5| 6| 9| 3| 5| 5| 6| 9| 4| 9| 7| 8| 5| 9| 5| 6| 0| 5| 0| 5| 6| 5| 4| 6| 6|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|      A     |
    0 PPM                                  | 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6|      L     |
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 RESPIRATORY SYSTEM - cont                 |                                                                          |            |
                                           |                                                                          |            |
      Inflammation, Chronic Active         |                                                                          |      1  2.0|
      Nasolacrimal Duct, Inflammation,     |                                                                          |            |
           Chronic                         |                                                                          |      1  2.0|
      Olfactory Epithelium, Cytoplasmic    |                                                                          |            |
          Alteration                       |                                                                          |      3  1.0|
      Turbinate, Congestion                |                            3                                             |      1  3.0|
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inflammation, Acute                  |                                                                          |      1  2.0|
      Inflammation, Chronic                |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Eye                                     |                                                                   +      |   2        |
      Cornea, Inflammation, Chronic        |                                                                          |      1  1.0|
      Lens, Cataract                       |                                                                          |      1  2.0|
      Retina, Atrophy                      |                                                                          |      1  4.0|
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Fibrosis, Focal                      |                                                                          |      1  2.0|
      Inflammation, Acute                  |                                                                          |      1  4.0|
      Mineralization, Focal                |                            1                    1        1               |      3  1.0|
      Nephropathy, Chronic                 |                         1                                                |      4  1.0|
      Bilateral, Mineralization, Focal     |             1  1                                                  1      |      7  1.0|
      Bilateral, Nephropathy, Chronic      |    1  1  1     1  1  1     1              1  1     1  2  1  1  2  1  2  1|     30  1.2|
      Bilateral, Pelvis, Dilatation        |                      4                                                   |      1  4.0|
      Bilateral, Pelvis, Inflammation,     |                                                                          |            |
           Acute                           |          2                                                               |      1  2.0|
      Bilateral, Pelvis, Inflammation,     |                                                                          |            |
           Chronic Active                  |                                                                          |      1  2.0|
      Bilateral, Pelvis, Transitional      |                                                                          |            |
          Epithelium, Hyperplasia          |                                                       1                  |      2  1.5|
      Bilateral, Renal Tubule, Pigmentation|             1  1              3                       2              2   |     11  1.6|
      Papilla, Necrosis                    |                                                                          |      1  3.0|
      Renal Tubule, Degeneration           |                      4                                                   |      1  4.0|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Infiltration Cellular, Focal,        |                                                                          |            |
          Lymphocyte                       |                                                                          |      1  1.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  11                                                               
NTP Experiment-Test: 05182-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          PHENOLPHTHALEIN                                      Date: 10/23/95  
Route: DOSED FEED                                                                                                 Time: 16:52:04  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 6| 7| 7| 5| 6| 7| 7| 7|             
                             DAY ON TEST   | 3| 7| 3| 3| 3| 3| 3| 3| 1| 3| 2| 3| 3| 3| 3| 7| 3| 7| 3| 3| 7| 7| 3| 3| 3|             
                                           | 6| 9| 6| 5| 6| 6| 5| 5| 7| 5| 8| 6| 6| 6| 6| 4| 6| 9| 6| 6| 1| 5| 5| 6| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    12000                                  | 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9|             
    PPM                                    | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Parasite Metazoan                    |       X                    X                                             |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Edema                                |    2                                                                     |             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic                |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis, Focal                   |                                     2                                2   |             
      Basophilic Focus                     | X        X     X  X  X     X     X  X  X        X        X     X  X  X  X|             
      Clear Cell Focus                     |                   X                                                      |             
      Cytoplasmic Alteration, Focal        |                                     3                                    |             
      Eosinophilic Focus                   |                      X                    X     X  X                 X   |             
      Hematopoietic Cell Proliferation     |                                                          1     2         |             
      Hepatodiaphragmatic Nodule           | X                          X                    X        X               |             
      Infiltration Cellular, Focal,        |                                                                          |             
          Lymphocyte                       |                                                                          |             
      Inflammation, Chronic                |                                        1           2                     |             
      Mixed Cell Focus                     |                X  X  X     X     X  X     X     X              X  X  X   |             
      Hepatocyte, Vacuolization Cytoplasmic|                                                                1         |             
                                            __________________________________________________________________________|             
   Mesentery                               |    +                          +                 +                        |             
      Fat, Necrosis                        |    3                          2                 2                        |             
                                            __________________________________________________________________________|             
   Oral Mucosa                             |                         +           +                                    |             
      Ulcer                                |                                     3                                    |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Acinus, Atrophy, Diffuse             |                                                                          |             
      Acinus, Atrophy, Focal               | 2        1  1  1     1  1        1              2        3  2        2  1|             
      Acinus, Basophilic Focus             |                   X                                                      |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy, Diffuse                     |                               2                                          |             
      Infiltration Cellular, Focal,        |                                                                          |             
          Lymphocyte                       |                                     1                                    |             
      Parotid Gland, Atrophy, Focal        |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic                |                               2                                2         |             
      Epithelium, Hyperplasia              |                               2                                2         |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Erosion, Focal                       |                               2                                          |             
      Glands, Cyst, Focal                  |          1  1  1              1        1  1                 1     1      |             
                                            __________________________________________________________________________|             
   Tongue                                  |                +  +              +                                       |             
      Capillary, Erosion, Focal            |                2                                                         |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  12                                                               
NTP Experiment-Test: 05182-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          PHENOLPHTHALEIN                                      Date: 10/23/95  
Route: DOSED FEED                                                                                                 Time: 16:52:04  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 6| 7| 7| 5| 6| 7| 7| 7|             
                             DAY ON TEST   | 3| 7| 3| 3| 3| 3| 3| 3| 1| 3| 2| 3| 3| 3| 3| 7| 3| 7| 3| 3| 7| 7| 3| 3| 3|             
                                           | 6| 9| 6| 5| 6| 6| 5| 5| 7| 5| 8| 6| 6| 6| 6| 4| 6| 9| 6| 6| 1| 5| 5| 6| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    12000                                  | 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9|             
    PPM                                    | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood Vessel                            | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cardiomyopathy                       | 1  1              2        1        1  1     1  1  1  2  2        1  1  1|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Focal                   | 2                                               2                        |             
      Hypertrophy, Focal                   |                                  2                                       |             
      Vacuolization Cytoplasmic, Focal     | 1  1  1     2  1              2                 1  2           1         |             
      Bilateral, Hematopoietic Cell        |                                                                          |             
          Proliferation                    |                                                                          |             
      Bilateral, Hyperplasia, Focal        |             2                                                            |             
      Bilateral, Necrosis                  |                         4                                                |             
                                            __________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Focal                   |                               1        1                 3              2|             
      Infiltration Cellular, Lymphocyte    |                                                                          |             
      Bilateral, Hyperplasia, Focal        |    2        2                                                            |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Metaplasia, Focal                    |                                                                          |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  M  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Focal                   |                                                                          |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Pars Distalis, Angiectasis, Focal    |                                                                      3   |             
      Pars Distalis, Cyst                  |    2  2           2     1           2  2              2  1               |             
      Pars Distalis, Hyperplasia, Focal    |                                                                          |             
      Rathke's Cleft, Cyst                 |                                                                          |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Ultimobranchial Cyst                 |                                                                          |             
      C-Cell, Hyperplasia, Focal           | 1     1        2        1  2                       1           3     2   |             
      Follicle, Cyst                       |             2                                                            |             
      Follicle, Hyperplasia, Focal         |          2                                                               |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Peritoneum                              |                                        +                                 |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Clitoral Gland                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                                                          |             
      Hyperplasia, Focal                   |             3              2           2                                 |             
      Inflammation, Chronic                |                                                          2        2      |             
      Inflammation, Chronic Active         |                                                                          |             
      Bilateral, Atrophy                   |                               2                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  13                                                               
NTP Experiment-Test: 05182-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          PHENOLPHTHALEIN                                      Date: 10/23/95  
Route: DOSED FEED                                                                                                 Time: 16:52:04  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 6| 7| 7| 5| 6| 7| 7| 7|             
                             DAY ON TEST   | 3| 7| 3| 3| 3| 3| 3| 3| 1| 3| 2| 3| 3| 3| 3| 7| 3| 7| 3| 3| 7| 7| 3| 3| 3|             
                                           | 6| 9| 6| 5| 6| 6| 5| 5| 7| 5| 8| 6| 6| 6| 6| 4| 6| 9| 6| 6| 1| 5| 5| 6| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    12000                                  | 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9|             
    PPM                                    | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
      Duct, Inflammation, Acute            |                                        1                                 |             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Bilateral, Pigmentation              |                                                                          |             
      Bursa, Cyst                          |    3                 4        3                                          |             
      Follicle, Cyst                       |                                     2                 2                  |             
      Periovarian Tissue, Cyst             | 2                                                                        |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hydrometra                           | 2                                1  4                                    |             
      Inflammation, Chronic Active         |                                                                          |             
      Necrosis                             |                                                                          |             
      Endometrium, Cyst                    |                                                          1               |             
                                            __________________________________________________________________________|             
   Vagina                                  |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                                                                          |             
      Hyperplasia                          |             2                       2              2     2     1     1   |             
      Myelofibrosis                        |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node                              |    +  +                 +     +              +        +     +            |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Degeneration, Cystic                 |                1  1                 3           1                       1|             
      Hyperplasia, Lymphoid                | 2                                                                       1|             
      Infiltration Cellular, Histiocyte    |                            1                                             |             
      Pigmentation                         |                                           1                              |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Degeneration, Cystic                 |                                                                          |             
      Hemorrhage                           |                                                                1         |             
      Infiltration Cellular, Histiocyte    | 1        2  1  1  2  2     1  2  1  1  1  1     1  1     2     2  2  1   |             
      Pigmentation                         |                                                                      2   |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hematopoietic Cell Proliferation     |                      1     1                             2     3     1  1|             
      Pigmentation                         |                   1                       1        2                     |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                  1                                       |             
      Epithelial Cell, Hyperplasia         | 2  1  2  2  2  2  1  2     2     2  1  2  1     1     1  2        2  1  2|             
      Thymocyte, Atrophy                   | 2           2     3     3  2  3     4              2  4  3     4  4      |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Galactocele                          |    2           4     1        2                                2         |             
      Inflammation, Chronic                |                                                       2                  |             
      Epithelium, Hyperplasia              |                                              2                           |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  14                                                               
NTP Experiment-Test: 05182-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          PHENOLPHTHALEIN                                      Date: 10/23/95  
Route: DOSED FEED                                                                                                 Time: 16:52:04  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 6| 7| 7| 5| 6| 7| 7| 7|             
                             DAY ON TEST   | 3| 7| 3| 3| 3| 3| 3| 3| 1| 3| 2| 3| 3| 3| 3| 7| 3| 7| 3| 3| 7| 7| 3| 3| 3|             
                                           | 6| 9| 6| 5| 6| 6| 5| 5| 7| 5| 8| 6| 6| 6| 6| 4| 6| 9| 6| 6| 1| 5| 5| 6| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    12000                                  | 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9|             
    PPM                                    | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM - cont             |                                                                          |             
                                           |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Acute                  |                                     1                                    |             
      Femur, Hyperostosis                  |                                              4                           |             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |                                                    +        +            |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hydrocephalus                        |                                                    2                     |             
      Cerebellum, Hemorrhage, Focal        |                                                                          |             
      Cerebrum, Hemorrhage, Focal          |                                                                          |             
      Pons, Hemorrhage, Focal              |                                                                2         |             
      Thalamus, Cerebrum, Necrosis         |                                                                          |             
                                            __________________________________________________________________________|             
   Peripheral Nerve                        |                                                    +        +            |             
                                            __________________________________________________________________________|             
   Spinal Cord                             |                                                    +        +            |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |                                                                          |             
      Infiltration Cellular, Focal,        |                                                                          |             
          Lymphocyte                       |                                                                          |             
      Alveolar Epithelium, Hyperplasia,    |                                                                          |             
           Focal                           |                1                    1                                    |             
      Interstitium, Inflammation, Chronic  |                   1                             1        1               |             
      Interstitium, Inflammation, Chronic  |                                                                          |             
          Active                           |                1                                                         |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Acute                  |                                           1                              |             
      Inflammation, Chronic                |    2                             2                                       |             
      Inflammation, Chronic Active         |       2     2     3     3                                                |             
      Nasolacrimal Duct, Inflammation,     |                                                                          |             
           Acute                           |          2                                                               |             
      Olfactory Epithelium, Cytoplasmic    |                                                                          |             
          Alteration                       |                      1        2                                      2   |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic                |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                                     +                                    |             
      Atrophy                              |                                     4                                    |             
                                            __________________________________________________________________________|             
   Zymbal's Gland                          |                                     +                                    |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  15                                                               
NTP Experiment-Test: 05182-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          PHENOLPHTHALEIN                                      Date: 10/23/95  
Route: DOSED FEED                                                                                                 Time: 16:52:04  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 6| 7| 7| 5| 6| 7| 7| 7|             
                             DAY ON TEST   | 3| 7| 3| 3| 3| 3| 3| 3| 1| 3| 2| 3| 3| 3| 3| 7| 3| 7| 3| 3| 7| 7| 3| 3| 3|             
                                           | 6| 9| 6| 5| 6| 6| 5| 5| 7| 5| 8| 6| 6| 6| 6| 4| 6| 9| 6| 6| 1| 5| 5| 6| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    12000                                  | 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9|             
    PPM                                    | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
      Cyst                                 |                                                                          |             
      Fibrosis, Focal                      |                      3                                                   |             
      Mineralization, Focal                |                                                                         1|             
      Nephropathy, Chronic                 |                                     1                                    |             
      Bilateral, Mineralization, Focal     |                               1                                1  1      |             
      Bilateral, Nephropathy, Chronic      | 2  1  1  1  3  2  2  2     1  1  1     1  2  1  1  1  1     1  2  1  1  2|             
      Bilateral, Renal Tubule, Pigmentation|    1                                                  2  1  3        1   |             
      Pelvis, Inflammation, Acute          |                      1                                                   |             
      Pelvis, Transitional Epithelium,     |                                                                          |             
           Hyperplasia                     |                                                                          |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  16                                                               
NTP Experiment-Test: 05182-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          PHENOLPHTHALEIN                                      Date: 10/23/95  
Route: DOSED FEED                                                                                                 Time: 16:52:04  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 4| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 5| 7| 7|            |
                             DAY ON TEST   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 0| 3| 3| 3| 1| 3| 7| 3| 3| 3| 3| 4| 3| 3|            |
                                           | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 8| 5| 3| 5| 5| 5| 5| 9| 5| 5|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|      A     |
    12000                                  | 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1|      L     |
    PPM                                    | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +|  49        |
      Parasite Metazoan                    |                                                                          |      2     |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  A  +  +|  47        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +|  49        |
      Edema                                |                                  2           2                           |      3  2.0|
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +|  49        |
      Inflammation, Chronic                |                               1                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Angiectasis, Focal                   |                                     2                                   2|      4  2.0|
      Basophilic Focus                     | X     X  X  X  X     X  X  X  X     X  X  X     X     X  X  X  X     X  X|     34     |
      Clear Cell Focus                     |                               X                                         X|      3     |
      Cytoplasmic Alteration, Focal        |                                                                          |      1  3.0|
      Eosinophilic Focus                   |       X     X           X           X  X  X              X               |     12     |
      Hematopoietic Cell Proliferation     |                                                                          |      2  1.5|
      Hepatodiaphragmatic Nodule           |             X                          X                          X      |      7     |
      Infiltration Cellular, Focal,        |                                                                          |            |
          Lymphocyte                       |                                                             1            |      1  1.0|
      Inflammation, Chronic                |                                                          1               |      3  1.3|
      Mixed Cell Focus                     | X              X           X  X        X  X     X     X  X     X     X  X|     23     |
      Hepatocyte, Vacuolization Cytoplasmic|                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Mesentery                               |                            +     +  +                             +      |   7        |
      Fat, Necrosis                        |                            2     2  2                             3      |      7  2.3|
                                            __________________________________________________________________________|____________|
   Oral Mucosa                             |                                                                +         |   3        |
      Ulcer                                |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +|  49        |
      Acinus, Atrophy, Diffuse             |                                                 3                        |      1  3.0|
      Acinus, Atrophy, Focal               |    1  1  1  2     2  3     1     2  1  1  1        1     2  1  2     1   |     28  1.5|
      Acinus, Basophilic Focus             |                                                                          |      1     |
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Atrophy, Diffuse                     |                                                                          |      1  2.0|
      Infiltration Cellular, Focal,        |                                                                          |            |
          Lymphocyte                       |                                                                          |      1  1.0|
      Parotid Gland, Atrophy, Focal        |                                           2                              |      1  2.0|
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inflammation, Chronic                |                                                                          |      2  2.0|
      Epithelium, Hyperplasia              |                                                                   3      |      3  2.3|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  17                                                               
NTP Experiment-Test: 05182-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          PHENOLPHTHALEIN                                      Date: 10/23/95  
Route: DOSED FEED                                                                                                 Time: 16:52:04  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 4| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 5| 7| 7|            |
                             DAY ON TEST   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 0| 3| 3| 3| 1| 3| 7| 3| 3| 3| 3| 4| 3| 3|            |
                                           | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 8| 5| 3| 5| 5| 5| 5| 9| 5| 5|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|      A     |
    12000                                  | 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1|      L     |
    PPM                                    | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Erosion, Focal                       |                                     1                                    |      2  1.5|
      Glands, Cyst, Focal                  |                         1                                                |      9  1.0|
                                            __________________________________________________________________________|____________|
   Tongue                                  |                                                                          |   3        |
      Capillary, Erosion, Focal            |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood Vessel                            | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cardiomyopathy                       | 2     2  1  2  3  1  2  1  1  2  2     1  2           1  2  1        1  1|     32  1.4|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia, Focal                   |                1                    2                       1            |      5  1.6|
      Hypertrophy, Focal                   |                                                                          |      1  2.0|
      Vacuolization Cytoplasmic, Focal     |    1     2        2  1  1                    1  1     1                  |     17  1.3|
      Bilateral, Hematopoietic Cell        |                                                                          |            |
          Proliferation                    |                                                                      1   |      1  1.0|
      Bilateral, Hyperplasia, Focal        |                                                                          |      1  2.0|
      Bilateral, Necrosis                  |                                              2                           |      2  3.0|
                                            __________________________________________________________________________|____________|
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia, Focal                   | 1        2        1  1              2     2     2     3     2        1   |     14  1.7|
      Infiltration Cellular, Lymphocyte    |                                                             3            |      1  3.0|
      Bilateral, Hyperplasia, Focal        |                3                                   3                     |      4  2.5|
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +|  49        |
      Metaplasia, Focal                    |                2                                                         |      1  2.0|
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +|  46        |
      Hyperplasia, Focal                   |                                        3                                 |      1  3.0|
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Pars Distalis, Angiectasis, Focal    |                                                                          |      1  3.0|
      Pars Distalis, Cyst                  |          2  2           2        2  1  2     1                 2     2   |     17  1.8|
      Pars Distalis, Hyperplasia, Focal    |             2        2                                                   |      2  2.0|
      Rathke's Cleft, Cyst                 |                                  3                                       |      1  3.0|
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Ultimobranchial Cyst                 |                                  1                                       |      1  1.0|
      C-Cell, Hyperplasia, Focal           |       4     1     1     3  4           1  1  1                       1  2|     18  1.8|
      Follicle, Cyst                       |                                                                          |      1  2.0|
      Follicle, Hyperplasia, Focal         |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  18                                                               
NTP Experiment-Test: 05182-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          PHENOLPHTHALEIN                                      Date: 10/23/95  
Route: DOSED FEED                                                                                                 Time: 16:52:04  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 4| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 5| 7| 7|            |
                             DAY ON TEST   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 0| 3| 3| 3| 1| 3| 7| 3| 3| 3| 3| 4| 3| 3|            |
                                           | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 8| 5| 3| 5| 5| 5| 5| 9| 5| 5|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|      A     |
    12000                                  | 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1|      L     |
    PPM                                    | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 GENERAL BODY SYSTEM - cont                |                                                                          |            |
                                           |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Peritoneum                              |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Clitoral Gland                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cyst                                 |                                     3                                    |      1  3.0|
      Hyperplasia, Focal                   |                                                 4                        |      4  2.8|
      Inflammation, Chronic                |                                     1                             2      |      4  1.8|
      Inflammation, Chronic Active         |                                           1                    1     2   |      3  1.3|
      Bilateral, Atrophy                   |                                              2                           |      2  2.0|
      Duct, Inflammation, Acute            |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Bilateral, Pigmentation              |                                              2                           |      1  2.0|
      Bursa, Cyst                          |    4                                                                     |      4  3.5|
      Follicle, Cyst                       |                                                                          |      2  2.0|
      Periovarian Tissue, Cyst             |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hydrometra                           |                                        2                                 |      4  2.3|
      Inflammation, Chronic Active         |                         3                                                |      1  3.0|
      Necrosis                             |    3                                                                     |      1  3.0|
      Endometrium, Cyst                    |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Vagina                                  |    +                                                                     |   1        |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Atrophy                              |       1                                                                  |      1  1.0|
      Hyperplasia                          |    2           2                                      1                  |      9  1.7|
      Myelofibrosis                        |                               1                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Lymph Node                              |                +                 +           +                    +      |  11        |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Degeneration, Cystic                 |       1                 2                       2     1        1        1|     11  1.4|
      Hyperplasia, Lymphoid                |          1                                      4                        |      4  2.0|
      Infiltration Cellular, Histiocyte    |                               1                                      1   |      3  1.0|
      Pigmentation                         |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Degeneration, Cystic                 |                                                             2            |      1  2.0|
      Hemorrhage                           |                         1                                                |      2  1.0|
      Infiltration Cellular, Histiocyte    |       1  1  2  1     1        1        1  1     1     1  2  1  1     2  2|     33  1.3|
      Pigmentation                         |                                                                          |      1  2.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  19                                                               
NTP Experiment-Test: 05182-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          PHENOLPHTHALEIN                                      Date: 10/23/95  
Route: DOSED FEED                                                                                                 Time: 16:52:04  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 4| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 5| 7| 7|            |
                             DAY ON TEST   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 0| 3| 3| 3| 1| 3| 7| 3| 3| 3| 3| 4| 3| 3|            |
                                           | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 8| 5| 3| 5| 5| 5| 5| 9| 5| 5|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|      A     |
    12000                                  | 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1|      L     |
    PPM                                    | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hematopoietic Cell Proliferation     |                                                 2                        |      7  1.6|
      Pigmentation                         | 1        1                                                  1  1         |      7  1.1|
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +|  49        |
      Cyst                                 |                                                                          |      1  1.0|
      Epithelial Cell, Hyperplasia         | 1        2           2  1  1  1     2  2  2     1     1  2     2     2  2|     34  1.6|
      Thymocyte, Atrophy                   | 2  2           2              2     2  2                       2         |     19  2.6|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Galactocele                          |             1  2  1                 1     2  2  1  3  1           4      |     15  1.9|
      Inflammation, Chronic                |                                  2                                       |      2  2.0|
      Epithelium, Hyperplasia              |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inflammation, Acute                  |                                                                          |      1  1.0|
      Femur, Hyperostosis                  |                                  2                                       |      2  3.0|
                                            __________________________________________________________________________|____________|
   Skeletal Muscle                         |                      +                                                   |   3        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hydrocephalus                        |                                                                          |      1  2.0|
      Cerebellum, Hemorrhage, Focal        |                                              1                           |      1  1.0|
      Cerebrum, Hemorrhage, Focal          |                                              1                           |      1  1.0|
      Pons, Hemorrhage, Focal              |                                                                          |      1  2.0|
      Thalamus, Cerebrum, Necrosis         |                                     3                                    |      1  3.0|
                                            __________________________________________________________________________|____________|
   Peripheral Nerve                        |                                                                          |   2        |
                                            __________________________________________________________________________|____________|
   Spinal Cord                             |                                                                          |   2        |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hemorrhage                           |                                                                1         |      1  1.0|
      Infiltration Cellular, Focal,        |                                                                          |            |
          Lymphocyte                       |                                                       2                  |      1  2.0|
      Alveolar Epithelium, Hyperplasia,    |                                                                          |            |
           Focal                           |                   2  4                                                  3|      5  2.2|
      Interstitium, Inflammation, Chronic  |       1     1                                                            |      5  1.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  20                                                               
NTP Experiment-Test: 05182-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          PHENOLPHTHALEIN                                      Date: 10/23/95  
Route: DOSED FEED                                                                                                 Time: 16:52:04  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 4| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 5| 7| 7|            |
                             DAY ON TEST   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 0| 3| 3| 3| 1| 3| 7| 3| 3| 3| 3| 4| 3| 3|            |
                                           | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 8| 5| 3| 5| 5| 5| 5| 9| 5| 5|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|      A     |
    12000                                  | 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1|      L     |
    PPM                                    | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 RESPIRATORY SYSTEM - cont                 |                                                                          |            |
                                           |                                                                          |            |
      Interstitium, Inflammation, Chronic  |                                                                          |            |
          Active                           |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Inflammation, Acute                  |                                                                          |      1  1.0|
      Inflammation, Chronic                |                                                                          |      2  2.0|
      Inflammation, Chronic Active         | 2                                               2                        |      6  2.3|
      Nasolacrimal Duct, Inflammation,     |                                                                          |            |
           Acute                           |                                              2                           |      2  2.0|
      Olfactory Epithelium, Cytoplasmic    |                                                                          |            |
          Alteration                       |                      1     1     2                                       |      6  1.5|
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inflammation, Chronic                |          1                                1                 1            |      3  1.0|
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Eye                                     |                                                                          |   1        |
      Atrophy                              |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Zymbal's Gland                          |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cyst                                 |          4                                                              2|      2  3.0|
      Fibrosis, Focal                      |                                                                          |      1  3.0|
      Mineralization, Focal                |          1                                      1                        |      3  1.0|
      Nephropathy, Chronic                 |                                                                          |      1  1.0|
      Bilateral, Mineralization, Focal     |                1              1                                          |      5  1.0|
      Bilateral, Nephropathy, Chronic      | 2     1  2  1  1  1  1  1  2  1  2  1  1  1  1  2     1  1  2  2     2  2|     44  1.4|
      Bilateral, Renal Tubule, Pigmentation|       2           2              3           2                           |      9  1.9|
      Pelvis, Inflammation, Acute          |                      1                                                   |      2  1.0|
      Pelvis, Transitional Epithelium,     |                                                                          |            |
           Hyperplasia                     |                                                          1               |      1  1.0|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +|  49        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  21                                                               
NTP Experiment-Test: 05182-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          PHENOLPHTHALEIN                                      Date: 10/23/95  
Route: DOSED FEED                                                                                                 Time: 16:52:04  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 6| 7| 5| 7| 7| 7| 7| 7| 7| 5| 7|             
                             DAY ON TEST   | 3| 0| 3| 3| 3| 3| 3| 3| 0| 3| 1| 3| 3| 2| 4| 3| 0| 3| 3| 3| 3| 3| 3| 6| 3|             
                                           | 5| 1| 5| 6| 6| 5| 5| 6| 8| 5| 7| 5| 5| 9| 7| 5| 3| 5| 5| 5| 5| 5| 5| 8| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    25000                                  | 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4|             
    PPM                                    | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Parasite Metazoan                    |                                                             X            |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +|             
      Necrosis                             |                                                 4                        |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis, Focal                   | 2                                                                       2|             
      Basophilic Focus                     | X     X     X  X  X  X     X  X  X  X        X     X  X        X  X  X   |             
      Clear Cell Focus                     |                      X                                X                  |             
      Eosinophilic Focus                   | X     X                    X  X           X                    X        X|             
      Hematopoietic Cell Proliferation     |                                                                          |             
      Hepatodiaphragmatic Nodule           | X              X                                X        X               |             
      Inflammation, Chronic                |                1                                   1                     |             
      Mixed Cell Focus                     | X           X  X  X  X     X     X  X     X  X     X  X  X  X  X         |             
      Necrosis                             |                                                 1                        |             
      Hepatocyte, Vacuolization Cytoplasmic|                                                                          |             
                                            __________________________________________________________________________|             
   Mesentery                               |    +           +  +              +                                       |             
      Fat, Necrosis                        |    3           3  2              2                                       |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Acinus, Atrophy, Diffuse             |                                                                          |             
      Acinus, Atrophy, Focal               |       1  3  1  1  1  1  1     2     2  2  1        1  2     1     2  2  1|             
      Acinus, Hyperplasia, Focal           |                                                                3         |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Parotid Gland, Atrophy, Focal        |                                        2                       2         |             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic                |                         2                                                |             
      Ulcer, Focal                         |                               2        3                                 |             
      Epithelium, Hyperplasia              |          1              2     2                                          |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Erosion, Focal                       |                                                 2                        |             
      Inflammation, Chronic                |                                                                          |             
      Glands, Cyst, Focal                  |    1  1     1        1  1                          1  1  1               |             
      Serosa, Inflammation, Acute          |                                                                          |             
                                            __________________________________________________________________________|             
   Tooth                                   |                                                                          |             
      Developmental Malformation           |                                                                          |             
      Gingiva, Inflammation, Chronic       |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood Vessel                            | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  22                                                               
NTP Experiment-Test: 05182-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          PHENOLPHTHALEIN                                      Date: 10/23/95  
Route: DOSED FEED                                                                                                 Time: 16:52:04  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 6| 7| 5| 7| 7| 7| 7| 7| 7| 5| 7|             
                             DAY ON TEST   | 3| 0| 3| 3| 3| 3| 3| 3| 0| 3| 1| 3| 3| 2| 4| 3| 0| 3| 3| 3| 3| 3| 3| 6| 3|             
                                           | 5| 1| 5| 6| 6| 5| 5| 6| 8| 5| 7| 5| 5| 9| 7| 5| 3| 5| 5| 5| 5| 5| 5| 8| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    25000                                  | 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4|             
    PPM                                    | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |             
                                           |                                                                          |             
      Cardiomyopathy                       | 1        1  1     1  1     1     1  2  2     2              1  2     2  2|             
      Myocardium, Inflammation, Acute,     |                                                                          |             
           Focal                           |    1                                                                     |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Focal                   |          2     1                 2                    1        2         |             
      Hypertrophy, Focal                   |                                                                          |             
      Vacuolization Cytoplasmic, Focal     | 1  2     2     2                    2  2  1              1  2     1      |             
      Bilateral, Hyperplasia, Focal        |                                                                          |             
      Bilateral, Necrosis                  |                                                                          |             
      Bilateral, Vacuolization Cytoplasmic,|                                                                          |             
           Focal                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Focal                   | 1        2  2     2     1     1                    1                    4|             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  +  +  M  M  M  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Focal                   |                                                       2                  |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Pars Distalis, Angiectasis, Focal    |                                                                          |             
      Pars Distalis, Cyst                  |       1  2  2  2     2  2              2     2     2  1     1     2      |             
      Pars Distalis, Hyperplasia, Focal    |                                              1                           |             
      Pars Distalis, Pigmentation          |                                                                          |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      C-Cell, Hyperplasia, Focal           |          1  4  2  1     1                             1        2  1     3|             
      Follicle, Cyst                       |                                                                1         |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Clitoral Gland                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                                                          |             
      Hyperplasia, Focal                   |                                                                          |             
      Inflammation, Chronic                |    2  1  2                       1  1                    2           1   |             
      Inflammation, Chronic Active         |                                                                          |             
      Bilateral, Hyperplasia, Focal        |          3                                                               |             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                                                          |             
      Bursa, Cyst                          |    4                             3                                       |             
      Follicle, Cyst                       |                                                                          |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hydrometra                           |                      1              3                                    |             
      Endometrium, Cyst                    |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  23                                                               
NTP Experiment-Test: 05182-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          PHENOLPHTHALEIN                                      Date: 10/23/95  
Route: DOSED FEED                                                                                                 Time: 16:52:04  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 6| 7| 5| 7| 7| 7| 7| 7| 7| 5| 7|             
                             DAY ON TEST   | 3| 0| 3| 3| 3| 3| 3| 3| 0| 3| 1| 3| 3| 2| 4| 3| 0| 3| 3| 3| 3| 3| 3| 6| 3|             
                                           | 5| 1| 5| 6| 6| 5| 5| 6| 8| 5| 7| 5| 5| 9| 7| 5| 3| 5| 5| 5| 5| 5| 5| 8| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    25000                                  | 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4|             
    PPM                                    | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                            1                                      1      |             
      Hyperplasia                          |       2                                         2                        |             
      Myelofibrosis                        |                                                    2                     |             
                                            __________________________________________________________________________|             
   Lymph Node                              |    +     +                             +        +                       +|             
      Iliac, Hemorrhage                    |    3                                                                     |             
      Iliac, Hyperplasia, Lymphoid         |                                                 1                        |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Degeneration, Cystic                 |                                                                          |             
      Hyperplasia, Lymphoid                | 2           2                    1        1                              |             
      Infiltration Cellular, Histiocyte    |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Degeneration, Cystic                 |                                              2                           |             
      Hemorrhage                           |                                           2                              |             
      Infiltration Cellular, Histiocyte    | 2     2  2  1  1     1     1  1  2  1     1     2  2  2     2  1  2  2   |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hematopoietic Cell Proliferation     |                                                 1  1                     |             
      Pigmentation                         |                            2  1              1              1            |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                                                          |             
      Hemorrhage                           |                                                 2                        |             
      Epithelial Cell, Hyperplasia         | 2     1     2  2  2  2  1  2     2        2  2     2  2  2  2            |             
      Thymocyte, Atrophy                   | 3     3     3  2  3  2     2  2           2        3     2     2         |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +|             
      Galactocele                          |    4     2        1                                                      |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +|             
      Subcutaneous Tissue, Fibrosis, Focal |                                                                          |             
      Subcutaneous Tissue, Inflammation,   |                                                                          |             
           Acute                           |                                                 3                        |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Femur, Hyperostosis                  |    2                          2                                          |             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |                               +                 +                        |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hydrocephalus                        |                               1           2                             2|             
      Cerebrum, Hemorrhage, Focal          |                                                                          |             
                                            __________________________________________________________________________|             
   Peripheral Nerve                        |                               +                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  24                                                               
NTP Experiment-Test: 05182-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          PHENOLPHTHALEIN                                      Date: 10/23/95  
Route: DOSED FEED                                                                                                 Time: 16:52:04  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 6| 7| 5| 7| 7| 7| 7| 7| 7| 5| 7|             
                             DAY ON TEST   | 3| 0| 3| 3| 3| 3| 3| 3| 0| 3| 1| 3| 3| 2| 4| 3| 0| 3| 3| 3| 3| 3| 3| 6| 3|             
                                           | 5| 1| 5| 6| 6| 5| 5| 6| 8| 5| 7| 5| 5| 9| 7| 5| 3| 5| 5| 5| 5| 5| 5| 8| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    25000                                  | 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4|             
    PPM                                    | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Spinal Cord                             |                               +                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Foreign Body                         |                                                                          |             
      Hemorrhage                           | 2           1  2                                                     3   |             
      Interstitium, Inflammation, Chronic  | 1                          1                 1     1                     |             
      Serosa, Inflammation, Chronic        |                                                                          |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |                                                                      3   |             
      Inflammation, Acute                  |                                                                          |             
      Inflammation, Chronic                |                                                                          |             
      Inflammation, Chronic Active         |                   3                                                      |             
      Nasolacrimal Duct, Inflammation,     |                                                                          |             
           Acute                           |                               2                                         2|             
      Olfactory Epithelium, Cytoplasmic    |                                                                          |             
          Alteration                       |                      1                 1     1                           |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic                |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                            +     +                                       |             
      Cornea, Inflammation, Chronic        |                            1                                             |             
      Lens, Cataract                       |                            4     4                                       |             
      Retina, Atrophy                      |                            4     4                                       |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Acute                  |    2                                                                     |             
      Mineralization, Focal                |          1     1     1        1                                          |             
      Bilateral, Mineralization, Focal     |             1     1     1                 1                              |             
      Bilateral, Nephropathy, Chronic      | 1        1  2  2  2  1  2  2  2  1  2  1  2  1     1     1  1  2  2     1|             
      Bilateral, Pelvis, Mineralization,   |                                                                          |             
           Focal                           |                                                                         3|             
      Bilateral, Renal Tubule, Pigmentation|    2     2              2  2                                            2|             
      Pelvis, Dilatation                   |                                                                          |             
      Pelvis, Transitional Epithelium,     |                                                                          |             
           Hyperplasia                     |             1                                                            |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic                |          2                                                               |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  25                                                               
NTP Experiment-Test: 05182-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          PHENOLPHTHALEIN                                      Date: 10/23/95  
Route: DOSED FEED                                                                                                 Time: 16:52:04  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 6| 6| 7| 3| 7| 6| 7| 6| 7| 6| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 6|            |
                             DAY ON TEST   | 3| 3| 2| 6| 3| 9| 1| 9| 3| 1| 3| 9| 3| 3| 3| 3| 3| 3| 2| 2| 3| 3| 3| 3| 8|            |
                                           | 5| 5| 2| 1| 5| 1| 1| 7| 5| 6| 6| 0| 6| 6| 5| 6| 6| 5| 6| 4| 5| 6| 5| 6| 9|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|      A     |
    25000                                  | 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6|      L     |
    PPM                                    | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A|  49        |
      Parasite Metazoan                    |                                                             X            |      2     |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A|  48        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A|  47        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A|  49        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A|  47        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  A  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  A|  45        |
      Necrosis                             |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Angiectasis, Focal                   |                         2        1                                       |      4  1.8|
      Basophilic Focus                     | X  X  X     X           X  X  X  X  X  X  X  X  X  X        X  X  X  X   |     34     |
      Clear Cell Focus                     |    X                                                                     |      3     |
      Eosinophilic Focus                   |                                     X        X  X           X  X         |     12     |
      Hematopoietic Cell Proliferation     |                            1                                             |      1  1.0|
      Hepatodiaphragmatic Nodule           |       X                                   X                              |      6     |
      Inflammation, Chronic                |                                              1     1                     |      4  1.0|
      Mixed Cell Focus                     | X  X  X     X           X  X  X  X  X  X  X  X  X  X              X  X   |     31     |
      Necrosis                             |                                                                          |      1  1.0|
      Hepatocyte, Vacuolization Cytoplasmic|       1        1           2                                             |      3  1.3|
                                            __________________________________________________________________________|____________|
   Mesentery                               |                   +                 +                                    |   6        |
      Fat, Necrosis                        |                   2                 3                                    |      6  2.5|
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A|  49        |
      Acinus, Atrophy, Diffuse             |                            2                                             |      1  2.0|
      Acinus, Atrophy, Focal               | 1  1     2           1  1        1     1  1  1  2     1     2     2      |     30  1.4|
      Acinus, Hyperplasia, Focal           |                                     3                                    |      2  3.0|
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Parotid Gland, Atrophy, Focal        |                                                                          |      2  2.0|
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inflammation, Chronic                |                                                                          |      1  2.0|
      Ulcer, Focal                         |                   4                                                      |      3  3.0|
      Epithelium, Hyperplasia              |                2                                                         |      4  1.8|
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Erosion, Focal                       |                                                                          |      1  2.0|
      Inflammation, Chronic                |                                                             1            |      1  1.0|
      Glands, Cyst, Focal                  |       1                 1  1  1  1  1  1  1  1  1        1  1  1         |     21  1.0|
      Serosa, Inflammation, Acute          |                   2                                                      |      1  2.0|
                                            __________________________________________________________________________|____________|
   Tooth                                   |       +                                                           +      |   2        |
      Developmental Malformation           |       3                                                                  |      1  3.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  26                                                               
NTP Experiment-Test: 05182-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          PHENOLPHTHALEIN                                      Date: 10/23/95  
Route: DOSED FEED                                                                                                 Time: 16:52:04  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 6| 6| 7| 3| 7| 6| 7| 6| 7| 6| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 6|            |
                             DAY ON TEST   | 3| 3| 2| 6| 3| 9| 1| 9| 3| 1| 3| 9| 3| 3| 3| 3| 3| 3| 2| 2| 3| 3| 3| 3| 8|            |
                                           | 5| 5| 2| 1| 5| 1| 1| 7| 5| 6| 6| 0| 6| 6| 5| 6| 6| 5| 6| 4| 5| 6| 5| 6| 9|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|      A     |
    25000                                  | 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6|      L     |
    PPM                                    | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
                                           |                                                                          |            |
      Gingiva, Inflammation, Chronic       |                                                                   3      |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood Vessel                            | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cardiomyopathy                       | 1        2  2     1     1     1  1  1  2  1  2  1  2  1  1  1  2  1  2  1|     34  1.4|
      Myocardium, Inflammation, Acute,     |                                                                          |            |
           Focal                           |                                                                          |      1  1.0|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Hyperplasia, Focal                   |                                                                          |      5  1.6|
      Hypertrophy, Focal                   |                      3                                         1  4      |      3  2.7|
      Vacuolization Cytoplasmic, Focal     |       1  2        1           2  1                                2  2  1|     18  1.6|
      Bilateral, Hyperplasia, Focal        |                                                                   2      |      1  2.0|
      Bilateral, Necrosis                  |                                                          2               |      1  2.0|
      Bilateral, Vacuolization Cytoplasmic,|                                                                          |            |
           Focal                           |                                              3              1            |      2  2.0|
                                            __________________________________________________________________________|____________|
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia, Focal                   |                   3  3           1     1     1  3              1         |     15  1.8|
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A|  49        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  47        |
      Hyperplasia, Focal                   |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Pars Distalis, Angiectasis, Focal    |                      3                                                   |      1  3.0|
      Pars Distalis, Cyst                  |       2                       1           2                    1         |     16  1.7|
      Pars Distalis, Hyperplasia, Focal    |                               1                                          |      2  1.0|
      Pars Distalis, Pigmentation          |                   2                                                      |      1  2.0|
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      C-Cell, Hyperplasia, Focal           |                            1  2  3  2  4           1           1     1   |     17  1.8|
      Follicle, Cyst                       |             1                                                            |      2  1.0|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Clitoral Gland                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Cyst                                 |                                           4                              |      1  4.0|
      Hyperplasia, Focal                   |             3                             2  2                       3   |      4  2.5|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  27                                                               
NTP Experiment-Test: 05182-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          PHENOLPHTHALEIN                                      Date: 10/23/95  
Route: DOSED FEED                                                                                                 Time: 16:52:04  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 6| 6| 7| 3| 7| 6| 7| 6| 7| 6| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 6|            |
                             DAY ON TEST   | 3| 3| 2| 6| 3| 9| 1| 9| 3| 1| 3| 9| 3| 3| 3| 3| 3| 3| 2| 2| 3| 3| 3| 3| 8|            |
                                           | 5| 5| 2| 1| 5| 1| 1| 7| 5| 6| 6| 0| 6| 6| 5| 6| 6| 5| 6| 4| 5| 6| 5| 6| 9|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|      A     |
    25000                                  | 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6|      L     |
    PPM                                    | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 GENITAL SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
      Inflammation, Chronic                |                                                                      1   |      8  1.4|
      Inflammation, Chronic Active         |                               2                                          |      1  2.0|
      Bilateral, Hyperplasia, Focal        |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cyst                                 |          2                                                               |      1  2.0|
      Bursa, Cyst                          |                   3                                               2      |      4  3.0|
      Follicle, Cyst                       | 2                             2                                          |      2  2.0|
                                            __________________________________________________________________________|____________|
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hydrometra                           |                                                             2            |      3  2.0|
      Endometrium, Cyst                    |                                                                      1   |      1  1.0|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Atrophy                              |                         1                                                |      3  1.0|
      Hyperplasia                          |                            2              2                              |      4  2.0|
      Myelofibrosis                        |                1                                                         |      2  1.5|
                                            __________________________________________________________________________|____________|
   Lymph Node                              |          +                                            +  +              +|   9        |
      Iliac, Hemorrhage                    |                                                                          |      1  3.0|
      Iliac, Hyperplasia, Lymphoid         |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Degeneration, Cystic                 |                                              1  2                        |      2  1.5|
      Hyperplasia, Lymphoid                |                                  2                                2      |      6  1.7|
      Infiltration Cellular, Histiocyte    |                                                                      1   |      1  1.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A|  49        |
      Degeneration, Cystic                 |                                  3  2        1                           |      4  2.0|
      Hemorrhage                           |                   1                                                      |      2  1.5|
      Infiltration Cellular, Histiocyte    |    1        1  1        1  2  2     1     1     1  2        1     2  1   |     31  1.5|
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hematopoietic Cell Proliferation     |       1                    3        1                             1      |      6  1.3|
      Pigmentation                         |             1           1        1                 1        1        1   |     10  1.1|
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Cyst                                 |                                              1                           |      1  1.0|
      Hemorrhage                           |                                                                          |      1  2.0|
      Epithelial Cell, Hyperplasia         | 2  2        1           2  2  1  2  2        2  1  1     2  1  2  2  1   |     31  1.7|
      Thymocyte, Atrophy                   | 3     3           4        3        1           2  2     2               |     20  2.5|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Galactocele                          | 2     1                       1  2  1  1  1  2  1     1     1            |     14  1.5|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  28                                                               
NTP Experiment-Test: 05182-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          PHENOLPHTHALEIN                                      Date: 10/23/95  
Route: DOSED FEED                                                                                                 Time: 16:52:04  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 6| 6| 7| 3| 7| 6| 7| 6| 7| 6| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 6|            |
                             DAY ON TEST   | 3| 3| 2| 6| 3| 9| 1| 9| 3| 1| 3| 9| 3| 3| 3| 3| 3| 3| 2| 2| 3| 3| 3| 3| 8|            |
                                           | 5| 5| 2| 1| 5| 1| 1| 7| 5| 6| 6| 0| 6| 6| 5| 6| 6| 5| 6| 4| 5| 6| 5| 6| 9|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|      A     |
    25000                                  | 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6|      L     |
    PPM                                    | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 INTEGUMENTARY SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Subcutaneous Tissue, Fibrosis, Focal |                                                                   3      |      1  3.0|
      Subcutaneous Tissue, Inflammation,   |                                                                          |            |
           Acute                           |                                                                          |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Femur, Hyperostosis                  |                                                                   3      |      3  2.3|
                                            __________________________________________________________________________|____________|
   Skeletal Muscle                         |                                  +                                       |   3        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hydrocephalus                        |                                  2           1                           |      5  1.6|
      Cerebrum, Hemorrhage, Focal          |                      1                                                   |      1  1.0|
                                            __________________________________________________________________________|____________|
   Peripheral Nerve                        |                                  +                                       |   2        |
                                            __________________________________________________________________________|____________|
   Spinal Cord                             |                                  +                                       |   2        |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Foreign Body                         |                                  1                                       |      1  1.0|
      Hemorrhage                           | 1  2                          2                    1                     |      8  1.8|
      Interstitium, Inflammation, Chronic  |                                  2  1                                    |      6  1.2|
      Serosa, Inflammation, Chronic        |       2                                                                  |      1  2.0|
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hemorrhage                           |                                                                          |      1  3.0|
      Inflammation, Acute                  |          1                                                               |      1  1.0|
      Inflammation, Chronic                |                                              1                    2      |      2  1.5|
      Inflammation, Chronic Active         |                2                 2                                       |      3  2.3|
      Nasolacrimal Duct, Inflammation,     |                                                                          |            |
           Acute                           |                                                                          |      2  2.0|
      Olfactory Epithelium, Cytoplasmic    |                                                                          |            |
          Alteration                       |                                                                          |      3  1.0|
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inflammation, Chronic                |                                  2                    1                  |      2  1.5|
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Eye                                     |                                                                          |   2        |
      Cornea, Inflammation, Chronic        |                                                                          |      1  1.0|
      Lens, Cataract                       |                                                                          |      2  4.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  29                                                               
NTP Experiment-Test: 05182-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          PHENOLPHTHALEIN                                      Date: 10/23/95  
Route: DOSED FEED                                                                                                 Time: 16:52:04  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 6| 6| 7| 3| 7| 6| 7| 6| 7| 6| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 6|            |
                             DAY ON TEST   | 3| 3| 2| 6| 3| 9| 1| 9| 3| 1| 3| 9| 3| 3| 3| 3| 3| 3| 2| 2| 3| 3| 3| 3| 8|            |
                                           | 5| 5| 2| 1| 5| 1| 1| 7| 5| 6| 6| 0| 6| 6| 5| 6| 6| 5| 6| 4| 5| 6| 5| 6| 9|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|      A     |
    25000                                  | 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6|      L     |
    PPM                                    | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 SPECIAL SENSES SYSTEM - cont              |                                                                          |            |
                                           |                                                                          |            |
      Retina, Atrophy                      |                                                                          |      2  4.0|
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inflammation, Acute                  |                                                                          |      1  2.0|
      Mineralization, Focal                |             1                                                            |      5  1.0|
      Bilateral, Mineralization, Focal     |                            1     1  1  1  1                              |      9  1.0|
      Bilateral, Nephropathy, Chronic      | 1  2  1  2  1  1  1  1  1  2  2  2  1  1  1  2  2  2  2     2  1  2  2   |     43  1.5|
      Bilateral, Pelvis, Mineralization,   |                                                                          |            |
           Focal                           |                                                                          |      1  3.0|
      Bilateral, Renal Tubule, Pigmentation|                                        1                                2|      7  1.9|
      Pelvis, Dilatation                   |                            2                                             |      1  2.0|
      Pelvis, Transitional Epithelium,     |                                                                          |            |
           Hyperplasia                     |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A|  49        |
      Inflammation, Chronic                |                                                                          |      1  2.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  30                                                               
NTP Experiment-Test: 05182-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          PHENOLPHTHALEIN                                      Date: 10/23/95  
Route: DOSED FEED                                                                                                 Time: 16:52:04  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 2| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 4| 7| 7| 6|             
                             DAY ON TEST   | 3| 7| 3| 3| 3| 3| 3| 3| 1| 3| 1| 3| 0| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 2|             
                                           | 5| 1| 5| 5| 5| 6| 6| 5| 2| 5| 2| 5| 6| 5| 6| 6| 5| 6| 6| 6| 6| 4| 6| 5| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    50000                                  | 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9|             
    PPM                                    | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Parasite Metazoan                    |          X                                            X                  |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +|             
      Ulcer, Focal                         |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Ulcer, Focal                         |                                                                          |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +|             
      Basophilic Focus                     |    X  X  X  X  X  X  X           X  X     X  X  X  X  X  X  X     X  X   |             
      Clear Cell Focus                     |                                                                          |             
      Eosinophilic Focus                   |                            X                    X           X            |             
      Hematopoietic Cell Proliferation     |                                                                          |             
      Hepatodiaphragmatic Nodule           |       X              X                                   X               |             
      Hyperplasia, Focal                   |                                  2                                       |             
      Inflammation, Chronic                |                                                 1                        |             
      Mixed Cell Focus                     | X        X  X  X  X  X     X     X  X        X  X     X     X     X  X   |             
      Hepatocyte, Vacuolization Cytoplasmic|       1                                                              2   |             
                                            __________________________________________________________________________|             
   Mesentery                               |    +              +              +     +                                +|             
      Accessory Spleen                     |                                                                          |             
      Fat, Necrosis                        |    2              3              2     2                                 |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  M|             
      Acinus, Atrophy, Diffuse             |       4                                                                  |             
      Acinus, Atrophy, Focal               | 2  2     1  2        2                       1           1        1      |             
      Acinus, Hyperplasia, Focal           |                                                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Parotid Gland, Atrophy, Focal        |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Ulcer, Focal                         |                                                                          |             
      Epithelium, Hyperplasia              |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +|             
      Erosion, Focal                       |                               2                                          |             
      Glands, Cyst, Focal                  |                                              1     1                 1   |             
                                            __________________________________________________________________________|             
   Tongue                                  |                                                    +                     |             
      Capillary, Erosion, Focal            |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood Vessel                            | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cardiomyopathy                       | 1     1     1  1  1                    1        1  1  1           1  1   |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  31                                                               
NTP Experiment-Test: 05182-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          PHENOLPHTHALEIN                                      Date: 10/23/95  
Route: DOSED FEED                                                                                                 Time: 16:52:04  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 2| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 4| 7| 7| 6|             
                             DAY ON TEST   | 3| 7| 3| 3| 3| 3| 3| 3| 1| 3| 1| 3| 0| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 2|             
                                           | 5| 1| 5| 5| 5| 6| 6| 5| 2| 5| 2| 5| 6| 5| 6| 6| 5| 6| 6| 6| 6| 4| 6| 5| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    50000                                  | 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9|             
    PPM                                    | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +|             
      Hematopoietic Cell Proliferation     |                                                                          |             
      Hyperplasia, Focal                   |                1                             2                           |             
      Hypertrophy, Focal                   |                                  2                    4              2   |             
      Inflammation, Acute, Focal           |                                                                          |             
      Vacuolization Cytoplasmic, Focal     |       1  1     2        1                 2                              |             
      Bilateral, Hyperplasia, Focal        |                                                                   2      |             
      Bilateral, Vacuolization Cytoplasmic,|                                                                          |             
           Focal                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +|             
      Hyperplasia, Focal                   |                      2           1     1              1  1        3  1   |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  M  +  +  +  +  +  M  +|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +|             
      Pars Distalis, Angiectasis, Focal    |                                                                          |             
      Pars Distalis, Cyst                  |                      2        2                 1  2                     |             
      Pars Distalis, Hyperplasia, Focal    |                                           3                              |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +|             
      Ultimobranchial Cyst                 |    1                                                                     |             
      C-Cell, Hyperplasia, Focal           |          1           1        2           1        1                     |             
      Follicle, Cyst                       |                                                          2               |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Clitoral Gland                          | +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Focal                   |                                                             4            |             
      Inflammation, Chronic                |                1                                   1           1         |             
      Inflammation, Chronic Active         |                   1              1           1              2            |             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Bilateral, Atrophy                   |                                                                          |             
      Bilateral, Cyst                      |                                     3                                    |             
      Bursa, Cyst                          | 2                                                                        |             
      Follicle, Cyst                       |          1                                   2                           |             
                                            __________________________________________________________________________|             
   Oviduct                                 |                +                                                         |             
      Cyst                                 |                2                                                         |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hydrometra                           |    2                                                     2  2            |             
      Thrombosis                           |                                  3                                       |             
      Endometrium, Cyst                    |             1                          2        2                        |             
                                            __________________________________________________________________________|             
   Vagina                                  |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  32                                                               
NTP Experiment-Test: 05182-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          PHENOLPHTHALEIN                                      Date: 10/23/95  
Route: DOSED FEED                                                                                                 Time: 16:52:04  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 2| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 4| 7| 7| 6|             
                             DAY ON TEST   | 3| 7| 3| 3| 3| 3| 3| 3| 1| 3| 1| 3| 0| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 2|             
                                           | 5| 1| 5| 5| 5| 6| 6| 5| 2| 5| 2| 5| 6| 5| 6| 6| 5| 6| 6| 6| 6| 4| 6| 5| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    50000                                  | 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9|             
    PPM                                    | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              | 1                                   2        1                           |             
      Hyperplasia                          |                2        2        2                                       |             
      Myelofibrosis                        |    2                                      1                              |             
                                            __________________________________________________________________________|             
   Lymph Node                              |                      +        +                                         +|             
      Mediastinal, Hemorrhage              |                                                                          |             
      Mediastinal, Pigmentation            |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +|             
      Degeneration, Cystic                 | 1        1           1                                      1        1   |             
      Hemorrhage                           |                                     1                                    |             
      Hyperplasia, Lymphoid                |       2  2                                                           1   |             
      Infiltration Cellular, Histiocyte    |                                                                          |             
      Pigmentation                         |                   1                                                      |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +|             
      Degeneration, Cystic                 |                                                                          |             
      Hemorrhage                           |                                                                          |             
      Hyperplasia, Lymphoid                |                                                                          |             
      Infiltration Cellular, Histiocyte    | 1     1  1        2        1     2  1     1     2     1     1     2  1   |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Congestion                           |                                                                          |             
      Hematopoietic Cell Proliferation     |                1                 2                                       |             
      Pigmentation                         | 1        1                 1                                         1   |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |                                                                          |             
      Epithelial Cell, Hyperplasia         |             1        2           2     1  2  2  2  2     2  2     2  1   |             
      Thymocyte, Atrophy                   |       2              2     3     3        2     2        2     2  2      |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Galactocele                          |          2        2  1  2                 1  1        2     1            |             
      Epithelium, Hyperplasia              |          3                                                               |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Subcutaneous Tissue, Inflammation,   |                                                                          |             
           Chronic, Focal                  |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |    +                                                                     |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cerebrum, Hemorrhage, Focal          |                                                                          |             
      Meninges, Cerebrum, Hemorrhage       |                                                                          |             
                                            __________________________________________________________________________|             
   Peripheral Nerve                        |    +                                                                     |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  33                                                               
NTP Experiment-Test: 05182-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          PHENOLPHTHALEIN                                      Date: 10/23/95  
Route: DOSED FEED                                                                                                 Time: 16:52:04  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 2| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 4| 7| 7| 6|             
                             DAY ON TEST   | 3| 7| 3| 3| 3| 3| 3| 3| 1| 3| 1| 3| 0| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 2|             
                                           | 5| 1| 5| 5| 5| 6| 6| 5| 2| 5| 2| 5| 6| 5| 6| 6| 5| 6| 6| 6| 6| 4| 6| 5| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    50000                                  | 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9|             
    PPM                                    | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Spinal Cord                             |    +                                                                     |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |                                                 1                        |             
      Infiltration Cellular, Focal,        |                                                                          |             
          Histiocyte                       |                                                                          |             
      Interstitium, Inflammation, Chronic  |       1  1     1                                                         |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic                | 1  2     1                                                               |             
      Inflammation, Chronic Active         |                                        3                                 |             
      Nasolacrimal Duct, Inflammation,     |                                                                          |             
           Acute                           |                         2                                                |             
      Nasolacrimal Duct, Inflammation,     |                                                                          |             
           Chronic Active                  |                                                                          |             
      Olfactory Epithelium, Cytoplasmic    |                                                                          |             
          Alteration                       |                      1                                                   |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic                |                                                             1            |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Zymbal's Gland                          |                                                                          |             
      Cyst                                 |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                  2                                       |             
      Ectopic Liver                        |                                                                          |             
      Mineralization, Focal                |                                                                          |             
      Nephropathy, Chronic                 |                                                                          |             
      Bilateral, Mineralization, Focal     |                               1     1                                    |             
      Bilateral, Nephropathy, Chronic      | 1  1  3  2  2  1  2  1     2     2  2  3  1  1  3  2  1  1  2     1  2  1|             
      Bilateral, Renal Tubule,             |                                                                          |             
          Accumulation, Hyaline Droplet    |                      3                                               2   |             
      Bilateral, Renal Tubule, Pigmentation|                   1  3        1     1                                1   |             
                                            __________________________________________________________________________|             
   Ureter                                  |                                                             +            |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  34                                                               
NTP Experiment-Test: 05182-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          PHENOLPHTHALEIN                                      Date: 10/23/95  
Route: DOSED FEED                                                                                                 Time: 16:52:04  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 3| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 4| 7| 4| 7| 7| 7| 5| 7|            |
                             DAY ON TEST   | 3| 3| 3| 3| 3| 3| 9| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 9| 3| 8| 3| 3| 3| 8| 3|            |
                                           | 5| 5| 0| 5| 5| 5| 7| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 1| 5| 4| 5| 5| 5| 1| 5|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|      A     |
    50000                                  | 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1|      L     |
    PPM                                    | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Parasite Metazoan                    |                                                                          |      2     |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Ulcer, Focal                         |                         3                                                |      1  3.0|
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Ulcer, Focal                         |                         3                                                |      1  3.0|
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Basophilic Focus                     | X        X  X  X           X  X  X  X  X  X  X  X  X  X           X     X|     34     |
      Clear Cell Focus                     |                                  X                                       |      1     |
      Eosinophilic Focus                   |                                                             X            |      4     |
      Hematopoietic Cell Proliferation     |                                                    2                     |      1  2.0|
      Hepatodiaphragmatic Nodule           |                                        X                                 |      4     |
      Hyperplasia, Focal                   |                                                                          |      1  2.0|
      Inflammation, Chronic                |          1                                1                    1         |      4  1.0|
      Mixed Cell Focus                     | X  X     X  X  X           X  X     X  X  X  X  X     X     X  X  X  X  X|     33     |
      Hepatocyte, Vacuolization Cytoplasmic|       2                 2     1                 1                        |      6  1.5|
                                            __________________________________________________________________________|____________|
   Mesentery                               |          +                                         +                     |   7        |
      Accessory Spleen                     |                                                    X                     |      1     |
      Fat, Necrosis                        |          2                                                               |      5  2.2|
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  46        |
      Acinus, Atrophy, Diffuse             |                            4                                             |      2  4.0|
      Acinus, Atrophy, Focal               | 2  2  1  1  2                          1  1     1     3  2     2  1  1  2|     22  1.5|
      Acinus, Hyperplasia, Focal           | 2                                                                        |      1  2.0|
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Parotid Gland, Atrophy, Focal        |             2                                                            |      1  2.0|
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Ulcer, Focal                         |                      2                                                   |      1  2.0|
      Epithelium, Hyperplasia              |                   1  2                                                   |      2  1.5|
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Erosion, Focal                       |                      2                                                   |      2  2.0|
      Glands, Cyst, Focal                  |                                           1                              |      4  1.0|
                                            __________________________________________________________________________|____________|
   Tongue                                  |                                                       +                  |   2        |
      Capillary, Erosion, Focal            |                                                       2                  |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  35                                                               
NTP Experiment-Test: 05182-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          PHENOLPHTHALEIN                                      Date: 10/23/95  
Route: DOSED FEED                                                                                                 Time: 16:52:04  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 3| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 4| 7| 4| 7| 7| 7| 5| 7|            |
                             DAY ON TEST   | 3| 3| 3| 3| 3| 3| 9| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 9| 3| 8| 3| 3| 3| 8| 3|            |
                                           | 5| 5| 0| 5| 5| 5| 7| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 1| 5| 4| 5| 5| 5| 1| 5|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|      A     |
    50000                                  | 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1|      L     |
    PPM                                    | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood Vessel                            | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Cardiomyopathy                       | 1        2     2     2     1  2  3  1     1     2     1     1  1  3  1  1|     27  1.3|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Hematopoietic Cell Proliferation     |                                  1                                       |      1  1.0|
      Hyperplasia, Focal                   |    2     1                 1                                            2|      6  1.5|
      Hypertrophy, Focal                   |                                                                          |      3  2.7|
      Inflammation, Acute, Focal           |       2                                                                  |      1  2.0|
      Vacuolization Cytoplasmic, Focal     |    1                    2     2           2                       2      |     10  1.6|
      Bilateral, Hyperplasia, Focal        |                                                                          |      1  2.0|
      Bilateral, Vacuolization Cytoplasmic,|                                                                          |            |
           Focal                           |                2                                                         |      1  2.0|
                                            __________________________________________________________________________|____________|
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Hyperplasia, Focal                   |             1           3     3                 2                        |     11  1.7|
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  47        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +  M  +  M  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +|  44        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  47        |
      Pars Distalis, Angiectasis, Focal    |                      2     3     3              3                       2|      5  2.6|
      Pars Distalis, Cyst                  |       1        2     2        3                    1           1     2   |     11  1.7|
      Pars Distalis, Hyperplasia, Focal    |                               3                    2        4            |      4  3.0|
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Ultimobranchial Cyst                 |             2                                                            |      2  1.5|
      C-Cell, Hyperplasia, Focal           |    1     1                                3                 1            |      9  1.3|
      Follicle, Cyst                       |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Clitoral Gland                          | +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Hyperplasia, Focal                   |                                     3                          2         |      3  3.0|
      Inflammation, Chronic                |                         2           1                          1        1|      7  1.1|
      Inflammation, Chronic Active         |                                        3                                 |      5  1.6|
                                            __________________________________________________________________________|____________|
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Bilateral, Atrophy                   |                               2                                          |      1  2.0|
      Bilateral, Cyst                      |                                                                          |      1  3.0|
      Bursa, Cyst                          |          2                                      2           3     2     3|      6  2.3|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  36                                                               
NTP Experiment-Test: 05182-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          PHENOLPHTHALEIN                                      Date: 10/23/95  
Route: DOSED FEED                                                                                                 Time: 16:52:04  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 3| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 4| 7| 4| 7| 7| 7| 5| 7|            |
                             DAY ON TEST   | 3| 3| 3| 3| 3| 3| 9| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 9| 3| 8| 3| 3| 3| 8| 3|            |
                                           | 5| 5| 0| 5| 5| 5| 7| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 1| 5| 4| 5| 5| 5| 1| 5|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|      A     |
    50000                                  | 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1|      L     |
    PPM                                    | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 GENITAL SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
      Follicle, Cyst                       |             2                       2                                    |      4  1.8|
                                            __________________________________________________________________________|____________|
   Oviduct                                 |                                                                          |   1        |
      Cyst                                 |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hydrometra                           |                                              2  1        1               |      6  1.7|
      Thrombosis                           |                                                                          |      1  3.0|
      Endometrium, Cyst                    |          2                                                               |      4  1.8|
                                            __________________________________________________________________________|____________|
   Vagina                                  |                                                    +                     |   1        |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Atrophy                              |             1                                         1                  |      5  1.2|
      Hyperplasia                          |       2        1                                   2                     |      6  1.8|
      Myelofibrosis                        |                                                                          |      2  1.5|
                                            __________________________________________________________________________|____________|
   Lymph Node                              |                   +  +        +  +                 +     +               |   9        |
      Mediastinal, Hemorrhage              |                                                    2                     |      1  2.0|
      Mediastinal, Pigmentation            |                               3                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Degeneration, Cystic                 |             1              1           1                                 |      8  1.0|
      Hemorrhage                           |                                                                          |      1  1.0|
      Hyperplasia, Lymphoid                |                         2     2                                          |      5  1.8|
      Infiltration Cellular, Histiocyte    |       1        1                                                        1|      3  1.0|
      Pigmentation                         |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +|  48        |
      Degeneration, Cystic                 |                            1                                             |      1  1.0|
      Hemorrhage                           |          2                                                     2         |      2  2.0|
      Hyperplasia, Lymphoid                |                                     2                                    |      1  2.0|
      Infiltration Cellular, Histiocyte    | 2  1        1  1              1        1     2     2  1     1     1  1  1|     26  1.3|
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Congestion                           |                         3                                                |      1  3.0|
      Hematopoietic Cell Proliferation     | 1                                         1        3                    2|      6  1.7|
      Pigmentation                         |                               1     1                                    |      6  1.0|
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Hemorrhage                           |                                  1                                       |      1  1.0|
      Epithelial Cell, Hyperplasia         | 1  1           2           1  2     2  1  3     2     1                 1|     23  1.7|
      Thymocyte, Atrophy                   |       2  2     2     3     2  2  2     2  2  1  3           1        1  2|     23  2.0|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  37                                                               
NTP Experiment-Test: 05182-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          PHENOLPHTHALEIN                                      Date: 10/23/95  
Route: DOSED FEED                                                                                                 Time: 16:52:04  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 3| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 4| 7| 4| 7| 7| 7| 5| 7|            |
                             DAY ON TEST   | 3| 3| 3| 3| 3| 3| 9| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 9| 3| 8| 3| 3| 3| 8| 3|            |
                                           | 5| 5| 0| 5| 5| 5| 7| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 1| 5| 4| 5| 5| 5| 1| 5|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|      A     |
    50000                                  | 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1|      L     |
    PPM                                    | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 INTEGUMENTARY SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
      Galactocele                          |                2        1     1        1  2  1                 1     1  3|     17  1.5|
      Epithelium, Hyperplasia              |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Subcutaneous Tissue, Inflammation,   |                                                                          |            |
           Chronic, Focal                  |          1                                                               |      1  1.0|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Skeletal Muscle                         |                                                          +               |   2        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cerebrum, Hemorrhage, Focal          |                                                                      2   |      1  2.0|
      Meninges, Cerebrum, Hemorrhage       |                                                                      2   |      1  2.0|
                                            __________________________________________________________________________|____________|
   Peripheral Nerve                        |                                                          +               |   2        |
                                            __________________________________________________________________________|____________|
   Spinal Cord                             |                                                          +               |   2        |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hemorrhage                           |    1                                                        2           2|      4  1.5|
      Infiltration Cellular, Focal,        |                                                                          |            |
          Histiocyte                       |                                                                         1|      1  1.0|
      Interstitium, Inflammation, Chronic  | 1           1                    1                                       |      6  1.0|
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inflammation, Chronic                |                                                             1            |      4  1.3|
      Inflammation, Chronic Active         |                                                                          |      1  3.0|
      Nasolacrimal Duct, Inflammation,     |                                                                          |            |
           Acute                           |                   2                                                      |      2  2.0|
      Nasolacrimal Duct, Inflammation,     |                                                                          |            |
           Chronic Active                  |                                                                      2   |      1  2.0|
      Olfactory Epithelium, Cytoplasmic    |                                                                          |            |
          Alteration                       |                                                                      2   |      2  1.5|
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Inflammation, Chronic                |                                                                          |      1  1.0|
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Zymbal's Gland                          |                      +                                                   |   1        |
      Cyst                                 |                      2                                                   |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  38                                                               
NTP Experiment-Test: 05182-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          PHENOLPHTHALEIN                                      Date: 10/23/95  
Route: DOSED FEED                                                                                                 Time: 16:52:04  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 3| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 4| 7| 4| 7| 7| 7| 5| 7|            |
                             DAY ON TEST   | 3| 3| 3| 3| 3| 3| 9| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 9| 3| 8| 3| 3| 3| 8| 3|            |
                                           | 5| 5| 0| 5| 5| 5| 7| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 1| 5| 4| 5| 5| 5| 1| 5|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|      A     |
    50000                                  | 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1|      L     |
    PPM                                    | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 URINARY SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cyst                                 |                                                                          |      1  2.0|
      Ectopic Liver                        |                               X                                          |      1     |
      Mineralization, Focal                |                                  1                    1        1         |      3  1.0|
      Nephropathy, Chronic                 |                   1                                1                     |      2  1.0|
      Bilateral, Mineralization, Focal     |       1                             1                                1   |      5  1.0|
      Bilateral, Nephropathy, Chronic      | 2  2     2  1  2        1  1  2  1  2  1  1  1  1     2     1  1  2  1  2|     42  1.6|
      Bilateral, Renal Tubule,             |                                                                          |            |
          Accumulation, Hyaline Droplet    |                                                                          |      2  2.5|
      Bilateral, Renal Tubule, Pigmentation|    1           1     1                                                   |      8  1.3|
                                            __________________________________________________________________________|____________|
   Ureter                                  |                                                                          |   1        |
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  39                                                               
NTP Experiment-Test: 05182-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          PHENOLPHTHALEIN                                      Date: 10/23/95  
Route: DOSED FEED                                                                                                 Time: 16:52:04  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 2| 7| 5| 7| 7| 6| 3| 7| 7| 5| 7| 6| 7| 5| 6|             
                             DAY ON TEST   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 2| 6| 2| 2| 1| 3| 2| 2| 7| 2| 0| 2| 3| 1|             
                                           | 9| 0| 9| 9| 9| 9| 9| 9| 9| 9| 8| 9| 1| 9| 9| 7| 0| 4| 9| 7| 9| 8| 9| 4| 4|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    0 PPM                                  | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Parasite Metazoan                    |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Parasite Metazoan                    |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic Active         |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis, Focal                   | 2        3                             3                    2           2|             
      Basophilic Focus                     | X     X     X  X           X     X     1  X           X           X      |             
      Clear Cell Focus                     |                X                                                  X      |             
      Degeneration, Cystic, Focal          |                                                                          |             
      Eosinophilic Focus                   | X     X     X           X                             X                  |             
      Hematopoietic Cell Proliferation     |                                                          1               |             
      Hepatodiaphragmatic Nodule           |       X                       X                       X                  |             
      Mixed Cell Focus                     |                            X                                             |             
      Necrosis                             |                                                                          |             
      Bile Duct, Hyperplasia               | 2           2  1                          1           2  1               |             
      Centrilobular, Necrosis              |                                                                          |             
      Hepatocyte, Vacuolization Cytoplasmic|                                                                          |             
      Vein, Thrombosis                     |                                        3                                 |             
                                            __________________________________________________________________________|             
   Mesentery                               | +              +  +        +        +  +     +              +     +     +|             
      Fat, Necrosis                        | 3              3  3        3        4        4              2     3     2|             
                                            __________________________________________________________________________|             
   Oral Mucosa                             |                                                                          |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Infiltration Cellular, Focal,        |                                                                          |             
          Lymphocyte                       |                            1                                             |             
      Acinus, Atrophy, Diffuse             |    3                                                                     |             
      Acinus, Atrophy, Focal               | 2           2           2  2     2        2              1  2     3  2  2|             
      Acinus, Hyperplasia, Focal           |                                                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                                     3                                    |             
      Duct, Sublingual Gland, Hyperplasia, |                                                                          |             
           Focal                           |                2                                                         |             
      Sublingual Gland, Inflammation,      |                                                                          |             
          Chronic                          |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Edema                                |                                                                          |             
      Ulcer, Focal                         |                                     2                                    |             
      Epithelium, Hyperplasia              |                                     3              3                     |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  40                                                               
NTP Experiment-Test: 05182-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          PHENOLPHTHALEIN                                      Date: 10/23/95  
Route: DOSED FEED                                                                                                 Time: 16:52:04  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 2| 7| 5| 7| 7| 6| 3| 7| 7| 5| 7| 6| 7| 5| 6|             
                             DAY ON TEST   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 2| 6| 2| 2| 1| 3| 2| 2| 7| 2| 0| 2| 3| 1|             
                                           | 9| 0| 9| 9| 9| 9| 9| 9| 9| 9| 8| 9| 1| 9| 9| 7| 0| 4| 9| 7| 9| 8| 9| 4| 4|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    0 PPM                                  | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
                                           |                                                                          |             
      Erosion, Focal                       |    2                                            2  2                     |             
      Inflammation, Acute                  |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood Vessel                            | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cardiomyopathy                       | 2  3  1  2  1  3  1     4  2     2     2  1  2     2  2  1  2  1  2  2  1|             
      Atrium, Thrombosis                   |                                              3                           |             
      Atrium, Epicardium, Hyperplasia,     |                                                                          |             
           Focal                           |       2                                                                  |             
      Atrium, Epicardium, Pigmentation     |       2                                                                  |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Focal                   |                   1  2                                            2     1|             
      Hypertrophy, Focal                   |                1           2                                             |             
      Vacuolization Cytoplasmic, Focal     |                                                 1                    2   |             
                                            __________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Focal                   |    1                       3     3  2  2                          4  3   |             
      Infiltration Cellular, Lymphocyte    |                                                                          |             
      Bilateral, Hyperplasia, Focal        |                                                                          |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Focal                   |                                                       3                  |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  M  +  +  +  +  M  +  +  +  +  +  M  +  +  +  +  +|             
      Hyperplasia, Focal                   |                                                                          |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Pars Distalis, Angiectasis, Focal    |                         2                                                |             
      Pars Distalis, Cyst                  |             1                                                            |             
      Pars Distalis, Hyperplasia, Focal    |          1     2                 2     3              3  1               |             
      Pars Distalis, Hypertrophy, Focal    |       1                                                                  |             
      Pars Nervosa, Hyperplasia            |                                  2                                       |             
      Rathke's Cleft, Pigmentation         |                                                                          |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      C-Cell, Hyperplasia, Focal           | 2        1     4                 1     2  1  1                          2|             
      Follicle, Cyst                       | 2                                                                 1      |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Tissue NOS                              |                                                                          |             
      Mediastinum, Hemorrhage              |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Preputial Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Focal                   |                      3     4                                      3      |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  41                                                               
NTP Experiment-Test: 05182-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          PHENOLPHTHALEIN                                      Date: 10/23/95  
Route: DOSED FEED                                                                                                 Time: 16:52:04  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 2| 7| 5| 7| 7| 6| 3| 7| 7| 5| 7| 6| 7| 5| 6|             
                             DAY ON TEST   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 2| 6| 2| 2| 1| 3| 2| 2| 7| 2| 0| 2| 3| 1|             
                                           | 9| 0| 9| 9| 9| 9| 9| 9| 9| 9| 8| 9| 1| 9| 9| 7| 0| 4| 9| 7| 9| 8| 9| 4| 4|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    0 PPM                                  | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
      Inflammation, Chronic                |    2                 2                    1     1  1                     |             
      Inflammation, Chronic Active         |                                                                          |             
      Bilateral, Inflammation, Chronic     |       2  3  1  1  2     2  2           2     2        2  1        1  2  1|             
      Bilateral, Inflammation, Chronic     |                                                                          |             
          Active                           |                                  2  2                                    |             
                                            __________________________________________________________________________|             
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |    3  2  3  4  1        2  2     2  1        2                           |             
      Inflammation, Acute                  |                                                                1        1|             
      Inflammation, Chronic                | 2                                                                        |             
      Inflammation, Chronic Active         |                                        2  3                              |             
      Epithelium, Hyperplasia, Focal       |                                                                          |             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              | 2  4  3  2  2  3  3  2  3  3     1  4  3  2  3     3  2           3  2  3|             
      Inflammation, Acute                  |                                                                          |             
                                            __________________________________________________________________________|             
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Mineralization, Focal                |                                                    2                     |             
      Bilateral, Interstitial Cell,        |                                                                          |             
          Hyperplasia, Focal               |                                     1                                    |             
      Bilateral, Germinal Epithelium,      |                                                                          |             
          Atrophy                          |                   4              4  4              4                     |             
      Germinal Epithelium, Atrophy         |                                                                          |             
      Interstitial Cell, Hyperplasia, Focal|                                                                          |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                                           2                              |             
      Hyperplasia                          |                         1  2     2  2  2                 1  2        2  2|             
      Myelofibrosis                        |                2                                                         |             
      Necrosis                             |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node                              |    +     +                          +  +     +     +                    +|             
      Mediastinal, Hemorrhage              |                                                                         4|             
      Mediastinal, Pigmentation            |    1                                                                     |             
      Pancreatic, Hemorrhage               |                                                                          |             
      Renal, Hemorrhage                    |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Degeneration, Cystic                 |       1     3           3        3                          2     2      |             
      Hemorrhage                           |                                                                          |             
      Hyperplasia, Lymphoid                |       2                    1                                2        2   |             
      Infiltration Cellular, Histiocyte    |                                                       1                  |             
      Pigmentation                         |                1                                                         |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |          2                                                               |             
      Hyperplasia, Lymphoid                |                                                                          |             
      Infiltration Cellular, Histiocyte    | 1     1  2  1  3  1  2  2  1     2     2  2           2  1  1  1  1  2  2|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  42                                                               
NTP Experiment-Test: 05182-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          PHENOLPHTHALEIN                                      Date: 10/23/95  
Route: DOSED FEED                                                                                                 Time: 16:52:04  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 2| 7| 5| 7| 7| 6| 3| 7| 7| 5| 7| 6| 7| 5| 6|             
                             DAY ON TEST   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 2| 6| 2| 2| 1| 3| 2| 2| 7| 2| 0| 2| 3| 1|             
                                           | 9| 0| 9| 9| 9| 9| 9| 9| 9| 9| 8| 9| 1| 9| 9| 7| 0| 4| 9| 7| 9| 8| 9| 4| 4|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    0 PPM                                  | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Congestion                           |                                                                          |             
      Fibrosis                             |                                                                          |             
      Hematopoietic Cell Proliferation     |                                           1              2           2   |             
      Capsule, Degeneration, Cystic        |                            2                                             |             
      Lymphoid Follicle, Atrophy           |                                                                          |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |                                                                          |             
      Epithelial Cell, Hyperplasia         | 1  2  2        2     2  2  2     1  2  2  2           2  2  1     3  1  1|             
      Thymocyte, Atrophy                   | 2  4        2  3  3        3  4     4  2     4  4  4  2     2     1  3  4|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +|             
      Galactocele                          |                                           2        1                     |             
      Pigmentation                         |                                     2                                    |             
      Epithelium, Hyperplasia              |                                                                          |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrosis, Focal                      |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Femur, Hyperostosis                  |                                     2                                    |             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |                                                 +                        |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hydrocephalus                        |                                                                      1   |             
      Hippocampus, Cerebrum, Necrosis,     |                                                                          |             
           Focal                           |                                     2                                    |             
                                            __________________________________________________________________________|             
   Peripheral Nerve                        |                                                 +                        |             
                                            __________________________________________________________________________|             
   Spinal Cord                             |                                                 +                        |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Congestion                           |                                                                          |             
      Foreign Body                         |                                                                          |             
      Hemorrhage                           |                                                             3            |             
      Infiltration Cellular, Focal,        |                                                                          |             
          Histiocyte                       |                                                                          |             
      Inflammation, Chronic Active         |                                                                          |             
      Alveolar Epithelium, Hyperplasia,    |                                                                          |             
           Focal                           | 2                                                                        |             
      Interstitium, Inflammation, Chronic  |       1                                                                  |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  43                                                               
NTP Experiment-Test: 05182-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          PHENOLPHTHALEIN                                      Date: 10/23/95  
Route: DOSED FEED                                                                                                 Time: 16:52:04  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 2| 7| 5| 7| 7| 6| 3| 7| 7| 5| 7| 6| 7| 5| 6|             
                             DAY ON TEST   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 2| 6| 2| 2| 1| 3| 2| 2| 7| 2| 0| 2| 3| 1|             
                                           | 9| 0| 9| 9| 9| 9| 9| 9| 9| 9| 8| 9| 1| 9| 9| 7| 0| 4| 9| 7| 9| 8| 9| 4| 4|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    0 PPM                                  | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
      Inflammation, Acute                  |                                                                          |             
      Inflammation, Chronic                |                                                       2     2            |             
      Inflammation, Chronic Active         |    3  3     3           3        3                             3  2     3|             
      Metaplasia, Squamous                 |                         2                                                |             
      Nasolacrimal Duct, Inflammation,     |                                                                          |             
           Chronic Active                  |                                                                          |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Glands, Cyst, Focal                  |                                                                         2|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ear                                     |                                                                          |             
                                            __________________________________________________________________________|             
   Zymbal's Gland                          |                                                          +               |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                            1                                             |             
      Mineralization, Focal                |                               1                                          |             
      Nephropathy, Chronic                 |          2  2                                                            |             
      Bilateral, Nephropathy, Chronic      | 2  2  3        1  2  2  3  2  1  2  2  2  2  2  1  2  2  2  2  1  2  1  2|             
      Bilateral, Pelvis, Transitional      |                                                                          |             
          Epithelium, Hyperplasia          |                                                                          |             
      Bilateral, Renal Tubule, Pigmentation|                                     3        3     3        2        1  3|             
      Pelvis, Transitional Epithelium,     |                                                                          |             
           Hyperplasia                     |                         2        1                 2                     |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |                                                                          |             
      Inflammation, Acute                  |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  44                                                               
NTP Experiment-Test: 05182-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          PHENOLPHTHALEIN                                      Date: 10/23/95  
Route: DOSED FEED                                                                                                 Time: 16:52:04  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 5| 6| 7| 6| 4| 4| 7| 5| 6| 5| 7| 5| 6| 7| 6| 7| 4| 5| 7| 7| 7| 7| 6| 4|            |
                             DAY ON TEST   | 2| 2| 4| 2| 1| 8| 9| 2| 5| 7| 9| 2| 0| 4| 1| 8| 2| 9| 7| 0| 2| 0| 2| 0| 0|            |
                                           | 9| 9| 9| 9| 5| 6| 8| 9| 3| 1| 8| 9| 6| 3| 5| 5| 9| 0| 1| 8| 9| 4| 7| 1| 7|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      A     |
    0 PPM                                  | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +|  48        |
      Parasite Metazoan                    |                                                                         X|      1     |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  A  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Parasite Metazoan                    |                                  X                                       |      1     |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  A  +  +  +  A  +  A  +  +  A  A  +  +  A  +  +|  44        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +|  47        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  A  +  +  +  +  A  A  +  +  +  +  +  +  +  +  +|  47        |
      Inflammation, Chronic Active         |                      2                                                   |      1  2.0|
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  A  +  +  A  A  +  +  A  +  +|  44        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Angiectasis, Focal                   | 2     1                                                                  |      7  2.1|
      Basophilic Focus                     | X  X     X                       X              X     X     X            |     17  1.0|
      Clear Cell Focus                     |                                                                          |      2     |
      Degeneration, Cystic, Focal          |    2                             2                       2  2            |      4  2.0|
      Eosinophilic Focus                   | X  X                 X                                                   |      8     |
      Hematopoietic Cell Proliferation     |                                           2                              |      2  1.5|
      Hepatodiaphragmatic Nodule           |                                                    X                     |      4     |
      Mixed Cell Focus                     |                      X           X                          X            |      4     |
      Necrosis                             |             4                                                            |      1  4.0|
      Bile Duct, Hyperplasia               |    2  1  1                                                        3      |     10  1.6|
      Centrilobular, Necrosis              |                                              4                    3      |      2  3.5|
      Hepatocyte, Vacuolization Cytoplasmic|                                     2        2                    2      |      3  2.0|
      Vein, Thrombosis                     |                                                                   4      |      2  3.5|
                                            __________________________________________________________________________|____________|
   Mesentery                               | +  +  +  +     +           +  +  +                       +  M           +|  20        |
      Fat, Necrosis                        | 3  3  3  2     3           3  3  2                       3              2|     19  2.8|
                                            __________________________________________________________________________|____________|
   Oral Mucosa                             |                                                                      +   |   1        |
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Infiltration Cellular, Focal,        |                                                                          |            |
          Lymphocyte                       |                                                                          |      1  1.0|
      Acinus, Atrophy, Diffuse             |                                                                          |      1  3.0|
      Acinus, Atrophy, Focal               | 2     1  1           2           4     2  1        3  2  1        2      |     22  2.0|
      Acinus, Hyperplasia, Focal           |                                  1                                       |      1  1.0|
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Atrophy                              |                                                                          |      1  3.0|
      Duct, Sublingual Gland, Hyperplasia, |                                                                          |            |
           Focal                           |                                                                          |      1  2.0|
      Sublingual Gland, Inflammation,      |                                                                          |            |
          Chronic                          |                                     2                                    |      1  2.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  45                                                               
NTP Experiment-Test: 05182-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          PHENOLPHTHALEIN                                      Date: 10/23/95  
Route: DOSED FEED                                                                                                 Time: 16:52:04  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 5| 6| 7| 6| 4| 4| 7| 5| 6| 5| 7| 5| 6| 7| 6| 7| 4| 5| 7| 7| 7| 7| 6| 4|            |
                             DAY ON TEST   | 2| 2| 4| 2| 1| 8| 9| 2| 5| 7| 9| 2| 0| 4| 1| 8| 2| 9| 7| 0| 2| 0| 2| 0| 0|            |
                                           | 9| 9| 9| 9| 5| 6| 8| 9| 3| 1| 8| 9| 6| 3| 5| 5| 9| 0| 1| 8| 9| 4| 7| 1| 7|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      A     |
    0 PPM                                  | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Edema                                |                               2                                          |      1  2.0|
      Ulcer, Focal                         |                         2                                                |      2  2.0|
      Epithelium, Hyperplasia              |                                     2                                2   |      4  2.5|
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Erosion, Focal                       |                2  2     3                                3        2      |      8  2.3|
      Inflammation, Acute                  |                                           1                              |      1  1.0|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood Vessel                            | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cardiomyopathy                       | 2  3  1  1  3        3     2     2     2  2  1  2     2  2  2     2  3  2|     39  1.9|
      Atrium, Thrombosis                   |                                        4                          4      |      3  3.7|
      Atrium, Epicardium, Hyperplasia,     |                                                                          |            |
           Focal                           |                                                                          |      1  2.0|
      Atrium, Epicardium, Pigmentation     |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia, Focal                   |                                                                          |      4  1.5|
      Hypertrophy, Focal                   |                                                                          |      2  1.5|
      Vacuolization Cytoplasmic, Focal     |             2                          2  3     1                        |      6  1.8|
                                            __________________________________________________________________________|____________|
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia, Focal                   | 2           2           2        1                                2      |     12  2.3|
      Infiltration Cellular, Lymphocyte    |                                           1                              |      1  1.0|
      Bilateral, Hyperplasia, Focal        |                               2                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia, Focal                   |                                                             2            |      2  2.5|
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  M  +  +  +  +  +  +  M  +  M  +  +  +  +  M  +  +  M  +  M  +  +  +  +|  41        |
      Hyperplasia, Focal                   |                                                                2         |      1  2.0|
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Pars Distalis, Angiectasis, Focal    |                                                                          |      1  2.0|
      Pars Distalis, Cyst                  |                                                                          |      1  1.0|
      Pars Distalis, Hyperplasia, Focal    |          3              1                             1                  |      9  1.9|
      Pars Distalis, Hypertrophy, Focal    |                                                                          |      1  1.0|
      Pars Nervosa, Hyperplasia            |                                                                          |      1  2.0|
      Rathke's Cleft, Pigmentation         |                                                             3            |      1  3.0|
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      C-Cell, Hyperplasia, Focal           |                               2     3              1           1     1   |     13  1.7|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  46                                                               
NTP Experiment-Test: 05182-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          PHENOLPHTHALEIN                                      Date: 10/23/95  
Route: DOSED FEED                                                                                                 Time: 16:52:04  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 5| 6| 7| 6| 4| 4| 7| 5| 6| 5| 7| 5| 6| 7| 6| 7| 4| 5| 7| 7| 7| 7| 6| 4|            |
                             DAY ON TEST   | 2| 2| 4| 2| 1| 8| 9| 2| 5| 7| 9| 2| 0| 4| 1| 8| 2| 9| 7| 0| 2| 0| 2| 0| 0|            |
                                           | 9| 9| 9| 9| 5| 6| 8| 9| 3| 1| 8| 9| 6| 3| 5| 5| 9| 0| 1| 8| 9| 4| 7| 1| 7|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      A     |
    0 PPM                                  | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 __________________________________________________________________________________________________________________________________ 
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
                                           |                                                                          |            |
      Follicle, Cyst                       |                      1                                                   |      3  1.3|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Tissue NOS                              |    +                                                                     |   1        |
      Mediastinum, Hemorrhage              |    4                                                                     |      1  4.0|
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Preputial Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia, Focal                   |                                                                          |      3  3.3|
      Inflammation, Chronic                |                1        1     2        1  2     1  2  2     1            |     14  1.4|
      Inflammation, Chronic Active         |                   1                                                      |      1  1.0|
      Bilateral, Inflammation, Chronic     | 2           1        1           2                                3  2  1|     21  1.7|
      Bilateral, Inflammation, Chronic     |                                                                          |            |
          Active                           |       3                                      3           3     2         |      6  2.5|
                                            __________________________________________________________________________|____________|
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Atrophy                              |                               1     1  2     1                           |     14  1.9|
      Inflammation, Acute                  |       3           2                       3                       2      |      6  2.0|
      Inflammation, Chronic                |                                                                          |      1  2.0|
      Inflammation, Chronic Active         |                                                                3         |      3  2.7|
      Epithelium, Hyperplasia, Focal       | 2                                                                        |      1  2.0|
                                            __________________________________________________________________________|____________|
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Atrophy                              | 1        2           2     3  2  2     2     3  3  2     3        2  3   |     33  2.5|
      Inflammation, Acute                  |                                           2                              |      1  2.0|
                                            __________________________________________________________________________|____________|
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Mineralization, Focal                |                                                                          |      1  2.0|
      Bilateral, Interstitial Cell,        |                                                                          |            |
          Hyperplasia, Focal               |                                                                         4|      2  2.5|
      Bilateral, Germinal Epithelium,      |                                                                          |            |
          Atrophy                          |                                                                          |      4  4.0|
      Germinal Epithelium, Atrophy         |                                           4                       4      |      2  4.0|
      Interstitial Cell, Hyperplasia, Focal|       1                                                              2   |      2  1.5|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  A  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Atrophy                              |                                                                          |      1  2.0|
      Hyperplasia                          | 2                    2                    2              2        2  1   |     15  1.8|
      Myelofibrosis                        |                                                                          |      1  2.0|
      Necrosis                             |                                              2                           |      1  2.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  47                                                               
NTP Experiment-Test: 05182-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          PHENOLPHTHALEIN                                      Date: 10/23/95  
Route: DOSED FEED                                                                                                 Time: 16:52:04  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 5| 6| 7| 6| 4| 4| 7| 5| 6| 5| 7| 5| 6| 7| 6| 7| 4| 5| 7| 7| 7| 7| 6| 4|            |
                             DAY ON TEST   | 2| 2| 4| 2| 1| 8| 9| 2| 5| 7| 9| 2| 0| 4| 1| 8| 2| 9| 7| 0| 2| 0| 2| 0| 0|            |
                                           | 9| 9| 9| 9| 5| 6| 8| 9| 3| 1| 8| 9| 6| 3| 5| 5| 9| 0| 1| 8| 9| 4| 7| 1| 7|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      A     |
    0 PPM                                  | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lymph Node                              |             +  +  +        +  +        +  +        +           +  +      |  17        |
      Mediastinal, Hemorrhage              |                                                                          |      1  4.0|
      Mediastinal, Pigmentation            |                                                                          |      1  1.0|
      Pancreatic, Hemorrhage               |             2                                                            |      1  2.0|
      Renal, Hemorrhage                    |                                           2                       3      |      2  2.5|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Degeneration, Cystic                 |          2                                2     1                        |      9  2.1|
      Hemorrhage                           |                                     1                                    |      1  1.0|
      Hyperplasia, Lymphoid                |          2                                2     2                        |      7  1.9|
      Infiltration Cellular, Histiocyte    |                      2                                                   |      2  1.5|
      Pigmentation                         |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hemorrhage                           |                                     2     2  3                           |      4  2.3|
      Hyperplasia, Lymphoid                |                                                                         2|      1  2.0|
      Infiltration Cellular, Histiocyte    | 2  1  2  2  1        2     2     2              1     2  2  2     1  1   |     33  1.6|
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Congestion                           |                                                                   2      |      1  2.0|
      Fibrosis                             |             2                    2        2                              |      3  2.0|
      Hematopoietic Cell Proliferation     | 1                                         3           1                  |      6  1.7|
      Capsule, Degeneration, Cystic        |                                                                          |      1  2.0|
      Lymphoid Follicle, Atrophy           |                                              4                    3      |      2  3.5|
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hemorrhage                           |                   3                                   2                 2|      3  2.3|
      Epithelial Cell, Hyperplasia         | 2                    2        1           2              1  1     2      |     24  1.7|
      Thymocyte, Atrophy                   | 2  3  3     4  4     3     2  2  2  3  4  3  3  1