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TDMS Study 05184-05 Pathology Tables

NTP Experiment-Test: 05184-05  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                           GLUTARALDEHYDE                                      Date: 09/14/98
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 08:27:39

                                                         2 YEAR CHRONIC




       Facility:  Battelle Northwest

       Chemical CAS #:  111-30-8

       Lock Date:  07/28/97

       Cage Range:  All

       Reasons For Removal:    All

       Removal Date Range:     All

       Treatment Groups:       Include All


































a  Number of animals examined microscopically at site and number of animals with lesion

                                                              Page   1



NTP Experiment-Test: 05184-05  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                           GLUTARALDEHYDE                                      Date: 09/14/98  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 08:27:39  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS FEMALE                   CONTROL      250 PPB      500 PPB      750 PPB                                   
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
DISPOSITION SUMMARY                                                                                                                 

  Animals Initially in Study                          50           50           50           50                                     
  Early Deaths                                                                                                                      
    Moribund Sacrifice                                22           17           32           34                                     
    Natural Death                                      2            2            3            2                                     
  Survivors                                                                                                                         
    Terminal Sacrifice                                26           31           15           14                                     

  Animals Examined Microscopically                    50           50           50           50                                     
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Esophagus                                          (50)         (50)         (50)         (49)                                   
   Liver                                              (50)         (50)         (50)         (50)                                   
      Rhabdomyosarcoma, Metastatic, Skeletal Muscle                              1 (2%)                                             
   Mesentery                                          (10)         (9)          (7)          (3)                                    
      Sarcoma                                          2 (20%)                                                                      
   Oral Mucosa                                        (1)                                    (1)                                    
      Gingival, Squamous Cell Carcinoma                1 (100%)                                                                     
      Lingual, Squamous Cell Carcinoma                                                        1 (100%)                              
   Pancreas                                           (50)         (50)         (50)         (50)                                   
   Stomach, Glandular                                 (49)         (49)         (50)         (50)                                   
   Tongue                                             (1)          (1)                                                              
      Squamous Cell Papilloma                          1 (100%)                                                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Heart                                              (50)         (50)         (50)         (50)                                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Cortex                                     (50)         (50)         (50)         (49)                                   
   Adrenal Medulla                                    (50)         (50)         (50)         (49)                                   
      Pheochromocytoma Malignant                                    1 (2%)                    1 (2%)                                
      Pheochromocytoma Benign                                                    1 (2%)                                             
   Islets, Pancreatic                                 (49)         (50)         (50)         (50)                                   
      Adenoma                                                       1 (2%)                                                          
      Carcinoma                                                                  1 (2%)                                             
   Pituitary Gland                                    (50)         (50)         (50)         (49)                                   
      Pars Distalis, Adenoma                          37 (74%)     37 (74%)     27 (54%)     24 (49%)                               
   Thyroid Gland                                      (50)         (50)         (49)         (49)                                   
      C-Cell, Adenoma                                  2 (4%)       1 (2%)       2 (4%)                                             
      C-Cell, Carcinoma                                             2 (4%)                                                          
NTP Experiment-Test: 05184-05  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                           GLUTARALDEHYDE                                      Date: 09/14/98  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 08:27:39  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS FEMALE                   CONTROL      250 PPB      500 PPB      750 PPB                                   
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ENDOCRINE SYSTEM - cont                                                                                                             
      Follicular Cell, Adenoma                                                                2 (4%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Clitoral Gland                                     (49)         (50)         (50)         (50)                                   
      Adenoma                                          3 (6%)       3 (6%)       1 (2%)                                             
      Carcinoma                                        3 (6%)       2 (4%)       1 (2%)       1 (2%)                                
   Ovary                                              (50)         (50)         (50)         (49)                                   
      Granulosa Cell Tumor Malignant                                                          1 (2%)                                
      Granulosa-Theca Tumor Malignant                  1 (2%)                    1 (2%)                                             
   Uterus                                             (50)         (50)         (50)         (50)                                   
      Deciduoma Benign                                                           1 (2%)                                             
      Polyp Stromal                                    8 (16%)     10 (20%)      8 (16%)      3 (6%)                                
      Sarcoma Stromal                                                            1 (2%)                                             
      Serosa, Leiomyoma                                                                       1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (50)         (50)         (50)         (50)                                   
   Lymph Node                                         (2)          (3)          (3)          (2)                                    
      Iliac, Sarcoma, Metastatic, Skin                 1 (50%)                                                                      
   Lymph Node, Bronchial                              (46)         (46)         (48)         (42)                                   
      Sarcoma, Metastatic, Skin                        1 (2%)                                                                       
   Lymph Node, Mandibular                             (48)         (49)         (48)         (46)                                   
   Lymph Node, Mesenteric                             (50)         (50)         (50)         (50)                                   
   Lymph Node, Mediastinal                            (50)         (50)         (50)         (49)                                   
      Sarcoma, Metastatic, Skin                        1 (2%)                                                                       
   Spleen                                             (50)         (50)         (50)         (50)                                   
   Thymus                                             (50)         (50)         (50)         (49)                                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Mammary Gland                                      (50)         (50)         (50)         (50)                                   
      Carcinoma                                        5 (10%)      8 (16%)      3 (6%)       1 (2%)                                
      Fibroadenoma                                    15 (30%)     18 (36%)     15 (30%)      9 (18%)                               
      Fibroadenoma, Multiple                           9 (18%)      5 (10%)      3 (6%)       1 (2%)                                
   Skin                                               (50)         (50)         (50)         (50)                                   
      Fibroma                                                                    1 (2%)                                             
      Fibrosarcoma                                     1 (2%)                                                                       
NTP Experiment-Test: 05184-05  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                           GLUTARALDEHYDE                                      Date: 09/14/98  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 08:27:39  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS FEMALE                   CONTROL      250 PPB      500 PPB      750 PPB                                   
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
INTEGUMENTARY SYSTEM - cont                                                                                                         
      Keratoacanthoma                                  2 (4%)                                                                       
      Schwannoma Benign                                             1 (2%)                                                          
      Squamous Cell Papilloma                                       1 (2%)       1 (2%)                                             
      Lip, Squamous Cell Carcinoma                     1 (2%)                                                                       
      Subcutaneous Tissue, Fibrosarcoma                             1 (2%)                                                          
      Subcutaneous Tissue, Sarcoma                     1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Bone                                               (50)         (50)         (50)         (50)                                   
      Squamous Cell Carcinoma, Metastatic, Oral                                                                                     
          Mucosa                                                                              1 (2%)                                
      Mandible, Squamous Cell Carcinoma,                                                                                            
          Metastatic, Skin                             1 (2%)                                                                       
      Mandible, Squamous Cell Carcinoma,                                                                                            
          Metastatic, Oral Mucosa                      1 (2%)                                                                       
   Skeletal Muscle                                    (1)                       (1)                                                 
      Rhabdomyosarcoma                                                           1 (100%)                                           
      Squamous Cell Carcinoma, Metastatic, Oral                                                                                     
          Mucosa                                       1 (100%)                                                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (50)         (50)         (50)         (49)                                   
      Alveolar/Bronchiolar Adenoma                                               1 (2%)                                             
      Sarcoma, Metastatic, Mesentery                   1 (2%)                                                                       
      Sarcoma, Metastatic, Skin                        1 (2%)                                                                       
      Squamous Cell Carcinoma, Metastatic, Oral                                                                                     
          Mucosa                                       1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Zymbal's Gland                                                               (1)                                                 
      Carcinoma                                                                  1 (100%)                                           
____________________________________________________________________________________________________________________________________
                                                                                                                                    
NTP Experiment-Test: 05184-05  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                           GLUTARALDEHYDE                                      Date: 09/14/98  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 08:27:39  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS FEMALE                   CONTROL      250 PPB      500 PPB      750 PPB                                   
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (49)         (50)         (50)         (50)                                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SYSTEMIC LESIONS                                                                                                                   

   Multiple Organs                                   *(50)        *(50)        *(50)        *(50)                                   
      Leukemia Mononuclear                            18 (36%)     20 (40%)     25 (50%)     12 (24%)                               
____________________________________________________________________________________________________________________________________
     *   Number of animals with any tissue examined microscopically                                                                 


                                                             Page   5                                                               
NTP Experiment-Test: 05184-05  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                           GLUTARALDEHYDE                                      Date: 09/14/98  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 08:27:39  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS FEMALE                   CONTROL      250 PPB      500 PPB      750 PPB                                   
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
TUMOR SUMMARY                                                                                                                       
                                                                                                                                    
   Total Animals with Primary Neoplasms (b)            49          46          49          36                                       
     Total Primary Neoplasms                          110         111          95          57                                       
                                                                                                                                    
   Total Animals with Benign Neoplasms                 42          43          40          31                                       
     Total Benign Neoplasms                            77          77          61          40                                       
                                                                                                                                    
   Total Animals with Malignant Neoplasms              27          26          29          16                                       
     Total Malignant Neoplasms                         33          34          34          17                                       
                                                                                                                                    
   Total Animals with Metastatic Neoplasms              4                       1           1                                       
     Total Metastatic Neoplasm                          9                       1           1                                       
                                                                                                                                    
   Total Animals with Malignant Neoplasms                                                                                           
   Uncertain Primary Site                                                                                                           
                                                                                                                                    
   Total Animals with Neoplasms Uncertain-                                                                                          
   Benign or Malignant                                                                                                              
     Total Uncertain Neoplasms                                                                                                      
                                                                                                                                    

____________________________________________________________________________________________________________________________________
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Primary tumors: all tumors except metastatic tumors                                                                              
NTP Experiment-Test: 05184-05  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                           GLUTARALDEHYDE                                      Date: 09/14/98  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 08:27:39  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     CONTROL      250 PPB      500 PPB      750 PPB                                   
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
DISPOSITION SUMMARY                                                                                                                 

  Animals Initially in Study                          50           50           50           50                                     
  Early Deaths                                                                                                                      
    Moribund Sacrifice                                33           30           32           37                                     
    Natural Death                                      5            6            9            7                                     
  Survivors                                                                                                                         
    Terminal Sacrifice                                11           14            9            6                                     
    Natural Death                                      1                                                                            

  Animals Examined Microscopically                    50           50           50           50                                     
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Intestine Large, Colon                             (49)         (48)         (48)         (45)                                   
      Carcinoma, Metastatic, Pancreas                  1 (2%)                                                                       
   Intestine Large, Cecum                             (47)         (46)         (48)         (45)                                   
   Intestine Small, Jejunum                           (47)         (46)         (43)         (44)                                   
      Carcinoma                                        1 (2%)                                                                       
      Carcinoma, Metastatic, Pancreas                  1 (2%)                                                                       
   Liver                                              (50)         (50)         (50)         (50)                                   
      Hepatocellular Carcinoma                                      1 (2%)                                                          
   Mesentery                                          (10)         (7)          (6)          (7)                                    
      Carcinoma, Metastatic, Pancreas                  1 (10%)                                                                      
   Oral Mucosa                                                                  (1)          (1)                                    
      Squamous Cell Carcinoma                                                    1 (100%)                                           
      Pharyngeal, Squamous Cell Papilloma                                                     1 (100%)                              
   Pancreas                                           (50)         (49)         (50)         (48)                                   
      Carcinoma                                        1 (2%)                                                                       
   Stomach, Forestomach                               (49)         (49)         (50)         (48)                                   
      Squamous Cell Papilloma                                                    1 (2%)                                             
   Tongue                                             (1)          (2)                       (1)                                    
      Squamous Cell Papilloma                                       1 (50%)                   1 (100%)                              
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Heart                                              (50)         (50)         (50)         (50)                                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Cortex                                     (50)         (50)         (50)         (49)                                   
      Adenoma                                                                    1 (2%)                                             
   Adrenal Medulla                                    (50)         (50)         (50)         (49)                                   
      Pheochromocytoma Malignant                       1 (2%)       2 (4%)       2 (4%)       1 (2%)                                
NTP Experiment-Test: 05184-05  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                           GLUTARALDEHYDE                                      Date: 09/14/98  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 08:27:39  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     CONTROL      250 PPB      500 PPB      750 PPB                                   
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ENDOCRINE SYSTEM - cont                                                                                                             
      Pheochromocytoma Complex                         1 (2%)                    1 (2%)                                             
      Pheochromocytoma Benign                          2 (4%)       4 (8%)       6 (12%)      2 (4%)                                
      Bilateral, Pheochromocytoma Malignant                         1 (2%)                                                          
      Bilateral, Pheochromocytoma Benign               2 (4%)       1 (2%)                                                          
   Islets, Pancreatic                                 (50)         (49)         (50)         (48)                                   
      Adenoma                                          1 (2%)       3 (6%)       1 (2%)       1 (2%)                                
      Carcinoma                                        4 (8%)       1 (2%)       1 (2%)       1 (2%)                                
   Pituitary Gland                                    (50)         (49)         (50)         (50)                                   
      Pars Distalis, Adenoma                          32 (64%)     26 (53%)     26 (52%)     20 (40%)                               
      Pars Intermedia, Adenoma                                                                1 (2%)                                
   Thyroid Gland                                      (50)         (50)         (50)         (50)                                   
      C-Cell, Adenoma                                  1 (2%)       4 (8%)       2 (4%)       2 (4%)                                
      C-Cell, Carcinoma                                             1 (2%)                                                          
      Follicular Cell, Adenoma                         1 (2%)                                                                       
      Follicular Cell, Carcinoma                                    1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   Tissue NOS                                         (1)          (2)                                                              
      Organ of Zuckerkandl, Paraganglioma Malignant                 1 (50%)                                                         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Epididymis                                         (50)         (50)         (50)         (50)                                   
      Carcinoma, Metastatic, Pancreas                  1 (2%)                                                                       
   Preputial Gland                                    (50)         (50)         (50)         (50)                                   
      Adenoma                                          1 (2%)       2 (4%)                                                          
      Carcinoma                                                     2 (4%)       1 (2%)       2 (4%)                                
   Seminal Vesicle                                    (50)         (50)         (50)         (49)                                   
      Carcinoma, Metastatic, Pancreas                  1 (2%)                                                                       
   Testes                                             (50)         (50)         (50)         (50)                                   
      Bilateral, Interstitial Cell, Adenoma           26 (52%)     32 (64%)     27 (54%)     25 (50%)                               
      Interstitial Cell, Adenoma                      10 (20%)     12 (24%)     13 (26%)      6 (12%)                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (50)         (50)         (50)         (50)                                   
   Lymph Node                                         (1)          (4)          (1)          (4)                                    
   Lymph Node, Bronchial                              (39)         (42)         (40)         (42)                                   
   Lymph Node, Mandibular                             (47)         (48)         (49)         (49)                                   
   Lymph Node, Mesenteric                             (50)         (49)         (50)         (50)                                   
      Carcinoma, Metastatic, Pancreas                  1 (2%)                                                                       
   Lymph Node, Mediastinal                            (47)         (50)         (50)         (50)                                   
   Spleen                                             (50)         (50)         (50)         (50)                                   
NTP Experiment-Test: 05184-05  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                           GLUTARALDEHYDE                                      Date: 09/14/98  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 08:27:39  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     CONTROL      250 PPB      500 PPB      750 PPB                                   
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
HEMATOPOIETIC SYSTEM - cont                                                                                                         
   Thymus                                             (50)         (50)         (50)         (50)                                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Mammary Gland                                      (49)         (50)         (50)         (50)                                   
      Adenoma                                                                                 1 (2%)                                
      Carcinoma                                        1 (2%)       2 (4%)                                                          
      Fibroadenoma                                     1 (2%)       3 (6%)       2 (4%)       2 (4%)                                
   Skin                                               (50)         (50)         (50)         (50)                                   
      Basal Cell Adenoma                                            1 (2%)                                                          
      Fibroma                                                       2 (4%)                                                          
      Keratoacanthoma                                  1 (2%)       5 (10%)      2 (4%)       1 (2%)                                
      Squamous Cell Carcinoma                                                                 1 (2%)                                
      Squamous Cell Papilloma                                                    1 (2%)                                             
      Trichoepithelioma                                1 (2%)                                                                       
      Lip, Basal Cell Adenoma                                                    1 (2%)                                             
      Pinna, Squamous Cell Papilloma                                                          1 (2%)                                
      Sebaceous Gland, Adenoma                         1 (2%)                                                                       
      Sebaceous Gland, Carcinoma                                    1 (2%)                                                          
      Subcutaneous Tissue, Fibroma                     4 (8%)       1 (2%)                    1 (2%)                                
      Subcutaneous Tissue, Fibrosarcoma                             2 (4%)                                                          
      Subcutaneous Tissue, Lipoma                                                1 (2%)                                             
      Subcutaneous Tissue, Sarcoma                                               1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Bone                                               (50)         (50)         (50)         (50)                                   
      Mandible, Osteosarcoma                           1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (50)         (50)         (50)         (50)                                   
      Alveolar/Bronchiolar Adenoma                                  1 (2%)                    2 (4%)                                
      Alveolar/Bronchiolar Adenoma, Multiple                                     1 (2%)                                             
      Alveolar/Bronchiolar Carcinoma                                                          1 (2%)                                
      Carcinoma, Metastatic, Pancreas                  1 (2%)                                                                       
      Carcinoma, Metastatic, Skin                                   1 (2%)                                                          
      Fibrosarcoma, Metastatic, Skin                                1 (2%)                                                          
      Osteosarcoma, Metastatic, Bone                   1 (2%)                                                                       
NTP Experiment-Test: 05184-05  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                           GLUTARALDEHYDE                                      Date: 09/14/98  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 08:27:39  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     CONTROL      250 PPB      500 PPB      750 PPB                                   
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
RESPIRATORY SYSTEM - cont                                                                                                           
      Sarcoma Stromal, Metastatic, Kidney                                        1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Zymbal's Gland                                     (1)          (3)          (1)                                                 
      Adenoma                                                       1 (33%)                                                         
      Carcinoma                                        1 (100%)     2 (67%)      1 (100%)                                           
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (50)         (50)         (50)         (50)                                   
      Stromal Nephroma                                                           1 (2%)                                             
      Renal Tubule, Adenoma                                         3 (6%)                    1 (2%)                                
      Renal Tubule, Carcinoma                                                                 1 (2%)                                
   Urinary Bladder                                    (50)         (49)         (50)         (48)                                   
      Papilloma                                                                  1 (2%)                                             
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SYSTEMIC LESIONS                                                                                                                   

   Multiple Organs                                   *(50)        *(50)        *(50)        *(50)                                   
      Leukemia Mononuclear                            21 (42%)     24 (48%)     25 (50%)     16 (32%)                               
      Mesothelioma Malignant                           2 (4%)       1 (2%)                    1 (2%)                                
____________________________________________________________________________________________________________________________________
     *   Number of animals with any tissue examined microscopically                                                                 


                                                             Page  10                                                               
NTP Experiment-Test: 05184-05  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                           GLUTARALDEHYDE                                      Date: 09/14/98  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 08:27:39  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     CONTROL      250 PPB      500 PPB      750 PPB                                   
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
TUMOR SUMMARY                                                                                                                       
                                                                                                                                    
   Total Animals with Primary Neoplasms (b)            49          50          50          38                                       
     Total Primary Neoplasms                          118         144         120          92                                       
                                                                                                                                    
   Total Animals with Benign Neoplasms                 48          48          50          38                                       
     Total Benign Neoplasms                            84         103          86          68                                       
                                                                                                                                    
   Total Animals with Malignant Neoplasms              28          33          31          19                                       
     Total Malignant Neoplasms                         34          41          34          24                                       
                                                                                                                                    
   Total Animals with Metastatic Neoplasms              3           2           1           1                                       
     Total Metastatic Neoplasm                         10           2           1           3                                       
                                                                                                                                    
   Total Animals with Malignant Neoplasms                                                                                           
   Uncertain Primary Site                                                                                                           
                                                                                                                                    
   Total Animals with Neoplasms Uncertain-                                                                                          
   Benign or Malignant                                                                                                              
     Total Uncertain Neoplasms                                                                                                      
                                                                                                                                    

____________________________________________________________________________________________________________________________________
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Primary tumors: all tumors except metastatic tumors                                                                              
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