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TDMS Study 05184-05 Pathology Tables

NTP                                        STATISTICAL ANALYSIS OF PRIMARY TUMORS                              REPORT: PEIRPT08     
LAB: Battelle Northwest                                      GLUTARALDEHYDE                                    DATE: 09/14/98       
EXPERIMENT: 05184 TEST: 05                                                                                     TIME: 08:28:49       
TEST TYPE:  CHRONIC                             CAGES FROM 0000 TO LAST CAGE                                   PAGE:       1        
CONT: NO1-ES-25335                              ROUTE: RESPIRATORY EXPOSURE WHOLE BODY                         NTP C#: 55425C       
PATHOLOGIST: RENNE, ROGER                                                                                      CAS: 111-30-8        
------------------------------------------------------------------------------------------------------------------------------------
                                                                                                                                    
                                                           2 YEAR CHRONIC                                                           
                                                                                                                                    

               REASONS FOR REMOVAL:    ALL                                                                                          
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
               REMOVAL DATE RANGE:     ALL                                                                                          
                                                                                                                                    
               TREATMENT GROUPS:       INCLUDE ALL                                                                                  
NTP                                        STATISTICAL ANALYSIS OF PRIMARY TUMORS                              REPORT: PEIRPT08
LAB: Battelle Northwest                                      GLUTARALDEHYDE                                    DATE: 09/14/98

EXPERIMENT: 05184 TEST: 05                                                                                     TIME: 08:28:49
TEST TYPE:  CHRONIC                             CAGES FROM 0000 TO LAST CAGE
CONT: NO1-ES-25335                              ROUTE: RESPIRATORY EXPOSURE WHOLE BODY                         NTP C#: 55425C
PATHOLOGIST: RENNE, ROGER                                                                                      CAS: 111-30-8

Rats(FISCHER 344)
-----------------------------
FOR ALL DOSES THE TUMOR RATES IN THE FOLLOWING TISSUES/ORGANS ARE
BASED ON NUMBER OF TISSUES EXAMINED.  IN OTHER TISSUES/ORGANS RATES
ARE BASED ON THE NUMBER OF ANIMALS NECROPSIED.
                                                 ---------------
                                                 Adrenal Cortex
                                                 Adrenal Medulla
                                                 Clitoral/Preputial Gland
                                                 Islets, Pancreatic
                                                 Kidney
                                                 Liver
                                                 Lung
                                                 Ovary
                                                 Pancreas
                                                 Pituitary Gland
                                                 Testes
                                                 Thyroid Gland
                                                 Urinary Bladder
NTP                                        STATISTICAL ANALYSIS OF PRIMARY TUMORS                              REPORT: PEIRPT08   
LAB: Battelle Northwest                                      GLUTARALDEHYDE                                    DATE: 09/14/98     
EXPERIMENT: 05184 TEST: 05                                                                                     TIME: 08:28:49     
TEST TYPE:  CHRONIC                             CAGES FROM 0000 TO LAST CAGE                                                      
CONT: NO1-ES-25335                              ROUTE: RESPIRATORY EXPOSURE WHOLE BODY                         NTP C#: 55425C     
PATHOLOGIST: RENNE, ROGER                                                                                      CAS: 111-30-8      



SUMMARY OF STATISTICALLY SIGNIFICANT (P<=.05) RESULTS
IN THE ANALYSIS OF                  GLUTARALDEHYDE
===============================================================

Male Rats
------------
Organ                                 Morphology
-----                                 ----------
Pituitary Gland: Pars Distalis or Unspecified Site
                                       Adenoma
Skin                                   Fibroma
                                       Fibroma, Fibrosarcoma, Sarcoma, Myxoma, Myxosarcoma, or Fibrous Histiocytoma
Testes                                 Adenoma
All Organs                             Benign Tumors
                                       Malignant Tumors
                                       Malignant and Benign Tumors
===============================================================
Female Rats
------------
Organ                                  Morphology
-----                                  ----------
Clitoral/Preputial Gland               Adenoma
                                       Carcinoma or Adenoma
Mammary Gland                          Carcinoma
                                       Carcinoma or Adenoma
                                       Fibroadenoma
                                       Fibroma, Fibroadenoma or Adenoma
                                       Fibroma, Fibroadenoma, Carcinoma, or Adenoma
Mesentery                              Sarcoma
Pituitary Gland: Pars Distalis or Unspecified Site
                                       Adenoma
Skin                                   Fibrosarcoma, Sarcoma, Myxosarcoma, or Fibrous Histiocytoma
Thyroid Gland: Follicular Cell         Adenoma
                                       Carcinoma or Adenoma
All Organs                             Leukemia: Lymphocytic, Monocytic, Mononuclear, or Undifferentiated
                                       Benign Tumors
                                       Malignant Tumors
                                       Malignant and Benign Tumors
===============================================================
       Date:  09/14/98                           EXPERIMENT: 05184 TEST: 05                                            Page 1
                     Statistical Analysis of Primary Tumors in Rats(FISCHER 344)        -                   GLUTARALDEHYDE
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      250 PPB      500 PPB      750 PPB     |CONTROL      250 PPB      500 PPB      750 PPB      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Adrenal Medulla                                                                                                                  |
|     Pheochromocytoma Benign                                                                                                     |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     4/50 (8%)    5/50 (10%)   6/50 (12%)   2/49 (4%)   |0/50 (0%)    0/50 (0%)    1/50 (2%)    0/49 (0%)    |
|POLY-3 ADJUSTED (b)|     11.4%        12.7%        16.5%        7.3%        |0.0%         0.0%         2.8%         0.0%         |
|TERMINAL (d)       |     2/12 (17%)   2/14 (14%)   1/9 (11%)    0/6 (0%)    |0/26 (0%)    0/31 (0%)    1/15 (7%)    0/14 (0%)    |
|FIRST INCIDENCE    |     702          632          617          673         |---          ---          730 (T)      ---          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.510      P=0.610      P=0.293      P=0.525N    |P=0.386      (e)          P=0.390      (e)          |
|POLY 3             |     P=0.514N     P=0.571      P=0.386      P=0.456N    |P=0.450      (e)          P=0.469      (e)          |
|POLY 1.5           |     P=0.490N     P=0.543      P=0.383      P=0.444N    |P=0.457      (e)          P=0.482      (e)          |
|POLY 6             |     P=0.535N     P=0.609      P=0.390      P=0.463N    |P=0.447      (e)          P=0.452      (e)          |
|LOGISTIC REGRESSION|     P=0.503N     P=0.612      P=0.352      P=0.487N    |(e)          (e)          P=0.390      (e)          |
|COCH-ARM / FISHERS |     P=0.335N     P=0.500      P=0.370      P=0.349N    |P=0.497      (e)          P=0.500      (e)          |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      250 PPB      500 PPB      750 PPB     |CONTROL      250 PPB      500 PPB      750 PPB      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Adrenal Medulla                                                                                                                  |
|     Pheochromocytoma Malignant                                                                                                  |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     1/50 (2%)    3/50 (6%)    2/50 (4%)    1/49 (2%)   |0/50 (0%)    1/50 (2%)    0/50 (0%)    1/49 (2%)    |
|POLY-3 ADJUSTED (b)|     2.8%         7.6%         5.5%         3.6%        |0.0%         2.3%         0.0%         3.2%         |
|TERMINAL (d)       |     0/12 (0%)    1/14 (7%)    0/9 (0%)     0/6 (0%)    |0/26 (0%)    0/31 (0%)    0/15 (0%)    1/14 (7%)    |
|FIRST INCIDENCE    |     689          579          593          646         |---          437          ---          730 (T)      |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.491      P=0.374      P=0.472      P=0.683     |P=0.283      P=0.496      (e)          P=0.377      |
|POLY 3             |     P=0.541      P=0.344      P=0.509      P=0.704     |P=0.341      P=0.506      (e)          P=0.446      |
|POLY 1.5           |     P=0.550      P=0.329      P=0.507      P=0.709     |P=0.353      P=0.502      (e)          P=0.457      |
|POLY 6             |     P=0.535      P=0.365      P=0.510      P=0.702     |P=0.326      P=0.512      (e)          P=0.435      |
|LOGISTIC REGRESSION|     P=0.559      P=0.340      P=0.504      P=0.708     |P=0.419      P=0.542      (e)          P=0.377      |
|COCH-ARM / FISHERS |     P=0.507N     P=0.309      P=0.500      P=0.747     |P=0.371      P=0.500      (e)          P=0.495      |
|=================================================================================================================================|
       Date:  09/14/98                           EXPERIMENT: 05184 TEST: 05                                            Page 2
                     Statistical Analysis of Primary Tumors in Rats(FISCHER 344)       -                   GLUTARALDEHYDE
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      250 PPB      500 PPB      750 PPB     |CONTROL      250 PPB      500 PPB      750 PPB      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Adrenal Medulla                                                                                                                  |
|     Pheochromocytoma: Benign, Complex, Malignant, NOS                                                                           |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     6/50 (12%)   7/50 (14%)   9/50 (18%)   3/49 (6%)   |0/50 (0%)    1/50 (2%)    1/50 (2%)    1/49 (2%)    |
|POLY-3 ADJUSTED (b)|     17.0%        17.5%        24.2%        10.8%       |0.0%         2.3%         2.8%         3.2%         |
|TERMINAL (d)       |     3/12 (25%)   2/14 (14%)   1/9 (11%)    0/6 (0%)    |0/26 (0%)    0/31 (0%)    1/15 (7%)    1/14 (7%)    |
|FIRST INCIDENCE    |     689          579          593          646         |---          437          730 (T)      730 (T)      |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.493      P=0.595N     P=0.220      P=0.475N    |P=0.181      P=0.496      P=0.390      P=0.377      |
|POLY 3             |     P=0.503N     P=0.595      P=0.317      P=0.370N    |P=0.241      P=0.506      P=0.469      P=0.446      |
|POLY 1.5           |     P=0.477N     P=0.557      P=0.307      P=0.359N    |P=0.256      P=0.502      P=0.482      P=0.457      |
|POLY 6             |     P=0.522N     P=0.598N     P=0.335      P=0.372N    |P=0.226      P=0.512      P=0.452      P=0.435      |
|LOGISTIC REGRESSION|     P=0.475N     P=0.620N     P=0.280      P=0.399N    |P=0.298      P=0.542      P=0.390      P=0.377      |
|COCH-ARM / FISHERS |     P=0.295N     P=0.500      P=0.288      P=0.254N    |P=0.297      P=0.500      P=0.500      P=0.495      |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      250 PPB      500 PPB      750 PPB     |CONTROL      250 PPB      500 PPB      750 PPB      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Clitoral/Preputial Gland                                                                                                         |
|     Adenoma                                                                                                                     |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     1/50 (2%)    2/50 (4%)    0/50 (0%)    0/50 (0%)   |3/49 (6%)    3/50 (6%)    1/50 (2%)    0/50 (0%)    |
|POLY-3 ADJUSTED (b)|     2.9%         5.1%         0.0%         0.0%        |7.3%         7.1%         2.8%         0.0%         |
|TERMINAL (d)       |     1/12 (8%)    1/14 (7%)    0/9 (0%)     0/6 (0%)    |2/26 (8%)    2/31 (7%)    1/15 (7%)    0/14 (0%)    |
|FIRST INCIDENCE    |     729 (T)      495          ---          ---         |694          694          730 (T)      ---          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.228N     P=0.538      P=0.557N     P=0.638N    |P=0.131N     P=0.592N     P=0.503N     P=0.231N     |
|POLY 3             |     P=0.189N     P=0.541      P=0.497N     P=0.548N    |P=0.080N     P=0.650N     P=0.356N     P=0.170N     |
|POLY 1.5           |     P=0.183N     P=0.525      P=0.497N     P=0.541N    |P=0.066N     P=0.655N     P=0.330N     P=0.155N     |
|POLY 6             |     P=0.196N     P=0.561      P=0.499N     P=0.553N    |P=0.098N     P=0.639N     P=0.391N     P=0.186N     |
|LOGISTIC REGRESSION|     P=0.165N     P=0.506      (e)          (e)         |P=0.093N     P=0.632N     P=0.440N     P=0.191N     |
|COCH-ARM / FISHERS |     P=0.149N     P=0.500      P=0.500N     P=0.500N    |P=0.041N*    P=0.651N     P=0.301N     P=0.117N     |
|=================================================================================================================================|
       Date:  09/14/98                           EXPERIMENT: 05184 TEST: 05                                            Page 3
                     Statistical Analysis of Primary Tumors in Rats(FISCHER 344)       -                   GLUTARALDEHYDE
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      250 PPB      500 PPB      750 PPB     |CONTROL      250 PPB      500 PPB      750 PPB      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Clitoral/Preputial Gland                                                                                                         |
|     Carcinoma                                                                                                                   |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     0/50 (0%)    2/50 (4%)    1/50 (2%)    2/50 (4%)   |3/49 (6%)    2/50 (4%)    1/50 (2%)    1/50 (2%)    |
|POLY-3 ADJUSTED (b)|     0.0%         5.1%         2.8%         7.1%        |7.3%         4.8%         2.8%         3.1%         |
|TERMINAL (d)       |     0/12 (0%)    0/14 (0%)    0/9 (0%)     0/6 (0%)    |2/26 (8%)    2/31 (7%)    0/15 (0%)    1/14 (7%)    |
|FIRST INCIDENCE    |     ---          617          689          620         |660          730 (T)      634          730 (T)      |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.137      P=0.300      P=0.460      P=0.206     |P=0.339N     P=0.436N     P=0.459N     P=0.527N     |
|POLY 3             |     P=0.178      P=0.262      P=0.504      P=0.190     |P=0.220N     P=0.490N     P=0.354N     P=0.401N     |
|POLY 1.5           |     P=0.181      P=0.252      P=0.503      P=0.195     |P=0.196N     P=0.494N     P=0.329N     P=0.374N     |
|POLY 6             |     P=0.175      P=0.276      P=0.503      P=0.187     |P=0.249N     P=0.481N     P=0.386N     P=0.429N     |
|LOGISTIC REGRESSION|     P=0.151      P=0.249      P=0.500      P=0.187     |P=0.239N     P=0.471N     P=0.348N     P=0.432N     |
|COCH-ARM / FISHERS |     P=0.209      P=0.247      P=0.500      P=0.247     |P=0.146N     P=0.490N     P=0.301N     P=0.301N     |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      250 PPB      500 PPB      750 PPB     |CONTROL      250 PPB      500 PPB      750 PPB      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Clitoral/Preputial Gland                                                                                                         |
|     Carcinoma or Adenoma                                                                                                        |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     1/50 (2%)    4/50 (8%)    1/50 (2%)    2/50 (4%)   |6/49 (12%)   5/50 (10%)   2/50 (4%)    1/50 (2%)    |
|POLY-3 ADJUSTED (b)|     2.9%         10.0%        2.8%         7.1%        |14.5%        11.8%        5.5%         3.1%         |
|TERMINAL (d)       |     1/12 (8%)    1/14 (7%)    0/9 (0%)     0/6 (0%)    |4/26 (15%)   4/31 (13%)   1/15 (7%)    1/14 (7%)    |
|FIRST INCIDENCE    |     729 (T)      495          689          620         |660          694          634          730 (T)      |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.398      P=0.238      P=0.705      P=0.386     |P=0.107N     P=0.401N     P=0.328N     P=0.197N     |
|POLY 3             |     P=0.502      P=0.218      P=0.758N     P=0.422     |P=0.042N*    P=0.485N     P=0.179N     P=0.109N     |
|POLY 1.5           |     P=0.508      P=0.202      P=0.757N     P=0.431     |P=0.032N*    P=0.491N     P=0.155N     P=0.092N     |
|POLY 6             |     P=0.498      P=0.241      P=0.760N     P=0.419     |P=0.057N     P=0.471N     P=0.214N     P=0.128N     |
|LOGISTIC REGRESSION|     P=0.482      P=0.187      P=0.755      P=0.406     |P=0.054N     P=0.454N     P=0.212N     P=0.129N     |
|COCH-ARM / FISHERS |     P=0.564      P=0.181      P=0.753N     P=0.500     |P=0.016N*    P=0.486N     P=0.128N     P=0.053N     |
|=================================================================================================================================|
       Date:  09/14/98                           EXPERIMENT: 05184 TEST: 05                                            Page 4
                     Statistical Analysis of Primary Tumors in Rats(FISCHER 344)       -                   GLUTARALDEHYDE
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      250 PPB      500 PPB      750 PPB     |CONTROL      250 PPB      500 PPB      750 PPB      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Islets, Pancreatic                                                                                                               |
|     Adenoma                                                                                                                     |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     1/50 (2%)    3/49 (6%)    1/50 (2%)    1/48 (2%)   |0/49 (0%)    1/50 (2%)    0/50 (0%)    0/50 (0%)    |
|POLY-3 ADJUSTED (b)|     2.8%         7.8%         2.8%         3.7%        |0.0%         2.4%         0.0%         0.0%         |
|TERMINAL (d)       |     0/12 (0%)    3/14 (21%)   0/9 (0%)     1/6 (17%)   |0/26 (0%)    1/31 (3%)    0/15 (0%)    0/14 (0%)    |
|FIRST INCIDENCE    |     708          729 (T)      726          729 (T)     |---          730 (T)      ---          ---          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.502      P=0.376      P=0.725      P=0.669     |P=0.614N     P=0.535      (e)          (e)          |
|POLY 3             |     P=0.519N     P=0.338      P=0.759N     P=0.702     |P=0.588N     P=0.506      (e)          (e)          |
|POLY 1.5           |     P=0.508N     P=0.324      P=0.758N     P=0.708     |P=0.562N     P=0.503      (e)          (e)          |
|POLY 6             |     P=0.532N     P=0.356      P=0.763      P=0.697     |P=0.618N     P=0.511      (e)          (e)          |
|LOGISTIC REGRESSION|     P=0.564      P=0.378      P=0.748      P=0.687     |(e)          P=0.535      (e)          (e)          |
|COCH-ARM / FISHERS |     P=0.437N     P=0.301      P=0.753N     P=0.742     |P=0.497N     P=0.505      (e)          (e)          |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      250 PPB      500 PPB      750 PPB     |CONTROL      250 PPB      500 PPB      750 PPB      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Islets, Pancreatic                                                                                                               |
|     Carcinoma                                                                                                                   |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     4/50 (8%)    1/49 (2%)    1/50 (2%)    1/48 (2%)   |0/49 (0%)    0/50 (0%)    1/50 (2%)    0/50 (0%)    |
|POLY-3 ADJUSTED (b)|     11.2%        2.6%         2.8%         3.7%        |0.0%         0.0%         2.8%         0.0%         |
|TERMINAL (d)       |     1/12 (8%)    0/14 (0%)    0/9 (0%)     0/6 (0%)    |0/26 (0%)    0/31 (0%)    0/15 (0%)    0/14 (0%)    |
|FIRST INCIDENCE    |     612          708          702          689         |---          ---          617          ---          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.153N     P=0.133N     P=0.228N     P=0.324N    |P=0.461      (e)          P=0.473      (e)          |
|POLY 3             |     P=0.116N     P=0.152N     P=0.175N     P=0.265N    |P=0.450      (e)          P=0.475      (e)          |
|POLY 1.5           |     P=0.111N     P=0.163N     P=0.174N     P=0.255N    |P=0.460      (e)          P=0.488      (e)          |
|POLY 6             |     P=0.122N     P=0.140N     P=0.179N     P=0.274N    |P=0.444      (e)          P=0.460      (e)          |
|LOGISTIC REGRESSION|     P=0.122N     P=0.135N     P=0.178N     P=0.268N    |P=0.518      (e)          P=0.523      (e)          |
|COCH-ARM / FISHERS |     P=0.089N     P=0.187N     P=0.181N     P=0.194N    |P=0.503      (e)          P=0.505      (e)          |
|=================================================================================================================================|
       Date:  09/14/98                           EXPERIMENT: 05184 TEST: 05                                            Page 5
                     Statistical Analysis of Primary Tumors in Rats(FISCHER 344)       -                   GLUTARALDEHYDE
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      250 PPB      500 PPB      750 PPB     |CONTROL      250 PPB      500 PPB      750 PPB      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Islets, Pancreatic                                                                                                               |
|     Carcinoma or Adenoma                                                                                                        |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     5/50 (10%)   4/49 (8%)    2/50 (4%)    2/48 (4%)   |0/49 (0%)    1/50 (2%)    1/50 (2%)    0/50 (0%)    |
|POLY-3 ADJUSTED (b)|     14.0%        10.3%        5.6%         7.3%        |0.0%         2.4%         2.8%         0.0%         |
|TERMINAL (d)       |     1/12 (8%)    3/14 (21%)   0/9 (0%)     1/6 (17%)   |0/26 (0%)    1/31 (3%)    0/15 (0%)    0/14 (0%)    |
|FIRST INCIDENCE    |     612          708          702          689         |---          730 (T)      617          ---          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.260N     P=0.382N     P=0.285N     P=0.408N    |P=0.524      P=0.535      P=0.473      (e)          |
|POLY 3             |     P=0.158N     P=0.449N     P=0.212N     P=0.333N    |P=0.547      P=0.506      P=0.475      (e)          |
|POLY 1.5           |     P=0.150N     P=0.471N     P=0.211N     P=0.319N    |P=0.567      P=0.503      P=0.488      (e)          |
|POLY 6             |     P=0.169N     P=0.426N     P=0.218N     P=0.347N    |P=0.527      P=0.511      P=0.460      (e)          |
|LOGISTIC REGRESSION|     P=0.179N     P=0.381N     P=0.217N     P=0.341N    |P=0.596      P=0.535      P=0.523      (e)          |
|COCH-ARM / FISHERS |     P=0.107N     P=0.513N     P=0.218N     P=0.235N    |P=0.621N     P=0.505      P=0.505      (e)          |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      250 PPB      500 PPB      750 PPB     |CONTROL      250 PPB      500 PPB      750 PPB      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Kidney: Renal Tubule                                                                                                             |
|     Adenoma                                                                                                                     |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     0/50 (0%)    3/50 (6%)    0/50 (0%)    1/50 (2%)   |0/49 (0%)    0/50 (0%)    0/50 (0%)    0/50 (0%)    |
|POLY-3 ADJUSTED (b)|     0.0%         7.7%         0.0%         3.6%        |0.0%         0.0%         0.0%         0.0%         |
|TERMINAL (d)       |     0/12 (0%)    0/14 (0%)    0/9 (0%)     0/6 (0%)    |0/26 (0%)    0/31 (0%)    0/15 (0%)    0/14 (0%)    |
|FIRST INCIDENCE    |     ---          675          ---          720         |---          ---          ---          ---          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.454      P=0.156      (e)          P=0.419     |(e)          (e)          (e)          (e)          |
|POLY 3             |     P=0.559      P=0.137      (e)          P=0.453     |(e)          (e)          (e)          (e)          |
|POLY 1.5           |     P=0.561      P=0.130      (e)          P=0.459     |(e)          (e)          (e)          (e)          |
|POLY 6             |     P=0.556      P=0.148      (e)          P=0.448     |(e)          (e)          (e)          (e)          |
|LOGISTIC REGRESSION|     P=0.493      P=0.152      (e)          P=0.428     |(e)          (e)          (e)          (e)          |
|COCH-ARM / FISHERS |     P=0.589      P=0.121      (e)          P=0.500     |(e)          (e)          (e)          (e)          |
|=================================================================================================================================|
       Date:  09/14/98                           EXPERIMENT: 05184 TEST: 05                                            Page 6
                     Statistical Analysis of Primary Tumors in Rats(FISCHER 344)       -                   GLUTARALDEHYDE
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      250 PPB      500 PPB      750 PPB     |CONTROL      250 PPB      500 PPB      750 PPB      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Kidney: Renal Tubule                                                                                                             |
|     Carcinoma or Adenoma                                                                                                        |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     0/50 (0%)    3/50 (6%)    0/50 (0%)    2/50 (4%)   |0/49 (0%)    0/50 (0%)    0/50 (0%)    0/50 (0%)    |
|POLY-3 ADJUSTED (b)|     0.0%         7.7%         0.0%         7.2%        |0.0%         0.0%         0.0%         0.0%         |
|TERMINAL (d)       |     0/12 (0%)    0/14 (0%)    0/9 (0%)     0/6 (0%)    |0/26 (0%)    0/31 (0%)    0/15 (0%)    0/14 (0%)    |
|FIRST INCIDENCE    |     ---          675          ---          652         |---          ---          ---          ---          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.212      P=0.156      (e)          P=0.161     |(e)          (e)          (e)          (e)          |
|POLY 3             |     P=0.322      P=0.137      (e)          P=0.189     |(e)          (e)          (e)          (e)          |
|POLY 1.5           |     P=0.323      P=0.130      (e)          P=0.195     |(e)          (e)          (e)          (e)          |
|POLY 6             |     P=0.319      P=0.148      (e)          P=0.185     |(e)          (e)          (e)          (e)          |
|LOGISTIC REGRESSION|     P=0.247      P=0.152      (e)          P=0.179     |(e)          (e)          (e)          (e)          |
|COCH-ARM / FISHERS |     P=0.343      P=0.121      (e)          P=0.247     |(e)          (e)          (e)          (e)          |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      250 PPB      500 PPB      750 PPB     |CONTROL      250 PPB      500 PPB      750 PPB      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Lung                                                                                                                             |
|     Alveolar/Bronchiolar Adenoma                                                                                                |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     0/50 (0%)    1/50 (2%)    1/50 (2%)    2/50 (4%)   |0/50 (0%)    0/50 (0%)    1/50 (2%)    0/49 (0%)    |
|POLY-3 ADJUSTED (b)|     0.0%         2.6%         2.8%         7.1%        |0.0%         0.0%         2.8%         0.0%         |
|TERMINAL (d)       |     0/12 (0%)    1/14 (7%)    0/9 (0%)     1/6 (17%)   |0/26 (0%)    0/31 (0%)    1/15 (7%)    0/14 (0%)    |
|FIRST INCIDENCE    |     ---          729 (T)      533          589         |---          ---          730 (T)      ---          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.060      P=0.531      P=0.495      P=0.150     |P=0.386      (e)          P=0.390      (e)          |
|POLY 3             |     P=0.114      P=0.520      P=0.506      P=0.190     |P=0.450      (e)          P=0.469      (e)          |
|POLY 1.5           |     P=0.116      P=0.512      P=0.505      P=0.195     |P=0.457      (e)          P=0.482      (e)          |
|POLY 6             |     P=0.112      P=0.530      P=0.507      P=0.186     |P=0.447      (e)          P=0.452      (e)          |
|LOGISTIC REGRESSION|     P=0.102      P=0.531      P=0.458      P=0.189     |(e)          (e)          P=0.390      (e)          |
|COCH-ARM / FISHERS |     P=0.129      P=0.500      P=0.500      P=0.247     |P=0.497      (e)          P=0.500      (e)          |
|=================================================================================================================================|
       Date:  09/14/98                           EXPERIMENT: 05184 TEST: 05                                            Page 7
                     Statistical Analysis of Primary Tumors in Rats(FISCHER 344)       -                   GLUTARALDEHYDE
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      250 PPB      500 PPB      750 PPB     |CONTROL      250 PPB      500 PPB      750 PPB      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Lung                                                                                                                             |
|     Alveolar/Bronchiolar Carcinoma or Alveolar/Bronchiolar                                                                      |
|     Adenoma                                                                                                                     |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     0/50 (0%)    1/50 (2%)    1/50 (2%)    2/50 (4%)   |0/50 (0%)    0/50 (0%)    1/50 (2%)    0/49 (0%)    |
|POLY-3 ADJUSTED (b)|     0.0%         2.6%         2.8%         7.1%        |0.0%         0.0%         2.8%         0.0%         |
|TERMINAL (d)       |     0/12 (0%)    1/14 (7%)    0/9 (0%)     1/6 (17%)   |0/26 (0%)    0/31 (0%)    1/15 (7%)    0/14 (0%)    |
|FIRST INCIDENCE    |     ---          729 (T)      533          589         |---          ---          730 (T)      ---          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.060      P=0.531      P=0.495      P=0.150     |P=0.386      (e)          P=0.390      (e)          |
|POLY 3             |     P=0.114      P=0.520      P=0.506      P=0.190     |P=0.450      (e)          P=0.469      (e)          |
|POLY 1.5           |     P=0.116      P=0.512      P=0.505      P=0.195     |P=0.457      (e)          P=0.482      (e)          |
|POLY 6             |     P=0.112      P=0.530      P=0.507      P=0.186     |P=0.447      (e)          P=0.452      (e)          |
|LOGISTIC REGRESSION|     P=0.102      P=0.531      P=0.458      P=0.189     |(e)          (e)          P=0.390      (e)          |
|COCH-ARM / FISHERS |     P=0.129      P=0.500      P=0.500      P=0.247     |P=0.497      (e)          P=0.500      (e)          |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      250 PPB      500 PPB      750 PPB     |CONTROL      250 PPB      500 PPB      750 PPB      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Mammary Gland                                                                                                                    |
|     Carcinoma                                                                                                                   |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     1/50 (2%)    2/50 (4%)    0/50 (0%)    0/50 (0%)   |5/50 (10%)   8/50 (16%)   3/50 (6%)    1/50 (2%)    |
|POLY-3 ADJUSTED (b)|     2.8%         5.2%         0.0%         0.0%        |11.8%        18.5%        8.2%         3.1%         |
|TERMINAL (d)       |     0/12 (0%)    1/14 (7%)    0/9 (0%)     0/6 (0%)    |3/26 (12%)   5/31 (16%)   0/15 (0%)    0/14 (0%)    |
|FIRST INCIDENCE    |     694          708          ---          ---         |589          593          654          463          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.216N     P=0.580      P=0.545N     P=0.571N    |P=0.162N     P=0.358      P=0.586N     P=0.243N     |
|POLY 3             |     P=0.190N     P=0.534      P=0.498N     P=0.548N    |P=0.097N     P=0.289      P=0.441N     P=0.173N     |
|POLY 1.5           |     P=0.183N     P=0.521      P=0.497N     P=0.541N    |P=0.074N     P=0.277      P=0.405N     P=0.153N     |
|POLY 6             |     P=0.197N     P=0.551      P=0.501N     P=0.554N    |P=0.128N     P=0.312      P=0.486N     P=0.193N     |
|LOGISTIC REGRESSION|     P=0.189N     P=0.568      P=0.502N     P=0.556N    |P=0.053N     P=0.275      P=0.421N     P=0.122N     |
|COCH-ARM / FISHERS |     P=0.149N     P=0.500      P=0.500N     P=0.500N    |P=0.035N*    P=0.277      P=0.357N     P=0.102N     |
|=================================================================================================================================|
       Date:  09/14/98                           EXPERIMENT: 05184 TEST: 05                                            Page 8
                     Statistical Analysis of Primary Tumors in Rats(FISCHER 344)       -                   GLUTARALDEHYDE
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      250 PPB      500 PPB      750 PPB     |CONTROL      250 PPB      500 PPB      750 PPB      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Mammary Gland                                                                                                                    |
|     Carcinoma or Adenoma                                                                                                        |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     1/50 (2%)    2/50 (4%)    0/50 (0%)    1/50 (2%)   |5/50 (10%)   8/50 (16%)   3/50 (6%)    1/50 (2%)    |
|POLY-3 ADJUSTED (b)|     2.8%         5.2%         0.0%         3.6%        |11.8%        18.5%        8.2%         3.1%         |
|TERMINAL (d)       |     0/12 (0%)    1/14 (7%)    0/9 (0%)     0/6 (0%)    |3/26 (12%)   5/31 (16%)   0/15 (0%)    0/14 (0%)    |
|FIRST INCIDENCE    |     694          708          ---          638         |589          593          654          463          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.530N     P=0.580      P=0.545N     P=0.693     |P=0.162N     P=0.358      P=0.586N     P=0.243N     |
|POLY 3             |     P=0.457N     P=0.534      P=0.498N     P=0.707     |P=0.097N     P=0.289      P=0.441N     P=0.173N     |
|POLY 1.5           |     P=0.451N     P=0.521      P=0.497N     P=0.714     |P=0.074N     P=0.277      P=0.405N     P=0.153N     |
|POLY 6             |     P=0.465N     P=0.551      P=0.501N     P=0.703     |P=0.128N     P=0.312      P=0.486N     P=0.193N     |
|LOGISTIC REGRESSION|     P=0.491N     P=0.568      P=0.502N     P=0.711     |P=0.053N     P=0.275      P=0.421N     P=0.122N     |
|COCH-ARM / FISHERS |     P=0.411N     P=0.500      P=0.500N     P=0.753N    |P=0.035N*    P=0.277      P=0.357N     P=0.102N     |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      250 PPB      500 PPB      750 PPB     |CONTROL      250 PPB      500 PPB      750 PPB      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Mammary Gland                                                                                                                    |
|     Fibroadenoma                                                                                                                |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     1/50 (2%)    3/50 (6%)    2/50 (4%)    2/50 (4%)   |24/50 (48%)  23/50 (46%)  18/50 (36%)  10/50 (20%)  |
|POLY-3 ADJUSTED (b)|     2.8%         7.7%         5.6%         7.1%        |54.6%        52.2%        45.4%        28.9%        |
|TERMINAL (d)       |     0/12 (0%)    2/14 (14%)   1/9 (11%)    1/6 (17%)   |14/26 (54%)  16/31 (52%)  5/15 (33%)   2/14 (14%)   |
|FIRST INCIDENCE    |     657          712          721          508         |566          561          533          514          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.225      P=0.383      P=0.462      P=0.360     |P=0.270N     P=0.289N     P=0.391      P=0.170N     |
|POLY 3             |     P=0.354      P=0.338      P=0.502      P=0.422     |P=0.014N*    P=0.496N     P=0.263N     P=0.017N*    |
|POLY 1.5           |     P=0.365      P=0.326      P=0.504      P=0.431     |P=0.008N**   P=0.512N     P=0.212N     P=0.011N*    |
|POLY 6             |     P=0.341      P=0.353      P=0.497      P=0.415     |P=0.024N*    P=0.467N     P=0.326N     P=0.023N*    |
|LOGISTIC REGRESSION|     P=0.319      P=0.371      P=0.492      P=0.446     |P=0.017N*    P=0.486N     P=0.330N     P=0.022N*    |
|COCH-ARM / FISHERS |     P=0.436      P=0.309      P=0.500      P=0.500     |P<0.001N**   P=0.500N     P=0.156N     P=0.003N**   |
|=================================================================================================================================|
       Date:  09/14/98                           EXPERIMENT: 05184 TEST: 05                                            Page 9
                     Statistical Analysis of Primary Tumors in Rats(FISCHER 344)       -                   GLUTARALDEHYDE
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      250 PPB      500 PPB      750 PPB     |CONTROL      250 PPB      500 PPB      750 PPB      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Mammary Gland                                                                                                                    |
|     Fibroma, Fibroadenoma or Adenoma                                                                                            |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     1/50 (2%)    3/50 (6%)    2/50 (4%)    3/50 (6%)   |24/50 (48%)  23/50 (46%)  18/50 (36%)  10/50 (20%)  |
|POLY-3 ADJUSTED (b)|     2.8%         7.7%         5.6%         10.5%       |54.6%        52.2%        45.4%        28.9%        |
|TERMINAL (d)       |     0/12 (0%)    2/14 (14%)   1/9 (11%)    1/6 (17%)   |14/26 (54%)  16/31 (52%)  5/15 (33%)   2/14 (14%)   |
|FIRST INCIDENCE    |     657          712          721          508         |566          561          533          514          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.109      P=0.383      P=0.462      P=0.189     |P=0.270N     P=0.289N     P=0.391      P=0.170N     |
|POLY 3             |     P=0.212      P=0.338      P=0.502      P=0.231     |P=0.014N*    P=0.496N     P=0.263N     P=0.017N*    |
|POLY 1.5           |     P=0.220      P=0.326      P=0.504      P=0.239     |P=0.008N**   P=0.512N     P=0.212N     P=0.011N*    |
|POLY 6             |     P=0.203      P=0.353      P=0.497      P=0.227     |P=0.024N*    P=0.467N     P=0.326N     P=0.023N*    |
|LOGISTIC REGRESSION|     P=0.173      P=0.371      P=0.492      P=0.248     |P=0.017N*    P=0.486N     P=0.330N     P=0.022N*    |
|COCH-ARM / FISHERS |     P=0.271      P=0.309      P=0.500      P=0.309     |P<0.001N**   P=0.500N     P=0.156N     P=0.003N**   |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      250 PPB      500 PPB      750 PPB     |CONTROL      250 PPB      500 PPB      750 PPB      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Mammary Gland                                                                                                                    |
|     Fibroma, Fibroadenoma, Carcinoma, or Adenoma                                                                                |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     2/50 (4%)    5/50 (10%)   2/50 (4%)    3/50 (6%)   |26/50 (52%)  27/50 (54%)  21/50 (42%)  11/50 (22%)  |
|POLY-3 ADJUSTED (b)|     5.6%         12.9%        5.6%         10.5%       |58.5%        60.1%        52.1%        31.1%        |
|TERMINAL (d)       |     0/12 (0%)    3/14 (21%)   1/9 (11%)    1/6 (17%)   |15/26 (58%)  18/31 (58%)  5/15 (33%)   2/14 (14%)   |
|FIRST INCIDENCE    |     657          708          721          508         |566          561          533          463          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.302      P=0.316      P=0.642      P=0.341     |P=0.278N     P=0.405N     P=0.285      P=0.159N     |
|POLY 3             |     P=0.464      P=0.252      P=0.695N     P=0.401     |P=0.010N*    P=0.524      P=0.349N     P=0.011N*    |
|POLY 1.5           |     P=0.476      P=0.239      P=0.691N     P=0.412     |P=0.005N**   P=0.497      P=0.287N     P=0.007N**   |
|POLY 6             |     P=0.450      P=0.267      P=0.691      P=0.395     |P=0.017N*    P=0.571      P=0.413N     P=0.015N*    |
|LOGISTIC REGRESSION|     P=0.407      P=0.294      P=0.691      P=0.414     |P=0.009N**   P=0.500      P=0.414N     P=0.013N*    |
|COCH-ARM / FISHERS |     P=0.553      P=0.218      P=0.691N     P=0.500     |P<0.001N**   P=0.500      P=0.212N     P=0.002N**   |
|=================================================================================================================================|
       Date:  09/14/98                           EXPERIMENT: 05184 TEST: 05                                            Page 10
                     Statistical Analysis of Primary Tumors in Rats(FISCHER 344)       -                   GLUTARALDEHYDE
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      250 PPB      500 PPB      750 PPB     |CONTROL      250 PPB      500 PPB      750 PPB      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Mesentery                                                                                                                        |
|     Sarcoma                                                                                                                     |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     0/50 (0%)    0/50 (0%)    0/50 (0%)    0/50 (0%)   |2/50 (4%)    0/50 (0%)    0/50 (0%)    0/50 (0%)    |
|POLY-3 ADJUSTED (b)|     0.0%         0.0%         0.0%         0.0%        |4.7%         0.0%         0.0%         0.0%         |
|TERMINAL (d)       |     0/12 (0%)    0/14 (0%)    0/9 (0%)     0/6 (0%)    |0/26 (0%)    0/31 (0%)    0/15 (0%)    0/14 (0%)    |
|FIRST INCIDENCE    |     ---          ---          ---          ---         |518          ---          ---          ---          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     (e)          (e)          (e)          (e)         |P=0.086N     P=0.222N     P=0.313N     P=0.353N     |
|POLY 3             |     (e)          (e)          (e)          (e)         |P=0.068N     P=0.238N     P=0.277N     P=0.305N     |
|POLY 1.5           |     (e)          (e)          (e)          (e)         |P=0.063N     P=0.240N     P=0.259N     P=0.287N     |
|POLY 6             |     (e)          (e)          (e)          (e)         |P=0.075N     P=0.234N     P=0.300N     P=0.323N     |
|LOGISTIC REGRESSION|     (e)          (e)          (e)          (e)         |P=0.045N*    P=0.229N     P=0.216N     P=0.224N     |
|COCH-ARM / FISHERS |     (e)          (e)          (e)          (e)         |P=0.056N     P=0.247N     P=0.247N     P=0.247N     |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      250 PPB      500 PPB      750 PPB     |CONTROL      250 PPB      500 PPB      750 PPB      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Oral Cavity (Oral Mucosa, Tongue, Pharynx, Tooth, Gingiva)                                                                       |
|     Papilloma Squamous or Papilloma                                                                                             |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     0/50 (0%)    1/50 (2%)    0/50 (0%)    2/50 (4%)   |1/50 (2%)    0/50 (0%)    0/50 (0%)    0/50 (0%)    |
|POLY-3 ADJUSTED (b)|     0.0%         2.6%         0.0%         7.3%        |2.4%         0.0%         0.0%         0.0%         |
|TERMINAL (d)       |     0/12 (0%)    0/14 (0%)    0/9 (0%)     1/6 (17%)   |0/26 (0%)    0/31 (0%)    0/15 (0%)    0/14 (0%)    |
|FIRST INCIDENCE    |     ---          675          ---          720         |698          ---          ---          ---          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.075      P=0.532      (e)          P=0.130     |P=0.228N     P=0.482N     P=0.578N     P=0.568N     |
|POLY 3             |     P=0.156      P=0.521      (e)          P=0.187     |P=0.215N     P=0.499N     P=0.531N     P=0.553N     |
|POLY 1.5           |     P=0.154      P=0.513      (e)          P=0.194     |P=0.205N     P=0.501N     P=0.518N     P=0.540N     |
|POLY 6             |     P=0.154      P=0.532      (e)          P=0.181     |P=0.227N     P=0.494N     P=0.549N     P=0.565N     |
|LOGISTIC REGRESSION|     P=0.092      P=0.519      (e)          P=0.145     |P=0.211N     P=0.499N     P=0.541N     P=0.558N     |
|COCH-ARM / FISHERS |     P=0.149      P=0.500      (e)          P=0.247     |P=0.185N     P=0.500N     P=0.500N     P=0.500N     |
|=================================================================================================================================|
       Date:  09/14/98                           EXPERIMENT: 05184 TEST: 05                                            Page 11
                     Statistical Analysis of Primary Tumors in Rats(FISCHER 344)       -                   GLUTARALDEHYDE
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      250 PPB      500 PPB      750 PPB     |CONTROL      250 PPB      500 PPB      750 PPB      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Oral Cavity (Oral Mucosa, Tongue, Pharynx, Tooth, Gingiva)                                                                       |
|     Squamous Cell Carcinoma, Papilloma Squamous, or Papilloma                                                                   |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     0/50 (0%)    1/50 (2%)    1/50 (2%)    2/50 (4%)   |2/50 (4%)    0/50 (0%)    0/50 (0%)    1/50 (2%)    |
|POLY-3 ADJUSTED (b)|     0.0%         2.6%         2.8%         7.3%        |4.8%         0.0%         0.0%         3.1%         |
|TERMINAL (d)       |     0/12 (0%)    0/14 (0%)    0/9 (0%)     1/6 (17%)   |0/26 (0%)    0/31 (0%)    0/15 (0%)    0/14 (0%)    |
|FIRST INCIDENCE    |     ---          675          688          720         |666          ---          ---          512          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.059      P=0.532      P=0.481      P=0.130     |P=0.394N     P=0.227N     P=0.324N     P=0.617N     |
|POLY 3             |     P=0.112      P=0.521      P=0.504      P=0.187     |P=0.335N     P=0.237N     P=0.275N     P=0.587N     |
|POLY 1.5           |     P=0.114      P=0.513      P=0.503      P=0.194     |P=0.321N     P=0.239N     P=0.258N     P=0.567N     |
|POLY 6             |     P=0.109      P=0.532      P=0.503      P=0.181     |P=0.353N     P=0.232N     P=0.298N     P=0.607N     |
|LOGISTIC REGRESSION|     P=0.075      P=0.519      P=0.500      P=0.145     |P=0.281N     P=0.238N     P=0.259N     P=0.502N     |
|COCH-ARM / FISHERS |     P=0.129      P=0.500      P=0.500      P=0.247     |P=0.301N     P=0.247N     P=0.247N     P=0.500N     |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      250 PPB      500 PPB      750 PPB     |CONTROL      250 PPB      500 PPB      750 PPB      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Pituitary Gland: Pars Distalis or Unspecified Site                                                                               |
|     Adenoma                                                                                                                     |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     32/50 (64%)  26/49 (53%)  26/50 (52%)  20/50 (40%) |37/50 (74%)  37/50 (74%)  27/50 (54%)  24/49 (49%)  |
|POLY-3 ADJUSTED (b)|     71.0%        62.2%        58.8%        61.0%       |81.1%        80.2%        64.5%        66.7%        |
|TERMINAL (d)       |     8/12 (67%)   10/14 (71%)  3/9 (33%)    4/6 (67%)   |22/26 (85%)  26/31 (84%)  9/15 (60%)   9/14 (64%)   |
|FIRST INCIDENCE    |     392          550          393          502         |542          561          469          474          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.437N     P=0.068N     P=0.303N     P=0.393N    |P=0.304      P=0.256N     P=0.377      P=0.457      |
|POLY 3             |     P=0.136N     P=0.246N     P=0.149N     P=0.237N    |P=0.022N*    P=0.562N     P=0.050N     P=0.092N     |
|POLY 1.5           |     P=0.101N     P=0.205N     P=0.142N     P=0.152N    |P=0.011N*    P=0.599      P=0.037N*    P=0.061N     |
|POLY 6             |     P=0.171N     P=0.319N     P=0.161N     P=0.332N    |P=0.042N*    P=0.471N     P=0.072N     P=0.124N     |
|LOGISTIC REGRESSION|     P=0.065N     P=0.126N     P=0.162N     P=0.083N    |P=0.044N*    P=0.573      P=0.107N     P=0.155N     |
|COCH-ARM / FISHERS |     P=0.012N*    P=0.184N     P=0.156N     P=0.014N*   |P<0.001N**   P=0.590N     P=0.030N*    P=0.009N**   |
|=================================================================================================================================|
       Date:  09/14/98                           EXPERIMENT: 05184 TEST: 05                                            Page 12
                     Statistical Analysis of Primary Tumors in Rats(FISCHER 344)       -                   GLUTARALDEHYDE
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      250 PPB      500 PPB      750 PPB     |CONTROL      250 PPB      500 PPB      750 PPB      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Skin                                                                                                                             |
|     Basal or Sq. Cell Carcinoma, Carcinoma, Basosq. Tumor                                                                       |
|     (M or B), Basal Cell Adenoma, Adenoma, Papilloma, Sq Papilloma, Keratoacanthoma, Trichoepitheliom                           |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     1/50 (2%)    6/50 (12%)   4/50 (8%)    3/50 (6%)   |3/50 (6%)    1/50 (2%)    1/50 (2%)    0/50 (0%)    |
|POLY-3 ADJUSTED (b)|     2.8%         15.1%        11.1%        10.5%       |7.1%         2.4%         2.8%         0.0%         |
|TERMINAL (d)       |     0/12 (0%)    2/14 (14%)   1/9 (11%)    1/6 (17%)   |1/26 (4%)    1/31 (3%)    1/15 (7%)    0/14 (0%)    |
|FIRST INCIDENCE    |     652          638          617          502         |680          730 (T)      730 (T)      ---          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.162      P=0.105      P=0.173      P=0.181     |P=0.130N     P=0.272N     P=0.497N     P=0.221N     |
|POLY 3             |     P=0.240      P=0.074      P=0.183      P=0.231     |P=0.085N     P=0.305N     P=0.366N     P=0.176N     |
|POLY 1.5           |     P=0.252      P=0.067      P=0.183      P=0.239     |P=0.074N     P=0.308N     P=0.339N     P=0.160N     |
|POLY 6             |     P=0.230      P=0.086      P=0.180      P=0.226     |P=0.099N     P=0.297N     P=0.402N     P=0.193N     |
|LOGISTIC REGRESSION|     P=0.239      P=0.075      P=0.181      P=0.248     |P=0.091N     P=0.299N     P=0.396N     P=0.172N     |
|COCH-ARM / FISHERS |     P=0.355      P=0.056      P=0.181      P=0.309     |P=0.053N     P=0.309N     P=0.309N     P=0.121N     |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      250 PPB      500 PPB      750 PPB     |CONTROL      250 PPB      500 PPB      750 PPB      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Skin                                                                                                                             |
|     Fibroma                                                                                                                     |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     4/50 (8%)    3/50 (6%)    0/50 (0%)    1/50 (2%)   |0/50 (0%)    0/50 (0%)    1/50 (2%)    0/50 (0%)    |
|POLY-3 ADJUSTED (b)|     11.2%        7.6%         0.0%         3.6%        |0.0%         0.0%         2.8%         0.0%         |
|TERMINAL (d)       |     1/12 (8%)    1/14 (7%)    0/9 (0%)     1/6 (17%)   |0/26 (0%)    0/31 (0%)    0/15 (0%)    0/14 (0%)    |
|FIRST INCIDENCE    |     638          550          ---          729 (T)     |---          ---          619          ---          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.088N     P=0.409N     P=0.088N     P=0.346N    |P=0.460      (e)          P=0.462      (e)          |
|POLY 3             |     P=0.051N     P=0.444N     P=0.059N     P=0.264N    |P=0.448      (e)          P=0.471      (e)          |
|POLY 1.5           |     P=0.048N*    P=0.465N     P=0.058N     P=0.250N    |P=0.457      (e)          P=0.484      (e)          |
|POLY 6             |     P=0.055N     P=0.419N     P=0.060N     P=0.280N    |P=0.442      (e)          P=0.457      (e)          |
|LOGISTIC REGRESSION|     P=0.055N     P=0.455N     P=0.061N     P=0.269N    |P=0.514      (e)          P=0.518      (e)          |
|COCH-ARM / FISHERS |     P=0.038N*    P=0.500N     P=0.059N     P=0.181N    |P=0.500      (e)          P=0.500      (e)          |
|=================================================================================================================================|
       Date:  09/14/98                           EXPERIMENT: 05184 TEST: 05                                            Page 13
                     Statistical Analysis of Primary Tumors in Rats(FISCHER 344)       -                   GLUTARALDEHYDE
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      250 PPB      500 PPB      750 PPB     |CONTROL      250 PPB      500 PPB      750 PPB      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Skin                                                                                                                             |
|     Fibroma, Fibrosarcoma, Sarcoma, Myxoma, Myxosarcoma,                                                                        |
|     or Fibrous Histiocytoma                                                                                                     |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     4/50 (8%)    5/50 (10%)   1/50 (2%)    1/50 (2%)   |2/50 (4%)    1/50 (2%)    1/50 (2%)    0/50 (0%)    |
|POLY-3 ADJUSTED (b)|     11.2%        12.5%        2.8%         3.6%        |4.7%         2.4%         2.8%         0.0%         |
|TERMINAL (d)       |     1/12 (8%)    2/14 (14%)   0/9 (0%)     1/6 (17%)   |0/26 (0%)    0/31 (0%)    0/15 (0%)    0/14 (0%)    |
|FIRST INCIDENCE    |     638          533          666          729 (T)     |533          674          619          ---          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.123N     P=0.597      P=0.223N     P=0.346N    |P=0.198N     P=0.499N     P=0.570N     P=0.332N     |
|POLY 3             |     P=0.079N     P=0.574      P=0.174N     P=0.264N    |P=0.196N     P=0.502N     P=0.557N     P=0.306N     |
|POLY 1.5           |     P=0.073N     P=0.546      P=0.174N     P=0.250N    |P=0.176N     P=0.504N     P=0.533N     P=0.288N     |
|POLY 6             |     P=0.088N     P=0.609      P=0.178N     P=0.280N    |P=0.220N     P=0.496N     P=0.587N     P=0.326N     |
|LOGISTIC REGRESSION|     P=0.072N     P=0.533      P=0.176N     P=0.269N    |P=0.109N     P=0.489N     P=0.459N     P=0.203N     |
|COCH-ARM / FISHERS |     P=0.048N*    P=0.500      P=0.181N     P=0.181N    |P=0.129N     P=0.500N     P=0.500N     P=0.247N     |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      250 PPB      500 PPB      750 PPB     |CONTROL      250 PPB      500 PPB      750 PPB      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Skin                                                                                                                             |
|     Fibrosarcoma                                                                                                                |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     0/50 (0%)    2/50 (4%)    0/50 (0%)    0/50 (0%)   |1/50 (2%)    1/50 (2%)    0/50 (0%)    0/50 (0%)    |
|POLY-3 ADJUSTED (b)|     0.0%         5.1%         0.0%         0.0%        |2.4%         2.4%         0.0%         0.0%         |
|TERMINAL (d)       |     0/12 (0%)    1/14 (7%)    0/9 (0%)     0/6 (0%)    |0/26 (0%)    0/31 (0%)    0/15 (0%)    0/14 (0%)    |
|FIRST INCIDENCE    |     ---          533          ---          ---         |533          674          ---          ---          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.470N     P=0.267      (e)          (e)         |P=0.223N     P=0.760N     P=0.522N     P=0.569N     |
|POLY 3             |     P=0.443N     P=0.263      (e)          (e)         |P=0.229N     P=0.761      P=0.534N     P=0.555N     |
|POLY 1.5           |     P=0.434N     P=0.253      (e)          (e)         |P=0.209N     P=0.759      P=0.519N     P=0.541N     |
|POLY 6             |     P=0.451N     P=0.277      (e)          (e)         |P=0.252N     P=0.756N     P=0.552N     P=0.568N     |
|LOGISTIC REGRESSION|     P=0.387N     P=0.224      (e)          (e)         |P=0.140N     P=0.754N     P=0.472N     P=0.433N     |
|COCH-ARM / FISHERS |     P=0.375N     P=0.247      (e)          (e)         |P=0.170N     P=0.753N     P=0.500N     P=0.500N     |
|=================================================================================================================================|
       Date:  09/14/98                           EXPERIMENT: 05184 TEST: 05                                            Page 14
                     Statistical Analysis of Primary Tumors in Rats(FISCHER 344)       -                   GLUTARALDEHYDE
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      250 PPB      500 PPB      750 PPB     |CONTROL      250 PPB      500 PPB      750 PPB      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Skin                                                                                                                             |
|     Fibrosarcoma, Sarcoma, Myxosarcoma, or Fibrous Histiocytoma                                                                 |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     0/50 (0%)    2/50 (4%)    1/50 (2%)    0/50 (0%)   |2/50 (4%)    1/50 (2%)    0/50 (0%)    0/50 (0%)    |
|POLY-3 ADJUSTED (b)|     0.0%         5.1%         2.8%         0.0%        |4.7%         2.4%         0.0%         0.0%         |
|TERMINAL (d)       |     0/12 (0%)    1/14 (7%)    0/9 (0%)     0/6 (0%)    |0/26 (0%)    0/31 (0%)    0/15 (0%)    0/14 (0%)    |
|FIRST INCIDENCE    |     ---          533          666          ---         |533          674          ---          ---          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.607      P=0.267      P=0.500      (e)         |P=0.095N     P=0.499N     P=0.286N     P=0.332N     |
|POLY 3             |     P=0.610N     P=0.263      P=0.504      (e)         |P=0.087N     P=0.502N     P=0.278N     P=0.306N     |
|POLY 1.5           |     P=0.595N     P=0.253      P=0.504      (e)         |P=0.077N     P=0.504N     P=0.260N     P=0.288N     |
|POLY 6             |     P=0.622      P=0.277      P=0.504      (e)         |P=0.100N     P=0.496N     P=0.303N     P=0.326N     |
|LOGISTIC REGRESSION|     P=0.532N     P=0.224      P=0.502      (e)         |P=0.048N*    P=0.489N     P=0.209N     P=0.203N     |
|COCH-ARM / FISHERS |     P=0.500N     P=0.247      P=0.500      (e)         |P=0.059N     P=0.500N     P=0.247N     P=0.247N     |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      250 PPB      500 PPB      750 PPB     |CONTROL      250 PPB      500 PPB      750 PPB      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Skin                                                                                                                             |
|     Keratoacanthoma                                                                                                             |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     1/50 (2%)    5/50 (10%)   2/50 (4%)    1/50 (2%)   |2/50 (4%)    0/50 (0%)    0/50 (0%)    0/50 (0%)    |
|POLY-3 ADJUSTED (b)|     2.8%         12.7%        5.6%         3.5%        |4.8%         0.0%         0.0%         0.0%         |
|TERMINAL (d)       |     0/12 (0%)    2/14 (14%)   0/9 (0%)     0/6 (0%)    |1/26 (4%)    0/31 (0%)    0/15 (0%)    0/14 (0%)    |
|FIRST INCIDENCE    |     652          638          666          502         |682          ---          ---          ---          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.552N     P=0.163      P=0.498      P=0.692     |P=0.094N     P=0.214N     P=0.355N     P=0.357N     |
|POLY 3             |     P=0.502N     P=0.126      P=0.505      P=0.709     |P=0.068N     P=0.236N     P=0.274N     P=0.302N     |
|POLY 1.5           |     P=0.487N     P=0.116      P=0.505      P=0.715     |P=0.063N     P=0.238N     P=0.258N     P=0.285N     |
|POLY 6             |     P=0.517N     P=0.139      P=0.501      P=0.705     |P=0.074N     P=0.230N     P=0.296N     P=0.319N     |
|LOGISTIC REGRESSION|     P=0.470N     P=0.131      P=0.502      P=0.771N    |P=0.075N     P=0.233N     P=0.292N     P=0.310N     |
|COCH-ARM / FISHERS |     P=0.380N     P=0.102      P=0.500      P=0.753N    |P=0.056N     P=0.247N     P=0.247N     P=0.247N     |
|=================================================================================================================================|
       Date:  09/14/98                           EXPERIMENT: 05184 TEST: 05                                            Page 15
                     Statistical Analysis of Primary Tumors in Rats(FISCHER 344)       -                   GLUTARALDEHYDE
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      250 PPB      500 PPB      750 PPB     |CONTROL      250 PPB      500 PPB      750 PPB      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Skin                                                                                                                             |
|     Squamous Cell Papilloma, Papilloma, Squamous Cell                                                                           |
|     Carcinoma or Keratoacanthoma                                                                                                |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     1/50 (2%)    5/50 (10%)   3/50 (6%)    3/50 (6%)   |3/50 (6%)    1/50 (2%)    1/50 (2%)    0/50 (0%)    |
|POLY-3 ADJUSTED (b)|     2.8%         12.7%        8.3%         10.5%       |7.1%         2.4%         2.8%         0.0%         |
|TERMINAL (d)       |     0/12 (0%)    2/14 (14%)   0/9 (0%)     1/6 (17%)   |1/26 (4%)    1/31 (3%)    1/15 (7%)    0/14 (0%)    |
|FIRST INCIDENCE    |     652          638          617          502         |680          730 (T)      730 (T)      ---          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.173      P=0.163      P=0.315      P=0.181     |P=0.130N     P=0.272N     P=0.497N     P=0.221N     |
|POLY 3             |     P=0.252      P=0.126      P=0.312      P=0.231     |P=0.085N     P=0.305N     P=0.366N     P=0.176N     |
|POLY 1.5           |     P=0.262      P=0.116      P=0.312      P=0.239     |P=0.074N     P=0.308N     P=0.339N     P=0.160N     |
|POLY 6             |     P=0.245      P=0.139      P=0.311      P=0.226     |P=0.099N     P=0.297N     P=0.402N     P=0.193N     |
|LOGISTIC REGRESSION|     P=0.243      P=0.131      P=0.309      P=0.248     |P=0.091N     P=0.299N     P=0.396N     P=0.172N     |
|COCH-ARM / FISHERS |     P=0.345      P=0.102      P=0.309      P=0.309     |P=0.053N     P=0.309N     P=0.309N     P=0.121N     |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      250 PPB      500 PPB      750 PPB     |CONTROL      250 PPB      500 PPB      750 PPB      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Skin                                                                                                                             |
|     Squamous Cell Papilloma, Papilloma, or Keratoacanthoma                                                                      |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     1/50 (2%)    5/50 (10%)   3/50 (6%)    2/50 (4%)   |2/50 (4%)    1/50 (2%)    1/50 (2%)    0/50 (0%)    |
|POLY-3 ADJUSTED (b)|     2.8%         12.7%        8.3%         7.1%        |4.8%         2.4%         2.8%         0.0%         |
|TERMINAL (d)       |     0/12 (0%)    2/14 (14%)   0/9 (0%)     1/6 (17%)   |1/26 (4%)    1/31 (3%)    1/15 (7%)    0/14 (0%)    |
|FIRST INCIDENCE    |     652          638          617          502         |682          730 (T)      730 (T)      ---          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.303      P=0.163      P=0.315      P=0.354     |P=0.255N     P=0.453N     P=0.676N     P=0.357N     |
|POLY 3             |     P=0.384      P=0.126      P=0.312      P=0.422     |P=0.192N     P=0.498N     P=0.555N     P=0.302N     |
|POLY 1.5           |     P=0.397      P=0.116      P=0.312      P=0.431     |P=0.174N     P=0.502N     P=0.531N     P=0.285N     |
|POLY 6             |     P=0.372      P=0.139      P=0.311      P=0.415     |P=0.214N     P=0.490N     P=0.586N     P=0.319N     |
|LOGISTIC REGRESSION|     P=0.391      P=0.131      P=0.309      P=0.450     |P=0.206N     P=0.486N     P=0.610N     P=0.310N     |
|COCH-ARM / FISHERS |     P=0.500      P=0.102      P=0.309      P=0.500     |P=0.129N     P=0.500N     P=0.500N     P=0.247N     |
|=================================================================================================================================|
       Date:  09/14/98                           EXPERIMENT: 05184 TEST: 05                                            Page 16
                     Statistical Analysis of Primary Tumors in Rats(FISCHER 344)       -                   GLUTARALDEHYDE
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      250 PPB      500 PPB      750 PPB     |CONTROL      250 PPB      500 PPB      750 PPB      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Testes                                                                                                                           |
|     Adenoma                                                                                                                     |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     36/50 (72%)  44/50 (88%)  40/50 (80%)  31/50 (62%) |                                                    |
|POLY-3 ADJUSTED (b)|     85.9%        92.2%        88.1%        87.4%       |                                                    |
|TERMINAL (d)       |     12/12 (100%) 13/14 (93%)  9/9 (100%)   6/6 (100%)  |                                                    |
|FIRST INCIDENCE    |     495          356          365          449         |                                                    |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.093      P=0.499      P=0.174      P=0.164     |                                                    |
|POLY 3             |     P=0.553      P=0.219      P=0.507      P=0.571     |                                                    |
|POLY 1.5           |     P=0.547      P=0.109      P=0.383      P=0.554     |                                                    |
|POLY 6             |     P=0.534N     P=0.548      P=0.695N     P=0.735     |                                                    |
|LOGISTIC REGRESSION|     P=0.304      P=0.119      P=0.269      P=0.288     |                                                    |
|COCH-ARM / FISHERS |     P=0.093N     P=0.039 *    P=0.241      P=0.198N    |                                                    |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      250 PPB      500 PPB      750 PPB     |CONTROL      250 PPB      500 PPB      750 PPB      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Thyroid Gland: C-Cell                                                                                                            |
|     Adenoma                                                                                                                     |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     1/50 (2%)    4/50 (8%)    2/50 (4%)    2/50 (4%)   |2/50 (4%)    1/50 (2%)    2/49 (4%)    0/49 (0%)    |
|POLY-3 ADJUSTED (b)|     2.9%         10.2%        5.5%         7.1%        |4.8%         2.4%         5.7%         0.0%         |
|TERMINAL (d)       |     1/12 (8%)    0/14 (0%)    0/9 (0%)     0/6 (0%)    |2/26 (8%)    1/31 (3%)    2/15 (13%)   0/14 (0%)    |
|FIRST INCIDENCE    |     729 (T)      615          638          564         |730 (T)      730 (T)      730 (T)      ---          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.351      P=0.264      P=0.488      P=0.365     |P=0.415N     P=0.438N     P=0.484      P=0.382N     |
|POLY 3             |     P=0.419      P=0.214      P=0.511      P=0.426     |P=0.312N     P=0.497N     P=0.629      P=0.303N     |
|POLY 1.5           |     P=0.425      P=0.200      P=0.508      P=0.432     |P=0.287N     P=0.501N     P=0.654      P=0.288N     |
|POLY 6             |     P=0.418      P=0.236      P=0.514      P=0.425     |P=0.338N     P=0.487N     P=0.596      P=0.317N     |
|LOGISTIC REGRESSION|     P=0.406      P=0.222      P=0.503      P=0.426     |P=0.415N     P=0.438N     P=0.484      (e)          |
|COCH-ARM / FISHERS |     P=0.500      P=0.181      P=0.500      P=0.500     |P=0.215N     P=0.500N     P=0.684      P=0.253N     |
|=================================================================================================================================|
       Date:  09/14/98                           EXPERIMENT: 05184 TEST: 05                                            Page 17
                     Statistical Analysis of Primary Tumors in Rats(FISCHER 344)       -                   GLUTARALDEHYDE
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      250 PPB      500 PPB      750 PPB     |CONTROL      250 PPB      500 PPB      750 PPB      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Thyroid Gland: C-Cell                                                                                                            |
|     Carcinoma                                                                                                                   |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     0/50 (0%)    1/50 (2%)    0/50 (0%)    0/50 (0%)   |0/50 (0%)    2/50 (4%)    0/49 (0%)    0/49 (0%)    |
|POLY-3 ADJUSTED (b)|     0.0%         2.6%         0.0%         0.0%        |0.0%         4.8%         0.0%         0.0%         |
|TERMINAL (d)       |     0/12 (0%)    1/14 (7%)    0/9 (0%)     0/6 (0%)    |0/26 (0%)    2/31 (7%)    0/15 (0%)    0/14 (0%)    |
|FIRST INCIDENCE    |     ---          729 (T)      ---          ---         |---          730 (T)      ---          ---          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.608N     P=0.531      (e)          (e)         |P=0.528N     P=0.277      (e)          (e)          |
|POLY 3             |     P=0.563N     P=0.520      (e)          (e)         |P=0.487N     P=0.239      (e)          (e)          |
|POLY 1.5           |     P=0.555N     P=0.512      (e)          (e)         |P=0.456N     P=0.236      (e)          (e)          |
|POLY 6             |     P=0.571N     P=0.530      (e)          (e)         |P=0.522N     P=0.245      (e)          (e)          |
|LOGISTIC REGRESSION|     (e)          P=0.531      (e)          (e)         |(e)          P=0.277      (e)          (e)          |
|COCH-ARM / FISHERS |     P=0.500N     P=0.500      (e)          (e)         |P=0.380N     P=0.247      (e)          (e)          |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      250 PPB      500 PPB      750 PPB     |CONTROL      250 PPB      500 PPB      750 PPB      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Thyroid Gland: C-Cell                                                                                                            |
|     Carcinoma or Adenoma                                                                                                        |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     1/50 (2%)    5/50 (10%)   2/50 (4%)    2/50 (4%)   |2/50 (4%)    3/50 (6%)    2/49 (4%)    0/49 (0%)    |
|POLY-3 ADJUSTED (b)|     2.9%         12.7%        5.5%         7.1%        |4.8%         7.1%         5.7%         0.0%         |
|TERMINAL (d)       |     1/12 (8%)    1/14 (7%)    0/9 (0%)     0/6 (0%)    |2/26 (8%)    3/31 (10%)   2/15 (13%)   0/14 (0%)    |
|FIRST INCIDENCE    |     729 (T)      615          638          564         |730 (T)      730 (T)      730 (T)      ---          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.382      P=0.168      P=0.488      P=0.365     |P=0.370N     P=0.581      P=0.484      P=0.382N     |
|POLY 3             |     P=0.471      P=0.128      P=0.511      P=0.426     |P=0.264N     P=0.504      P=0.629      P=0.303N     |
|POLY 1.5           |     P=0.477      P=0.117      P=0.508      P=0.432     |P=0.234N     P=0.498      P=0.654      P=0.288N     |
|POLY 6             |     P=0.472      P=0.145      P=0.514      P=0.425     |P=0.298N     P=0.517      P=0.596      P=0.317N     |
|LOGISTIC REGRESSION|     P=0.451      P=0.140      P=0.503      P=0.426     |P=0.370N     P=0.581      P=0.484      (e)          |
|COCH-ARM / FISHERS |     P=0.558      P=0.102      P=0.500      P=0.500     |P=0.157N     P=0.500      P=0.684      P=0.253N     |
|=================================================================================================================================|
       Date:  09/14/98                           EXPERIMENT: 05184 TEST: 05                                            Page 18
                     Statistical Analysis of Primary Tumors in Rats(FISCHER 344)       -                   GLUTARALDEHYDE
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      250 PPB      500 PPB      750 PPB     |CONTROL      250 PPB      500 PPB      750 PPB      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Thyroid Gland: Follicular Cell                                                                                                   |
|     Adenoma                                                                                                                     |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     1/50 (2%)    0/50 (0%)    0/50 (0%)    0/50 (0%)   |0/50 (0%)    0/50 (0%)    0/49 (0%)    2/49 (4%)    |
|POLY-3 ADJUSTED (b)|     2.8%         0.0%         0.0%         0.0%        |0.0%         0.0%         0.0%         6.2%         |
|TERMINAL (d)       |     0/12 (0%)    0/14 (0%)    0/9 (0%)     0/6 (0%)    |0/26 (0%)    0/31 (0%)    0/15 (0%)    0/14 (0%)    |
|FIRST INCIDENCE    |     638          ---          ---          ---         |---          ---          ---          654          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.194N     P=0.461N     P=0.480N     P=0.548N    |P=0.034 *    (e)          (e)          P=0.165      |
|POLY 3             |     P=0.212N     P=0.482N     P=0.499N     P=0.549N    |P=0.055      (e)          (e)          P=0.184      |
|POLY 1.5           |     P=0.206N     P=0.488N     P=0.498N     P=0.542N    |P=0.056      (e)          (e)          P=0.194      |
|POLY 6             |     P=0.217N     P=0.474N     P=0.503N     P=0.556N    |P=0.051      (e)          (e)          P=0.176      |
|LOGISTIC REGRESSION|     P=0.188N     P=0.505N     P=0.500N     P=0.534N    |P=0.043 *    (e)          (e)          P=0.196      |
|COCH-ARM / FISHERS |     P=0.185N     P=0.500N     P=0.500N     P=0.500N    |P=0.055      (e)          (e)          P=0.242      |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      250 PPB      500 PPB      750 PPB     |CONTROL      250 PPB      500 PPB      750 PPB      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Thyroid Gland: Follicular Cell                                                                                                   |
|     Carcinoma or Adenoma                                                                                                        |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     1/50 (2%)    1/50 (2%)    0/50 (0%)    0/50 (0%)   |0/50 (0%)    0/50 (0%)    0/49 (0%)    2/49 (4%)    |
|POLY-3 ADJUSTED (b)|     2.8%         2.6%         0.0%         0.0%        |0.0%         0.0%         0.0%         6.2%         |
|TERMINAL (d)       |     0/12 (0%)    0/14 (0%)    0/9 (0%)     0/6 (0%)    |0/26 (0%)    0/31 (0%)    0/15 (0%)    0/14 (0%)    |
|FIRST INCIDENCE    |     638          675          ---          ---         |---          ---          ---          654          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.199N     P=0.721N     P=0.480N     P=0.548N    |P=0.034 *    (e)          (e)          P=0.165      |
|POLY 3             |     P=0.208N     P=0.740N     P=0.499N     P=0.549N    |P=0.055      (e)          (e)          P=0.184      |
|POLY 1.5           |     P=0.201N     P=0.747N     P=0.498N     P=0.542N    |P=0.056      (e)          (e)          P=0.194      |
|POLY 6             |     P=0.216N     P=0.730N     P=0.503N     P=0.556N    |P=0.051      (e)          (e)          P=0.176      |
|LOGISTIC REGRESSION|     P=0.186N     P=0.757N     P=0.500N     P=0.534N    |P=0.043 *    (e)          (e)          P=0.196      |
|COCH-ARM / FISHERS |     P=0.170N     P=0.753N     P=0.500N     P=0.500N    |P=0.055      (e)          (e)          P=0.242      |
|=================================================================================================================================|
       Date:  09/14/98                           EXPERIMENT: 05184 TEST: 05                                            Page 19
                     Statistical Analysis of Primary Tumors in Rats(FISCHER 344)       -                   GLUTARALDEHYDE
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      250 PPB      500 PPB      750 PPB     |CONTROL      250 PPB      500 PPB      750 PPB      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Uterus                                                                                                                           |
|     Polyp Stromal                                                                                                               |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |                                                        |8/50 (16%)   10/50 (20%)  8/50 (16%)   3/50 (6%)    |
|POLY-3 ADJUSTED (b)|                                                        |18.6%        23.1%        21.1%        9.3%         |
|TERMINAL (d)       |                                                        |3/26 (12%)   6/31 (19%)   2/15 (13%)   1/14 (7%)    |
|FIRST INCIDENCE    |                                                        |566          612          455          641          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |                                                        |P=0.397N     P=0.504      P=0.310      P=0.315N     |
|POLY 3             |                                                        |P=0.239N     P=0.400      P=0.499      P=0.215N     |
|POLY 1.5           |                                                        |P=0.181N     P=0.391      P=0.547      P=0.180N     |
|POLY 6             |                                                        |P=0.313N     P=0.423      P=0.437      P=0.253N     |
|LOGISTIC REGRESSION|                                                        |P=0.145N     P=0.396      P=0.592      P=0.185N     |
|COCH-ARM / FISHERS |                                                        |P=0.075N     P=0.398      P=0.607N     P=0.100N     |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      250 PPB      500 PPB      750 PPB     |CONTROL      250 PPB      500 PPB      750 PPB      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Uterus                                                                                                                           |
|     Sarcoma Stromal or Polyp Stromal                                                                                            |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |                                                        |8/50 (16%)   10/50 (20%)  8/50 (16%)   3/50 (6%)    |
|POLY-3 ADJUSTED (b)|                                                        |18.6%        23.1%        21.1%        9.3%         |
|TERMINAL (d)       |                                                        |3/26 (12%)   6/31 (19%)   2/15 (13%)   1/14 (7%)    |
|FIRST INCIDENCE    |                                                        |566          612          455          641          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |                                                        |P=0.397N     P=0.504      P=0.310      P=0.315N     |
|POLY 3             |                                                        |P=0.239N     P=0.400      P=0.499      P=0.215N     |
|POLY 1.5           |                                                        |P=0.181N     P=0.391      P=0.547      P=0.180N     |
|POLY 6             |                                                        |P=0.313N     P=0.423      P=0.437      P=0.253N     |
|LOGISTIC REGRESSION|                                                        |P=0.145N     P=0.396      P=0.592      P=0.185N     |
|COCH-ARM / FISHERS |                                                        |P=0.075N     P=0.398      P=0.607N     P=0.100N     |
|=================================================================================================================================|
       Date:  09/14/98                           EXPERIMENT: 05184 TEST: 05                                            Page 20
                     Statistical Analysis of Primary Tumors in Rats(FISCHER 344)       -                   GLUTARALDEHYDE
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      250 PPB      500 PPB      750 PPB     |CONTROL      250 PPB      500 PPB      750 PPB      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Zymbal's Gland                                                                                                                   |
|     Carcinoma                                                                                                                   |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     1/50 (2%)    2/50 (4%)    1/50 (2%)    0/50 (0%)   |0/50 (0%)    0/50 (0%)    1/50 (2%)    0/50 (0%)    |
|POLY-3 ADJUSTED (b)|     2.8%         5.1%         2.8%         0.0%        |0.0%         0.0%         2.8%         0.0%         |
|TERMINAL (d)       |     0/12 (0%)    1/14 (7%)    0/9 (0%)     0/6 (0%)    |0/26 (0%)    0/31 (0%)    1/15 (7%)    0/14 (0%)    |
|FIRST INCIDENCE    |     652          652          581          ---         |---          ---          730 (T)      ---          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.335N     P=0.557      P=0.747N     P=0.570N    |P=0.386      (e)          P=0.390      (e)          |
|POLY 3             |     P=0.339N     P=0.534      P=0.757N     P=0.549N    |P=0.449      (e)          P=0.469      (e)          |
|POLY 1.5           |     P=0.324N     P=0.522      P=0.757N     P=0.542N    |P=0.458      (e)          P=0.482      (e)          |
|POLY 6             |     P=0.354N     P=0.551      P=0.760N     P=0.556N    |P=0.445      (e)          P=0.452      (e)          |
|LOGISTIC REGRESSION|     P=0.282N     P=0.535      P=0.759      P=0.541N    |(e)          (e)          P=0.390      (e)          |
|COCH-ARM / FISHERS |     P=0.249N     P=0.500      P=0.753N     P=0.500N    |P=0.500      (e)          P=0.500      (e)          |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      250 PPB      500 PPB      750 PPB     |CONTROL      250 PPB      500 PPB      750 PPB      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Zymbal's Gland                                                                                                                   |
|     Carcinoma or Adenoma                                                                                                        |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     1/50 (2%)    3/50 (6%)    1/50 (2%)    0/50 (0%)   |0/50 (0%)    0/50 (0%)    1/50 (2%)    0/50 (0%)    |
|POLY-3 ADJUSTED (b)|     2.8%         7.7%         2.8%         0.0%        |0.0%         0.0%         2.8%         0.0%         |
|TERMINAL (d)       |     0/12 (0%)    1/14 (7%)    0/9 (0%)     0/6 (0%)    |0/26 (0%)    0/31 (0%)    1/15 (7%)    0/14 (0%)    |
|FIRST INCIDENCE    |     652          652          581          ---         |---          ---          730 (T)      ---          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.298N     P=0.367      P=0.747N     P=0.570N    |P=0.386      (e)          P=0.390      (e)          |
|POLY 3             |     P=0.296N     P=0.342      P=0.757N     P=0.549N    |P=0.449      (e)          P=0.469      (e)          |
|POLY 1.5           |     P=0.282N     P=0.328      P=0.757N     P=0.542N    |P=0.458      (e)          P=0.482      (e)          |
|POLY 6             |     P=0.310N     P=0.362      P=0.760N     P=0.556N    |P=0.445      (e)          P=0.452      (e)          |
|LOGISTIC REGRESSION|     P=0.246N     P=0.340      P=0.759      P=0.541N    |(e)          (e)          P=0.390      (e)          |
|COCH-ARM / FISHERS |     P=0.209N     P=0.309      P=0.753N     P=0.500N    |P=0.500      (e)          P=0.500      (e)          |
|=================================================================================================================================|
       Date:  09/14/98                           EXPERIMENT: 05184 TEST: 05                                            Page 21
                     Statistical Analysis of Primary Tumors in Rats(FISCHER 344)       -                   GLUTARALDEHYDE
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      250 PPB      500 PPB      750 PPB     |CONTROL      250 PPB      500 PPB      750 PPB      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|All Organs                                                                                                                       |
|     Leukemia: Lymphocytic, Monocytic, Mononuclear, or                                                                           |
|     Undifferentiated                                                                                                            |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     21/50 (42%)  24/50 (48%)  25/50 (50%)  16/50 (32%) |18/50 (36%)  20/50 (40%)  25/50 (50%)  12/50 (24%)  |
|POLY-3 ADJUSTED (b)|     51.4%        53.2%        58.6%        50.5%       |39.7%        45.2%        57.5%        34.4%        |
|TERMINAL (d)       |     5/12 (42%)   4/14 (29%)   3/9 (33%)    1/6 (17%)   |7/26 (27%)   11/31 (36%)  4/15 (27%)   3/14 (21%)   |
|FIRST INCIDENCE    |     495          449          481          449         |533          542          355          514          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.312      P=0.507N     P=0.263      P=0.501     |P=0.154      P=0.559N     P=0.018 *    P=0.537      |
|POLY 3             |     P=0.439      P=0.522      P=0.324      P=0.566N    |P=0.410      P=0.375      P=0.065      P=0.401N     |
|POLY 1.5           |     P=0.505      P=0.456      P=0.309      P=0.500N    |P=0.521      P=0.381      P=0.083      P=0.326N     |
|POLY 6             |     P=0.389      P=0.586N     P=0.347      P=0.587     |P=0.314      P=0.381      P=0.050      P=0.470N     |
|LOGISTIC REGRESSION|     P=0.428N     P=0.353      P=0.285      P=0.474N    |P=0.369N     P=0.414      P=0.135      P=0.264N     |
|COCH-ARM / FISHERS |     P=0.203N     P=0.344      P=0.274      P=0.204N    |P=0.217N     P=0.418      P=0.113      P=0.138N     |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      250 PPB      500 PPB      750 PPB     |CONTROL      250 PPB      500 PPB      750 PPB      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|All Organs                                                                                                                       |
|     Mesothelioma: Benign, Malignant, NOS                                                                                        |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     2/50 (4%)    1/50 (2%)    0/50 (0%)    1/50 (2%)   |0/50 (0%)    0/50 (0%)    0/50 (0%)    0/50 (0%)    |
|POLY-3 ADJUSTED (b)|     5.6%         2.6%         0.0%         3.6%        |0.0%         0.0%         0.0%         0.0%         |
|TERMINAL (d)       |     0/12 (0%)    1/14 (7%)    0/9 (0%)     0/6 (0%)    |0/26 (0%)    0/31 (0%)    0/15 (0%)    0/14 (0%)    |
|FIRST INCIDENCE    |     638          729 (T)      ---          666         |---          ---          ---          ---          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.340N     P=0.446N     P=0.233N     P=0.597N    |(e)          (e)          (e)          (e)          |
|POLY 3             |     P=0.278N     P=0.470N     P=0.236N     P=0.585N    |(e)          (e)          (e)          (e)          |
|POLY 1.5           |     P=0.273N     P=0.481N     P=0.235N     P=0.573N    |(e)          (e)          (e)          (e)          |
|POLY 6             |     P=0.286N     P=0.459N     P=0.241N     P=0.597N    |(e)          (e)          (e)          (e)          |
|LOGISTIC REGRESSION|     P=0.300N     P=0.461N     P=0.235N     P=0.578N    |(e)          (e)          (e)          (e)          |
|COCH-ARM / FISHERS |     P=0.249N     P=0.500N     P=0.247N     P=0.500N    |(e)          (e)          (e)          (e)          |
|=================================================================================================================================|
       Date:  09/14/98                           EXPERIMENT: 05184 TEST: 05                                            Page 22
                     Statistical Analysis of Primary Tumors in Rats(FISCHER 344)       -                   GLUTARALDEHYDE
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      250 PPB      500 PPB      750 PPB     |CONTROL      250 PPB      500 PPB      750 PPB      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|All Organs                                                                                                                       |
|     Mesothelioma: Malignant                                                                                                     |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     2/50 (4%)    1/50 (2%)    0/50 (0%)    1/50 (2%)   |0/50 (0%)    0/50 (0%)    0/50 (0%)    0/50 (0%)    |
|POLY-3 ADJUSTED (b)|     5.6%         2.6%         0.0%         3.6%        |0.0%         0.0%         0.0%         0.0%         |
|TERMINAL (d)       |     0/12 (0%)    1/14 (7%)    0/9 (0%)     0/6 (0%)    |0/26 (0%)    0/31 (0%)    0/15 (0%)    0/14 (0%)    |
|FIRST INCIDENCE    |     638          729 (T)      ---          666         |---          ---          ---          ---          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.340N     P=0.446N     P=0.233N     P=0.597N    |(e)          (e)          (e)          (e)          |
|POLY 3             |     P=0.278N     P=0.470N     P=0.236N     P=0.585N    |(e)          (e)          (e)          (e)          |
|POLY 1.5           |     P=0.273N     P=0.481N     P=0.235N     P=0.573N    |(e)          (e)          (e)          (e)          |
|POLY 6             |     P=0.286N     P=0.459N     P=0.241N     P=0.597N    |(e)          (e)          (e)          (e)          |
|LOGISTIC REGRESSION|     P=0.300N     P=0.461N     P=0.235N     P=0.578N    |(e)          (e)          (e)          (e)          |
|COCH-ARM / FISHERS |     P=0.249N     P=0.500N     P=0.247N     P=0.500N    |(e)          (e)          (e)          (e)          |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      250 PPB      500 PPB      750 PPB     |CONTROL      250 PPB      500 PPB      750 PPB      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|All Organs                                                                                                                       |
|     Benign Tumors                                                                                                               |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     48/50 (96%)  48/50 (96%)  50/50 (100%) 38/50 (76%) |42/50 (84%)  43/50 (86%)  40/50 (80%)  31/50 (62%)  |
|POLY-3 ADJUSTED (b)|     98.6%        98.2%        100.0%       97.9%       |90.8%        92.2%        88.8%        80.9%        |
|TERMINAL (d)       |     12/12 (100%) 14/14 (100%) 9/9 (100%)   6/6 (100%)  |25/26 (96%)  29/31 (94%)  14/15 (93%)  10/14 (71%)  |
|FIRST INCIDENCE    |     392          356          365          106         |542          561          455          474          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.140      P=0.197N     P=0.307      P=0.314     |P=0.034 *    P=0.270N     P=0.022 *    P=0.201      |
|POLY 3             |     P=0.625      P=0.811N     P=0.684      P=0.809N    |P=0.079N     P=0.552      P=0.517N     P=0.132N     |
|POLY 1.5           |     P=0.363N     P=0.678N     P=0.553      P=0.347N    |P=0.048N*    P=0.478      P=0.460N     P=0.094N     |
|POLY 6             |     P=0.515      P=0.961      P=0.890      P=0.960     |P=0.100N     P=0.658N     P=0.574N     P=0.142N     |
|LOGISTIC REGRESSION|     P=0.332N     P=0.489N     P=0.376      P=0.345N    |P=0.236N     P=0.430      P=0.433      P=0.332N     |
|COCH-ARM / FISHERS |     P<0.001N**   P=0.691N     P=0.247      P=0.004N**  |P=0.004N**   P=0.500      P=0.398N     P=0.012N*    |
|=================================================================================================================================|
       Date:  09/14/98                           EXPERIMENT: 05184 TEST: 05                                            Page 23
                     Statistical Analysis of Primary Tumors in Rats(FISCHER 344)       -                   GLUTARALDEHYDE
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      250 PPB      500 PPB      750 PPB     |CONTROL      250 PPB      500 PPB      750 PPB      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|All Organs                                                                                                                       |
|     Malignant Tumors                                                                                                            |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     28/50 (56%)  33/50 (66%)  31/50 (62%)  19/50 (38%) |27/50 (54%)  26/50 (52%)  29/50 (58%)  16/50 (32%)  |
|POLY-3 ADJUSTED (b)|     66.5%        71.1%        69.5%        59.0%       |57.8%        56.7%        63.2%        44.1%        |
|TERMINAL (d)       |     6/12 (50%)   7/14 (50%)   3/9 (33%)    2/6 (33%)   |11/26 (42%)  14/31 (45%)  4/15 (27%)   5/14 (36%)   |
|FIRST INCIDENCE    |     495          449          481          449         |518          437          276          463          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.457      P=0.540N     P=0.313      P=0.494N    |P=0.301      P=0.329N     P=0.071      P=0.478N     |
|POLY 3             |     P=0.338N     P=0.401      P=0.471      P=0.328N    |P=0.259N     P=0.541N     P=0.369      P=0.152N     |
|POLY 1.5           |     P=0.269N     P=0.323      P=0.423      P=0.258N    |P=0.175N     P=0.538N     P=0.405      P=0.102N     |
|POLY 6             |     P=0.395N     P=0.496      P=0.535      P=0.400N    |P=0.362N     P=0.536N     P=0.326      P=0.215N     |
|LOGISTIC REGRESSION|     P=0.197N     P=0.272      P=0.365      P=0.260N    |P=0.065N     P=0.505N     P=0.529      P=0.071N     |
|COCH-ARM / FISHERS |     P=0.037N*    P=0.206      P=0.342      P=0.054N    |P=0.033N*    P=0.500N     P=0.420      P=0.021N*    |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      250 PPB      500 PPB      750 PPB     |CONTROL      250 PPB      500 PPB      750 PPB      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|All Organs                                                                                                                       |
|     Malignant and Benign Tumors                                                                                                 |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     49/50 (98%)  50/50 (100%) 50/50 (100%) 38/50 (76%) |49/50 (98%)  46/50 (92%)  49/50 (98%)  36/50 (72%)  |
|POLY-3 ADJUSTED (b)|     100.0%       100.0%       100.0%       97.9%       |100.0%       95.8%        98.0%        89.8%        |
|TERMINAL (d)       |     12/12 (100%) 14/14 (100%) 9/9 (100%)   6/6 (100%)  |26/26 (100%) 29/31 (94%)  14/15 (93%)  12/14 (86%)  |
|FIRST INCIDENCE    |     392          356          365          106         |518          437          276          463          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.185      P=0.231N     P=0.350      P=0.354     |P=0.024 *    P=0.115N     P=0.013 *    P=0.205      |
|POLY 3             |     P=0.115N     P=1.000      P=1.000      P=0.603N    |P=0.026N*    P=0.230N     P=0.506N     P=0.021N*    |
|POLY 1.5           |     P=0.008N**   P=1.000      P=1.000      P=0.085N    |P=0.006N**   P=0.209N     P=0.530N     P=0.005N**   |
|POLY 6             |     P=0.986N     P=1.000      P=1.000      P=1.000N    |P=0.065N     P=0.233N     P=0.504N     P=0.056N     |
|LOGISTIC REGRESSION|     P=0.038N*    (e)          (e)          P=0.163N    |P=0.010N*    P=0.224N     P=0.761      P=0.028N*    |
|COCH-ARM / FISHERS |     P<0.001N**   P=0.500      P=0.500      P<0.001N**  |P<0.001N**   P=0.181N     P=0.753N     P<0.001N**   |
|=================================================================================================================================|

(a)  Number of tumor-bearing animals /  number of animals examined at site.
(b)  Poly-3 adjusted lifetime tumor incidence.
(d)  Observed incidence at terminal kill.
(f)  Beneath the control incidence are the P-values associated with the trend 
test.  Beneath the dosed group incidence are the P-values corresponding to 
pairwise comparisons between the controls and that dosed group.  The life
table analysis regards tumors in animals dying prior to  terminal kill as
 being (directly or indirectly) the cause of death.
Logistic regression is an alternative
 method for analyzing the incidence of non-fatal tumors. The Cochran-Armitage
and Fishers exact tests compare directly the overall incidence rates
For all tests a negative trend is indicated by N
(e)  Value of Statistic cannot be computed.
(I)  Interim sacrifice
(T)  Terminal sacrifice
#   Tumor rates based on number of animals necropsied.
*   To the right of any statistical result, indicates significance at (P<=0.05).
**  To the right of any statistical result, indicates significance at (P<=0.01).