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TDMS Study 05184-05 Pathology Tables

NTP Experiment-Test: 05184-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           GLUTARALDEHYDE                                      Date: 09/14/98
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 08:29:41

                                                         2 YEAR CHRONIC




       Facility:  Battelle Northwest

       Chemical CAS #:  111-30-8

       Lock Date:  07/28/97

       Cage Range:  All

       Reasons For Removal:    All

       Removal Date Range:     All

       Treatment Groups:       Include All




































                                                              Page   1



NTP Experiment-Test: 05184-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           GLUTARALDEHYDE                                      Date: 09/14/98  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 08:29:41  
                                                                                                                                    

 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 5| 6| 7| 5| 7| 5| 7| 5| 7| 5| 5| 7| 7| 1| 7|             
                             DAY ON TEST   | 3| 3| 0| 0| 3| 3| 3| 3| 3| 9| 9| 9| 3| 8| 3| 3| 3| 1| 3| 8| 6| 3| 3| 1| 3|             
                                           | 1| 1| 8| 3| 1| 0| 1| 1| 1| 4| 8| 8| 0| 9| 1| 3| 0| 8| 0| 9| 6| 1| 1| 9| 1|             

 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    CONTROL                                | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             

 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +|             
      Parasite Metazoan                    |                                                                         2|             

                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +|             
      Parasite Metazoan                    |                                     1                                    |             

                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +|             
      Parasite Metazoan                    |             1     1                                            1         |             

                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +|             

                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +|             

                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +|             

                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                                                          |             
      Basophilic Focus                     |                                                                          |             
      Basophilic Focus, Multiple           |                                                                          |             
      Clear Cell Focus                     |                                  X                                       |             
      Hematopoietic Cell Proliferation     |                                                    1                     |             
      Hepatodiaphragmatic Nodule           |                X                                                     X   |             
      Necrosis                             |                                                                          |             
      Vacuolization Cytoplasmic            |                            4                    4                       2|             

                                            __________________________________________________________________________|             
   Mesentery                               |    +              +                             +  +                     |             
      Fat, Necrosis                        |    2              2                             3                        |             

                                            __________________________________________________________________________|             
   Oral Mucosa                             |                                                                          |             

                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Acinus, Atrophy                      |       2                                                        3         |             

                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                                                                          |             

                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Suppurative            |                            3     2                                       |             
      Ulcer                                |                            4  4                                          |             
      Epithelium, Hyperplasia              |                            3                                             |             

                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

                                            __________________________________________________________________________|             
   Tongue                                  |                                  +                                       |             

                                            __________________________________________________________________________|             
   Tooth                                   |                                                                      +   |             
      Degeneration                         |                                                                      4   |             

 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Blood Vessel                            | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation                         |                                  4                                       |             

                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrium, Thrombosis                   |                                                                          |             
      Myocardium, Fibrosis                 |                                                                          |             

 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

 _____________________________________________________________________________________________________________________|             
NTP Experiment-Test: 05184-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           GLUTARALDEHYDE                                      Date: 09/14/98  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 08:29:41  
                                                                                                                                    

 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 5| 6| 7| 5| 7| 5| 7| 5| 7| 5| 5| 7| 7| 1| 7|             
                             DAY ON TEST   | 3| 3| 0| 0| 3| 3| 3| 3| 3| 9| 9| 9| 3| 8| 3| 3| 3| 1| 3| 8| 6| 3| 3| 1| 3|             
                                           | 1| 1| 8| 3| 1| 0| 1| 1| 1| 4| 8| 8| 0| 9| 1| 3| 0| 8| 0| 9| 6| 1| 1| 9| 1|             

 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    CONTROL                                | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             

 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
      Fibrosis                             |                                                                          |             
      Hematopoietic Cell Proliferation     |                                                    2                     |             
      Vacuolization Cytoplasmic            | 3                          3           1                                 |             

                                            __________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                                                          |             

                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                                                          |             

                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +|             

                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                         4                                                |             
      Hemorrhage                           |                                                             4            |             
      Pars Distalis, Hyperplasia           |                               2                 3                        |             

                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      C-Cell, Hyperplasia                  |    1                                                                     |             

 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Tissue NOS                              |                                                                          |             

 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Clitoral Gland                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                                                          |             
      Hyperplasia                          |                                                                          |             
      Inflammation, Suppurative            |                                           4                              |             

                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                                                          |             
      Bilateral, Cyst                      |                                                                          |             

                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |                                                                4         |             

                                            __________________________________________________________________________|             
   Vagina                                  |                                                                          |             
      Inflammation                         |                                                                          |             

 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

                                            __________________________________________________________________________|             
   Lymph Node                              |                                                                          |             

                                            __________________________________________________________________________|             
   Lymph Node, Bronchial                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +|             

                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +|             

                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Infiltration Cellular, Histiocyte    |                               3                                          |             

                                            __________________________________________________________________________|             
   Lymph Node, Mediastinal                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrosis                             |       3                 3           3                                    |             
      Hematopoietic Cell Proliferation     |                         4                          4                     |             
      Hemorrhage                           |                                                                          |             

                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

 _____________________________________________________________________________________________________________________|             
NTP Experiment-Test: 05184-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           GLUTARALDEHYDE                                      Date: 09/14/98  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 08:29:41  
                                                                                                                                    

 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 5| 6| 7| 5| 7| 5| 7| 5| 7| 5| 5| 7| 7| 1| 7|             
                             DAY ON TEST   | 3| 3| 0| 0| 3| 3| 3| 3| 3| 9| 9| 9| 3| 8| 3| 3| 3| 1| 3| 8| 6| 3| 3| 1| 3|             
                                           | 1| 1| 8| 3| 1| 0| 1| 1| 1| 4| 8| 8| 0| 9| 1| 3| 0| 8| 0| 9| 6| 1| 1| 9| 1|             

 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    CONTROL                                | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             

 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             

 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Galactocele                          |       4                                                                  |             
      Metaplasia, Squamous                 |       4                                                                  |             

                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst Epithelial Inclusion            |                                                                          |             
      Hyperkeratosis                       |                                                       3                  |             
      Subcutaneous Tissue, Inflammation    |                                                                          |             

 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

                                            __________________________________________________________________________|             
   Skeletal Muscle                         |                                                                          |             

 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |                                     2                       2            |             
      Hydrocephalus                        |       2                    2     2  2  3                                 |             

                                            __________________________________________________________________________|             
   Spinal Cord                             |                                                                      +   |             
      Neuron, Degeneration                 |                                                                      2   |             

 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Larynx                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Foreign Body                         |       X                                                        X         |             
      Epiglottis, Inflammation, Suppurative|                                                                4         |             
      Glands, Inflammation                 |    1  1  1  1           1  1  3                       2        4  1      |             
      Squamous Epithelium, Hyperplasia     |                               3                                3         |             

                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |                                                                          |             
      Inflammation, Chronic                |                               4                                          |             
      Necrosis                             |                                                                          |             
      Alveolar Epithelium, Hyperplasia     |    1        1     1     2                                                |             
      Alveolus, Hemorrhage                 |                                                                          |             
      Alveolus, Infiltration Cellular,     |                                                                          |             
           Histiocyte                      | 3  1  2     1     1     3  1  4     1     1     2     1     3  1         |             
      Alveolus, Inflammation, Suppurative  | 2                       1                                                |             
      Interstitium, Fibrosis               | 3  1  1                             1           2           2            |             

                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Concretion                           |                                                    2                     |             
      Foreign Body                         |                   X                                                      |             
      Goblet Cell, Respiratory Epithelium, |                                                                          |             
           Hyperplasia                     |                                                                          |             
      Nasolacrimal Duct, Inflammation      |                               3                          2               |             
      Olfactory Epithelium, Degeneration,  |                                                                          |             

 _____________________________________________________________________________________________________________________|             
NTP Experiment-Test: 05184-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           GLUTARALDEHYDE                                      Date: 09/14/98  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 08:29:41  
                                                                                                                                    

 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 5| 6| 7| 5| 7| 5| 7| 5| 7| 5| 5| 7| 7| 1| 7|             
                             DAY ON TEST   | 3| 3| 0| 0| 3| 3| 3| 3| 3| 9| 9| 9| 3| 8| 3| 3| 3| 1| 3| 8| 6| 3| 3| 1| 3|             
                                           | 1| 1| 8| 3| 1| 0| 1| 1| 1| 4| 8| 8| 0| 9| 1| 3| 0| 8| 0| 9| 6| 1| 1| 9| 1|             

 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    CONTROL                                | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             

 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
           Hyaline                         |       1                                               1                  |             
      Respiratory Epithelium, Hyperplasia  |                                                                          |             
      Respiratory Epithelium, Inflammation |                                                             2            |             
      Respiratory Epithelium, Metaplasia,  |                                                                          |             
           Squamous                        |                                                                          |             
      Squamous Epithelium, Hyperplasia     |             1                 1                                          |             
      Squamous Epithelium, Inflammation    |                               2                             3            |             

                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Eye                                     |                                                          +              +|             
      Cataract                             |                                                                         3|             
      Degeneration                         |                                                          4               |             

 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Mineralization                       | 1                                                                        |             
      Nephropathy, Chronic                 | 2  3  2     1     1  2  1  3     3  3  1  1     1     2     2  2  1     1|             
      Pelvis, Dilatation                   |                                                                          |             

                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

 _____________________________________________________________________________________________________________________|             
NTP Experiment-Test: 05184-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           GLUTARALDEHYDE                                      Date: 09/14/98  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 08:29:41  
                                                                                                                                    

 __________________________________________________________________________________________________________________________________ 
                                           | 6| 6| 6| 7| 6| 7| 7| 7| 7| 7| 6| 5| 5| 7| 7| 7| 7| 7| 6| 7| 6| 6| 7| 5| 7|            |
                             DAY ON TEST   | 6| 8| 8| 3| 5| 3| 3| 3| 2| 3| 6| 5| 8| 3| 3| 3| 3| 1| 7| 3| 8| 3| 3| 4| 3|            |
                                           | 0| 2| 0| 1| 1| 1| 1| 1| 2| 1| 6| 0| 9| 0| 0| 0| 1| 2| 4| 1| 0| 8| 1| 2| 0|      T (*) |

 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|      A     |
    CONTROL                                | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |

 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |

                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +|  48        |
      Parasite Metazoan                    |                                                          2               |      2  2.0|

                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +|  48        |
      Parasite Metazoan                    |                                        1                       1         |      3  1.0|

                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +|  48        |
      Parasite Metazoan                    |                1           1                                             |      5  1.0|

                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +|  48        |

                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +|  48        |

                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +|  48        |

                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Angiectasis                          |                                     2                                    |      1  2.0|
      Basophilic Focus                     | X                                                                        |      1     |
      Basophilic Focus, Multiple           |                X                                                         |      1     |
      Clear Cell Focus                     |       X  X     X              X              X                           |      6     |
      Hematopoietic Cell Proliferation     |                                                                          |      1  1.0|
      Hepatodiaphragmatic Nodule           |                                                       X                  |      3     |
      Necrosis                             |                         3        3                                       |      2  3.0|
      Vacuolization Cytoplasmic            |       4     3                                                            |      5  3.4|

                                            __________________________________________________________________________|____________|
   Mesentery                               |       +     +           +              +  +        +                     |  10        |
      Fat, Necrosis                        |       3     3           3              3  2        3                     |      9  2.7|

                                            __________________________________________________________________________|____________|
   Oral Mucosa                             |                               +                                          |   1        |

                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Acinus, Atrophy                      |                            2                                             |      3  2.3|

                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Atrophy                              |                               4                                          |      1  4.0|

                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +|  49        |
      Inflammation, Suppurative            |             2                                                            |      3  2.3|
      Ulcer                                |    4                                                                     |      3  4.0|
      Epithelium, Hyperplasia              |    3        2                                                            |      3  2.7|

                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +|  49        |

                                            __________________________________________________________________________|____________|
   Tongue                                  |                                                                          |   1        |

                                            __________________________________________________________________________|____________|
   Tooth                                   |                                                                          |   1        |
      Degeneration                         |                                                                          |      1  4.0|

 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Blood Vessel                            | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inflammation                         |                                                                          |      1  4.0|

                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |

 __________________________________________________________________________________________________________________________________ 

  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
NTP Experiment-Test: 05184-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           GLUTARALDEHYDE                                      Date: 09/14/98  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 08:29:41  
                                                                                                                                    

 __________________________________________________________________________________________________________________________________ 
                                           | 6| 6| 6| 7| 6| 7| 7| 7| 7| 7| 6| 5| 5| 7| 7| 7| 7| 7| 6| 7| 6| 6| 7| 5| 7|            |
                             DAY ON TEST   | 6| 8| 8| 3| 5| 3| 3| 3| 2| 3| 6| 5| 8| 3| 3| 3| 3| 1| 7| 3| 8| 3| 3| 4| 3|            |
                                           | 0| 2| 0| 1| 1| 1| 1| 1| 2| 1| 6| 0| 9| 0| 0| 0| 1| 2| 4| 1| 0| 8| 1| 2| 0|      T (*) |

 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|      A     |
    CONTROL                                | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |

 __________________________________________________________________________________________________________________________________ 
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |            |
                                           |                                                                          |            |
      Atrium, Thrombosis                   |             4                                                            |      1  4.0|
      Myocardium, Fibrosis                 |          1                                1                       2      |      3  1.3|

 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Fibrosis                             |                                        3                                 |      1  3.0|
      Hematopoietic Cell Proliferation     |                                                                          |      1  2.0|
      Vacuolization Cytoplasmic            |          1           2                    3              3               |      7  2.3|

                                            __________________________________________________________________________|____________|
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia                          |                         1                                      1         |      2  1.0|

                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +|  49        |
      Hyperplasia                          |                                                                         2|      1  2.0|

                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  M  M  +  M  +  +  M  +  +  M  M  M  +  +  +|  42        |

                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cyst                                 |       2                          3                                       |      3  3.0|
      Hemorrhage                           |                                                                          |      1  4.0|
      Pars Distalis, Hyperplasia           |                                                             3            |      3  2.7|

                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      C-Cell, Hyperplasia                  |    4                                                                 3   |      3  2.7|

 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Tissue NOS                              |                                                          +               |   1        |

 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Clitoral Gland                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +|  49        |
      Cyst                                 |                                  3                                       |      1  3.0|
      Hyperplasia                          |             3     3  4           4                                       |      4  3.5|
      Inflammation, Suppurative            |                                                                          |      1  4.0|

                                            __________________________________________________________________________|____________|
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cyst                                 |             2                    4                                       |      2  3.0|
      Bilateral, Cyst                      |       4                                                                  |      1  4.0|

                                            __________________________________________________________________________|____________|
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hemorrhage                           |                                                                          |      1  4.0|

                                            __________________________________________________________________________|____________|
   Vagina                                  |                                                             +            |   1        |
      Inflammation                         |                                                             1            |      1  1.0|

 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |

                                            __________________________________________________________________________|____________|
   Lymph Node                              | +                                +                                       |   2        |

 __________________________________________________________________________________________________________________________________ 

  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
NTP Experiment-Test: 05184-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           GLUTARALDEHYDE                                      Date: 09/14/98  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 08:29:41  
                                                                                                                                    

 __________________________________________________________________________________________________________________________________ 
                                           | 6| 6| 6| 7| 6| 7| 7| 7| 7| 7| 6| 5| 5| 7| 7| 7| 7| 7| 6| 7| 6| 6| 7| 5| 7|            |
                             DAY ON TEST   | 6| 8| 8| 3| 5| 3| 3| 3| 2| 3| 6| 5| 8| 3| 3| 3| 3| 1| 7| 3| 8| 3| 3| 4| 3|            |
                                           | 0| 2| 0| 1| 1| 1| 1| 1| 2| 1| 6| 0| 9| 0| 0| 0| 1| 2| 4| 1| 0| 8| 1| 2| 0|      T (*) |

 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|      A     |
    CONTROL                                | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |

 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Lymph Node, Bronchial                   | +  +  +  M  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +|  46        |

                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +|  48        |

                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Infiltration Cellular, Histiocyte    |                                                                          |      1  3.0|

                                            __________________________________________________________________________|____________|
   Lymph Node, Mediastinal                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |

                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Fibrosis                             |                                                 2  2                     |      5  2.6|
      Hematopoietic Cell Proliferation     |                                                                          |      2  4.0|
      Hemorrhage                           | 3                                                                        |      1  3.0|

                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |

 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Galactocele                          |                                        3                                 |      2  3.5|
      Metaplasia, Squamous                 |                                                                          |      1  4.0|

                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cyst Epithelial Inclusion            |    X                                                                     |      1     |
      Hyperkeratosis                       |                                                       3                  |      2  3.0|
      Subcutaneous Tissue, Inflammation    |                               2                                          |      1  2.0|

 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |

                                            __________________________________________________________________________|____________|
   Skeletal Muscle                         |                               +                                          |   1        |

 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +|  49        |
      Hemorrhage                           |                                           4                              |      3  2.7|
      Hydrocephalus                        |    3                    3                 3                          4  3|     10  2.7|

                                            __________________________________________________________________________|____________|
   Spinal Cord                             |                                                                          |   1        |
      Neuron, Degeneration                 |                                                                          |      1  2.0|

 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Larynx                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +|  49        |
      Foreign Body                         |                            X  X                                          |      4     |
      Epiglottis, Inflammation, Suppurative|                                                                          |      1  4.0|
      Glands, Inflammation                 | 2  1                 1  1  1  2           1  1           2        1      |     20  1.5|
      Squamous Epithelium, Hyperplasia     | 2        2                                               1               |      5  2.2|

                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hemorrhage                           | 4                                                                        |      1  4.0|

 __________________________________________________________________________________________________________________________________ 

  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
NTP Experiment-Test: 05184-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           GLUTARALDEHYDE                                      Date: 09/14/98  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 08:29:41  
                                                                                                                                    

 __________________________________________________________________________________________________________________________________ 
                                           | 6| 6| 6| 7| 6| 7| 7| 7| 7| 7| 6| 5| 5| 7| 7| 7| 7| 7| 6| 7| 6| 6| 7| 5| 7|            |
                             DAY ON TEST   | 6| 8| 8| 3| 5| 3| 3| 3| 2| 3| 6| 5| 8| 3| 3| 3| 3| 1| 7| 3| 8| 3| 3| 4| 3|            |
                                           | 0| 2| 0| 1| 1| 1| 1| 1| 2| 1| 6| 0| 9| 0| 0| 0| 1| 2| 4| 1| 0| 8| 1| 2| 0|      T (*) |

 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|      A     |
    CONTROL                                | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |

 __________________________________________________________________________________________________________________________________ 
 RESPIRATORY SYSTEM - cont                 |                                                                          |            |
                                           |                                                                          |            |
      Inflammation, Chronic                |                                                                          |      1  4.0|
      Necrosis                             | 4                                                                        |      1  4.0|
      Alveolar Epithelium, Hyperplasia     |                   1  3                          1                        |      7  1.4|
      Alveolus, Hemorrhage                 |                   2                                                      |      1  2.0|
      Alveolus, Infiltration Cellular,     |                                                                          |            |
           Histiocyte                      |       1  2  1     2        1  1     1  2        1  1     1  1  1  2  1   |     29  1.5|
      Alveolus, Inflammation, Suppurative  |                                                                          |      2  1.5|
      Interstitium, Fibrosis               |          1                             1                          2      |      9  1.6|

                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Concretion                           |                                     2                                    |      2  2.0|
      Foreign Body                         |    X        X                                X  X                        |      5     |
      Goblet Cell, Respiratory Epithelium, |                                                                          |            |
           Hyperplasia                     |    2                                                                     |      1  2.0|
      Nasolacrimal Duct, Inflammation      |                                                                      4  4|      4  3.3|
      Olfactory Epithelium, Degeneration,  |                                                                          |            |
           Hyaline                         |                                        1  1                              |      4  1.0|
      Respiratory Epithelium, Hyperplasia  |                                              3                           |      1  3.0|
      Respiratory Epithelium, Inflammation |             2                    2           3  2                        |      5  2.2|
      Respiratory Epithelium, Metaplasia,  |                                                                          |            |
           Squamous                        |                                  2                                       |      1  2.0|
      Squamous Epithelium, Hyperplasia     |                                  2                                       |      3  1.3|
      Squamous Epithelium, Inflammation    |    3                    1        2                                      4|      6  2.5|

                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +|  49        |

 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Eye                                     |                                                                          |   2        |
      Cataract                             |                                                                          |      1  3.0|
      Degeneration                         |                                                                          |      1  4.0|

 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +|  49        |
      Mineralization                       |                                                                          |      1  1.0|
      Nephropathy, Chronic                 |    3  2  2  2  1     2  1  3  2     1  2  4  3  3  1     2     2  3  3  4|     38  2.1|
      Pelvis, Dilatation                   | 4                                                                        |      1  4.0|

                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +|  49        |

 __________________________________________________________________________________________________________________________________ 

  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
NTP Experiment-Test: 05184-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           GLUTARALDEHYDE                                      Date: 09/14/98  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 08:29:41  
                                                                                                                                    

 _____________________________________________________________________________________________________________________              
                                           | 5| 7| 7| 7| 7| 7| 6| 7| 7| 5| 5| 7| 6| 5| 1| 5| 4| 7| 7| 7| 6| 6| 7| 7| 7|             
                             DAY ON TEST   | 6| 3| 3| 3| 3| 3| 1| 3| 3| 4| 8| 3| 9| 6| 7| 9| 3| 3| 3| 3| 6| 1| 3| 2| 2|             
                                           | 1| 0| 1| 1| 1| 0| 5| 0| 1| 2| 9| 1| 4| 1| 8| 3| 7| 1| 0| 0| 6| 7| 1| 4| 6|             

 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    250 PPB                                | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             

 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +|             
      Parasite Metazoan                    |                               2              2     2                     |             

                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Parasite Metazoan                    |                                     1        1                           |             

                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +|             
      Parasite Metazoan                    |                                  1                 1                     |             

                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +|             

                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +|             

                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +|             

                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Basophilic Focus                     |    X                                                                     |             
      Clear Cell Focus                     |                               X  X                 X  X                  |             
      Clear Cell Focus, Multiple           |                   X     X                                                |             
      Hepatodiaphragmatic Nodule           |    X        X  X                                   X              X      |             
      Inflammation, Granulomatous          |                   2                                                      |             
      Vacuolization Cytoplasmic            |                                                                          |             

                                            __________________________________________________________________________|             
   Mesentery                               |          +  +           +                       +                 +  +   |             
      Fat, Necrosis                        |          3  1           3                       2                 3  2   |             

                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Acinus, Atrophy                      |                2                                                         |             

                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Suppurative            |                   3        4                                3            |             
      Ulcer                                |                                                                          |             
      Epithelium, Hyperplasia              |                                                                          |             

                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +|             
      Erosion                              |                                                                          |             
      Inflammation, Suppurative            |                                                                          |             

                                            __________________________________________________________________________|             
   Tongue                                  |                                                                          |             
      Hyperkeratosis                       |                                                                          |             
      Hyperplasia                          |                                                                          |             

                                            __________________________________________________________________________|             
   Tooth                                   |                                           +                              |             
      Degeneration                         |                                           4                              |             
      Inflammation, Suppurative            |                                           3                              |             

 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Blood Vessel                            | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation                         | 4                                                                        |             
      Thrombosis                           | 4                                                                        |             

                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrium, Thrombosis                   |                                                                      2   |             
      Myocardium, Fibrosis                 |                         1                                                |             

 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             

 _____________________________________________________________________________________________________________________|             
NTP Experiment-Test: 05184-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           GLUTARALDEHYDE                                      Date: 09/14/98  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 08:29:41  
                                                                                                                                    

 _____________________________________________________________________________________________________________________              
                                           | 5| 7| 7| 7| 7| 7| 6| 7| 7| 5| 5| 7| 6| 5| 1| 5| 4| 7| 7| 7| 6| 6| 7| 7| 7|             
                             DAY ON TEST   | 6| 3| 3| 3| 3| 3| 1| 3| 3| 4| 8| 3| 9| 6| 7| 9| 3| 3| 3| 3| 6| 1| 3| 2| 2|             
                                           | 1| 0| 1| 1| 1| 0| 5| 0| 1| 2| 9| 1| 4| 1| 8| 3| 7| 1| 0| 0| 6| 7| 1| 4| 6|             

 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    250 PPB                                | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             

 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                                                                          |             
      Vacuolization Cytoplasmic            |             2        1                             3                     |             

                                            __________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                                                      2   |             

                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  M  +  +  +  +  +  +  +  +  +  +  +  M  M  M  +  +  M  +  +  +  M  +  +|             

                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                                                          |             
      Pars Distalis, Hyperplasia           |                4                                                         |             

                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      C-Cell, Hyperplasia                  |                      4                             3                     |             

 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Tissue NOS                              |                               +                                          |             

 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Clitoral Gland                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                      3           4                       4               |             
      Inflammation, Suppurative            |                      3                                                   |             

                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                              3                           |             

                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cervix, Myometrium, Hypertrophy      |                                                                          |             

 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

                                            __________________________________________________________________________|             
   Lymph Node                              |                            +                                             |             

                                            __________________________________________________________________________|             
   Lymph Node, Bronchial                   | +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

                                            __________________________________________________________________________|             
   Lymph Node, Mediastinal                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrosis                             |                                                    3           4     3   |             
      Hematopoietic Cell Proliferation     |                                                    4                     |             

                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Galactocele                          |                                                                      4   |             

                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst Epithelial Inclusion            |       X           X                 X                                    |             

 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             

 _____________________________________________________________________________________________________________________|             
NTP Experiment-Test: 05184-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           GLUTARALDEHYDE                                      Date: 09/14/98  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 08:29:41  
                                                                                                                                    

 _____________________________________________________________________________________________________________________              
                                           | 5| 7| 7| 7| 7| 7| 6| 7| 7| 5| 5| 7| 6| 5| 1| 5| 4| 7| 7| 7| 6| 6| 7| 7| 7|             
                             DAY ON TEST   | 6| 3| 3| 3| 3| 3| 1| 3| 3| 4| 8| 3| 9| 6| 7| 9| 3| 3| 3| 3| 6| 1| 3| 2| 2|             
                                           | 1| 0| 1| 1| 1| 0| 5| 0| 1| 2| 9| 1| 4| 1| 8| 3| 7| 1| 0| 0| 6| 7| 1| 4| 6|             

 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    250 PPB                                | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             

 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM - cont             |                                                                          |             
                                           |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |                   2                                                      |             
      Hydrocephalus                        |             1     4  2        2  1  2  2                                 |             

                                            __________________________________________________________________________|             
   Spinal Cord                             |                                     +                                    |             
      Demyelination                        |                                     3                                    |             

 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Larynx                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Foreign Body                         |                               X                    X           X         |             
      Glands, Inflammation                 |                   1        1  2  1  1              2                     |             
      Squamous Epithelium, Hyperplasia     |                                                                          |             

                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Alveolar Epithelium, Hyperplasia     |                                                       3                  |             
      Alveolus, Infiltration Cellular,     |                                                                          |             
           Histiocyte                      | 2  1  1  1  1        1           1  1     3  1        1  1  1  1        1|             
      Alveolus, Inflammation, Suppurative  |                                                       1                  |             
      Interstitium, Fibrosis               |       1     1                    1  1        1           1  1           1|             
      Venule, Thrombosis                   |                                        2                                 |             

                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Foreign Body                         |                                  X                                       |             
      Goblet Cell, Respiratory Epithelium, |                                                                          |             
           Hyperplasia                     |                      2                                                   |             
      Nasolacrimal Duct, Inflammation      |                                                    2                     |             
      Olfactory Epithelium, Degeneration,  |                                                                          |             
           Hyaline                         |          1                                                        1      |             
      Respiratory Epithelium, Hyperplasia  |                                                                          |             
      Respiratory Epithelium, Inflammation |                1                 2                                1      |             
      Respiratory Epithelium, Metaplasia,  |                                                                          |             
           Squamous                        |                                                                          |             
      Squamous Epithelium, Hyperplasia     | 2                 1                                2                 2  1|             
      Squamous Epithelium, Inflammation    | 2  1  1           1        1  1        1     1     2  1           1  3  1|             

                                            __________________________________________________________________________|             
   Pleura                                  |                                                                          |             
      Hyperplasia, Focal                   |                                                                          |             
      Inflammation, Chronic                |                                                                          |             

                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Eye                                     |                      +                                                   |             
      Atrophy                              |                      4                                                   |             
      Cataract                             |                                                                          |             

 _____________________________________________________________________________________________________________________|             
NTP Experiment-Test: 05184-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           GLUTARALDEHYDE                                      Date: 09/14/98  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 08:29:41  
                                                                                                                                    

 _____________________________________________________________________________________________________________________              
                                           | 5| 7| 7| 7| 7| 7| 6| 7| 7| 5| 5| 7| 6| 5| 1| 5| 4| 7| 7| 7| 6| 6| 7| 7| 7|             
                             DAY ON TEST   | 6| 3| 3| 3| 3| 3| 1| 3| 3| 4| 8| 3| 9| 6| 7| 9| 3| 3| 3| 3| 6| 1| 3| 2| 2|             
                                           | 1| 0| 1| 1| 1| 0| 5| 0| 1| 2| 9| 1| 4| 1| 8| 3| 7| 1| 0| 0| 6| 7| 1| 4| 6|             

 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    250 PPB                                | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             

 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM - cont              |                                                                          |             
                                           |                                                                          |             

 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Nephropathy, Chronic                 | 2  2  3  3  2  2  3  3  1     2  2  1  2     2  1  3  2  1  1  1     2   |             

                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

 _____________________________________________________________________________________________________________________|             
NTP Experiment-Test: 05184-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           GLUTARALDEHYDE                                      Date: 09/14/98  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 08:29:41  
                                                                                                                                    

 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 1| 7| 6| 7| 7| 7| 7| 7| 6| 6| 7|            |
                             DAY ON TEST   | 3| 3| 2| 1| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 1| 3| 0| 3| 3| 3| 3| 3| 7| 7| 3|            |
                                           | 0| 0| 0| 2| 1| 1| 0| 1| 0| 1| 0| 1| 1| 1| 7| 0| 6| 1| 1| 0| 1| 1| 4| 5| 0|      T (*) |

 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|      A     |
    250 PPB                                | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |

 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |

                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Parasite Metazoan                    |                                              2                           |      4  2.0|

                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Parasite Metazoan                    |                                                          1     1         |      4  1.0|

                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +|  48        |
      Parasite Metazoan                    |                            1        1                                    |      4  1.0|

                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |

                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +|  48        |

                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +|  48        |

                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Basophilic Focus                     |                                              X                           |      2     |
      Clear Cell Focus                     |                                                                          |      4     |
      Clear Cell Focus, Multiple           |                                     X                                    |      3     |
      Hepatodiaphragmatic Nodule           |    X                                                                     |      6     |
      Inflammation, Granulomatous          |                                                                          |      1  2.0|
      Vacuolization Cytoplasmic            |                4                                                         |      1  4.0|

                                            __________________________________________________________________________|____________|
   Mesentery                               |          +                                   +              +            |   9        |
      Fat, Necrosis                        |          2                                   2              3            |      9  2.3|

                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Acinus, Atrophy                      |                   2           1                                          |      3  1.7|

                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |

                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inflammation, Suppurative            |          3                                                               |      4  3.3|
      Ulcer                                |       4        4                                                         |      2  4.0|
      Epithelium, Hyperplasia              | 4        2     3                                                     3   |      4  3.0|

                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Erosion                              |       2                                                                  |      1  2.0|
      Inflammation, Suppurative            |          2                                                               |      1  2.0|

                                            __________________________________________________________________________|____________|
   Tongue                                  |                                                                         +|   1        |
      Hyperkeratosis                       |                                                                         3|      1  3.0|
      Hyperplasia                          |                                                                         3|      1  3.0|

                                            __________________________________________________________________________|____________|
   Tooth                                   |                                           +                              |   2        |
      Degeneration                         |                                           1                              |      2  2.5|
      Inflammation, Suppurative            |                                                                          |      1  3.0|

 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Blood Vessel                            | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inflammation                         |                                                                          |      1  4.0|

 __________________________________________________________________________________________________________________________________ 

  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
NTP Experiment-Test: 05184-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           GLUTARALDEHYDE                                      Date: 09/14/98  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 08:29:41  
                                                                                                                                    

 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 1| 7| 6| 7| 7| 7| 7| 7| 6| 6| 7|            |
                             DAY ON TEST   | 3| 3| 2| 1| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 1| 3| 0| 3| 3| 3| 3| 3| 7| 7| 3|            |
                                           | 0| 0| 0| 2| 1| 1| 0| 1| 0| 1| 0| 1| 1| 1| 7| 0| 6| 1| 1| 0| 1| 1| 4| 5| 0|      T (*) |

 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|      A     |
    250 PPB                                | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |

 __________________________________________________________________________________________________________________________________ 
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |            |
                                           |                                                                          |            |
      Thrombosis                           |                                                                          |      1  4.0|

                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Atrium, Thrombosis                   |                                                                          |      1  2.0|
      Myocardium, Fibrosis                 |                                                                          |      1  1.0|

 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Atrophy                              |                                                          4               |      1  4.0|
      Vacuolization Cytoplasmic            |             2              2                                         3   |      6  2.2|

                                            __________________________________________________________________________|____________|
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia                          |                                                                          |      1  2.0|

                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |

                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  M  +  +  +  +  +  +  M  +  +  +  M  +  M  +  +  +  +  +  +  M  +  +|  39        |

                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cyst                                 |                                                          3               |      1  3.0|
      Pars Distalis, Hyperplasia           |       4                             3              4                     |      4  3.8|

                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      C-Cell, Hyperplasia                  |                            3                                            4|      4  3.5|

 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Tissue NOS                              |                                                                          |   1        |

 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Clitoral Gland                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia                          |                                  3                    4           3  4   |      7  3.6|
      Inflammation, Suppurative            |                                                                          |      1  3.0|

                                            __________________________________________________________________________|____________|
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cyst                                 |                                        3                          3      |      3  3.0|

                                            __________________________________________________________________________|____________|
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cervix, Myometrium, Hypertrophy      |                4                                                         |      1  4.0|

 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |

                                            __________________________________________________________________________|____________|
   Lymph Node                              |                                              +                       +   |   3        |

                                            __________________________________________________________________________|____________|
   Lymph Node, Bronchial                   | +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  M  +  +  +  M  +  +  +|  46        |

                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |

                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |

                                            __________________________________________________________________________|____________|
   Lymph Node, Mediastinal                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |

                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |

 __________________________________________________________________________________________________________________________________ 

  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
NTP Experiment-Test: 05184-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           GLUTARALDEHYDE                                      Date: 09/14/98  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 08:29:41  
                                                                                                                                    

 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 1| 7| 6| 7| 7| 7| 7| 7| 6| 6| 7|            |
                             DAY ON TEST   | 3| 3| 2| 1| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 1| 3| 0| 3| 3| 3| 3| 3| 7| 7| 3|            |
                                           | 0| 0| 0| 2| 1| 1| 0| 1| 0| 1| 0| 1| 1| 1| 7| 0| 6| 1| 1| 0| 1| 1| 4| 5| 0|      T (*) |

 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|      A     |
    250 PPB                                | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |

 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
      Fibrosis                             | 2     3                       2              3                           |      7  2.9|
      Hematopoietic Cell Proliferation     |                                                                          |      1  4.0|

                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |

 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Galactocele                          |                                                             2            |      2  3.0|

                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cyst Epithelial Inclusion            |                                                                          |      3     |

 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |

 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hemorrhage                           |                                                                          |      1  2.0|
      Hydrocephalus                        |                2     2           2                                       |     10  2.0|

                                            __________________________________________________________________________|____________|
   Spinal Cord                             |                                           +                              |   2        |
      Demyelination                        |                                           1                              |      2  2.0|

 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Larynx                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Foreign Body                         |                                                                          |      3     |
      Glands, Inflammation                 |       2     1           1  1  1     1                 1     1  1  2      |     16  1.3|
      Squamous Epithelium, Hyperplasia     |                                                       2                  |      1  2.0|

                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Alveolar Epithelium, Hyperplasia     |                               1     1                          3         |      4  2.0|
      Alveolus, Infiltration Cellular,     |                                                                          |            |
           Histiocyte                      |             2     1  1  1     2  1     1     1                          1|     24  1.2|
      Alveolus, Inflammation, Suppurative  |                                                                          |      1  1.0|
      Interstitium, Fibrosis               |             2        1  1     2     2                                    |     13  1.2|
      Venule, Thrombosis                   |                                                                          |      1  2.0|

                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Foreign Body                         |                            X                          X                  |      3     |
      Goblet Cell, Respiratory Epithelium, |                                                                          |            |
           Hyperplasia                     | 1                                                                 1      |      3  1.3|
      Nasolacrimal Duct, Inflammation      |          3                                                               |      2  2.5|
      Olfactory Epithelium, Degeneration,  |                                                                          |            |
           Hyaline                         |                   1                                            1     1   |      5  1.0|

 __________________________________________________________________________________________________________________________________ 

  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
NTP Experiment-Test: 05184-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           GLUTARALDEHYDE                                      Date: 09/14/98  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 08:29:41  
                                                                                                                                    

 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 1| 7| 6| 7| 7| 7| 7| 7| 6| 6| 7|            |
                             DAY ON TEST   | 3| 3| 2| 1| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 1| 3| 0| 3| 3| 3| 3| 3| 7| 7| 3|            |
                                           | 0| 0| 0| 2| 1| 1| 0| 1| 0| 1| 0| 1| 1| 1| 7| 0| 6| 1| 1| 0| 1| 1| 4| 5| 0|      T (*) |

 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|      A     |
    250 PPB                                | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |

 __________________________________________________________________________________________________________________________________ 
 RESPIRATORY SYSTEM - cont                 |                                                                          |            |
                                           |                                                                          |            |
      Respiratory Epithelium, Hyperplasia  | 2              2           1                          2  2           1   |      6  1.7|
      Respiratory Epithelium, Inflammation |                1           4  1                       2  1           2   |      9  1.7|
      Respiratory Epithelium, Metaplasia,  |                                                                          |            |
           Squamous                        |                            3                                             |      1  3.0|
      Squamous Epithelium, Hyperplasia     |          1     2     1     3  1                 1     1  2        2  3   |     15  1.7|
      Squamous Epithelium, Inflammation    | 2        3     1     1     4  2  1           1  1     2  1        1  2   |     26  1.5|

                                            __________________________________________________________________________|____________|
   Pleura                                  |             +                       +                                    |   2        |
      Hyperplasia, Focal                   |             2                                                            |      1  2.0|
      Inflammation, Chronic                |                                     2                                    |      1  2.0|

                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |

 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Eye                                     |       +                                                                  |   2        |
      Atrophy                              |                                                                          |      1  4.0|
      Cataract                             |       2                                                                  |      1  2.0|

 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Nephropathy, Chronic                 | 4  1  2     2  2  3  3  1  3  3  3  2  1     2     2  1  2  1  2  1     1|     42  2.0|

                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |

 __________________________________________________________________________________________________________________________________ 

  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
NTP Experiment-Test: 05184-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           GLUTARALDEHYDE                                      Date: 09/14/98  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 08:29:41  
                                                                                                                                    

 _____________________________________________________________________________________________________________________              
                                           | 6| 6| 4| 5| 6| 7| 7| 5| 5| 3| 3| 7| 6| 6| 5| 7| 6| 7| 6| 7| 7| 7| 6| 6| 5|             
                             DAY ON TEST   | 7| 1| 5| 1| 3| 2| 3| 8| 4| 5| 5| 3| 6| 7| 8| 3| 7| 0| 8| 1| 3| 3| 1| 1| 0|             
                                           | 4| 4| 5| 3| 8| 4| 0| 3| 4| 5| 7| 0| 0| 6| 9| 0| 6| 3| 0| 6| 0| 0| 9| 7| 8|             

 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
    500 PPB                                | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             

 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Parasite Metazoan                    |                                                                          |             

                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Parasite Metazoan                    | 1                             1                                          |             

                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Parasite Metazoan                    |                                                          1               |             

                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                2                                                     2   |             
      Basophilic Focus                     |                                                                          |             
      Basophilic Focus, Multiple           |                                                       X              X   |             
      Clear Cell Focus                     |                X                                X                       X|             
      Clear Cell Focus, Multiple           |                         X                 X                              |             
      Hematopoietic Cell Proliferation     |                                                                          |             
      Hepatodiaphragmatic Nodule           |                X                                                        X|             

                                            __________________________________________________________________________|             
   Mesentery                               |                                        +     +                           |             
      Inflammation, Granulomatous          |                                                                          |             
      Fat, Necrosis                        |                                        3     3                           |             

                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Acinus, Atrophy                      |                1                                                  4      |             

                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperkeratosis                       |                                        3                                 |             
      Inflammation, Suppurative            |                                                                          |             
      Ulcer                                |                                                    4                     |             
      Epithelium, Hyperplasia              |                                        3                                 |             

                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Erosion                              |                            4                                             |             
      Inflammation, Suppurative            |                            2                                             |             

 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Blood Vessel                            | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Mineralization                       |                                                       4                  |             

                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Myocardium, Fibrosis                 |                                                 2           2            |             

 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hematopoietic Cell Proliferation     |                                                                          |             
      Hemorrhage                           |                                        2                                 |             
      Vacuolization Cytoplasmic            |    2              1                    1                          2      |             

 _____________________________________________________________________________________________________________________|             
NTP Experiment-Test: 05184-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           GLUTARALDEHYDE                                      Date: 09/14/98  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 08:29:41  
                                                                                                                                    

 _____________________________________________________________________________________________________________________              
                                           | 6| 6| 4| 5| 6| 7| 7| 5| 5| 3| 3| 7| 6| 6| 5| 7| 6| 7| 6| 7| 7| 7| 6| 6| 5|             
                             DAY ON TEST   | 7| 1| 5| 1| 3| 2| 3| 8| 4| 5| 5| 3| 6| 7| 8| 3| 7| 0| 8| 1| 3| 3| 1| 1| 0|             
                                           | 4| 4| 5| 3| 8| 4| 0| 3| 4| 5| 7| 0| 0| 6| 9| 0| 6| 3| 0| 6| 0| 0| 9| 7| 8|             

 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
    500 PPB                                | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             

 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                                                          |             

                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                                                          |             

                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                                 2                        |             
      Hemorrhage                           |          4                                                               |             
      Pars Distalis, Hyperplasia           |                                        3                                 |             

                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      C-Cell, Hyperplasia                  | 3                                                  3           3         |             

 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Tissue NOS                              |                                                                          |             

 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Clitoral Gland                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                               2                 4              2         |             

                                            __________________________________________________________________________|             
   Oviduct                                 |                                     +                                    |             
      Cyst                                 |                                     3                                    |             

                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |       4                                                                  |             
      Hydrometra                           |                                     3                                    |             

 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrosis                             |                                                                3         |             

                                            __________________________________________________________________________|             
   Lymph Node                              |                                                          +               |             

                                            __________________________________________________________________________|             
   Lymph Node, Bronchial                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrosis                             |                                                    2                     |             

                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +|             

                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

                                            __________________________________________________________________________|             
   Lymph Node, Mediastinal                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Accessory Spleen                     |                            X                                             |             
      Fibrosis                             |          3                                                     2     1   |             
      Hematopoietic Cell Proliferation     |                                                                          |             
      Hemorrhage                           |                            4                                             |             

                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                                                2         |             

 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

 _____________________________________________________________________________________________________________________|             
NTP Experiment-Test: 05184-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           GLUTARALDEHYDE                                      Date: 09/14/98  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 08:29:41  
                                                                                                                                    

 _____________________________________________________________________________________________________________________              
                                           | 6| 6| 4| 5| 6| 7| 7| 5| 5| 3| 3| 7| 6| 6| 5| 7| 6| 7| 6| 7| 7| 7| 6| 6| 5|             
                             DAY ON TEST   | 7| 1| 5| 1| 3| 2| 3| 8| 4| 5| 5| 3| 6| 7| 8| 3| 7| 0| 8| 1| 3| 3| 1| 1| 0|             
                                           | 4| 4| 5| 3| 8| 4| 0| 3| 4| 5| 7| 0| 0| 6| 9| 0| 6| 3| 0| 6| 0| 0| 9| 7| 8|             

 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
    500 PPB                                | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             

 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Epithelium, Hyperplasia              |                                           4                              |             

                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Ulcer                                |                            2                                             |             
      Hair Follicle, Inflammation, Chronic |                                                          2               |             

 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Osteopetrosis                        |                                                                          |             

                                            __________________________________________________________________________|             
   Skeletal Muscle                         |                                                                          |             

 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |          2                 4  3                    1                    2|             
      Hydrocephalus                        | 2                       2                 3              2              2|             

 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Larynx                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Foreign Body                         |    X                                                           X         |             
      Epiglottis, Inflammation, Suppurative|                                                                          |             
      Glands, Inflammation                 | 1     1     1        1  1              2                 1     2         |             
      Squamous Epithelium, Hyperplasia     |                                                                          |             

                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Alveolar Epithelium, Hyperplasia     |                                                             2        1   |             
      Alveolus, Hemorrhage                 |                                                                          |             
      Alveolus, Infiltration Cellular,     |                                                                          |             
           Histiocyte                      | 2  1              1  2     1     1     3     3        1  1  2        2  1|             
      Interstitium, Fibrosis               | 2  1              1  2     1     1     2     2        1  1        1      |             

                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Foreign Body                         |                                                                          |             
      Goblet Cell, Respiratory Epithelium, |                                                                          |             
           Hyperplasia                     |                                           1     1        1               |             
      Nasolacrimal Duct, Inflammation      |                                        4                                 |             
      Olfactory Epithelium, Degeneration,  |                                                                          |             
           Hyaline                         | 1                       1              2  1     1     1        1         |             
      Olfactory Epithelium, Inflammation   |                                                                          |             
      Respiratory Epithelium, Hyperplasia  | 2           2              2     2  2           2  3  2  2        2      |             
      Respiratory Epithelium, Inflammation | 3  2        2           1  4     2  3  2  1  1  3  4  3  2  1        2  1|             
      Respiratory Epithelium, Metaplasia,  |                                                                          |             
           Squamous                        | 2           1                    2  2              2     1        2  2   |             
      Septum, Respiratory Epithelium, Ulcer|                            4                                             |             
      Squamous Epithelium, Hyperplasia     | 3  2     2  3     2  1     2     1  3  2     1  3  3  3  3     2  2  3   |             
      Squamous Epithelium, Inflammation    | 4  3  2  2  3  1  2  1     4  1     4  3  1  1  4  4  4  3  1  2  2  3  1|             

                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             

 _____________________________________________________________________________________________________________________|             
NTP Experiment-Test: 05184-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           GLUTARALDEHYDE                                      Date: 09/14/98  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 08:29:41  
                                                                                                                                    

 _____________________________________________________________________________________________________________________              
                                           | 6| 6| 4| 5| 6| 7| 7| 5| 5| 3| 3| 7| 6| 6| 5| 7| 6| 7| 6| 7| 7| 7| 6| 6| 5|             
                             DAY ON TEST   | 7| 1| 5| 1| 3| 2| 3| 8| 4| 5| 5| 3| 6| 7| 8| 3| 7| 0| 8| 1| 3| 3| 1| 1| 0|             
                                           | 4| 4| 5| 3| 8| 4| 0| 3| 4| 5| 7| 0| 0| 6| 9| 0| 6| 3| 0| 6| 0| 0| 9| 7| 8|             

 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
    500 PPB                                | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             

 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM - cont              |                                                                          |             
                                           |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Eye                                     |                               +                                          |             
      Cataract                             |                               2                                          |             

                                            __________________________________________________________________________|             
   Zymbal's Gland                          |                                                                          |             

 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Nephropathy, Chronic                 | 2  2              1     3     2  1  2  1  3  2  2  2     1  2  2        2|             

                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

 _____________________________________________________________________________________________________________________|             
NTP Experiment-Test: 05184-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           GLUTARALDEHYDE                                      Date: 09/14/98  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 08:29:41  
                                                                                                                                    

 __________________________________________________________________________________________________________________________________ 
                                           | 6| 7| 7| 7| 7| 4| 5| 7| 6| 7| 5| 6| 7| 6| 6| 7| 7| 5| 5| 7| 7| 7| 6| 2| 7|            |
                             DAY ON TEST   | 7| 0| 3| 1| 3| 6| 3| 3| 3| 3| 5| 5| 3| 1| 6| 3| 3| 4| 3| 3| 1| 3| 3| 7| 3|            |
                                           | 4| 9| 0| 1| 0| 9| 3| 0| 4| 1| 8| 4| 0| 7| 2| 1| 1| 3| 3| 0| 5| 0| 8| 6| 1|      T (*) |

 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|      A     |
    500 PPB                                | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |

 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |

                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Parasite Metazoan                    |                               2                                          |      1  2.0|

                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Parasite Metazoan                    |             1                       1                                    |      4  1.0|

                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Parasite Metazoan                    |    1                          1                                          |      3  1.0|

                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |

                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |

                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |

                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Angiectasis                          |                                                                          |      2  2.0|
      Basophilic Focus                     |                                                                         X|      1     |
      Basophilic Focus, Multiple           |                                                                          |      2     |
      Clear Cell Focus                     |                                                                         X|      4     |
      Clear Cell Focus, Multiple           |                                                                          |      2     |
      Hematopoietic Cell Proliferation     |                                                                      3   |      1  3.0|
      Hepatodiaphragmatic Nodule           |                                                                   X      |      3     |

                                            __________________________________________________________________________|____________|
   Mesentery                               |          +           +  +                 +                             +|   7        |
      Inflammation, Granulomatous          |                         3                                                |      1  3.0|
      Fat, Necrosis                        |          2           2  4                 3                             3|      7  2.9|

                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Acinus, Atrophy                      |                                  2                                       |      3  2.3|

                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |

                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperkeratosis                       |                                                                          |      1  3.0|
      Inflammation, Suppurative            |                                                    2        3            |      2  2.5|
      Ulcer                                |                                                             4            |      2  4.0|
      Epithelium, Hyperplasia              |                                                    1        3            |      3  2.3|

                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Erosion                              |                                                                          |      1  4.0|
      Inflammation, Suppurative            |                                                             2            |      2  2.0|

 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Blood Vessel                            | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Mineralization                       |                                                                          |      1  4.0|

                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Myocardium, Fibrosis                 |             2              1                                             |      4  1.8|

 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |

 __________________________________________________________________________________________________________________________________ 

  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
NTP Experiment-Test: 05184-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           GLUTARALDEHYDE                                      Date: 09/14/98  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 08:29:41  
                                                                                                                                    

 __________________________________________________________________________________________________________________________________ 
                                           | 6| 7| 7| 7| 7| 4| 5| 7| 6| 7| 5| 6| 7| 6| 6| 7| 7| 5| 5| 7| 7| 7| 6| 2| 7|            |
                             DAY ON TEST   | 7| 0| 3| 1| 3| 6| 3| 3| 3| 3| 5| 5| 3| 1| 6| 3| 3| 4| 3| 3| 1| 3| 3| 7| 3|            |
                                           | 4| 9| 0| 1| 0| 9| 3| 0| 4| 1| 8| 4| 0| 7| 2| 1| 1| 3| 3| 0| 5| 0| 8| 6| 1|      T (*) |

 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|      A     |
    500 PPB                                | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |

 __________________________________________________________________________________________________________________________________ 
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
                                           |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hematopoietic Cell Proliferation     |                                                                      2   |      1  2.0|
      Hemorrhage                           |                                                                          |      1  2.0|
      Vacuolization Cytoplasmic            |    3     2  1              1     1     2  1                              |     11  1.5|

                                            __________________________________________________________________________|____________|
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia                          |                   1  1                                                   |      2  1.0|

                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |

                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | M  +  +  +  +  +  +  +  +  +  M  M  +  +  +  +  M  +  +  +  +  +  +  +  +|  44        |
      Hyperplasia                          |             2                                      2                     |      2  2.0|

                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cyst                                 |                         3     1                                          |      3  2.0|
      Hemorrhage                           |                                                                          |      1  4.0|
      Pars Distalis, Hyperplasia           |             2        3                 3                                 |      4  2.8|

                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      C-Cell, Hyperplasia                  |                                                          2               |      4  2.8|

 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Tissue NOS                              |                                                                         +|   1        |

 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Clitoral Gland                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |

                                            __________________________________________________________________________|____________|
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cyst                                 |       2  3              3                                2               |      7  2.6|

                                            __________________________________________________________________________|____________|
   Oviduct                                 |                                                                          |   1        |
      Cyst                                 |                                                                          |      1  3.0|

                                            __________________________________________________________________________|____________|
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hemorrhage                           |                                                                          |      1  4.0|
      Hydrometra                           |                                                                          |      1  3.0|

 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Fibrosis                             |                               1                                          |      2  2.0|

                                            __________________________________________________________________________|____________|
   Lymph Node                              |          +                    +                                          |   3        |

                                            __________________________________________________________________________|____________|
   Lymph Node, Bronchial                   | +  +  +  M  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Fibrosis                             |                                                                          |      1  2.0|

                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +|  48        |

                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |

                                            __________________________________________________________________________|____________|
   Lymph Node, Mediastinal                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |

 __________________________________________________________________________________________________________________________________ 

  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
NTP Experiment-Test: 05184-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           GLUTARALDEHYDE                                      Date: 09/14/98  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 08:29:41  
                                                                                                                                    

 __________________________________________________________________________________________________________________________________ 
                                           | 6| 7| 7| 7| 7| 4| 5| 7| 6| 7| 5| 6| 7| 6| 6| 7| 7| 5| 5| 7| 7| 7| 6| 2| 7|            |
                             DAY ON TEST   | 7| 0| 3| 1| 3| 6| 3| 3| 3| 3| 5| 5| 3| 1| 6| 3| 3| 4| 3| 3| 1| 3| 3| 7| 3|            |
                                           | 4| 9| 0| 1| 0| 9| 3| 0| 4| 1| 8| 4| 0| 7| 2| 1| 1| 3| 3| 0| 5| 0| 8| 6| 1|      T (*) |

 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|      A     |
    500 PPB                                | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |

 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Accessory Spleen                     |                                                                          |      1     |
      Fibrosis                             |    2                                               3  1     3     3      |      8  2.3|
      Hematopoietic Cell Proliferation     |                                                                      4   |      1  4.0|
      Hemorrhage                           |                                                             4            |      2  4.0|

                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cyst                                 |                                                                          |      1  2.0|

 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Epithelium, Hyperplasia              |                                                                   3      |      2  3.5|

                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Ulcer                                |                                                                          |      1  2.0|
      Hair Follicle, Inflammation, Chronic |                                                                          |      1  2.0|

 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Osteopetrosis                        |             4                                                            |      1  4.0|

                                            __________________________________________________________________________|____________|
   Skeletal Muscle                         |                                                                      +   |   1        |

 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hemorrhage                           |                2  1                                                      |      7  2.1|
      Hydrocephalus                        | 1                                         2                              |      7  2.0|

 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Larynx                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Foreign Body                         |                                                                          |      2     |
      Epiglottis, Inflammation, Suppurative|             2                                      1                     |      2  1.5|
      Glands, Inflammation                 | 1  1        2     2     1  1  1                          1  2           1|     18  1.3|
      Squamous Epithelium, Hyperplasia     |                         1                                                |      1  1.0|

                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Alveolar Epithelium, Hyperplasia     |                                                                          |      2  1.5|
      Alveolus, Hemorrhage                 |                                                       1                  |      1  1.0|
      Alveolus, Infiltration Cellular,     |                                                                          |            |
           Histiocyte                      | 2  1     1           2  3  1  2           1                    1         |     22  1.6|
      Interstitium, Fibrosis               | 2                    1  1     1  1                             1         |     17  1.3|

                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Foreign Body                         |             X        X                                                   |      2     |

 __________________________________________________________________________________________________________________________________ 

  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
NTP Experiment-Test: 05184-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           GLUTARALDEHYDE                                      Date: 09/14/98  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 08:29:41  
                                                                                                                                    

 __________________________________________________________________________________________________________________________________ 
                                           | 6| 7| 7| 7| 7| 4| 5| 7| 6| 7| 5| 6| 7| 6| 6| 7| 7| 5| 5| 7| 7| 7| 6| 2| 7|            |
                             DAY ON TEST   | 7| 0| 3| 1| 3| 6| 3| 3| 3| 3| 5| 5| 3| 1| 6| 3| 3| 4| 3| 3| 1| 3| 3| 7| 3|            |
                                           | 4| 9| 0| 1| 0| 9| 3| 0| 4| 1| 8| 4| 0| 7| 2| 1| 1| 3| 3| 0| 5| 0| 8| 6| 1|      T (*) |

 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|      A     |
    500 PPB                                | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |

 __________________________________________________________________________________________________________________________________ 
 RESPIRATORY SYSTEM - cont                 |                                                                          |            |
                                           |                                                                          |            |
      Goblet Cell, Respiratory Epithelium, |                                                                          |            |
           Hyperplasia                     |             2  2                                                         |      5  1.4|
      Nasolacrimal Duct, Inflammation      |                                                                2         |      2  3.0|
      Olfactory Epithelium, Degeneration,  |                                                                          |            |
           Hyaline                         | 1                 1           1           1  1                           |     12  1.1|
      Olfactory Epithelium, Inflammation   |          3                                                               |      1  3.0|
      Respiratory Epithelium, Hyperplasia  |                   2     1     1  2           1                           |     15  1.9|
      Respiratory Epithelium, Inflammation | 1        3  3     2     2        4        1  1                          1|     26  2.1|
      Respiratory Epithelium, Metaplasia,  |                                                                          |            |
           Squamous                        |                   2     1        1                                       |     11  1.6|
      Septum, Respiratory Epithelium, Ulcer|                                                                          |      1  4.0|
      Squamous Epithelium, Hyperplasia     |    2  1  1              2        2           2     2  1     2  1     2   |     29  2.0|
      Squamous Epithelium, Inflammation    | 1  2  1  2  1  1  1     3  2  1  4     1     1     2  1     4  1  1  4   |     42  2.1|

                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |

 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Eye                                     |       +                          +                                       |   3        |
      Cataract                             |       2                          1                                       |      3  1.7|

                                            __________________________________________________________________________|____________|
   Zymbal's Gland                          |                      +                                                   |   1        |

 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Nephropathy, Chronic                 | 1  3  2  2  2  1  1  2  1  2     1  2  2  1  2     4     2  2  4  1     2|     37  1.9|

                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |

 __________________________________________________________________________________________________________________________________ 

  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
NTP Experiment-Test: 05184-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           GLUTARALDEHYDE                                      Date: 09/14/98  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 08:29:41  
                                                                                                                                    

 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 7| 7| 5| 4| 5| 4| 1| 7| 7| 7| 3| 7| 7| 1| 7| 7| 5| 7| 5| 7| 7| 5| 0|             
                             DAY ON TEST   | 3| 3| 1| 3| 1| 3| 6| 7| 1| 3| 3| 3| 7| 0| 1| 1| 0| 3| 6| 3| 1| 3| 3| 1| 3|             
                                           | 0| 0| 6| 0| 4| 2| 9| 4| 3| 1| 1| 0| 5| 8| 8| 7| 2| 0| 7| 0| 2| 0| 0| 6| 2|             

 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
    750 PPB                                | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             

 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Diverticulum                         | X                                                                        |             
      Parasite Metazoan                    | 2                                                                        |             

                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Parasite Metazoan                    |       1           1        1                                             |             

                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +|             

                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Basophilic Focus                     |                                                                          |             
      Basophilic Focus, Multiple           |          X                                1                              |             
      Clear Cell Focus                     |                                                    X        X            |             
      Clear Cell Focus, Multiple           |                                                          X               |             
      Hepatodiaphragmatic Nodule           |                         X                 X                              |             
      Vacuolization Cytoplasmic            |                                                                      2   |             

                                            __________________________________________________________________________|             
   Mesentery                               |    +                             +                                       |             
      Fat, Necrosis                        |    2                             3                                       |             

                                            __________________________________________________________________________|             
   Oral Mucosa                             |                                                             +            |             

                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Acinus, Atrophy                      |                                                                          |             

                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Erosion                              |                         2                                                |             
      Inflammation, Suppurative            |       1              2              1                                    |             
      Ulcer                                |                      4  4                                                |             
      Epithelium, Hyperplasia              |       1                             2           1                        |             

                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

                                            __________________________________________________________________________|             
   Tooth                                   |                                              +                           |             
      Degeneration                         |                                              3                           |             

 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Blood Vessel                            | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +|             
      Inflammation                         |                                                                          |             

                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Myocardium, Fibrosis                 |                                                                          |             

 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |    1                                                                     |             
      Vacuolization Cytoplasmic            | 1                          2  2                                      3   |             

                                            __________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |       1                                                                  |             

 _____________________________________________________________________________________________________________________|             
NTP Experiment-Test: 05184-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           GLUTARALDEHYDE                                      Date: 09/14/98  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 08:29:41  
                                                                                                                                    

 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 7| 7| 5| 4| 5| 4| 1| 7| 7| 7| 3| 7| 7| 1| 7| 7| 5| 7| 5| 7| 7| 5| 0|             
                             DAY ON TEST   | 3| 3| 1| 3| 1| 3| 6| 7| 1| 3| 3| 3| 7| 0| 1| 1| 0| 3| 6| 3| 1| 3| 3| 1| 3|             
                                           | 0| 0| 6| 0| 4| 2| 9| 4| 3| 1| 1| 0| 5| 8| 8| 7| 2| 0| 7| 0| 2| 0| 0| 6| 2|             

 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
    750 PPB                                | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             

 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  M  +  +  +  M  +  +  M  M  +  +  M  +  +  +  +  M  +  +  +|             

                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                                                          |             
      Hemorrhage                           |             4                                                            |             
      Pars Distalis, Hyperplasia           |                                           2              3               |             

                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      C-Cell, Hyperplasia                  |    1                                                                     |             

 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Tissue NOS                              |          +                                                               |             

 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Clitoral Gland                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                  4                                       |             
      Inflammation, Suppurative            |                                  4                                       |             

                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |       3                          2                                       |             
      Cyst, Multiple                       |                3                                                         |             

                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                                                          |             

 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

                                            __________________________________________________________________________|             
   Lymph Node                              |                                                                          |             

                                            __________________________________________________________________________|             
   Lymph Node, Bronchial                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +|             

                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  M  +  +  +  M  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +|             

                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrosis                             |                                                                          |             

                                            __________________________________________________________________________|             
   Lymph Node, Mediastinal                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Accessory Spleen                     |                                                                          |             
      Fibrosis                             |                            3                                             |             
      Hemorrhage                           |             3                                                            |             

                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                                                4         |             

                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Suppurative            |                                                                          |             

 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

 _____________________________________________________________________________________________________________________|             
NTP Experiment-Test: 05184-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           GLUTARALDEHYDE                                      Date: 09/14/98  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 08:29:41  
                                                                                                                                    

 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 7| 7| 5| 4| 5| 4| 1| 7| 7| 7| 3| 7| 7| 1| 7| 7| 5| 7| 5| 7| 7| 5| 0|             
                             DAY ON TEST   | 3| 3| 1| 3| 1| 3| 6| 7| 1| 3| 3| 3| 7| 0| 1| 1| 0| 3| 6| 3| 1| 3| 3| 1| 3|             
                                           | 0| 0| 6| 0| 4| 2| 9| 4| 3| 1| 1| 0| 5| 8| 8| 7| 2| 0| 7| 0| 2| 0| 0| 6| 2|             

 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
    750 PPB                                | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             

 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM - cont             |                                                                          |             
                                           |                                                                          |             
      Sternum, Cyst                        |                                  3                                       |             

 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |                                                                          |             
      Hydrocephalus                        |                                                                2         |             

                                            __________________________________________________________________________|             
   Spinal Cord                             |                         +                                                |             
      Demyelination                        |                         2                                                |             

 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Larynx                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Foreign Body                         |             X                                         X              X  X|             
      Epiglottis, Inflammation, Suppurative|    2                                                                     |             
      Epiglottis, Metaplasia, Squamous     |                                                                          |             
      Glands, Inflammation                 |    2        2     1  1                 1           2  2  1        1  1   |             

                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic                |                                                                          |             
      Alveolar Epithelium, Hyperplasia     |       1     1     1                                                      |             
      Alveolus, Emphysema                  |                      1                                                   |             
      Alveolus, Infiltration Cellular,     |                                                                          |             
           Histiocyte                      | 1  1  4  2  1     2  1     1  2  2     1  1  1  1     1  1     1  2  1   |             
      Alveolus, Inflammation, Suppurative  |                                                                1         |             
      Interstitium, Fibrosis               | 1     3  2                 1  1  1     1  1           1  1     1  1      |             

                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Goblet Cell, Respiratory Epithelium, |                                                                          |             
           Hyperplasia                     |    2           3                                      1     2            |             
      Nasolacrimal Duct, Inflammation      |                                                                          |             
      Olfactory Epithelium, Atrophy        |                         2                                                |             
      Olfactory Epithelium, Degeneration,  |                                                                          |             
           Hyaline                         | 1     1        2  1        1  1  1                             1         |             
      Respiratory Epithelium, Hyperplasia  | 2  2     1  2     3  2  2           2  2  1     2  1     1               |             
      Respiratory Epithelium, Inflammation | 3  2  2  2  3     4  3  3  1  1     3  3  2     3  3  3  1        1  2  1|             
      Respiratory Epithelium, Metaplasia,  |                                                                          |             
           Squamous                        | 3  2        2     2  2  3              3                                 |             
      Squamous Epithelium, Hyperplasia     | 2  2  3  2  3     3  3  3  2  2     3  3  4  1  3  4  3  3        2  2  2|             
      Squamous Epithelium, Inflammation    | 3  2  4  2  4  2  4  4  4  2  3  1  2  4  4  1  4  4  4  3     1  2  3  3|             

                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Suppurative            |                                                                          |             

 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             

 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

 _____________________________________________________________________________________________________________________|             
NTP Experiment-Test: 05184-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           GLUTARALDEHYDE                                      Date: 09/14/98  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 08:29:41  
                                                                                                                                    

 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 7| 7| 5| 4| 5| 4| 1| 7| 7| 7| 3| 7| 7| 1| 7| 7| 5| 7| 5| 7| 7| 5| 0|             
                             DAY ON TEST   | 3| 3| 1| 3| 1| 3| 6| 7| 1| 3| 3| 3| 7| 0| 1| 1| 0| 3| 6| 3| 1| 3| 3| 1| 3|             
                                           | 0| 0| 6| 0| 4| 2| 9| 4| 3| 1| 1| 0| 5| 8| 8| 7| 2| 0| 7| 0| 2| 0| 0| 6| 2|             

 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
    750 PPB                                | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             

 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
      Cyst                                 |                                                                          |             
      Nephropathy, Chronic                 |    1  4  2  1  1  1  1     1  2  2  1  3  1     3  2  1  1        2  1   |             

                                            __________________________________________________________________________|             
   Urethra                                 |                                                                   +      |             

                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

 _____________________________________________________________________________________________________________________|             
NTP Experiment-Test: 05184-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           GLUTARALDEHYDE                                      Date: 09/14/98  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 08:29:41  
                                                                                                                                    

 __________________________________________________________________________________________________________________________________ 
                                           | 7| 6| 1| 7| 7| 7| 4| 6| 1| 7| 1| 6| 5| 6| 6| 4| 2| 7| 7| 5| 6| 6| 6| 7| 6|            |
                             DAY ON TEST   | 3| 2| 1| 3| 3| 1| 7| 8| 0| 3| 0| 5| 8| 4| 5| 6| 5| 1| 2| 2| 5| 7| 9| 3| 5|            |
                                           | 0| 8| 3| 1| 1| 6| 4| 0| 8| 0| 6| 4| 3| 1| 4| 3| 3| 7| 1| 8| 4| 7| 8| 0| 2|      T (*) |

 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|      A     |
    750 PPB                                | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |

 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +|  49        |

                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Diverticulum                         |                                                                          |      1     |
      Parasite Metazoan                    |                                                                          |      1  2.0|

                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +|  49        |

                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Parasite Metazoan                    |                                                                          |      3  1.0|

                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +|  49        |

                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +|  47        |

                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +|  48        |

                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Basophilic Focus                     |                                                                   X      |      1     |
      Basophilic Focus, Multiple           |                                                                          |      2  1.0|
      Clear Cell Focus                     |                   X                                                      |      3     |
      Clear Cell Focus, Multiple           |                                                                          |      1     |
      Hepatodiaphragmatic Nodule           |                      X                                                   |      3     |
      Vacuolization Cytoplasmic            |                                     3                       3            |      3  2.7|

                                            __________________________________________________________________________|____________|
   Mesentery                               |                                                       +                  |   3        |
      Fat, Necrosis                        |                                                       3                  |      3  2.7|

                                            __________________________________________________________________________|____________|
   Oral Mucosa                             |                                                                          |   1        |

                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Acinus, Atrophy                      |          2                 3     1  2                                    |      4  2.0|

                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |

                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Erosion                              |                                                                          |      1  2.0|
      Inflammation, Suppurative            |                                     3                                    |      4  1.8|
      Ulcer                                |                                                                          |      2  4.0|
      Epithelium, Hyperplasia              |                                     3                       2            |      5  1.8|

                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |

                                            __________________________________________________________________________|____________|
   Tooth                                   |       +                       +                                          |   3        |
      Degeneration                         |       3                                                                  |      2  3.0|

 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Blood Vessel                            | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Inflammation                         |                                                 4                        |      1  4.0|

                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Myocardium, Fibrosis                 |                                                                      1   |      1  1.0|

 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |

 __________________________________________________________________________________________________________________________________ 

  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
NTP Experiment-Test: 05184-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           GLUTARALDEHYDE                                      Date: 09/14/98  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 08:29:41  
                                                                                                                                    

 __________________________________________________________________________________________________________________________________ 
                                           | 7| 6| 1| 7| 7| 7| 4| 6| 1| 7| 1| 6| 5| 6| 6| 4| 2| 7| 7| 5| 6| 6| 6| 7| 6|            |
                             DAY ON TEST   | 3| 2| 1| 3| 3| 1| 7| 8| 0| 3| 0| 5| 8| 4| 5| 6| 5| 1| 2| 2| 5| 7| 9| 3| 5|            |
                                           | 0| 8| 3| 1| 1| 6| 4| 0| 8| 0| 6| 4| 3| 1| 4| 3| 3| 7| 1| 8| 4| 7| 8| 0| 2|      T (*) |

 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|      A     |
    750 PPB                                | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |

 __________________________________________________________________________________________________________________________________ 
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +|  49        |
      Hemorrhage                           |                                                                          |      1  1.0|
      Vacuolization Cytoplasmic            |          1  2                    2  3                                1   |      9  1.9|

                                            __________________________________________________________________________|____________|
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +|  49        |
      Hyperplasia                          |                                                                          |      1  1.0|

                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |

                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | M  +  +  +  +  +  +  M  M  M  M  M  M  +  +  M  +  +  +  +  +  +  +  +  +|  36        |

                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +|  49        |
      Cyst                                 |    2                                                              2      |      2  2.0|
      Hemorrhage                           |                                                                          |      1  4.0|
      Pars Distalis, Hyperplasia           |    4                 3                                         1  3  3   |      7  2.7|

                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +|  49        |
      C-Cell, Hyperplasia                  |          1                    1                    4                     |      4  1.8|

 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Tissue NOS                              |                                                                          |   1        |

 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Clitoral Gland                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia                          |                                                       4                  |      2  4.0|
      Inflammation, Suppurative            |                                                                          |      1  4.0|

                                            __________________________________________________________________________|____________|
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +|  49        |
      Cyst                                 |             2                                                            |      3  2.3|
      Cyst, Multiple                       |                                                                          |      1  3.0|

                                            __________________________________________________________________________|____________|
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cyst                                 |          4                                                               |      1  4.0|

 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |

                                            __________________________________________________________________________|____________|
   Lymph Node                              |                                                                +     +   |   2        |

                                            __________________________________________________________________________|____________|
   Lymph Node, Bronchial                   | +  +  +  +  M  +  +  M  M  +  +  M  +  +  +  M  M  +  M  +  +  +  +  +  +|  42        |

                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  46        |

                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Fibrosis                             |                                  2                                       |      1  2.0|

                                            __________________________________________________________________________|____________|
   Lymph Node, Mediastinal                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +|  49        |

                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Accessory Spleen                     |    X                                                                     |      1     |
      Fibrosis                             |    3  3     3                                                            |      4  3.0|
      Hemorrhage                           |                                                                          |      1  3.0|

 __________________________________________________________________________________________________________________________________ 

  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
NTP Experiment-Test: 05184-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           GLUTARALDEHYDE                                      Date: 09/14/98  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 08:29:41  
                                                                                                                                    

 __________________________________________________________________________________________________________________________________ 
                                           | 7| 6| 1| 7| 7| 7| 4| 6| 1| 7| 1| 6| 5| 6| 6| 4| 2| 7| 7| 5| 6| 6| 6| 7| 6|            |
                             DAY ON TEST   | 3| 2| 1| 3| 3| 1| 7| 8| 0| 3| 0| 5| 8| 4| 5| 6| 5| 1| 2| 2| 5| 7| 9| 3| 5|            |
                                           | 0| 8| 3| 1| 1| 6| 4| 0| 8| 0| 6| 4| 3| 1| 4| 3| 3| 7| 1| 8| 4| 7| 8| 0| 2|      T (*) |

 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|      A     |
    750 PPB                                | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |

 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +|  49        |

 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia                          |                                                                          |      1  4.0|

                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inflammation, Suppurative            |                                                          2               |      1  2.0|

 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Sternum, Cyst                        |                                                                          |      1  3.0|

 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hemorrhage                           |                                  3     2                       3         |      3  2.7|
      Hydrocephalus                        |                                                       2                  |      2  2.0|

                                            __________________________________________________________________________|____________|
   Spinal Cord                             |       +                 +     +                                          |   4        |
      Demyelination                        |                         2                                                |      2  2.0|

 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Larynx                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +|  49        |
      Foreign Body                         |       X                                   X                              |      6     |
      Epiglottis, Inflammation, Suppurative|       2              4                                         2     2   |      5  2.4|
      Epiglottis, Metaplasia, Squamous     |                                     2                                    |      1  2.0|
      Glands, Inflammation                 |    1  3              2              2     2                 1  2     1  1|     19  1.5|

                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  I  +  +  +  +  +  +  +  +  +|  49        |
      Inflammation, Chronic                |                3                                                         |      1  3.0|
      Alveolar Epithelium, Hyperplasia     |                                        4                                 |      4  1.8|
      Alveolus, Emphysema                  |                                                    1                     |      2  1.0|
      Alveolus, Infiltration Cellular,     |                                                                          |            |
           Histiocyte                      | 2  3     2  3  3     1     1     2        3        1  2     1  1  2  2  1|     35  1.6|
      Alveolus, Inflammation, Suppurative  |                                                                          |      1  1.0|
      Interstitium, Fibrosis               | 1        1  2  2                 1        2        2  2        1  2  2  1|     24  1.4|

                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +|  49        |
      Goblet Cell, Respiratory Epithelium, |                                                                          |            |
           Hyperplasia                     |             1  2           1                                            1|      8  1.6|
      Nasolacrimal Duct, Inflammation      |                                                                      2   |      1  2.0|
      Olfactory Epithelium, Atrophy        |                                           2                              |      2  2.0|
      Olfactory Epithelium, Degeneration,  |                                                                          |            |

 __________________________________________________________________________________________________________________________________ 

  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
NTP Experiment-Test: 05184-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           GLUTARALDEHYDE                                      Date: 09/14/98  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 08:29:41  
                                                                                                                                    

 __________________________________________________________________________________________________________________________________ 
                                           | 7| 6| 1| 7| 7| 7| 4| 6| 1| 7| 1| 6| 5| 6| 6| 4| 2| 7| 7| 5| 6| 6| 6| 7| 6|            |
                             DAY ON TEST   | 3| 2| 1| 3| 3| 1| 7| 8| 0| 3| 0| 5| 8| 4| 5| 6| 5| 1| 2| 2| 5| 7| 9| 3| 5|            |
                                           | 0| 8| 3| 1| 1| 6| 4| 0| 8| 0| 6| 4| 3| 1| 4| 3| 3| 7| 1| 8| 4| 7| 8| 0| 2|      T (*) |

 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|      A     |
    750 PPB                                | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |

 __________________________________________________________________________________________________________________________________ 
 RESPIRATORY SYSTEM - cont                 |                                                                          |            |
                                           |                                                                          |            |
           Hyaline                         |    1     1        1              1                 1  1           1      |     15  1.1|
      Respiratory Epithelium, Hyperplasia  | 2     3     1  2  1  3     2        2     2        2  3  2  2  2  2     2|     29  1.9|
      Respiratory Epithelium, Inflammation | 3  2  2     2  3  3  4  2  2     2  3  2  3     1  4  3  3  3  3  3  2  2|     42  2.5|
      Respiratory Epithelium, Metaplasia,  |                                                                          |            |
           Squamous                        | 2                    3              3              2  2  1  2  2  2      |     16  2.3|
      Squamous Epithelium, Hyperplasia     | 3  3  3  2  3  4  2  4  4  2  3  3  3  2  3     3  3  2  3  3  2  2  3  3|     45  2.7|
      Squamous Epithelium, Inflammation    | 4  3  4  2  4  4  4  4  4  3  4  4  4  2  4     4  4  3  4  4  3  3  4  2|     48  3.2|

                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inflammation, Suppurative            |                                                                         1|      1  1.0|

 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |

 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cyst                                 |                                                             2            |      1  2.0|
      Nephropathy, Chronic                 |    1     2  4  1  1              2     3  2           3  1  2  1  1     2|     33  1.7|

                                            __________________________________________________________________________|____________|
   Urethra                                 |                                                                          |   1        |

                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |

 __________________________________________________________________________________________________________________________________ 

  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
NTP Experiment-Test: 05184-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           GLUTARALDEHYDE                                      Date: 09/14/98  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 08:29:41  
                                                                                                                                    

 _____________________________________________________________________________________________________________________              
                                           | 5| 6| 7| 1| 4| 7| 7| 3| 4| 6| 7| 5| 7| 5| 5| 5| 6| 7| 6| 7| 7| 6| 7| 6| 6|             
                             DAY ON TEST   | 4| 1| 0| 1| 9| 0| 2| 9| 9| 1| 2| 0| 0| 5| 5| 8| 0| 1| 3| 2| 2| 5| 2| 8| 8|             
                                           | 4| 2| 8| 7| 5| 8| 9| 2| 8| 2| 9| 2| 2| 6| 5| 0| 1| 7| 7| 9| 9| 2| 9| 9| 9|             

 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    CONTROL                                | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             

 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Foreign Body                         |    4                                                                     |             
      Ulcer                                |    4                                                                     |             

                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A|             
      Parasite Metazoan                    |                                                 2                        |             
      Muscularis, Mineralization           |                               2                                          |             

                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A|             
      Parasite Metazoan                    | 1     1                 1                                                |             

                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A|             

                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A|             
      Inflammation, Focal, Suppurative     |                3                                                         |             

                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                                             3            |             
      Basophilic Focus                     |                                        X                                 |             
      Hepatodiaphragmatic Nodule           |                                              X                           |             
      Inflammation, Suppurative            |                                                                          |             
      Necrosis                             |                                                                          |             
      Thrombosis                           |                                     4                                    |             
      Vacuolization Cytoplasmic            |    4  3     3  3  3                 3                                    |             
      Bile Duct, Hyperplasia               |                                                             2            |             
      Hepatocyte, Degeneration, Focal      |                                                                   2     3|             
      Hepatocyte, Hyperplasia              |                                                                          |             

                                            __________________________________________________________________________|             
   Mesentery                               |                +  +           +     +                                    |             
      Fat, Necrosis                        |                3  4           2     3                                    |             

                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                                                          |             
      Hemorrhage                           |                                                                          |             
      Acinus, Atrophy                      |                1              3                                1         |             

                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Suppurative            |    3                                         1                           |             
      Mineralization                       |                4                                                        3|             
      Ulcer                                |    4                                4                                    |             
      Epithelium, Hyperplasia              |    3           4                             2     2                     |             

                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Erosion                              |                                                                          |             
      Epithelium, Mineralization           |    1           3  3           3                                      3  3|             

                                            __________________________________________________________________________|             
   Tongue                                  |                               +                                          |             

                                            __________________________________________________________________________|             
   Tooth                                   |          +                                                               |             
      Degeneration                         |          1                                                               |             

 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             

 _____________________________________________________________________________________________________________________|             
NTP Experiment-Test: 05184-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           GLUTARALDEHYDE                                      Date: 09/14/98  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 08:29:41  
                                                                                                                                    

 _____________________________________________________________________________________________________________________              
                                           | 5| 6| 7| 1| 4| 7| 7| 3| 4| 6| 7| 5| 7| 5| 5| 5| 6| 7| 6| 7| 7| 6| 7| 6| 6|             
                             DAY ON TEST   | 4| 1| 0| 1| 9| 0| 2| 9| 9| 1| 2| 0| 0| 5| 5| 8| 0| 1| 3| 2| 2| 5| 2| 8| 8|             
                                           | 4| 2| 8| 7| 5| 8| 9| 2| 8| 2| 9| 2| 2| 6| 5| 0| 1| 7| 7| 9| 9| 2| 9| 9| 9|             

 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    CONTROL                                | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             

 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Blood Vessel                            |                +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation                         |                               4                                          |             
      Mineralization                       |                4  4           4                                         4|             

                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Mineralization                       |                4  3           4                                         4|             
      Atrium, Thrombosis                   |                            2        4                                    |             
      Myocardium, Fibrosis                 |    1           4  2           3        1  1        1           2        4|             
      Valve, Thrombosis                    | 1                                                                        |             

 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |                                                                          |             
      Vacuolization Cytoplasmic            |    2  2  2  3                 2     2                                    |             

                                            __________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                   4                       1  1     1                    1|             
      Bilateral, Hyperplasia               |                2                                                         |             

                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                           2                              |             

                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  M  M  +  +  +  +  +  +  +  +  M  +  M  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                2  2                                                  2  3|             

                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |             2                                                           4|             
      Hemorrhage                           |                                                                          |             
      Pars Distalis, Hyperplasia           |                               1           2                              |             

                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      C-Cell, Hyperplasia                  |                1                                                         |             

 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Tissue NOS                              |                                  +                                       |             

 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Spermatocele                         |                                                                          |             

                                            __________________________________________________________________________|             
   Preputial Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Suppurative            |                                                                          |             

                                            __________________________________________________________________________|             
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation                         |                               3        3                 3               |             

                                            __________________________________________________________________________|             
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Suppurative            |                                                                          |             

                                            __________________________________________________________________________|             
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Arteriole, Inflammation              |                                        3                                 |             
      Bilateral, Interstitial Cell,        |                                                                          |             
          Hyperplasia                      | 2     2     2                                         1                  |             
      Germinal Epithelium, Atrophy         |                4  4           4     4     4        3        3  3         |             

 _____________________________________________________________________________________________________________________|             
NTP Experiment-Test: 05184-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           GLUTARALDEHYDE                                      Date: 09/14/98  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 08:29:41  
                                                                                                                                    

 _____________________________________________________________________________________________________________________              
                                           | 5| 6| 7| 1| 4| 7| 7| 3| 4| 6| 7| 5| 7| 5| 5| 5| 6| 7| 6| 7| 7| 6| 7| 6| 6|             
                             DAY ON TEST   | 4| 1| 0| 1| 9| 0| 2| 9| 9| 1| 2| 0| 0| 5| 5| 8| 0| 1| 3| 2| 2| 5| 2| 8| 8|             
                                           | 4| 2| 8| 7| 5| 8| 9| 2| 8| 2| 9| 2| 2| 6| 5| 0| 1| 7| 7| 9| 9| 2| 9| 9| 9|             

 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    CONTROL                                | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             

 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             

 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrosis                             |                4  2                       2        3                 3  3|             

                                            __________________________________________________________________________|             
   Lymph Node                              |                                                                          |             

                                            __________________________________________________________________________|             
   Lymph Node, Bronchial                   | M  +  I  +  +  +  +  +  +  +  +  +  +  M  +  M  +  M  +  M  M  +  +  +  M|             
      Fibrosis                             |                1                                                         |             

                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  M  +  +  +  +  +  +  +|             

                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

                                            __________________________________________________________________________|             
   Lymph Node, Mediastinal                 | M  M  +  +  +  +  I  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |                                                                          |             

                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrosis                             |                   2                 4                    3  3  3         |             

                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Mammary Gland                           | +  I  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Galactocele                          |                                                          4               |             

                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst Epithelial Inclusion            |                                                                          |             
      Hyperplasia                          |                                                                          |             

 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Tibia, Fracture                      |          X                                                               |             

                                            __________________________________________________________________________|             
   Skeletal Muscle                         |                                                                          |             

 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |                         2                                                |             
      Hydrocephalus                        |                      4           4     4                                 |             

 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Larynx                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Foreign Body                         |                                                                          |             
      Epiglottis, Inflammation, Suppurative|                                     2                                    |             
      Glands, Inflammation                 |    1  1     1  2        1                 1           1  1     1  2     2|             
      Squamous Epithelium, Hyperplasia     |                                                                          |             

                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Alveolar Epithelium, Hyperplasia     |                1           2              4        2                     |             
      Alveolus, Emphysema                  |                               4                                          |             
      Alveolus, Hemorrhage                 |                   2                                                      |             
      Alveolus, Infiltration Cellular,     |                                                                          |             
           Histiocyte                      |                2  2  1     2  1  1  1     1        1     1     1     1   |             

 _____________________________________________________________________________________________________________________|             
NTP Experiment-Test: 05184-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           GLUTARALDEHYDE                                      Date: 09/14/98  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 08:29:41  
                                                                                                                                    

 _____________________________________________________________________________________________________________________              
                                           | 5| 6| 7| 1| 4| 7| 7| 3| 4| 6| 7| 5| 7| 5| 5| 5| 6| 7| 6| 7| 7| 6| 7| 6| 6|             
                             DAY ON TEST   | 4| 1| 0| 1| 9| 0| 2| 9| 9| 1| 2| 0| 0| 5| 5| 8| 0| 1| 3| 2| 2| 5| 2| 8| 8|             
                                           | 4| 2| 8| 7| 5| 8| 9| 2| 8| 2| 9| 2| 2| 6| 5| 0| 1| 7| 7| 9| 9| 2| 9| 9| 9|             

 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    CONTROL                                | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             

 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
      Alveolus, Mineralization             |                               2                                         3|             
      Interstitium, Fibrosis               |                1  2                                                      |             

                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Foreign Body                         |                                                                          |             
      Goblet Cell, Respiratory Epithelium, |                                                                          |             
           Hyperplasia                     |             1                                                            |             
      Olfactory Epithelium, Degeneration,  |                                                                          |             
           Hyaline                         |                                        1                                 |             
      Olfactory Epithelium, Foreign Body   |                                                                         X|             
      Olfactory Epithelium, Inflammation   |                                                                         4|             
      Respiratory Epithelium, Hyperplasia  |                1              1                                          |             
      Respiratory Epithelium, Inflammation | 1              2  3        2  2                       3                 2|             
      Respiratory Epithelium, Metaplasia,  |                                                                          |             
           Squamous                        |                2                                                         |             
      Squamous Epithelium, Foreign Body    |                                                                          |             
      Squamous Epithelium, Hyperplasia     |                                                                          |             
      Squamous Epithelium, Inflammation    |                                        1                                 |             

                                            __________________________________________________________________________|             
   Pleura                                  |    +                 +                                                   |             
      Inflammation, Suppurative            |    3                                                                     |             

                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Eye                                     |                                                                          |             
      Cataract                             |                                                                          |             

                                            __________________________________________________________________________|             
   Zymbal's Gland                          |                                                                +         |             

 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Mineralization                       |                4  3                                                     4|             
      Nephropathy, Chronic                 | 3  4  3     2  4  4  3  3     4  2  4  4  4  4  3  4     4  2  4  4  4  4|             
      Papilla, Transitional Epithelium,    |                                                                          |             
           Hyperplasia                     |                                                                          |             
      Pelvis, Dilatation                   |                                                                          |             
      Pelvis, Inflammation, Suppurative    |                                                                          |             
      Renal Tubule, Atrophy                |                                                                          |             
      Renal Tubule, Atypia Cellular        |                               3                                          |             
      Renal Tubule, Regeneration           |                4                                                         |             

                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Suppurative            |                                                                          |             
      Transitional Epithelium, Hyperplasia |                                                                          |             

 _____________________________________________________________________________________________________________________|             
NTP Experiment-Test: 05184-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           GLUTARALDEHYDE                                      Date: 09/14/98  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 08:29:41  
                                                                                                                                    

 __________________________________________________________________________________________________________________________________ 
                                           | 7| 6| 6| 6| 6| 4| 6| 7| 7| 7| 5| 6| 7| 6| 7| 5| 6| 7| 5| 6| 5| 6| 7| 7| 6|            |
                             DAY ON TEST   | 2| 0| 5| 9| 1| 5| 5| 2| 2| 2| 1| 3| 2| 9| 0| 8| 7| 2| 8| 0| 4| 3| 1| 2| 5|            |
                                           | 9| 2| 2| 4| 7| 2| 2| 9| 9| 9| 4| 7| 9| 4| 2| 3| 6| 9| 3| 2| 3| 8| 7| 9| 7|      T (*) |

 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      A     |
    CONTROL                                | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |

 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Foreign Body                         |                                                                          |      1  4.0|
      Ulcer                                |                                                                          |      1  4.0|

                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Parasite Metazoan                    |                                                                      2   |      2  2.0|
      Muscularis, Mineralization           |                                                                          |      1  2.0|

                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |

                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  A  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  47        |
      Parasite Metazoan                    |                                                                          |      3  1.0|

                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |

                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +|  47        |

                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  A  +  A  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +|  46        |
      Inflammation, Focal, Suppurative     |                                                                          |      1  3.0|

                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Angiectasis                          |    1                                                                     |      2  2.0|
      Basophilic Focus                     |                                                                          |      1     |
      Hepatodiaphragmatic Nodule           |                                                                          |      1     |
      Inflammation, Suppurative            |          1                                                               |      1  1.0|
      Necrosis                             |                                                                         2|      1  2.0|
      Thrombosis                           |                                                                          |      1  4.0|
      Vacuolization Cytoplasmic            |                                                                         3|      7  3.1|
      Bile Duct, Hyperplasia               |       3                                                        3         |      3  2.7|
      Hepatocyte, Degeneration, Focal      |                                                                3         |      3  2.7|
      Hepatocyte, Hyperplasia              |                                     2                                    |      1  2.0|

                                            __________________________________________________________________________|____________|
   Mesentery                               |          +           +                       +  +        +              +|  10        |
      Fat, Necrosis                        |                      2                       2           2              2|      8  2.5|

                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Angiectasis                          |       4                                                                  |      1  4.0|
      Hemorrhage                           |       3                                                                  |      1  3.0|
      Acinus, Atrophy                      |       3                 3        2           2  2           2            |      9  2.1|

                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |

                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Inflammation, Suppurative            | 3  3              2  2                                2                 4|      8  2.5|
      Mineralization                       |                                           2                       3      |      4  3.0|
      Ulcer                                |    4                                4                                   4|      5  4.0|
      Epithelium, Hyperplasia              |    2     2        2  2                                1  2              3|     11  2.3|

                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Erosion                              |                                                                   3      |      1  3.0|
      Epithelium, Mineralization           |                      2                    3                       3      |      9  2.7|

 __________________________________________________________________________________________________________________________________ 

  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
NTP Experiment-Test: 05184-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           GLUTARALDEHYDE                                      Date: 09/14/98  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 08:29:41  
                                                                                                                                    

 __________________________________________________________________________________________________________________________________ 
                                           | 7| 6| 6| 6| 6| 4| 6| 7| 7| 7| 5| 6| 7| 6| 7| 5| 6| 7| 5| 6| 5| 6| 7| 7| 6|            |
                             DAY ON TEST   | 2| 0| 5| 9| 1| 5| 5| 2| 2| 2| 1| 3| 2| 9| 0| 8| 7| 2| 8| 0| 4| 3| 1| 2| 5|            |
                                           | 9| 2| 2| 4| 7| 2| 2| 9| 9| 9| 4| 7| 9| 4| 2| 3| 6| 9| 3| 2| 3| 8| 7| 9| 7|      T (*) |

 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      A     |
    CONTROL                                | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |

 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Tongue                                  |                                                                          |   1        |

                                            __________________________________________________________________________|____________|
   Tooth                                   |                                                                          |   1        |
      Degeneration                         |                                                                          |      1  1.0|

 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Blood Vessel                            | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  45        |
      Inflammation                         |                                                                          |      1  4.0|
      Mineralization                       |                      3                    4                       4      |      7  3.9|

                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Mineralization                       |                                           3                       4      |      6  3.7|
      Atrium, Thrombosis                   |                                                 2                        |      3  2.7|
      Myocardium, Fibrosis                 |    1     2                                3                              |     12  2.1|
      Valve, Thrombosis                    |                                                                          |      1  1.0|

 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hemorrhage                           |                                           3                              |      1  3.0|
      Vacuolization Cytoplasmic            |       1     1        2                                                   |      9  1.9|

                                            __________________________________________________________________________|____________|
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia                          | 4  2  1                                   2        4           2        4|     12  2.3|
      Bilateral, Hyperplasia               |                                                                          |      1  2.0|

                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia                          |                                                                          |      1  2.0|

                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +  +  +  M  +  M  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  M  +|  42        |
      Hyperplasia                          |                                           3                       2     4|      7  2.6|

                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cyst                                 |                                                                          |      2  3.0|
      Hemorrhage                           | 3                                                                        |      1  3.0|
      Pars Distalis, Hyperplasia           | 2                 4        3     1                                       |      6  2.2|

                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      C-Cell, Hyperplasia                  |    1  1                                   1                 2     3      |      6  1.5|

 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Tissue NOS                              |                                                                          |   1        |

 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Spermatocele                         |                                                                      4   |      1  4.0|

                                            __________________________________________________________________________|____________|
   Preputial Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |

 __________________________________________________________________________________________________________________________________ 

  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
NTP Experiment-Test: 05184-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           GLUTARALDEHYDE                                      Date: 09/14/98  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 08:29:41  
                                                                                                                                    

 __________________________________________________________________________________________________________________________________ 
                                           | 7| 6| 6| 6| 6| 4| 6| 7| 7| 7| 5| 6| 7| 6| 7| 5| 6| 7| 5| 6| 5| 6| 7| 7| 6|            |
                             DAY ON TEST   | 2| 0| 5| 9| 1| 5| 5| 2| 2| 2| 1| 3| 2| 9| 0| 8| 7| 2| 8| 0| 4| 3| 1| 2| 5|            |
                                           | 9| 2| 2| 4| 7| 2| 2| 9| 9| 9| 4| 7| 9| 4| 2| 3| 6| 9| 3| 2| 3| 8| 7| 9| 7|      T (*) |

 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      A     |
    CONTROL                                | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |

 __________________________________________________________________________________________________________________________________ 
 GENITAL SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
      Inflammation, Suppurative            |                      3                    3              4  3     3      |      5  3.2|

                                            __________________________________________________________________________|____________|
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inflammation                         |                      2                 4           4        4     2  4   |      9  3.2|

                                            __________________________________________________________________________|____________|
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inflammation, Suppurative            |                      1                 4           4                     |      3  3.0|

                                            __________________________________________________________________________|____________|
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Arteriole, Inflammation              |                                                                          |      1  3.0|
      Bilateral, Interstitial Cell,        |                                                                          |            |
          Hyperplasia                      |                                                                          |      4  1.8|
      Germinal Epithelium, Atrophy         |                   3                       3        3     4               |     12  3.5|

 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Fibrosis                             |                      2                                                   |      7  2.7|

                                            __________________________________________________________________________|____________|
   Lymph Node                              |             +                                                            |   1        |

                                            __________________________________________________________________________|____________|
   Lymph Node, Bronchial                   | M  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  M  +  +  +  +  +  +  +  +|  39        |
      Fibrosis                             |                                                                          |      1  1.0|

                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  47        |

                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |

                                            __________________________________________________________________________|____________|
   Lymph Node, Mediastinal                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  47        |
      Hemorrhage                           |          2                                                               |      1  2.0|

                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Fibrosis                             |    3  2     3     3  3              3  2           3  2     3            |     15  2.8|

                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |

 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Galactocele                          |                                              2                           |      2  3.0|

                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cyst Epithelial Inclusion            |             X                                                        X   |      2     |
      Hyperplasia                          | 2                                                                        |      1  2.0|

 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Tibia, Fracture                      |                                                                          |      1     |

                                            __________________________________________________________________________|____________|
   Skeletal Muscle                         |                               +                                          |   1        |

 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |

 __________________________________________________________________________________________________________________________________ 

  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
NTP Experiment-Test: 05184-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           GLUTARALDEHYDE                                      Date: 09/14/98  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 08:29:41  
                                                                                                                                    

 __________________________________________________________________________________________________________________________________ 
                                           | 7| 6| 6| 6| 6| 4| 6| 7| 7| 7| 5| 6| 7| 6| 7| 5| 6| 7| 5| 6| 5| 6| 7| 7| 6|            |
                             DAY ON TEST   | 2| 0| 5| 9| 1| 5| 5| 2| 2| 2| 1| 3| 2| 9| 0| 8| 7| 2| 8| 0| 4| 3| 1| 2| 5|            |
                                           | 9| 2| 2| 4| 7| 2| 2| 9| 9| 9| 4| 7| 9| 4| 2| 3| 6| 9| 3| 2| 3| 8| 7| 9| 7|      T (*) |

 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      A     |
    CONTROL                                | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |

 __________________________________________________________________________________________________________________________________ 
 NERVOUS SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
      Hemorrhage                           |                1                                         1               |      3  1.3|
      Hydrocephalus                        |                                        2     4                           |      5  3.6|

 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Larynx                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Foreign Body                         |                      X                                                   |      1     |
      Epiglottis, Inflammation, Suppurative|                                                                          |      1  2.0|
      Glands, Inflammation                 | 1  1           1  1  4     2  1  2  2  1  1     1  2  1  1     1        1|     28  1.4|
      Squamous Epithelium, Hyperplasia     |                                           2                              |      1  2.0|

                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Alveolar Epithelium, Hyperplasia     |          2                       4                       1     1     4   |      9  2.3|
      Alveolus, Emphysema                  |                                                                          |      1  4.0|
      Alveolus, Hemorrhage                 |                                  1        3                              |      3  2.0|
      Alveolus, Infiltration Cellular,     |                                                                          |            |
           Histiocyte                      |       2     1        1  1        2  3     1           1  1  1        1   |     23  1.3|
      Alveolus, Mineralization             |                                           3                       4      |      4  3.0|
      Interstitium, Fibrosis               |             1        1  1        1  2                 1                  |      8  1.3|

                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Foreign Body                         |                            X                                         X   |      2     |
      Goblet Cell, Respiratory Epithelium, |                                                                          |            |
           Hyperplasia                     |                                                                          |      1  1.0|
      Olfactory Epithelium, Degeneration,  |                                                                          |            |
           Hyaline                         |          1  1                                                  1         |      4  1.0|
      Olfactory Epithelium, Foreign Body   |                                                                          |      1     |
      Olfactory Epithelium, Inflammation   |                                                                          |      1  4.0|
      Respiratory Epithelium, Hyperplasia  |             4        2                 2                    2            |      6  2.0|
      Respiratory Epithelium, Inflammation | 1           4        2     3        1  2  2        1        2        3   |     17  2.1|
      Respiratory Epithelium, Metaplasia,  |                                                                          |            |
           Squamous                        |                                                                          |      1  2.0|
      Squamous Epithelium, Foreign Body    |       X                                                                  |      1     |
      Squamous Epithelium, Hyperplasia     |                      2                    2                       2      |      3  2.0|
      Squamous Epithelium, Inflammation    |       2              3  1                 3                       2      |      6  2.0|

                                            __________________________________________________________________________|____________|
   Pleura                                  |                                                                          |   2        |
      Inflammation, Suppurative            |                                                                          |      1  3.0|

                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |

 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Eye                                     |          +                                                               |   1        |
      Cataract                             |          4                                                               |      1  4.0|

 __________________________________________________________________________________________________________________________________ 

  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
NTP Experiment-Test: 05184-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           GLUTARALDEHYDE                                      Date: 09/14/98  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 08:29:41  
                                                                                                                                    

 __________________________________________________________________________________________________________________________________ 
                                           | 7| 6| 6| 6| 6| 4| 6| 7| 7| 7| 5| 6| 7| 6| 7| 5| 6| 7| 5| 6| 5| 6| 7| 7| 6|            |
                             DAY ON TEST   | 2| 0| 5| 9| 1| 5| 5| 2| 2| 2| 1| 3| 2| 9| 0| 8| 7| 2| 8| 0| 4| 3| 1| 2| 5|            |
                                           | 9| 2| 2| 4| 7| 2| 2| 9| 9| 9| 4| 7| 9| 4| 2| 3| 6| 9| 3| 2| 3| 8| 7| 9| 7|      T (*) |

 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      A     |
    CONTROL                                | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |

 __________________________________________________________________________________________________________________________________ 
 SPECIAL SENSES SYSTEM - cont              |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Zymbal's Gland                          |                                                                          |   1        |

 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Mineralization                       |                                                                          |      3  3.7|
      Nephropathy, Chronic                 | 4  4     2  4     4  4  4     4     4  3  4  3  2  4  2  4  3  2  4  4  4|     43  3.5|
      Papilla, Transitional Epithelium,    |                                                                          |            |
           Hyperplasia                     | 4                                                                        |      1  4.0|
      Pelvis, Dilatation                   |          4                                                               |      1  4.0|
      Pelvis, Inflammation, Suppurative    | 4                                                                        |      1  4.0|
      Renal Tubule, Atrophy                |          4                                                               |      1  4.0|
      Renal Tubule, Atypia Cellular        |                                                                          |      1  3.0|
      Renal Tubule, Regeneration           |                                                                          |      1  4.0|

                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inflammation, Suppurative            |    3                                                                     |      1  3.0|
      Transitional Epithelium, Hyperplasia |    2                                                        3            |      2  2.5|

 __________________________________________________________________________________________________________________________________ 

  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
NTP Experiment-Test: 05184-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           GLUTARALDEHYDE                                      Date: 09/14/98  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 08:29:41  
                                                                                                                                    

 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 6| 7| 7| 6| 7| 6| 5| 5| 6| 7| 7| 7| 7| 6| 7| 6| 6| 7| 7| 7| 7| 5| 6|             
                             DAY ON TEST   | 2| 2| 4| 2| 2| 2| 0| 5| 5| 3| 1| 2| 2| 1| 2| 6| 1| 9| 3| 1| 2| 2| 2| 7| 8|             
                                           | 4| 5| 7| 9| 9| 1| 8| 4| 0| 3| 3| 9| 9| 2| 9| 6| 6| 4| 2| 2| 9| 9| 9| 9| 9|             

 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    250 PPB                                | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             

 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Parasite Metazoan                    |       2                                                                  |             

                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Parasite Metazoan                    |                                  1                                       |             

                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Parasite Metazoan                    |                                                                          |             

                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |       4                                                                  |             
      Basophilic Focus                     |                                                                   X      |             
      Clear Cell Focus                     |                                     X     X  X                           |             
      Hepatodiaphragmatic Nodule           |                                           X                              |             
      Necrosis                             |                         4                                                |             
      Vacuolization Cytoplasmic            |                                                                          |             

                                            __________________________________________________________________________|             
   Mesentery                               |                         +                       +        +     +        +|             
      Fat, Necrosis                        |                         3                       3              2        2|             

                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Acinus, Atrophy                      |                                           1                       3      |             

                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Suppurative            |                         4                    3                           |             
      Mineralization                       |                                                                      4   |             
      Ulcer                                | 4                       4                    4              4            |             
      Epithelium, Hyperplasia              |                                                                         4|             

                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Suppurative            |                                                                         2|             
      Ulcer                                |                      4  4                                                |             
      Epithelium, Mineralization           |                                                                      4   |             

                                            __________________________________________________________________________|             
   Tongue                                  |                                                                          |             
      Hyperkeratosis                       |                                                                          |             

 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Blood Vessel                            | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation                         |                                                                          |             
      Mineralization                       |                                                                      4   |             

                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Mineralization                       |                                                                      4   |             
      Atrium, Thrombosis                   |                                                                          |             
      Myocardium, Fibrosis                 |    2     1                    2                                   3      |             

 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             

 _____________________________________________________________________________________________________________________|             
NTP Experiment-Test: 05184-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           GLUTARALDEHYDE                                      Date: 09/14/98  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 08:29:41  
                                                                                                                                    

 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 6| 7| 7| 6| 7| 6| 5| 5| 6| 7| 7| 7| 7| 6| 7| 6| 6| 7| 7| 7| 7| 5| 6|             
                             DAY ON TEST   | 2| 2| 4| 2| 2| 2| 0| 5| 5| 3| 1| 2| 2| 1| 2| 6| 1| 9| 3| 1| 2| 2| 2| 7| 8|             
                                           | 4| 5| 7| 9| 9| 1| 8| 4| 0| 3| 3| 9| 9| 2| 9| 6| 6| 4| 2| 2| 9| 9| 9| 9| 9|             

 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    250 PPB                                | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             

 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Vacuolization Cytoplasmic            |          1                                      1                        |             

                                            __________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |             2  3                                   2           3  2      |             

                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  M  +  M  +  M  M  +  +  M  M  +  +  +  M  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                                                         3|             

                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +|             
      Cyst                                 |                                           2                              |             
      Pars Distalis, Hyperplasia           |                                     3  3           3                     |             

                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      C-Cell, Hyperplasia                  | 1        2                                                               |             

 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Tissue NOS                              |                               +           +                              |             

 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Coagulating Gland                       |                                                                +         |             

                                            __________________________________________________________________________|             
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation                         |                                                                          |             

                                            __________________________________________________________________________|             
   Preputial Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                                                          |             
      Inflammation, Suppurative            | 4                                                              3         |             

                                            __________________________________________________________________________|             
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                                                          |             
      Inflammation                         |    4  2                                2                                 |             

                                            __________________________________________________________________________|             
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Suppurative            |                                                 3                        |             

                                            __________________________________________________________________________|             
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Germinal Epithelium, Atrophy         |    4  4        4  4                    4     4           3               |             

 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrosis                             |                                                                      3   |             

                                            __________________________________________________________________________|             
   Lymph Node                              |                      +     +                                             |             

                                            __________________________________________________________________________|             
   Lymph Node, Bronchial                   | M  M  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  M  +  +|             
      Fibrosis                             |                                              1                           |             

                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  M  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +|             

                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

                                            __________________________________________________________________________|             
   Lymph Node, Mediastinal                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrosis                             |    3                       3                    3     3  3  3  3         |             
      Hematopoietic Cell Proliferation     |                                                                          |             
      Hemorrhage                           |                                                                          |             

 _____________________________________________________________________________________________________________________|             
NTP Experiment-Test: 05184-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           GLUTARALDEHYDE                                      Date: 09/14/98  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 08:29:41  
                                                                                                                                    

 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 6| 7| 7| 6| 7| 6| 5| 5| 6| 7| 7| 7| 7| 6| 7| 6| 6| 7| 7| 7| 7| 5| 6|             
                             DAY ON TEST   | 2| 2| 4| 2| 2| 2| 0| 5| 5| 3| 1| 2| 2| 1| 2| 6| 1| 9| 3| 1| 2| 2| 2| 7| 8|             
                                           | 4| 5| 7| 9| 9| 1| 8| 4| 0| 3| 3| 9| 9| 2| 9| 6| 6| 4| 2| 2| 9| 9| 9| 9| 9|             

 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    250 PPB                                | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             

 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Infarct                              |                                                                          |             

                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Galactocele                          |                                                                          |             

                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst Epithelial Inclusion            |                                                                          |             
      Ulcer                                |                                                                          |             

 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |       3              4                 3                                 |             
      Hydrocephalus                        |       3           3                             3                        |             

 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Larynx                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Foreign Body                         |                                              X                    X      |             
      Glands, Inflammation                 |             1                    1           1  1  1  2     2     1     1|             

                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Alveolar Epithelium, Hyperplasia     |                                                                          |             
      Alveolus, Hemorrhage                 |                                                                          |             
      Alveolus, Infiltration Cellular,     |                                                                          |             
           Histiocyte                      |                               1        2  1  1  3           1            |             
      Alveolus, Inflammation, Suppurative  |                                        2                                 |             
      Alveolus, Metaplasia, Osseous        |                                                 1                        |             
      Alveolus, Mineralization             |                                                                      3   |             
      Interstitium, Fibrosis               |                               1        2        1           1        1   |             

                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Foreign Body                         |                            X                                             |             
      Nasolacrimal Duct, Inflammation      |       3                                                                 2|             
      Olfactory Epithelium, Degeneration,  |                                                                          |             
           Hyaline                         |       1        1           2                                1        1  2|             
      Olfactory Epithelium, Hyperplasia    |                                                                         2|             
      Olfactory Epithelium, Inflammation   |                                                                         3|             
      Respiratory Epithelium, Hyperplasia  |                         3                       2                        |             
      Respiratory Epithelium, Inflammation |    1                    2                       2                    1   |             
      Respiratory Epithelium, Metaplasia,  |                                                                          |             
           Squamous                        |                                                 2                        |             
      Squamous Epithelium, Hyperplasia     |       2           2        1  2                 2        2               |             
      Squamous Epithelium, Inflammation    |    1  1           2        1  2     1           2        1           2   |             

 _____________________________________________________________________________________________________________________|             
NTP Experiment-Test: 05184-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           GLUTARALDEHYDE                                      Date: 09/14/98  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 08:29:41  
                                                                                                                                    

 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 6| 7| 7| 6| 7| 6| 5| 5| 6| 7| 7| 7| 7| 6| 7| 6| 6| 7| 7| 7| 7| 5| 6|             
                             DAY ON TEST   | 2| 2| 4| 2| 2| 2| 0| 5| 5| 3| 1| 2| 2| 1| 2| 6| 1| 9| 3| 1| 2| 2| 2| 7| 8|             
                                           | 4| 5| 7| 9| 9| 1| 8| 4| 0| 3| 3| 9| 9| 2| 9| 6| 6| 4| 2| 2| 9| 9| 9| 9| 9|             

 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    250 PPB                                | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             

 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Mineralization                       |                                                                          |             

 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Eye                                     |                                           +     +                        |             
      Cataract                             |                                           3     2                        |             

                                            __________________________________________________________________________|             
   Lacrimal Gland                          |                                                                          |             

                                            __________________________________________________________________________|             
   Zymbal's Gland                          |                                                                          |             

 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                                                          |             
      Infarct                              |                                                                          |             
      Mineralization                       |                                                                      4   |             
      Nephropathy, Chronic                 | 4  4  4  4  3  4  2  2  4  2  3  4  3  3  2  4  4  4  2  3  4  3  2  4  4|             
      Papilla, Transitional Epithelium,    |                                                                          |             
           Hyperplasia                     |                                                             3            |             

                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

 _____________________________________________________________________________________________________________________|             
NTP Experiment-Test: 05184-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           GLUTARALDEHYDE                                      Date: 09/14/98  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 08:29:41  
                                                                                                                                    

 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 3| 5| 4| 6| 6| 7| 6| 7| 6| 6| 6| 6| 6| 7| 6| 7| 6| 7| 4| 7| 5| 6|            |
                             DAY ON TEST   | 2| 2| 0| 5| 7| 4| 7| 3| 2| 1| 2| 0| 9| 5| 3| 7| 0| 6| 2| 9| 2| 9| 1| 6| 1|            |
                                           | 9| 9| 8| 6| 7| 9| 5| 4| 9| 5| 9| 7| 4| 2| 8| 1| 8| 6| 9| 4| 9| 5| 2| 9| 7|      T (*) |

 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|      A     |
    250 PPB                                | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |

 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |

                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Parasite Metazoan                    |                         2     2                                          |      3  2.0|

                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Parasite Metazoan                    | 1     1                                               1                  |      4  1.0|

                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  A  A  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +|  46        |
      Parasite Metazoan                    |                                                       1                  |      1  1.0|

                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  A  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  47        |

                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  A  A  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +|  46        |

                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  A  A  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +|  46        |

                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Angiectasis                          |                         3                                                |      2  3.5|
      Basophilic Focus                     |                                                                          |      1     |
      Clear Cell Focus                     | X                                                                        |      4     |
      Hepatodiaphragmatic Nodule           |                                              X                           |      2     |
      Necrosis                             |                                     4                                    |      2  4.0|
      Vacuolization Cytoplasmic            |                                                          3               |      1  3.0|

                                            __________________________________________________________________________|____________|
   Mesentery                               |    +                       +                                             |   7        |
      Fat, Necrosis                        |    3                       3                                             |      6  2.7|

                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Acinus, Atrophy                      |                                                       4                  |      3  2.7|

                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |

                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Inflammation, Suppurative            |                                     2                                    |      3  3.0|
      Mineralization                       |                                                                          |      1  4.0|
      Ulcer                                |       4              4                                   4               |      7  4.0|
      Epithelium, Hyperplasia              |                                                    2                     |      2  3.0|

                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Inflammation, Suppurative            |                                                                          |      1  2.0|
      Ulcer                                |                                                                          |      2  4.0|
      Epithelium, Mineralization           |                   4                 4  4  4                              |      5  4.0|

                                            __________________________________________________________________________|____________|
   Tongue                                  |                   +     +                                                |   2        |
      Hyperkeratosis                       |                         2                                                |      1  2.0|

 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Blood Vessel                            | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inflammation                         |                   4                    4                                 |      2  4.0|
      Mineralization                       |                                     4     4                              |      3  4.0|

                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |

 __________________________________________________________________________________________________________________________________ 

  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
NTP Experiment-Test: 05184-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           GLUTARALDEHYDE                                      Date: 09/14/98  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 08:29:41  
                                                                                                                                    

 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 3| 5| 4| 6| 6| 7| 6| 7| 6| 6| 6| 6| 6| 7| 6| 7| 6| 7| 4| 7| 5| 6|            |
                             DAY ON TEST   | 2| 2| 0| 5| 7| 4| 7| 3| 2| 1| 2| 0| 9| 5| 3| 7| 0| 6| 2| 9| 2| 9| 1| 6| 1|            |
                                           | 9| 9| 8| 6| 7| 9| 5| 4| 9| 5| 9| 7| 4| 2| 8| 1| 8| 6| 9| 4| 9| 5| 2| 9| 7|      T (*) |

 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|      A     |
    250 PPB                                | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |

 __________________________________________________________________________________________________________________________________ 
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |            |
                                           |                                                                          |            |
      Mineralization                       |                                        4                                 |      2  4.0|
      Atrium, Thrombosis                   |             3                                                  3         |      2  3.0|
      Myocardium, Fibrosis                 |                   2     2           2  3  3                 1            |     10  2.1|

 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Vacuolization Cytoplasmic            |             2                 3                       1           2      |      6  1.7|

                                            __________________________________________________________________________|____________|
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia                          |       3                       4           3                             2|      9  2.7|

                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |

                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  M  M  +  +  +  M  M  +  +  M  +  +  +  +  +|  38        |
      Hyperplasia                          | 4        4        3                 3  3  3                              |      7  3.3|

                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Cyst                                 |                                              2                           |      2  2.0|
      Pars Distalis, Hyperplasia           |                      4                 4                                 |      5  3.4|

                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      C-Cell, Hyperplasia                  |                                                                          |      2  1.5|

 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Tissue NOS                              |                                                                          |   2        |

 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Coagulating Gland                       |                                                                   +      |   2        |

                                            __________________________________________________________________________|____________|
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inflammation                         |                   3                                                      |      1  3.0|

                                            __________________________________________________________________________|____________|
   Preputial Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia                          |                      4                                                   |      1  4.0|
      Inflammation, Suppurative            |                                                                          |      2  3.5|

                                            __________________________________________________________________________|____________|
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia                          |                                                             2            |      1  2.0|
      Inflammation                         |                                                                3         |      4  2.8|

                                            __________________________________________________________________________|____________|
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inflammation, Suppurative            |                                                                          |      1  3.0|

                                            __________________________________________________________________________|____________|
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Germinal Epithelium, Atrophy         |          4                    4                                          |      9  3.9|

 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Fibrosis                             |          4        3                 2  2                                 |      5  2.8|

 __________________________________________________________________________________________________________________________________ 

  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
NTP Experiment-Test: 05184-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           GLUTARALDEHYDE                                      Date: 09/14/98  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 08:29:41  
                                                                                                                                    

 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 3| 5| 4| 6| 6| 7| 6| 7| 6| 6| 6| 6| 6| 7| 6| 7| 6| 7| 4| 7| 5| 6|            |
                             DAY ON TEST   | 2| 2| 0| 5| 7| 4| 7| 3| 2| 1| 2| 0| 9| 5| 3| 7| 0| 6| 2| 9| 2| 9| 1| 6| 1|            |
                                           | 9| 9| 8| 6| 7| 9| 5| 4| 9| 5| 9| 7| 4| 2| 8| 1| 8| 6| 9| 4| 9| 5| 2| 9| 7|      T (*) |

 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|      A     |
    250 PPB                                | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |

 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Lymph Node                              |                      +                          +                        |   4        |

                                            __________________________________________________________________________|____________|
   Lymph Node, Bronchial                   | +  +  +  +  +  +  +  +  M  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  M|  42        |
      Fibrosis                             |                                                                          |      1  1.0|

                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |

                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |

                                            __________________________________________________________________________|____________|
   Lymph Node, Mediastinal                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |

                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Fibrosis                             | 3  3  4        3              2  4  2                 3                  |     15  3.0|
      Hematopoietic Cell Proliferation     |                                                                         2|      1  2.0|
      Hemorrhage                           |                                                                      3   |      1  3.0|
      Infarct                              |                   4  4                          4                        |      3  4.0|

                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |

 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Galactocele                          |                         4                                                |      1  4.0|

                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cyst Epithelial Inclusion            |                      X  X                                                |      2     |
      Ulcer                                |                                        4                                 |      1  4.0|

 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |

 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hemorrhage                           |                                  4                                       |      4  3.5|
      Hydrocephalus                        |                         3  2                       3     2               |      7  2.7|

 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Larynx                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Foreign Body                         |                                                                          |      2     |
      Glands, Inflammation                 | 1     1     2        1           2        2           1        1        2|     18  1.3|

                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Alveolar Epithelium, Hyperplasia     |                                        1              3                 1|      3  1.7|
      Alveolus, Hemorrhage                 |       2                                                              4   |      2  3.0|
      Alveolus, Infiltration Cellular,     |                                                                          |            |
           Histiocyte                      |                   2     1           1  1     1  1           1     2     1|     15  1.3|
      Alveolus, Inflammation, Suppurative  |    1                                                                     |      2  1.5|
      Alveolus, Metaplasia, Osseous        |                                                                          |      1  1.0|

 __________________________________________________________________________________________________________________________________ 

  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
NTP Experiment-Test: 05184-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           GLUTARALDEHYDE                                      Date: 09/14/98  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 08:29:41  
                                                                                                                                    

 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 3| 5| 4| 6| 6| 7| 6| 7| 6| 6| 6| 6| 6| 7| 6| 7| 6| 7| 4| 7| 5| 6|            |
                             DAY ON TEST   | 2| 2| 0| 5| 7| 4| 7| 3| 2| 1| 2| 0| 9| 5| 3| 7| 0| 6| 2| 9| 2| 9| 1| 6| 1|            |
                                           | 9| 9| 8| 6| 7| 9| 5| 4| 9| 5| 9| 7| 4| 2| 8| 1| 8| 6| 9| 4| 9| 5| 2| 9| 7|      T (*) |

 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|      A     |
    250 PPB                                | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |

 __________________________________________________________________________________________________________________________________ 
 RESPIRATORY SYSTEM - cont                 |                                                                          |            |
                                           |                                                                          |            |
      Alveolus, Mineralization             |                                        4  1                              |      3  2.7|
      Interstitium, Fibrosis               |    1              1     1           1        1  2           1     2     1|     14  1.2|

                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Foreign Body                         |                                                          X               |      2     |
      Nasolacrimal Duct, Inflammation      |                                                                         2|      3  2.3|
      Olfactory Epithelium, Degeneration,  |                                                                          |            |
           Hyaline                         |                                              1                       1   |      8  1.3|
      Olfactory Epithelium, Hyperplasia    |                                                                          |      1  2.0|
      Olfactory Epithelium, Inflammation   |                                                                          |      1  3.0|
      Respiratory Epithelium, Hyperplasia  |    2                 2                          1                        |      5  2.0|
      Respiratory Epithelium, Inflammation |    1           1     2                    1     1        3               |     10  1.5|
      Respiratory Epithelium, Metaplasia,  |                                                                          |            |
           Squamous                        |                                                 1                        |      2  1.5|
      Squamous Epithelium, Hyperplasia     |                      1              1     1     2                 2      |     11  1.6|
      Squamous Epithelium, Inflammation    |                1  1  2              2  1  1     3                 1      |     17  1.5|

                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Mineralization                       |                                        4                                 |      1  4.0|

 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Eye                                     |                                                          +               |   3        |
      Cataract                             |                                                          1               |      3  2.0|

                                            __________________________________________________________________________|____________|
   Lacrimal Gland                          |                                                                      +   |   1        |

                                            __________________________________________________________________________|____________|
   Zymbal's Gland                          |                   +                    +                    +            |   3        |

 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cyst                                 |          4                                                        3      |      2  3.5|
      Infarct                              |                                                 4                        |      1  4.0|
      Mineralization                       |                                                                          |      1  4.0|
      Nephropathy, Chronic                 | 4  4  2  4  2  1  4  3  4  2  4     4  4  4  3  3  4  3  2  3  1  4     2|     48  3.2|
      Papilla, Transitional Epithelium,    |                                                                          |            |
           Hyperplasia                     |                                                                          |      1  3.0|

                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |

 __________________________________________________________________________________________________________________________________ 

  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
NTP Experiment-Test: 05184-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           GLUTARALDEHYDE                                      Date: 09/14/98  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 08:29:41  
                                                                                                                                    

 _____________________________________________________________________________________________________________________              
                                           | 5| 6| 5| 6| 4| 6| 5| 7| 6| 7| 6| 7| 6| 7| 5| 6| 3| 6| 6| 7| 5| 6| 5| 7| 7|             
                             DAY ON TEST   | 6| 1| 8| 5| 8| 3| 2| 0| 0| 1| 8| 2| 5| 0| 1| 6| 6| 8| 6| 2| 9| 1| 2| 2| 2|             
                                           | 1| 7| 7| 2| 1| 8| 6| 8| 8| 6| 8| 9| 6| 5| 2| 4| 5| 2| 6| 6| 3| 7| 6| 9| 9|             

 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    500 PPB                                | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             

 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Mineralization                       |                                                                          |             

                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Parasite Metazoan                    |                                  1                                       |             

                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Parasite Metazoan                    |                                     1                          1         |             

                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  A  +  +  +  +  +  +  +  +  +  A  +  +  A  +  +  +  +  +  +  +  +  +|             

                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  A  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +|             

                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                                          3               |             
      Clear Cell Focus                     |    X                                                                     |             
      Clear Cell Focus, Multiple           |                                  X                                       |             
      Necrosis                             |                            3                                             |             
      Vacuolization Cytoplasmic            |                   3                                                      |             

                                            __________________________________________________________________________|             
   Mesentery                               |                                              +           +  +           +|             
      Hemorrhage                           |                                                                         3|             
      Thrombosis                           |                                                                          |             
      Fat, Necrosis                        |                                              2           4  3            |             

                                            __________________________________________________________________________|             
   Oral Mucosa                             |                               +                                          |             

                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Acinus, Atrophy                      |             1                                                            |             

                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Suppurative            |                                                             4            |             
      Mineralization                       |                                                                          |             
      Ulcer                                |                                        4                                 |             
      Epithelium, Hyperplasia              |                                                                          |             

                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Erosion                              |                                        4                                 |             
      Inflammation, Suppurative            |                                                             3            |             
      Epithelium, Mineralization           |                            2                                            2|             
      Epithelium, Necrosis                 |                                                          1               |             

 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Blood Vessel                            | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Mineralization                       |                                                                          |             

                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Mineralization                       |                                                                          |             
      Atrium, Thrombosis                   |                                                 4                        |             
      Myocardium, Fibrosis                 |                   2                 2                 2                 2|             
      Myocardium, Ventricle, Hypertrophy   |                                                 2                        |             

 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             

 _____________________________________________________________________________________________________________________|             
NTP Experiment-Test: 05184-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           GLUTARALDEHYDE                                      Date: 09/14/98  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 08:29:41  
                                                                                                                                    

 _____________________________________________________________________________________________________________________              
                                           | 5| 6| 5| 6| 4| 6| 5| 7| 6| 7| 6| 7| 6| 7| 5| 6| 3| 6| 6| 7| 5| 6| 5| 7| 7|             
                             DAY ON TEST   | 6| 1| 8| 5| 8| 3| 2| 0| 0| 1| 8| 2| 5| 0| 1| 6| 6| 8| 6| 2| 9| 1| 2| 2| 2|             
                                           | 1| 7| 7| 2| 1| 8| 6| 8| 8| 6| 8| 9| 6| 5| 2| 4| 5| 2| 6| 6| 3| 7| 6| 9| 9|             

 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    500 PPB                                | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             

 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Accessory Adrenal Cortical Nodule    |                                                                         1|             
      Vacuolization Cytoplasmic            |                         2              3                 3           1   |             

                                            __________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                      1                          3              2         |             

                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                                                          |             

                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                                                          |             

                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |          3                                                               |             
      Hemorrhage                           |       4                                                                  |             
      Pars Distalis, Hyperplasia           |                            3     2                                       |             

                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      C-Cell, Hyperplasia                  |             2              4                       3     1              1|             
      Follicular Cell, Hyperplasia         |                            3                                             |             

 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             

 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Coagulating Gland                       |                                                                          |             

                                            __________________________________________________________________________|             
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

                                            __________________________________________________________________________|             
   Preputial Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                           2                              |             
      Hyperplasia                          |                                                       4     3            |             
      Inflammation, Suppurative            |                               4                       3     4            |             

                                            __________________________________________________________________________|             
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                                                      1   |             
      Inflammation                         | 3                                                        2     2         |             

                                            __________________________________________________________________________|             
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

                                            __________________________________________________________________________|             
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Bilateral, Interstitial Cell,        |                                                                          |             
          Hyperplasia                      |                                                                          |             
      Germinal Epithelium, Atrophy         |                   4        3           4                                3|             

 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrosis                             |                                                          2               |             

                                            __________________________________________________________________________|             
   Lymph Node                              |                                                                          |             

                                            __________________________________________________________________________|             
   Lymph Node, Bronchial                   | +  +  +  M  +  +  +  +  +  +  M  M  +  +  +  +  +  M  +  +  +  +  +  +  M|             

                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                                                          |             

 _____________________________________________________________________________________________________________________|             
NTP Experiment-Test: 05184-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           GLUTARALDEHYDE                                      Date: 09/14/98  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 08:29:41  
                                                                                                                                    

 _____________________________________________________________________________________________________________________              
                                           | 5| 6| 5| 6| 4| 6| 5| 7| 6| 7| 6| 7| 6| 7| 5| 6| 3| 6| 6| 7| 5| 6| 5| 7| 7|             
                             DAY ON TEST   | 6| 1| 8| 5| 8| 3| 2| 0| 0| 1| 8| 2| 5| 0| 1| 6| 6| 8| 6| 2| 9| 1| 2| 2| 2|             
                                           | 1| 7| 7| 2| 1| 8| 6| 8| 8| 6| 8| 9| 6| 5| 2| 4| 5| 2| 6| 6| 3| 7| 6| 9| 9|             

 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    500 PPB                                | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             

 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

                                            __________________________________________________________________________|             
   Lymph Node, Mediastinal                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrosis                             | 4        4     4           4  4  4     4     3        3     4            |             
      Hemorrhage                           |                                                                          |             

                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Galactocele                          |                         2                                                |             

                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |       4              3  1           3        4              4            |             
      Hydrocephalus                        |    1        2           3              2  4                              |             
      Mineralization                       |                                                                          |             

 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Larynx                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Foreign Body                         |                   X                                         X            |             
      Glands, Inflammation                 |    2  1  1        3                    1     2        1  1  3  1        1|             
      Squamous Epithelium, Hyperplasia     |                                                                          |             

                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Mineralization                       |                         4                                                |             
      Alveolar Epithelium, Hyperplasia     | 2           1  2                       2                                 |             
      Alveolus, Hemorrhage                 | 2                                                                        |             
      Alveolus, Infiltration Cellular,     |                                                                          |             
           Histiocyte                      |    2        2  3        2  3           4           1  1  1  3     3      |             
      Alveolus, Metaplasia, Osseous        |                         4                                                |             
      Alveolus, Mineralization             |                                                                          |             
      Bronchiole, Hyperplasia              |                                        3                                 |             
      Bronchiole, Inflammation, Suppurative|                                                                          |             
      Interstitium, Fibrosis               | 1  1        1  2        3  2           4           1  2  1  2     3      |             

                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Foreign Body                         |                                              X                           |             
      Goblet Cell, Respiratory Epithelium, |                                                                          |             
           Hyperplasia                     |                2                 2                          2            |             
      Olfactory Epithelium, Degeneration,  |                                                                          |             
           Hyaline                         | 1              1                             1                       1  1|             
      Olfactory Epithelium, Foreign Body   |                                                                          |             

 _____________________________________________________________________________________________________________________|             
NTP Experiment-Test: 05184-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           GLUTARALDEHYDE                                      Date: 09/14/98  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 08:29:41  
                                                                                                                                    

 _____________________________________________________________________________________________________________________              
                                           | 5| 6| 5| 6| 4| 6| 5| 7| 6| 7| 6| 7| 6| 7| 5| 6| 3| 6| 6| 7| 5| 6| 5| 7| 7|             
                             DAY ON TEST   | 6| 1| 8| 5| 8| 3| 2| 0| 0| 1| 8| 2| 5| 0| 1| 6| 6| 8| 6| 2| 9| 1| 2| 2| 2|             
                                           | 1| 7| 7| 2| 1| 8| 6| 8| 8| 6| 8| 9| 6| 5| 2| 4| 5| 2| 6| 6| 3| 7| 6| 9| 9|             

 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    500 PPB                                | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             

 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
      Olfactory Epithelium, Inflammation   |                                                                          |             
      Respiratory Epithelium, Hyperplasia  |                         1  2           4     3        2  2        1  2   |             
      Respiratory Epithelium, Inflammation |    1        2           2  2     1  1  4  2  2        2  4           2   |             
      Respiratory Epithelium, Metaplasia,  |                                                                          |             
           Squamous                        |                                  2     3              2  3        1      |             
      Squamous Epithelium, Hyperplasia     | 2  1  2  2  2  3     1  2  2  2  2  2  3     2  2     2  3  2  2  2  2  1|             
      Squamous Epithelium, Inflammation    | 2  1  2  2  3  3     2  2  4  2  2  2  4     3  2  2  3  4  3  3  2  2   |             

                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Eye                                     |             +                                         +                  |             
      Cataract                             |             2                                         1                  |             
      Inflammation, Suppurative            |                                                                          |             

                                            __________________________________________________________________________|             
   Zymbal's Gland                          |                                                                          |             

 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                                             3            |             
      Nephropathy, Chronic                 | 2  4     4  3  4  3  3  4  4  3  3  1  3  3  3     1  4  4  2  3  1  4  4|             

                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Transitional Epithelium, Hyperplasia |                                        2                                 |             

 _____________________________________________________________________________________________________________________|             
NTP Experiment-Test: 05184-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           GLUTARALDEHYDE                                      Date: 09/14/98  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 08:29:41  
                                                                                                                                    

 __________________________________________________________________________________________________________________________________ 
                                           | 6| 5| 7| 7| 7| 7| 7| 6| 6| 5| 7| 7| 6| 7| 6| 7| 5| 6| 6| 3| 6| 6| 5| 6| 6|            |
                             DAY ON TEST   | 1| 3| 2| 2| 1| 0| 2| 8| 5| 2| 2| 2| 5| 2| 8| 2| 2| 8| 6| 9| 0| 8| 8| 4| 3|            |
                                           | 2| 3| 1| 9| 1| 2| 9| 9| 4| 5| 9| 9| 2| 9| 6| 9| 4| 9| 1| 3| 9| 8| 1| 5| 2|      T (*) |

 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|      A     |
    500 PPB                                | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |

 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |

                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +|  48        |
      Mineralization                       |                                                                         4|      1  4.0|

                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +|  49        |
      Parasite Metazoan                    |                   1                                                      |      2  1.0|

                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  A  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Parasite Metazoan                    |    1              1           1  1           1  1  1                     |      9  1.0|

                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +|  48        |

                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  A  +  +  +  +  A  +  +  +  +  A  +  A  +  +  +  +  +  +  +  +|  43        |

                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  A  +  +  +  +  A  +  +  +  +  A  +  A  +  +  +  +  +  +  +  +|  44        |

                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Angiectasis                          |                                                                          |      1  3.0|
      Clear Cell Focus                     |                                                                          |      1     |
      Clear Cell Focus, Multiple           |                X                                                         |      2     |
      Necrosis                             |                                                                          |      1  3.0|
      Vacuolization Cytoplasmic            |                            3                                             |      2  3.0|

                                            __________________________________________________________________________|____________|
   Mesentery                               |    +                                                                    +|   6        |
      Hemorrhage                           |                                                                          |      1  3.0|
      Thrombosis                           |    4                                                                     |      1  4.0|
      Fat, Necrosis                        |    4                                                                    3|      5  3.2|

                                            __________________________________________________________________________|____________|
   Oral Mucosa                             |                                                                          |   1        |

                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Acinus, Atrophy                      |       2                                                                  |      2  1.5|

                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |

                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inflammation, Suppurative            | 2              3                                                         |      3  3.0|
      Mineralization                       |                                                                         4|      1  4.0|
      Ulcer                                |                4                                      4           4      |      4  4.0|
      Epithelium, Hyperplasia              |                            4                          2                  |      2  3.0|

                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Erosion                              |                                                                          |      1  4.0|
      Inflammation, Suppurative            |                                                                          |      1  3.0|
      Epithelium, Mineralization           |                                                                         4|      3  2.7|
      Epithelium, Necrosis                 |                                                                          |      1  1.0|

 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Blood Vessel                            | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Mineralization                       |                                                                         4|      1  4.0|

                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |

 __________________________________________________________________________________________________________________________________ 

  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
NTP Experiment-Test: 05184-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           GLUTARALDEHYDE                                      Date: 09/14/98  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 08:29:41  
                                                                                                                                    

 __________________________________________________________________________________________________________________________________ 
                                           | 6| 5| 7| 7| 7| 7| 7| 6| 6| 5| 7| 7| 6| 7| 6| 7| 5| 6| 6| 3| 6| 6| 5| 6| 6|            |
                             DAY ON TEST   | 1| 3| 2| 2| 1| 0| 2| 8| 5| 2| 2| 2| 5| 2| 8| 2| 2| 8| 6| 9| 0| 8| 8| 4| 3|            |
                                           | 2| 3| 1| 9| 1| 2| 9| 9| 4| 5| 9| 9| 2| 9| 6| 9| 4| 9| 1| 3| 9| 8| 1| 5| 2|      T (*) |

 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|      A     |
    500 PPB                                | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |

 __________________________________________________________________________________________________________________________________ 
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |            |
                                           |                                                                          |            |
      Mineralization                       |                                                                         4|      1  4.0|
      Atrium, Thrombosis                   |                                                                          |      1  4.0|
      Myocardium, Fibrosis                 |                                           3     3  2                 2   |      8  2.3|
      Myocardium, Ventricle, Hypertrophy   |                                                                          |      1  2.0|

 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Accessory Adrenal Cortical Nodule    |                                                                          |      1  1.0|
      Vacuolization Cytoplasmic            |                   3     2                                         3     2|      8  2.4|

                                            __________________________________________________________________________|____________|
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia                          | 1                    3                                         3         |      6  2.2|

                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia                          |                                              2                           |      1  2.0|

                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +  +  +  +  M  +  +  M  +  M  +  +  +  M  +  +  +  +  +  +  +  +  +|  45        |
      Hyperplasia                          |                                                       2                  |      1  2.0|

                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cyst                                 |                                                                          |      1  3.0|
      Hemorrhage                           |                                              4     4                     |      3  4.0|
      Pars Distalis, Hyperplasia           |    3                    2                                                |      4  2.5|

                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      C-Cell, Hyperplasia                  |          2              2              2                                 |      8  2.1|
      Follicular Cell, Hyperplasia         |                                                                          |      1  3.0|

 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |

 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Coagulating Gland                       |                   +                                                      |   1        |

                                            __________________________________________________________________________|____________|
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |

                                            __________________________________________________________________________|____________|
   Preputial Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cyst                                 |                                                                          |      1  2.0|
      Hyperplasia                          |                                                                          |      2  3.5|
      Inflammation, Suppurative            |                                                                          |      3  3.7|

                                            __________________________________________________________________________|____________|
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia                          |             1                                                            |      2  1.0|
      Inflammation                         |                                        3                       2         |      5  2.4|

                                            __________________________________________________________________________|____________|
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |

                                            __________________________________________________________________________|____________|
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Bilateral, Interstitial Cell,        |                                                                          |            |

 __________________________________________________________________________________________________________________________________ 

  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
NTP Experiment-Test: 05184-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           GLUTARALDEHYDE                                      Date: 09/14/98  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 08:29:41  
                                                                                                                                    

 __________________________________________________________________________________________________________________________________ 
                                           | 6| 5| 7| 7| 7| 7| 7| 6| 6| 5| 7| 7| 6| 7| 6| 7| 5| 6| 6| 3| 6| 6| 5| 6| 6|            |
                             DAY ON TEST   | 1| 3| 2| 2| 1| 0| 2| 8| 5| 2| 2| 2| 5| 2| 8| 2| 2| 8| 6| 9| 0| 8| 8| 4| 3|            |
                                           | 2| 3| 1| 9| 1| 2| 9| 9| 4| 5| 9| 9| 2| 9| 6| 9| 4| 9| 1| 3| 9| 8| 1| 5| 2|      T (*) |

 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|      A     |
    500 PPB                                | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |

 __________________________________________________________________________________________________________________________________ 
 GENITAL SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
          Hyperplasia                      |                                                       2                  |      1  2.0|
      Germinal Epithelium, Atrophy         | 4     4        4                 4     4  4        4           4        4|     13  3.8|

 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Fibrosis                             |                                                                         3|      2  2.5|

                                            __________________________________________________________________________|____________|
   Lymph Node                              |                         +                                                |   1        |

                                            __________________________________________________________________________|____________|
   Lymph Node, Bronchial                   | +  +  M  +  +  +  +  M  M  +  +  M  +  +  +  +  +  +  +  M  +  +  +  +  +|  40        |

                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Hyperplasia                          |                                                                   3      |      1  3.0|

                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |

                                            __________________________________________________________________________|____________|
   Lymph Node, Mediastinal                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |

                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Fibrosis                             | 3     3        2  2                          3                          3|     16  3.4|
      Hemorrhage                           |                         4                                                |      1  4.0|

                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |

 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Galactocele                          |                   2                                2  1     2            |      5  1.8|

                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |

 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |

 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hemorrhage                           |                                              2  3     4              4   |     10  3.2|
      Hydrocephalus                        |                3                                   3  3  3  3            |     10  2.7|
      Mineralization                       |                                        2                                 |      1  2.0|

 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Larynx                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Foreign Body                         |                                                                   X      |      3     |
      Glands, Inflammation                 | 2     2  1        1           2                                1  2      |     18  1.6|
      Squamous Epithelium, Hyperplasia     |       1                                                                  |      1  1.0|

                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Mineralization                       |                                                                          |      1  4.0|
      Alveolar Epithelium, Hyperplasia     |    4                                                                     |      5  2.2|

 __________________________________________________________________________________________________________________________________ 

  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
NTP Experiment-Test: 05184-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           GLUTARALDEHYDE                                      Date: 09/14/98  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 08:29:41  
                                                                                                                                    

 __________________________________________________________________________________________________________________________________ 
                                           | 6| 5| 7| 7| 7| 7| 7| 6| 6| 5| 7| 7| 6| 7| 6| 7| 5| 6| 6| 3| 6| 6| 5| 6| 6|            |
                             DAY ON TEST   | 1| 3| 2| 2| 1| 0| 2| 8| 5| 2| 2| 2| 5| 2| 8| 2| 2| 8| 6| 9| 0| 8| 8| 4| 3|            |
                                           | 2| 3| 1| 9| 1| 2| 9| 9| 4| 5| 9| 9| 2| 9| 6| 9| 4| 9| 1| 3| 9| 8| 1| 5| 2|      T (*) |

 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|      A     |
    500 PPB                                | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |

 __________________________________________________________________________________________________________________________________ 
 RESPIRATORY SYSTEM - cont                 |                                                                          |            |
                                           |                                                                          |            |
      Alveolus, Hemorrhage                 |                                                                          |      1  2.0|
      Alveolus, Infiltration Cellular,     |                                                                          |            |
           Histiocyte                      |                      1        1                                2         |     14  2.1|
      Alveolus, Metaplasia, Osseous        |                                                                          |      1  4.0|
      Alveolus, Mineralization             |                                                                         4|      1  4.0|
      Bronchiole, Hyperplasia              |                                                                          |      1  3.0|
      Bronchiole, Inflammation, Suppurative|                                           4                              |      1  4.0|
      Interstitium, Fibrosis               | 2     2              1                                         1        2|     17  1.8|

                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Foreign Body                         |                                                                          |      1     |
      Goblet Cell, Respiratory Epithelium, |                                                                          |            |
           Hyperplasia                     | 1                                2                                      2|      6  1.8|
      Olfactory Epithelium, Degeneration,  |                                                                          |            |
           Hyaline                         | 2              1  1                                      1               |      9  1.1|
      Olfactory Epithelium, Foreign Body   |                               X                                          |      1     |
      Olfactory Epithelium, Inflammation   |                               3                                          |      1  3.0|
      Respiratory Epithelium, Hyperplasia  | 2     2  2        1  2        1                       2        2        2|     17  1.9|
      Respiratory Epithelium, Inflammation | 3     2  3        2  3  2     2     1     3  2        3        4        4|     25  2.4|
      Respiratory Epithelium, Metaplasia,  |                                                                          |            |
           Squamous                        | 2        2           2                                1        2        2|     11  2.0|
      Squamous Epithelium, Hyperplasia     | 2     3  3  2     3  3  3  2  2  2  3     3  2     2  2        3        2|     39  2.2|
      Squamous Epithelium, Inflammation    | 3     3  4  3     3  4  4  2  3  3  3     3  3     2  3     1  4     1  4|     41  2.7|

                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |

 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Eye                                     |                                              +                           |   3        |
      Cataract                             |                                                                          |      2  1.5|
      Inflammation, Suppurative            |                                              4                           |      1  4.0|

                                            __________________________________________________________________________|____________|
   Zymbal's Gland                          |                                                                   +      |   1        |

 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cyst                                 |                                                                          |      1  3.0|
      Nephropathy, Chronic                 | 3  1  3  2  3  3  4  4  3  3  4  4  3  2  3  3  3  4  4  2  2  3  2  3  4|     48  3.0|

                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Transitional Epithelium, Hyperplasia |                                                                          |      1  2.0|

 __________________________________________________________________________________________________________________________________ 

  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
NTP Experiment-Test: 05184-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           GLUTARALDEHYDE                                      Date: 09/14/98  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 08:29:41  
                                                                                                                                    

 _____________________________________________________________________________________________________________________              
                                           | 2| 4| 7| 1| 1| 7| 1| 4| 6| 0| 7| 7| 6| 6| 6| 0| 1| 7| 7| 5| 6| 7| 5| 7| 6|             
                             DAY ON TEST   | 6| 6| 0| 0| 0| 1| 1| 9| 8| 2| 2| 2| 7| 2| 3| 9| 0| 2| 2| 6| 4| 2| 8| 1| 3|             
                                           | 2| 8| 8| 6| 5| 2| 1| 2| 9| 3| 9| 9| 3| 5| 8| 9| 0| 9| 9| 4| 6| 1| 9| 6| 8|             

 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|             
    750 PPB                                | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             

 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  A  +  A  A  +  +  +  +  A  +  +  +  +  +  +  +  A  +  +  +  +|             

                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  A  +  A  A  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +|             
      Diverticulum                         |                                                                   X      |             
      Parasite Metazoan                    |                               1  1                                       |             

                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  A  +  A  A  +  +  +  +  A  +  +  +  +  +  +  +  A  +  +  +  +|             
      Parasite Metazoan                    |                                  1                                       |             

                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  A  +  A  A  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +|             

                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  A  +  A  A  +  +  +  +  A  +  +  +  +  +  +  +  A  +  +  +  +|             
      Necrosis                             |                                                                          |             

                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  A  +  A  A  +  +  +  +  A  +  +  +  +  +  +  +  A  +  +  +  +|             

                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                                                         2|             
      Clear Cell Focus                     |                                                                         X|             
      Vacuolization Cytoplasmic            |                                                                          |             
      Bile Duct, Hyperplasia               |                                                                          |             
      Hepatocyte, Degeneration, Focal      |                                                                          |             

                                            __________________________________________________________________________|             
   Mesentery                               |                                                                          |             
      Fat, Necrosis                        |                                                                          |             

                                            __________________________________________________________________________|             
   Oral Mucosa                             |                                                                          |             

                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  A  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Acinus, Atrophy                      |                               2  3                                       |             

                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  A  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |                2                                                         |             
      Inflammation, Suppurative            |                4                    3                                    |             
      Ulcer                                |                                     4                                    |             
      Epithelium, Hyperplasia              |          1                                               2               |             

                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  A  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Erosion                              |                                                                          |             
      Epithelium, Mineralization           |                      4              3                                    |             

                                            __________________________________________________________________________|             
   Tongue                                  |                                                                          |             

                                            __________________________________________________________________________|             
   Tooth                                   | +        +  +     +                          +  +                        |             
      Degeneration                         | 3        3  3     3                          3  3                        |             
      Inflammation                         | 4                                                                        |             

 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Blood Vessel                            | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Mineralization                       |                      4              4                                    |             

                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Mineralization                       |                      4              4                                    |             
      Myocardium, Fibrosis                 |       2                       1  1                                       |             

 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             

 _____________________________________________________________________________________________________________________|             
NTP Experiment-Test: 05184-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           GLUTARALDEHYDE                                      Date: 09/14/98  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 08:29:41  
                                                                                                                                    

 _____________________________________________________________________________________________________________________              
                                           | 2| 4| 7| 1| 1| 7| 1| 4| 6| 0| 7| 7| 6| 6| 6| 0| 1| 7| 7| 5| 6| 7| 5| 7| 6|             
                             DAY ON TEST   | 6| 6| 0| 0| 0| 1| 1| 9| 8| 2| 2| 2| 7| 2| 3| 9| 0| 2| 2| 6| 4| 2| 8| 1| 3|             
                                           | 2| 8| 8| 6| 5| 2| 1| 2| 9| 3| 9| 9| 3| 5| 8| 9| 0| 9| 9| 4| 6| 1| 9| 6| 8|             

 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|             
    750 PPB                                | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             

 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |                                                                          |             
      Hyperplasia                          |                                                                          |             
      Vacuolization Cytoplasmic            |                1                                                         |             

                                            __________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                                    2                     |             

                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  A  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

                                            __________________________________________________________________________|             
   Parathyroid Gland                       | M  +  +  +  M  +  +  M  M  M  M  +  +  +  +  +  M  +  +  +  +  +  +  M  +|             
      Hyperplasia                          |                                     2                                    |             

                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                                                          |             
      Hemorrhage                           |                4     4                                               4   |             
      Pars Distalis, Hyperplasia           |                                                                          |             

                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      C-Cell, Hyperplasia                  |                1                 4                                       |             

 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             

 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Coagulating Gland                       |                   +                                                      |             

                                            __________________________________________________________________________|             
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

                                            __________________________________________________________________________|             
   Preputial Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Suppurative            |                                                                          |             

                                            __________________________________________________________________________|             
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation                         |                                                                      2   |             

                                            __________________________________________________________________________|             
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic                |                                                                          |             

                                            __________________________________________________________________________|             
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Bilateral, Interstitial Cell,        |                                                                          |             
          Hyperplasia                      |    4                    3                                                |             
      Germinal Epithelium, Atrophy         |       3                                                                  |             

 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrosis                             |                      3                                                   |             

                                            __________________________________________________________________________|             
   Lymph Node                              |                                                          +               |             

                                            __________________________________________________________________________|             
   Lymph Node, Bronchial                   | M  +  M  M  M  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

                                            __________________________________________________________________________|             
   Lymph Node, Mediastinal                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Accessory Spleen                     |                                                                          |             
      Fibrosis                             |       3        3              3                    1                     |             

 _____________________________________________________________________________________________________________________|             
NTP Experiment-Test: 05184-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           GLUTARALDEHYDE                                      Date: 09/14/98  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 08:29:41  
                                                                                                                                    

 _____________________________________________________________________________________________________________________              
                                           | 2| 4| 7| 1| 1| 7| 1| 4| 6| 0| 7| 7| 6| 6| 6| 0| 1| 7| 7| 5| 6| 7| 5| 7| 6|             
                             DAY ON TEST   | 6| 6| 0| 0| 0| 1| 1| 9| 8| 2| 2| 2| 7| 2| 3| 9| 0| 2| 2| 6| 4| 2| 8| 1| 3|             
                                           | 2| 8| 8| 6| 5| 2| 1| 2| 9| 3| 9| 9| 3| 5| 8| 9| 0| 9| 9| 4| 6| 1| 9| 6| 8|             

 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|             
    750 PPB                                | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             

 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperkeratosis                       |                                                                          |             
      Hyperplasia                          |                                                                          |             
      Ulcer                                |                                                                          |             

 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |                                                                          |             
      Hydrocephalus                        |                                           2                       3      |             

 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Larynx                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Foreign Body                         | X                                                                        |             
      Epiglottis, Inflammation, Suppurative|    1                                                                     |             
      Glands, Inflammation                 |    2  2  1     1        1        2  2     1     1     1     1  1     1  1|             
      Squamous Epithelium, Hyperplasia     |                                                                          |             

                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation                         |                                                                          |             
      Alveolar Epithelium, Hyperplasia     |    1                                            1                        |             
      Alveolus, Hemorrhage                 |                                                                          |             
      Alveolus, Infiltration Cellular,     |                                                                          |             
           Histiocyte                      |    2  1              1  2     1        1           1                     |             
      Alveolus, Inflammation, Suppurative  |                            3                                             |             
      Alveolus, Mineralization             |                      3              1                                    |             
      Bronchiole, Foreign Body             |                            X                                             |             
      Interstitium, Fibrosis               |    1  1              2  2              1                                 |             

                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Goblet Cell, Respiratory Epithelium, |                                                                          |             
           Hyperplasia                     |                1                 1                                      1|             
      Olfactory Epithelium, Atrophy        |                                                 2                        |             
      Olfactory Epithelium, Degeneration,  |                                                                          |             
           Hyaline                         |       2                 1     1  1        2                 1  1        1|             
      Respiratory Epithelium, Hyperplasia  | 2  3  3        1        2  2  3  1  2  1        2  3  2        2  1      |             
      Respiratory Epithelium, Inflammation | 4  4  3  3  4  4  4  4  4  3  4  2  4  3  3  3  3  3  4  3     4  1  4  2|             
      Respiratory Epithelium, Metaplasia,  |                                                                          |             
           Squamous                        | 3  3  3  1           3  2  2  2                 2  3  3  1     3  2  2  1|             
      Squamous Epithelium, Hyperplasia     | 4  3  3  3  3  4  4  4  4  2  3  3  3  3  3  4  2  4  4  2  2  4     3  3|             

 _____________________________________________________________________________________________________________________|             
NTP Experiment-Test: 05184-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           GLUTARALDEHYDE                                      Date: 09/14/98  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 08:29:41  
                                                                                                                                    

 _____________________________________________________________________________________________________________________              
                                           | 2| 4| 7| 1| 1| 7| 1| 4| 6| 0| 7| 7| 6| 6| 6| 0| 1| 7| 7| 5| 6| 7| 5| 7| 6|             
                             DAY ON TEST   | 6| 6| 0| 0| 0| 1| 1| 9| 8| 2| 2| 2| 7| 2| 3| 9| 0| 2| 2| 6| 4| 2| 8| 1| 3|             
                                           | 2| 8| 8| 6| 5| 2| 1| 2| 9| 3| 9| 9| 3| 5| 8| 9| 0| 9| 9| 4| 6| 1| 9| 6| 8|             

 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|             
    750 PPB                                | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             

 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
      Squamous Epithelium, Inflammation    | 4  4  4  3  4  4  4  4  4  4  4  3  4  4  4  4  3  3  4  3  2  4  1  4  4|             

                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Ear                                     |                   +                                                      |             

 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                                    1                     |             
      Nephropathy, Chronic                 |    2  4        4     4        3  4  4  3  3        4  3  3  3  2  3  2  4|             

                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  A  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

 _____________________________________________________________________________________________________________________|             
NTP Experiment-Test: 05184-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           GLUTARALDEHYDE                                      Date: 09/14/98  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 08:29:41  
                                                                                                                                    

 __________________________________________________________________________________________________________________________________ 
                                           | 5| 6| 5| 3| 6| 6| 6| 4| 6| 5| 7| 5| 7| 4| 1| 6| 5| 5| 7| 7| 1| 1| 7| 6| 7|            |
                             DAY ON TEST   | 0| 0| 8| 9| 8| 0| 5| 7| 3| 9| 2| 8| 0| 4| 0| 6| 0| 6| 2| 0| 0| 0| 2| 2| 1|            |
                                           | 8| 3| 9| 3| 3| 8| 2| 4| 4| 3| 9| 6| 8| 9| 6| 6| 2| 1| 0| 8| 7| 6| 9| 0| 8|      T (*) |

 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|      A     |
    750 PPB                                | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |

 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |

                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  45        |

                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  46        |
      Diverticulum                         |                                                                          |      1     |
      Parasite Metazoan                    |                               1                                          |      3  1.0|

                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  45        |
      Parasite Metazoan                    |             1                                                            |      2  1.0|

                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  46        |

                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  44        |
      Necrosis                             |          4                                                               |      1  4.0|

                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  44        |

                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Angiectasis                          |                                                       1  2               |      3  1.7|
      Clear Cell Focus                     |                                                                          |      1     |
      Vacuolization Cytoplasmic            |                                                    3                     |      1  3.0|
      Bile Duct, Hyperplasia               |                                     1           2                        |      2  1.5|
      Hepatocyte, Degeneration, Focal      |                                     2                                    |      1  2.0|

                                            __________________________________________________________________________|____________|
   Mesentery                               |                   +  +           +     +     +  +                    +   |   7        |
      Fat, Necrosis                        |                   2  1           3     4        4                    3   |      6  2.8|

                                            __________________________________________________________________________|____________|
   Oral Mucosa                             |                               +                                          |   1        |

                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Acinus, Atrophy                      |                                  2                 2     2               |      5  2.2|

                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |

                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Hemorrhage                           |                                                                          |      1  2.0|
      Inflammation, Suppurative            |                                  4        3                 2            |      5  3.2|
      Ulcer                                |                                           4                              |      2  4.0|
      Epithelium, Hyperplasia              |                                  3                          2            |      4  2.0|

                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Erosion                              |                2                       3                                 |      2  2.5|
      Epithelium, Mineralization           |             3                       4                                    |      4  3.5|

                                            __________________________________________________________________________|____________|
   Tongue                                  |                                                       +                  |   1        |

                                            __________________________________________________________________________|____________|
   Tooth                                   |                                           +                 +            |   8        |
      Degeneration                         |                                           4                 4            |      8  3.3|
      Inflammation                         |                                                                          |      1  4.0|

 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Blood Vessel                            | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Mineralization                       |                                     4              4                     |      4  4.0|

 __________________________________________________________________________________________________________________________________ 

  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
NTP Experiment-Test: 05184-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           GLUTARALDEHYDE                                      Date: 09/14/98  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 08:29:41  
                                                                                                                                    

 __________________________________________________________________________________________________________________________________ 
                                           | 5| 6| 5| 3| 6| 6| 6| 4| 6| 5| 7| 5| 7| 4| 1| 6| 5| 5| 7| 7| 1| 1| 7| 6| 7|            |
                             DAY ON TEST   | 0| 0| 8| 9| 8| 0| 5| 7| 3| 9| 2| 8| 0| 4| 0| 6| 0| 6| 2| 0| 0| 0| 2| 2| 1|            |
                                           | 8| 3| 9| 3| 3| 8| 2| 4| 4| 3| 9| 6| 8| 9| 6| 6| 2| 1| 0| 8| 7| 6| 9| 0| 8|      T (*) |

 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|      A     |
    750 PPB                                | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |

 __________________________________________________________________________________________________________________________________ 
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Mineralization                       |                                     3              2                     |      4  3.3|
      Myocardium, Fibrosis                 |             2                       3        3     3                     |      7  2.1|

 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Hemorrhage                           |                                     3                                    |      1  3.0|
      Hyperplasia                          |                                                                   1      |      1  1.0|
      Vacuolization Cytoplasmic            |                         1                                                |      2  1.0|

                                            __________________________________________________________________________|____________|
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Hyperplasia                          |                                                          2               |      2  2.0|

                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |

                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +|  41        |
      Hyperplasia                          |             2                                      3                     |      3  2.3|

                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cyst                                 |                                     2                                    |      1  2.0|
      Hemorrhage                           |                                                                          |      3  4.0|
      Pars Distalis, Hyperplasia           |                                                                         2|      1  2.0|

                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      C-Cell, Hyperplasia                  |                            1           1                 1               |      5  1.6|

 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |

 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Coagulating Gland                       |                                                                          |   1        |

                                            __________________________________________________________________________|____________|
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |

                                            __________________________________________________________________________|____________|
   Preputial Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inflammation, Suppurative            |                                     4                                    |      1  4.0|

                                            __________________________________________________________________________|____________|
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inflammation                         |                   2                                         4            |      3  2.7|

                                            __________________________________________________________________________|____________|
   Seminal Vesicle                         | +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Inflammation, Chronic                |                                                          2               |      1  2.0|

                                            __________________________________________________________________________|____________|
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Bilateral, Interstitial Cell,        |                                                                          |            |
          Hyperplasia                      |          2                             2                                 |      4  2.8|
      Germinal Epithelium, Atrophy         |                      4     4        3           3        3               |      6  3.3|

 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |

 __________________________________________________________________________________________________________________________________ 

  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
NTP Experiment-Test: 05184-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           GLUTARALDEHYDE                                      Date: 09/14/98  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 08:29:41  
                                                                                                                                    

 __________________________________________________________________________________________________________________________________ 
                                           | 5| 6| 5| 3| 6| 6| 6| 4| 6| 5| 7| 5| 7| 4| 1| 6| 5| 5| 7| 7| 1| 1| 7| 6| 7|            |
                             DAY ON TEST   | 0| 0| 8| 9| 8| 0| 5| 7| 3| 9| 2| 8| 0| 4| 0| 6| 0| 6| 2| 0| 0| 0| 2| 2| 1|            |
                                           | 8| 3| 9| 3| 3| 8| 2| 4| 4| 3| 9| 6| 8| 9| 6| 6| 2| 1| 0| 8| 7| 6| 9| 0| 8|      T (*) |

 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|      A     |
    750 PPB                                | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |

 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Fibrosis                             |                                     2              4                     |      3  3.0|

                                            __________________________________________________________________________|____________|
   Lymph Node                              |                +                                                     +  +|   4        |

                                            __________________________________________________________________________|____________|
   Lymph Node, Bronchial                   | M  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  M  +  +  +  +  +  +  +  +|  42        |

                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |

                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |

                                            __________________________________________________________________________|____________|
   Lymph Node, Mediastinal                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |

                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Accessory Spleen                     | X                                                                        |      1     |
      Fibrosis                             |             3                                      3     2        3     3|      9  2.7|

                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |

 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |

                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperkeratosis                       |             4                                                            |      1  4.0|
      Hyperplasia                          |             3                                                            |      1  3.0|
      Ulcer                                |             4                                                            |      1  4.0|

 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |

 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hemorrhage                           |                4                                                         |      1  4.0|
      Hydrocephalus                        |    2                    3        3                                       |      5  2.6|

 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Larynx                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Foreign Body                         |                         X                                                |      2     |
      Epiglottis, Inflammation, Suppurative|                                                                          |      1  1.0|
      Glands, Inflammation                 | 1     2           1     2           3  1  1  1  1        1           1  1|     26  1.3|
      Squamous Epithelium, Hyperplasia     |       2                                                                  |      1  2.0|

                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inflammation                         |                                                                      4   |      1  4.0|
      Alveolar Epithelium, Hyperplasia     |                3                                                     4   |      4  2.3|
      Alveolus, Hemorrhage                 |                               2                                          |      1  2.0|
      Alveolus, Infiltration Cellular,     |                                                                          |            |
           Histiocyte                      |                3                    1              2                 3   |     11  1.6|

 __________________________________________________________________________________________________________________________________ 

  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
NTP Experiment-Test: 05184-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           GLUTARALDEHYDE                                      Date: 09/14/98  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 08:29:41  
                                                                                                                                    

 __________________________________________________________________________________________________________________________________ 
                                           | 5| 6| 5| 3| 6| 6| 6| 4| 6| 5| 7| 5| 7| 4| 1| 6| 5| 5| 7| 7| 1| 1| 7| 6| 7|            |
                             DAY ON TEST   | 0| 0| 8| 9| 8| 0| 5| 7| 3| 9| 2| 8| 0| 4| 0| 6| 0| 6| 2| 0| 0| 0| 2| 2| 1|            |
                                           | 8| 3| 9| 3| 3| 8| 2| 4| 4| 3| 9| 6| 8| 9| 6| 6| 2| 1| 0| 8| 7| 6| 9| 0| 8|      T (*) |

 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|      A     |
    750 PPB                                | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |

 __________________________________________________________________________________________________________________________________ 
 RESPIRATORY SYSTEM - cont                 |                                                                          |            |
                                           |                                                                          |            |
      Alveolus, Inflammation, Suppurative  |                                                       2                  |      2  2.5|
      Alveolus, Mineralization             |                                     3              3                     |      4  2.5|
      Bronchiole, Foreign Body             |                                                                          |      1     |
      Interstitium, Fibrosis               |                                     1              2                     |      7  1.4|

                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Goblet Cell, Respiratory Epithelium, |                                                                          |            |
           Hyperplasia                     |       2  1           1                                                   |      6  1.2|
      Olfactory Epithelium, Atrophy        |                                           3                 2  2         |      4  2.3|
      Olfactory Epithelium, Degeneration,  |                                                                          |            |
           Hyaline                         |    1           1     1     1     1                 1                     |     14  1.1|
      Respiratory Epithelium, Hyperplasia  | 2           2  2  3  2  2  1  2  2  2  2  2  2  1  1  1  2     2  2     1|     35  1.9|
      Respiratory Epithelium, Inflammation | 3           3  4  4  2  3  3     4  3  3     3  3  3  2  3     3  3  3  3|     43  3.2|
      Respiratory Epithelium, Metaplasia,  |                                                                          |            |
           Squamous                        | 1           2  2  3  2        3                                   2     1|     24  2.2|
      Squamous Epithelium, Hyperplasia     | 4  2  2     3  3  3  3  2  3  2  3  4  3  3  3  2  2  2  3  2  2  3  2  2|     48  2.9|
      Squamous Epithelium, Inflammation    | 4  2  2     4  4  4  3  4  4  4  4  4  4  4  4  4  3  3  4  3  4  4  3  4|     49  3.6|

                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |

 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Ear                                     |                                                                          |   1        |

 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cyst                                 |                                                                   2      |      2  1.5|
      Nephropathy, Chronic                 | 1  4  2  1  4  2  2  1  2  1  4  4  4        2  3  4  4  3        4  1  2|     38  2.9|

                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |

 __________________________________________________________________________________________________________________________________ 

  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
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                             ----------              END OF REPORT             ----------                                           
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