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TDMS Study 05184-05 Pathology Tables

NTP                                    STATISTICAL ANALYSIS OF NON-NEOPLASTIC LESIONS                          REPORT: PEIRPT10     
LAB: Battelle Northwest                                      GLUTARALDEHYDE                                    DATE: 09/14/98       
EXPERIMENT: 05184 TEST: 05                                                                                     TIME: 08:31:56       
TEST TYPE:  CHRONIC                             CAGES FROM 0000 TO LAST CAGE                                   PAGE:       1        
CONT: NO1-ES-25335                              ROUTE: RESPIRATORY EXPOSURE WHOLE BODY                         NTP C#: 55425C       
PATHOLOGIST: RENNE, ROGER                                                                                      CAS: 111-30-8        
------------------------------------------------------------------------------------------------------------------------------------
                                                                                                                                    
                                                           2 YEAR CHRONIC                                                           
                                                                                                                                    

               REASONS FOR REMOVAL:    ALL                                                                                          
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
               REMOVAL DATE RANGE:     ALL                                                                                          
                                                                                                                                    
               TREATMENT GROUPS:       INCLUDE ALL                                                                                  
NTP                                    STATISTICAL ANALYSIS OF NON-NEOPLASTIC LESIONS                          REPORT: PEIRPT10   
LAB: Battelle Northwest                                      GLUTARALDEHYDE                                    DATE: 09/14/98     
EXPERIMENT: 05184 TEST: 05                                                                                     TIME: 08:31:56     
TEST TYPE:  CHRONIC                             CAGES FROM 0000 TO LAST CAGE                                                      
CONT: NO1-ES-25335                              ROUTE: RESPIRATORY EXPOSURE WHOLE BODY                         NTP C#: 55425C     
PATHOLOGIST: RENNE, ROGER                                                                                      CAS: 111-30-8      



SUMMARY OF STATISTICALLY SIGNIFICANT (P<=.05) RESULTS
IN THE ANALYSIS OF                  GLUTARALDEHYDE
===============================================================

Male Rats
------------
Organ                                 Morphology
-----                                 ----------
Adrenal Cortex                         Vacuolization Cytoplasmic
Adrenal Medulla                        Hyperplasia
Blood Vessel                           Mineralization
Brain                                  Hemorrhage
Heart: Atrium                          Thrombosis
Intestine Large, Rectum                Parasite Metazoan
Kidney                                 Mineralization
                                       Nephropathy Chronic
Larynx: Glands                         Inflammation
Liver                                  Vacuolization Cytoplasmic
Lung: Alveolar Epithelium              Hyperplasia
Lung: Alveolus                         Infiltration Cellular Histiocyte
Lung: Interstitium                     Fibrosis
Nose: Goblet Cell, Respiratory Epithelium
                                       Hyperplasia
Nose: Olfactory Epithelium             Atrophy
                                       Degeneration Hyaline
Nose: Respiratory Epithelium           Hyperplasia
                                       Inflammation
                                       Metaplasia
Nose: Squamous Epithelium              Hyperplasia
                                       Inflammation
Pancreas: Acinus                       Atrophy
Parathyroid Gland                      Hyperplasia
Pituitary Gland                        Hemorrhage
Pituitary Gland: Pars Distalis         Hyperplasia
Prostate                               Inflammation
Seminal Vesicle                        Inflammation
Stomach, Forestomach                   Mineralization
Stomach, Forestomach: Epithelium       Hyperplasia
===============================================================
Female Rats
------------
Organ                                  Morphology
-----                                  ----------
Adrenal Cortex                         Vacuolization Cytoplasmic
Brain                                  Hydrocephalus
Kidney                                 Nephropathy Chronic
Larynx: Epiglottis                     Inflammation
Larynx: Glands                         Inflammation
Larynx: Squamous Epithelium            Hyperplasia
Liver                                  Necrosis
                                       Vacuolization Cytoplasmic
Lung: Alveolus                         Emphysema
                                       Infiltration Cellular Histiocyte
Lung: Interstitium                     Fibrosis
Nose                                   Concretion
                                       Foreign Body
NTP                                    STATISTICAL ANALYSIS OF NON-NEOPLASTIC LESIONS                          REPORT: PEIRPT10   
LAB: Battelle Northwest                                      GLUTARALDEHYDE                                    DATE: 09/14/98     
EXPERIMENT: 05184 TEST: 05                                                                                     TIME: 08:31:56     
TEST TYPE:  CHRONIC                             CAGES FROM 0000 TO LAST CAGE                                                      
CONT: NO1-ES-25335                              ROUTE: RESPIRATORY EXPOSURE WHOLE BODY                         NTP C#: 55425C     
PATHOLOGIST: RENNE, ROGER                                                                                      CAS: 111-30-8      

Nose: Goblet Cell, Respiratory Epithelium
                                       Hyperplasia
Nose: Olfactory Epithelium             Atrophy
                                       Degeneration Hyaline
Nose: Respiratory Epithelium           Hyperplasia
                                       Inflammation
                                       Metaplasia
Nose: Squamous Epithelium              Hyperplasia
                                       Inflammation
Pituitary Gland: Pars Distalis         Hyperplasia
===============================================================
       Date:  09/14/98                           EXPERIMENT: 05184 TEST: 05                                            Page 1
                     Statistical Analysis of Non-neoplastic Lesions in        Rats(FISCHER 344)  -                   GLUTARALDEHYDE
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      250 PPB      500 PPB      750 PPB     |CONTROL      250 PPB      500 PPB      750 PPB      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Adrenal Cortex                                                                                                                   |
|     Vacuolization Cytoplasmic                                                                                                   |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     9/50 (18%)   6/50 (12%)   8/50 (16%)   2/49 (4%)   |7/50 (14%)   6/50 (12%)   11/50 (22%)  9/49 (18%)   |
|POLY-3 ADJUSTED (b)|     23.7%        15.3%        21.5%        7.2%        |16.5%        14.2%        29.1%        26.9%        |
|TERMINAL (d)       |     2/12 (17%)   3/14 (21%)   2/9 (22%)    0/6 (0%)    |5/26 (19%)   5/31 (16%)   3/15 (20%)   5/14 (36%)   |
|FIRST INCIDENCE    |     117          577          581          634         |589          675          614          516          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.169N     P=0.194N     P=0.553N     P=0.096N    |P=0.014 *    P=0.390N     P=0.052      P=0.082      |
|POLY 3             |     P=0.135N     P=0.255N     P=0.521N     P=0.077N    |P=0.070      P=0.500N     P=0.138      P=0.209      |
|POLY 1.5           |     P=0.116N     P=0.269N     P=0.512N     P=0.067N    |P=0.091      P=0.507N     P=0.168      P=0.238      |
|POLY 6             |     P=0.155N     P=0.242N     P=0.539N     P=0.087N    |P=0.055      P=0.484N     P=0.112      P=0.187      |
|LOGISTIC REGRESSION|     P=0.073N     P=0.304N     P=0.503N     P=0.038N*   |P=0.063      P=0.475N     P=0.125      P=0.205      |
|COCH-ARM / FISHERS |     P=0.046N*    P=0.288N     P=0.500N     P=0.028N*   |P=0.185      P=0.500N     P=0.218      P=0.376      |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      250 PPB      500 PPB      750 PPB     |CONTROL      250 PPB      500 PPB      750 PPB      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Adrenal Medulla                                                                                                                  |
|     Hyperplasia                                                                                                                 |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     13/50 (26%)  9/50 (18%)   6/50 (12%)   2/49 (4%)   |2/50 (4%)    1/50 (2%)    2/50 (4%)    1/49 (2%)    |
|POLY-3 ADJUSTED (b)|     34.4%        22.5%        16.0%        7.3%        |4.8%         2.4%         5.5%         3.2%         |
|TERMINAL (d)       |     3/12 (25%)   4/14 (29%)   0/9 (0%)     1/6 (17%)   |0/26 (0%)    0/31 (0%)    1/15 (7%)    0/14 (0%)    |
|FIRST INCIDENCE    |     555          617          365          708         |638          724          533          716          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.012N*    P=0.133N     P=0.111N     P=0.025N*   |P=0.515      P=0.455N     P=0.560      P=0.650N     |
|POLY 3             |     P=0.004N**   P=0.175N     P=0.051N     P=0.010N*   |P=0.545N     P=0.500N     P=0.641      P=0.596N     |
|POLY 1.5           |     P=0.003N**   P=0.194N     P=0.052N     P=0.008N**  |P=0.516N     P=0.503N     P=0.664      P=0.575N     |
|POLY 6             |     P=0.005N**   P=0.158N     P=0.054N     P=0.014N*   |P=0.576N     P=0.492N     P=0.609      P=0.617N     |
|LOGISTIC REGRESSION|     P=0.003N**   P=0.158N     P=0.060N     P=0.009N**  |P=0.500N     P=0.499N     P=0.697      P=0.594N     |
|COCH-ARM / FISHERS |     P<0.001N**   P=0.235N     P=0.062N     P=0.002N**  |P=0.433N     P=0.500N     P=0.691N     P=0.508N     |
|=================================================================================================================================|
       Date:  09/14/98                           EXPERIMENT: 05184 TEST: 05                                            Page 2
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                   GLUTARALDEHYDE
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      250 PPB      500 PPB      750 PPB     |CONTROL      250 PPB      500 PPB      750 PPB      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Blood Vessel                                                                                                                     |
|     Inflammation                                                                                                                |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     1/45 (2%)    2/50 (4%)    0/50 (0%)    0/50 (0%)   |1/50 (2%)    1/50 (2%)    0/50 (0%)    1/49 (2%)    |
|POLY-3 ADJUSTED (b)|     3.0%         5.1%         0.0%         0.0%        |2.4%         2.3%         0.0%         3.1%         |
|TERMINAL (d)       |     1/12 (8%)    0/14 (0%)    0/9 (0%)     0/6 (0%)    |0/26 (0%)    0/31 (0%)    0/15 (0%)    0/14 (0%)    |
|FIRST INCIDENCE    |     729 (T)      652          ---          ---         |698          561          ---          253          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.212N     P=0.556      P=0.557N     P=0.638N    |P=0.572N     P=0.748N     P=0.578N     P=0.710      |
|POLY 3             |     P=0.178N     P=0.562      P=0.484N     P=0.535N    |P=0.566N     P=0.757N     P=0.531N     P=0.702      |
|POLY 1.5           |     P=0.170N     P=0.550      P=0.482N     P=0.526N    |P=0.545N     P=0.760N     P=0.518N     P=0.715      |
|POLY 6             |     P=0.187N     P=0.579      P=0.488N     P=0.542N    |P=0.591N     P=0.750N     P=0.549N     P=0.689      |
|LOGISTIC REGRESSION|     P=0.169N     P=0.564      (e)          (e)         |P=0.349N     P=0.758N     P=0.541N     P=0.667N     |
|COCH-ARM / FISHERS |     P=0.133N     P=0.540      P=0.474N     P=0.474N    |P=0.505N     P=0.753N     P=0.500N     P=0.747      |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      250 PPB      500 PPB      750 PPB     |CONTROL      250 PPB      500 PPB      750 PPB      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Blood Vessel                                                                                                                     |
|     Mineralization                                                                                                              |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     7/45 (16%)   3/50 (6%)    1/50 (2%)    4/50 (8%)   |0/50 (0%)    0/50 (0%)    1/50 (2%)    0/49 (0%)    |
|POLY-3 ADJUSTED (b)|     21.1%        7.6%         2.8%         13.8%       |0.0%         0.0%         2.8%         0.0%         |
|TERMINAL (d)       |     3/12 (25%)   0/14 (0%)    0/9 (0%)     0/6 (0%)    |0/26 (0%)    0/31 (0%)    0/15 (0%)    0/14 (0%)    |
|FIRST INCIDENCE    |     689          579          632          492         |---          ---          680          ---          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.252N     P=0.105N     P=0.060N     P=0.496N    |P=0.423      (e)          P=0.407      (e)          |
|POLY 3             |     P=0.114N     P=0.089N     P=0.019N*    P=0.335N    |P=0.448      (e)          P=0.470      (e)          |
|POLY 1.5           |     P=0.108N     P=0.102N     P=0.020N*    P=0.323N    |P=0.456      (e)          P=0.483      (e)          |
|POLY 6             |     P=0.121N     P=0.073N     P=0.019N*    P=0.337N    |P=0.444      (e)          P=0.455      (e)          |
|LOGISTIC REGRESSION|     P=0.147N     P=0.087N     P=0.026N*    P=0.374N    |P=0.467      (e)          P=0.479      (e)          |
|COCH-ARM / FISHERS |     P=0.088N     P=0.119N     P=0.020N*    P=0.204N    |P=0.497      (e)          P=0.500      (e)          |
|=================================================================================================================================|
       Date:  09/14/98                           EXPERIMENT: 05184 TEST: 05                                            Page 3
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                   GLUTARALDEHYDE
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      250 PPB      500 PPB      750 PPB     |CONTROL      250 PPB      500 PPB      750 PPB      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Bone Marrow                                                                                                                      |
|     Fibrosis                                                                                                                    |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     7/50 (14%)   5/50 (10%)   2/50 (4%)    3/50 (6%)   |0/50 (0%)    0/50 (0%)    2/50 (4%)    0/50 (0%)    |
|POLY-3 ADJUSTED (b)|     19.4%        12.3%        5.6%         10.4%       |0.0%         0.0%         5.5%         0.0%         |
|TERMINAL (d)       |     2/12 (17%)   0/14 (0%)    0/9 (0%)     0/6 (0%)    |0/26 (0%)    0/31 (0%)    1/15 (7%)    0/14 (0%)    |
|FIRST INCIDENCE    |     555          356          632          492         |---          ---          558          ---          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.154N     P=0.291N     P=0.135N     P=0.338N    |P=0.271      (e)          P=0.167      (e)          |
|POLY 3             |     P=0.089N     P=0.292N     P=0.074N     P=0.256N    |P=0.289      (e)          P=0.207      (e)          |
|POLY 1.5           |     P=0.084N     P=0.324N     P=0.075N     P=0.246N    |P=0.306      (e)          P=0.220      (e)          |
|POLY 6             |     P=0.096N     P=0.254N     P=0.076N     P=0.261N    |P=0.277      (e)          P=0.192      (e)          |
|LOGISTIC REGRESSION|     P=0.073N     P=0.373N     P=0.077N     P=0.256N    |P=0.366      (e)          P=0.242      (e)          |
|COCH-ARM / FISHERS |     P=0.056N     P=0.380N     P=0.080N     P=0.159N    |P=0.375      (e)          P=0.247      (e)          |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      250 PPB      500 PPB      750 PPB     |CONTROL      250 PPB      500 PPB      750 PPB      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Brain                                                                                                                            |
|     Hemorrhage                                                                                                                  |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     3/50 (6%)    4/50 (8%)    10/50 (20%)  1/50 (2%)   |3/49 (6%)    1/50 (2%)    7/50 (14%)   3/50 (6%)    |
|POLY-3 ADJUSTED (b)|     8.1%         10.1%        25.9%        3.6%        |7.2%         2.4%         17.4%        9.2%         |
|TERMINAL (d)       |     0/12 (0%)    0/14 (0%)    1/9 (11%)    0/6 (0%)    |2/26 (8%)    0/31 (0%)    0/15 (0%)    0/14 (0%)    |
|FIRST INCIDENCE    |     452          607          524          608         |566          615          355          641          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.367      P=0.590      P=0.052      P=0.400N    |P=0.133      P=0.279N     P=0.101      P=0.460      |
|POLY 3             |     P=0.264      P=0.541      P=0.037 *    P=0.410N    |P=0.150      P=0.296N     P=0.142      P=0.549      |
|POLY 1.5           |     P=0.309      P=0.526      P=0.037 *    P=0.391N    |P=0.176      P=0.300N     P=0.155      P=0.578      |
|POLY 6             |     P=0.223      P=0.564      P=0.039 *    P=0.427N    |P=0.129      P=0.287N     P=0.125      P=0.526      |
|LOGISTIC REGRESSION|     P=0.529      P=0.416      P=0.032 *    P=0.250N    |P=0.423      P=0.296N     P=0.282      P=0.601      |
|COCH-ARM / FISHERS |     P=0.544      P=0.500      P=0.036 *    P=0.309N    |P=0.276      P=0.301N     P=0.167      P=0.651N     |
|=================================================================================================================================|
       Date:  09/14/98                           EXPERIMENT: 05184 TEST: 05                                            Page 4
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                   GLUTARALDEHYDE
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      250 PPB      500 PPB      750 PPB     |CONTROL      250 PPB      500 PPB      750 PPB      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Brain                                                                                                                            |
|     Hydrocephalus                                                                                                               |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     5/50 (10%)   7/50 (14%)   10/50 (20%)  5/50 (10%)  |10/49 (20%)  10/50 (20%)  7/50 (14%)   2/50 (4%)    |
|POLY-3 ADJUSTED (b)|     13.2%        17.5%        25.3%        16.9%       |23.5%        22.9%        18.3%        6.3%         |
|TERMINAL (d)       |     0/12 (0%)    1/14 (7%)    0/9 (0%)     0/6 (0%)    |3/26 (12%)   6/31 (19%)   0/15 (0%)    1/14 (7%)    |
|FIRST INCIDENCE    |     392          615          393          586         |542          561          508          721          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.233      P=0.502      P=0.150      P=0.485     |P=0.123N     P=0.487N     P=0.588N     P=0.107N     |
|POLY 3             |     P=0.228      P=0.417      P=0.143      P=0.471     |P=0.047N*    P=0.575N     P=0.384N     P=0.046N*    |
|POLY 1.5           |     P=0.249      P=0.403      P=0.140      P=0.491     |P=0.030N*    P=0.585N     P=0.339N     P=0.033N*    |
|POLY 6             |     P=0.218      P=0.439      P=0.148      P=0.466     |P=0.076N     P=0.556N     P=0.441N     P=0.065N     |
|LOGISTIC REGRESSION|     P=0.432      P=0.334      P=0.098      P=0.634N    |P=0.018N*    P=0.581N     P=0.287N     P=0.037N*    |
|COCH-ARM / FISHERS |     P=0.427      P=0.380      P=0.131      P=0.630N    |P=0.009N**   P=0.579N     P=0.282N     P=0.013N*    |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      250 PPB      500 PPB      750 PPB     |CONTROL      250 PPB      500 PPB      750 PPB      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Clitoral Gland                                                                                                                   |
|     Hyperplasia                                                                                                                 |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |                                                        |4/49 (8%)    7/50 (14%)   0/50 (0%)    2/50 (4%)    |
|POLY-3 ADJUSTED (b)|                                                        |9.6%         16.5%        0.0%         6.3%         |
|TERMINAL (d)       |                                                        |2/26 (8%)    5/31 (16%)   0/15 (0%)    1/14 (7%)    |
|FIRST INCIDENCE    |                                                        |550          674          ---          721          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |                                                        |P=0.240N     P=0.335      P=0.125N     P=0.585N     |
|POLY 3             |                                                        |P=0.126N     P=0.269      P=0.082N     P=0.466N     |
|POLY 1.5           |                                                        |P=0.097N     P=0.266      P=0.071N     P=0.429N     |
|POLY 6             |                                                        |P=0.169N     P=0.280      P=0.100N     P=0.504N     |
|LOGISTIC REGRESSION|                                                        |P=0.125N     P=0.273      P=0.061N     P=0.438N     |
|COCH-ARM / FISHERS |                                                        |P=0.058N     P=0.274      P=0.056N     P=0.329N     |
|=================================================================================================================================|
       Date:  09/14/98                           EXPERIMENT: 05184 TEST: 05                                            Page 5
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                   GLUTARALDEHYDE
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      250 PPB      500 PPB      750 PPB     |CONTROL      250 PPB      500 PPB      750 PPB      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Eye                                                                                                                              |
|     Cataract                                                                                                                    |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     1/1 (100%)   3/3 (100%)   2/3 (67%)    0/0 (0%)    |1/2 (50%)    1/2 (50%)    3/3 (100%)   0/0 (0%)     |
|POLY-3 ADJUSTED (b)|     100.0%       100.0%       66.7%        0.0%        |65.6%        50.0%        100.0%       0.0%         |
|TERMINAL (d)       |     0/0 (0%)     1/1 (100%)   0/1 (0%)     0/0 (0%)    |1/1 (100%)   0/1 (0%)     1/1 (100%)   0/0 (0%)     |
|FIRST INCIDENCE    |     694          694          481          ---         |730 (T)      720          357          ---          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.407N     (e)          P=0.461      (e)         |P=0.357      P=0.738N     P=0.175      P=1.000      |
|POLY 3             |     (e)          (e)          P=0.691N     (e)         |(e)          P=0.721N     P=0.719      (e)          |
|POLY 1.5           |     (e)          (e)          P=0.691N     (e)         |(e)          P=0.741N     P=0.546      (e)          |
|POLY 6             |     (e)          (e)          P=0.691N     (e)         |(e)          P=0.683N     P=0.981      (e)          |
|LOGISTIC REGRESSION|     (e)          (e)          (e)          (e)         |P=0.222      P=0.703N     P=0.381      (e)          |
|COCH-ARM / FISHERS |     P=0.370N     (e)          P=0.750N     (e)         |P=0.215      P=0.833N     P=0.400      P=1.000      |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      250 PPB      500 PPB      750 PPB     |CONTROL      250 PPB      500 PPB      750 PPB      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Heart                                                                                                                            |
|     Mineralization                                                                                                              |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     6/50 (12%)   2/50 (4%)    1/50 (2%)    4/50 (8%)   |0/50 (0%)    0/50 (0%)    0/50 (0%)    0/50 (0%)    |
|POLY-3 ADJUSTED (b)|     16.9%        5.1%         2.8%         13.8%       |0.0%         0.0%         0.0%         0.0%         |
|TERMINAL (d)       |     2/12 (17%)   0/14 (0%)    0/9 (0%)     0/6 (0%)    |0/26 (0%)    0/31 (0%)    0/15 (0%)    0/14 (0%)    |
|FIRST INCIDENCE    |     689          579          632          492         |---          ---          ---          ---          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.385N     P=0.096N     P=0.097N     P=0.590N    |(e)          (e)          (e)          (e)          |
|POLY 3             |     P=0.259N     P=0.097N     P=0.050N     P=0.498N    |(e)          (e)          (e)          (e)          |
|POLY 1.5           |     P=0.251N     P=0.110N     P=0.052N     P=0.490N    |(e)          (e)          (e)          (e)          |
|POLY 6             |     P=0.270N     P=0.081N     P=0.049N*    P=0.496N    |(e)          (e)          (e)          (e)          |
|LOGISTIC REGRESSION|     P=0.295N     P=0.093N     P=0.057N     P=0.528N    |(e)          (e)          (e)          (e)          |
|COCH-ARM / FISHERS |     P=0.221N     P=0.134N     P=0.056N     P=0.370N    |(e)          (e)          (e)          (e)          |
|=================================================================================================================================|
       Date:  09/14/98                           EXPERIMENT: 05184 TEST: 05                                            Page 6
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                   GLUTARALDEHYDE
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      250 PPB      500 PPB      750 PPB     |CONTROL      250 PPB      500 PPB      750 PPB      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Heart: Atrium                                                                                                                    |
|     Thrombosis                                                                                                                  |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     3/50 (6%)    2/50 (4%)    1/50 (2%)    0/50 (0%)   |1/50 (2%)    1/50 (2%)    0/50 (0%)    0/50 (0%)    |
|POLY-3 ADJUSTED (b)|     8.4%         5.0%         2.7%         0.0%        |2.4%         2.4%         0.0%         0.0%         |
|TERMINAL (d)       |     0/12 (0%)    0/14 (0%)    0/9 (0%)     0/6 (0%)    |0/26 (0%)    0/31 (0%)    0/15 (0%)    0/14 (0%)    |
|FIRST INCIDENCE    |     612          495          365          ---         |651          724          ---          ---          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.071N     P=0.439N     P=0.316N     P=0.182N    |P=0.245N     P=0.737N     P=0.559N     P=0.566N     |
|POLY 3             |     P=0.077N     P=0.450N     P=0.297N     P=0.171N    |P=0.226N     P=0.760N     P=0.532N     P=0.554N     |
|POLY 1.5           |     P=0.071N     P=0.468N     P=0.297N     P=0.162N    |P=0.208N     P=0.759      P=0.518N     P=0.541N     |
|POLY 6             |     P=0.084N     P=0.428N     P=0.303N     P=0.181N    |P=0.249N     P=0.756N     P=0.550N     P=0.567N     |
|LOGISTIC REGRESSION|     P=0.027N*    P=0.547N     P=0.327N     P=0.162N    |P=0.199N     P=0.762      P=0.497N     P=0.520N     |
|COCH-ARM / FISHERS |     P=0.048N*    P=0.500N     P=0.309N     P=0.121N    |P=0.170N     P=0.753N     P=0.500N     P=0.500N     |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      250 PPB      500 PPB      750 PPB     |CONTROL      250 PPB      500 PPB      750 PPB      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Heart: Myocardium                                                                                                                |
|     Fibrosis                                                                                                                    |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     12/50 (24%)  10/50 (20%)  8/50 (16%)   7/50 (14%)  |3/50 (6%)    1/50 (2%)    4/50 (8%)    1/50 (2%)    |
|POLY-3 ADJUSTED (b)|     31.7%        24.7%        21.1%        24.4%       |7.2%         2.4%         11.1%        3.1%         |
|TERMINAL (d)       |     2/12 (17%)   4/14 (29%)   1/9 (11%)    2/6 (33%)   |3/26 (12%)   1/31 (3%)    3/15 (20%)   1/14 (7%)    |
|FIRST INCIDENCE    |     555          613          524          561         |730 (T)      730 (T)      676          730 (T)      |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.371N     P=0.257N     P=0.307N     P=0.429N    |P=0.421      P=0.243N     P=0.229      P=0.543N     |
|POLY 3             |     P=0.216N     P=0.328N     P=0.210N     P=0.351N    |P=0.532N     P=0.301N     P=0.419      P=0.406N     |
|POLY 1.5           |     P=0.192N     P=0.354N     P=0.211N     P=0.310N    |P=0.494N     P=0.306N     P=0.454      P=0.381N     |
|POLY 6             |     P=0.246N     P=0.300N     P=0.216N     P=0.399N    |P=0.569N     P=0.291N     P=0.376      P=0.430N     |
|LOGISTIC REGRESSION|     P=0.203N     P=0.323N     P=0.217N     P=0.323N    |P=0.510      P=0.243N     P=0.291      P=0.543N     |
|COCH-ARM / FISHERS |     P=0.096N     P=0.405N     P=0.227N     P=0.154N    |P=0.380N     P=0.309N     P=0.500      P=0.309N     |
|=================================================================================================================================|
       Date:  09/14/98                           EXPERIMENT: 05184 TEST: 05                                            Page 7
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                   GLUTARALDEHYDE
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      250 PPB      500 PPB      750 PPB     |CONTROL      250 PPB      500 PPB      750 PPB      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Intestine Large, Cecum                                                                                                           |
|     Parasite Metazoan                                                                                                           |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     3/47 (6%)    1/46 (2%)    9/48 (19%)   2/45 (4%)   |5/48 (10%)   4/48 (8%)    3/49 (6%)    3/49 (6%)    |
|POLY-3 ADJUSTED (b)|     8.7%         2.7%         24.8%        7.7%        |12.4%        9.7%         8.3%         9.4%         |
|TERMINAL (d)       |     0/11 (0%)    1/14 (7%)    4/9 (44%)    1/6 (17%)   |5/26 (19%)   4/31 (13%)   0/15 (0%)    1/14 (7%)    |
|FIRST INCIDENCE    |     498          729 (T)      524          683         |730 (T)      730 (T)      558          569          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.127      P=0.251N     P=0.051      P=0.637N    |P=0.511      P=0.388N     P=0.619N     P=0.633      |
|POLY 3             |     P=0.134      P=0.278N     P=0.065      P=0.626N    |P=0.358N     P=0.487N     P=0.419N     P=0.493N     |
|POLY 1.5           |     P=0.160      P=0.290N     P=0.066      P=0.608N    |P=0.318N     P=0.497N     P=0.386N     P=0.458N     |
|POLY 6             |     P=0.112      P=0.262N     P=0.063      P=0.642N    |P=0.401N     P=0.468N     P=0.461N     P=0.524N     |
|LOGISTIC REGRESSION|     P=0.225      P=0.356N     P=0.067      P=0.577N    |P=0.409N     P=0.388N     P=0.477N     P=0.543N     |
|COCH-ARM / FISHERS |     P=0.301      P=0.317N     P=0.065      P=0.521N    |P=0.224N     P=0.500N     P=0.346N     P=0.346N     |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      250 PPB      500 PPB      750 PPB     |CONTROL      250 PPB      500 PPB      750 PPB      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Intestine Large, Colon                                                                                                           |
|     Parasite Metazoan                                                                                                           |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     2/49 (4%)    3/48 (6%)    0/48 (0%)    0/45 (0%)   |2/48 (4%)    4/49 (8%)    1/49 (2%)    1/49 (2%)    |
|POLY-3 ADJUSTED (b)|     5.8%         7.8%         0.0%         0.0%        |4.9%         9.3%         2.8%         3.2%         |
|TERMINAL (d)       |     1/12 (8%)    2/14 (14%)   0/9 (0%)     0/6 (0%)    |2/26 (8%)    2/31 (7%)    0/15 (0%)    0/14 (0%)    |
|FIRST INCIDENCE    |     601          647          ---          ---         |730 (T)      589          558          630          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.100N     P=0.574      P=0.268N     P=0.351N    |P=0.399N     P=0.397      P=0.642N     P=0.673N     |
|POLY 3             |     P=0.077N     P=0.546      P=0.235N     P=0.307N    |P=0.317N     P=0.363      P=0.540N     P=0.585N     |
|POLY 1.5           |     P=0.074N     P=0.526      P=0.236N     P=0.300N    |P=0.282N     P=0.353      P=0.520N     P=0.563N     |
|POLY 6             |     P=0.080N     P=0.571      P=0.236N     P=0.313N    |P=0.357N     P=0.381      P=0.567N     P=0.603N     |
|LOGISTIC REGRESSION|     P=0.071N     P=0.564      P=0.235N     P=0.299N    |P=0.229N     P=0.346      P=0.513N     P=0.595N     |
|COCH-ARM / FISHERS |     P=0.059N     P=0.490      P=0.253N     P=0.269N    |P=0.204N     P=0.349      P=0.492N     P=0.492N     |
|=================================================================================================================================|
       Date:  09/14/98                           EXPERIMENT: 05184 TEST: 05                                            Page 8
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                   GLUTARALDEHYDE
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      250 PPB      500 PPB      750 PPB     |CONTROL      250 PPB      500 PPB      750 PPB      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Intestine Large, Rectum                                                                                                          |
|     Parasite Metazoan                                                                                                           |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     0/50 (0%)    4/48 (8%)    2/49 (4%)    3/46 (7%)   |3/48 (6%)    4/50 (8%)    4/49 (8%)    0/49 (0%)    |
|POLY-3 ADJUSTED (b)|     0.0%         10.5%        5.7%         11.3%       |7.4%         9.4%         10.9%        0.0%         |
|TERMINAL (d)       |     0/12 (0%)    3/14 (21%)   2/9 (22%)    3/6 (50%)   |2/26 (8%)    2/31 (7%)    2/15 (13%)   0/14 (0%)    |
|FIRST INCIDENCE    |     ---          708          729 (T)      729 (T)     |638          593          357          ---          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.030 *    P=0.088      P=0.173      P=0.025 *   |P=0.336N     P=0.560      P=0.296      P=0.230N     |
|POLY 3             |     P=0.120      P=0.070      P=0.237      P=0.074     |P=0.271N     P=0.525      P=0.440      P=0.174N     |
|POLY 1.5           |     P=0.125      P=0.064      P=0.237      P=0.078     |P=0.227N     P=0.519      P=0.473      P=0.157N     |
|POLY 6             |     P=0.113      P=0.077      P=0.235      P=0.070     |P=0.321N     P=0.538      P=0.396      P=0.191N     |
|LOGISTIC REGRESSION|     P=0.046 *    P=0.085      P=0.173      P=0.025 *   |P=0.161N     P=0.520      P=0.516      P=0.171N     |
|COCH-ARM / FISHERS |     P=0.159      P=0.054      P=0.242      P=0.106     |P=0.129N     P=0.523      P=0.512      P=0.117N     |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      250 PPB      500 PPB      750 PPB     |CONTROL      250 PPB      500 PPB      750 PPB      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Kidney                                                                                                                           |
|     Cyst                                                                                                                        |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     0/50 (0%)    2/50 (4%)    1/50 (2%)    2/50 (4%)   |0/49 (0%)    0/50 (0%)    0/50 (0%)    1/50 (2%)    |
|POLY-3 ADJUSTED (b)|     0.0%         5.0%         2.8%         7.3%        |0.0%         0.0%         0.0%         3.1%         |
|TERMINAL (d)       |     0/12 (0%)    0/14 (0%)    0/9 (0%)     2/6 (33%)   |0/26 (0%)    0/31 (0%)    0/15 (0%)    0/14 (0%)    |
|FIRST INCIDENCE    |     ---          356          593          729 (T)     |---          ---          ---          654          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.110      P=0.275      P=0.511      P=0.099     |P=0.146      (e)          (e)          P=0.432      |
|POLY 3             |     P=0.178      P=0.265      P=0.505      P=0.187     |P=0.199      (e)          (e)          P=0.453      |
|POLY 1.5           |     P=0.181      P=0.255      P=0.504      P=0.194     |P=0.199      (e)          (e)          P=0.465      |
|POLY 6             |     P=0.174      P=0.279      P=0.506      P=0.180     |P=0.198      (e)          (e)          P=0.442      |
|LOGISTIC REGRESSION|     P=0.191      P=0.151      P=0.488      P=0.099     |P=0.171      (e)          (e)          P=0.481      |
|COCH-ARM / FISHERS |     P=0.209      P=0.247      P=0.500      P=0.247     |P=0.186      (e)          (e)          P=0.505      |
|=================================================================================================================================|
       Date:  09/14/98                           EXPERIMENT: 05184 TEST: 05                                            Page 9
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                   GLUTARALDEHYDE
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      250 PPB      500 PPB      750 PPB     |CONTROL      250 PPB      500 PPB      750 PPB      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Kidney                                                                                                                           |
|     Mineralization                                                                                                              |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     3/50 (6%)    1/50 (2%)    0/50 (0%)    0/50 (0%)   |1/49 (2%)    0/50 (0%)    0/50 (0%)    0/50 (0%)    |
|POLY-3 ADJUSTED (b)|     8.5%         2.6%         0.0%         0.0%        |2.4%         0.0%         0.0%         0.0%         |
|TERMINAL (d)       |     1/12 (8%)    0/14 (0%)    0/9 (0%)     0/6 (0%)    |1/26 (4%)    0/31 (0%)    0/15 (0%)    0/14 (0%)    |
|FIRST INCIDENCE    |     689          579          ---          ---         |730 (T)      ---          ---          ---          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.035N*    P=0.246N     P=0.163N     P=0.202N    |P=0.252N     P=0.465N     P=0.610N     P=0.623N     |
|POLY 3             |     P=0.027N*    P=0.267N     P=0.115N     P=0.167N    |P=0.212N     P=0.494N     P=0.527N     P=0.549N     |
|POLY 1.5           |     P=0.026N*    P=0.281N     P=0.116N     P=0.160N    |P=0.202N     P=0.497N     P=0.514N     P=0.536N     |
|POLY 6             |     P=0.029N*    P=0.249N     P=0.117N     P=0.174N    |P=0.224N     P=0.489N     P=0.544N     P=0.561N     |
|LOGISTIC REGRESSION|     P=0.026N*    P=0.270N     P=0.124N     P=0.176N    |P=0.252N     (e)          (e)          (e)          |
|COCH-ARM / FISHERS |     P=0.021N*    P=0.309N     P=0.121N     P=0.121N    |P=0.183N     P=0.495N     P=0.495N     P=0.495N     |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      250 PPB      500 PPB      750 PPB     |CONTROL      250 PPB      500 PPB      750 PPB      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Kidney                                                                                                                           |
|     Nephropathy Chronic                                                                                                         |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     39/50 (78%)  48/50 (96%)  48/50 (96%)  38/50 (76%) |3/50 (6%)    0/50 (0%)    0/50 (0%)    0/50 (0%)    |
|POLY-3 ADJUSTED (b)|     86.4%        97.9%        98.7%        97.1%       |8.3%         0.0%         0.0%         0.0%         |
|TERMINAL (d)       |     11/12 (92%)  14/14 (100%) 9/9 (100%)   6/6 (100%)  |0/12 (0%)    0/14 (0%)    0/9 (0%)     0/6 (0%)     |
|FIRST INCIDENCE    |     392          356          393          393         |495          ---          ---          ---          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.021 *    P=0.463      P=0.083      P=0.067     |P=0.023N*    P=0.093N     P=0.128N     P=0.169N     |
|POLY 3             |     P=0.004 **   P=0.019 *    P=0.010 *    P=0.055     |P=0.021N*    P=0.106N     P=0.120N     P=0.174N     |
|POLY 1.5           |     P=0.007 **   P=0.014 *    P=0.008 **   P=0.064     |P=0.020N*    P=0.110N     P=0.118N     P=0.164N     |
|POLY 6             |     P=0.009 **   P=0.034 *    P=0.022 *    P=0.101     |P=0.022N*    P=0.101N     P=0.125N     P=0.185N     |
|LOGISTIC REGRESSION|     P=0.008 **   P=0.019 *    P=0.010 *    P=0.039 *   |P=0.015N*    P=0.137N     P=0.126N     P=0.128N     |
|COCH-ARM / FISHERS |     P=0.427N     P=0.007 **   P=0.007 **   P=0.500N    |P=0.019N*    P=0.121N     P=0.121N     P=0.121N     |
|=================================================================================================================================|
       Date:  09/14/98                           EXPERIMENT: 05184 TEST: 05                                            Page 10
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                   GLUTARALDEHYDE
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      250 PPB      500 PPB      750 PPB     |CONTROL      250 PPB      500 PPB      750 PPB      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Larynx                                                                                                                           |
|     Foreign Body                                                                                                                |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     1/50 (2%)    2/50 (4%)    3/50 (6%)    2/50 (4%)   |4/49 (8%)    3/50 (6%)    2/50 (4%)    6/49 (12%)   |
|POLY-3 ADJUSTED (b)|     2.9%         5.1%         8.1%         6.9%        |9.7%         7.0%         5.5%         16.8%        |
|TERMINAL (d)       |     1/12 (8%)    1/14 (7%)    0/9 (0%)     0/6 (0%)    |2/26 (8%)    1/31 (3%)    1/15 (7%)    0/14 (0%)    |
|FIRST INCIDENCE    |     729 (T)      666          526          262         |666          589          614          32           |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.190      P=0.567      P=0.294      P=0.372     |P=0.141      P=0.448N     P=0.536N     P=0.199      |
|POLY 3             |     P=0.243      P=0.537      P=0.324      P=0.432     |P=0.238      P=0.478N     P=0.399N     P=0.281      |
|POLY 1.5           |     P=0.249      P=0.523      P=0.318      P=0.438     |P=0.264      P=0.487N     P=0.368N     P=0.299      |
|POLY 6             |     P=0.240      P=0.556      P=0.333      P=0.431     |P=0.209      P=0.460N     P=0.441N     P=0.269      |
|LOGISTIC REGRESSION|     P=0.354      P=0.566      P=0.292      P=0.543     |P=0.496      P=0.490N     P=0.417N     P=0.598      |
|COCH-ARM / FISHERS |     P=0.314      P=0.500      P=0.309      P=0.500     |P=0.315      P=0.489N     P=0.329N     P=0.370      |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      250 PPB      500 PPB      750 PPB     |CONTROL      250 PPB      500 PPB      750 PPB      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Larynx: Epiglottis                                                                                                               |
|     Inflammation                                                                                                                |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     1/50 (2%)    0/50 (0%)    0/50 (0%)    1/50 (2%)   |1/49 (2%)    0/50 (0%)    2/50 (4%)    5/49 (10%)   |
|POLY-3 ADJUSTED (b)|     2.8%         0.0%         0.0%         3.5%        |2.4%         0.0%         5.5%         15.1%        |
|TERMINAL (d)       |     0/12 (0%)    0/14 (0%)    0/9 (0%)     0/6 (0%)    |1/26 (4%)    0/31 (0%)    1/15 (7%)    2/14 (14%)   |
|FIRST INCIDENCE    |     702          ---          ---          468         |730 (T)      ---          543          113          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.577      P=0.460N     P=0.523N     P=0.708     |P=0.003 **   P=0.465N     P=0.361      P=0.033 *    |
|POLY 3             |     P=0.641N     P=0.481N     P=0.498N     P=0.711     |P=0.011 *    P=0.494N     P=0.458      P=0.059      |
|POLY 1.5           |     P=0.636N     P=0.488N     P=0.497N     P=0.716     |P=0.013 *    P=0.497N     P=0.479      P=0.067      |
|POLY 6             |     P=0.639      P=0.472N     P=0.501N     P=0.708     |P=0.009 **   P=0.489N     P=0.432      P=0.052      |
|LOGISTIC REGRESSION|     P=0.600N     P=0.465N     P=0.505N     P=0.767     |P=0.019 *    (e)          P=0.490      P=0.103      |
|COCH-ARM / FISHERS |     P=0.625      P=0.500N     P=0.500N     P=0.753N    |P=0.018 *    P=0.495N     P=0.508      P=0.102      |
|=================================================================================================================================|
       Date:  09/14/98                           EXPERIMENT: 05184 TEST: 05                                            Page 11
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                   GLUTARALDEHYDE
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      250 PPB      500 PPB      750 PPB     |CONTROL      250 PPB      500 PPB      750 PPB      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Larynx: Glands                                                                                                                   |
|     Inflammation                                                                                                                |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     28/50 (56%)  18/50 (36%)  18/50 (36%)  26/50 (52%) |20/49 (41%)  16/50 (32%)  18/50 (36%)  19/49 (39%)  |
|POLY-3 ADJUSTED (b)|     65.5%        42.5%        45.2%        70.5%       |47.1%        36.4%        44.7%        50.1%        |
|TERMINAL (d)       |     7/12 (58%)   6/14 (43%)   4/9 (44%)    2/6 (33%)   |12/26 (46%)  10/31 (32%)  5/15 (33%)   5/14 (36%)   |
|FIRST INCIDENCE    |     452          495          526          100         |598          542          455          113          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.150      P=0.021N*    P=0.122N     P=0.205     |P=0.034 *    P=0.149N     P=0.200      P=0.108      |
|POLY 3             |     P=0.432      P=0.020N*    P=0.040N*    P=0.399     |P=0.355      P=0.210N     P=0.500N     P=0.484      |
|POLY 1.5           |     P=0.484      P=0.023N*    P=0.033N*    P=0.448     |P=0.388      P=0.231N     P=0.451N     P=0.492      |
|POLY 6             |     P=0.379      P=0.020N*    P=0.057N     P=0.372     |P=0.337      P=0.179N     P=0.557N     P=0.508      |
|LOGISTIC REGRESSION|     P=0.505      P=0.025N*    P=0.030N*    P=0.505     |P=0.339      P=0.228N     P=0.567N     P=0.453      |
|COCH-ARM / FISHERS |     P=0.375N     P=0.035N*    P=0.035N*    P=0.421N    |P=0.500N     P=0.241N     P=0.387N     P=0.500N     |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      250 PPB      500 PPB      750 PPB     |CONTROL      250 PPB      500 PPB      750 PPB      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Larynx: Squamous Epithelium                                                                                                      |
|     Hyperplasia                                                                                                                 |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     1/50 (2%)    0/50 (0%)    1/50 (2%)    1/50 (2%)   |5/49 (10%)   1/50 (2%)    1/50 (2%)    0/49 (0%)    |
|POLY-3 ADJUSTED (b)|     2.8%         0.0%         2.8%         3.6%        |12.0%        2.4%         2.8%         0.0%         |
|TERMINAL (d)       |     0/12 (0%)    0/14 (0%)    0/9 (0%)     0/6 (0%)    |3/26 (12%)   1/31 (3%)    0/15 (0%)    0/14 (0%)    |
|FIRST INCIDENCE    |     702          ---          721          589         |598          730 (T)      634          ---          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.410      P=0.460N     P=0.737      P=0.712     |P=0.028N*    P=0.081N     P=0.215N     P=0.099N     |
|POLY 3             |     P=0.467      P=0.481N     P=0.759N     P=0.708     |P=0.013N*    P=0.098N     P=0.136N     P=0.061N     |
|POLY 1.5           |     P=0.472      P=0.488N     P=0.758N     P=0.714     |P=0.011N*    P=0.099N     P=0.118N     P=0.052N     |
|POLY 6             |     P=0.460      P=0.472N     P=0.763      P=0.706     |P=0.016N*    P=0.094N     P=0.163N     P=0.072N     |
|LOGISTIC REGRESSION|     P=0.442      P=0.465N     P=0.754      P=0.722     |P=0.012N*    P=0.098N     P=0.118N     P=0.054N     |
|COCH-ARM / FISHERS |     P=0.500      P=0.500N     P=0.753N     P=0.753N    |P=0.008N**   P=0.098N     P=0.098N     P=0.028N*    |
|=================================================================================================================================|
       Date:  09/14/98                           EXPERIMENT: 05184 TEST: 05                                            Page 12
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                   GLUTARALDEHYDE
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      250 PPB      500 PPB      750 PPB     |CONTROL      250 PPB      500 PPB      750 PPB      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Liver                                                                                                                            |
|     Angiectasis                                                                                                                 |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     2/50 (4%)    2/50 (4%)    1/50 (2%)    3/50 (6%)   |1/50 (2%)    0/50 (0%)    2/50 (4%)    0/50 (0%)    |
|POLY-3 ADJUSTED (b)|     5.6%         5.1%         2.8%         10.7%       |2.4%         0.0%         5.5%         0.0%         |
|TERMINAL (d)       |     1/12 (8%)    1/14 (7%)    0/9 (0%)     0/6 (0%)    |0/26 (0%)    0/31 (0%)    0/15 (0%)    0/14 (0%)    |
|FIRST INCIDENCE    |     602          647          726          638         |589          ---          617          ---          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.256      P=0.630N     P=0.548N     P=0.349     |P=0.595      P=0.500N     P=0.410      P=0.570N     |
|POLY 3             |     P=0.393      P=0.661N     P=0.499N     P=0.392     |P=0.616N     P=0.500N     P=0.446      P=0.555N     |
|POLY 1.5           |     P=0.401      P=0.673N     P=0.497N     P=0.407     |P=0.589N     P=0.502N     P=0.469      P=0.541N     |
|POLY 6             |     P=0.379      P=0.645N     P=0.507N     P=0.383     |P=0.605      P=0.496N     P=0.418      P=0.568N     |
|LOGISTIC REGRESSION|     P=0.321      P=0.661N     P=0.499N     P=0.383     |P=0.506N     P=0.488N     P=0.513      P=0.474N     |
|COCH-ARM / FISHERS |     P=0.436      P=0.691N     P=0.500N     P=0.500     |P=0.500N     P=0.500N     P=0.500      P=0.500N     |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      250 PPB      500 PPB      750 PPB     |CONTROL      250 PPB      500 PPB      750 PPB      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Liver                                                                                                                            |
|     Basophilic Focus                                                                                                            |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     1/50 (2%)    1/50 (2%)    0/50 (0%)    0/50 (0%)   |2/50 (4%)    2/50 (4%)    3/50 (6%)    3/50 (6%)    |
|POLY-3 ADJUSTED (b)|     2.8%         2.6%         0.0%         0.0%        |4.8%         4.8%         8.3%         9.3%         |
|TERMINAL (d)       |     0/12 (0%)    1/14 (7%)    0/9 (0%)     0/6 (0%)    |1/26 (4%)    2/31 (7%)    1/15 (7%)    1/14 (7%)    |
|FIRST INCIDENCE    |     556          729 (T)      ---          ---         |660          730 (T)      617          698          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.221N     P=0.730N     P=0.495N     P=0.538N    |P=0.115      P=0.646N     P=0.326      P=0.280      |
|POLY 3             |     P=0.209N     P=0.743N     P=0.500N     P=0.551N    |P=0.228      P=0.693N     P=0.434      P=0.380      |
|POLY 1.5           |     P=0.202N     P=0.749N     P=0.499N     P=0.543N    |P=0.255      P=0.692      P=0.462      P=0.409      |
|POLY 6             |     P=0.216N     P=0.735N     P=0.505N     P=0.558N    |P=0.202      P=0.686N     P=0.400      P=0.354      |
|LOGISTIC REGRESSION|     P=0.179N     P=0.763      P=0.529N     P=0.485N    |P=0.191      P=0.684N     P=0.444      P=0.350      |
|COCH-ARM / FISHERS |     P=0.170N     P=0.753N     P=0.500N     P=0.500N    |P=0.332      P=0.691N     P=0.500      P=0.500      |
|=================================================================================================================================|
       Date:  09/14/98                           EXPERIMENT: 05184 TEST: 05                                            Page 13
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                   GLUTARALDEHYDE
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      250 PPB      500 PPB      750 PPB     |CONTROL      250 PPB      500 PPB      750 PPB      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Liver                                                                                                                            |
|     Clear Cell Focus                                                                                                            |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     0/50 (0%)    4/50 (8%)    3/50 (6%)    1/50 (2%)   |6/50 (12%)   7/50 (14%)   6/50 (12%)   4/50 (8%)    |
|POLY-3 ADJUSTED (b)|     0.0%         10.3%        8.3%         3.6%        |14.2%        16.3%        15.9%        12.0%        |
|TERMINAL (d)       |     0/12 (0%)    3/14 (21%)   1/9 (11%)    0/6 (0%)    |3/26 (12%)   5/31 (16%)   1/15 (7%)    2/14 (14%)   |
|FIRST INCIDENCE    |     ---          666          617          638         |666          589          508          474          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.239      P=0.086      P=0.106      P=0.452     |P=0.403      P=0.587      P=0.350      P=0.590      |
|POLY 3             |     P=0.314      P=0.073      P=0.122      P=0.455     |P=0.468N     P=0.513      P=0.539      P=0.525N     |
|POLY 1.5           |     P=0.327      P=0.068      P=0.122      P=0.460     |P=0.416N     P=0.501      P=0.574      P=0.489N     |
|POLY 6             |     P=0.307      P=0.080      P=0.121      P=0.452     |P=0.527N     P=0.535      P=0.494      P=0.560N     |
|LOGISTIC REGRESSION|     P=0.315      P=0.087      P=0.120      P=0.466     |P=0.360N     P=0.504      P=0.591      P=0.474N     |
|COCH-ARM / FISHERS |     P=0.436      P=0.059      P=0.121      P=0.500     |P=0.276N     P=0.500      P=0.620N     P=0.370N     |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      250 PPB      500 PPB      750 PPB     |CONTROL      250 PPB      500 PPB      750 PPB      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Liver                                                                                                                            |
|     Hepatodiaphragmatic Nodule                                                                                                  |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     1/50 (2%)    2/50 (4%)    0/50 (0%)    0/50 (0%)   |3/50 (6%)    6/50 (12%)   3/50 (6%)    3/50 (6%)    |
|POLY-3 ADJUSTED (b)|     2.8%         5.1%         0.0%         0.0%        |7.0%         14.3%        8.2%         9.0%         |
|TERMINAL (d)       |     0/12 (0%)    1/14 (7%)    0/9 (0%)     0/6 (0%)    |1/26 (4%)    6/31 (19%)   0/15 (0%)    0/14 (0%)    |
|FIRST INCIDENCE    |     580          671          ---          ---         |119          730 (T)      508          113          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.206N     P=0.549      P=0.495N     P=0.546N    |P=0.365      P=0.315      P=0.527      P=0.490      |
|POLY 3             |     P=0.192N     P=0.532      P=0.500N     P=0.550N    |P=0.520      P=0.231      P=0.589      P=0.539      |
|POLY 1.5           |     P=0.185N     P=0.520      P=0.498N     P=0.542N    |P=0.540N     P=0.228      P=0.618      P=0.569      |
|POLY 6             |     P=0.201N     P=0.547      P=0.504N     P=0.558N    |P=0.470      P=0.239      P=0.554      P=0.511      |
|LOGISTIC REGRESSION|     P=0.169N     P=0.516      P=0.518N     P=0.501N    |P=0.348N     P=0.246      P=0.579N     P=0.466N     |
|COCH-ARM / FISHERS |     P=0.149N     P=0.500      P=0.500N     P=0.500N    |P=0.405N     P=0.243      P=0.661N     P=0.661N     |
|=================================================================================================================================|
       Date:  09/14/98                           EXPERIMENT: 05184 TEST: 05                                            Page 14
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                   GLUTARALDEHYDE
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      250 PPB      500 PPB      750 PPB     |CONTROL      250 PPB      500 PPB      750 PPB      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Liver                                                                                                                            |
|     Necrosis                                                                                                                    |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     1/50 (2%)    2/50 (4%)    1/50 (2%)    0/50 (0%)   |2/50 (4%)    0/50 (0%)    0/50 (0%)    0/50 (0%)    |
|POLY-3 ADJUSTED (b)|     2.8%         5.1%         2.8%         0.0%        |4.7%         0.0%         0.0%         0.0%         |
|TERMINAL (d)       |     0/12 (0%)    0/14 (0%)    0/9 (0%)     0/6 (0%)    |0/26 (0%)    0/31 (0%)    0/15 (0%)    0/14 (0%)    |
|FIRST INCIDENCE    |     657          550          716          ---         |550          ---          ---          ---          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.327N     P=0.564      P=0.748      P=0.557N    |P=0.086N     P=0.218N     P=0.317N     P=0.349N     |
|POLY 3             |     P=0.340N     P=0.538      P=0.760N     P=0.549N    |P=0.068N     P=0.238N     P=0.276N     P=0.305N     |
|POLY 1.5           |     P=0.325N     P=0.524      P=0.758N     P=0.542N    |P=0.063N     P=0.240N     P=0.259N     P=0.287N     |
|POLY 6             |     P=0.356N     P=0.557      P=0.761      P=0.556N    |P=0.075N     P=0.233N     P=0.300N     P=0.323N     |
|LOGISTIC REGRESSION|     P=0.283N     P=0.487      P=0.763N     P=0.543N    |P=0.049N*    P=0.232N     P=0.223N     P=0.238N     |
|COCH-ARM / FISHERS |     P=0.249N     P=0.500      P=0.753N     P=0.500N    |P=0.056N     P=0.247N     P=0.247N     P=0.247N     |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      250 PPB      500 PPB      750 PPB     |CONTROL      250 PPB      500 PPB      750 PPB      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Liver                                                                                                                            |
|     Vacuolization Cytoplasmic                                                                                                   |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     7/50 (14%)   1/50 (2%)    2/50 (4%)    1/50 (2%)   |5/50 (10%)   1/50 (2%)    0/50 (0%)    3/50 (6%)    |
|POLY-3 ADJUSTED (b)|     19.1%        2.6%         5.4%         3.6%        |11.8%        2.4%         0.0%         9.0%         |
|TERMINAL (d)       |     1/12 (8%)    0/14 (0%)    0/9 (0%)     0/6 (0%)    |2/26 (8%)    1/31 (3%)    0/15 (0%)    0/14 (0%)    |
|FIRST INCIDENCE    |     495          694          525          561         |651          730 (T)      ---          516          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.030N*    P=0.019N*    P=0.104N     P=0.080N    |P=0.366N     P=0.087N     P=0.092N     P=0.591N     |
|POLY 3             |     P=0.020N*    P=0.022N*    P=0.073N     P=0.066N    |P=0.223N     P=0.102N     P=0.047N*    P=0.492N     |
|POLY 1.5           |     P=0.019N*    P=0.025N*    P=0.074N     P=0.060N    |P=0.204N     P=0.104N     P=0.039N*    P=0.462N     |
|POLY 6             |     P=0.021N*    P=0.020N*    P=0.075N     P=0.073N    |P=0.250N     P=0.097N     P=0.060N     P=0.519N     |
|LOGISTIC REGRESSION|     P=0.014N*    P=0.026N*    P=0.082N     P=0.055N    |P=0.211N     P=0.100N     P=0.049N*    P=0.417N     |
|COCH-ARM / FISHERS |     P=0.013N*    P=0.030N*    P=0.080N     P=0.030N*   |P=0.180N     P=0.102N     P=0.028N*    P=0.357N     |
|=================================================================================================================================|
       Date:  09/14/98                           EXPERIMENT: 05184 TEST: 05                                            Page 15
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                   GLUTARALDEHYDE
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      250 PPB      500 PPB      750 PPB     |CONTROL      250 PPB      500 PPB      750 PPB      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Liver: Bile Duct                                                                                                                 |
|     Hyperplasia                                                                                                                 |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     3/50 (6%)    0/50 (0%)    0/50 (0%)    2/50 (4%)   |0/50 (0%)    0/50 (0%)    0/50 (0%)    0/50 (0%)    |
|POLY-3 ADJUSTED (b)|     8.4%         0.0%         0.0%         7.1%        |0.0%         0.0%         0.0%         0.0%         |
|TERMINAL (d)       |     1/12 (8%)    0/14 (0%)    0/9 (0%)     0/6 (0%)    |0/26 (0%)    0/31 (0%)    0/15 (0%)    0/14 (0%)    |
|FIRST INCIDENCE    |     638          ---          ---          502         |---          ---          ---          ---          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.448N     P=0.095N     P=0.130N     P=0.645N    |(e)          (e)          (e)          (e)          |
|POLY 3             |     P=0.354N     P=0.103N     P=0.117N     P=0.605N    |(e)          (e)          (e)          (e)          |
|POLY 1.5           |     P=0.349N     P=0.109N     P=0.117N     P=0.591N    |(e)          (e)          (e)          (e)          |
|POLY 6             |     P=0.362N     P=0.097N     P=0.121N     P=0.617N    |(e)          (e)          (e)          (e)          |
|LOGISTIC REGRESSION|     P=0.381N     P=0.104N     P=0.118N     P=0.587N    |(e)          (e)          (e)          (e)          |
|COCH-ARM / FISHERS |     P=0.343N     P=0.121N     P=0.121N     P=0.500N    |(e)          (e)          (e)          (e)          |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      250 PPB      500 PPB      750 PPB     |CONTROL      250 PPB      500 PPB      750 PPB      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Liver: Hepatocyte                                                                                                                |
|     Degeneration Focal                                                                                                          |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     3/50 (6%)    0/50 (0%)    0/50 (0%)    1/50 (2%)   |0/50 (0%)    0/50 (0%)    0/50 (0%)    0/50 (0%)    |
|POLY-3 ADJUSTED (b)|     8.4%         0.0%         0.0%         3.6%        |0.0%         0.0%         0.0%         0.0%         |
|TERMINAL (d)       |     1/12 (8%)    0/14 (0%)    0/9 (0%)     0/6 (0%)    |0/26 (0%)    0/31 (0%)    0/15 (0%)    0/14 (0%)    |
|FIRST INCIDENCE    |     638          ---          ---          708         |---          ---          ---          ---          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.191N     P=0.095N     P=0.147N     P=0.441N    |(e)          (e)          (e)          (e)          |
|POLY 3             |     P=0.138N     P=0.103N     P=0.117N     P=0.399N    |(e)          (e)          (e)          (e)          |
|POLY 1.5           |     P=0.136N     P=0.108N     P=0.116N     P=0.384N    |(e)          (e)          (e)          (e)          |
|POLY 6             |     P=0.141N     P=0.096N     P=0.119N     P=0.413N    |(e)          (e)          (e)          (e)          |
|LOGISTIC REGRESSION|     P=0.164N     P=0.098N     P=0.119N     P=0.406N    |(e)          (e)          (e)          (e)          |
|COCH-ARM / FISHERS |     P=0.129N     P=0.121N     P=0.121N     P=0.309N    |(e)          (e)          (e)          (e)          |
|=================================================================================================================================|
       Date:  09/14/98                           EXPERIMENT: 05184 TEST: 05                                            Page 16
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                   GLUTARALDEHYDE
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      250 PPB      500 PPB      750 PPB     |CONTROL      250 PPB      500 PPB      750 PPB      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Lung: Alveolar Epithelium                                                                                                        |
|     Hyperplasia                                                                                                                 |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     9/50 (18%)   3/50 (6%)    5/50 (10%)   4/50 (8%)   |7/50 (14%)   4/50 (8%)    2/50 (4%)    4/49 (8%)    |
|POLY-3 ADJUSTED (b)|     24.1%        7.6%         13.2%        13.3%       |16.8%        9.5%         5.5%         12.0%        |
|TERMINAL (d)       |     1/12 (8%)    1/14 (7%)    0/9 (0%)     0/6 (0%)    |7/26 (27%)   4/31 (13%)   1/15 (7%)    0/14 (0%)    |
|FIRST INCIDENCE    |     555          617          481          100         |730 (T)      730 (T)      617          514          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.235N     P=0.039N*    P=0.232N     P=0.266N    |P=0.436N     P=0.161N     P=0.252N     P=0.591N     |
|POLY 3             |     P=0.166N     P=0.044N*    P=0.177N     P=0.209N    |P=0.208N     P=0.253N     P=0.115N     P=0.403N     |
|POLY 1.5           |     P=0.158N     P=0.049N*    P=0.179N     P=0.195N    |P=0.184N     P=0.262N     P=0.099N     P=0.379N     |
|POLY 6             |     P=0.176N     P=0.039N*    P=0.182N     P=0.224N    |P=0.234N     P=0.236N     P=0.139N     P=0.418N     |
|LOGISTIC REGRESSION|     P=0.080N     P=0.052N     P=0.196N     P=0.124N    |P=0.248N     P=0.161N     P=0.180N     P=0.413N     |
|COCH-ARM / FISHERS |     P=0.108N     P=0.061N     P=0.194N     P=0.117N    |P=0.134N     P=0.262N     P=0.080N     P=0.274N     |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      250 PPB      500 PPB      750 PPB     |CONTROL      250 PPB      500 PPB      750 PPB      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Lung: Alveolus                                                                                                                   |
|     Emphysema                                                                                                                   |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     1/50 (2%)    0/50 (0%)    0/50 (0%)    0/50 (0%)   |0/50 (0%)    0/50 (0%)    0/50 (0%)    2/49 (4%)    |
|POLY-3 ADJUSTED (b)|     2.9%         0.0%         0.0%         0.0%        |0.0%         0.0%         0.0%         6.2%         |
|TERMINAL (d)       |     1/12 (8%)    0/14 (0%)    0/9 (0%)     0/6 (0%)    |0/26 (0%)    0/31 (0%)    0/15 (0%)    0/14 (0%)    |
|FIRST INCIDENCE    |     729 (T)      ---          ---          ---         |---          ---          ---          474          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.241N     P=0.469N     P=0.557N     P=0.638N    |P=0.032 *    (e)          (e)          P=0.170      |
|POLY 3             |     P=0.212N     P=0.480N     P=0.497N     P=0.548N    |P=0.054      (e)          (e)          P=0.186      |
|POLY 1.5           |     P=0.207N     P=0.488N     P=0.497N     P=0.541N    |P=0.056      (e)          (e)          P=0.195      |
|POLY 6             |     P=0.219N     P=0.470N     P=0.499N     P=0.553N    |P=0.051      (e)          (e)          P=0.177      |
|LOGISTIC REGRESSION|     P=0.241N     (e)          (e)          (e)         |P=0.060      (e)          (e)          P=0.243      |
|COCH-ARM / FISHERS |     P=0.185N     P=0.500N     P=0.500N     P=0.500N    |P=0.055      (e)          (e)          P=0.242      |
|=================================================================================================================================|
       Date:  09/14/98                           EXPERIMENT: 05184 TEST: 05                                            Page 17
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                   GLUTARALDEHYDE
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      250 PPB      500 PPB      750 PPB     |CONTROL      250 PPB      500 PPB      750 PPB      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Lung: Alveolus                                                                                                                   |
|     Hemorrhage                                                                                                                  |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     3/50 (6%)    2/50 (4%)    1/50 (2%)    1/50 (2%)   |1/50 (2%)    0/50 (0%)    1/50 (2%)    0/49 (0%)    |
|POLY-3 ADJUSTED (b)|     8.5%         5.1%         2.8%         3.6%        |2.4%         0.0%         2.8%         0.0%         |
|TERMINAL (d)       |     1/12 (8%)    0/14 (0%)    0/9 (0%)     1/6 (17%)   |1/26 (4%)    0/31 (0%)    0/15 (0%)    0/14 (0%)    |
|FIRST INCIDENCE    |     637          569          561          729 (T)     |730 (T)      ---          533          ---          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.245N     P=0.417N     P=0.337N     P=0.489N    |P=0.483N     P=0.465N     P=0.687      P=0.623N     |
|POLY 3             |     P=0.203N     P=0.453N     P=0.297N     P=0.400N    |P=0.457N     P=0.498N     P=0.729      P=0.554N     |
|POLY 1.5           |     P=0.194N     P=0.471N     P=0.298N     P=0.385N    |P=0.438N     P=0.501N     P=0.743      P=0.543N     |
|POLY 6             |     P=0.214N     P=0.431N     P=0.299N     P=0.415N    |P=0.474N     P=0.493N     P=0.712      P=0.565N     |
|LOGISTIC REGRESSION|     P=0.191N     P=0.466N     P=0.301N     P=0.411N    |P=0.367N     (e)          P=0.750N     (e)          |
|COCH-ARM / FISHERS |     P=0.151N     P=0.500N     P=0.309N     P=0.309N    |P=0.379N     P=0.500N     P=0.753N     P=0.505N     |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      250 PPB      500 PPB      750 PPB     |CONTROL      250 PPB      500 PPB      750 PPB      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Lung: Alveolus                                                                                                                   |
|     Infiltration Cellular Histiocyte                                                                                            |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     23/50 (46%)  15/50 (30%)  14/50 (28%)  11/50 (22%) |29/50 (58%)  24/50 (48%)  22/50 (44%)  35/49 (71%)  |
|POLY-3 ADJUSTED (b)|     56.3%        36.7%        35.6%        35.5%       |64.0%        53.5%        54.0%        90.7%        |
|TERMINAL (d)       |     7/12 (58%)   4/14 (29%)   1/9 (11%)    2/6 (33%)   |17/26 (65%)  17/31 (55%)  7/15 (47%)   13/14 (93%)  |
|FIRST INCIDENCE    |     392          613          481          468         |542          178          355          117          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.153N     P=0.036N*    P=0.132N     P=0.181N    |P<0.001 **   P=0.099N     P=0.359      P<0.001 **   |
|POLY 3             |     P=0.030N*    P=0.050N     P=0.041N*    P=0.057N    |P=0.011 *    P=0.205N     P=0.224N     P=0.002 **   |
|POLY 1.5           |     P=0.026N*    P=0.056N     P=0.041N*    P=0.046N*   |P=0.025 *    P=0.208N     P=0.166N     P=0.006 **   |
|POLY 6             |     P=0.034N*    P=0.044N*    P=0.043N*    P=0.067N    |P=0.006 **   P=0.199N     P=0.308N     P<0.001 **   |
|LOGISTIC REGRESSION|     P=0.027N*    P=0.042N*    P=0.044N*    P=0.042N*   |P=0.015 *    P=0.215N     P=0.220N     P=0.003 **   |
|COCH-ARM / FISHERS |     P=0.007N**   P=0.074N     P=0.048N*    P=0.010N*   |P=0.144      P=0.212N     P=0.115N     P=0.117      |
|=================================================================================================================================|
       Date:  09/14/98                           EXPERIMENT: 05184 TEST: 05                                            Page 18
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                   GLUTARALDEHYDE
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      250 PPB      500 PPB      750 PPB     |CONTROL      250 PPB      500 PPB      750 PPB      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Lung: Alveolus                                                                                                                   |
|     Inflammation                                                                                                                |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     0/50 (0%)    2/50 (4%)    0/50 (0%)    2/50 (4%)   |2/50 (4%)    1/50 (2%)    0/50 (0%)    1/49 (2%)    |
|POLY-3 ADJUSTED (b)|     0.0%         5.2%         0.0%         7.0%        |4.8%         2.4%         0.0%         3.2%         |
|TERMINAL (d)       |     0/12 (0%)    1/14 (7%)    0/9 (0%)     0/6 (0%)    |2/26 (8%)    1/31 (3%)    0/15 (0%)    1/14 (7%)    |
|FIRST INCIDENCE    |     ---          712          ---          23          |730 (T)      730 (T)      ---          730 (T)      |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.162      P=0.291      (e)          P=0.196     |P=0.444N     P=0.438N     P=0.365N     P=0.712N     |
|POLY 3             |     P=0.243      P=0.260      (e)          P=0.193     |P=0.307N     P=0.497N     P=0.273N     P=0.594N     |
|POLY 1.5           |     P=0.243      P=0.251      (e)          P=0.199     |P=0.288N     P=0.501N     P=0.257N     P=0.574N     |
|POLY 6             |     P=0.240      P=0.271      (e)          P=0.189     |P=0.331N     P=0.487N     P=0.294N     P=0.613N     |
|LOGISTIC REGRESSION|     P=0.328      P=0.282      (e)          P=0.391     |P=0.444N     P=0.438N     (e)          P=0.712N     |
|COCH-ARM / FISHERS |     P=0.249      P=0.247      (e)          P=0.247     |P=0.253N     P=0.500N     P=0.247N     P=0.508N     |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      250 PPB      500 PPB      750 PPB     |CONTROL      250 PPB      500 PPB      750 PPB      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Lung: Alveolus                                                                                                                   |
|     Mineralization                                                                                                              |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     4/50 (8%)    3/50 (6%)    1/50 (2%)    4/50 (8%)   |0/50 (0%)    0/50 (0%)    0/50 (0%)    0/49 (0%)    |
|POLY-3 ADJUSTED (b)|     11.3%        7.5%         2.8%         13.8%       |0.0%         0.0%         0.0%         0.0%         |
|TERMINAL (d)       |     1/12 (8%)    0/14 (0%)    0/9 (0%)     0/6 (0%)    |0/26 (0%)    0/31 (0%)    0/15 (0%)    0/14 (0%)    |
|FIRST INCIDENCE    |     689          579          632          492         |---          ---          ---          ---          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.490      P=0.421N     P=0.235N     P=0.457     |(e)          (e)          (e)          (e)          |
|POLY 3             |     P=0.507N     P=0.435N     P=0.171N     P=0.533     |(e)          (e)          (e)          (e)          |
|POLY 1.5           |     P=0.496N     P=0.460N     P=0.172N     P=0.539     |(e)          (e)          (e)          (e)          |
|POLY 6             |     P=0.522N     P=0.400N     P=0.171N     P=0.538     |(e)          (e)          (e)          (e)          |
|LOGISTIC REGRESSION|     P=0.522N     P=0.454N     P=0.178N     P=0.519     |(e)          (e)          (e)          (e)          |
|COCH-ARM / FISHERS |     P=0.447N     P=0.500N     P=0.181N     P=0.643N    |(e)          (e)          (e)          (e)          |
|=================================================================================================================================|
       Date:  09/14/98                           EXPERIMENT: 05184 TEST: 05                                            Page 19
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                   GLUTARALDEHYDE
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      250 PPB      500 PPB      750 PPB     |CONTROL      250 PPB      500 PPB      750 PPB      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Lung: Interstitium                                                                                                               |
|     Fibrosis                                                                                                                    |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     8/50 (16%)   14/50 (28%)  17/50 (34%)  7/50 (14%)  |9/50 (18%)   13/50 (26%)  17/50 (34%)  24/49 (49%)  |
|POLY-3 ADJUSTED (b)|     22.0%        34.3%        41.8%        23.2%       |21.3%        30.3%        42.5%        70.4%        |
|TERMINAL (d)       |     4/12 (33%)   4/14 (29%)   0/9 (0%)     0/6 (0%)    |7/26 (27%)   9/31 (29%)   5/15 (33%)   11/14 (79%)  |
|FIRST INCIDENCE    |     583          579          481          468         |566          593          355          567          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.185      P=0.257      P=0.039 *    P=0.444     |P<0.001 **   P=0.374      P=0.005 **   P<0.001 **   |
|POLY 3             |     P=0.285      P=0.168      P=0.047 *    P=0.573     |P<0.001 **   P=0.239      P=0.029 *    P<0.001 **   |
|POLY 1.5           |     P=0.295      P=0.145      P=0.040 *    P=0.577     |P<0.001 **   P=0.229      P=0.037 *    P<0.001 **   |
|POLY 6             |     P=0.298      P=0.208      P=0.064      P=0.585     |P<0.001 **   P=0.266      P=0.023 *    P<0.001 **   |
|LOGISTIC REGRESSION|     P=0.329      P=0.183      P=0.034 *    P=0.563     |P<0.001 **   P=0.251      P=0.034 *    P<0.001 **   |
|COCH-ARM / FISHERS |     P=0.530      P=0.114      P=0.032 *    P=0.500N    |P<0.001 **   P=0.235      P=0.055      P<0.001 **   |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      250 PPB      500 PPB      750 PPB     |CONTROL      250 PPB      500 PPB      750 PPB      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Mammary Gland                                                                                                                    |
|     Galactocele                                                                                                                 |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     2/49 (4%)    1/50 (2%)    5/50 (10%)   0/50 (0%)   |2/50 (4%)    2/50 (4%)    0/50 (0%)    0/50 (0%)    |
|POLY-3 ADJUSTED (b)|     5.7%         2.6%         13.6%        0.0%        |4.8%         4.7%         0.0%         0.0%         |
|TERMINAL (d)       |     1/12 (8%)    1/14 (7%)    1/9 (11%)    0/6 (0%)    |1/26 (4%)    1/31 (3%)    0/15 (0%)    0/14 (0%)    |
|FIRST INCIDENCE    |     583          729 (T)      608          ---         |708          724          ---          ---          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.513      P=0.452N     P=0.197      P=0.340N    |P=0.126N     P=0.624N     P=0.345N     P=0.353N     |
|POLY 3             |     P=0.518      P=0.464N     P=0.233      P=0.293N    |P=0.090N     P=0.692N     P=0.273N     P=0.301N     |
|POLY 1.5           |     P=0.549      P=0.474N     P=0.232      P=0.283N    |P=0.078N     P=0.692      P=0.257N     P=0.285N     |
|POLY 6             |     P=0.486      P=0.453N     P=0.234      P=0.303N    |P=0.106N     P=0.683N     P=0.295N     P=0.318N     |
|LOGISTIC REGRESSION|     P=0.518N     P=0.457N     P=0.228      P=0.280N    |P=0.104N     P=0.665N     P=0.317N     P=0.326N     |
|COCH-ARM / FISHERS |     P=0.428N     P=0.492N     P=0.226      P=0.242N    |P=0.057N     P=0.691N     P=0.247N     P=0.247N     |
|=================================================================================================================================|
       Date:  09/14/98                           EXPERIMENT: 05184 TEST: 05                                            Page 20
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                   GLUTARALDEHYDE
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      250 PPB      500 PPB      750 PPB     |CONTROL      250 PPB      500 PPB      750 PPB      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Mammary Gland: Epithelium                                                                                                        |
|     Hyperplasia                                                                                                                 |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     0/49 (0%)    0/50 (0%)    0/50 (0%)    0/50 (0%)   |0/50 (0%)    0/50 (0%)    2/50 (4%)    0/50 (0%)    |
|POLY-3 ADJUSTED (b)|     0.0%         0.0%         0.0%         0.0%        |0.0%         0.0%         5.5%         0.0%         |
|TERMINAL (d)       |     0/12 (0%)    0/14 (0%)    0/9 (0%)     0/6 (0%)    |0/26 (0%)    0/31 (0%)    0/15 (0%)    0/14 (0%)    |
|FIRST INCIDENCE    |     ---          ---          ---          ---         |---          ---          589          ---          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     (e)          (e)          (e)          (e)         |P=0.305      (e)          P=0.194      (e)          |
|POLY 3             |     (e)          (e)          (e)          (e)         |P=0.288      (e)          P=0.208      (e)          |
|POLY 1.5           |     (e)          (e)          (e)          (e)         |P=0.305      (e)          P=0.220      (e)          |
|POLY 6             |     (e)          (e)          (e)          (e)         |P=0.275      (e)          P=0.195      (e)          |
|LOGISTIC REGRESSION|     (e)          (e)          (e)          (e)         |P=0.395      (e)          P=0.258      (e)          |
|COCH-ARM / FISHERS |     (e)          (e)          (e)          (e)         |P=0.375      (e)          P=0.247      (e)          |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      250 PPB      500 PPB      750 PPB     |CONTROL      250 PPB      500 PPB      750 PPB      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Mesentery: Fat                                                                                                                   |
|     Necrosis                                                                                                                    |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     8/10 (80%)   6/7 (86%)    5/6 (83%)    6/7 (86%)   |9/10 (90%)   9/9 (100%)   7/7 (100%)   3/3 (100%)   |
|POLY-3 ADJUSTED (b)|     82.8%        86.6%        83.3%        88.7%       |96.2%        100.0%       100.0%       100.0%       |
|TERMINAL (d)       |     3/3 (100%)   2/2 (100%)   0/1 (0%)     0/0 (0%)    |5/5 (100%)   6/6 (100%)   3/3 (100%)   2/2 (100%)   |
|FIRST INCIDENCE    |     583          550          533          449         |651          437          634          721          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.295      P=0.373N     P=0.453N     P=0.350     |P=0.412N     P=0.448N     P=0.414      P=0.379N     |
|POLY 3             |     P=0.486      P=0.684      P=0.744      P=0.650     |P=0.625      P=0.960      P=0.970      P=0.994      |
|POLY 1.5           |     P=0.479      P=0.655      P=0.712      P=0.637     |P=0.402      P=0.755      P=0.792      P=0.909      |
|POLY 6             |     P=0.504      P=0.740      P=0.737N     P=0.683     |P=0.998      P=1.000      P=1.000      P=1.000      |
|LOGISTIC REGRESSION|     P=0.355N     P=0.636      P=0.739N     P=0.640N    |P=0.285      P=0.349      (e)          (e)          |
|COCH-ARM / FISHERS |     P=0.472      P=0.640      P=0.786N     P=0.640     |P=0.268      P=0.526      P=0.588      P=0.769      |
|=================================================================================================================================|
       Date:  09/14/98                           EXPERIMENT: 05184 TEST: 05                                            Page 21
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                   GLUTARALDEHYDE
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      250 PPB      500 PPB      750 PPB     |CONTROL      250 PPB      500 PPB      750 PPB      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Nose                                                                                                                             |
|     Concretion                                                                                                                  |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     0/50 (0%)    0/50 (0%)    0/50 (0%)    0/50 (0%)   |2/50 (4%)    0/50 (0%)    0/50 (0%)    0/49 (0%)    |
|POLY-3 ADJUSTED (b)|     0.0%         0.0%         0.0%         0.0%        |4.7%         0.0%         0.0%         0.0%         |
|TERMINAL (d)       |     0/12 (0%)    0/14 (0%)    0/9 (0%)     0/6 (0%)    |0/26 (0%)    0/31 (0%)    0/15 (0%)    0/14 (0%)    |
|FIRST INCIDENCE    |     ---          ---          ---          ---         |518          ---          ---          ---          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     (e)          (e)          (e)          (e)         |P=0.075N     P=0.244N     P=0.274N     P=0.318N     |
|POLY 3             |     (e)          (e)          (e)          (e)         |P=0.069N     P=0.241N     P=0.279N     P=0.310N     |
|POLY 1.5           |     (e)          (e)          (e)          (e)         |P=0.064N     P=0.241N     P=0.261N     P=0.292N     |
|POLY 6             |     (e)          (e)          (e)          (e)         |P=0.076N     P=0.238N     P=0.305N     P=0.328N     |
|LOGISTIC REGRESSION|     (e)          (e)          (e)          (e)         |P=0.031N*    P=0.213N     P=0.202N     P=0.173N     |
|COCH-ARM / FISHERS |     (e)          (e)          (e)          (e)         |P=0.057N     P=0.247N     P=0.247N     P=0.253N     |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      250 PPB      500 PPB      750 PPB     |CONTROL      250 PPB      500 PPB      750 PPB      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Nose                                                                                                                             |
|     Foreign Body                                                                                                                |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     2/50 (4%)    2/50 (4%)    1/50 (2%)    0/50 (0%)   |5/50 (10%)   3/50 (6%)    2/50 (4%)    0/49 (0%)    |
|POLY-3 ADJUSTED (b)|     5.7%         5.1%         2.8%         0.0%        |11.9%        7.1%         5.6%         0.0%         |
|TERMINAL (d)       |     2/12 (17%)   0/14 (0%)    0/9 (0%)     0/6 (0%)    |3/26 (12%)   3/31 (10%)   2/15 (13%)   0/14 (0%)    |
|FIRST INCIDENCE    |     729 (T)      533          664          ---         |651          730 (T)      730 (T)      ---          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.190N     P=0.637N     P=0.562N     P=0.398N    |P=0.072N     P=0.286N     P=0.453N     P=0.099N     |
|POLY 3             |     P=0.165N     P=0.652N     P=0.493N     P=0.293N    |P=0.035N*    P=0.357N     P=0.287N     P=0.063N     |
|POLY 1.5           |     P=0.157N     P=0.668N     P=0.494N     P=0.286N    |P=0.028N*    P=0.361N     P=0.255N     P=0.054N     |
|POLY 6             |     P=0.174N     P=0.628N     P=0.493N     P=0.299N    |P=0.045N*    P=0.346N     P=0.333N     P=0.073N     |
|LOGISTIC REGRESSION|     P=0.140N     P=0.667N     P=0.513N     (e)         |P=0.043N*    P=0.333N     P=0.346N     P=0.065N     |
|COCH-ARM / FISHERS |     P=0.112N     P=0.691N     P=0.500N     P=0.247N    |P=0.015N*    P=0.357N     P=0.218N     P=0.030N*    |
|=================================================================================================================================|
       Date:  09/14/98                           EXPERIMENT: 05184 TEST: 05                                            Page 22
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                   GLUTARALDEHYDE
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      250 PPB      500 PPB      750 PPB     |CONTROL      250 PPB      500 PPB      750 PPB      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Nose: Goblet Cell, Respiratory Epithelium                                                                                        |
|     Hyperplasia                                                                                                                 |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     1/50 (2%)    0/50 (0%)    6/50 (12%)   6/50 (12%)  |1/50 (2%)    3/50 (6%)    5/50 (10%)   8/49 (16%)   |
|POLY-3 ADJUSTED (b)|     2.8%         0.0%         16.2%        20.0%       |2.4%         7.1%         13.4%        23.5%        |
|TERMINAL (d)       |     0/12 (0%)    0/14 (0%)    2/9 (22%)    1/6 (17%)   |0/26 (0%)    2/31 (7%)    1/15 (7%)    3/14 (21%)   |
|FIRST INCIDENCE    |     495          ---          593          393         |682          674          469          432          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P<0.001 **   P=0.496N     P=0.057      P=0.027 *   |P<0.001 **   P=0.347      P=0.047 *    P=0.004 **   |
|POLY 3             |     P=0.002 **   P=0.484N     P=0.058      P=0.029 *   |P=0.002 **   P=0.308      P=0.075      P=0.005 **   |
|POLY 1.5           |     P=0.002 **   P=0.490N     P=0.058      P=0.031 *   |P=0.002 **   P=0.304      P=0.086      P=0.007 **   |
|POLY 6             |     P<0.001 **   P=0.477N     P=0.059      P=0.029 *   |P<0.001 **   P=0.318      P=0.063      P=0.005 **   |
|LOGISTIC REGRESSION|     P=0.004 **   P=0.605N     P=0.058      P=0.052     |P=0.003 **   P=0.309      P=0.108      P=0.011 *    |
|COCH-ARM / FISHERS |     P=0.005 **   P=0.500N     P=0.056      P=0.056     |P=0.006 **   P=0.309      P=0.102      P=0.014 *    |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      250 PPB      500 PPB      750 PPB     |CONTROL      250 PPB      500 PPB      750 PPB      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Nose: Nasolacrimal Duct                                                                                                          |
|     Inflammation                                                                                                                |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     0/50 (0%)    3/50 (6%)    0/50 (0%)    0/50 (0%)   |4/50 (8%)    2/50 (4%)    2/50 (4%)    1/49 (2%)    |
|POLY-3 ADJUSTED (b)|     0.0%         7.6%         0.0%         0.0%        |9.3%         4.7%         5.6%         3.2%         |
|TERMINAL (d)       |     0/12 (0%)    0/14 (0%)    0/9 (0%)     0/6 (0%)    |1/26 (4%)    1/31 (3%)    1/15 (7%)    1/14 (7%)    |
|FIRST INCIDENCE    |     ---          617          ---          ---         |542          612          676          730 (T)      |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.371N     P=0.162      (e)          (e)         |P=0.256N     P=0.311N     P=0.490N     P=0.334N     |
|POLY 3             |     P=0.370N     P=0.141      (e)          (e)         |P=0.197N     P=0.344N     P=0.425N     P=0.287N     |
|POLY 1.5           |     P=0.362N     P=0.132      (e)          (e)         |P=0.170N     P=0.346N     P=0.386N     P=0.258N     |
|POLY 6             |     P=0.378N     P=0.154      (e)          (e)         |P=0.230N     P=0.338N     P=0.475N     P=0.318N     |
|LOGISTIC REGRESSION|     P=0.331N     P=0.121      (e)          (e)         |P=0.130N     P=0.326N     P=0.319N     P=0.190N     |
|COCH-ARM / FISHERS |     P=0.301N     P=0.121      (e)          (e)         |P=0.115N     P=0.339N     P=0.339N     P=0.187N     |
|=================================================================================================================================|
       Date:  09/14/98                           EXPERIMENT: 05184 TEST: 05                                            Page 23
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                   GLUTARALDEHYDE
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      250 PPB      500 PPB      750 PPB     |CONTROL      250 PPB      500 PPB      750 PPB      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Nose: Olfactory Epithelium                                                                                                       |
|     Atrophy                                                                                                                     |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     0/50 (0%)    0/50 (0%)    0/50 (0%)    4/50 (8%)   |0/50 (0%)    0/50 (0%)    0/50 (0%)    2/49 (4%)    |
|POLY-3 ADJUSTED (b)|     0.0%         0.0%         0.0%         12.7%       |0.0%         0.0%         0.0%         6.1%         |
|TERMINAL (d)       |     0/12 (0%)    0/14 (0%)    0/9 (0%)     0/6 (0%)    |0/26 (0%)    0/31 (0%)    0/15 (0%)    0/14 (0%)    |
|FIRST INCIDENCE    |     ---          ---          ---          100         |---          ---          ---          113          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.005 **   (e)          (e)          P=0.055     |P=0.043 *    (e)          (e)          P=0.196      |
|POLY 3             |     P=0.006 **   (e)          (e)          P=0.046 *   |P=0.054      (e)          (e)          P=0.188      |
|POLY 1.5           |     P=0.006 **   (e)          (e)          P=0.047 *   |P=0.055      (e)          (e)          P=0.198      |
|POLY 6             |     P=0.005 **   (e)          (e)          P=0.045 *   |P=0.050      (e)          (e)          P=0.180      |
|LOGISTIC REGRESSION|     P=0.326      (e)          (e)          P=0.609     |P=0.132      (e)          (e)          P=0.414      |
|COCH-ARM / FISHERS |     P=0.006 **   (e)          (e)          P=0.059     |P=0.055      (e)          (e)          P=0.242      |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      250 PPB      500 PPB      750 PPB     |CONTROL      250 PPB      500 PPB      750 PPB      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Nose: Olfactory Epithelium                                                                                                       |
|     Degeneration Hyaline                                                                                                        |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     4/50 (8%)    8/50 (16%)   9/50 (18%)   14/50 (28%) |4/50 (8%)    5/50 (10%)   12/50 (24%)  15/49 (31%)  |
|POLY-3 ADJUSTED (b)|     11.0%        19.3%        23.7%        44.0%       |9.6%         11.8%        30.6%        42.9%        |
|TERMINAL (d)       |     0/12 (0%)    1/14 (7%)    3/9 (33%)    2/6 (33%)   |3/26 (12%)   4/31 (13%)   2/15 (13%)   5/14 (36%)   |
|FIRST INCIDENCE    |     556          533          393          474         |708          675          533          432          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P<0.001 **   P=0.283      P=0.110      P=0.002 **  |P<0.001 **   P=0.598      P=0.005 **   P<0.001 **   |
|POLY 3             |     P<0.001 **   P=0.240      P=0.123      P<0.001 **  |P<0.001 **   P=0.508      P=0.015 *    P<0.001 **   |
|POLY 1.5           |     P=0.002 **   P=0.214      P=0.123      P=0.002 **  |P<0.001 **   P=0.499      P=0.019 *    P<0.001 **   |
|POLY 6             |     P<0.001 **   P=0.276      P=0.119      P=0.002 **  |P<0.001 **   P=0.527      P=0.013 *    P<0.001 **   |
|LOGISTIC REGRESSION|     P=0.002 **   P=0.150      P=0.117      P=0.003 **  |P<0.001 **   P=0.548      P=0.022 *    P<0.001 **   |
|COCH-ARM / FISHERS |     P=0.006 **   P=0.178      P=0.117      P=0.009 **  |P<0.001 **   P=0.500      P=0.027 *    P=0.004 **   |
|=================================================================================================================================|
       Date:  09/14/98                           EXPERIMENT: 05184 TEST: 05                                            Page 24
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                   GLUTARALDEHYDE
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      250 PPB      500 PPB      750 PPB     |CONTROL      250 PPB      500 PPB      750 PPB      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Nose: Respiratory Epithelium                                                                                                     |
|     Hyperplasia                                                                                                                 |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     6/50 (12%)   5/50 (10%)   17/50 (34%)  35/50 (70%) |1/50 (2%)    6/50 (12%)   15/50 (30%)  29/49 (59%)  |
|POLY-3 ADJUSTED (b)|     16.6%        12.6%        44.1%        86.1%       |2.4%         14.2%        37.3%        71.8%        |
|TERMINAL (d)       |     2/12 (17%)   1/14 (7%)    4/9 (44%)    6/6 (100%)  |1/26 (4%)    5/31 (16%)   2/15 (13%)   7/14 (50%)   |
|FIRST INCIDENCE    |     543          550          526          23          |730 (T)      675          355          113          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P<0.001 **   P=0.379N     P=0.008 **   P<0.001 **  |P<0.001 **   P=0.086      P<0.001 **   P<0.001 **   |
|POLY 3             |     P<0.001 **   P=0.434N     P=0.007 **   P<0.001 **  |P<0.001 **   P=0.057      P<0.001 **   P<0.001 **   |
|POLY 1.5           |     P<0.001 **   P=0.458N     P=0.007 **   P<0.001 **  |P<0.001 **   P=0.055      P<0.001 **   P<0.001 **   |
|POLY 6             |     P<0.001 **   P=0.404N     P=0.006 **   P<0.001 **  |P<0.001 **   P=0.062      P<0.001 **   P<0.001 **   |
|LOGISTIC REGRESSION|     P<0.001 **   P=0.449N     P=0.008 **   P<0.001 **  |P<0.001 **   P=0.069      P<0.001 **   P<0.001 **   |
|COCH-ARM / FISHERS |     P<0.001 **   P=0.500N     P=0.008 **   P<0.001 **  |P<0.001 **   P=0.056      P<0.001 **   P<0.001 **   |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      250 PPB      500 PPB      750 PPB     |CONTROL      250 PPB      500 PPB      750 PPB      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Nose: Respiratory Epithelium                                                                                                     |
|     Inflammation                                                                                                                |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     17/50 (34%)  10/50 (20%)  25/50 (50%)  43/50 (86%) |5/50 (10%)   9/50 (18%)   26/50 (52%)  42/49 (86%)  |
|POLY-3 ADJUSTED (b)|     44.9%        23.9%        61.4%        93.6%       |11.6%        21.3%        61.2%        92.2%        |
|TERMINAL (d)       |     8/12 (67%)   1/14 (7%)    6/9 (67%)    5/6 (83%)   |2/26 (8%)    8/31 (26%)   6/15 (40%)   11/14 (79%)  |
|FIRST INCIDENCE    |     543          449          481          23          |550          675          355          32           |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P<0.001 **   P=0.046N*    P=0.052      P<0.001 **  |P<0.001 **   P=0.272      P<0.001 **   P<0.001 **   |
|POLY 3             |     P<0.001 **   P=0.034N*    P=0.091      P<0.001 **  |P<0.001 **   P=0.179      P<0.001 **   P<0.001 **   |
|POLY 1.5           |     P<0.001 **   P=0.051N     P=0.086      P<0.001 **  |P<0.001 **   P=0.180      P<0.001 **   P<0.001 **   |
|POLY 6             |     P<0.001 **   P=0.020N*    P=0.106      P<0.001 **  |P<0.001 **   P=0.183      P<0.001 **   P<0.001 **   |
|LOGISTIC REGRESSION|     P<0.001 **   P=0.062N     P=0.075      P<0.001 **  |P<0.001 **   P=0.194      P<0.001 **   P<0.001 **   |
|COCH-ARM / FISHERS |     P<0.001 **   P=0.088N     P=0.078      P<0.001 **  |P<0.001 **   P=0.194      P<0.001 **   P<0.001 **   |
|=================================================================================================================================|
       Date:  09/14/98                           EXPERIMENT: 05184 TEST: 05                                            Page 25
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                   GLUTARALDEHYDE
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      250 PPB      500 PPB      750 PPB     |CONTROL      250 PPB      500 PPB      750 PPB      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Nose: Respiratory Epithelium                                                                                                     |
|     Metaplasia                                                                                                                  |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     1/50 (2%)    2/50 (4%)    11/50 (22%)  24/50 (48%) |1/50 (2%)    1/50 (2%)    11/50 (22%)  16/49 (33%)  |
|POLY-3 ADJUSTED (b)|     2.8%         5.1%         29.1%        65.1%       |2.4%         2.4%         28.4%        43.2%        |
|TERMINAL (d)       |     0/12 (0%)    0/14 (0%)    2/9 (22%)    5/6 (83%)   |0/26 (0%)    1/31 (3%)    1/15 (7%)    2/14 (14%)   |
|FIRST INCIDENCE    |     708          708          526          23          |550          730 (T)      533          113          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P<0.001 **   P=0.589      P=0.003 **   P<0.001 **  |P<0.001 **   P=0.741N     P<0.001 **   P<0.001 **   |
|POLY 3             |     P<0.001 **   P=0.535      P=0.002 **   P<0.001 **  |P<0.001 **   P=0.760      P<0.001 **   P<0.001 **   |
|POLY 1.5           |     P<0.001 **   P=0.522      P=0.002 **   P<0.001 **  |P<0.001 **   P=0.758      P<0.001 **   P<0.001 **   |
|POLY 6             |     P<0.001 **   P=0.553      P=0.002 **   P<0.001 **  |P<0.001 **   P=0.758N     P<0.001 **   P<0.001 **   |
|LOGISTIC REGRESSION|     P<0.001 **   P=0.568      P=0.003 **   P<0.001 **  |P<0.001 **   P=0.759N     P=0.003 **   P<0.001 **   |
|COCH-ARM / FISHERS |     P<0.001 **   P=0.500      P=0.002 **   P<0.001 **  |P<0.001 **   P=0.753N     P=0.002 **   P<0.001 **   |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      250 PPB      500 PPB      750 PPB     |CONTROL      250 PPB      500 PPB      750 PPB      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Nose: Squamous Epithelium                                                                                                        |
|     Hyperplasia                                                                                                                 |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     3/50 (6%)    11/50 (22%)  39/50 (78%)  48/50 (96%) |3/50 (6%)    15/50 (30%)  29/50 (58%)  45/49 (92%)  |
|POLY-3 ADJUSTED (b)|     8.5%         26.7%        86.4%        98.6%       |7.0%         33.8%        66.6%        94.6%        |
|TERMINAL (d)       |     1/12 (8%)    0/14 (0%)    8/9 (89%)    6/6 (100%)  |1/26 (4%)    7/31 (23%)   7/15 (47%)   12/14 (86%)  |
|FIRST INCIDENCE    |     702          533          365          23          |550          561          276          32           |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P<0.001 **   P=0.067      P<0.001 **   P<0.001 **  |P<0.001 **   P=0.008 **   P<0.001 **   P<0.001 **   |
|POLY 3             |     P<0.001 **   P=0.037 *    P<0.001 **   P<0.001 **  |P<0.001 **   P=0.002 **   P<0.001 **   P<0.001 **   |
|POLY 1.5           |     P<0.001 **   P=0.029 *    P<0.001 **   P<0.001 **  |P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 **   |
|POLY 6             |     P<0.001 **   P=0.053      P<0.001 **   P<0.001 **  |P<0.001 **   P=0.002 **   P<0.001 **   P<0.001 **   |
|LOGISTIC REGRESSION|     P<0.001 **   P=0.032 *    P<0.001 **   P<0.001 **  |P<0.001 **   P=0.002 **   P<0.001 **   P<0.001 **   |
|COCH-ARM / FISHERS |     P<0.001 **   P=0.020 *    P<0.001 **   P<0.001 **  |P<0.001 **   P=0.002 **   P<0.001 **   P<0.001 **   |
|=================================================================================================================================|
       Date:  09/14/98                           EXPERIMENT: 05184 TEST: 05                                            Page 26
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                   GLUTARALDEHYDE
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      250 PPB      500 PPB      750 PPB     |CONTROL      250 PPB      500 PPB      750 PPB      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Nose: Squamous Epithelium                                                                                                        |
|     Inflammation                                                                                                                |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     6/50 (12%)   17/50 (34%)  41/50 (82%)  49/50 (98%) |6/50 (12%)   26/50 (52%)  42/50 (84%)  48/49 (98%)  |
|POLY-3 ADJUSTED (b)|     16.7%        39.3%        89.1%        99.7%       |13.8%        56.0%        85.4%        99.3%        |
|TERMINAL (d)       |     2/12 (17%)   1/14 (7%)    7/9 (78%)    6/6 (100%)  |1/26 (4%)    14/31 (45%)  9/15 (60%)   14/14 (100%) |
|FIRST INCIDENCE    |     556          449          365          23          |550          542          276          32           |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P<0.001 **   P=0.047 *    P<0.001 **   P<0.001 **  |P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 **   |
|POLY 3             |     P<0.001 **   P=0.021 *    P<0.001 **   P<0.001 **  |P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 **   |
|POLY 1.5           |     P<0.001 **   P=0.014 *    P<0.001 **   P<0.001 **  |P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 **   |
|POLY 6             |     P<0.001 **   P=0.040 *    P<0.001 **   P<0.001 **  |P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 **   |
|LOGISTIC REGRESSION|     P<0.001 **   P=0.011 *    P<0.001 **   P<0.001 **  |P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 **   |
|COCH-ARM / FISHERS |     P<0.001 **   P=0.008 **   P<0.001 **   P<0.001 **  |P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 **   |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      250 PPB      500 PPB      750 PPB     |CONTROL      250 PPB      500 PPB      750 PPB      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Ovary                                                                                                                            |
|     Cyst                                                                                                                        |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |                                                        |3/50 (6%)    3/50 (6%)    7/50 (14%)   4/49 (8%)    |
|POLY-3 ADJUSTED (b)|                                                        |7.0%         7.0%         18.8%        12.3%        |
|TERMINAL (d)       |                                                        |0/26 (0%)    1/31 (3%)    3/15 (20%)   2/14 (14%)   |
|FIRST INCIDENCE    |                                                        |550          593          357          432          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |                                                        |P=0.070      P=0.642N     P=0.061      P=0.297      |
|POLY 3             |                                                        |P=0.116      P=0.663N     P=0.104      P=0.354      |
|POLY 1.5           |                                                        |P=0.143      P=0.658      P=0.126      P=0.385      |
|POLY 6             |                                                        |P=0.092      P=0.653N     P=0.080      P=0.323      |
|LOGISTIC REGRESSION|                                                        |P=0.207      P=0.657N     P=0.168      P=0.457      |
|COCH-ARM / FISHERS |                                                        |P=0.239      P=0.661N     P=0.159      P=0.489      |
|=================================================================================================================================|
       Date:  09/14/98                           EXPERIMENT: 05184 TEST: 05                                            Page 27
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                   GLUTARALDEHYDE
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      250 PPB      500 PPB      750 PPB     |CONTROL      250 PPB      500 PPB      750 PPB      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Pancreas: Acinus                                                                                                                 |
|     Atrophy                                                                                                                     |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     9/50 (18%)   3/49 (6%)    2/50 (4%)    5/48 (10%)  |3/50 (6%)    3/50 (6%)    3/50 (6%)    4/50 (8%)    |
|POLY-3 ADJUSTED (b)|     24.1%        7.8%         5.5%         17.6%       |7.2%         7.1%         8.2%         12.2%        |
|TERMINAL (d)       |     2/12 (17%)   3/14 (21%)   0/9 (0%)     2/6 (33%)   |2/26 (8%)    3/31 (10%)   0/15 (0%)    2/14 (14%)   |
|FIRST INCIDENCE    |     543          729 (T)      481          561         |708          730 (T)      619          583          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.273N     P=0.038N*    P=0.042N*    P=0.448N    |P=0.133      P=0.581N     P=0.469      P=0.247      |
|POLY 3             |     P=0.138N     P=0.047N*    P=0.024N*    P=0.371N    |P=0.284      P=0.660N     P=0.598      P=0.368      |
|POLY 1.5           |     P=0.131N     P=0.052N     P=0.024N*    P=0.345N    |P=0.315      P=0.660      P=0.626      P=0.397      |
|POLY 6             |     P=0.149N     P=0.044N*    P=0.028N*    P=0.401N    |P=0.254      P=0.648N     P=0.564      P=0.345      |
|LOGISTIC REGRESSION|     P=0.161N     P=0.043N*    P=0.027N*    P=0.340N    |P=0.243      P=0.607N     P=0.580      P=0.350      |
|COCH-ARM / FISHERS |     P=0.106N     P=0.065N     P=0.026N*    P=0.217N    |P=0.399      P=0.661N     P=0.661N     P=0.500      |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      250 PPB      500 PPB      750 PPB     |CONTROL      250 PPB      500 PPB      750 PPB      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Parathyroid Gland                                                                                                                |
|     Hyperplasia                                                                                                                 |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     7/42 (17%)   7/38 (18%)   1/45 (2%)    3/41 (7%)   |0/42 (0%)    0/39 (0%)    2/44 (5%)    0/36 (0%)    |
|POLY-3 ADJUSTED (b)|     22.6%        22.7%        3.1%         11.9%       |0.0%         0.0%         6.2%         0.0%         |
|TERMINAL (d)       |     1/10 (10%)   1/11 (9%)    0/6 (0%)     0/5 (0%)    |0/23 (0%)    0/25 (0%)    1/13 (8%)    0/10 (0%)    |
|FIRST INCIDENCE    |     657          356          661          561         |---          ---          543          ---          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.101N     P=0.490N     P=0.058N     P=0.336N    |P=0.256      (e)          P=0.168      (e)          |
|POLY 3             |     P=0.036N*    P=0.619      P=0.022N*    P=0.240N    |P=0.277      (e)          P=0.214      (e)          |
|POLY 1.5           |     P=0.033N*    P=0.588      P=0.021N*    P=0.225N    |P=0.292      (e)          P=0.228      (e)          |
|POLY 6             |     P=0.043N*    P=0.581N     P=0.024N*    P=0.258N    |P=0.264      (e)          P=0.197      (e)          |
|LOGISTIC REGRESSION|     P=0.039N*    P=0.566      P=0.028N*    P=0.268N    |P=0.357      (e)          P=0.258      (e)          |
|COCH-ARM / FISHERS |     P=0.026N*    P=0.534      P=0.023N*    P=0.166N    |P=0.354      (e)          P=0.259      (e)          |
|=================================================================================================================================|
       Date:  09/14/98                           EXPERIMENT: 05184 TEST: 05                                            Page 28
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                   GLUTARALDEHYDE
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      250 PPB      500 PPB      750 PPB     |CONTROL      250 PPB      500 PPB      750 PPB      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Pituitary Gland                                                                                                                  |
|     Cyst                                                                                                                        |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     2/50 (4%)    2/49 (4%)    1/50 (2%)    1/50 (2%)   |3/50 (6%)    1/50 (2%)    3/50 (6%)    2/49 (4%)    |
|POLY-3 ADJUSTED (b)|     5.6%         5.2%         2.8%         3.6%        |7.1%         2.4%         8.1%         6.2%         |
|TERMINAL (d)       |     0/12 (0%)    1/14 (7%)    0/9 (0%)     0/6 (0%)    |1/26 (4%)    1/31 (3%)    0/15 (0%)    0/14 (0%)    |
|FIRST INCIDENCE    |     495          671          652          708         |550          730 (T)      558          628          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.413N     P=0.643N     P=0.515N     P=0.593N    |P=0.415      P=0.277N     P=0.509      P=0.668N     |
|POLY 3             |     P=0.367N     P=0.670N     P=0.501N     P=0.590N    |P=0.510      P=0.308N     P=0.595      P=0.624N     |
|POLY 1.5           |     P=0.353N     P=0.682N     P=0.498N     P=0.576N    |P=0.536      P=0.310N     P=0.624      P=0.598N     |
|POLY 6             |     P=0.383N     P=0.655N     P=0.507N     P=0.604N    |P=0.484      P=0.302N     P=0.561      P=0.647N     |
|LOGISTIC REGRESSION|     P=0.340N     P=0.690      P=0.509N     P=0.553N    |P=0.540N     P=0.305N     P=0.641N     P=0.562N     |
|COCH-ARM / FISHERS |     P=0.288N     P=0.684      P=0.500N     P=0.500N    |P=0.508N     P=0.309N     P=0.661N     P=0.510N     |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      250 PPB      500 PPB      750 PPB     |CONTROL      250 PPB      500 PPB      750 PPB      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Pituitary Gland                                                                                                                  |
|     Hemorrhage                                                                                                                  |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     1/50 (2%)    0/49 (0%)    3/50 (6%)    3/50 (6%)   |1/50 (2%)    0/50 (0%)    1/50 (2%)    1/49 (2%)    |
|POLY-3 ADJUSTED (b)|     2.9%         0.0%         8.3%         10.6%       |2.4%         0.0%         2.7%         3.1%         |
|TERMINAL (d)       |     1/12 (8%)    0/14 (0%)    1/9 (11%)    0/6 (0%)    |0/26 (0%)    0/31 (0%)    0/15 (0%)    0/14 (0%)    |
|FIRST INCIDENCE    |     729 (T)      ---          587          492         |566          ---          513          514          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.031 *    P=0.469N     P=0.246      P=0.185     |P=0.428      P=0.504N     P=0.729      P=0.697      |
|POLY 3             |     P=0.058      P=0.483N     P=0.315      P=0.231     |P=0.458      P=0.501N     P=0.727      P=0.698      |
|POLY 1.5           |     P=0.062      P=0.491N     P=0.313      P=0.239     |P=0.468      P=0.502N     P=0.742      P=0.711      |
|POLY 6             |     P=0.054      P=0.472N     P=0.316      P=0.228     |P=0.447      P=0.497N     P=0.707      P=0.685      |
|LOGISTIC REGRESSION|     P=0.051      (e)          P=0.305      P=0.226     |P=0.595N     P=0.484N     P=0.731N     P=0.718N     |
|COCH-ARM / FISHERS |     P=0.086      P=0.505N     P=0.309      P=0.309     |P=0.495      P=0.500N     P=0.753N     P=0.747      |
|=================================================================================================================================|
       Date:  09/14/98                           EXPERIMENT: 05184 TEST: 05                                            Page 29
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                   GLUTARALDEHYDE
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      250 PPB      500 PPB      750 PPB     |CONTROL      250 PPB      500 PPB      750 PPB      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Pituitary Gland: Pars Distalis                                                                                                   |
|     Hyperplasia                                                                                                                 |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     6/50 (12%)   5/49 (10%)   4/50 (8%)    1/50 (2%)   |3/50 (6%)    4/50 (8%)    4/50 (8%)    7/49 (14%)   |
|POLY-3 ADJUSTED (b)|     16.6%        12.8%        11.0%        3.6%        |7.1%         9.5%         11.0%        21.5%        |
|TERMINAL (d)       |     3/12 (25%)   1/14 (7%)    1/9 (11%)    0/6 (0%)    |1/26 (4%)    3/31 (10%)   2/15 (13%)   2/14 (14%)   |
|FIRST INCIDENCE    |     555          634          533          718         |598          720          617          628          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.127N     P=0.387N     P=0.441N     P=0.167N    |P=0.014 *    P=0.573      P=0.299      P=0.044 *    |
|POLY 3             |     P=0.091N     P=0.446N     P=0.362N     P=0.109N    |P=0.051      P=0.497      P=0.417      P=0.071      |
|POLY 1.5           |     P=0.079N     P=0.472N     P=0.360N     P=0.099N    |P=0.064      P=0.494      P=0.452      P=0.085      |
|POLY 6             |     P=0.104N     P=0.412N     P=0.369N     P=0.120N    |P=0.039 *    P=0.506      P=0.373      P=0.060      |
|LOGISTIC REGRESSION|     P=0.071N     P=0.440N     P=0.361N     P=0.105N    |P=0.037 *    P=0.506      P=0.443      P=0.073      |
|COCH-ARM / FISHERS |     P=0.040N*    P=0.514N     P=0.370N     P=0.056N    |P=0.106      P=0.500      P=0.500      P=0.151      |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      250 PPB      500 PPB      750 PPB     |CONTROL      250 PPB      500 PPB      750 PPB      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Preputial Gland                                                                                                                  |
|     Hyperplasia                                                                                                                 |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     0/50 (0%)    1/50 (2%)    2/50 (4%)    0/50 (0%)   |                                                    |
|POLY-3 ADJUSTED (b)|     0.0%         2.6%         5.5%         0.0%        |                                                    |
|TERMINAL (d)       |     0/12 (0%)    0/14 (0%)    0/9 (0%)     0/6 (0%)    |                                                    |
|FIRST INCIDENCE    |     ---          634          593          ---         |                                                    |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.431      P=0.531      P=0.246      (e)         |                                                    |
|POLY 3             |     P=0.391      P=0.522      P=0.243      (e)         |                                                    |
|POLY 1.5           |     P=0.406      P=0.513      P=0.242      (e)         |                                                    |
|POLY 6             |     P=0.378      P=0.533      P=0.245      (e)         |                                                    |
|LOGISTIC REGRESSION|     P=0.480      P=0.493      P=0.236      (e)         |                                                    |
|COCH-ARM / FISHERS |     P=0.500      P=0.500      P=0.247      (e)         |                                                    |
|=================================================================================================================================|
       Date:  09/14/98                           EXPERIMENT: 05184 TEST: 05                                            Page 30
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                   GLUTARALDEHYDE
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      250 PPB      500 PPB      750 PPB     |CONTROL      250 PPB      500 PPB      750 PPB      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Preputial Gland                                                                                                                  |
|     Inflammation                                                                                                                |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     5/50 (10%)   2/50 (4%)    3/50 (6%)    1/50 (2%)   |                                                    |
|POLY-3 ADJUSTED (b)|     13.8%        5.2%         8.2%         3.6%        |                                                    |
|TERMINAL (d)       |     1/12 (8%)    1/14 (7%)    0/9 (0%)     0/6 (0%)    |                                                    |
|FIRST INCIDENCE    |     543          724          593          708         |                                                    |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.183N     P=0.168N     P=0.407N     P=0.203N    |                                                    |
|POLY 3             |     P=0.142N     P=0.186N     P=0.351N     P=0.173N    |                                                    |
|POLY 1.5           |     P=0.131N     P=0.196N     P=0.350N     P=0.160N    |                                                    |
|POLY 6             |     P=0.154N     P=0.175N     P=0.356N     P=0.188N    |                                                    |
|LOGISTIC REGRESSION|     P=0.124N     P=0.175N     P=0.350N     P=0.162N    |                                                    |
|COCH-ARM / FISHERS |     P=0.083N     P=0.218N     P=0.357N     P=0.102N    |                                                    |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      250 PPB      500 PPB      750 PPB     |CONTROL      250 PPB      500 PPB      750 PPB      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Prostate                                                                                                                         |
|     Hyperplasia                                                                                                                 |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     0/50 (0%)    1/50 (2%)    2/50 (4%)    0/50 (0%)   |                                                    |
|POLY-3 ADJUSTED (b)|     0.0%         2.6%         5.6%         0.0%        |                                                    |
|TERMINAL (d)       |     0/12 (0%)    1/14 (7%)    1/9 (11%)    0/6 (0%)    |                                                    |
|FIRST INCIDENCE    |     ---          729 (T)      711          ---         |                                                    |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.348      P=0.531      P=0.201      (e)         |                                                    |
|POLY 3             |     P=0.390      P=0.520      P=0.239      (e)         |                                                    |
|POLY 1.5           |     P=0.405      P=0.512      P=0.240      (e)         |                                                    |
|POLY 6             |     P=0.377      P=0.530      P=0.237      (e)         |                                                    |
|LOGISTIC REGRESSION|     P=0.386      P=0.531      P=0.211      (e)         |                                                    |
|COCH-ARM / FISHERS |     P=0.500      P=0.500      P=0.247      (e)         |                                                    |
|=================================================================================================================================|
       Date:  09/14/98                           EXPERIMENT: 05184 TEST: 05                                            Page 31
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                   GLUTARALDEHYDE
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      250 PPB      500 PPB      750 PPB     |CONTROL      250 PPB      500 PPB      750 PPB      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Prostate                                                                                                                         |
|     Inflammation                                                                                                                |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     9/50 (18%)   4/50 (8%)    5/50 (10%)   3/50 (6%)   |                                                    |
|POLY-3 ADJUSTED (b)|     24.7%        10.0%        13.7%        10.4%       |                                                    |
|TERMINAL (d)       |     5/12 (42%)   0/14 (0%)    1/9 (11%)    0/6 (0%)    |                                                    |
|FIRST INCIDENCE    |     543          495          561          107         |                                                    |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.178N     P=0.076N     P=0.301N     P=0.236N    |                                                    |
|POLY 3             |     P=0.094N     P=0.075N     P=0.178N     P=0.120N    |                                                    |
|POLY 1.5           |     P=0.086N     P=0.090N     P=0.181N     P=0.111N    |                                                    |
|POLY 6             |     P=0.102N     P=0.058N     P=0.175N     P=0.125N    |                                                    |
|LOGISTIC REGRESSION|     P=0.066N     P=0.094N     P=0.184N     P=0.103N    |                                                    |
|COCH-ARM / FISHERS |     P=0.049N*    P=0.117N     P=0.194N     P=0.061N    |                                                    |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      250 PPB      500 PPB      750 PPB     |CONTROL      250 PPB      500 PPB      750 PPB      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Seminal Vesicle                                                                                                                  |
|     Inflammation                                                                                                                |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     3/50 (6%)    1/50 (2%)    0/50 (0%)    0/49 (0%)   |                                                    |
|POLY-3 ADJUSTED (b)|     8.5%         2.6%         0.0%         0.0%        |                                                    |
|TERMINAL (d)       |     2/12 (17%)   0/14 (0%)    0/9 (0%)     0/6 (0%)    |                                                    |
|FIRST INCIDENCE    |     694          716          ---          ---         |                                                    |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.041N*    P=0.250N     P=0.171N     P=0.238N    |                                                    |
|POLY 3             |     P=0.027N*    P=0.270N     P=0.115N     P=0.171N    |                                                    |
|POLY 1.5           |     P=0.026N*    P=0.283N     P=0.115N     P=0.165N    |                                                    |
|POLY 6             |     P=0.028N*    P=0.253N     P=0.115N     P=0.175N    |                                                    |
|LOGISTIC REGRESSION|     P=0.029N*    P=0.231N     P=0.130N     P=0.180N    |                                                    |
|COCH-ARM / FISHERS |     P=0.022N*    P=0.309N     P=0.121N     P=0.125N    |                                                    |
|=================================================================================================================================|
       Date:  09/14/98                           EXPERIMENT: 05184 TEST: 05                                            Page 32
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                   GLUTARALDEHYDE
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      250 PPB      500 PPB      750 PPB     |CONTROL      250 PPB      500 PPB      750 PPB      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Skin                                                                                                                             |
|     Cyst Epithelial Inclusion                                                                                                   |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     2/50 (4%)    2/50 (4%)    0/50 (0%)    0/50 (0%)   |1/50 (2%)    3/50 (6%)    0/50 (0%)    0/50 (0%)    |
|POLY-3 ADJUSTED (b)|     5.6%         5.1%         0.0%         0.0%        |2.4%         7.0%         0.0%         0.0%         |
|TERMINAL (d)       |     1/12 (8%)    1/14 (7%)    0/9 (0%)     0/6 (0%)    |0/26 (0%)    1/31 (3%)    0/15 (0%)    0/14 (0%)    |
|FIRST INCIDENCE    |     617          634          ---          ---         |682          615          ---          ---          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.092N     P=0.630N     P=0.260N     P=0.342N    |P=0.219N     P=0.337      P=0.590N     P=0.581N     |
|POLY 3             |     P=0.077N     P=0.660N     P=0.235N     P=0.296N    |P=0.205N     P=0.311      P=0.532N     P=0.553N     |
|POLY 1.5           |     P=0.073N     P=0.672N     P=0.234N     P=0.287N    |P=0.179N     P=0.305      P=0.518N     P=0.540N     |
|POLY 6             |     P=0.082N     P=0.643N     P=0.239N     P=0.305N    |P=0.238N     P=0.323      P=0.549N     P=0.566N     |
|LOGISTIC REGRESSION|     P=0.071N     P=0.660N     P=0.235N     P=0.292N    |P=0.158N     P=0.304      P=0.523N     P=0.545N     |
|COCH-ARM / FISHERS |     P=0.057N     P=0.691N     P=0.247N     P=0.247N    |P=0.129N     P=0.309      P=0.500N     P=0.500N     |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      250 PPB      500 PPB      750 PPB     |CONTROL      250 PPB      500 PPB      750 PPB      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Skin                                                                                                                             |
|     Hyperkeratosis                                                                                                              |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     0/50 (0%)    0/50 (0%)    0/50 (0%)    1/50 (2%)   |2/50 (4%)    0/50 (0%)    0/50 (0%)    0/50 (0%)    |
|POLY-3 ADJUSTED (b)|     0.0%         0.0%         0.0%         3.6%        |4.8%         0.0%         0.0%         0.0%         |
|TERMINAL (d)       |     0/12 (0%)    0/14 (0%)    0/9 (0%)     0/6 (0%)    |1/26 (4%)    0/31 (0%)    0/15 (0%)    0/14 (0%)    |
|FIRST INCIDENCE    |     ---          ---          ---          683         |674          ---          ---          ---          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.142      (e)          (e)          P=0.436     |P=0.092N     P=0.218N     P=0.340N     P=0.357N     |
|POLY 3             |     P=0.215      (e)          (e)          P=0.454     |P=0.068N     P=0.236N     P=0.274N     P=0.302N     |
|POLY 1.5           |     P=0.210      (e)          (e)          P=0.459     |P=0.063N     P=0.238N     P=0.258N     P=0.285N     |
|POLY 6             |     P=0.216      (e)          (e)          P=0.450     |P=0.074N     P=0.231N     P=0.296N     P=0.319N     |
|LOGISTIC REGRESSION|     P=0.150      (e)          (e)          P=0.447     |P=0.073N     P=0.235N     P=0.286N     P=0.306N     |
|COCH-ARM / FISHERS |     P=0.185      (e)          (e)          P=0.500     |P=0.056N     P=0.247N     P=0.247N     P=0.247N     |
|=================================================================================================================================|
       Date:  09/14/98                           EXPERIMENT: 05184 TEST: 05                                            Page 33
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                   GLUTARALDEHYDE
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      250 PPB      500 PPB      750 PPB     |CONTROL      250 PPB      500 PPB      750 PPB      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Spinal Cord                                                                                                                      |
|     Demyelination                                                                                                               |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     0/0 (0%)     0/0 (0%)     0/0 (0%)     0/0 (0%)    |0/1 (0%)     2/2 (100%)   0/0 (0%)     2/4 (50%)    |
|POLY-3 ADJUSTED (b)|     0.0%         0.0%         0.0%         0.0%        |0.0%         100.0%       0.0%         99.7%        |
|TERMINAL (d)       |     0/0 (0%)     0/0 (0%)     0/0 (0%)     0/0 (0%)    |0/0 (0%)     0/0 (0%)     0/0 (0%)     0/0 (0%)     |
|FIRST INCIDENCE    |     ---          ---          ---          ---         |---          117          ---          108          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     (e)          (e)          (e)          (e)         |P=0.139      P=0.500      (e)          P=0.229      |
|POLY 3             |     (e)          (e)          (e)          (e)         |(e)          P=1.000N     (e)          P=1.000      |
|POLY 1.5           |     (e)          (e)          (e)          (e)         |(e)          P=1.000N     (e)          P=1.000      |
|POLY 6             |     (e)          (e)          (e)          (e)         |(e)          P=1.000N     (e)          P=1.000      |
|LOGISTIC REGRESSION|     (e)          (e)          (e)          (e)         |P=0.476      P=0.496      (e)          P=0.863      |
|COCH-ARM / FISHERS |     (e)          (e)          (e)          (e)         |P=0.625N     P=0.333      (e)          P=0.600      |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      250 PPB      500 PPB      750 PPB     |CONTROL      250 PPB      500 PPB      750 PPB      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Spleen                                                                                                                           |
|     Fibrosis                                                                                                                    |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     15/50 (30%)  15/50 (30%)  16/50 (32%)  9/50 (18%)  |5/50 (10%)   7/50 (14%)   8/50 (16%)   4/50 (8%)    |
|POLY-3 ADJUSTED (b)|     39.4%        36.1%        41.2%        31.5%       |11.9%        16.5%        20.8%        12.0%        |
|TERMINAL (d)       |     6/12 (50%)   6/14 (43%)   3/9 (33%)    3/6 (50%)   |3/26 (12%)   4/31 (13%)   1/15 (7%)    2/14 (14%)   |
|FIRST INCIDENCE    |     543          449          561          561         |708          617          513          113          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.475      P=0.378N     P=0.399      P=0.494N    |P=0.229      P=0.501      P=0.115      P=0.495      |
|POLY 3             |     P=0.403N     P=0.469N     P=0.530      P=0.340N    |P=0.407      P=0.389      P=0.218      P=0.634      |
|POLY 1.5           |     P=0.341N     P=0.510N     P=0.525      P=0.288N    |P=0.462      P=0.379      P=0.241      P=0.607N     |
|POLY 6             |     P=0.474N     P=0.429N     P=0.538      P=0.408N    |P=0.354      P=0.412      P=0.194      P=0.604      |
|LOGISTIC REGRESSION|     P=0.336N     P=0.484N     P=0.519      P=0.313N    |P=0.535N     P=0.410      P=0.256      P=0.551N     |
|COCH-ARM / FISHERS |     P=0.129N     P=0.586N     P=0.500      P=0.121N    |P=0.461N     P=0.380      P=0.277      P=0.500N     |
|=================================================================================================================================|
       Date:  09/14/98                           EXPERIMENT: 05184 TEST: 05                                            Page 34
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                   GLUTARALDEHYDE
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      250 PPB      500 PPB      750 PPB     |CONTROL      250 PPB      500 PPB      750 PPB      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Spleen                                                                                                                           |
|     Hematopoietic Cell Proliferation                                                                                            |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     0/50 (0%)    1/50 (2%)    0/50 (0%)    0/50 (0%)   |2/50 (4%)    1/50 (2%)    1/50 (2%)    0/50 (0%)    |
|POLY-3 ADJUSTED (b)|     0.0%         2.6%         0.0%         0.0%        |4.7%         2.4%         2.7%         0.0%         |
|TERMINAL (d)       |     0/12 (0%)    0/14 (0%)    0/9 (0%)     0/6 (0%)    |1/26 (4%)    1/31 (3%)    0/15 (0%)    0/14 (0%)    |
|FIRST INCIDENCE    |     ---          617          ---          ---         |518          730 (T)      276          ---          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.534N     P=0.546      (e)          (e)         |P=0.210N     P=0.464N     P=0.575N     P=0.349N     |
|POLY 3             |     P=0.563N     P=0.522      (e)          (e)         |P=0.193N     P=0.502N     P=0.550N     P=0.305N     |
|POLY 1.5           |     P=0.555N     P=0.513      (e)          (e)         |P=0.174N     P=0.504N     P=0.527N     P=0.287N     |
|POLY 6             |     P=0.571N     P=0.533      (e)          (e)         |P=0.216N     P=0.495N     P=0.579N     P=0.323N     |
|LOGISTIC REGRESSION|     P=0.502N     P=0.482      (e)          (e)         |P=0.074N     P=0.498N     P=0.434N     P=0.227N     |
|COCH-ARM / FISHERS |     P=0.500N     P=0.500      (e)          (e)         |P=0.129N     P=0.500N     P=0.500N     P=0.247N     |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      250 PPB      500 PPB      750 PPB     |CONTROL      250 PPB      500 PPB      750 PPB      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Spleen                                                                                                                           |
|     Hemorrhage                                                                                                                  |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     0/50 (0%)    1/50 (2%)    1/50 (2%)    0/50 (0%)   |1/50 (2%)    0/50 (0%)    2/50 (4%)    1/50 (2%)    |
|POLY-3 ADJUSTED (b)|     0.0%         2.5%         2.8%         0.0%        |2.4%         0.0%         5.5%         3.1%         |
|TERMINAL (d)       |     0/12 (0%)    0/14 (0%)    0/9 (0%)     0/6 (0%)    |0/26 (0%)    0/31 (0%)    0/15 (0%)    0/14 (0%)    |
|FIRST INCIDENCE    |     ---          569          654          ---         |660          ---          355          514          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.579      P=0.529      P=0.523      (e)         |P=0.313      P=0.500N     P=0.419      P=0.676      |
|POLY 3             |     P=0.557      P=0.522      P=0.504      (e)         |P=0.343      P=0.499N     P=0.453      P=0.701      |
|POLY 1.5           |     P=0.565      P=0.514      P=0.504      (e)         |P=0.359      P=0.501N     P=0.474      P=0.716      |
|POLY 6             |     P=0.550      P=0.534      P=0.504      (e)         |P=0.329      P=0.495N     P=0.425      P=0.687      |
|LOGISTIC REGRESSION|     P=0.626N     P=0.450      P=0.502      (e)         |P=0.514      P=0.499N     P=0.552      P=0.747N     |
|COCH-ARM / FISHERS |     P=0.625      P=0.500      P=0.500      (e)         |P=0.411      P=0.500N     P=0.500      P=0.753N     |
|=================================================================================================================================|
       Date:  09/14/98                           EXPERIMENT: 05184 TEST: 05                                            Page 35
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                   GLUTARALDEHYDE
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      250 PPB      500 PPB      750 PPB     |CONTROL      250 PPB      500 PPB      750 PPB      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Spleen                                                                                                                           |
|     Infarct                                                                                                                     |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     0/50 (0%)    3/50 (6%)    0/50 (0%)    0/50 (0%)   |0/50 (0%)    0/50 (0%)    0/50 (0%)    0/50 (0%)    |
|POLY-3 ADJUSTED (b)|     0.0%         7.6%         0.0%         0.0%        |0.0%         0.0%         0.0%         0.0%         |
|TERMINAL (d)       |     0/12 (0%)    0/14 (0%)    0/9 (0%)     0/6 (0%)    |0/26 (0%)    0/31 (0%)    0/15 (0%)    0/14 (0%)    |
|FIRST INCIDENCE    |     ---          634          ---          ---         |---          ---          ---          ---          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.364N     P=0.164      (e)          (e)         |(e)          (e)          (e)          (e)          |
|POLY 3             |     P=0.371N     P=0.139      (e)          (e)         |(e)          (e)          (e)          (e)          |
|POLY 1.5           |     P=0.362N     P=0.131      (e)          (e)         |(e)          (e)          (e)          (e)          |
|POLY 6             |     P=0.378N     P=0.152      (e)          (e)         |(e)          (e)          (e)          (e)          |
|LOGISTIC REGRESSION|     P=0.347N     P=0.134      (e)          (e)         |(e)          (e)          (e)          (e)          |
|COCH-ARM / FISHERS |     P=0.301N     P=0.121      (e)          (e)         |(e)          (e)          (e)          (e)          |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      250 PPB      500 PPB      750 PPB     |CONTROL      250 PPB      500 PPB      750 PPB      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Stomach, Forestomach                                                                                                             |
|     Inflammation                                                                                                                |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     8/49 (16%)   3/49 (6%)    3/50 (6%)    5/48 (10%)  |3/49 (6%)    4/50 (8%)    2/50 (4%)    4/50 (8%)    |
|POLY-3 ADJUSTED (b)|     21.5%        7.6%         8.2%         16.5%       |7.2%         9.1%         5.5%         11.7%        |
|TERMINAL (d)       |     2/12 (17%)   0/14 (0%)    0/9 (0%)     0/6 (0%)    |0/26 (0%)    0/31 (0%)    0/15 (0%)    0/14 (0%)    |
|FIRST INCIDENCE    |     580          550          593          106         |651          542          543          375          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.360N     P=0.067N     P=0.121N     P=0.493N    |P=0.315      P=0.516      P=0.642N     P=0.349      |
|POLY 3             |     P=0.262N     P=0.075N     P=0.097N     P=0.417N    |P=0.391      P=0.529      P=0.560N     P=0.394      |
|POLY 1.5           |     P=0.245N     P=0.082N     P=0.093N     P=0.388N    |P=0.427      P=0.517      P=0.530N     P=0.418      |
|POLY 6             |     P=0.284N     P=0.069N     P=0.108N     P=0.452N    |P=0.349      P=0.549      P=0.599N     P=0.369      |
|LOGISTIC REGRESSION|     P=0.121N     P=0.107N     P=0.094N     P=0.229N    |P=0.513N     P=0.521      P=0.499N     P=0.560      |
|COCH-ARM / FISHERS |     P=0.199N     P=0.100N     P=0.094N     P=0.290N    |P=0.510      P=0.511      P=0.490N     P=0.511      |
|=================================================================================================================================|
       Date:  09/14/98                           EXPERIMENT: 05184 TEST: 05                                            Page 36
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                   GLUTARALDEHYDE
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      250 PPB      500 PPB      750 PPB     |CONTROL      250 PPB      500 PPB      750 PPB      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Stomach, Forestomach                                                                                                             |
|     Mineralization                                                                                                              |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     4/49 (8%)    1/49 (2%)    1/50 (2%)    0/48 (0%)   |0/49 (0%)    0/50 (0%)    0/50 (0%)    0/50 (0%)    |
|POLY-3 ADJUSTED (b)|     11.4%        2.6%         2.8%         0.0%        |0.0%         0.0%         0.0%         0.0%         |
|TERMINAL (d)       |     0/12 (0%)    0/14 (0%)    0/9 (0%)     0/6 (0%)    |0/26 (0%)    0/31 (0%)    0/15 (0%)    0/14 (0%)    |
|FIRST INCIDENCE    |     689          579          632          ---         |---          ---          ---          ---          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.036N*    P=0.138N     P=0.225N     P=0.112N    |(e)          (e)          (e)          (e)          |
|POLY 3             |     P=0.031N*    P=0.146N     P=0.169N     P=0.095N    |(e)          (e)          (e)          (e)          |
|POLY 1.5           |     P=0.029N*    P=0.158N     P=0.169N     P=0.090N    |(e)          (e)          (e)          (e)          |
|POLY 6             |     P=0.034N*    P=0.133N     P=0.172N     P=0.102N    |(e)          (e)          (e)          (e)          |
|LOGISTIC REGRESSION|     P=0.027N*    P=0.148N     P=0.176N     P=0.102N    |(e)          (e)          (e)          (e)          |
|COCH-ARM / FISHERS |     P=0.021N*    P=0.181N     P=0.175N     P=0.061N    |(e)          (e)          (e)          (e)          |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      250 PPB      500 PPB      750 PPB     |CONTROL      250 PPB      500 PPB      750 PPB      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Stomach, Forestomach                                                                                                             |
|     Ulcer                                                                                                                       |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     5/49 (10%)   7/49 (14%)   4/50 (8%)    2/48 (4%)   |3/49 (6%)    2/50 (4%)    2/50 (4%)    2/50 (4%)    |
|POLY-3 ADJUSTED (b)|     13.9%        17.5%        11.0%        7.0%        |7.2%         4.7%         5.6%         5.9%         |
|TERMINAL (d)       |     1/12 (8%)    1/14 (7%)    0/9 (0%)     0/6 (0%)    |0/26 (0%)    1/31 (3%)    0/15 (0%)    0/14 (0%)    |
|FIRST INCIDENCE    |     602          550          581          106         |598          720          703          113          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.248N     P=0.524      P=0.520N     P=0.359N    |P=0.544      P=0.449N     P=0.654N     P=0.617N     |
|POLY 3             |     P=0.197N     P=0.453      P=0.492N     P=0.314N    |P=0.485N     P=0.495N     P=0.568N     P=0.596N     |
|POLY 1.5           |     P=0.178N     P=0.427      P=0.486N     P=0.295N    |P=0.450N     P=0.497N     P=0.534N     P=0.569N     |
|POLY 6             |     P=0.222N     P=0.486      P=0.505N     P=0.334N    |P=0.526N     P=0.490N     P=0.611N     P=0.624N     |
|LOGISTIC REGRESSION|     P=0.129N     P=0.422      P=0.486N     P=0.208N    |P=0.298N     P=0.492N     P=0.535N     P=0.310N     |
|COCH-ARM / FISHERS |     P=0.115N     P=0.380      P=0.487N     P=0.226N    |P=0.372N     P=0.490N     P=0.490N     P=0.490N     |
|=================================================================================================================================|
       Date:  09/14/98                           EXPERIMENT: 05184 TEST: 05                                            Page 37
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                   GLUTARALDEHYDE
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      250 PPB      500 PPB      750 PPB     |CONTROL      250 PPB      500 PPB      750 PPB      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Stomach, Forestomach: Epithelium                                                                                                 |
|     Hyperplasia                                                                                                                 |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     11/49 (22%)  2/49 (4%)    2/50 (4%)    4/48 (8%)   |3/49 (6%)    4/50 (8%)    3/50 (6%)    5/50 (10%)   |
|POLY-3 ADJUSTED (b)|     29.0%        5.1%         5.5%         13.1%       |7.2%         9.4%         8.2%         14.8%        |
|TERMINAL (d)       |     1/12 (8%)    0/14 (0%)    0/9 (0%)     0/6 (0%)    |0/26 (0%)    2/31 (7%)    0/15 (0%)    0/14 (0%)    |
|FIRST INCIDENCE    |     580          666          525          106         |651          612          543          375          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.047N*    P=0.005N**   P=0.015N*    P=0.149N    |P=0.131      P=0.540      P=0.497      P=0.206      |
|POLY 3             |     P=0.019N*    P=0.005N**   P=0.007N**   P=0.095N    |P=0.215      P=0.515      P=0.603      P=0.248      |
|POLY 1.5           |     P=0.018N*    P=0.005N**   P=0.006N**   P=0.083N    |P=0.246      P=0.509      P=0.633      P=0.273      |
|POLY 6             |     P=0.022N*    P=0.004N**   P=0.009N**   P=0.113N    |P=0.184      P=0.528      P=0.563      P=0.226      |
|LOGISTIC REGRESSION|     P=0.005N**   P=0.007N**   P=0.008N**   P=0.031N*   |P=0.291      P=0.510      P=0.665N     P=0.344      |
|COCH-ARM / FISHERS |     P=0.016N*    P=0.007N**   P=0.007N**   P=0.049N*   |P=0.325      P=0.511      P=0.651N     P=0.369      |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      250 PPB      500 PPB      750 PPB     |CONTROL      250 PPB      500 PPB      750 PPB      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Stomach, Glandular                                                                                                               |
|     Erosion                                                                                                                     |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     1/49 (2%)    0/49 (0%)    1/50 (2%)    2/48 (4%)   |0/49 (0%)    1/49 (2%)    1/50 (2%)    0/50 (0%)    |
|POLY-3 ADJUSTED (b)|     2.9%         0.0%         2.8%         7.0%        |0.0%         2.4%         2.7%         0.0%         |
|TERMINAL (d)       |     0/12 (0%)    0/14 (0%)    0/9 (0%)     0/6 (0%)    |0/26 (0%)    0/31 (0%)    0/15 (0%)    0/14 (0%)    |
|FIRST INCIDENCE    |     717          ---          705          449         |---          720          355          ---          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.181      P=0.486N     P=0.726      P=0.401     |P=0.542      P=0.546      P=0.500      (e)          |
|POLY 3             |     P=0.227      P=0.480N     P=0.757N     P=0.432     |P=0.547      P=0.505      P=0.478      (e)          |
|POLY 1.5           |     P=0.232      P=0.487N     P=0.755N     P=0.438     |P=0.567      P=0.501      P=0.490      (e)          |
|POLY 6             |     P=0.220      P=0.471N     P=0.761N     P=0.431     |P=0.526      P=0.511      P=0.462      (e)          |
|LOGISTIC REGRESSION|     P=0.241      P=0.459N     P=0.754      P=0.491     |P=0.528N     P=0.516      P=0.470      (e)          |
|COCH-ARM / FISHERS |     P=0.245      P=0.500N     P=0.747N     P=0.492     |P=0.620N     P=0.500      P=0.505      (e)          |
|=================================================================================================================================|
       Date:  09/14/98                           EXPERIMENT: 05184 TEST: 05                                            Page 38
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                   GLUTARALDEHYDE
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      250 PPB      500 PPB      750 PPB     |CONTROL      250 PPB      500 PPB      750 PPB      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Stomach, Glandular                                                                                                               |
|     Inflammation                                                                                                                |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     0/49 (0%)    1/49 (2%)    1/50 (2%)    0/48 (0%)   |0/49 (0%)    1/49 (2%)    2/50 (4%)    0/50 (0%)    |
|POLY-3 ADJUSTED (b)|     0.0%         2.6%         2.8%         0.0%        |0.0%         2.4%         5.5%         0.0%         |
|TERMINAL (d)       |     0/12 (0%)    0/14 (0%)    0/9 (0%)     0/6 (0%)    |0/26 (0%)    0/31 (0%)    0/15 (0%)    0/14 (0%)    |
|FIRST INCIDENCE    |     ---          689          593          ---         |---          612          355          ---          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.559      P=0.533      P=0.511      (e)         |P=0.425      P=0.505      P=0.196      (e)          |
|POLY 3             |     P=0.563      P=0.521      P=0.507      (e)         |P=0.390      P=0.507      P=0.213      (e)          |
|POLY 1.5           |     P=0.572      P=0.514      P=0.507      (e)         |P=0.417      P=0.502      P=0.226      (e)          |
|POLY 6             |     P=0.555      P=0.532      P=0.506      (e)         |P=0.367      P=0.514      P=0.197      (e)          |
|LOGISTIC REGRESSION|     P=0.609      P=0.527      P=0.494      (e)         |P=0.601      P=0.505      P=0.272      (e)          |
|COCH-ARM / FISHERS |     P=0.623      P=0.500      P=0.505      (e)         |P=0.506      P=0.500      P=0.253      (e)          |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      250 PPB      500 PPB      750 PPB     |CONTROL      250 PPB      500 PPB      750 PPB      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Stomach, Glandular                                                                                                               |
|     Ulcer                                                                                                                       |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     0/49 (0%)    2/49 (4%)    0/50 (0%)    0/48 (0%)   |0/49 (0%)    0/49 (0%)    0/50 (0%)    0/50 (0%)    |
|POLY-3 ADJUSTED (b)|     0.0%         5.1%         0.0%         0.0%        |0.0%         0.0%         0.0%         0.0%         |
|TERMINAL (d)       |     0/12 (0%)    0/14 (0%)    0/9 (0%)     0/6 (0%)    |0/26 (0%)    0/31 (0%)    0/15 (0%)    0/14 (0%)    |
|FIRST INCIDENCE    |     ---          550          ---          ---         |---          ---          ---          ---          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.421N     P=0.281      (e)          (e)         |(e)          (e)          (e)          (e)          |
|POLY 3             |     P=0.437N     P=0.265      (e)          (e)         |(e)          (e)          (e)          (e)          |
|POLY 1.5           |     P=0.427N     P=0.255      (e)          (e)         |(e)          (e)          (e)          (e)          |
|POLY 6             |     P=0.447N     P=0.280      (e)          (e)         |(e)          (e)          (e)          (e)          |
|LOGISTIC REGRESSION|     P=0.355N     P=0.188      (e)          (e)         |(e)          (e)          (e)          (e)          |
|COCH-ARM / FISHERS |     P=0.377N     P=0.247      (e)          (e)         |(e)          (e)          (e)          (e)          |
|=================================================================================================================================|
       Date:  09/14/98                           EXPERIMENT: 05184 TEST: 05                                            Page 39
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                   GLUTARALDEHYDE
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      250 PPB      500 PPB      750 PPB     |CONTROL      250 PPB      500 PPB      750 PPB      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Stomach, Glandular: Epithelium                                                                                                   |
|     Mineralization                                                                                                              |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     9/49 (18%)   5/49 (10%)   3/50 (6%)    4/48 (8%)   |0/49 (0%)    0/49 (0%)    0/50 (0%)    0/50 (0%)    |
|POLY-3 ADJUSTED (b)|     25.2%        12.5%        8.4%         13.9%       |0.0%         0.0%         0.0%         0.0%         |
|TERMINAL (d)       |     3/12 (25%)   0/14 (0%)    1/9 (11%)    0/6 (0%)    |0/26 (0%)    0/31 (0%)    0/15 (0%)    0/14 (0%)    |
|FIRST INCIDENCE    |     612          579          632          492         |---          ---          ---          ---          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.168N     P=0.126N     P=0.118N     P=0.325N    |(e)          (e)          (e)          (e)          |
|POLY 3             |     P=0.081N     P=0.127N     P=0.051N     P=0.209N    |(e)          (e)          (e)          (e)          |
|POLY 1.5           |     P=0.075N     P=0.151N     P=0.051N     P=0.198N    |(e)          (e)          (e)          (e)          |
|POLY 6             |     P=0.089N     P=0.100N     P=0.052N     P=0.215N    |(e)          (e)          (e)          (e)          |
|LOGISTIC REGRESSION|     P=0.093N     P=0.133N     P=0.056N     P=0.233N    |(e)          (e)          (e)          (e)          |
|COCH-ARM / FISHERS |     P=0.051N     P=0.194N     P=0.056N     P=0.124N    |(e)          (e)          (e)          (e)          |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      250 PPB      500 PPB      750 PPB     |CONTROL      250 PPB      500 PPB      750 PPB      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Testes: Germinal Epithelium                                                                                                      |
|     Atrophy                                                                                                                     |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     12/50 (24%)  9/50 (18%)   13/50 (26%)  6/50 (12%)  |                                                    |
|POLY-3 ADJUSTED (b)|     32.5%        21.9%        34.5%        20.2%       |                                                    |
|TERMINAL (d)       |     4/12 (33%)   1/14 (7%)    3/9 (33%)    0/6 (0%)    |                                                    |
|FIRST INCIDENCE    |     555          356          526          474         |                                                    |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.477N     P=0.184N     P=0.375      P=0.311N    |                                                    |
|POLY 3             |     P=0.343N     P=0.209N     P=0.524      P=0.197N    |                                                    |
|POLY 1.5           |     P=0.314N     P=0.245N     P=0.521      P=0.188N    |                                                    |
|POLY 6             |     P=0.373N     P=0.169N     P=0.522      P=0.201N    |                                                    |
|LOGISTIC REGRESSION|     P=0.296N     P=0.254N     P=0.512      P=0.210N    |                                                    |
|COCH-ARM / FISHERS |     P=0.152N     P=0.312N     P=0.500      P=0.096N    |                                                    |
|=================================================================================================================================|
       Date:  09/14/98                           EXPERIMENT: 05184 TEST: 05                                            Page 40
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                   GLUTARALDEHYDE
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      250 PPB      500 PPB      750 PPB     |CONTROL      250 PPB      500 PPB      750 PPB      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Testes: Interstitial Cell                                                                                                        |
|     Hyperplasia                                                                                                                 |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     4/50 (8%)    0/50 (0%)    1/50 (2%)    4/50 (8%)   |                                                    |
|POLY-3 ADJUSTED (b)|     10.9%        0.0%         2.8%         13.3%       |                                                    |
|TERMINAL (d)       |     0/12 (0%)    0/14 (0%)    0/9 (0%)     0/6 (0%)    |                                                    |
|FIRST INCIDENCE    |     495          ---          661          393         |                                                    |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.387      P=0.050N     P=0.188N     P=0.503     |                                                    |
|POLY 3             |     P=0.477      P=0.052N     P=0.184N     P=0.530     |                                                    |
|POLY 1.5           |     P=0.486      P=0.055N     P=0.179N     P=0.540     |                                                    |
|POLY 6             |     P=0.462      P=0.050N     P=0.193N     P=0.522     |                                                    |
|LOGISTIC REGRESSION|     P=0.503N     P=0.078N     P=0.187N     P=0.595N    |                                                    |
|COCH-ARM / FISHERS |     P=0.500      P=0.059N     P=0.181N     P=0.643N    |                                                    |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      250 PPB      500 PPB      750 PPB     |CONTROL      250 PPB      500 PPB      750 PPB      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Thyroid Gland: C-Cell                                                                                                            |
|     Hyperplasia                                                                                                                 |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     6/50 (12%)   2/50 (4%)    8/50 (16%)   5/50 (10%)  |3/50 (6%)    4/50 (8%)    4/49 (8%)    4/49 (8%)    |
|POLY-3 ADJUSTED (b)|     16.4%        5.2%         21.8%        17.3%       |7.1%         9.5%         11.3%        12.2%        |
|TERMINAL (d)       |     0/12 (0%)    1/14 (7%)    3/9 (33%)    1/6 (17%)   |1/26 (4%)    4/31 (13%)   2/15 (13%)   2/14 (14%)   |
|FIRST INCIDENCE    |     543          724          481          449         |542          730 (T)      674          106          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.167      P=0.095N     P=0.319      P=0.550     |P=0.118      P=0.572      P=0.285      P=0.278      |
|POLY 3             |     P=0.261      P=0.111N     P=0.385      P=0.593     |P=0.253      P=0.495      P=0.399      P=0.361      |
|POLY 1.5           |     P=0.284      P=0.118N     P=0.393      P=0.613     |P=0.292      P=0.492      P=0.437      P=0.393      |
|POLY 6             |     P=0.236      P=0.105N     P=0.365      P=0.575     |P=0.214      P=0.504      P=0.354      P=0.329      |
|LOGISTIC REGRESSION|     P=0.272      P=0.107N     P=0.395      P=0.622     |P=0.314      P=0.502      P=0.419      P=0.528      |
|COCH-ARM / FISHERS |     P=0.418      P=0.134N     P=0.387      P=0.500N    |P=0.391      P=0.500      P=0.489      P=0.489      |
|=================================================================================================================================|
       Date:  09/14/98                           EXPERIMENT: 05184 TEST: 05                                            Page 41
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                   GLUTARALDEHYDE
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      250 PPB      500 PPB      750 PPB     |CONTROL      250 PPB      500 PPB      750 PPB      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Tooth                                                                                                                            |
|     Degeneration                                                                                                                |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     1/1 (100%)   0/0 (0%)     0/0 (0%)     8/8 (100%)  |1/1 (100%)   2/2 (100%)   0/0 (0%)     2/3 (67%)    |
|POLY-3 ADJUSTED (b)|     100.0%       0.0%         0.0%         100.0%      |100.0%       100.0%       0.0%         99.8%        |
|TERMINAL (d)       |     0/0 (0%)     0/0 (0%)     0/0 (0%)     0/0 (0%)    |0/0 (0%)     0/0 (0%)     0/0 (0%)     0/0 (0%)     |
|FIRST INCIDENCE    |     117          ---          ---          99          |119          117          ---          113          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     (e)          (e)          (e)          (e)         |P=0.384      (e)          (e)          P=0.464      |
|POLY 3             |     (e)          (e)          (e)          (e)         |(e)          (e)          (e)          P=1.000N     |
|POLY 1.5           |     (e)          (e)          (e)          (e)         |(e)          (e)          (e)          P=1.000N     |
|POLY 6             |     (e)          (e)          (e)          (e)         |(e)          (e)          (e)          P=1.000N     |
|LOGISTIC REGRESSION|     (e)          (e)          (e)          (e)         |(e)          (e)          (e)          (e)          |
|COCH-ARM / FISHERS |     (e)          (e)          (e)          (e)         |P=0.274N     (e)          (e)          P=0.750N     |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      250 PPB      500 PPB      750 PPB     |CONTROL      250 PPB      500 PPB      750 PPB      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Urinary Bladder: Transitional Epithelium                                                                                         |
|     Hyperplasia                                                                                                                 |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     2/50 (4%)    0/49 (0%)    1/50 (2%)    0/48 (0%)   |0/49 (0%)    0/50 (0%)    0/50 (0%)    0/50 (0%)    |
|POLY-3 ADJUSTED (b)|     5.5%         0.0%         2.8%         0.0%        |0.0%         0.0%         0.0%         0.0%         |
|TERMINAL (d)       |     0/12 (0%)    0/14 (0%)    0/9 (0%)     0/6 (0%)    |0/26 (0%)    0/31 (0%)    0/15 (0%)    0/14 (0%)    |
|FIRST INCIDENCE    |     543          ---          705          ---         |---          ---          ---          ---          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.180N     P=0.213N     P=0.507N     P=0.299N    |(e)          (e)          (e)          (e)          |
|POLY 3             |     P=0.203N     P=0.222N     P=0.504N     P=0.303N    |(e)          (e)          (e)          (e)          |
|POLY 1.5           |     P=0.194N     P=0.228N     P=0.500N     P=0.294N    |(e)          (e)          (e)          (e)          |
|POLY 6             |     P=0.211N     P=0.215N     P=0.515N     P=0.314N    |(e)          (e)          (e)          (e)          |
|LOGISTIC REGRESSION|     P=0.145N     P=0.301N     P=0.507N     P=0.230N    |(e)          (e)          (e)          (e)          |
|COCH-ARM / FISHERS |     P=0.153N     P=0.253N     P=0.500N     P=0.258N    |(e)          (e)          (e)          (e)          |
|=================================================================================================================================|

(a)  Number of tumor-bearing animals /  number of animals examined at site.
(b)  Poly-3 adjusted lifetime tumor incidence.
(d)  Observed incidence at terminal kill.
(f)  Beneath the control incidence are the P-values associated with the trend 
test.  Beneath the dosed group incidence are the P-values corresponding to 
pairwise comparisons between the controls and that dosed group.  The life
table analysis regards tumors in animals dying prior to  terminal kill as
 being (directly or indirectly) the cause of death.
Logistic regression is an alternative
 method for analyzing the incidence of non-fatal tumors. The Cochran-Armitage
and Fishers exact tests compare directly the overall incidence rates
For all tests a negative trend is indicated by N
(e)  Value of Statistic cannot be computed.
(I)  Interim sacrifice
(T)  Terminal sacrifice
#   Tumor rates based on number of animals necropsied.
*   To the right of any statistical result, indicates significance at (P<=0.05).
**  To the right of any statistical result, indicates significance at (P<=0.01).