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TDMS Study 05184-06 Pathology Tables

NTP                                          MEAN BODY WEIGHTS AND SURVIVAL TABLE                                 REPORT: EISRPT41  
LAB: Battelle Northwest                                 GLUTARALDEHYDE                                            DATE: 07/13/98    
EXPERIMENT: 05184 TEST: 06                                                                                        TIME: 08:29:29    
                                                CAGES FROM 0000 TO LAST CAGE                                      PAGE:    1        
TEST TYPE: CHRONIC                                  ROUTE: RESPIRATORY EXPOSURE WHOLE BODY                        NTP:  C55425C     
CONT: NO1-ES-25335                                                                                                CAS: 111-30-8     
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               REASONS FOR REMOVAL:    ALL                                                                                          
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
               REMOVAL DATE RANGE:     ALL                                                                                          
                                                                                                                                    
               TREATMENT GROUPS:       INCLUDE ALL                                                                                  




NTP                                          MEAN BODY WEIGHTS AND SURVIVAL TABLE                                 REPORT: EISRPT41

LAB: BATTELLE NORTHWEST                               GLUTARALDEHYDE                                              DATE: 07/13/98


EXPERIMENT: 05184 TEST: 06                                                                                        TIME:  8:39:43



TEST TYPE: TWO YEAR                                 ROUTE: RESPIRATORY EX                                         NTP:  55425C

CONT: NO1-ES-25335                                                                                                CAS: 111-30-8

                             MEAN BODY WEIGHTS AND SURVIVAL OF MALE MICE IN THE
                              TWO YEAR RESPIRATORY EX STUDY OF GLUTARALDEHYDE

==========================================================================================================
WEEK     CONTROL                62.5 PPB                 125 PPB                  250 PPB
         ----------------       ----------------         ----------------         ----------------
          AV.WT.     NO.       AV.WT.  PERCENT  NO.     AV.WT.  PERCENT  NO.     AV.WT.  PERCENT  NO.
         (GRAMS)     (A)       (GRAMS)  OF CNTL  (A)    (GRAMS)  OF CNTL  (A)    (GRAMS)  OF CNTL  (A)
=========================================================================================================

  B        26.1       50        25.8     98.9    50      25.9     99.2    50      26.0     99.6    50
  1        26.1       50        25.8     98.9    50      25.9     99.2    50      26.0     99.6    50
  4        31.0       50        30.6     98.7    50      30.3     97.7    50      29.7     95.8    50
  8        33.7       50        33.2     98.5    50      32.8     97.3    50      32.3     95.8    50
 12        37.1       50        36.5     98.4    50      35.8     96.5    50      35.3     95.1    50
 16        39.6       50        38.8     98.0    50      37.8     95.5    50      37.8     95.5    50
 20        41.7       50        41.1     98.6    50      39.8     95.4    50      39.5     94.7    50
 24        43.4       50        43.2     99.5    50      41.5     95.6    50      41.0     94.5    50
 28        45.6       50        45.3     99.3    50      43.2     94.7    50      43.0     94.3    50
 32        45.9       50        46.3    100.9    50      44.3     96.5    50      43.8     95.4    50
 36        47.0       50        47.4    100.9    50      45.9     97.7    50      45.0     95.7    50
 40        47.8       50        48.8    102.1    50      47.2     98.7    49      46.3     96.9    50
 44        49.7       50        50.1    100.8    50      48.8     98.2    49      48.3     97.2    50
 48        50.6       50        50.9    100.6    50      50.0     98.8    49      48.9     96.6    49
 52        52.2       49        52.2    100.0    50      51.9     99.4    49      51.3     98.3    49
 56        52.0       49        51.8     99.6    49      51.6     99.2    49      51.3     98.7    49
 60        52.3       49        52.1     99.6    48      52.2     99.8    49      51.6     98.7    49
 64        51.7       49        51.7    100.0    47      51.6     99.8    49      50.5     97.7    49
 68        52.4       48        51.6     98.5    47      51.6     98.5    48      50.6     96.6    49
 72        52.5       47        52.1     99.2    46      51.4     97.9    47      51.1     97.3    49
 76        51.4       46        51.9    101.0    43      51.8    100.8    44      51.2     99.6    48
 80        51.7       44        51.7    100.0    41      51.8    100.2    44      50.8     98.3    47
 84        50.5       43        51.5    102.0    40      50.9    100.8    44      50.4     99.8    47
 88        50.4       42        51.4    102.0    38      51.4    102.0    43      49.7     98.6    46
 93        49.8       40        51.5    103.4    35      51.7    103.8    43      50.4    101.2    44
 94        50.1       40        50.0     99.8    34      50.5    100.8    43      49.5     98.8    43
 96        50.2       39        49.8     99.2    33      50.1     99.8    43      49.6     98.8    42
 98        50.4       36        49.6     98.4    32      49.9     99.0    43      50.8    100.8    36*
100        49.7       35        49.4     99.4    31      49.5     99.6    43      50.2    101.0    40
102        49.9       33        50.0    100.2    29      48.6     97.4    42      49.5     99.2    39
104        50.1       31        49.8     99.4    27      48.8     97.4    40      49.7     99.2    38

TERM. SAC.            31                         27                       40                       38


==========================================================================================================


    (A) NUMBER OF ANIMALS WEIGHED.  AT TERMINAL SACRIFICE, NUMBER
        OF ANIMALS ALIVE ON FIRST DAY OF TERMINAL SACRIFICE.
    (B) REFERS TO THE BEGINNING (INITIAL) BODY WEIGHT.
    (I) INTERIM SACRIFICE OCCURRED IN THIS WEEK.
    (*) THE NUMBER OF ANIMALS WEIGHED FOR THIS WEEK
         IS LESS THAN THE NUMBER OF ANIMALS SURVIVING.

                             MEAN BODY WEIGHTS AND SURVIVAL OF FEMALE MICE IN THE
                              TWO YEAR RESPIRATORY EX STUDY OF GLUTARALDEHYDE

==========================================================================================================
WEEK     CONTROL                62.5 PPB                 125 PPB                  250 PPB
         ----------------       ----------------         ----------------         ----------------
          AV.WT.     NO.       AV.WT.  PERCENT  NO.     AV.WT.  PERCENT  NO.     AV.WT.  PERCENT  NO.
         (GRAMS)     (A)       (GRAMS)  OF CNTL  (A)    (GRAMS)  OF CNTL  (A)    (GRAMS)  OF CNTL  (A)
=========================================================================================================

  B        20.4       50        20.3     99.5    50      20.2     99.0    50      20.2     99.0    50
  1        20.4       50        20.3     99.5    50      20.2     99.0    50      20.2     99.0    50
  4        24.5       50        24.9    101.6    50      24.7    100.8    50      24.6    100.4    50
  8        26.7       50        27.2    101.9    50      27.0    101.1    50      26.5     99.3    50
 12        29.0       50        29.5    101.7    50      29.0    100.0    50      28.1     96.9    50
 16        30.8       50        30.9    100.3    50      30.7     99.7    50      29.1     94.5    50
 20        32.6       50        33.2    101.8    50      32.6    100.0    50      30.8     94.5    50
 24        34.7       50        34.7    100.0    50      34.6     99.7    50      31.6     91.1    50
 28        36.4       50        36.2     99.5    50      35.7     98.1    50      32.6     89.6    50
 32        36.9       50        37.8    102.4    50      36.2     98.1    50      32.8     88.9    50
 36        38.3       49        38.4    100.3    50      37.7     98.4    50      33.4     87.2    50
 40        40.2       49        41.0    102.0    50      38.2     95.0    50      36.0     89.6    50
 44        43.1       49        43.7    101.4    50      41.1     95.4    50      38.8     90.0    50
 48        43.2       49        44.9    103.9    50      41.7     96.5    50      39.5     91.4    50
 52        46.8       49        48.9    104.5    50      45.3     96.8    50      44.0     94.0    50
 56        49.2       49        49.6    100.8    50      46.4     94.3    50      44.8     91.1    50
 60        50.3       49        51.0    101.4    50      48.2     95.8    50      45.4     90.3    49
 64        51.3       49        51.3    100.0    50      48.0     93.6    50      45.9     89.5    49
 68        51.7       49        50.7     98.1    49      47.7     92.3    50      46.1     89.2    49
 72        52.9       49        52.6     99.4    48      50.3     95.1    49      47.6     90.0    47
 76        51.5       48        51.3     99.6    47      48.9     95.0    48      47.7     92.6    47
 80        52.5       46        51.2     97.5    46      49.7     94.7    48      47.5     90.5    45
 84        51.1       46        50.6     99.0    46      49.2     96.3    47      47.8     93.5    44
 88        50.0       45        50.6    101.2    44      49.4     98.8    47      46.9     93.8    43
 93        50.8       44        49.9     98.2    44      49.4     97.2    45      47.8     94.1    41
 94        50.5       42        48.8     96.6    44      48.4     95.8    45      47.0     93.1    41
 96        50.2       41        48.5     96.6    44      47.3     94.2    44      46.7     93.0    40
 98        50.0       40        48.5     97.0    43      48.0     96.0    42      47.6     95.2    39
100        50.3       39        48.1     95.6    43      48.0     95.4    40      48.2     95.8    38
102        49.5       35        47.5     96.0    39      46.8     94.5    38      47.2     95.4    35
104        49.6       35        48.3     97.4    37      47.1     95.0    35      47.7     96.2    32

TERM. SAC.            35                         37                       35                       32


==========================================================================================================


    (A) NUMBER OF ANIMALS WEIGHED.  AT TERMINAL SACRIFICE, NUMBER
        OF ANIMALS ALIVE ON FIRST DAY OF TERMINAL SACRIFICE.
    (B) REFERS TO THE BEGINNING (INITIAL) BODY WEIGHT.
    (I) INTERIM SACRIFICE OCCURRED IN THIS WEEK.
    (*) THE NUMBER OF ANIMALS WEIGHED FOR THIS WEEK
         IS LESS THAN THE NUMBER OF ANIMALS SURVIVING.