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TDMS Study 05184-06 Pathology Tables

NTP                                        STATISTICAL ANALYSIS OF PRIMARY TUMORS                              REPORT: PEIRPT08     
LAB: Battelle Northwest                                      GLUTARALDEHYDE                                    DATE: 07/13/98       
EXPERIMENT: 05184 TEST: 06                                                                                     TIME: 08:38:05       
TEST TYPE:  CHRONIC                             CAGES FROM 0000 TO LAST CAGE                                   PAGE:       1        
CONT: NO1-ES-25335                              ROUTE: RESPIRATORY EXPOSURE WHOLE BODY                         NTP C#: 55425C       
PATHOLOGIST: GRUMBEIN, S.                                                                                      CAS: 111-30-8        
------------------------------------------------------------------------------------------------------------------------------------
                                                                                                                                    
                                                             CORE STUDY                                                             
                                                                                                                                    

               REASONS FOR REMOVAL:    ALL                                                                                          
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
               REMOVAL DATE RANGE:     ALL                                                                                          
                                                                                                                                    
               TREATMENT GROUPS:       INCLUDE ALL                                                                                  
NTP                                        STATISTICAL ANALYSIS OF PRIMARY TUMORS                              REPORT: PEIRPT08
LAB: Battelle Northwest                                      GLUTARALDEHYDE                                    DATE: 07/13/98

EXPERIMENT: 05184 TEST: 06                                                                                     TIME: 08:38:05
TEST TYPE:  CHRONIC                             CAGES FROM 0000 TO LAST CAGE
CONT: NO1-ES-25335                              ROUTE: RESPIRATORY EXPOSURE WHOLE BODY                         NTP C#: 55425C
PATHOLOGIST: GRUMBEIN, S.                                                                                      CAS: 111-30-8

Mice(B6C3F1)
-----------------------------
FOR ALL DOSES THE TUMOR RATES IN THE FOLLOWING TISSUES/ORGANS ARE
BASED ON NUMBER OF TISSUES EXAMINED.  IN OTHER TISSUES/ORGANS RATES
ARE BASED ON THE NUMBER OF ANIMALS NECROPSIED.
                                                 ---------------
                                                 Adrenal Cortex
                                                 Adrenal Medulla
                                                 Bone Marrow
                                                 Clitoral/Preputial Gland
                                                 Gallbladder
                                                 Heart
                                                 Islets, Pancreatic
                                                 Kidney
                                                 Liver
                                                 Lung
                                                 Ovary
                                                 Pituitary Gland
                                                 Spleen
                                                 Testes
                                                 Thyroid Gland
NTP                                        STATISTICAL ANALYSIS OF PRIMARY TUMORS                              REPORT: PEIRPT08   
LAB: Battelle Northwest                                      GLUTARALDEHYDE                                    DATE: 07/13/98     
EXPERIMENT: 05184 TEST: 06                                                                                     TIME: 08:38:05     
TEST TYPE:  CHRONIC                             CAGES FROM 0000 TO LAST CAGE                                                      
CONT: NO1-ES-25335                              ROUTE: RESPIRATORY EXPOSURE WHOLE BODY                         NTP C#: 55425C     
PATHOLOGIST: GRUMBEIN, S.                                                                                      CAS: 111-30-8      



SUMMARY OF STATISTICALLY SIGNIFICANT (P<=.05) RESULTS
IN THE ANALYSIS OF                  GLUTARALDEHYDE
===============================================================

Male Mice
------------
Organ                                 Morphology
-----                                 ----------
Liver                                  Hepatocellular Adenoma
                                       Hepatocellular Carcinoma or Hepatocellular Adenoma
                                       Hepatocellular Carcinoma, Hepatocellular Adenoma, or Hepatoblastoma
All Organs                             Histiocytic Sarcoma
                                       Benign Tumors
                                       Malignant Tumors
                                       Malignant and Benign Tumors
===============================================================
Female Mice
------------
Organ                                  Morphology
-----                                  ----------
Intestine Small: Site Unspecified      Polyp Adenomatous
Liver                                  Hepatocellular Adenoma
                                       Hepatocellular Carcinoma or Hepatocellular Adenoma
                                       Hepatocellular Carcinoma, Hepatocellular Adenoma, or Hepatoblastoma
===============================================================
       Date:  07/13/98                           EXPERIMENT: 05184 TEST: 06                                            Page 1
                     Statistical Analysis of Primary Tumors in Mice(B6C3F1)        -                   GLUTARALDEHYDE
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      62.5 PPB     125 PPB      250 PPB     |CONTROL      62.5 PPB     125 PPB      250 PPB      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Adrenal Cortex                                                                                                                   |
|     Adenoma                                                                                                                     |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     2/47 (4%)    0/49 (0%)    3/50 (6%)    1/49 (2%)   |0/50 (0%)    1/49 (2%)    0/49 (0%)    0/50 (0%)    |
|POLY-3 ADJUSTED (b)|     4.9%         0.0%         6.7%         2.2%        |0.0%         2.2%         0.0%         0.0%         |
|TERMINAL (d)       |     2/31 (7%)    0/27 (0%)    3/40 (8%)    1/38 (3%)   |0/34 (0%)    1/37 (3%)    0/35 (0%)    0/32 (0%)    |
|FIRST INCIDENCE    |     733 (T)      ---          733 (T)      733 (T)     |---          735 (T)      ---          ---          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.453N     P=0.269N     P=0.616      P=0.429N    |P=0.581N     P=0.517      (e)          (e)          |
|POLY 3             |     P=0.500N     P=0.246N     P=0.544      P=0.467N    |P=0.561N     P=0.502      (e)          (e)          |
|POLY 1.5           |     P=0.518N     P=0.238N     P=0.535      P=0.475N    |P=0.563N     P=0.500      (e)          (e)          |
|POLY 6             |     P=0.480N     P=0.254N     P=0.558      P=0.458N    |P=0.559N     P=0.506      (e)          (e)          |
|LOGISTIC REGRESSION|     P=0.453N     (e)          P=0.616      P=0.429N    |(e)          P=0.517      (e)          (e)          |
|COCH-ARM / FISHERS |     P=0.543N     P=0.237N     P=0.530      P=0.484N    |P=0.566N     P=0.495      (e)          (e)          |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      62.5 PPB     125 PPB      250 PPB     |CONTROL      62.5 PPB     125 PPB      250 PPB      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Adrenal Medulla                                                                                                                  |
|     Pheochromocytoma Benign                                                                                                     |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     0/47 (0%)    0/49 (0%)    0/50 (0%)    0/49 (0%)   |4/50 (8%)    1/49 (2%)    1/48 (2%)    2/49 (4%)    |
|POLY-3 ADJUSTED (b)|     0.0%         0.0%         0.0%         0.0%        |9.0%         2.2%         2.2%         4.7%         |
|TERMINAL (d)       |     0/31 (0%)    0/27 (0%)    0/40 (0%)    0/38 (0%)   |4/34 (12%)   1/37 (3%)    0/35 (0%)    2/31 (7%)    |
|FIRST INCIDENCE    |     ---          ---          ---          ---         |735 (T)      735 (T)      635          735 (T)      |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     (e)          (e)          (e)          (e)         |P=0.352N     P=0.154N     P=0.170N     P=0.379N     |
|POLY 3             |     (e)          (e)          (e)          (e)         |P=0.328N     P=0.175N     P=0.179N     P=0.358N     |
|POLY 1.5           |     (e)          (e)          (e)          (e)         |P=0.325N     P=0.179N     P=0.183N     P=0.352N     |
|POLY 6             |     (e)          (e)          (e)          (e)         |P=0.332N     P=0.169N     P=0.174N     P=0.364N     |
|LOGISTIC REGRESSION|     (e)          (e)          (e)          (e)         |P=0.334N     P=0.154N     P=0.184N     P=0.379N     |
|COCH-ARM / FISHERS |     (e)          (e)          (e)          (e)         |P=0.320N     P=0.187N     P=0.194N     P=0.349N     |
|=================================================================================================================================|
       Date:  07/13/98                           EXPERIMENT: 05184 TEST: 06                                            Page 2
                     Statistical Analysis of Primary Tumors in Mice(B6C3F1)       -                   GLUTARALDEHYDE
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      62.5 PPB     125 PPB      250 PPB     |CONTROL      62.5 PPB     125 PPB      250 PPB      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Adrenal Medulla                                                                                                                  |
|     Pheochromocytoma: Benign, Complex, Malignant, NOS                                                                           |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     0/47 (0%)    0/49 (0%)    0/50 (0%)    0/49 (0%)   |4/50 (8%)    2/49 (4%)    1/48 (2%)    2/49 (4%)    |
|POLY-3 ADJUSTED (b)|     0.0%         0.0%         0.0%         0.0%        |9.0%         4.4%         2.2%         4.7%         |
|TERMINAL (d)       |     0/31 (0%)    0/27 (0%)    0/40 (0%)    0/38 (0%)   |4/34 (12%)   2/37 (5%)    0/35 (0%)    2/31 (7%)    |
|FIRST INCIDENCE    |     ---          ---          ---          ---         |735 (T)      735 (T)      635          735 (T)      |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     (e)          (e)          (e)          (e)         |P=0.301N     P=0.298N     P=0.170N     P=0.379N     |
|POLY 3             |     (e)          (e)          (e)          (e)         |P=0.278N     P=0.332N     P=0.179N     P=0.358N     |
|POLY 1.5           |     (e)          (e)          (e)          (e)         |P=0.275N     P=0.337N     P=0.183N     P=0.352N     |
|POLY 6             |     (e)          (e)          (e)          (e)         |P=0.281N     P=0.323N     P=0.174N     P=0.364N     |
|LOGISTIC REGRESSION|     (e)          (e)          (e)          (e)         |P=0.285N     P=0.298N     P=0.184N     P=0.379N     |
|COCH-ARM / FISHERS |     (e)          (e)          (e)          (e)         |P=0.271N     P=0.349N     P=0.194N     P=0.349N     |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      62.5 PPB     125 PPB      250 PPB     |CONTROL      62.5 PPB     125 PPB      250 PPB      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Bone Marrow                                                                                                                      |
|     Hemangiosarcoma                                                                                                             |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     1/48 (2%)    1/47 (2%)    0/50 (0%)    1/49 (2%)   |1/50 (2%)    3/48 (6%)    1/50 (2%)    0/49 (0%)    |
|POLY-3 ADJUSTED (b)|     2.4%         2.6%         0.0%         2.2%        |2.2%         6.6%         2.2%         0.0%         |
|TERMINAL (d)       |     0/31 (0%)    0/27 (0%)    0/40 (0%)    0/38 (0%)   |1/34 (3%)    2/37 (5%)    0/35 (0%)    0/32 (0%)    |
|FIRST INCIDENCE    |     516          685          ---          663         |735 (T)      672          715          ---          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.588N     P=0.748      P=0.504N     P=0.750N    |P=0.212N     P=0.336      P=0.748N     P=0.512N     |
|POLY 3             |     P=0.599N     P=0.736      P=0.488N     P=0.746N    |P=0.203N     P=0.309      P=0.754N     P=0.507N     |
|POLY 1.5           |     P=0.603N     P=0.744      P=0.490N     P=0.750N    |P=0.202N     P=0.302      P=0.756N     P=0.506N     |
|POLY 6             |     P=0.595N     P=0.729      P=0.482N     P=0.740N    |P=0.204N     P=0.319      P=0.752N     P=0.509N     |
|LOGISTIC REGRESSION|     P=0.650N     P=0.728N     P=0.456N     P=0.741     |P=0.205N     P=0.304      P=0.755N     (e)          |
|COCH-ARM / FISHERS |     P=0.608N     P=0.747      P=0.490N     P=0.747N    |P=0.202N     P=0.293      P=0.753N     P=0.505N     |
|=================================================================================================================================|
       Date:  07/13/98                           EXPERIMENT: 05184 TEST: 06                                            Page 3
                     Statistical Analysis of Primary Tumors in Mice(B6C3F1)       -                   GLUTARALDEHYDE
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      62.5 PPB     125 PPB      250 PPB     |CONTROL      62.5 PPB     125 PPB      250 PPB      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Harderian Gland                                                                                                                  |
|     Adenoma                                                                                                                     |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     3/50 (6%)    3/50 (6%)    2/50 (4%)    1/50 (2%)   |1/50 (2%)    0/50 (0%)    0/50 (0%)    0/50 (0%)    |
|POLY-3 ADJUSTED (b)|     7.0%         7.5%         4.4%         2.2%        |2.2%         0.0%         0.0%         0.0%         |
|TERMINAL (d)       |     1/31 (3%)    3/27 (11%)   2/40 (5%)    1/38 (3%)   |1/34 (3%)    0/37 (0%)    0/35 (0%)    0/32 (0%)    |
|FIRST INCIDENCE    |     684          733 (T)      733 (T)      733 (T)     |735 (T)      ---          ---          ---          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.127N     P=0.595      P=0.402N     P=0.257N    |P=0.314N     P=0.483N     P=0.494N     P=0.512N     |
|POLY 3             |     P=0.171N     P=0.628      P=0.480N     P=0.285N    |P=0.304N     P=0.495N     P=0.494N     P=0.504N     |
|POLY 1.5           |     P=0.180N     P=0.642      P=0.490N     P=0.293N    |P=0.305N     P=0.497N     P=0.496N     P=0.502N     |
|POLY 6             |     P=0.160N     P=0.611      P=0.463N     P=0.276N    |P=0.304N     P=0.493N     P=0.493N     P=0.507N     |
|LOGISTIC REGRESSION|     P=0.148N     P=0.613      P=0.467N     P=0.280N    |P=0.314N     (e)          (e)          (e)          |
|COCH-ARM / FISHERS |     P=0.194N     P=0.661N     P=0.500N     P=0.309N    |P=0.306N     P=0.500N     P=0.500N     P=0.500N     |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      62.5 PPB     125 PPB      250 PPB     |CONTROL      62.5 PPB     125 PPB      250 PPB      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Harderian Gland                                                                                                                  |
|     Carcinoma                                                                                                                   |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     1/50 (2%)    2/50 (4%)    0/50 (0%)    1/50 (2%)   |2/50 (4%)    0/50 (0%)    0/50 (0%)    1/50 (2%)    |
|POLY-3 ADJUSTED (b)|     2.3%         5.0%         0.0%         2.2%        |4.5%         0.0%         0.0%         2.3%         |
|TERMINAL (d)       |     1/31 (3%)    1/27 (4%)    0/40 (0%)    1/38 (3%)   |1/34 (3%)    0/37 (0%)    0/35 (0%)    1/32 (3%)    |
|FIRST INCIDENCE    |     733 (T)      706          ---          733 (T)     |708          ---          ---          735 (T)      |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.424N     P=0.457      P=0.449N     P=0.716N    |P=0.479N     P=0.216N     P=0.231N     P=0.514N     |
|POLY 3             |     P=0.487N     P=0.477      P=0.490N     P=0.747N    |P=0.461N     P=0.233N     P=0.231N     P=0.509N     |
|POLY 1.5           |     P=0.493N     P=0.486      P=0.495N     P=0.752N    |P=0.461N     P=0.234N     P=0.233N     P=0.504N     |
|POLY 6             |     P=0.482N     P=0.468      P=0.481N     P=0.739N    |P=0.462N     P=0.230N     P=0.230N     P=0.513N     |
|LOGISTIC REGRESSION|     P=0.450N     P=0.459      (e)          P=0.716N    |P=0.472N     P=0.231N     P=0.231N     P=0.512N     |
|COCH-ARM / FISHERS |     P=0.500N     P=0.500      P=0.500N     P=0.753N    |P=0.461N     P=0.247N     P=0.247N     P=0.500N     |
|=================================================================================================================================|
       Date:  07/13/98                           EXPERIMENT: 05184 TEST: 06                                            Page 4
                     Statistical Analysis of Primary Tumors in Mice(B6C3F1)       -                   GLUTARALDEHYDE
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      62.5 PPB     125 PPB      250 PPB     |CONTROL      62.5 PPB     125 PPB      250 PPB      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Harderian Gland                                                                                                                  |
|     Carcinoma or Adenoma                                                                                                        |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     4/50 (8%)    5/50 (10%)   2/50 (4%)    2/50 (4%)   |3/50 (6%)    0/50 (0%)    0/50 (0%)    1/50 (2%)    |
|POLY-3 ADJUSTED (b)|     9.3%         12.5%        4.4%         4.4%        |6.7%         0.0%         0.0%         2.3%         |
|TERMINAL (d)       |     2/31 (7%)    4/27 (15%)   2/40 (5%)    2/38 (5%)   |2/34 (6%)    0/37 (0%)    0/35 (0%)    1/32 (3%)    |
|FIRST INCIDENCE    |     684          706          733 (T)      733 (T)     |708          ---          ---          735 (T)      |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.104N     P=0.417      P=0.243N     P=0.266N    |P=0.262N     P=0.106N     P=0.116N     P=0.323N     |
|POLY 3             |     P=0.154N     P=0.455      P=0.316N     P=0.311N    |P=0.247N     P=0.115N     P=0.114N     P=0.314N     |
|POLY 1.5           |     P=0.164N     P=0.473      P=0.327N     P=0.322N    |P=0.247N     P=0.116N     P=0.115N     P=0.310N     |
|POLY 6             |     P=0.143N     P=0.434      P=0.300N     P=0.300N    |P=0.248N     P=0.113N     P=0.113N     P=0.318N     |
|LOGISTIC REGRESSION|     P=0.126N     P=0.430      P=0.298N     P=0.295N    |P=0.255N     P=0.113N     P=0.114N     P=0.317N     |
|COCH-ARM / FISHERS |     P=0.178N     P=0.500      P=0.339N     P=0.339N    |P=0.247N     P=0.121N     P=0.121N     P=0.309N     |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      62.5 PPB     125 PPB      250 PPB     |CONTROL      62.5 PPB     125 PPB      250 PPB      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Intestine Small: Site Unspecified                                                                                                |
|     Polyp Adenomatous                                                                                                           |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     0/50 (0%)    0/50 (0%)    0/50 (0%)    0/50 (0%)   |0/50 (0%)    0/50 (0%)    0/50 (0%)    2/50 (4%)    |
|POLY-3 ADJUSTED (b)|     0.0%         0.0%         0.0%         0.0%        |0.0%         0.0%         0.0%         4.6%         |
|TERMINAL (d)       |     0/31 (0%)    0/27 (0%)    0/40 (0%)    0/38 (0%)   |0/34 (0%)    0/37 (0%)    0/35 (0%)    2/32 (6%)    |
|FIRST INCIDENCE    |     ---          ---          ---          ---         |---          ---          ---          735 (T)      |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     (e)          (e)          (e)          (e)         |P=0.039 *    (e)          (e)          P=0.225      |
|POLY 3             |     (e)          (e)          (e)          (e)         |P=0.044 *    (e)          (e)          P=0.232      |
|POLY 1.5           |     (e)          (e)          (e)          (e)         |P=0.045 *    (e)          (e)          P=0.235      |
|POLY 6             |     (e)          (e)          (e)          (e)         |P=0.043 *    (e)          (e)          P=0.230      |
|LOGISTIC REGRESSION|     (e)          (e)          (e)          (e)         |(e)          (e)          (e)          P=0.225      |
|COCH-ARM / FISHERS |     (e)          (e)          (e)          (e)         |P=0.046 *    (e)          (e)          P=0.247      |
|=================================================================================================================================|
       Date:  07/13/98                           EXPERIMENT: 05184 TEST: 06                                            Page 5
                     Statistical Analysis of Primary Tumors in Mice(B6C3F1)       -                   GLUTARALDEHYDE
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      62.5 PPB     125 PPB      250 PPB     |CONTROL      62.5 PPB     125 PPB      250 PPB      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Liver                                                                                                                            |
|     Hemangiosarcoma                                                                                                             |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     2/49 (4%)    0/50 (0%)    3/50 (6%)    2/49 (4%)   |0/50 (0%)    2/48 (4%)    1/50 (2%)    1/50 (2%)    |
|POLY-3 ADJUSTED (b)|     4.8%         0.0%         6.7%         4.4%        |0.0%         4.5%         2.2%         2.3%         |
|TERMINAL (d)       |     1/31 (3%)    0/27 (0%)    3/40 (8%)    1/38 (3%)   |0/34 (0%)    2/37 (5%)    0/35 (0%)    1/32 (3%)    |
|FIRST INCIDENCE    |     716          ---          733 (T)      663         |---          735 (T)      687          735 (T)      |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.523      P=0.270N     P=0.611      P=0.634N    |P=0.476      P=0.257      P=0.510      P=0.488      |
|POLY 3             |     P=0.477      P=0.248N     P=0.531      P=0.668N    |P=0.495      P=0.238      P=0.506      P=0.496      |
|POLY 1.5           |     P=0.453      P=0.242N     P=0.520      P=0.679N    |P=0.500      P=0.235      P=0.505      P=0.498      |
|POLY 6             |     P=0.505      P=0.257N     P=0.548      P=0.655N    |P=0.490      P=0.243      P=0.508      P=0.493      |
|LOGISTIC REGRESSION|     P=0.475      P=0.260N     P=0.575      P=0.678N    |P=0.490      P=0.257      P=0.490      P=0.488      |
|COCH-ARM / FISHERS |     P=0.421      P=0.242N     P=0.510      P=0.691N    |P=0.504      P=0.237      P=0.500      P=0.500      |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      62.5 PPB     125 PPB      250 PPB     |CONTROL      62.5 PPB     125 PPB      250 PPB      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Liver                                                                                                                            |
|     Hepatocellular Adenoma                                                                                                      |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     19/49 (39%)  10/50 (20%)  20/50 (40%)  11/49 (22%) |11/50 (22%)  11/48 (23%)  7/50 (14%)   3/50 (6%)    |
|POLY-3 ADJUSTED (b)|     44.0%        24.3%        43.7%        24.4%       |24.6%        24.5%        15.0%        6.8%         |
|TERMINAL (d)       |     16/31 (52%)  7/27 (26%)   17/40 (43%)  10/38 (26%) |9/34 (27%)   10/37 (27%)  6/35 (17%)   2/32 (6%)    |
|FIRST INCIDENCE    |     516          573          492          673         |701          708          524          616          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.028N*    P=0.085N     P=0.302N     P=0.015N*   |P=0.014N*    P=0.505N     P=0.201N     P=0.030N*    |
|POLY 3             |     P=0.083N     P=0.042N*    P=0.573N     P=0.039N*   |P=0.009N**   P=0.592N     P=0.188N     P=0.020N*    |
|POLY 1.5           |     P=0.106N     P=0.038N*    P=0.564      P=0.047N*   |P=0.009N**   P=0.584      P=0.197N     P=0.020N*    |
|POLY 6             |     P=0.062N     P=0.049N*    P=0.523N     P=0.032N*   |P=0.009N**   P=0.569N     P=0.181N     P=0.020N*    |
|LOGISTIC REGRESSION|     P=0.078N     P=0.050N     P=0.555N     P=0.033N*   |P=0.010N*    P=0.520N     P=0.195N     P=0.024N*    |
|COCH-ARM / FISHERS |     P=0.151N     P=0.033N*    P=0.532      P=0.062N    |P=0.009N**   P=0.553      P=0.218N     P=0.020N*    |
|=================================================================================================================================|
       Date:  07/13/98                           EXPERIMENT: 05184 TEST: 06                                            Page 6
                     Statistical Analysis of Primary Tumors in Mice(B6C3F1)       -                   GLUTARALDEHYDE
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      62.5 PPB     125 PPB      250 PPB     |CONTROL      62.5 PPB     125 PPB      250 PPB      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Liver                                                                                                                            |
|     Hepatocellular Carcinoma                                                                                                    |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     15/49 (31%)  15/50 (30%)  12/50 (24%)  12/49 (24%) |4/50 (8%)    7/48 (15%)   5/50 (10%)   4/50 (8%)    |
|POLY-3 ADJUSTED (b)|     32.6%        33.8%        25.5%        25.6%       |8.9%         15.3%        10.8%        9.0%         |
|TERMINAL (d)       |     3/31 (10%)   4/27 (15%)   8/40 (20%)   6/38 (16%)  |2/34 (6%)    3/37 (8%)    4/35 (11%)   1/32 (3%)    |
|FIRST INCIDENCE    |     498          517          492          558         |657          551          672          401          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.129N     P=0.463      P=0.213N     P=0.232N    |P=0.480N     P=0.318      P=0.523      P=0.623      |
|POLY 3             |     P=0.209N     P=0.543      P=0.300N     P=0.305N    |P=0.441N     P=0.268      P=0.514      P=0.637      |
|POLY 1.5           |     P=0.223N     P=0.570      P=0.303N     P=0.313N    |P=0.433N     P=0.258      P=0.511      P=0.642      |
|POLY 6             |     P=0.196N     P=0.510      P=0.297N     P=0.299N    |P=0.454N     P=0.283      P=0.515      P=0.630      |
|LOGISTIC REGRESSION|     P=0.340N     P=0.472N     P=0.338N     P=0.421N    |P=0.418N     P=0.227      P=0.512      P=0.640N     |
|COCH-ARM / FISHERS |     P=0.245N     P=0.560N     P=0.304N     P=0.326N    |P=0.427N     P=0.239      P=0.500      P=0.643N     |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      62.5 PPB     125 PPB      250 PPB     |CONTROL      62.5 PPB     125 PPB      250 PPB      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Liver                                                                                                                            |
|     Hepatocellular Carcinoma or Hepatocellular Adenoma                                                                          |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     32/49 (65%)  24/50 (48%)  26/50 (52%)  21/49 (43%) |14/50 (28%)  17/48 (35%)  11/50 (22%)  7/50 (14%)   |
|POLY-3 ADJUSTED (b)|     68.6%        53.1%        55.2%        44.6%       |30.9%        37.2%        23.5%        15.6%        |
|TERMINAL (d)       |     19/31 (61%)  11/27 (41%)  21/40 (53%)  14/38 (37%) |10/34 (29%)  13/37 (35%)  9/35 (26%)   3/32 (9%)    |
|FIRST INCIDENCE    |     498          517          492          558         |657          551          524          401          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.006N**   P=0.275N     P=0.035N*    P=0.010N*   |P=0.043N*    P=0.442      P=0.297N     P=0.101N     |
|POLY 3             |     P=0.018N*    P=0.091N     P=0.128N     P=0.014N*   |P=0.021N*    P=0.342      P=0.285N     P=0.067N     |
|POLY 1.5           |     P=0.023N*    P=0.077N     P=0.128N     P=0.016N*   |P=0.021N*    P=0.321      P=0.295N     P=0.066N     |
|POLY 6             |     P=0.015N*    P=0.108N     P=0.127N     P=0.013N*   |P=0.023N*    P=0.369      P=0.279N     P=0.068N     |
|LOGISTIC REGRESSION|     P=0.030N*    P=0.065N     P=0.120N     P=0.022N*   |P=0.024N*    P=0.339      P=0.295N     P=0.072N     |
|COCH-ARM / FISHERS |     P=0.033N*    P=0.062N     P=0.127N     P=0.021N*   |P=0.022N*    P=0.284      P=0.322N     P=0.070N     |
|=================================================================================================================================|
       Date:  07/13/98                           EXPERIMENT: 05184 TEST: 06                                            Page 7
                     Statistical Analysis of Primary Tumors in Mice(B6C3F1)       -                   GLUTARALDEHYDE
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      62.5 PPB     125 PPB      250 PPB     |CONTROL      62.5 PPB     125 PPB      250 PPB      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Liver                                                                                                                            |
|     Hepatocellular Carcinoma, Hepatocellular Adenoma,                                                                           |
|     or Hepatoblastoma                                                                                                           |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     32/49 (65%)  24/50 (48%)  26/50 (52%)  21/49 (43%) |14/50 (28%)  17/48 (35%)  11/50 (22%)  7/50 (14%)   |
|POLY-3 ADJUSTED (b)|     68.6%        53.1%        55.2%        44.6%       |30.9%        37.2%        23.5%        15.6%        |
|TERMINAL (d)       |     19/31 (61%)  11/27 (41%)  21/40 (53%)  14/38 (37%) |10/34 (29%)  13/37 (35%)  9/35 (26%)   3/32 (9%)    |
|FIRST INCIDENCE    |     498          517          492          558         |657          551          524          401          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.006N**   P=0.275N     P=0.035N*    P=0.010N*   |P=0.043N*    P=0.442      P=0.297N     P=0.101N     |
|POLY 3             |     P=0.018N*    P=0.091N     P=0.128N     P=0.014N*   |P=0.021N*    P=0.342      P=0.285N     P=0.067N     |
|POLY 1.5           |     P=0.023N*    P=0.077N     P=0.128N     P=0.016N*   |P=0.021N*    P=0.321      P=0.295N     P=0.066N     |
|POLY 6             |     P=0.015N*    P=0.108N     P=0.127N     P=0.013N*   |P=0.023N*    P=0.369      P=0.279N     P=0.068N     |
|LOGISTIC REGRESSION|     P=0.030N*    P=0.065N     P=0.120N     P=0.022N*   |P=0.024N*    P=0.339      P=0.295N     P=0.072N     |
|COCH-ARM / FISHERS |     P=0.033N*    P=0.062N     P=0.127N     P=0.021N*   |P=0.022N*    P=0.284      P=0.322N     P=0.070N     |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      62.5 PPB     125 PPB      250 PPB     |CONTROL      62.5 PPB     125 PPB      250 PPB      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Lung                                                                                                                             |
|     Alveolar/Bronchiolar Adenoma                                                                                                |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     8/48 (17%)   10/50 (20%)  9/50 (18%)   7/50 (14%)  |2/50 (4%)    4/49 (8%)    2/50 (4%)    2/50 (4%)    |
|POLY-3 ADJUSTED (b)|     19.0%        24.3%        19.7%        15.2%       |4.5%         8.7%         4.3%         4.6%         |
|TERMINAL (d)       |     7/31 (23%)   7/27 (26%)   6/40 (15%)   5/38 (13%)  |2/34 (6%)    3/37 (8%)    0/35 (0%)    2/32 (6%)    |
|FIRST INCIDENCE    |     573          517          516          628         |735 (T)      463          702          735 (T)      |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.189N     P=0.291      P=0.512N     P=0.348N    |P=0.491N     P=0.372      P=0.678N     P=0.674      |
|POLY 3             |     P=0.283N     P=0.371      P=0.574      P=0.427N    |P=0.464N     P=0.350      P=0.682N     P=0.686      |
|POLY 1.5           |     P=0.309N     P=0.396      P=0.554      P=0.443N    |P=0.459N     P=0.342      P=0.685N     P=0.690      |
|POLY 6             |     P=0.253N     P=0.345      P=0.606      P=0.407N    |P=0.469N     P=0.361      P=0.678N     P=0.683      |
|LOGISTIC REGRESSION|     P=0.298N     P=0.364      P=0.555      P=0.431N    |P=0.452N     P=0.313      P=0.686N     P=0.674      |
|COCH-ARM / FISHERS |     P=0.346N     P=0.435      P=0.537      P=0.465N    |P=0.453N     P=0.329      P=0.691N     P=0.691N     |
|=================================================================================================================================|
       Date:  07/13/98                           EXPERIMENT: 05184 TEST: 06                                            Page 8
                     Statistical Analysis of Primary Tumors in Mice(B6C3F1)       -                   GLUTARALDEHYDE
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      62.5 PPB     125 PPB      250 PPB     |CONTROL      62.5 PPB     125 PPB      250 PPB      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Lung                                                                                                                             |
|     Alveolar/Bronchiolar Carcinoma                                                                                              |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     10/48 (21%)  6/50 (12%)   7/50 (14%)   7/50 (14%)  |1/50 (2%)    4/49 (8%)    5/50 (10%)   2/50 (4%)    |
|POLY-3 ADJUSTED (b)|     23.3%        14.3%        15.1%        15.3%       |2.2%         8.9%         10.8%        4.6%         |
|TERMINAL (d)       |     7/31 (23%)   3/27 (11%)   5/40 (13%)   5/38 (13%)  |1/34 (3%)    3/37 (8%)    4/35 (11%)   2/32 (6%)    |
|FIRST INCIDENCE    |     454          364          470          673         |735 (T)      728          635          735 (T)      |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.179N     P=0.288N     P=0.172N     P=0.184N    |P=0.453      P=0.207      P=0.113      P=0.479      |
|POLY 3             |     P=0.253N     P=0.216N     P=0.236N     P=0.245N    |P=0.482      P=0.182      P=0.110      P=0.492      |
|POLY 1.5           |     P=0.271N     P=0.201N     P=0.252N     P=0.255N    |P=0.493      P=0.179      P=0.107      P=0.496      |
|POLY 6             |     P=0.232N     P=0.236N     P=0.214N     P=0.234N    |P=0.471      P=0.188      P=0.112      P=0.489      |
|LOGISTIC REGRESSION|     P=0.320N     P=0.155N     P=0.272N     P=0.252N    |P=0.478      P=0.203      P=0.109      P=0.479      |
|COCH-ARM / FISHERS |     P=0.294N     P=0.182N     P=0.266N     P=0.266N    |P=0.504      P=0.175      P=0.102      P=0.500      |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      62.5 PPB     125 PPB      250 PPB     |CONTROL      62.5 PPB     125 PPB      250 PPB      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Lung                                                                                                                             |
|     Alveolar/Bronchiolar Carcinoma or Alveolar/Bronchiolar                                                                      |
|     Adenoma                                                                                                                     |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     18/48 (38%)  15/50 (30%)  15/50 (30%)  14/50 (28%) |3/50 (6%)    8/49 (16%)   7/50 (14%)   4/50 (8%)    |
|POLY-3 ADJUSTED (b)|     41.5%        34.8%        31.8%        30.3%       |6.7%         17.4%        15.0%        9.2%         |
|TERMINAL (d)       |     14/31 (45%)  9/27 (33%)   10/40 (25%)  10/38 (26%) |3/34 (9%)    6/37 (16%)   4/35 (11%)   4/32 (13%)   |
|FIRST INCIDENCE    |     454          364          470          628         |735 (T)      463          635          735 (T)      |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.082N     P=0.494N     P=0.139N     P=0.114N    |P=0.533      P=0.129      P=0.179      P=0.466      |
|POLY 3             |     P=0.165N     P=0.338N     P=0.230N     P=0.186N    |P=0.549N     P=0.107      P=0.174      P=0.488      |
|POLY 1.5           |     P=0.186N     P=0.315N     P=0.256N     P=0.199N    |P=0.538N     P=0.102      P=0.169      P=0.494      |
|POLY 6             |     P=0.140N     P=0.365N     P=0.194N     P=0.168N    |P=0.558      P=0.114      P=0.181      P=0.482      |
|LOGISTIC REGRESSION|     P=0.209N     P=0.298N     P=0.284N     P=0.187N    |P=0.541N     P=0.097      P=0.169      P=0.466      |
|COCH-ARM / FISHERS |     P=0.215N     P=0.284N     P=0.284N     P=0.216N    |P=0.525N     P=0.094      P=0.159      P=0.500      |
|=================================================================================================================================|
       Date:  07/13/98                           EXPERIMENT: 05184 TEST: 06                                            Page 9
                     Statistical Analysis of Primary Tumors in Mice(B6C3F1)       -                   GLUTARALDEHYDE
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      62.5 PPB     125 PPB      250 PPB     |CONTROL      62.5 PPB     125 PPB      250 PPB      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Mammary Gland                                                                                                                    |
|     Carcinoma                                                                                                                   |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     0/50 (0%)    0/50 (0%)    0/50 (0%)    0/50 (0%)   |3/50 (6%)    0/50 (0%)    3/50 (6%)    0/50 (0%)    |
|POLY-3 ADJUSTED (b)|     0.0%         0.0%         0.0%         0.0%        |6.7%         0.0%         6.5%         0.0%         |
|TERMINAL (d)       |     0/31 (0%)    0/27 (0%)    0/40 (0%)    0/38 (0%)   |2/34 (6%)    0/37 (0%)    1/35 (3%)    0/32 (0%)    |
|FIRST INCIDENCE    |     ---          ---          ---          ---         |664          ---          704          ---          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     (e)          (e)          (e)          (e)         |P=0.176N     P=0.111N     P=0.642N     P=0.133N     |
|POLY 3             |     (e)          (e)          (e)          (e)         |P=0.171N     P=0.116N     P=0.650N     P=0.124N     |
|POLY 1.5           |     (e)          (e)          (e)          (e)         |P=0.167N     P=0.117N     P=0.653N     P=0.121N     |
|POLY 6             |     (e)          (e)          (e)          (e)         |P=0.176N     P=0.114N     P=0.648N     P=0.126N     |
|LOGISTIC REGRESSION|     (e)          (e)          (e)          (e)         |P=0.166N     P=0.118N     P=0.653N     P=0.123N     |
|COCH-ARM / FISHERS |     (e)          (e)          (e)          (e)         |P=0.163N     P=0.121N     P=0.661N     P=0.121N     |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      62.5 PPB     125 PPB      250 PPB     |CONTROL      62.5 PPB     125 PPB      250 PPB      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Ovary                                                                                                                            |
|     Cystadenoma                                                                                                                 |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |                                                        |1/49 (2%)    1/47 (2%)    1/49 (2%)    2/50 (4%)    |
|POLY-3 ADJUSTED (b)|                                                        |2.3%         2.3%         2.2%         4.6%         |
|TERMINAL (d)       |                                                        |1/34 (3%)    1/36 (3%)    1/35 (3%)    2/32 (6%)    |
|FIRST INCIDENCE    |                                                        |735 (T)      735 (T)      735 (T)      735 (T)      |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |                                                        |P=0.324      P=0.749N     P=0.755N     P=0.479      |
|POLY 3             |                                                        |P=0.352      P=0.760N     P=0.753N     P=0.499      |
|POLY 1.5           |                                                        |P=0.357      P=0.758      P=0.755N     P=0.503      |
|POLY 6             |                                                        |P=0.346      P=0.755N     P=0.752N     P=0.495      |
|LOGISTIC REGRESSION|                                                        |P=0.324      P=0.749N     P=0.755N     P=0.479      |
|COCH-ARM / FISHERS |                                                        |P=0.363      P=0.742      P=0.753N     P=0.508      |
|=================================================================================================================================|
       Date:  07/13/98                           EXPERIMENT: 05184 TEST: 06                                            Page 10
                     Statistical Analysis of Primary Tumors in Mice(B6C3F1)       -                   GLUTARALDEHYDE
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      62.5 PPB     125 PPB      250 PPB     |CONTROL      62.5 PPB     125 PPB      250 PPB      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Ovary                                                                                                                            |
|     Luteoma                                                                                                                     |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |                                                        |2/49 (4%)    0/47 (0%)    0/49 (0%)    0/50 (0%)    |
|POLY-3 ADJUSTED (b)|                                                        |4.6%         0.0%         0.0%         0.0%         |
|TERMINAL (d)       |                                                        |1/34 (3%)    0/36 (0%)    0/35 (0%)    0/32 (0%)    |
|FIRST INCIDENCE    |                                                        |702          ---          ---          ---          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |                                                        |P=0.118N     P=0.220N     P=0.231N     P=0.249N     |
|POLY 3             |                                                        |P=0.113N     P=0.237N     P=0.231N     P=0.238N     |
|POLY 1.5           |                                                        |P=0.113N     P=0.240N     P=0.232N     P=0.235N     |
|POLY 6             |                                                        |P=0.114N     P=0.233N     P=0.229N     P=0.241N     |
|LOGISTIC REGRESSION|                                                        |P=0.113N     P=0.238N     P=0.231N     P=0.238N     |
|COCH-ARM / FISHERS |                                                        |P=0.113N     P=0.258N     P=0.247N     P=0.242N     |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      62.5 PPB     125 PPB      250 PPB     |CONTROL      62.5 PPB     125 PPB      250 PPB      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Pituitary Gland: Pars Distalis or Unspecified Site                                                                               |
|     Adenoma                                                                                                                     |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     1/46 (2%)    0/47 (0%)    0/48 (0%)    0/47 (0%)   |20/49 (41%)  16/49 (33%)  20/49 (41%)  16/50 (32%)  |
|POLY-3 ADJUSTED (b)|     2.5%         0.0%         0.0%         0.0%        |44.9%        35.4%        43.0%        35.2%        |
|TERMINAL (d)       |     1/30 (3%)    0/27 (0%)    0/38 (0%)    0/37 (0%)   |17/34 (50%)  15/37 (41%)  16/35 (46%)  11/32 (34%)  |
|FIRST INCIDENCE    |     733 (T)      ---          ---          ---         |616          714          502          552          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.273N     P=0.521N     P=0.453N     P=0.458N    |P=0.423N     P=0.168N     P=0.529N     P=0.343N     |
|POLY 3             |     P=0.302N     P=0.509N     P=0.484N     P=0.481N    |P=0.277N     P=0.240N     P=0.511N     P=0.233N     |
|POLY 1.5           |     P=0.303N     P=0.504N     P=0.488N     P=0.486N    |P=0.277N     P=0.247N     P=0.533N     P=0.234N     |
|POLY 6             |     P=0.301N     P=0.514N     P=0.477N     P=0.474N    |P=0.274N     P=0.229N     P=0.489N     P=0.228N     |
|LOGISTIC REGRESSION|     P=0.273N     (e)          (e)          (e)         |P=0.326N     P=0.189N     P=0.537N     P=0.270N     |
|COCH-ARM / FISHERS |     P=0.302N     P=0.495N     P=0.489N     P=0.495N    |P=0.281N     P=0.265N     P=0.581N     P=0.241N     |
|=================================================================================================================================|
       Date:  07/13/98                           EXPERIMENT: 05184 TEST: 06                                            Page 11
                     Statistical Analysis of Primary Tumors in Mice(B6C3F1)       -                   GLUTARALDEHYDE
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      62.5 PPB     125 PPB      250 PPB     |CONTROL      62.5 PPB     125 PPB      250 PPB      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Pituitary Gland: Pars Distalis or Unspecified Site                                                                               |
|     Carcinoma or Adenoma                                                                                                        |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     1/46 (2%)    0/47 (0%)    0/48 (0%)    0/47 (0%)   |21/49 (43%)  16/49 (33%)  20/49 (41%)  16/50 (32%)  |
|POLY-3 ADJUSTED (b)|     2.5%         0.0%         0.0%         0.0%        |46.8%        35.4%        43.0%        35.2%        |
|TERMINAL (d)       |     1/30 (3%)    0/27 (0%)    0/38 (0%)    0/37 (0%)   |17/34 (50%)  15/37 (41%)  16/35 (46%)  11/32 (34%)  |
|FIRST INCIDENCE    |     733 (T)      ---          ---          ---         |616          714          502          552          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.273N     P=0.521N     P=0.453N     P=0.458N    |P=0.358N     P=0.124N     P=0.447N     P=0.277N     |
|POLY 3             |     P=0.302N     P=0.509N     P=0.484N     P=0.481N    |P=0.225N     P=0.185N     P=0.436N     P=0.179N     |
|POLY 1.5           |     P=0.303N     P=0.504N     P=0.488N     P=0.486N    |P=0.224N     P=0.189N     P=0.454N     P=0.177N     |
|POLY 6             |     P=0.301N     P=0.514N     P=0.477N     P=0.474N    |P=0.226N     P=0.179N     P=0.420N     P=0.179N     |
|LOGISTIC REGRESSION|     P=0.273N     (e)          (e)          (e)         |P=0.262N     P=0.148N     P=0.456N     P=0.203N     |
|COCH-ARM / FISHERS |     P=0.302N     P=0.495N     P=0.489N     P=0.495N    |P=0.225N     P=0.202N     P=0.500N     P=0.182N     |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      62.5 PPB     125 PPB      250 PPB     |CONTROL      62.5 PPB     125 PPB      250 PPB      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Skin                                                                                                                             |
|     Fibroma, Fibrosarcoma, Sarcoma, Myxoma, Myxosarcoma,                                                                        |
|     or Fibrous Histiocytoma                                                                                                     |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     1/50 (2%)    2/50 (4%)    0/50 (0%)    0/50 (0%)   |3/50 (6%)    1/50 (2%)    3/50 (6%)    3/50 (6%)    |
|POLY-3 ADJUSTED (b)|     2.3%         4.9%         0.0%         0.0%        |6.7%         2.2%         6.5%         6.8%         |
|TERMINAL (d)       |     0/31 (0%)    0/27 (0%)    0/40 (0%)    0/38 (0%)   |1/34 (3%)    1/37 (3%)    2/35 (6%)    2/32 (6%)    |
|FIRST INCIDENCE    |     712          476          ---          ---         |681          735 (T)      715          660          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.170N     P=0.464      P=0.458N     P=0.473N    |P=0.424      P=0.278N     P=0.641N     P=0.640      |
|POLY 3             |     P=0.181N     P=0.485      P=0.490N     P=0.488N    |P=0.442      P=0.300N     P=0.652N     P=0.652      |
|POLY 1.5           |     P=0.184N     P=0.491      P=0.495N     P=0.493N    |P=0.448      P=0.301N     P=0.654N     P=0.657      |
|POLY 6             |     P=0.178N     P=0.478      P=0.482N     P=0.482N    |P=0.434      P=0.297N     P=0.652N     P=0.646      |
|LOGISTIC REGRESSION|     P=0.209N     P=0.547      P=0.491N     P=0.489N    |P=0.445      P=0.300N     P=0.652N     P=0.658      |
|COCH-ARM / FISHERS |     P=0.188N     P=0.500      P=0.500N     P=0.500N    |P=0.456      P=0.309N     P=0.661N     P=0.661N     |
|=================================================================================================================================|
       Date:  07/13/98                           EXPERIMENT: 05184 TEST: 06                                            Page 12
                     Statistical Analysis of Primary Tumors in Mice(B6C3F1)       -                   GLUTARALDEHYDE
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      62.5 PPB     125 PPB      250 PPB     |CONTROL      62.5 PPB     125 PPB      250 PPB      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Skin                                                                                                                             |
|     Fibrosarcoma                                                                                                                |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     1/50 (2%)    1/50 (2%)    0/50 (0%)    0/50 (0%)   |1/50 (2%)    1/50 (2%)    3/50 (6%)    0/50 (0%)    |
|POLY-3 ADJUSTED (b)|     2.3%         2.5%         0.0%         0.0%        |2.2%         2.2%         6.5%         0.0%         |
|TERMINAL (d)       |     0/31 (0%)    0/27 (0%)    0/40 (0%)    0/38 (0%)   |1/34 (3%)    1/37 (3%)    2/35 (6%)    0/32 (0%)    |
|FIRST INCIDENCE    |     712          476          ---          ---         |735 (T)      735 (T)      715          ---          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.219N     P=0.740      P=0.458N     P=0.473N    |P=0.432N     P=0.743N     P=0.322      P=0.512N     |
|POLY 3             |     P=0.231N     P=0.749      P=0.490N     P=0.488N    |P=0.423N     P=0.756N     P=0.316      P=0.504N     |
|POLY 1.5           |     P=0.234N     P=0.754      P=0.495N     P=0.493N    |P=0.417N     P=0.757N     P=0.313      P=0.502N     |
|POLY 6             |     P=0.229N     P=0.744      P=0.482N     P=0.482N    |P=0.430N     P=0.753N     P=0.319      P=0.507N     |
|LOGISTIC REGRESSION|     P=0.257N     P=0.729N     P=0.491N     P=0.489N    |P=0.425N     P=0.743N     P=0.317      (e)          |
|COCH-ARM / FISHERS |     P=0.236N     P=0.753N     P=0.500N     P=0.500N    |P=0.409N     P=0.753N     P=0.309      P=0.500N     |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      62.5 PPB     125 PPB      250 PPB     |CONTROL      62.5 PPB     125 PPB      250 PPB      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Skin                                                                                                                             |
|     Fibrosarcoma, Sarcoma, Myxosarcoma, or Fibrous Histiocytoma                                                                 |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     1/50 (2%)    2/50 (4%)    0/50 (0%)    0/50 (0%)   |3/50 (6%)    1/50 (2%)    3/50 (6%)    3/50 (6%)    |
|POLY-3 ADJUSTED (b)|     2.3%         4.9%         0.0%         0.0%        |6.7%         2.2%         6.5%         6.8%         |
|TERMINAL (d)       |     0/31 (0%)    0/27 (0%)    0/40 (0%)    0/38 (0%)   |1/34 (3%)    1/37 (3%)    2/35 (6%)    2/32 (6%)    |
|FIRST INCIDENCE    |     712          476          ---          ---         |681          735 (T)      715          660          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.170N     P=0.464      P=0.458N     P=0.473N    |P=0.424      P=0.278N     P=0.641N     P=0.640      |
|POLY 3             |     P=0.181N     P=0.485      P=0.490N     P=0.488N    |P=0.442      P=0.300N     P=0.652N     P=0.652      |
|POLY 1.5           |     P=0.184N     P=0.491      P=0.495N     P=0.493N    |P=0.448      P=0.301N     P=0.654N     P=0.657      |
|POLY 6             |     P=0.178N     P=0.478      P=0.482N     P=0.482N    |P=0.434      P=0.297N     P=0.652N     P=0.646      |
|LOGISTIC REGRESSION|     P=0.209N     P=0.547      P=0.491N     P=0.489N    |P=0.445      P=0.300N     P=0.652N     P=0.658      |
|COCH-ARM / FISHERS |     P=0.188N     P=0.500      P=0.500N     P=0.500N    |P=0.456      P=0.309N     P=0.661N     P=0.661N     |
|=================================================================================================================================|
       Date:  07/13/98                           EXPERIMENT: 05184 TEST: 06                                            Page 13
                     Statistical Analysis of Primary Tumors in Mice(B6C3F1)       -                   GLUTARALDEHYDE
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      62.5 PPB     125 PPB      250 PPB     |CONTROL      62.5 PPB     125 PPB      250 PPB      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Skin                                                                                                                             |
|     Sarcoma                                                                                                                     |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     0/50 (0%)    1/50 (2%)    0/50 (0%)    0/50 (0%)   |2/50 (4%)    0/50 (0%)    0/50 (0%)    3/50 (6%)    |
|POLY-3 ADJUSTED (b)|     0.0%         2.5%         0.0%         0.0%        |4.4%         0.0%         0.0%         6.8%         |
|TERMINAL (d)       |     0/31 (0%)    0/27 (0%)    0/40 (0%)    0/38 (0%)   |0/34 (0%)    0/37 (0%)    0/35 (0%)    2/32 (6%)    |
|FIRST INCIDENCE    |     ---          647          ---          ---         |681          ---          ---          660          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.544N     P=0.473      (e)          (e)         |P=0.228      P=0.221N     P=0.232N     P=0.482      |
|POLY 3             |     P=0.569N     P=0.488      (e)          (e)         |P=0.240      P=0.234N     P=0.232N     P=0.489      |
|POLY 1.5           |     P=0.568N     P=0.493      (e)          (e)         |P=0.242      P=0.235N     P=0.233N     P=0.495      |
|POLY 6             |     P=0.570N     P=0.483      (e)          (e)         |P=0.237      P=0.232N     P=0.233N     P=0.484      |
|LOGISTIC REGRESSION|     P=0.585N     P=0.512      (e)          (e)         |P=0.245      P=0.241N     P=0.243N     P=0.498      |
|COCH-ARM / FISHERS |     P=0.567N     P=0.500      (e)          (e)         |P=0.245      P=0.247N     P=0.247N     P=0.500      |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      62.5 PPB     125 PPB      250 PPB     |CONTROL      62.5 PPB     125 PPB      250 PPB      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Spleen                                                                                                                           |
|     Hemangiosarcoma                                                                                                             |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     1/48 (2%)    1/48 (2%)    1/50 (2%)    1/48 (2%)   |1/50 (2%)    3/48 (6%)    1/48 (2%)    1/49 (2%)    |
|POLY-3 ADJUSTED (b)|     2.4%         2.6%         2.2%         2.2%        |2.2%         6.6%         2.2%         2.3%         |
|TERMINAL (d)       |     0/31 (0%)    0/27 (0%)    1/40 (3%)    0/38 (0%)   |1/34 (3%)    2/37 (5%)    0/35 (0%)    1/32 (3%)    |
|FIRST INCIDENCE    |     516          685          733 (T)      663         |735 (T)      672          715          735 (T)      |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.589N     P=0.748      P=0.735N     P=0.750N    |P=0.468N     P=0.336      P=0.748N     P=0.748      |
|POLY 3             |     P=0.610N     P=0.743      P=0.747N     P=0.746N    |P=0.452N     P=0.309      P=0.760      P=0.753      |
|POLY 1.5           |     P=0.619N     P=0.750      P=0.750N     P=0.752N    |P=0.450N     P=0.302      P=0.757      P=0.754      |
|POLY 6             |     P=0.601N     P=0.736      P=0.740N     P=0.740N    |P=0.453N     P=0.319      P=0.757N     P=0.751      |
|LOGISTIC REGRESSION|     P=0.591      P=0.727N     P=0.753N     P=0.633     |P=0.459N     P=0.304      P=0.761N     P=0.748      |
|COCH-ARM / FISHERS |     P=0.633N     P=0.753N     P=0.742N     P=0.753N    |P=0.449N     P=0.293      P=0.742      P=0.747      |
|=================================================================================================================================|
       Date:  07/13/98                           EXPERIMENT: 05184 TEST: 06                                            Page 14
                     Statistical Analysis of Primary Tumors in Mice(B6C3F1)       -                   GLUTARALDEHYDE
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      62.5 PPB     125 PPB      250 PPB     |CONTROL      62.5 PPB     125 PPB      250 PPB      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Stomach, Forestomach                                                                                                             |
|     Squamous Cell Carcinoma or Papilloma Squamous                                                                               |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     0/50 (0%)    2/50 (4%)    0/50 (0%)    0/50 (0%)   |1/50 (2%)    1/50 (2%)    2/50 (4%)    0/50 (0%)    |
|POLY-3 ADJUSTED (b)|     0.0%         5.0%         0.0%         0.0%        |2.2%         2.2%         4.4%         0.0%         |
|TERMINAL (d)       |     0/31 (0%)    1/27 (4%)    0/40 (0%)    0/38 (0%)   |1/34 (3%)    1/37 (3%)    2/35 (6%)    0/32 (0%)    |
|FIRST INCIDENCE    |     ---          718          ---          ---         |735 (T)      735 (T)      735 (T)      ---          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.352N     P=0.214      (e)          (e)         |P=0.388N     P=0.743N     P=0.510      P=0.512N     |
|POLY 3             |     P=0.402N     P=0.222      (e)          (e)         |P=0.377N     P=0.756N     P=0.510      P=0.504N     |
|POLY 1.5           |     P=0.403N     P=0.228      (e)          (e)         |P=0.372N     P=0.757N     P=0.507      P=0.502N     |
|POLY 6             |     P=0.401N     P=0.216      (e)          (e)         |P=0.382N     P=0.753N     P=0.512      P=0.507N     |
|LOGISTIC REGRESSION|     P=0.373N     P=0.211      (e)          (e)         |P=0.388N     P=0.743N     P=0.510      (e)          |
|COCH-ARM / FISHERS |     P=0.405N     P=0.247      (e)          (e)         |P=0.366N     P=0.753N     P=0.500      P=0.500N     |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      62.5 PPB     125 PPB      250 PPB     |CONTROL      62.5 PPB     125 PPB      250 PPB      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Testes                                                                                                                           |
|     Adenoma                                                                                                                     |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     0/48 (0%)    1/50 (2%)    2/50 (4%)    2/50 (4%)   |                                                    |
|POLY-3 ADJUSTED (b)|     0.0%         2.5%         4.4%         4.4%        |                                                    |
|TERMINAL (d)       |     0/31 (0%)    0/27 (0%)    2/40 (5%)    1/38 (3%)   |                                                    |
|FIRST INCIDENCE    |     ---          640          733 (T)      651         |                                                    |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.216      P=0.484      P=0.296      P=0.273     |                                                    |
|POLY 3             |     P=0.190      P=0.493      P=0.254      P=0.259     |                                                    |
|POLY 1.5           |     P=0.180      P=0.499      P=0.250      P=0.254     |                                                    |
|POLY 6             |     P=0.202      P=0.487      P=0.263      P=0.265     |                                                    |
|LOGISTIC REGRESSION|     P=0.171      P=0.528      P=0.296      P=0.243     |                                                    |
|COCH-ARM / FISHERS |     P=0.166      P=0.510      P=0.258      P=0.258     |                                                    |
|=================================================================================================================================|
       Date:  07/13/98                           EXPERIMENT: 05184 TEST: 06                                            Page 15
                     Statistical Analysis of Primary Tumors in Mice(B6C3F1)       -                   GLUTARALDEHYDE
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      62.5 PPB     125 PPB      250 PPB     |CONTROL      62.5 PPB     125 PPB      250 PPB      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Thyroid Gland: Follicular Cell                                                                                                   |
|     Adenoma                                                                                                                     |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     1/48 (2%)    3/49 (6%)    2/49 (4%)    1/49 (2%)   |4/50 (8%)    0/48 (0%)    2/50 (4%)    3/50 (6%)    |
|POLY-3 ADJUSTED (b)|     2.4%         7.6%         4.5%         2.2%        |9.0%         0.0%         4.4%         6.9%         |
|TERMINAL (d)       |     1/31 (3%)    3/27 (11%)   2/39 (5%)    1/38 (3%)   |4/34 (12%)   0/37 (0%)    2/35 (6%)    3/32 (9%)    |
|FIRST INCIDENCE    |     733 (T)      733 (T)      733 (T)      733 (T)     |735 (T)      ---          735 (T)      735 (T)      |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.366N     P=0.256      P=0.580      P=0.716N    |P=0.531      P=0.053N     P=0.322N     P=0.534N     |
|POLY 3             |     P=0.439N     P=0.284      P=0.519      P=0.744N    |P=0.554      P=0.059N     P=0.324N     P=0.512N     |
|POLY 1.5           |     P=0.451N     P=0.295      P=0.512      P=0.749N    |P=0.563      P=0.062N     P=0.328N     P=0.506N     |
|POLY 6             |     P=0.426N     P=0.272      P=0.531      P=0.738N    |P=0.544      P=0.056N     P=0.321N     P=0.518N     |
|LOGISTIC REGRESSION|     P=0.366N     P=0.256      P=0.580      P=0.716N    |P=0.531      (e)          P=0.322N     P=0.534N     |
|COCH-ARM / FISHERS |     P=0.468N     P=0.316      P=0.508      P=0.747N    |P=0.575      P=0.064N     P=0.339N     P=0.500N     |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      62.5 PPB     125 PPB      250 PPB     |CONTROL      62.5 PPB     125 PPB      250 PPB      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Thyroid Gland: Follicular Cell                                                                                                   |
|     Carcinoma or Adenoma                                                                                                        |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     2/48 (4%)    3/49 (6%)    2/49 (4%)    1/49 (2%)   |4/50 (8%)    0/48 (0%)    2/50 (4%)    4/50 (8%)    |
|POLY-3 ADJUSTED (b)|     4.8%         7.6%         4.5%         2.2%        |9.0%         0.0%         4.4%         9.2%         |
|TERMINAL (d)       |     1/31 (3%)    3/27 (11%)   2/39 (5%)    1/38 (3%)   |4/34 (12%)   0/37 (0%)    2/35 (6%)    4/32 (13%)   |
|FIRST INCIDENCE    |     716          733 (T)      733 (T)      733 (T)     |735 (T)      ---          735 (T)      735 (T)      |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.219N     P=0.438      P=0.610N     P=0.434N    |P=0.328      P=0.053N     P=0.322N     P=0.612      |
|POLY 3             |     P=0.280N     P=0.472      P=0.675N     P=0.475N    |P=0.357      P=0.059N     P=0.324N     P=0.631      |
|POLY 1.5           |     P=0.291N     P=0.487      P=0.681N     P=0.482N    |P=0.366      P=0.062N     P=0.328N     P=0.637      |
|POLY 6             |     P=0.268N     P=0.456      P=0.663N     P=0.465N    |P=0.347      P=0.056N     P=0.321N     P=0.626      |
|LOGISTIC REGRESSION|     P=0.238N     P=0.442      P=0.650N     P=0.457N    |P=0.328      (e)          P=0.322N     P=0.612      |
|COCH-ARM / FISHERS |     P=0.306N     P=0.510      P=0.684N     P=0.492N    |P=0.378      P=0.064N     P=0.339N     P=0.643N     |
|=================================================================================================================================|
       Date:  07/13/98                           EXPERIMENT: 05184 TEST: 06                                            Page 16
                     Statistical Analysis of Primary Tumors in Mice(B6C3F1)       -                   GLUTARALDEHYDE
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      62.5 PPB     125 PPB      250 PPB     |CONTROL      62.5 PPB     125 PPB      250 PPB      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Uterus                                                                                                                           |
|     Carcinoma                                                                                                                   |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |                                                        |0/50 (0%)    1/50 (2%)    2/50 (4%)    2/50 (4%)    |
|POLY-3 ADJUSTED (b)|                                                        |0.0%         2.2%         4.3%         4.6%         |
|TERMINAL (d)       |                                                        |0/34 (0%)    0/37 (0%)    1/35 (3%)    2/32 (6%)    |
|FIRST INCIDENCE    |                                                        |---          714          570          735 (T)      |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |                                                        |P=0.144      P=0.522      P=0.248      P=0.225      |
|POLY 3             |                                                        |P=0.152      P=0.505      P=0.246      P=0.232      |
|POLY 1.5           |                                                        |P=0.156      P=0.503      P=0.244      P=0.235      |
|POLY 6             |                                                        |P=0.148      P=0.508      P=0.249      P=0.230      |
|LOGISTIC REGRESSION|                                                        |P=0.162      P=0.503      P=0.194      P=0.225      |
|COCH-ARM / FISHERS |                                                        |P=0.160      P=0.500      P=0.247      P=0.247      |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      62.5 PPB     125 PPB      250 PPB     |CONTROL      62.5 PPB     125 PPB      250 PPB      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Uterus                                                                                                                           |
|     Leiomyoma                                                                                                                   |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |                                                        |0/50 (0%)    0/50 (0%)    2/50 (4%)    1/50 (2%)    |
|POLY-3 ADJUSTED (b)|                                                        |0.0%         0.0%         4.4%         2.3%         |
|TERMINAL (d)       |                                                        |0/34 (0%)    0/37 (0%)    2/35 (6%)    1/32 (3%)    |
|FIRST INCIDENCE    |                                                        |---          ---          735 (T)      735 (T)      |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |                                                        |P=0.224      (e)          P=0.245      P=0.488      |
|POLY 3             |                                                        |P=0.233      (e)          P=0.243      P=0.496      |
|POLY 1.5           |                                                        |P=0.239      (e)          P=0.242      P=0.498      |
|POLY 6             |                                                        |P=0.227      (e)          P=0.245      P=0.493      |
|LOGISTIC REGRESSION|                                                        |(e)          (e)          P=0.245      P=0.488      |
|COCH-ARM / FISHERS |                                                        |P=0.246      (e)          P=0.247      P=0.500      |
|=================================================================================================================================|
       Date:  07/13/98                           EXPERIMENT: 05184 TEST: 06                                            Page 17
                     Statistical Analysis of Primary Tumors in Mice(B6C3F1)       -                   GLUTARALDEHYDE
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      62.5 PPB     125 PPB      250 PPB     |CONTROL      62.5 PPB     125 PPB      250 PPB      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Uterus                                                                                                                           |
|     Polyp Stromal                                                                                                               |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |                                                        |3/50 (6%)    4/50 (8%)    3/50 (6%)    0/50 (0%)    |
|POLY-3 ADJUSTED (b)|                                                        |6.7%         8.6%         6.5%         0.0%         |
|TERMINAL (d)       |                                                        |3/34 (9%)    3/37 (8%)    3/35 (9%)    0/32 (0%)    |
|FIRST INCIDENCE    |                                                        |735 (T)      527          735 (T)      ---          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |                                                        |P=0.087N     P=0.539      P=0.651N     P=0.131N     |
|POLY 3             |                                                        |P=0.082N     P=0.520      P=0.649N     P=0.122N     |
|POLY 1.5           |                                                        |P=0.079N     P=0.513      P=0.652N     P=0.121N     |
|POLY 6             |                                                        |P=0.084N     P=0.531      P=0.647N     P=0.124N     |
|LOGISTIC REGRESSION|                                                        |P=0.079N     P=0.502      P=0.651N     (e)          |
|COCH-ARM / FISHERS |                                                        |P=0.077N     P=0.500      P=0.661N     P=0.121N     |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      62.5 PPB     125 PPB      250 PPB     |CONTROL      62.5 PPB     125 PPB      250 PPB      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|All Organs                                                                                                                       |
|     Hemangiosarcoma                                                                                                             |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     3/50 (6%)    1/50 (2%)    4/50 (8%)    2/50 (4%)   |3/50 (6%)    6/50 (12%)   2/50 (4%)    1/50 (2%)    |
|POLY-3 ADJUSTED (b)|     6.9%         2.5%         8.9%         4.4%        |6.7%         13.1%        4.3%         2.3%         |
|TERMINAL (d)       |     1/31 (3%)    0/27 (0%)    4/40 (10%)   1/38 (3%)   |2/34 (6%)    5/37 (14%)   0/35 (0%)    1/32 (3%)    |
|FIRST INCIDENCE    |     516          685          733 (T)      663         |701          672          687          735 (T)      |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.438N     P=0.342N     P=0.612      P=0.440N    |P=0.131N     P=0.288      P=0.481N     P=0.325N     |
|POLY 3             |     P=0.495N     P=0.334N     P=0.519      P=0.476N    |P=0.117N     P=0.254      P=0.486N     P=0.314N     |
|POLY 1.5           |     P=0.515N     P=0.323N     P=0.508      P=0.486N    |P=0.115N     P=0.251      P=0.490N     P=0.310N     |
|POLY 6             |     P=0.471N     P=0.347N     P=0.538      P=0.464N    |P=0.120N     P=0.261      P=0.482N     P=0.319N     |
|LOGISTIC REGRESSION|     P=0.528N     P=0.293N     P=0.507      P=0.525N    |P=0.119N     P=0.258      P=0.491N     P=0.317N     |
|COCH-ARM / FISHERS |     P=0.544N     P=0.309N     P=0.500      P=0.500N    |P=0.114N     P=0.243      P=0.500N     P=0.309N     |
|=================================================================================================================================|
       Date:  07/13/98                           EXPERIMENT: 05184 TEST: 06                                            Page 18
                     Statistical Analysis of Primary Tumors in Mice(B6C3F1)       -                   GLUTARALDEHYDE
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      62.5 PPB     125 PPB      250 PPB     |CONTROL      62.5 PPB     125 PPB      250 PPB      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|All Organs                                                                                                                       |
|     Hemangiosarcoma or Hemangioma                                                                                               |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     3/50 (6%)    1/50 (2%)    4/50 (8%)    2/50 (4%)   |3/50 (6%)    7/50 (14%)   2/50 (4%)    1/50 (2%)    |
|POLY-3 ADJUSTED (b)|     6.9%         2.5%         8.9%         4.4%        |6.7%         15.2%        4.3%         2.3%         |
|TERMINAL (d)       |     1/31 (3%)    0/27 (0%)    4/40 (10%)   1/38 (3%)   |2/34 (6%)    6/37 (16%)   0/35 (0%)    1/32 (3%)    |
|FIRST INCIDENCE    |     516          685          733 (T)      663         |701          672          687          735 (T)      |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.438N     P=0.342N     P=0.612      P=0.440N    |P=0.112N     P=0.197      P=0.481N     P=0.325N     |
|POLY 3             |     P=0.495N     P=0.334N     P=0.519      P=0.476N    |P=0.097N     P=0.167      P=0.486N     P=0.314N     |
|POLY 1.5           |     P=0.515N     P=0.323N     P=0.508      P=0.486N    |P=0.095N     P=0.164      P=0.490N     P=0.310N     |
|POLY 6             |     P=0.471N     P=0.347N     P=0.538      P=0.464N    |P=0.100N     P=0.173      P=0.482N     P=0.319N     |
|LOGISTIC REGRESSION|     P=0.528N     P=0.293N     P=0.507      P=0.525N    |P=0.101N     P=0.172      P=0.491N     P=0.317N     |
|COCH-ARM / FISHERS |     P=0.544N     P=0.309N     P=0.500      P=0.500N    |P=0.095N     P=0.159      P=0.500N     P=0.309N     |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      62.5 PPB     125 PPB      250 PPB     |CONTROL      62.5 PPB     125 PPB      250 PPB      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|All Organs                                                                                                                       |
|     Histiocytic Sarcoma                                                                                                         |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     3/50 (6%)    1/50 (2%)    0/50 (0%)    0/50 (0%)   |1/50 (2%)    0/50 (0%)    1/50 (2%)    1/50 (2%)    |
|POLY-3 ADJUSTED (b)|     6.9%         2.5%         0.0%         0.0%        |2.2%         0.0%         2.2%         2.3%         |
|TERMINAL (d)       |     1/31 (3%)    0/27 (0%)    0/40 (0%)    0/38 (0%)   |0/34 (0%)    0/37 (0%)    0/35 (0%)    1/32 (3%)    |
|FIRST INCIDENCE    |     573          616          ---          ---         |558          ---          704          735 (T)      |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.037N*    P=0.349N     P=0.102N     P=0.106N    |P=0.525      P=0.504N     P=0.752N     P=0.749      |
|POLY 3             |     P=0.039N*    P=0.332N     P=0.112N     P=0.110N    |P=0.526      P=0.498N     P=0.757N     P=0.753      |
|POLY 1.5           |     P=0.041N*    P=0.321N     P=0.116N     P=0.114N    |P=0.532      P=0.498N     P=0.757N     P=0.756      |
|POLY 6             |     P=0.037N*    P=0.344N     P=0.107N     P=0.107N    |P=0.519      P=0.496N     P=0.756N     P=0.749      |
|LOGISTIC REGRESSION|     P=0.047N*    P=0.285N     P=0.124N     P=0.132N    |P=0.539      P=0.584N     P=0.717      P=0.761      |
|COCH-ARM / FISHERS |     P=0.044N*    P=0.309N     P=0.121N     P=0.121N    |P=0.539      P=0.500N     P=0.753N     P=0.753N     |
|=================================================================================================================================|
       Date:  07/13/98                           EXPERIMENT: 05184 TEST: 06                                            Page 19
                     Statistical Analysis of Primary Tumors in Mice(B6C3F1)       -                   GLUTARALDEHYDE
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      62.5 PPB     125 PPB      250 PPB     |CONTROL      62.5 PPB     125 PPB      250 PPB      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|All Organs                                                                                                                       |
|     Malignant Lymphoma: Histiocytic, Lymphocytic, Mixed,                                                                        |
|     NOS, or Undifferentiated Cell Type                                                                                          |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     4/50 (8%)    5/50 (10%)   1/50 (2%)    5/50 (10%)  |12/50 (24%)  12/50 (24%)  8/50 (16%)   12/50 (24%)  |
|POLY-3 ADJUSTED (b)|     9.3%         12.4%        2.2%         11.0%       |26.7%        26.2%        17.2%        26.5%        |
|TERMINAL (d)       |     3/31 (10%)   2/27 (7%)    1/40 (3%)    5/38 (13%)  |9/34 (27%)   10/37 (27%)  5/35 (14%)   8/32 (25%)   |
|FIRST INCIDENCE    |     670          640          733 (T)      733 (T)     |686          707          672          542          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.475N     P=0.423      P=0.122N     P=0.616     |P=0.511      P=0.493N     P=0.211N     P=0.535      |
|POLY 3             |     P=0.558      P=0.462      P=0.165N     P=0.536     |P=0.495N     P=0.570N     P=0.200N     P=0.586N     |
|POLY 1.5           |     P=0.542      P=0.477      P=0.172N     P=0.521     |P=0.495N     P=0.577N     P=0.208N     P=0.587N     |
|POLY 6             |     P=0.576      P=0.447      P=0.154N     P=0.552     |P=0.493N     P=0.557N     P=0.191N     P=0.581N     |
|LOGISTIC REGRESSION|     P=0.551N     P=0.450      P=0.155N     P=0.571     |P=0.529N     P=0.534N     P=0.199N     P=0.576      |
|COCH-ARM / FISHERS |     P=0.518      P=0.500      P=0.181N     P=0.500     |P=0.500N     P=0.592N     P=0.227N     P=0.592N     |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      62.5 PPB     125 PPB      250 PPB     |CONTROL      62.5 PPB     125 PPB      250 PPB      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|All Organs                                                                                                                       |
|     Benign Tumors                                                                                                               |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     27/50 (54%)  24/50 (48%)  29/50 (58%)  19/50 (38%) |32/50 (64%)  32/50 (64%)  30/50 (60%)  26/50 (52%)  |
|POLY-3 ADJUSTED (b)|     60.3%        56.2%        62.4%        40.8%       |70.5%        67.7%        62.1%        56.7%        |
|TERMINAL (d)       |     21/31 (68%)  17/27 (63%)  25/40 (63%)  15/38 (40%) |27/34 (79%)  28/37 (76%)  23/35 (66%)  20/32 (63%)  |
|FIRST INCIDENCE    |     516          517          492          628         |616          463          502          552          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.006N**   P=0.560      P=0.258N     P=0.017N*   |P=0.222N     P=0.361N     P=0.347N     P=0.248N     |
|POLY 3             |     P=0.033N*    P=0.430N     P=0.504      P=0.045N*   |P=0.079N     P=0.476N     P=0.256N     P=0.116N     |
|POLY 1.5           |     P=0.049N*    P=0.396N     P=0.460      P=0.057N    |P=0.087N     P=0.512N     P=0.311N     P=0.129N     |
|POLY 6             |     P=0.020N*    P=0.463N     P=0.571      P=0.033N*   |P=0.067N     P=0.431N     P=0.200N     P=0.097N     |
|LOGISTIC REGRESSION|     P=0.032N*    P=0.472N     P=0.507      P=0.042N*   |P=0.124N     P=0.523N     P=0.342N     P=0.186N     |
|COCH-ARM / FISHERS |     P=0.086N     P=0.345N     P=0.420      P=0.080N    |P=0.102N     P=0.582N     P=0.418N     P=0.156N     |
|=================================================================================================================================|
       Date:  07/13/98                           EXPERIMENT: 05184 TEST: 06                                            Page 20
                     Statistical Analysis of Primary Tumors in Mice(B6C3F1)       -                   GLUTARALDEHYDE
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      62.5 PPB     125 PPB      250 PPB     |CONTROL      62.5 PPB     125 PPB      250 PPB      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|All Organs                                                                                                                       |
|     Malignant Tumors                                                                                                            |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     33/50 (66%)  28/50 (56%)  23/50 (46%)  22/50 (44%) |24/50 (48%)  27/50 (54%)  24/50 (48%)  25/50 (50%)  |
|POLY-3 ADJUSTED (b)|     67.2%        58.2%        47.5%        46.1%       |51.6%        56.6%        50.3%        53.8%        |
|TERMINAL (d)       |     15/31 (48%)  8/27 (30%)   17/40 (43%)  14/38 (37%) |15/34 (44%)  18/37 (49%)  15/35 (43%)  17/32 (53%)  |
|FIRST INCIDENCE    |     454          364          470          558         |558          492          570          401          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.006N**   P=0.457N     P=0.016N*    P=0.016N*   |P=0.409      P=0.507      P=0.510N     P=0.420      |
|POLY 3             |     P=0.018N*    P=0.240N     P=0.037N*    P=0.027N*   |P=0.526      P=0.391      P=0.531N     P=0.498      |
|POLY 1.5           |     P=0.017N*    P=0.226N     P=0.035N*    P=0.024N*   |P=0.538N     P=0.378      P=0.543N     P=0.508      |
|POLY 6             |     P=0.021N*    P=0.256N     P=0.040N*    P=0.032N*   |P=0.501      P=0.408      P=0.524N     P=0.479      |
|LOGISTIC REGRESSION|     P=0.030N*    P=0.130N     P=0.044N*    P=0.030N*   |P=0.521      P=0.367      P=0.544N     P=0.486      |
|COCH-ARM / FISHERS |     P=0.016N*    P=0.206N     P=0.035N*    P=0.022N*   |P=0.538      P=0.345      P=0.579N     P=0.500      |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      62.5 PPB     125 PPB      250 PPB     |CONTROL      62.5 PPB     125 PPB      250 PPB      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|All Organs                                                                                                                       |
|     Malignant and Benign Tumors                                                                                                 |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     44/50 (88%)  42/50 (84%)  39/50 (78%)  33/50 (66%) |41/50 (82%)  45/50 (90%)  41/50 (82%)  40/50 (80%)  |
|POLY-3 ADJUSTED (b)|     89.6%        86.9%        80.4%        68.6%       |87.4%        91.6%        82.6%        82.8%        |
|TERMINAL (d)       |     26/31 (84%)  21/27 (78%)  32/40 (80%)  24/38 (63%) |31/34 (91%)  34/37 (92%)  27/35 (77%)  27/32 (84%)  |
|FIRST INCIDENCE    |     454          364          470          558         |558          463          502          401          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P<0.001N**   P=0.388      P=0.019N*    P=0.005N**  |P=0.489      P=0.536      P=0.472N     P=0.496      |
|POLY 3             |     P=0.002N**   P=0.459N     P=0.159N     P=0.009N**  |P=0.185N     P=0.356      P=0.348N     P=0.362N     |
|POLY 1.5           |     P=0.002N**   P=0.431N     P=0.151N     P=0.008N**  |P=0.215N     P=0.296      P=0.435N     P=0.405N     |
|POLY 6             |     P=0.003N**   P=0.480N     P=0.175N     P=0.011N*   |P=0.156N     P=0.424      P=0.264N     P=0.318N     |
|LOGISTIC REGRESSION|     P=0.002N**   P=0.412N     P=0.133N     P=0.007N**  |P=0.316N     P=0.219      P=0.516N     P=0.544N     |
|COCH-ARM / FISHERS |     P=0.003N**   P=0.387N     P=0.143N     P=0.008N**  |P=0.292N     P=0.194      P=0.602N     P=0.500N     |
|=================================================================================================================================|

(a)  Number of tumor-bearing animals /  number of animals examined at site.
(b)  Poly-3 adjusted lifetime tumor incidence.
(d)  Observed incidence at terminal kill.
(f)  Beneath the control incidence are the P-values associated with the trend 
test.  Beneath the dosed group incidence are the P-values corresponding to 
pairwise comparisons between the controls and that dosed group.  The life
table analysis regards tumors in animals dying prior to  terminal kill as
 being (directly or indirectly) the cause of death.
Logistic regression is an alternative
 method for analyzing the incidence of non-fatal tumors. The Cochran-Armitage
and Fishers exact tests compare directly the overall incidence rates
For all tests a negative trend is indicated by N
(e)  Value of Statistic cannot be computed.
(I)  Interim sacrifice
(T)  Terminal sacrifice
#   Tumor rates based on number of animals necropsied.
*   To the right of any statistical result, indicates significance at (P<=0.05).
**  To the right of any statistical result, indicates significance at (P<=0.01).