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TDMS Study 05184-06 Pathology Tables

NTP                                    STATISTICAL ANALYSIS OF NON-NEOPLASTIC LESIONS                          REPORT: PEIRPT10     
LAB: Battelle Northwest                                      GLUTARALDEHYDE                                    DATE: 07/13/98       
EXPERIMENT: 05184 TEST: 06                                                                                     TIME: 08:41:09       
TEST TYPE:  CHRONIC                             CAGES FROM 0000 TO LAST CAGE                                   PAGE:       1        
CONT: NO1-ES-25335                              ROUTE: RESPIRATORY EXPOSURE WHOLE BODY                         NTP C#: 55425C       
PATHOLOGIST: GRUMBEIN, S.                                                                                      CAS: 111-30-8        
------------------------------------------------------------------------------------------------------------------------------------
                                                                                                                                    
                                                             CORE STUDY                                                             
                                                                                                                                    

               REASONS FOR REMOVAL:    ALL                                                                                          
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
               REMOVAL DATE RANGE:     ALL                                                                                          
                                                                                                                                    
               TREATMENT GROUPS:       INCLUDE ALL                                                                                  
NTP                                    STATISTICAL ANALYSIS OF NON-NEOPLASTIC LESIONS                          REPORT: PEIRPT10   
LAB: Battelle Northwest                                      GLUTARALDEHYDE                                    DATE: 07/13/98     
EXPERIMENT: 05184 TEST: 06                                                                                     TIME: 08:41:09     
TEST TYPE:  CHRONIC                             CAGES FROM 0000 TO LAST CAGE                                                      
CONT: NO1-ES-25335                              ROUTE: RESPIRATORY EXPOSURE WHOLE BODY                         NTP C#: 55425C     
PATHOLOGIST: GRUMBEIN, S.                                                                                      CAS: 111-30-8      



SUMMARY OF STATISTICALLY SIGNIFICANT (P<=.05) RESULTS
IN THE ANALYSIS OF                  GLUTARALDEHYDE
===============================================================

Male Mice
------------
Organ                                 Morphology
-----                                 ----------
Kidney                                 Cyst
Kidney: Papilla                        Inflammation
Liver                                  Eosinophilic Focus
                                       Fatty Change
Nose: Respiratory Epithelium           Degeneration Hyaline
                                       Metaplasia
===============================================================
Female Mice
------------
Organ                                  Morphology
-----                                  ----------
Liver                                  Eosinophilic Focus
Lung: Alveolar Epithelium              Hyperplasia
Lymph Node, Mesenteric                 Hyperplasia Lymphoid
Nose                                   Inflammation
Nose: Respiratory Epithelium           Degeneration Hyaline
                                       Metaplasia
Pituitary Gland: Pars Distalis         Hyperplasia
Spleen                                 Hyperplasia Lymphoid
Thyroid Gland: Follicular Cell         Hyperplasia
===============================================================
       Date:  07/13/98                           EXPERIMENT: 05184 TEST: 06                                            Page 1
                     Statistical Analysis of Non-neoplastic Lesions in        Mice(B6C3F1)  -                   GLUTARALDEHYDE
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      62.5 PPB     125 PPB      250 PPB     |CONTROL      62.5 PPB     125 PPB      250 PPB      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Adrenal Cortex                                                                                                                   |
|     Hyperplasia                                                                                                                 |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     10/47 (21%)  9/49 (18%)   18/50 (36%)  12/49 (24%) |2/50 (4%)    2/49 (4%)    7/49 (14%)   1/50 (2%)    |
|POLY-3 ADJUSTED (b)|     23.7%        22.5%        40.0%        26.0%       |4.4%         4.4%         15.3%        2.3%         |
|TERMINAL (d)       |     8/31 (26%)   7/27 (26%)   17/40 (43%)  8/38 (21%)  |1/34 (3%)    1/37 (3%)    6/35 (17%)   0/32 (0%)    |
|FIRST INCIDENCE    |     359          588          715          558         |616          706          502          723          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.525      P=0.585      P=0.198      P=0.575     |P=0.535N     P=0.663N     P=0.091      P=0.512N     |
|POLY 3             |     P=0.382      P=0.553N     P=0.079      P=0.501     |P=0.529N     P=0.692N     P=0.083      P=0.511N     |
|POLY 1.5           |     P=0.333      P=0.518N     P=0.077      P=0.476     |P=0.515N     P=0.692      P=0.081      P=0.505N     |
|POLY 6             |     P=0.450      P=0.588N     P=0.089      P=0.538     |P=0.546N     P=0.687N     P=0.084      P=0.516N     |
|LOGISTIC REGRESSION|     P=0.353      P=0.509N     P=0.097      P=0.436     |P=0.497N     P=0.684      P=0.069      P=0.499N     |
|COCH-ARM / FISHERS |     P=0.276      P=0.459N     P=0.084      P=0.448     |P=0.498N     P=0.684      P=0.075      P=0.500N     |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      62.5 PPB     125 PPB      250 PPB     |CONTROL      62.5 PPB     125 PPB      250 PPB      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Adrenal Cortex                                                                                                                   |
|     Hypertrophy                                                                                                                 |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     32/47 (68%)  26/49 (53%)  31/50 (62%)  34/49 (69%) |2/50 (4%)    2/49 (4%)    1/49 (2%)    2/50 (4%)    |
|POLY-3 ADJUSTED (b)|     76.6%        62.6%        66.6%        75.0%       |4.5%         4.4%         2.2%         4.6%         |
|TERMINAL (d)       |     27/31 (87%)  20/27 (74%)  27/40 (68%)  31/38 (82%) |1/34 (3%)    2/37 (5%)    1/35 (3%)    1/32 (3%)    |
|FIRST INCIDENCE    |     602          402          470          641         |708          735 (T)      735 (T)      723          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.201N     P=0.388N     P=0.055N     P=0.205N    |P=0.602      P=0.659N     P=0.487N     P=0.681      |
|POLY 3             |     P=0.446      P=0.107N     P=0.204N     P=0.532N    |P=0.582N     P=0.691N     P=0.497N     P=0.686      |
|POLY 1.5           |     P=0.374      P=0.099N     P=0.263N     P=0.580N    |P=0.578N     P=0.693      P=0.499N     P=0.690      |
|POLY 6             |     P=0.535      P=0.132N     P=0.140N     P=0.479N    |P=0.586N     P=0.685N     P=0.494N     P=0.682      |
|LOGISTIC REGRESSION|     P=0.515N     P=0.217N     P=0.237N     P=0.368N    |P=0.599N     P=0.681N     P=0.492N     P=0.684      |
|COCH-ARM / FISHERS |     P=0.294      P=0.097N     P=0.340N     P=0.533     |P=0.575N     P=0.684      P=0.508N     P=0.691N     |
|=================================================================================================================================|
       Date:  07/13/98                           EXPERIMENT: 05184 TEST: 06                                            Page 2
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                   GLUTARALDEHYDE
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      62.5 PPB     125 PPB      250 PPB     |CONTROL      62.5 PPB     125 PPB      250 PPB      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Adrenal Medulla                                                                                                                  |
|     Hyperplasia                                                                                                                 |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     2/47 (4%)    2/49 (4%)    2/50 (4%)    2/49 (4%)   |3/50 (6%)    1/49 (2%)    5/48 (10%)   1/49 (2%)    |
|POLY-3 ADJUSTED (b)|     4.9%         5.1%         4.4%         4.5%        |6.7%         2.2%         11.1%        2.3%         |
|TERMINAL (d)       |     2/31 (7%)    0/27 (0%)    2/40 (5%)    2/38 (5%)   |3/34 (9%)    0/37 (0%)    4/35 (11%)   0/31 (0%)    |
|FIRST INCIDENCE    |     733 (T)      707          733 (T)      733 (T)     |735 (T)      706          502          660          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.482N     P=0.644      P=0.600N     P=0.620N    |P=0.411N     P=0.269N     P=0.372      P=0.334N     |
|POLY 3             |     P=0.550N     P=0.682      P=0.659N     P=0.660N    |P=0.399N     P=0.300N     P=0.360      P=0.319N     |
|POLY 1.5           |     P=0.563N     P=0.692      P=0.666N     P=0.668N    |P=0.390N     P=0.305N     P=0.352      P=0.316N     |
|POLY 6             |     P=0.535N     P=0.670      P=0.647N     P=0.650N    |P=0.408N     P=0.293N     P=0.368      P=0.321N     |
|LOGISTIC REGRESSION|     P=0.513N     P=0.662      P=0.600N     P=0.620N    |P=0.379N     P=0.290N     P=0.334      P=0.321N     |
|COCH-ARM / FISHERS |     P=0.582N     P=0.676N     P=0.668N     P=0.676N    |P=0.380N     P=0.316N     P=0.335      P=0.316N     |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      62.5 PPB     125 PPB      250 PPB     |CONTROL      62.5 PPB     125 PPB      250 PPB      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Epididymis                                                                                                                       |
|     Granuloma Sperm                                                                                                             |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     2/48 (4%)    0/50 (0%)    0/50 (0%)    1/49 (2%)   |                                                    |
|POLY-3 ADJUSTED (b)|     4.7%         0.0%         0.0%         2.2%        |                                                    |
|TERMINAL (d)       |     1/31 (3%)    0/27 (0%)    0/40 (0%)    0/38 (0%)   |                                                    |
|FIRST INCIDENCE    |     573          ---          ---          672         |                                                    |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.418N     P=0.263N     P=0.212N     P=0.460N    |                                                    |
|POLY 3             |     P=0.440N     P=0.249N     P=0.223N     P=0.477N    |                                                    |
|POLY 1.5           |     P=0.447N     P=0.241N     P=0.226N     P=0.483N    |                                                    |
|POLY 6             |     P=0.431N     P=0.260N     P=0.217N     P=0.468N    |                                                    |
|LOGISTIC REGRESSION|     P=0.477N     P=0.212N     P=0.229N     P=0.518N    |                                                    |
|COCH-ARM / FISHERS |     P=0.458N     P=0.237N     P=0.237N     P=0.492N    |                                                    |
|=================================================================================================================================|
       Date:  07/13/98                           EXPERIMENT: 05184 TEST: 06                                            Page 3
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                   GLUTARALDEHYDE
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      62.5 PPB     125 PPB      250 PPB     |CONTROL      62.5 PPB     125 PPB      250 PPB      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Heart: Atrium                                                                                                                    |
|     Thrombosis                                                                                                                  |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     0/49 (0%)    0/50 (0%)    0/50 (0%)    0/49 (0%)   |2/50 (4%)    0/49 (0%)    0/50 (0%)    0/50 (0%)    |
|POLY-3 ADJUSTED (b)|     0.0%         0.0%         0.0%         0.0%        |4.5%         0.0%         0.0%         0.0%         |
|TERMINAL (d)       |     0/31 (0%)    0/27 (0%)    0/40 (0%)    0/38 (0%)   |1/34 (3%)    0/37 (0%)    0/35 (0%)    0/32 (0%)    |
|FIRST INCIDENCE    |     ---          ---          ---          ---         |704          ---          ---          ---          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     (e)          (e)          (e)          (e)         |P=0.118N     P=0.214N     P=0.231N     P=0.246N     |
|POLY 3             |     (e)          (e)          (e)          (e)         |P=0.114N     P=0.235N     P=0.231N     P=0.243N     |
|POLY 1.5           |     (e)          (e)          (e)          (e)         |P=0.114N     P=0.238N     P=0.233N     P=0.240N     |
|POLY 6             |     (e)          (e)          (e)          (e)         |P=0.114N     P=0.232N     P=0.231N     P=0.246N     |
|LOGISTIC REGRESSION|     (e)          (e)          (e)          (e)         |P=0.115N     P=0.235N     P=0.231N     P=0.243N     |
|COCH-ARM / FISHERS |     (e)          (e)          (e)          (e)         |P=0.115N     P=0.253N     P=0.247N     P=0.247N     |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      62.5 PPB     125 PPB      250 PPB     |CONTROL      62.5 PPB     125 PPB      250 PPB      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Islets, Pancreatic                                                                                                               |
|     Hyperplasia                                                                                                                 |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     3/47 (6%)    2/48 (4%)    1/50 (2%)    6/48 (13%)  |1/50 (2%)    0/48 (0%)    2/49 (4%)    1/49 (2%)    |
|POLY-3 ADJUSTED (b)|     7.3%         5.2%         2.2%         13.2%       |2.2%         0.0%         4.4%         2.3%         |
|TERMINAL (d)       |     2/31 (7%)    1/27 (4%)    0/40 (0%)    5/38 (13%)  |1/34 (3%)    0/37 (0%)    1/35 (3%)    1/32 (3%)    |
|FIRST INCIDENCE    |     688          706          470          558         |735 (T)      ---          524          735 (T)      |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.188      P=0.556N     P=0.248N     P=0.339     |P=0.479      P=0.483N     P=0.509      P=0.748      |
|POLY 3             |     P=0.143      P=0.530N     P=0.267N     P=0.294     |P=0.480      P=0.499N     P=0.509      P=0.753      |
|POLY 1.5           |     P=0.132      P=0.514N     P=0.275N     P=0.278     |P=0.487      P=0.502N     P=0.504      P=0.754      |
|POLY 6             |     P=0.154      P=0.547N     P=0.256N     P=0.309     |P=0.472      P=0.494N     P=0.514      P=0.751      |
|LOGISTIC REGRESSION|     P=0.114      P=0.546N     P=0.285N     P=0.266     |P=0.502      (e)          P=0.448      P=0.748      |
|COCH-ARM / FISHERS |     P=0.117      P=0.490N     P=0.285N     P=0.254     |P=0.497      P=0.510N     P=0.492      P=0.747      |
|=================================================================================================================================|
       Date:  07/13/98                           EXPERIMENT: 05184 TEST: 06                                            Page 4
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                   GLUTARALDEHYDE
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      62.5 PPB     125 PPB      250 PPB     |CONTROL      62.5 PPB     125 PPB      250 PPB      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Kidney                                                                                                                           |
|     Cyst                                                                                                                        |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     0/48 (0%)    4/49 (8%)    2/50 (4%)    0/49 (0%)   |0/50 (0%)    0/49 (0%)    0/49 (0%)    0/49 (0%)    |
|POLY-3 ADJUSTED (b)|     0.0%         10.2%        4.4%         0.0%        |0.0%         0.0%         0.0%         0.0%         |
|TERMINAL (d)       |     0/31 (0%)    3/27 (11%)   2/40 (5%)    0/38 (0%)   |0/34 (0%)    0/37 (0%)    0/35 (0%)    0/32 (0%)    |
|FIRST INCIDENCE    |     ---          707          733 (T)      ---         |---          ---          ---          ---          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.254N     P=0.048 *    P=0.296      (e)         |(e)          (e)          (e)          (e)          |
|POLY 3             |     P=0.308N     P=0.053      P=0.254      (e)         |(e)          (e)          (e)          (e)          |
|POLY 1.5           |     P=0.316N     P=0.057      P=0.250      (e)         |(e)          (e)          (e)          (e)          |
|POLY 6             |     P=0.297N     P=0.049 *    P=0.263      (e)         |(e)          (e)          (e)          (e)          |
|LOGISTIC REGRESSION|     P=0.277N     P=0.048 *    P=0.296      (e)         |(e)          (e)          (e)          (e)          |
|COCH-ARM / FISHERS |     P=0.330N     P=0.061      P=0.258      (e)         |(e)          (e)          (e)          (e)          |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      62.5 PPB     125 PPB      250 PPB     |CONTROL      62.5 PPB     125 PPB      250 PPB      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Kidney                                                                                                                           |
|     Hydronephrosis                                                                                                              |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     2/48 (4%)    3/49 (6%)    2/50 (4%)    1/49 (2%)   |0/50 (0%)    0/49 (0%)    1/49 (2%)    0/49 (0%)    |
|POLY-3 ADJUSTED (b)|     4.7%         7.3%         4.4%         2.2%        |0.0%         0.0%         2.2%         0.0%         |
|TERMINAL (d)       |     0/31 (0%)    0/27 (0%)    1/40 (3%)    0/38 (0%)   |0/34 (0%)    0/37 (0%)    1/35 (3%)    0/32 (0%)    |
|FIRST INCIDENCE    |     616          402          702          327         |---          ---          735 (T)      ---          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.275N     P=0.474      P=0.630N     P=0.474N    |P=0.686      (e)          P=0.506      (e)          |
|POLY 3             |     P=0.279N     P=0.490      P=0.670N     P=0.471N    |P=0.679      (e)          P=0.502      (e)          |
|POLY 1.5           |     P=0.289N     P=0.498      P=0.675N     P=0.479N    |P=0.685      (e)          P=0.501      (e)          |
|POLY 6             |     P=0.269N     P=0.480      P=0.660N     P=0.464N    |P=0.674      (e)          P=0.504      (e)          |
|LOGISTIC REGRESSION|     P=0.384N     P=0.642      P=0.682N     P=0.562N    |(e)          (e)          P=0.506      (e)          |
|COCH-ARM / FISHERS |     P=0.305N     P=0.510      P=0.676N     P=0.492N    |P=0.692      (e)          P=0.495      (e)          |
|=================================================================================================================================|
       Date:  07/13/98                           EXPERIMENT: 05184 TEST: 06                                            Page 5
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                   GLUTARALDEHYDE
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      62.5 PPB     125 PPB      250 PPB     |CONTROL      62.5 PPB     125 PPB      250 PPB      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Kidney                                                                                                                           |
|     Infarct                                                                                                                     |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     0/48 (0%)    0/49 (0%)    0/50 (0%)    0/49 (0%)   |1/50 (2%)    2/49 (4%)    3/49 (6%)    2/49 (4%)    |
|POLY-3 ADJUSTED (b)|     0.0%         0.0%         0.0%         0.0%        |2.2%         4.4%         6.6%         4.6%         |
|TERMINAL (d)       |     0/31 (0%)    0/27 (0%)    0/40 (0%)    0/38 (0%)   |0/34 (0%)    2/37 (5%)    2/35 (6%)    2/32 (6%)    |
|FIRST INCIDENCE    |     ---          ---          ---          ---         |664          735 (T)      570          735 (T)      |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     (e)          (e)          (e)          (e)         |P=0.370      P=0.525      P=0.321      P=0.480      |
|POLY 3             |     (e)          (e)          (e)          (e)         |P=0.382      P=0.502      P=0.312      P=0.485      |
|POLY 1.5           |     (e)          (e)          (e)          (e)         |P=0.389      P=0.499      P=0.308      P=0.489      |
|POLY 6             |     (e)          (e)          (e)          (e)         |P=0.374      P=0.507      P=0.315      P=0.481      |
|LOGISTIC REGRESSION|     (e)          (e)          (e)          (e)         |P=0.396      P=0.498      P=0.264      P=0.489      |
|COCH-ARM / FISHERS |     (e)          (e)          (e)          (e)         |P=0.397      P=0.492      P=0.301      P=0.492      |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      62.5 PPB     125 PPB      250 PPB     |CONTROL      62.5 PPB     125 PPB      250 PPB      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Kidney                                                                                                                           |
|     Metaplasia Osseous                                                                                                          |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     0/48 (0%)    1/49 (2%)    2/50 (4%)    0/49 (0%)   |1/50 (2%)    0/49 (0%)    0/49 (0%)    2/49 (4%)    |
|POLY-3 ADJUSTED (b)|     0.0%         2.5%         4.4%         0.0%        |2.2%         0.0%         0.0%         4.6%         |
|TERMINAL (d)       |     0/31 (0%)    1/27 (4%)    2/40 (5%)    0/38 (0%)   |0/34 (0%)    0/37 (0%)    0/35 (0%)    2/32 (6%)    |
|FIRST INCIDENCE    |     ---          733 (T)      733 (T)      ---         |704          ---          ---          735 (T)      |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.545N     P=0.472      P=0.296      (e)         |P=0.227      P=0.470N     P=0.489N     P=0.486      |
|POLY 3             |     P=0.586N     P=0.488      P=0.254      (e)         |P=0.238      P=0.498N     P=0.498N     P=0.486      |
|POLY 1.5           |     P=0.597N     P=0.495      P=0.250      (e)         |P=0.240      P=0.500N     P=0.500N     P=0.490      |
|POLY 6             |     P=0.574N     P=0.481      P=0.263      (e)         |P=0.235      P=0.495N     P=0.497N     P=0.483      |
|LOGISTIC REGRESSION|     (e)          P=0.472      P=0.296      (e)         |P=0.233      P=0.504N     P=0.505N     P=0.485      |
|COCH-ARM / FISHERS |     P=0.612N     P=0.505      P=0.258      (e)         |P=0.243      P=0.505N     P=0.505N     P=0.492      |
|=================================================================================================================================|
       Date:  07/13/98                           EXPERIMENT: 05184 TEST: 06                                            Page 6
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                   GLUTARALDEHYDE
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      62.5 PPB     125 PPB      250 PPB     |CONTROL      62.5 PPB     125 PPB      250 PPB      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Kidney                                                                                                                           |
|     Nephropathy                                                                                                                 |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     44/48 (92%)  43/49 (88%)  46/50 (92%)  47/49 (96%) |20/50 (40%)  14/49 (29%)  19/49 (39%)  16/49 (33%)  |
|POLY-3 ADJUSTED (b)|     96.5%        91.8%        96.6%        98.0%       |43.7%        30.4%        39.6%        35.9%        |
|TERMINAL (d)       |     31/31 (100%) 27/27 (100%) 40/40 (100%) 38/38 (100%)|16/34 (47%)  10/37 (27%)  12/35 (34%)  10/32 (31%)  |
|FIRST INCIDENCE    |     516          364          470          504         |558          551          502          542          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.064N     P=0.276      P=0.056N     P=0.195N    |P=0.460N     P=0.099N     P=0.453N     P=0.339N     |
|POLY 3             |     P=0.251      P=0.275N     P=0.745      P=0.590     |P=0.388N     P=0.134N     P=0.423N     P=0.295N     |
|POLY 1.5           |     P=0.194      P=0.307N     P=0.676      P=0.441     |P=0.381N     P=0.143N     P=0.461N     P=0.291N     |
|POLY 6             |     P=0.378      P=0.272N     P=0.792N     P=0.791     |P=0.394N     P=0.121N     P=0.383N     P=0.296N     |
|LOGISTIC REGRESSION|     P=0.313      P=0.557N     P=0.644      P=0.508     |P=0.380N     P=0.139N     P=0.540N     P=0.305N     |
|COCH-ARM / FISHERS |     P=0.180      P=0.383N     P=0.619      P=0.329     |P=0.376N     P=0.162N     P=0.532N     P=0.291N     |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      62.5 PPB     125 PPB      250 PPB     |CONTROL      62.5 PPB     125 PPB      250 PPB      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Kidney: Papilla                                                                                                                  |
|     Inflammation                                                                                                                |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     0/48 (0%)    0/49 (0%)    0/50 (0%)    2/49 (4%)   |0/50 (0%)    0/49 (0%)    0/49 (0%)    0/49 (0%)    |
|POLY-3 ADJUSTED (b)|     0.0%         0.0%         0.0%         4.3%        |0.0%         0.0%         0.0%         0.0%         |
|TERMINAL (d)       |     0/31 (0%)    0/27 (0%)    0/40 (0%)    0/38 (0%)   |0/34 (0%)    0/37 (0%)    0/35 (0%)    0/32 (0%)    |
|FIRST INCIDENCE    |     ---          ---          ---          327         |---          ---          ---          ---          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.054      (e)          (e)          P=0.253     |(e)          (e)          (e)          (e)          |
|POLY 3             |     P=0.052      (e)          (e)          P=0.261     |(e)          (e)          (e)          (e)          |
|POLY 1.5           |     P=0.049 *    (e)          (e)          P=0.253     |(e)          (e)          (e)          (e)          |
|POLY 6             |     P=0.055      (e)          (e)          P=0.269     |(e)          (e)          (e)          (e)          |
|LOGISTIC REGRESSION|     P=0.021 *    (e)          (e)          P=0.173     |(e)          (e)          (e)          (e)          |
|COCH-ARM / FISHERS |     P=0.047 *    (e)          (e)          P=0.253     |(e)          (e)          (e)          (e)          |
|=================================================================================================================================|
       Date:  07/13/98                           EXPERIMENT: 05184 TEST: 06                                            Page 7
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                   GLUTARALDEHYDE
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      62.5 PPB     125 PPB      250 PPB     |CONTROL      62.5 PPB     125 PPB      250 PPB      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Larynx: Glands                                                                                                                   |
|     Inflammation                                                                                                                |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     5/47 (11%)   3/49 (6%)    3/50 (6%)    3/50 (6%)   |0/50 (0%)    0/49 (0%)    0/50 (0%)    0/48 (0%)    |
|POLY-3 ADJUSTED (b)|     11.9%        7.6%         6.7%         6.5%        |0.0%         0.0%         0.0%         0.0%         |
|TERMINAL (d)       |     2/31 (7%)    3/27 (11%)   3/40 (8%)    2/38 (5%)   |0/34 (0%)    0/37 (0%)    0/35 (0%)    0/31 (0%)    |
|FIRST INCIDENCE    |     602          733 (T)      733 (T)      558         |---          ---          ---          ---          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.214N     P=0.429N     P=0.272N     P=0.285N    |(e)          (e)          (e)          (e)          |
|POLY 3             |     P=0.258N     P=0.394N     P=0.320N     P=0.307N    |(e)          (e)          (e)          (e)          |
|POLY 1.5           |     P=0.271N     P=0.369N     P=0.323N     P=0.313N    |(e)          (e)          (e)          (e)          |
|POLY 6             |     P=0.245N     P=0.427N     P=0.313N     P=0.304N    |(e)          (e)          (e)          (e)          |
|LOGISTIC REGRESSION|     P=0.282N     P=0.347N     P=0.324N     P=0.352N    |(e)          (e)          (e)          (e)          |
|COCH-ARM / FISHERS |     P=0.291N     P=0.334N     P=0.323N     P=0.323N    |(e)          (e)          (e)          (e)          |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      62.5 PPB     125 PPB      250 PPB     |CONTROL      62.5 PPB     125 PPB      250 PPB      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Liver                                                                                                                            |
|     Basophilic Focus                                                                                                            |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     5/49 (10%)   8/50 (16%)   4/50 (8%)    6/49 (12%)  |2/50 (4%)    4/48 (8%)    5/50 (10%)   2/50 (4%)    |
|POLY-3 ADJUSTED (b)|     11.8%        19.3%        8.9%         13.4%       |4.5%         8.9%         10.9%        4.6%         |
|TERMINAL (d)       |     4/31 (13%)   5/27 (19%)   4/40 (10%)   6/38 (16%)  |1/34 (3%)    3/37 (8%)    4/35 (11%)   1/32 (3%)    |
|FIRST INCIDENCE    |     626          402          733 (T)      733 (T)     |701          714          719          707          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.361N     P=0.212      P=0.358N     P=0.619N    |P=0.558N     P=0.381      P=0.233      P=0.682      |
|POLY 3             |     P=0.498N     P=0.260      P=0.462N     P=0.541     |P=0.533N     P=0.339      P=0.227      P=0.686      |
|POLY 1.5           |     P=0.519N     P=0.273      P=0.475N     P=0.524     |P=0.523N     P=0.332      P=0.225      P=0.690      |
|POLY 6             |     P=0.474N     P=0.245      P=0.441N     P=0.559     |P=0.543N     P=0.349      P=0.228      P=0.682      |
|LOGISTIC REGRESSION|     P=0.505N     P=0.280      P=0.440N     P=0.572     |P=0.544N     P=0.348      P=0.230      P=0.686      |
|COCH-ARM / FISHERS |     P=0.548N     P=0.290      P=0.487N     P=0.500     |P=0.512N     P=0.319      P=0.218      P=0.691N     |
|=================================================================================================================================|
       Date:  07/13/98                           EXPERIMENT: 05184 TEST: 06                                            Page 8
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                   GLUTARALDEHYDE
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      62.5 PPB     125 PPB      250 PPB     |CONTROL      62.5 PPB     125 PPB      250 PPB      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Liver                                                                                                                            |
|     Clear Cell Focus                                                                                                            |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     9/49 (18%)   6/50 (12%)   9/50 (18%)   7/49 (14%)  |2/50 (4%)    1/48 (2%)    0/50 (0%)    0/50 (0%)    |
|POLY-3 ADJUSTED (b)|     21.4%        14.9%        20.0%        15.5%       |4.4%         2.2%         0.0%         0.0%         |
|TERMINAL (d)       |     8/31 (26%)   5/27 (19%)   9/40 (23%)   6/38 (16%)  |1/34 (3%)    1/37 (3%)    0/35 (0%)    0/32 (0%)    |
|FIRST INCIDENCE    |     723          598          733 (T)      673         |614          735 (T)      ---          ---          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.218N     P=0.389N     P=0.367N     P=0.242N    |P=0.106N     P=0.486N     P=0.234N     P=0.254N     |
|POLY 3             |     P=0.348N     P=0.313N     P=0.541N     P=0.332N    |P=0.101N     P=0.501N     P=0.233N     P=0.244N     |
|POLY 1.5           |     P=0.385N     P=0.297N     P=0.563N     P=0.357N    |P=0.101N     P=0.506N     P=0.234N     P=0.241N     |
|POLY 6             |     P=0.305N     P=0.332N     P=0.504N     P=0.303N    |P=0.102N     P=0.495N     P=0.233N     P=0.248N     |
|LOGISTIC REGRESSION|     P=0.291N     P=0.360N     P=0.383N     P=0.285N    |P=0.100N     P=0.528N     P=0.253N     P=0.236N     |
|COCH-ARM / FISHERS |     P=0.438N     P=0.274N     P=0.584N     P=0.393N    |P=0.100N     P=0.515N     P=0.247N     P=0.247N     |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      62.5 PPB     125 PPB      250 PPB     |CONTROL      62.5 PPB     125 PPB      250 PPB      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Liver                                                                                                                            |
|     Eosinophilic Focus                                                                                                          |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     7/49 (14%)   6/50 (12%)   5/50 (10%)   3/49 (6%)   |6/50 (12%)   6/48 (13%)   4/50 (8%)    0/50 (0%)    |
|POLY-3 ADJUSTED (b)|     16.7%        15.0%        11.1%        6.7%        |13.4%        13.3%        8.7%         0.0%         |
|TERMINAL (d)       |     7/31 (23%)   5/27 (19%)   5/40 (13%)   3/38 (8%)   |5/34 (15%)   5/37 (14%)   4/35 (11%)   0/32 (0%)    |
|FIRST INCIDENCE    |     733 (T)      685          733 (T)      733 (T)     |704          672          735 (T)      ---          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.043N*    P=0.605N     P=0.212N     P=0.085N    |P=0.013N*    P=0.557N     P=0.349N     P=0.021N*    |
|POLY 3             |     P=0.083N     P=0.535N     P=0.330N     P=0.130N    |P=0.011N*    P=0.615N     P=0.353N     P=0.016N*    |
|POLY 1.5           |     P=0.095N     P=0.515N     P=0.348N     P=0.141N    |P=0.011N*    P=0.614      P=0.357N     P=0.016N*    |
|POLY 6             |     P=0.071N     P=0.558N     P=0.303N     P=0.118N    |P=0.012N*    P=0.598N     P=0.351N     P=0.017N*    |
|LOGISTIC REGRESSION|     P=0.054N     P=0.596N     P=0.212N     P=0.085N    |P=0.012N*    P=0.598N     P=0.345N     P=0.019N*    |
|COCH-ARM / FISHERS |     P=0.114N     P=0.484N     P=0.365N     P=0.159N    |P=0.011N*    P=0.591      P=0.370N     P=0.013N*    |
|=================================================================================================================================|
       Date:  07/13/98                           EXPERIMENT: 05184 TEST: 06                                            Page 9
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                   GLUTARALDEHYDE
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      62.5 PPB     125 PPB      250 PPB     |CONTROL      62.5 PPB     125 PPB      250 PPB      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Liver                                                                                                                            |
|     Fatty Change                                                                                                                |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     0/49 (0%)    0/50 (0%)    0/50 (0%)    2/49 (4%)   |0/50 (0%)    0/48 (0%)    3/50 (6%)    0/50 (0%)    |
|POLY-3 ADJUSTED (b)|     0.0%         0.0%         0.0%         4.5%        |0.0%         0.0%         6.4%         0.0%         |
|TERMINAL (d)       |     0/31 (0%)    0/27 (0%)    0/40 (0%)    2/38 (5%)   |0/34 (0%)    0/37 (0%)    0/35 (0%)    0/32 (0%)    |
|FIRST INCIDENCE    |     ---          ---          ---          733 (T)     |---          ---          640          ---          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.064      (e)          (e)          P=0.284     |P=0.527      (e)          P=0.137      (e)          |
|POLY 3             |     P=0.049 *    (e)          (e)          P=0.252     |P=0.515      (e)          P=0.127      (e)          |
|POLY 1.5           |     P=0.047 *    (e)          (e)          P=0.246     |P=0.528      (e)          P=0.124      (e)          |
|POLY 6             |     P=0.052      (e)          (e)          P=0.260     |P=0.502      (e)          P=0.131      (e)          |
|LOGISTIC REGRESSION|     (e)          (e)          (e)          P=0.284     |P=0.545      (e)          P=0.091      (e)          |
|COCH-ARM / FISHERS |     P=0.045 *    (e)          (e)          P=0.247     |P=0.543      (e)          P=0.121      (e)          |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      62.5 PPB     125 PPB      250 PPB     |CONTROL      62.5 PPB     125 PPB      250 PPB      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Liver                                                                                                                            |
|     Mixed Cell Focus                                                                                                            |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     2/49 (4%)    2/50 (4%)    0/50 (0%)    0/49 (0%)   |0/50 (0%)    0/48 (0%)    0/50 (0%)    0/50 (0%)    |
|POLY-3 ADJUSTED (b)|     4.8%         5.0%         0.0%         0.0%        |0.0%         0.0%         0.0%         0.0%         |
|TERMINAL (d)       |     2/31 (7%)    2/27 (7%)    0/40 (0%)    0/38 (0%)   |0/34 (0%)    0/37 (0%)    0/35 (0%)    0/32 (0%)    |
|FIRST INCIDENCE    |     733 (T)      733 (T)      ---          ---         |---          ---          ---          ---          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.058N     P=0.645      P=0.184N     P=0.195N    |(e)          (e)          (e)          (e)          |
|POLY 3             |     P=0.079N     P=0.676      P=0.222N     P=0.222N    |(e)          (e)          (e)          (e)          |
|POLY 1.5           |     P=0.082N     P=0.686      P=0.227N     P=0.228N    |(e)          (e)          (e)          (e)          |
|POLY 6             |     P=0.077N     P=0.664      P=0.213N     P=0.215N    |(e)          (e)          (e)          (e)          |
|LOGISTIC REGRESSION|     P=0.058N     P=0.645      (e)          (e)         |(e)          (e)          (e)          (e)          |
|COCH-ARM / FISHERS |     P=0.086N     P=0.684N     P=0.242N     P=0.247N    |(e)          (e)          (e)          (e)          |
|=================================================================================================================================|
       Date:  07/13/98                           EXPERIMENT: 05184 TEST: 06                                            Page 10
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                   GLUTARALDEHYDE
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      62.5 PPB     125 PPB      250 PPB     |CONTROL      62.5 PPB     125 PPB      250 PPB      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Liver                                                                                                                            |
|     Necrosis                                                                                                                    |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     1/49 (2%)    1/50 (2%)    0/50 (0%)    2/49 (4%)   |1/50 (2%)    1/48 (2%)    1/50 (2%)    2/50 (4%)    |
|POLY-3 ADJUSTED (b)|     2.4%         2.5%         0.0%         4.4%        |2.2%         2.2%         2.2%         4.6%         |
|TERMINAL (d)       |     0/31 (0%)    0/27 (0%)    0/40 (0%)    0/38 (0%)   |0/34 (0%)    0/37 (0%)    0/35 (0%)    2/32 (6%)    |
|FIRST INCIDENCE    |     684          598          ---          558         |681          527          570          735 (T)      |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.412      P=0.734      P=0.475N     P=0.539     |P=0.334      P=0.755N     P=0.753N     P=0.483      |
|POLY 3             |     P=0.389      P=0.751      P=0.487N     P=0.526     |P=0.343      P=0.757N     P=0.753N     P=0.491      |
|POLY 1.5           |     P=0.379      P=0.757      P=0.492N     P=0.516     |P=0.349      P=0.759      P=0.755N     P=0.495      |
|POLY 6             |     P=0.401      P=0.745      P=0.480N     P=0.539     |P=0.335      P=0.752N     P=0.751N     P=0.485      |
|LOGISTIC REGRESSION|     P=0.324      P=0.743N     P=0.498N     P=0.466     |P=0.362      P=0.683      P=0.713      P=0.492      |
|COCH-ARM / FISHERS |     P=0.364      P=0.747N     P=0.495N     P=0.500     |P=0.356      P=0.742      P=0.753N     P=0.500      |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      62.5 PPB     125 PPB      250 PPB     |CONTROL      62.5 PPB     125 PPB      250 PPB      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Liver: Centrilobular                                                                                                             |
|     Necrosis                                                                                                                    |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     0/49 (0%)    2/50 (4%)    0/50 (0%)    1/49 (2%)   |1/50 (2%)    0/48 (0%)    2/50 (4%)    1/50 (2%)    |
|POLY-3 ADJUSTED (b)|     0.0%         4.9%         0.0%         2.2%        |2.2%         0.0%         4.3%         2.3%         |
|TERMINAL (d)       |     0/31 (0%)    0/27 (0%)    0/40 (0%)    0/38 (0%)   |1/34 (3%)    0/37 (0%)    0/35 (0%)    0/32 (0%)    |
|FIRST INCIDENCE    |     ---          539          ---          672         |735 (T)      ---          687          588          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.580      P=0.226      (e)          P=0.515     |P=0.485      P=0.483N     P=0.519      P=0.749      |
|POLY 3             |     P=0.560      P=0.229      (e)          P=0.514     |P=0.489      P=0.499N     P=0.512      P=0.758      |
|POLY 1.5           |     P=0.551      P=0.234      (e)          P=0.508     |P=0.495      P=0.502N     P=0.508      P=0.759      |
|POLY 6             |     P=0.570      P=0.224      (e)          P=0.522     |P=0.482      P=0.494N     P=0.516      P=0.758      |
|LOGISTIC REGRESSION|     P=0.507      P=0.262      (e)          P=0.488     |P=0.511      (e)          P=0.506      P=0.763      |
|COCH-ARM / FISHERS |     P=0.538      P=0.253      (e)          P=0.500     |P=0.504      P=0.510N     P=0.500      P=0.753N     |
|=================================================================================================================================|
       Date:  07/13/98                           EXPERIMENT: 05184 TEST: 06                                            Page 11
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                   GLUTARALDEHYDE
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      62.5 PPB     125 PPB      250 PPB     |CONTROL      62.5 PPB     125 PPB      250 PPB      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Lung                                                                                                                             |
|     Thrombosis                                                                                                                  |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     0/48 (0%)    0/50 (0%)    0/50 (0%)    0/50 (0%)   |1/50 (2%)    0/49 (0%)    2/50 (4%)    0/50 (0%)    |
|POLY-3 ADJUSTED (b)|     0.0%         0.0%         0.0%         0.0%        |2.2%         0.0%         4.3%         0.0%         |
|TERMINAL (d)       |     0/31 (0%)    0/27 (0%)    0/40 (0%)    0/38 (0%)   |1/34 (3%)    0/37 (0%)    0/35 (0%)    0/32 (0%)    |
|FIRST INCIDENCE    |     ---          ---          ---          ---         |735 (T)      ---          687          ---          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     (e)          (e)          (e)          (e)         |P=0.474N     P=0.483N     P=0.519      P=0.512N     |
|POLY 3             |     (e)          (e)          (e)          (e)         |P=0.472N     P=0.498N     P=0.512      P=0.504N     |
|POLY 1.5           |     (e)          (e)          (e)          (e)         |P=0.466N     P=0.500N     P=0.508      P=0.502N     |
|POLY 6             |     (e)          (e)          (e)          (e)         |P=0.479N     P=0.494N     P=0.516      P=0.507N     |
|LOGISTIC REGRESSION|     (e)          (e)          (e)          (e)         |P=0.463N     (e)          P=0.506      (e)          |
|COCH-ARM / FISHERS |     (e)          (e)          (e)          (e)         |P=0.459N     P=0.505N     P=0.500      P=0.500N     |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      62.5 PPB     125 PPB      250 PPB     |CONTROL      62.5 PPB     125 PPB      250 PPB      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Lung: Alveolar Epithelium                                                                                                        |
|     Hyperplasia                                                                                                                 |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     3/48 (6%)    3/50 (6%)    5/50 (10%)   2/50 (4%)   |4/50 (8%)    4/49 (8%)    0/50 (0%)    0/50 (0%)    |
|POLY-3 ADJUSTED (b)|     7.2%         7.5%         11.1%        4.4%        |9.0%         8.9%         0.0%         0.0%         |
|TERMINAL (d)       |     3/31 (10%)   2/27 (7%)    5/40 (13%)   2/38 (5%)   |3/34 (9%)    4/37 (11%)   0/35 (0%)    0/32 (0%)    |
|FIRST INCIDENCE    |     733 (T)      685          733 (T)      733 (T)     |734          735 (T)      ---          ---          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.301N     P=0.602      P=0.502      P=0.407N    |P=0.016N*    P=0.598N     P=0.062N     P=0.074N     |
|POLY 3             |     P=0.377N     P=0.646      P=0.399      P=0.460N    |P=0.013N*    P=0.637N     P=0.057N     P=0.063N     |
|POLY 1.5           |     P=0.396N     P=0.660      P=0.388      P=0.469N    |P=0.013N*    P=0.643      P=0.058N     P=0.062N     |
|POLY 6             |     P=0.355N     P=0.630      P=0.419      P=0.449N    |P=0.013N*    P=0.627N     P=0.056N     P=0.064N     |
|LOGISTIC REGRESSION|     P=0.337N     P=0.615      P=0.502      P=0.407N    |P=0.015N*    P=0.605N     P=0.059N     P=0.069N     |
|COCH-ARM / FISHERS |     P=0.424N     P=0.641N     P=0.381      P=0.480N    |P=0.014N*    P=0.631      P=0.059N     P=0.059N     |
|=================================================================================================================================|
       Date:  07/13/98                           EXPERIMENT: 05184 TEST: 06                                            Page 12
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                   GLUTARALDEHYDE
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      62.5 PPB     125 PPB      250 PPB     |CONTROL      62.5 PPB     125 PPB      250 PPB      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Lymph Node, Bronchial                                                                                                            |
|     Infiltration Cellular Plasma Cell                                                                                           |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     0/34 (0%)    0/28 (0%)    0/35 (0%)    0/37 (0%)   |2/29 (7%)    0/32 (0%)    0/37 (0%)    0/36 (0%)    |
|POLY-3 ADJUSTED (b)|     0.0%         0.0%         0.0%         0.0%        |7.5%         0.0%         0.0%         0.0%         |
|TERMINAL (d)       |     0/24 (0%)    0/17 (0%)    0/30 (0%)    0/31 (0%)   |0/19 (0%)    0/25 (0%)    0/25 (0%)    0/23 (0%)    |
|FIRST INCIDENCE    |     ---          ---          ---          ---         |507          ---          ---          ---          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     (e)          (e)          (e)          (e)         |P=0.118N     P=0.237N     P=0.232N     P=0.250N     |
|POLY 3             |     (e)          (e)          (e)          (e)         |P=0.089N     P=0.210N     P=0.186N     P=0.200N     |
|POLY 1.5           |     (e)          (e)          (e)          (e)         |P=0.090N     P=0.211N     P=0.183N     P=0.194N     |
|POLY 6             |     (e)          (e)          (e)          (e)         |P=0.089N     P=0.210N     P=0.190N     P=0.208N     |
|LOGISTIC REGRESSION|     (e)          (e)          (e)          (e)         |P=0.116N     P=0.294N     P=0.255N     P=0.210N     |
|COCH-ARM / FISHERS |     (e)          (e)          (e)          (e)         |P=0.093N     P=0.222N     P=0.189N     P=0.195N     |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      62.5 PPB     125 PPB      250 PPB     |CONTROL      62.5 PPB     125 PPB      250 PPB      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Lymph Node, Mesenteric                                                                                                           |
|     Hyperplasia Lymphoid                                                                                                        |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     0/46 (0%)    0/44 (0%)    0/47 (0%)    0/47 (0%)   |4/47 (9%)    0/48 (0%)    1/46 (2%)    0/46 (0%)    |
|POLY-3 ADJUSTED (b)|     0.0%         0.0%         0.0%         0.0%        |9.4%         0.0%         2.4%         0.0%         |
|TERMINAL (d)       |     0/31 (0%)    0/25 (0%)    0/38 (0%)    0/36 (0%)   |4/33 (12%)   0/37 (0%)    1/33 (3%)    0/30 (0%)    |
|FIRST INCIDENCE    |     ---          ---          ---          ---         |735 (T)      ---          735 (T)      ---          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     (e)          (e)          (e)          (e)         |P=0.045N*    P=0.049N*    P=0.178N     P=0.075N     |
|POLY 3             |     (e)          (e)          (e)          (e)         |P=0.041N*    P=0.053N     P=0.177N     P=0.067N     |
|POLY 1.5           |     (e)          (e)          (e)          (e)         |P=0.040N*    P=0.054N     P=0.179N     P=0.065N     |
|POLY 6             |     (e)          (e)          (e)          (e)         |P=0.042N*    P=0.051N     P=0.175N     P=0.069N     |
|LOGISTIC REGRESSION|     (e)          (e)          (e)          (e)         |P=0.045N*    (e)          P=0.178N     (e)          |
|COCH-ARM / FISHERS |     (e)          (e)          (e)          (e)         |P=0.041N*    P=0.056N     P=0.187N     P=0.061N     |
|=================================================================================================================================|
       Date:  07/13/98                           EXPERIMENT: 05184 TEST: 06                                            Page 13
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                   GLUTARALDEHYDE
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      62.5 PPB     125 PPB      250 PPB     |CONTROL      62.5 PPB     125 PPB      250 PPB      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Mesentery: Artery                                                                                                                |
|     Inflammation Chronic                                                                                                        |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     0/2 (0%)     0/2 (0%)     0/3 (0%)     0/5 (0%)    |2/12 (17%)   0/6 (0%)     0/5 (0%)     0/6 (0%)     |
|POLY-3 ADJUSTED (b)|     0.0%         0.0%         0.0%         0.0%        |18.4%        0.0%         0.0%         0.0%         |
|TERMINAL (d)       |     0/1 (0%)     0/1 (0%)     0/1 (0%)     0/3 (0%)    |0/6 (0%)     0/4 (0%)     0/3 (0%)     0/2 (0%)     |
|FIRST INCIDENCE    |     ---          ---          ---          ---         |507          ---          ---          ---          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     (e)          (e)          (e)          (e)         |P=0.119N     P=0.247N     P=0.240N     P=0.252N     |
|POLY 3             |     (e)          (e)          (e)          (e)         |P=0.205N     P=0.396N     P=0.455N     P=0.386N     |
|POLY 1.5           |     (e)          (e)          (e)          (e)         |P=0.204N     P=0.397N     P=0.451N     P=0.391N     |
|POLY 6             |     (e)          (e)          (e)          (e)         |P=0.206N     P=0.393N     P=0.458N     P=0.381N     |
|LOGISTIC REGRESSION|     (e)          (e)          (e)          (e)         |(e)          (e)          (e)          (e)          |
|COCH-ARM / FISHERS |     (e)          (e)          (e)          (e)         |P=0.198N     P=0.431N     P=0.485N     P=0.431N     |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      62.5 PPB     125 PPB      250 PPB     |CONTROL      62.5 PPB     125 PPB      250 PPB      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Mesentery: Fat                                                                                                                   |
|     Necrosis                                                                                                                    |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     1/2 (50%)    2/2 (100%)   2/3 (67%)    5/5 (100%)  |9/12 (75%)   5/6 (83%)    3/5 (60%)    4/6 (67%)    |
|POLY-3 ADJUSTED (b)|     55.2%        100.0%       66.7%        100.0%      |84.1%        84.8%        69.0%        68.7%        |
|TERMINAL (d)       |     1/1 (100%)   1/1 (100%)   0/1 (0%)     3/3 (100%)  |5/6 (83%)    4/4 (100%)   3/3 (100%)   2/2 (100%)   |
|FIRST INCIDENCE    |     733 (T)      685          504          672         |614          610          735 (T)      707          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.192      P=0.480      P=0.546      P=0.256     |P=0.417N     P=0.300N     P=0.142N     P=0.438N     |
|POLY 3             |     P=0.262      P=0.569      P=0.715      P=0.380     |P=0.302N     P=0.758      P=0.522N     P=0.459N     |
|POLY 1.5           |     P=0.234      P=0.533      P=0.693      P=0.329     |P=0.339N     P=0.685      P=0.496N     P=0.504N     |
|POLY 6             |     P=0.317      P=0.650      P=0.755      P=0.507     |P=0.279N     P=0.764N     P=0.593N     P=0.430N     |
|LOGISTIC REGRESSION|     P=0.200      (e)          P=0.787      P=0.265     |P=0.142N     P=0.735N     P=0.338N     P=0.291N     |
|COCH-ARM / FISHERS |     P=0.202      P=0.500      P=0.700      P=0.286     |P=0.396N     P=0.593      P=0.472N     P=0.561N     |
|=================================================================================================================================|
       Date:  07/13/98                           EXPERIMENT: 05184 TEST: 06                                            Page 14
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                   GLUTARALDEHYDE
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      62.5 PPB     125 PPB      250 PPB     |CONTROL      62.5 PPB     125 PPB      250 PPB      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Nose                                                                                                                             |
|     Inflammation                                                                                                                |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     6/48 (13%)   4/50 (8%)    3/50 (6%)    5/50 (10%)  |6/50 (12%)   7/49 (14%)   13/50 (26%)  14/50 (28%)  |
|POLY-3 ADJUSTED (b)|     14.2%        9.8%         6.5%         11.0%       |13.3%        15.5%        27.7%        30.0%        |
|TERMINAL (d)       |     5/31 (16%)   3/27 (11%)   1/40 (3%)    4/38 (11%)  |3/34 (9%)    6/37 (16%)   7/35 (20%)   4/32 (13%)   |
|FIRST INCIDENCE    |     516          476          516          723         |664          708          666          502          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.325N     P=0.443N     P=0.171N     P=0.372N    |P=0.015 *    P=0.564      P=0.091      P=0.048 *    |
|POLY 3             |     P=0.405N     P=0.394N     P=0.201N     P=0.448N    |P=0.018 *    P=0.501      P=0.072      P=0.043 *    |
|POLY 1.5           |     P=0.422N     P=0.373N     P=0.212N     P=0.458N    |P=0.017 *    P=0.496      P=0.068      P=0.041 *    |
|POLY 6             |     P=0.385N     P=0.418N     P=0.183N     P=0.436N    |P=0.020 *    P=0.508      P=0.076      P=0.047 *    |
|LOGISTIC REGRESSION|     P=0.449N     P=0.356N     P=0.227N     P=0.444N    |P=0.017 *    P=0.511      P=0.067      P=0.041 *    |
|COCH-ARM / FISHERS |     P=0.445N     P=0.344N     P=0.223N     P=0.471N    |P=0.017 *    P=0.484      P=0.062      P=0.039 *    |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      62.5 PPB     125 PPB      250 PPB     |CONTROL      62.5 PPB     125 PPB      250 PPB      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Nose: Olfactory Epithelium                                                                                                       |
|     Atrophy                                                                                                                     |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     1/48 (2%)    1/50 (2%)    0/50 (0%)    2/50 (4%)   |0/50 (0%)    1/49 (2%)    3/50 (6%)    3/50 (6%)    |
|POLY-3 ADJUSTED (b)|     2.4%         2.5%         0.0%         4.4%        |0.0%         2.2%         6.4%         6.9%         |
|TERMINAL (d)       |     1/31 (3%)    0/27 (0%)    0/40 (0%)    1/38 (3%)   |0/34 (0%)    1/37 (3%)    0/35 (0%)    3/32 (9%)    |
|FIRST INCIDENCE    |     733 (T)      706          ---          723         |---          735 (T)      502          735 (T)      |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.442      P=0.735      P=0.449N     P=0.570     |P=0.058      P=0.517      P=0.132      P=0.110      |
|POLY 3             |     P=0.395      P=0.752      P=0.485N     P=0.531     |P=0.063      P=0.502      P=0.129      P=0.115      |
|POLY 1.5           |     P=0.387      P=0.759      P=0.489N     P=0.524     |P=0.065      P=0.500      P=0.126      P=0.117      |
|POLY 6             |     P=0.404      P=0.744      P=0.478N     P=0.539     |P=0.060      P=0.506      P=0.133      P=0.112      |
|LOGISTIC REGRESSION|     P=0.414      P=0.744      (e)          P=0.550     |P=0.073      P=0.517      P=0.056      P=0.110      |
|COCH-ARM / FISHERS |     P=0.375      P=0.742N     P=0.490N     P=0.515     |P=0.069      P=0.495      P=0.121      P=0.121      |
|=================================================================================================================================|
       Date:  07/13/98                           EXPERIMENT: 05184 TEST: 06                                            Page 15
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                   GLUTARALDEHYDE
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      62.5 PPB     125 PPB      250 PPB     |CONTROL      62.5 PPB     125 PPB      250 PPB      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Nose: Olfactory Epithelium                                                                                                       |
|     Degeneration Hyaline                                                                                                        |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     1/48 (2%)    1/50 (2%)    5/50 (10%)   2/50 (4%)   |11/50 (22%)  10/49 (20%)  15/50 (30%)  10/50 (20%)  |
|POLY-3 ADJUSTED (b)|     2.4%         2.5%         11.1%        4.3%        |24.6%        22.1%        32.4%        22.1%        |
|TERMINAL (d)       |     1/31 (3%)    0/27 (0%)    4/40 (10%)   1/38 (3%)   |10/34 (29%)  7/37 (19%)   12/35 (34%)  7/32 (22%)   |
|FIRST INCIDENCE    |     733 (T)      706          715          589         |708          708          672          401          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.409      P=0.735      P=0.172      P=0.557     |P=0.483      P=0.410N     P=0.280      P=0.550N     |
|POLY 3             |     P=0.370      P=0.752      P=0.120      P=0.535     |P=0.513N     P=0.486N     P=0.276      P=0.489N     |
|POLY 1.5           |     P=0.347      P=0.759      P=0.115      P=0.526     |P=0.508N     P=0.499N     P=0.268      P=0.489N     |
|POLY 6             |     P=0.399      P=0.744      P=0.129      P=0.545     |P=0.524N     P=0.464N     P=0.285      P=0.490N     |
|LOGISTIC REGRESSION|     P=0.347      P=0.744      P=0.142      P=0.506     |P=0.543      P=0.434N     P=0.277      P=0.509N     |
|COCH-ARM / FISHERS |     P=0.314      P=0.742N     P=0.112      P=0.515     |P=0.515N     P=0.521N     P=0.247      P=0.500N     |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      62.5 PPB     125 PPB      250 PPB     |CONTROL      62.5 PPB     125 PPB      250 PPB      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Nose: Respiratory Epithelium                                                                                                     |
|     Degeneration Hyaline                                                                                                        |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     5/48 (10%)   3/50 (6%)    6/50 (12%)   10/50 (20%) |16/50 (32%)  35/49 (71%)  32/50 (64%)  30/50 (60%)  |
|POLY-3 ADJUSTED (b)|     11.8%        7.5%         13.3%        21.5%       |35.8%        72.6%        67.3%        60.9%        |
|TERMINAL (d)       |     3/31 (10%)   3/27 (11%)   6/40 (15%)   8/38 (21%)  |15/34 (44%)  27/37 (73%)  25/35 (71%)  16/32 (50%)  |
|FIRST INCIDENCE    |     602          733 (T)      733 (T)      558         |708          463          524          401          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.104      P=0.436N     P=0.601N     P=0.225     |P=0.017 *    P<0.001 **   P=0.002 **   P=0.006 **   |
|POLY 3             |     P=0.063      P=0.388N     P=0.543      P=0.176     |P=0.071      P<0.001 **   P<0.001 **   P=0.011 *    |
|POLY 1.5           |     P=0.054      P=0.365N     P=0.534      P=0.165     |P=0.048 *    P<0.001 **   P<0.001 **   P=0.007 **   |
|POLY 6             |     P=0.074      P=0.417N     P=0.559      P=0.188     |P=0.112      P<0.001 **   P=0.002 **   P=0.017 *    |
|LOGISTIC REGRESSION|     P=0.060      P=0.384N     P=0.555      P=0.151     |P=0.027 *    P<0.001 **   P=0.002 **   P=0.005 **   |
|COCH-ARM / FISHERS |     P=0.044 *    P=0.335N     P=0.529      P=0.150     |P=0.028 *    P<0.001 **   P<0.001 **   P=0.004 **   |
|=================================================================================================================================|
       Date:  07/13/98                           EXPERIMENT: 05184 TEST: 06                                            Page 16
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                   GLUTARALDEHYDE
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      62.5 PPB     125 PPB      250 PPB     |CONTROL      62.5 PPB     125 PPB      250 PPB      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Nose: Respiratory Epithelium                                                                                                     |
|     Metaplasia                                                                                                                  |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     2/48 (4%)    5/50 (10%)   6/50 (12%)   9/50 (18%)  |7/50 (14%)   11/49 (22%)  16/50 (32%)  21/50 (42%)  |
|POLY-3 ADJUSTED (b)|     4.8%         12.0%        13.1%        19.3%       |15.5%        24.2%        33.2%        44.6%        |
|TERMINAL (d)       |     2/31 (7%)    2/27 (7%)    4/40 (10%)   4/38 (11%)  |4/34 (12%)   10/37 (27%)  9/35 (26%)   9/32 (28%)   |
|FIRST INCIDENCE    |     733 (T)      402          516          589         |664          672          502          502          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.057      P=0.182      P=0.218      P=0.059     |P<0.001 **   P=0.282      P=0.048 *    P=0.004 **   |
|POLY 3             |     P=0.033 *    P=0.215      P=0.164      P=0.040 *   |P<0.001 **   P=0.217      P=0.038 *    P=0.002 **   |
|POLY 1.5           |     P=0.027 *    P=0.223      P=0.155      P=0.035 *   |P<0.001 **   P=0.213      P=0.034 *    P<0.001 **   |
|POLY 6             |     P=0.040 *    P=0.207      P=0.180      P=0.046 *   |P<0.001 **   P=0.224      P=0.043 *    P=0.002 **   |
|LOGISTIC REGRESSION|     P=0.019 *    P=0.266      P=0.151      P=0.033 *   |P<0.001 **   P=0.228      P=0.026 *    P=0.002 **   |
|COCH-ARM / FISHERS |     P=0.022 *    P=0.235      P=0.148      P=0.030 *   |P<0.001 **   P=0.204      P=0.028 *    P=0.002 **   |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      62.5 PPB     125 PPB      250 PPB     |CONTROL      62.5 PPB     125 PPB      250 PPB      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Nose: Turbinate                                                                                                                  |
|     Necrosis                                                                                                                    |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     0/48 (0%)    0/50 (0%)    2/50 (4%)    0/50 (0%)   |0/50 (0%)    3/49 (6%)    1/50 (2%)    4/50 (8%)    |
|POLY-3 ADJUSTED (b)|     0.0%         0.0%         4.4%         0.0%        |0.0%         6.6%         2.2%         8.8%         |
|TERMINAL (d)       |     0/31 (0%)    0/27 (0%)    1/40 (3%)    0/38 (0%)   |0/34 (0%)    2/37 (5%)    0/35 (0%)    1/32 (3%)    |
|FIRST INCIDENCE    |     ---          ---          516          ---         |---          708          704          502          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.625      (e)          P=0.265      (e)         |P=0.064      P=0.141      P=0.511      P=0.061      |
|POLY 3             |     P=0.639      (e)          P=0.258      (e)         |P=0.074      P=0.121      P=0.506      P=0.062      |
|POLY 1.5           |     P=0.624      (e)          P=0.252      (e)         |P=0.074      P=0.119      P=0.504      P=0.062      |
|POLY 6             |     P=0.656      (e)          P=0.267      (e)         |P=0.075      P=0.125      P=0.508      P=0.063      |
|LOGISTIC REGRESSION|     P=0.576      (e)          P=0.247      (e)         |P=0.078      P=0.125      P=0.500      P=0.053      |
|COCH-ARM / FISHERS |     P=0.602      (e)          P=0.258      (e)         |P=0.073      P=0.117      P=0.500      P=0.059      |
|=================================================================================================================================|
       Date:  07/13/98                           EXPERIMENT: 05184 TEST: 06                                            Page 17
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                   GLUTARALDEHYDE
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      62.5 PPB     125 PPB      250 PPB     |CONTROL      62.5 PPB     125 PPB      250 PPB      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Ovary                                                                                                                            |
|     Cyst                                                                                                                        |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |                                                        |16/49 (33%)  12/47 (26%)  18/49 (37%)  18/50 (36%)  |
|POLY-3 ADJUSTED (b)|                                                        |35.8%        27.2%        38.8%        40.0%        |
|TERMINAL (d)       |                                                        |13/34 (38%)  11/36 (31%)  13/35 (37%)  14/32 (44%)  |
|FIRST INCIDENCE    |                                                        |532          672          524          502          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |                                                        |P=0.169      P=0.197N     P=0.462      P=0.351      |
|POLY 3             |                                                        |P=0.247      P=0.259N     P=0.469      P=0.425      |
|POLY 1.5           |                                                        |P=0.262      P=0.270N     P=0.453      P=0.437      |
|POLY 6             |                                                        |P=0.230      P=0.244N     P=0.486      P=0.411      |
|LOGISTIC REGRESSION|                                                        |P=0.243      P=0.240N     P=0.450      P=0.419      |
|COCH-ARM / FISHERS |                                                        |P=0.277      P=0.294N     P=0.416      P=0.445      |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      62.5 PPB     125 PPB      250 PPB     |CONTROL      62.5 PPB     125 PPB      250 PPB      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Pancreas: Duct                                                                                                                   |
|     Cyst                                                                                                                        |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     0/47 (0%)    0/49 (0%)    1/50 (2%)    0/48 (0%)   |1/50 (2%)    0/48 (0%)    2/49 (4%)    0/49 (0%)    |
|POLY-3 ADJUSTED (b)|     0.0%         0.0%         2.2%         0.0%        |2.2%         0.0%         4.4%         0.0%         |
|TERMINAL (d)       |     0/31 (0%)    0/27 (0%)    1/40 (3%)    0/38 (0%)   |1/34 (3%)    0/37 (0%)    2/35 (6%)    0/32 (0%)    |
|FIRST INCIDENCE    |     ---          ---          733 (T)      ---         |735 (T)      ---          735 (T)      ---          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.728      (e)          P=0.551      (e)         |P=0.483N     P=0.483N     P=0.510      P=0.512N     |
|POLY 3             |     P=0.733      (e)          P=0.519      (e)         |P=0.477N     P=0.499N     P=0.504      P=0.507N     |
|POLY 1.5           |     P=0.720      (e)          P=0.515      (e)         |P=0.471N     P=0.502N     P=0.501      P=0.506N     |
|POLY 6             |     P=0.746      (e)          P=0.526      (e)         |P=0.483N     P=0.494N     P=0.507      P=0.509N     |
|LOGISTIC REGRESSION|     (e)          (e)          P=0.551      (e)         |P=0.483N     (e)          P=0.510      (e)          |
|COCH-ARM / FISHERS |     P=0.698      (e)          P=0.515      (e)         |P=0.463N     P=0.510N     P=0.492      P=0.505N     |
|=================================================================================================================================|
       Date:  07/13/98                           EXPERIMENT: 05184 TEST: 06                                            Page 18
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                   GLUTARALDEHYDE
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      62.5 PPB     125 PPB      250 PPB     |CONTROL      62.5 PPB     125 PPB      250 PPB      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Pituitary Gland: Pars Distalis                                                                                                   |
|     Hyperplasia                                                                                                                 |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     2/46 (4%)    1/47 (2%)    2/48 (4%)    4/47 (9%)   |19/49 (39%)  24/49 (49%)  23/49 (47%)  28/50 (56%)  |
|POLY-3 ADJUSTED (b)|     5.0%         2.6%         4.7%         9.1%        |41.6%        50.6%        49.2%        61.1%        |
|TERMINAL (d)       |     1/30 (3%)    1/27 (4%)    2/38 (5%)    4/37 (11%)  |14/34 (41%)  18/37 (49%)  16/35 (46%)  20/32 (63%)  |
|FIRST INCIDENCE    |     684          733 (T)      733 (T)      733 (T)     |507          463          570          502          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.248      P=0.541N     P=0.617N     P=0.425     |P=0.037 *    P=0.329      P=0.334      P=0.046 *    |
|POLY 3             |     P=0.200      P=0.517N     P=0.667N     P=0.381     |P=0.046 *    P=0.253      P=0.299      P=0.045 *    |
|POLY 1.5           |     P=0.188      P=0.507N     P=0.674N     P=0.368     |P=0.055      P=0.238      P=0.293      P=0.052      |
|POLY 6             |     P=0.213      P=0.527N     P=0.656N     P=0.393     |P=0.038 *    P=0.274      P=0.305      P=0.038 *    |
|LOGISTIC REGRESSION|     P=0.225      P=0.522N     P=0.660N     P=0.400     |P=0.060      P=0.211      P=0.293      P=0.052      |
|COCH-ARM / FISHERS |     P=0.168      P=0.492N     P=0.675N     P=0.349     |P=0.069      P=0.208      P=0.270      P=0.065      |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      62.5 PPB     125 PPB      250 PPB     |CONTROL      62.5 PPB     125 PPB      250 PPB      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Preputial Gland                                                                                                                  |
|     Inflammation Chronic                                                                                                        |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     2/48 (4%)    2/49 (4%)    2/50 (4%)    0/47 (0%)   |                                                    |
|POLY-3 ADJUSTED (b)|     4.8%         5.1%         4.4%         0.0%        |                                                    |
|TERMINAL (d)       |     1/31 (3%)    1/27 (4%)    2/40 (5%)    0/36 (0%)   |                                                    |
|FIRST INCIDENCE    |     716          588          733 (T)      ---         |                                                    |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.123N     P=0.649      P=0.603N     P=0.206N    |                                                    |
|POLY 3             |     P=0.150N     P=0.675      P=0.667N     P=0.231N    |                                                    |
|POLY 1.5           |     P=0.157N     P=0.685      P=0.674N     P=0.235N    |                                                    |
|POLY 6             |     P=0.142N     P=0.664      P=0.655N     P=0.226N    |                                                    |
|LOGISTIC REGRESSION|     P=0.154N     P=0.689      P=0.641N     P=0.223N    |                                                    |
|COCH-ARM / FISHERS |     P=0.166N     P=0.684N     P=0.676N     P=0.253N    |                                                    |
|=================================================================================================================================|
       Date:  07/13/98                           EXPERIMENT: 05184 TEST: 06                                            Page 19
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                   GLUTARALDEHYDE
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      62.5 PPB     125 PPB      250 PPB     |CONTROL      62.5 PPB     125 PPB      250 PPB      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Skin: Prepuce                                                                                                                    |
|     Inflammation Chronic                                                                                                        |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     6/48 (13%)   7/50 (14%)   4/50 (8%)    5/48 (10%)  |0/50 (0%)    0/50 (0%)    0/50 (0%)    0/50 (0%)    |
|POLY-3 ADJUSTED (b)|     13.7%        16.3%        8.9%         10.9%       |0.0%         0.0%         0.0%         0.0%         |
|TERMINAL (d)       |     2/31 (7%)    2/27 (7%)    2/40 (5%)    1/37 (3%)   |0/34 (0%)    0/37 (0%)    0/35 (0%)    0/32 (0%)    |
|FIRST INCIDENCE    |     359          420          702          327         |---          ---          ---          ---          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.267N     P=0.441      P=0.280N     P=0.439N    |(e)          (e)          (e)          (e)          |
|POLY 3             |     P=0.314N     P=0.487      P=0.348N     P=0.463N    |(e)          (e)          (e)          (e)          |
|POLY 1.5           |     P=0.332N     P=0.503      P=0.351N     P=0.478N    |(e)          (e)          (e)          (e)          |
|POLY 6             |     P=0.294N     P=0.469      P=0.337N     P=0.446N    |(e)          (e)          (e)          (e)          |
|LOGISTIC REGRESSION|     P=0.484N     P=0.556N     P=0.350N     P=0.613     |(e)          (e)          (e)          (e)          |
|COCH-ARM / FISHERS |     P=0.356N     P=0.532      P=0.344N     P=0.500N    |(e)          (e)          (e)          (e)          |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      62.5 PPB     125 PPB      250 PPB     |CONTROL      62.5 PPB     125 PPB      250 PPB      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Spleen                                                                                                                           |
|     Hematopoietic Cell Proliferation                                                                                            |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     12/48 (25%)  14/48 (29%)  12/50 (24%)  7/48 (15%)  |11/50 (22%)  8/48 (17%)   8/48 (17%)   12/49 (24%)  |
|POLY-3 ADJUSTED (b)|     27.0%        30.9%        25.5%        14.9%       |22.9%        17.1%        17.6%        26.2%        |
|TERMINAL (d)       |     2/31 (7%)    1/27 (4%)    8/40 (20%)   1/38 (3%)   |2/34 (6%)    3/37 (8%)    4/35 (11%)   3/32 (9%)    |
|FIRST INCIDENCE    |     532          402          492          504         |248          492          570          401          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.055N     P=0.335      P=0.425N     P=0.121N    |P=0.335      P=0.280N     P=0.296N     P=0.472      |
|POLY 3             |     P=0.062N     P=0.431      P=0.529N     P=0.123N    |P=0.325      P=0.329N     P=0.354N     P=0.444      |
|POLY 1.5           |     P=0.070N     P=0.425      P=0.539N     P=0.132N    |P=0.338      P=0.334N     P=0.349N     P=0.457      |
|POLY 6             |     P=0.056N     P=0.433      P=0.516N     P=0.114N    |P=0.313      P=0.322N     P=0.360N     P=0.434      |
|LOGISTIC REGRESSION|     P=0.229N     P=0.595      P=0.568N     P=0.303N    |P=0.451      P=0.513N     P=0.461N     P=0.539      |
|COCH-ARM / FISHERS |     P=0.085N     P=0.409      P=0.547N     P=0.153N    |P=0.359      P=0.341N     P=0.341N     P=0.478      |
|=================================================================================================================================|
       Date:  07/13/98                           EXPERIMENT: 05184 TEST: 06                                            Page 20
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                   GLUTARALDEHYDE
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      62.5 PPB     125 PPB      250 PPB     |CONTROL      62.5 PPB     125 PPB      250 PPB      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Spleen                                                                                                                           |
|     Hyperplasia Lymphoid                                                                                                        |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     0/48 (0%)    2/48 (4%)    0/50 (0%)    0/48 (0%)   |4/50 (8%)    2/48 (4%)    1/48 (2%)    0/49 (0%)    |
|POLY-3 ADJUSTED (b)|     0.0%         5.0%         0.0%         0.0%        |9.0%         4.5%         2.2%         0.0%         |
|TERMINAL (d)       |     0/31 (0%)    1/27 (4%)    0/40 (0%)    0/38 (0%)   |4/34 (12%)   2/37 (5%)    1/35 (3%)    0/32 (0%)    |
|FIRST INCIDENCE    |     ---          402          ---          ---         |735 (T)      735 (T)      735 (T)      ---          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.378N     P=0.225      (e)          (e)         |P=0.032N*    P=0.298N     P=0.170N     P=0.070N     |
|POLY 3             |     P=0.397N     P=0.226      (e)          (e)         |P=0.032N*    P=0.334N     P=0.179N     P=0.065N     |
|POLY 1.5           |     P=0.399N     P=0.231      (e)          (e)         |P=0.031N*    P=0.342N     P=0.183N     P=0.064N     |
|POLY 6             |     P=0.395N     P=0.222      (e)          (e)         |P=0.032N*    P=0.324N     P=0.174N     P=0.065N     |
|LOGISTIC REGRESSION|     P=0.495N     P=0.287      (e)          (e)         |P=0.032N*    P=0.298N     P=0.170N     (e)          |
|COCH-ARM / FISHERS |     P=0.404N     P=0.247      (e)          (e)         |P=0.031N*    P=0.359N     P=0.194N     P=0.061N     |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      62.5 PPB     125 PPB      250 PPB     |CONTROL      62.5 PPB     125 PPB      250 PPB      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Stomach, Forestomach                                                                                                             |
|     Hyperplasia                                                                                                                 |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     2/48 (4%)    1/49 (2%)    1/50 (2%)    0/48 (0%)   |1/50 (2%)    0/49 (0%)    1/48 (2%)    1/48 (2%)    |
|POLY-3 ADJUSTED (b)|     4.8%         2.5%         2.2%         0.0%        |2.2%         0.0%         2.2%         2.3%         |
|TERMINAL (d)       |     2/31 (7%)    0/27 (0%)    0/40 (0%)    0/38 (0%)   |1/34 (3%)    0/37 (0%)    0/35 (0%)    1/32 (3%)    |
|FIRST INCIDENCE    |     733 (T)      364          516          ---         |735 (T)      ---          640          735 (T)      |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.132N     P=0.530N     P=0.444N     P=0.195N    |P=0.519      P=0.483N     P=0.752N     P=0.748      |
|POLY 3             |     P=0.138N     P=0.512N     P=0.468N     P=0.221N    |P=0.523      P=0.498N     P=0.759N     P=0.752      |
|POLY 1.5           |     P=0.143N     P=0.504N     P=0.477N     P=0.227N    |P=0.526      P=0.500N     P=0.758      P=0.752      |
|POLY 6             |     P=0.131N     P=0.522N     P=0.454N     P=0.214N    |P=0.519      P=0.494N     P=0.755N     P=0.751      |
|LOGISTIC REGRESSION|     P=0.201N     P=0.434N     P=0.489N     (e)         |P=0.529      (e)          P=0.744      P=0.748      |
|COCH-ARM / FISHERS |     P=0.151N     P=0.492N     P=0.485N     P=0.247N    |P=0.529      P=0.505N     P=0.742      P=0.742      |
|=================================================================================================================================|
       Date:  07/13/98                           EXPERIMENT: 05184 TEST: 06                                            Page 21
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                   GLUTARALDEHYDE
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      62.5 PPB     125 PPB      250 PPB     |CONTROL      62.5 PPB     125 PPB      250 PPB      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Stomach, Forestomach                                                                                                             |
|     Inflammation Acute                                                                                                          |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     2/48 (4%)    1/49 (2%)    0/50 (0%)    0/48 (0%)   |0/50 (0%)    1/49 (2%)    2/48 (4%)    0/48 (0%)    |
|POLY-3 ADJUSTED (b)|     4.8%         2.5%         0.0%         0.0%        |0.0%         2.2%         4.5%         0.0%         |
|TERMINAL (d)       |     1/31 (3%)    0/27 (0%)    0/40 (0%)    0/38 (0%)   |0/34 (0%)    1/37 (3%)    1/35 (3%)    0/32 (0%)    |
|FIRST INCIDENCE    |     626          364          ---          ---         |---          735 (T)      640          ---          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.089N     P=0.525N     P=0.207N     P=0.208N    |P=0.637N     P=0.517      P=0.248      (e)          |
|POLY 3             |     P=0.094N     P=0.516N     P=0.222N     P=0.223N    |P=0.627N     P=0.502      P=0.238      (e)          |
|POLY 1.5           |     P=0.096N     P=0.506N     P=0.225N     P=0.228N    |P=0.625N     P=0.500      P=0.235      (e)          |
|POLY 6             |     P=0.092N     P=0.528N     P=0.216N     P=0.218N    |P=0.629N     P=0.506      P=0.243      (e)          |
|LOGISTIC REGRESSION|     P=0.122N     P=0.405N     P=0.230N     P=0.256N    |P=0.626N     P=0.517      P=0.213      (e)          |
|COCH-ARM / FISHERS |     P=0.099N     P=0.492N     P=0.237N     P=0.247N    |P=0.626N     P=0.495      P=0.237      (e)          |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      62.5 PPB     125 PPB      250 PPB     |CONTROL      62.5 PPB     125 PPB      250 PPB      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Stomach, Glandular                                                                                                               |
|     Infiltration Cellular Mixed Cell                                                                                            |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     0/46 (0%)    2/47 (4%)    0/50 (0%)    0/48 (0%)   |0/50 (0%)    0/48 (0%)    1/48 (2%)    0/48 (0%)    |
|POLY-3 ADJUSTED (b)|     0.0%         5.3%         0.0%         0.0%        |0.0%         0.0%         2.2%         0.0%         |
|TERMINAL (d)       |     0/31 (0%)    2/27 (7%)    0/40 (0%)    0/38 (0%)   |0/34 (0%)    0/37 (0%)    1/35 (3%)    0/32 (0%)    |
|FIRST INCIDENCE    |     ---          733 (T)      ---          ---         |---          ---          735 (T)      ---          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.350N     P=0.208      (e)          (e)         |P=0.686      (e)          P=0.506      (e)          |
|POLY 3             |     P=0.396N     P=0.224      (e)          (e)         |P=0.682      (e)          P=0.500      (e)          |
|POLY 1.5           |     P=0.395N     P=0.231      (e)          (e)         |P=0.686      (e)          P=0.497      (e)          |
|POLY 6             |     P=0.398N     P=0.216      (e)          (e)         |P=0.677      (e)          P=0.502      (e)          |
|LOGISTIC REGRESSION|     (e)          P=0.208      (e)          (e)         |(e)          (e)          P=0.506      (e)          |
|COCH-ARM / FISHERS |     P=0.395N     P=0.253      (e)          (e)         |P=0.690      (e)          P=0.490      (e)          |
|=================================================================================================================================|
       Date:  07/13/98                           EXPERIMENT: 05184 TEST: 06                                            Page 22
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                   GLUTARALDEHYDE
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      62.5 PPB     125 PPB      250 PPB     |CONTROL      62.5 PPB     125 PPB      250 PPB      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Thyroid Gland: Follicular Cell                                                                                                   |
|     Hyperplasia                                                                                                                 |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     14/48 (29%)  9/49 (18%)   11/49 (22%)  19/49 (39%) |26/50 (52%)  24/48 (50%)  30/50 (60%)  37/50 (74%)  |
|POLY-3 ADJUSTED (b)|     33.6%        22.9%        25.0%        42.1%       |56.7%        53.4%        63.8%        82.4%        |
|TERMINAL (d)       |     13/31 (42%)  8/27 (30%)   10/39 (26%)  18/38 (47%) |22/34 (65%)  23/37 (62%)  25/35 (71%)  29/32 (91%)  |
|FIRST INCIDENCE    |     723          723          715          672         |614          714          570          631          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.279      P=0.270N     P=0.122N     P=0.435     |P<0.001 **   P=0.258N     P=0.336      P=0.008 **   |
|POLY 3             |     P=0.124      P=0.204N     P=0.261N     P=0.273     |P=0.002 **   P=0.456N     P=0.311      P=0.004 **   |
|POLY 1.5           |     P=0.103      P=0.183N     P=0.282N     P=0.248     |P=0.003 **   P=0.467N     P=0.304      P=0.008 **   |
|POLY 6             |     P=0.153      P=0.229N     P=0.226N     P=0.310     |P<0.001 **   P=0.443N     P=0.313      P=0.002 **   |
|LOGISTIC REGRESSION|     P=0.209      P=0.256N     P=0.141N     P=0.353     |P<0.001 **   P=0.346N     P=0.331      P=0.004 **   |
|COCH-ARM / FISHERS |     P=0.082      P=0.156N     P=0.300N     P=0.217     |P=0.007 **   P=0.502N     P=0.273      P=0.019 *    |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      62.5 PPB     125 PPB      250 PPB     |CONTROL      62.5 PPB     125 PPB      250 PPB      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Tooth                                                                                                                            |
|     Developmental Malformation                                                                                                  |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     12/13 (92%)  17/17 (100%) 10/10 (100%) 19/19 (100%)|0/0 (0%)     1/1 (100%)   0/0 (0%)     1/1 (100%)   |
|POLY-3 ADJUSTED (b)|     92.3%        100.0%       100.0%       100.0%      |0.0%         100.0%       0.0%         100.0%       |
|TERMINAL (d)       |     9/10 (90%)   14/14 (100%) 9/9 (100%)   17/17 (100%)|0/0 (0%)     1/1 (100%)   0/0 (0%)     1/1 (100%)   |
|FIRST INCIDENCE    |     602          666          504          558         |---          735 (T)      ---          735 (T)      |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.437N     P=0.419      P=0.445N     P=0.648N    |(e)          (e)          (e)          (e)          |
|POLY 3             |     P=0.278      P=0.446      P=0.552      P=0.424     |(e)          (e)          (e)          (e)          |
|POLY 1.5           |     P=0.278      P=0.446      P=0.552      P=0.424     |(e)          (e)          (e)          (e)          |
|POLY 6             |     P=0.278      P=0.446      P=0.552      P=0.424     |(e)          (e)          (e)          (e)          |
|LOGISTIC REGRESSION|     (e)          (e)          (e)          (e)         |(e)          (e)          (e)          (e)          |
|COCH-ARM / FISHERS |     P=0.278      P=0.433      P=0.565      P=0.406     |(e)          (e)          (e)          (e)          |
|=================================================================================================================================|
       Date:  07/13/98                           EXPERIMENT: 05184 TEST: 06                                            Page 23
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                   GLUTARALDEHYDE
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      62.5 PPB     125 PPB      250 PPB     |CONTROL      62.5 PPB     125 PPB      250 PPB      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Tooth                                                                                                                            |
|     Inflammation Chronic                                                                                                        |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     2/13 (15%)   0/17 (0%)    0/10 (0%)    1/19 (5%)   |0/0 (0%)     0/1 (0%)     0/0 (0%)     0/1 (0%)     |
|POLY-3 ADJUSTED (b)|     15.5%        0.0%         0.0%         5.4%        |0.0%         0.0%         0.0%         0.0%         |
|TERMINAL (d)       |     1/10 (10%)   0/14 (0%)    0/9 (0%)     0/17 (0%)   |0/0 (0%)     0/1 (0%)     0/0 (0%)     0/1 (0%)     |
|FIRST INCIDENCE    |     602          ---          ---          723         |---          ---          ---          ---          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.394N     P=0.222N     P=0.246N     P=0.414N    |(e)          (e)          (e)          (e)          |
|POLY 3             |     P=0.387N     P=0.174N     P=0.308N     P=0.373N    |(e)          (e)          (e)          (e)          |
|POLY 1.5           |     P=0.388N     P=0.173N     P=0.302N     P=0.371N    |(e)          (e)          (e)          (e)          |
|POLY 6             |     P=0.385N     P=0.177N     P=0.312N     P=0.375N    |(e)          (e)          (e)          (e)          |
|LOGISTIC REGRESSION|     P=0.367N     P=0.287N     P=0.207N     P=0.358N    |(e)          (e)          (e)          (e)          |
|COCH-ARM / FISHERS |     P=0.389N     P=0.179N     P=0.308N     P=0.356N    |(e)          (e)          (e)          (e)          |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      62.5 PPB     125 PPB      250 PPB     |CONTROL      62.5 PPB     125 PPB      250 PPB      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Urinary Bladder                                                                                                                  |
|     Inflammation Chronic                                                                                                        |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     3/47 (6%)    1/48 (2%)    1/50 (2%)    1/47 (2%)   |0/48 (0%)    0/48 (0%)    0/48 (0%)    0/47 (0%)    |
|POLY-3 ADJUSTED (b)|     7.1%         2.6%         2.2%         2.2%        |0.0%         0.0%         0.0%         0.0%         |
|TERMINAL (d)       |     0/31 (0%)    0/27 (0%)    1/40 (3%)    0/38 (0%)   |0/34 (0%)    0/37 (0%)    0/35 (0%)    0/31 (0%)    |
|FIRST INCIDENCE    |     454          706          733 (T)      504         |---          ---          ---          ---          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.212N     P=0.345N     P=0.274N     P=0.295N    |(e)          (e)          (e)          (e)          |
|POLY 3             |     P=0.214N     P=0.338N     P=0.282N     P=0.283N    |(e)          (e)          (e)          (e)          |
|POLY 1.5           |     P=0.224N     P=0.322N     P=0.285N     P=0.291N    |(e)          (e)          (e)          (e)          |
|POLY 6             |     P=0.204N     P=0.357N     P=0.277N     P=0.276N    |(e)          (e)          (e)          (e)          |
|LOGISTIC REGRESSION|     P=0.322N     P=0.239N     P=0.278N     P=0.629N    |(e)          (e)          (e)          (e)          |
|COCH-ARM / FISHERS |     P=0.240N     P=0.301N     P=0.285N     P=0.308N    |(e)          (e)          (e)          (e)          |
|=================================================================================================================================|
       Date:  07/13/98                           EXPERIMENT: 05184 TEST: 06                                            Page 24
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                   GLUTARALDEHYDE
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      62.5 PPB     125 PPB      250 PPB     |CONTROL      62.5 PPB     125 PPB      250 PPB      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Uterus                                                                                                                           |
|     Angiectasis                                                                                                                 |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |                                                        |2/50 (4%)    1/48 (2%)    1/49 (2%)    0/49 (0%)    |
|POLY-3 ADJUSTED (b)|                                                        |4.5%         2.2%         2.2%         0.0%         |
|TERMINAL (d)       |                                                        |2/34 (6%)    1/37 (3%)    1/35 (3%)    0/32 (0%)    |
|FIRST INCIDENCE    |                                                        |735 (T)      735 (T)      735 (T)      ---          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |                                                        |P=0.163N     P=0.470N     P=0.490N     P=0.252N     |
|POLY 3             |                                                        |P=0.161N     P=0.498N     P=0.496N     P=0.245N     |
|POLY 1.5           |                                                        |P=0.159N     P=0.504N     P=0.499N     P=0.244N     |
|POLY 6             |                                                        |P=0.163N     P=0.490N     P=0.493N     P=0.246N     |
|LOGISTIC REGRESSION|                                                        |P=0.163N     P=0.470N     P=0.490N     (e)          |
|COCH-ARM / FISHERS |                                                        |P=0.155N     P=0.515N     P=0.508N     P=0.253N     |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      62.5 PPB     125 PPB      250 PPB     |CONTROL      62.5 PPB     125 PPB      250 PPB      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Uterus                                                                                                                           |
|     Hydrometra                                                                                                                  |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |                                                        |3/50 (6%)    7/48 (15%)   3/49 (6%)    5/49 (10%)   |
|POLY-3 ADJUSTED (b)|                                                        |6.7%         15.6%        6.6%         11.6%        |
|TERMINAL (d)       |                                                        |2/34 (6%)    7/37 (19%)   3/35 (9%)    4/32 (13%)   |
|FIRST INCIDENCE    |                                                        |614          735 (T)      735 (T)      685          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |                                                        |P=0.412      P=0.189      P=0.649N     P=0.329      |
|POLY 3             |                                                        |P=0.445      P=0.155      P=0.661N     P=0.333      |
|POLY 1.5           |                                                        |P=0.453      P=0.151      P=0.661      P=0.339      |
|POLY 6             |                                                        |P=0.438      P=0.161      P=0.660N     P=0.328      |
|LOGISTIC REGRESSION|                                                        |P=0.433      P=0.162      P=0.663N     P=0.338      |
|COCH-ARM / FISHERS |                                                        |P=0.461      P=0.142      P=0.651      P=0.346      |
|=================================================================================================================================|
       Date:  07/13/98                           EXPERIMENT: 05184 TEST: 06                                            Page 25
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                   GLUTARALDEHYDE
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      62.5 PPB     125 PPB      250 PPB     |CONTROL      62.5 PPB     125 PPB      250 PPB      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Uterus                                                                                                                           |
|     Infiltration Cellular Polymorphonuclear                                                                                     |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |                                                        |3/50 (6%)    1/48 (2%)    0/49 (0%)    1/49 (2%)    |
|POLY-3 ADJUSTED (b)|                                                        |6.5%         2.2%         0.0%         2.3%         |
|TERMINAL (d)       |                                                        |0/34 (0%)    1/37 (3%)    0/35 (0%)    0/32 (0%)    |
|FIRST INCIDENCE    |                                                        |248          735 (T)      ---          701          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |                                                        |P=0.212N     P=0.288N     P=0.120N     P=0.317N     |
|POLY 3             |                                                        |P=0.206N     P=0.314N     P=0.122N     P=0.328N     |
|POLY 1.5           |                                                        |P=0.205N     P=0.317N     P=0.122N     P=0.323N     |
|POLY 6             |                                                        |P=0.208N     P=0.309N     P=0.122N     P=0.333N     |
|LOGISTIC REGRESSION|                                                        |P=0.214N     P=0.464N     P=0.217N     P=0.325N     |
|COCH-ARM / FISHERS |                                                        |P=0.203N     P=0.324N     P=0.125N     P=0.316N     |
|=================================================================================================================================|

(a)  Number of tumor-bearing animals /  number of animals examined at site.
(b)  Poly-3 adjusted lifetime tumor incidence.
(d)  Observed incidence at terminal kill.
(f)  Beneath the control incidence are the P-values associated with the trend 
test.  Beneath the dosed group incidence are the P-values corresponding to 
pairwise comparisons between the controls and that dosed group.  The life
table analysis regards tumors in animals dying prior to  terminal kill as
 being (directly or indirectly) the cause of death.
Logistic regression is an alternative
 method for analyzing the incidence of non-fatal tumors. The Cochran-Armitage
and Fishers exact tests compare directly the overall incidence rates
For all tests a negative trend is indicated by N
(e)  Value of Statistic cannot be computed.
(I)  Interim sacrifice
(T)  Terminal sacrifice
#   Tumor rates based on number of animals necropsied.
*   To the right of any statistical result, indicates significance at (P<=0.05).
**  To the right of any statistical result, indicates significance at (P<=0.01).