TDMS Study 05185-04 Pathology Tables
NTP Experiment-Test: 05185-04 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC ISOBUTYL NITRITE Date: 03/17/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 18:40:55
CORE ANIMALS
Facility: I. I. T. Research Institute
Chemical CAS #: 542-56-3
Lock Date: 08/20/92
Cage Range: All
Reasons For Removal: 25022 Accidently Killed 25019 Moribund Sacrifice
25020 Natural Death 25021 Terminal Sacrifice
Removal Date Range: All
Treatment Groups: Include All
Note: Animals arranged according to CID number
Page 1
NTP Experiment-Test: 05185-04 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC ISOBUTYL NITRITE Date: 03/17/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 18:40:55
_____________________________________________________________________________________________________________________
| 7| 7| 7| 5| 7| 7| 7| 6| 7| 7| 7| 7| 7| 6| 6| 5| 7| 6| 7| 0| 7| 6| 5| 7| 7|
DAY ON TEST | 3| 0| 2| 7| 3| 2| 3| 8| 2| 2| 2| 3| 3| 9| 9| 8| 3| 1| 2| 7| 3| 9| 8| 2| 2|
| 1| 9| 9| 2| 1| 9| 0| 9| 9| 9| 9| 1| 1| 0| 1| 5| 1| 3| 9| 1| 0| 1| 9| 9| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
CONTROL | 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | + + + M + + + + + + + + + + + A + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + A + + + + + + + + + + + + + + + + + + M + +|
Schwannoma Malignant, Metastatic, | |
Skin | |
__________________________________________________________________________|
Intestine Large, Cecum | + + + A + + + A + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Mixed | X |
__________________________________________________________________________|
Intestine Small, Duodenum | + + + A + + + A + + + + + + + A + + + A + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + A + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + A + + + A + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hepatocellular Carcinoma | X X |
Hepatocellular Carcinoma, Multiple | |
Hepatocellular Adenoma | X X X X|
Hepatocholangiocarcinoma | X |
Histiocytic Sarcoma | |
Lymphoma Malignant Mixed | X X X X |
__________________________________________________________________________|
Mesentery | + + +|
Hepatocellular Carcinoma, Metastatic,| |
Liver | X |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hepatocholangiocarcinoma, Metastatic,| |
Liver | X |
Lymphoma Malignant Mixed | X X X |
Schwannoma Malignant, Metastatic, | |
Skin | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Mixed | X X |
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Mixed | X |
__________________________________________________________________________|
Tooth | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hepatocholangiocarcinoma, Metastatic,| |
Liver | X |
Lymphoma Malignant Mixed | X X |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + M + + + + + + + + + + + + + +|
Lymphoma Malignant Mixed | X X |
Capsule, Lymphoma Malignant Mixed | X |
_____________________________________________________________________________________________________________________|
Page 2
NTP Experiment-Test: 05185-04 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC ISOBUTYL NITRITE Date: 03/17/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 18:40:55
_____________________________________________________________________________________________________________________
| 7| 7| 7| 5| 7| 7| 7| 6| 7| 7| 7| 7| 7| 6| 6| 5| 7| 6| 7| 0| 7| 6| 5| 7| 7|
DAY ON TEST | 3| 0| 2| 7| 3| 2| 3| 8| 2| 2| 2| 3| 3| 9| 9| 8| 3| 1| 2| 7| 3| 9| 8| 2| 2|
| 1| 9| 9| 2| 1| 9| 0| 9| 9| 9| 9| 1| 1| 0| 1| 5| 1| 3| 9| 1| 0| 1| 9| 9| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
CONTROL | 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + M + + + + + + + + + + + + + +|
Lymphoma Malignant Mixed | X X |
__________________________________________________________________________|
Islets, Pancreatic | + |
__________________________________________________________________________|
Parathyroid Gland | M + M + M M + + M + + M + M M M M + M + M + + M M|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + M + + + + + + + + M|
Pars Distalis, Adenoma | X X X X X X X X |
Pars Intermedia, Adenoma | X |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Follicular Cell, Adenoma | X X |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + M + + + +|
Cystadenoma | X |
Lymphoma Malignant Mixed | X X |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemangioma | |
Histiocytic Sarcoma | |
Lymphoma Malignant Mixed | X |
Polyp Stromal | X |
Sarcoma Stromal | X |
__________________________________________________________________________|
Vagina | |
Histiocytic Sarcoma | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Mixed | X |
__________________________________________________________________________|
Lymph Node | + + + |
Inguinal, Histiocytic Sarcoma | |
Lumbar, Histiocytic Sarcoma | |
Lumbar, Lymphoma Malignant Mixed | X X |
Pancreatic, Hepatocholangiocarcinoma,| |
Metastatic, Liver | X |
Renal, Histiocytic Sarcoma | |
Renal, Lymphoma Malignant Mixed | X X |
__________________________________________________________________________|
Lymph Node, Bronchial | M + + M + + M M + + M + + M M M + + + + M M + M M|
Lymphoma Malignant Mixed | X X |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Histiocytic Sarcoma | |
Lymphoma Malignant Mixed | X X X |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Mixed | X X X |
_____________________________________________________________________________________________________________________|
Page 3
NTP Experiment-Test: 05185-04 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC ISOBUTYL NITRITE Date: 03/17/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 18:40:55
_____________________________________________________________________________________________________________________
| 7| 7| 7| 5| 7| 7| 7| 6| 7| 7| 7| 7| 7| 6| 6| 5| 7| 6| 7| 0| 7| 6| 5| 7| 7|
DAY ON TEST | 3| 0| 2| 7| 3| 2| 3| 8| 2| 2| 2| 3| 3| 9| 9| 8| 3| 1| 2| 7| 3| 9| 8| 2| 2|
| 1| 9| 9| 2| 1| 9| 0| 9| 9| 9| 9| 1| 1| 0| 1| 5| 1| 3| 9| 1| 0| 1| 9| 9| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
CONTROL | 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
__________________________________________________________________________|
Lymph Node, Mediastinal | + + + + + + + + + + + + + + + + + + + + + + + + +|
Histiocytic Sarcoma | |
Lymphoma Malignant Mixed | X X |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemangiosarcoma | X |
Histiocytic Sarcoma | |
Lymphoma Malignant Mixed | X X X X |
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + + + M + + + M + + + +|
Lymphoma Malignant Lymphocytic | |
Lymphoma Malignant Mixed | X X X |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + M + + + + + M + + + + + + + + + + +|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Subcutaneous Tissue, Hemangioma | |
Subcutaneous Tissue, Sarcoma | X |
Subcutaneous Tissue, Schwannoma | |
Malignant | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Schwannoma Malignant, Metastatic, | |
Skin | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Alveolar/Bronchiolar Adenoma | X X X |
Alveolar/Bronchiolar Carcinoma | X |
Hepatocellular Carcinoma, Metastatic,| |
Liver | X |
Hepatocholangiocarcinoma, Metastatic,| |
Liver | X |
Lymphoma Malignant Mixed | X X X |
Mediastinum, | |
Hepatocholangiocarcinoma, | |
Metastatic, Liver | X |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
Page 4
NTP Experiment-Test: 05185-04 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC ISOBUTYL NITRITE Date: 03/17/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 18:40:55
_____________________________________________________________________________________________________________________
| 7| 7| 7| 5| 7| 7| 7| 6| 7| 7| 7| 7| 7| 6| 6| 5| 7| 6| 7| 0| 7| 6| 5| 7| 7|
DAY ON TEST | 3| 0| 2| 7| 3| 2| 3| 8| 2| 2| 2| 3| 3| 9| 9| 8| 3| 1| 2| 7| 3| 9| 8| 2| 2|
| 1| 9| 9| 2| 1| 9| 0| 9| 9| 9| 9| 1| 1| 0| 1| 5| 1| 3| 9| 1| 0| 1| 9| 9| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
CONTROL | 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Mixed | X X X |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Histiocytic | |
Lymphoma Malignant Mixed | X X X |
_____________________________________________________________________________________________________________________|
SYSTEMIC LESIONS | |
__________________________________________________________________________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +|
Histiocytic Sarcoma | |
Lymphoma Malignant Histiocytic | |
Lymphoma Malignant Lymphocytic | |
Lymphoma Malignant Mixed | X X X X |
_____________________________________________________________________________________________________________________|
Page 5
NTP Experiment-Test: 05185-04 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC ISOBUTYL NITRITE Date: 03/17/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 18:40:55
_____________________________________________________________________________________________________________________
| 7| 7| 7| 6| 5| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 5| 7| 6| 7| 7| 6| 6| 7|
DAY ON TEST | 3| 3| 2| 3| 7| 0| 2| 3| 3| 3| 2| 3| 3| 3| 3| 2| 3| 9| 3| 4| 2| 3| 9| 4| 3|
| 0| 1| 9| 8| 6| 9| 9| 0| 0| 5| 9| 0| 0| 0| 1| 9| 1| 5| 0| 9| 9| 0| 6| 3| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
CONTROL | 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1|
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | + + + + A + + + + + + + + + + + + + + + + + + M +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + A +|
Schwannoma Malignant, Metastatic, | |
Skin | X |
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + A +|
Lymphoma Malignant Mixed | |
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + A + + + + + + + + + + + A + + + + A A +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + A + + + A + + + + + + + M + + + + A A +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + A + + + + A + + + + + + + A + + + + A A +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hepatocellular Carcinoma | X |
Hepatocellular Carcinoma, Multiple | X |
Hepatocellular Adenoma | X X |
Hepatocholangiocarcinoma | |
Histiocytic Sarcoma | X X |
Lymphoma Malignant Mixed | |
__________________________________________________________________________|
Mesentery | + + + + |
Hepatocellular Carcinoma, Metastatic,| |
Liver | |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hepatocholangiocarcinoma, Metastatic,| |
Liver | |
Lymphoma Malignant Mixed | |
Schwannoma Malignant, Metastatic, | |
Skin | X |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Mixed | |
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Mixed | |
__________________________________________________________________________|
Tooth | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hepatocholangiocarcinoma, Metastatic,| |
Liver | |
Lymphoma Malignant Mixed | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Mixed | |
Capsule, Lymphoma Malignant Mixed | |
_____________________________________________________________________________________________________________________|
Page 6
NTP Experiment-Test: 05185-04 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC ISOBUTYL NITRITE Date: 03/17/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 18:40:55
_____________________________________________________________________________________________________________________
| 7| 7| 7| 6| 5| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 5| 7| 6| 7| 7| 6| 6| 7|
DAY ON TEST | 3| 3| 2| 3| 7| 0| 2| 3| 3| 3| 2| 3| 3| 3| 3| 2| 3| 9| 3| 4| 2| 3| 9| 4| 3|
| 0| 1| 9| 8| 6| 9| 9| 0| 0| 5| 9| 0| 0| 0| 1| 9| 1| 5| 0| 9| 9| 0| 6| 3| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
CONTROL | 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1|
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + M + + + + + + + + + + + + + + +|
Lymphoma Malignant Mixed | |
__________________________________________________________________________|
Islets, Pancreatic | + |
__________________________________________________________________________|
Parathyroid Gland | M M M M M + + + M M + M + + M M M M M + M + M + M|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + M + + + + + + +|
Pars Distalis, Adenoma | X X X X |
Pars Intermedia, Adenoma | X |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Follicular Cell, Adenoma | X X |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + M + + +|
Cystadenoma | |
Lymphoma Malignant Mixed | |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemangioma | X |
Histiocytic Sarcoma | X X |
Lymphoma Malignant Mixed | |
Polyp Stromal | X X |
Sarcoma Stromal | |
__________________________________________________________________________|
Vagina | + |
Histiocytic Sarcoma | X |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Mixed | |
__________________________________________________________________________|
Lymph Node | + |
Inguinal, Histiocytic Sarcoma | X |
Lumbar, Histiocytic Sarcoma | X |
Lumbar, Lymphoma Malignant Mixed | |
Pancreatic, Hepatocholangiocarcinoma,| |
Metastatic, Liver | |
Renal, Histiocytic Sarcoma | X |
Renal, Lymphoma Malignant Mixed | |
__________________________________________________________________________|
Lymph Node, Bronchial | + M + M M M + + + M + M M M M M M M M M M M M M M|
Lymphoma Malignant Mixed | |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + M + + + + + + + + M + + + + + + + + + + + +|
Histiocytic Sarcoma | X |
Lymphoma Malignant Mixed | |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Mixed | X |
_____________________________________________________________________________________________________________________|
Page 7
NTP Experiment-Test: 05185-04 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC ISOBUTYL NITRITE Date: 03/17/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 18:40:55
_____________________________________________________________________________________________________________________
| 7| 7| 7| 6| 5| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 5| 7| 6| 7| 7| 6| 6| 7|
DAY ON TEST | 3| 3| 2| 3| 7| 0| 2| 3| 3| 3| 2| 3| 3| 3| 3| 2| 3| 9| 3| 4| 2| 3| 9| 4| 3|
| 0| 1| 9| 8| 6| 9| 9| 0| 0| 5| 9| 0| 0| 0| 1| 9| 1| 5| 0| 9| 9| 0| 6| 3| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
CONTROL | 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1|
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
__________________________________________________________________________|
Lymph Node, Mediastinal | + + + + + + + + + M M + + + + + + + + + + + + + +|
Histiocytic Sarcoma | X |
Lymphoma Malignant Mixed | |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemangiosarcoma | |
Histiocytic Sarcoma | X |
Lymphoma Malignant Mixed | X |
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + + + + M + + + + + + +|
Lymphoma Malignant Lymphocytic | X |
Lymphoma Malignant Mixed | X |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Subcutaneous Tissue, Hemangioma | X |
Subcutaneous Tissue, Sarcoma | |
Subcutaneous Tissue, Schwannoma | |
Malignant | X |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Schwannoma Malignant, Metastatic, | |
Skin | X |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Alveolar/Bronchiolar Adenoma | X |
Alveolar/Bronchiolar Carcinoma | X |
Hepatocellular Carcinoma, Metastatic,| |
Liver | |
Hepatocholangiocarcinoma, Metastatic,| |
Liver | |
Lymphoma Malignant Mixed | |
Mediastinum, | |
Hepatocholangiocarcinoma, | |
Metastatic, Liver | |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
Page 8
NTP Experiment-Test: 05185-04 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC ISOBUTYL NITRITE Date: 03/17/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 18:40:55
_____________________________________________________________________________________________________________________
| 7| 7| 7| 6| 5| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 5| 7| 6| 7| 7| 6| 6| 7|
DAY ON TEST | 3| 3| 2| 3| 7| 0| 2| 3| 3| 3| 2| 3| 3| 3| 3| 2| 3| 9| 3| 4| 2| 3| 9| 4| 3|
| 0| 1| 9| 8| 6| 9| 9| 0| 0| 5| 9| 0| 0| 0| 1| 9| 1| 5| 0| 9| 9| 0| 6| 3| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
CONTROL | 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1|
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Mixed | |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + M A + +|
Lymphoma Malignant Histiocytic | X |
Lymphoma Malignant Mixed | |
_____________________________________________________________________________________________________________________|
SYSTEMIC LESIONS | |
__________________________________________________________________________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +|
Histiocytic Sarcoma | X X |
Lymphoma Malignant Histiocytic | X |
Lymphoma Malignant Lymphocytic | X |
Lymphoma Malignant Mixed | X |
_____________________________________________________________________________________________________________________|
Page 9
NTP Experiment-Test: 05185-04 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC ISOBUTYL NITRITE Date: 03/17/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 18:40:55
__________________________________________________________________________________________________________________________________
| 0| | |
DAY ON TEST | 9| | |
| 1| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| | O |
B6C3F1 MICE FEMALE | 0| | T |
ANIMAL ID | 1| | A |
CONTROL | 1| | L |
| 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + | 51 |
__________________________________________________________________________|____________|
Gallbladder | A | 46 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + | 51 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + | 48 |
Schwannoma Malignant, Metastatic, | | |
Skin | | 1 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + | 48 |
Lymphoma Malignant Mixed | | 1 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | A | 42 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | A | 44 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + | 44 |
__________________________________________________________________________|____________|
Liver | + | 51 |
Hepatocellular Carcinoma | | 3 |
Hepatocellular Carcinoma, Multiple | | 1 |
Hepatocellular Adenoma | | 6 |
Hepatocholangiocarcinoma | | 1 |
Histiocytic Sarcoma | | 2 |
Lymphoma Malignant Mixed | | 4 |
__________________________________________________________________________|____________|
Mesentery | | 7 |
Hepatocellular Carcinoma, Metastatic,| | |
Liver | | 1 |
__________________________________________________________________________|____________|
Pancreas | + | 51 |
Hepatocholangiocarcinoma, Metastatic,| | |
Liver | | 1 |
Lymphoma Malignant Mixed | | 3 |
Schwannoma Malignant, Metastatic, | | |
Skin | | 1 |
__________________________________________________________________________|____________|
Salivary Glands | + | 51 |
Lymphoma Malignant Mixed | | 2 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + | 51 |
__________________________________________________________________________|____________|
Stomach, Glandular | + | 51 |
Lymphoma Malignant Mixed | | 1 |
__________________________________________________________________________|____________|
Tooth | + | 1 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + | 51 |
Hepatocholangiocarcinoma, Metastatic,| | |
Liver | | 1 |
Lymphoma Malignant Mixed | | 2 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 10
NTP Experiment-Test: 05185-04 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC ISOBUTYL NITRITE Date: 03/17/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 18:40:55
__________________________________________________________________________________________________________________________________
| 0| | |
DAY ON TEST | 9| | |
| 1| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| | O |
B6C3F1 MICE FEMALE | 0| | T |
ANIMAL ID | 1| | A |
CONTROL | 1| | L |
| 5| | |
__________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM - cont | | |
| | |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + | 50 |
Lymphoma Malignant Mixed | | 2 |
Capsule, Lymphoma Malignant Mixed | | 1 |
__________________________________________________________________________|____________|
Adrenal Medulla | + | 47 |
Lymphoma Malignant Mixed | | 2 |
__________________________________________________________________________|____________|
Islets, Pancreatic | | 2 |
__________________________________________________________________________|____________|
Parathyroid Gland | + | 21 |
__________________________________________________________________________|____________|
Pituitary Gland | + | 48 |
Pars Distalis, Adenoma | | 12 |
Pars Intermedia, Adenoma | | 2 |
__________________________________________________________________________|____________|
Thyroid Gland | + | 51 |
Follicular Cell, Adenoma | | 4 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Ovary | + | 49 |
Cystadenoma | | 1 |
Lymphoma Malignant Mixed | | 2 |
__________________________________________________________________________|____________|
Uterus | + | 51 |
Hemangioma | | 1 |
Histiocytic Sarcoma | | 2 |
Lymphoma Malignant Mixed | | 1 |
Polyp Stromal | | 3 |
Sarcoma Stromal | | 1 |
__________________________________________________________________________|____________|
Vagina | | 1 |
Histiocytic Sarcoma | | 1 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + | 51 |
Lymphoma Malignant Mixed | | 1 |
__________________________________________________________________________|____________|
Lymph Node | | 4 |
Inguinal, Histiocytic Sarcoma | | 1 |
Lumbar, Histiocytic Sarcoma | | 1 |
Lumbar, Lymphoma Malignant Mixed | | 2 |
Pancreatic, Hepatocholangiocarcinoma,| | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 11
NTP Experiment-Test: 05185-04 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC ISOBUTYL NITRITE Date: 03/17/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 18:40:55
__________________________________________________________________________________________________________________________________
| 0| | |
DAY ON TEST | 9| | |
| 1| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| | O |
B6C3F1 MICE FEMALE | 0| | T |
ANIMAL ID | 1| | A |
CONTROL | 1| | L |
| 5| | |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
Metastatic, Liver | | 1 |
Renal, Histiocytic Sarcoma | | 1 |
Renal, Lymphoma Malignant Mixed | | 2 |
__________________________________________________________________________|____________|
Lymph Node, Bronchial | + | 20 |
Lymphoma Malignant Mixed | | 2 |
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + | 49 |
Histiocytic Sarcoma | | 1 |
Lymphoma Malignant Mixed | | 3 |
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + | 51 |
Lymphoma Malignant Mixed | | 4 |
__________________________________________________________________________|____________|
Lymph Node, Mediastinal | + | 49 |
Histiocytic Sarcoma | | 1 |
Lymphoma Malignant Mixed | | 2 |
__________________________________________________________________________|____________|
Spleen | + | 51 |
Hemangiosarcoma | | 1 |
Histiocytic Sarcoma | | 1 |
Lymphoma Malignant Mixed | | 5 |
__________________________________________________________________________|____________|
Thymus | M | 47 |
Lymphoma Malignant Lymphocytic | | 1 |
Lymphoma Malignant Mixed | | 4 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + | 49 |
__________________________________________________________________________|____________|
Skin | + | 51 |
Subcutaneous Tissue, Hemangioma | | 1 |
Subcutaneous Tissue, Sarcoma | | 1 |
Subcutaneous Tissue, Schwannoma | | |
Malignant | | 1 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + | 51 |
Schwannoma Malignant, Metastatic, | | |
Skin | | 1 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | M | 50 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Larynx | + | 51 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 12
NTP Experiment-Test: 05185-04 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC ISOBUTYL NITRITE Date: 03/17/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 18:40:55
__________________________________________________________________________________________________________________________________
| 0| | |
DAY ON TEST | 9| | |
| 1| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| | O |
B6C3F1 MICE FEMALE | 0| | T |
ANIMAL ID | 1| | A |
CONTROL | 1| | L |
| 5| | |
__________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Lung | + | 51 |
Alveolar/Bronchiolar Adenoma | | 4 |
Alveolar/Bronchiolar Carcinoma | | 2 |
Hepatocellular Carcinoma, Metastatic,| | |
Liver | | 1 |
Hepatocholangiocarcinoma, Metastatic,| | |
Liver | | 1 |
Lymphoma Malignant Mixed | | 3 |
Mediastinum, | | |
Hepatocholangiocarcinoma, | | |
Metastatic, Liver | | 1 |
__________________________________________________________________________|____________|
Nose | + | 51 |
__________________________________________________________________________|____________|
Trachea | + | 51 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + | 51 |
Lymphoma Malignant Mixed | | 3 |
__________________________________________________________________________|____________|
Urinary Bladder | + | 49 |
Lymphoma Malignant Histiocytic | | 1 |
Lymphoma Malignant Mixed | | 3 |
__________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS | | |
__________________________________________________________________________|____________|
Multiple Organs | + | 51 |
Histiocytic Sarcoma | | 2 |
Lymphoma Malignant Histiocytic | | 1 |
Lymphoma Malignant Lymphocytic | | 1 |
Lymphoma Malignant Mixed | | 5 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 13
NTP Experiment-Test: 05185-04 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC ISOBUTYL NITRITE Date: 03/17/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 18:40:55
_____________________________________________________________________________________________________________________
| 7| 7| 6| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 6| 6| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 3| 2| 9| 3| 3| 3| 3| 2| 2| 3| 2| 2| 3| 0| 2| 3| 3| 1| 4| 2| 3| 2| 3| 3| 3|
| 1| 9| 7| 0| 1| 1| 1| 9| 0| 1| 9| 8| 0| 7| 9| 0| 0| 4| 5| 9| 1| 9| 0| 1| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
37.5 PPM | 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Squamous Cell Carcinoma | X |
__________________________________________________________________________|
Gallbladder | + + + + + + + + M + + + + + + + + + + + + + + M M|
Lymphoma Malignant Undifferentiated | |
Cell Type | X |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + A + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + A + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hepatocellular Carcinoma | X X |
Hepatocellular Adenoma | X X X X|
Histiocytic Sarcoma | |
Lymphoma Malignant Undifferentiated | |
Cell Type | X X |
__________________________________________________________________________|
Mesentery | + + + |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Undifferentiated | |
Cell Type | X |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Mixed | |
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Undifferentiated | |
Cell Type | X |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Undifferentiated | |
Cell Type | X |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Undifferentiated | |
Cell Type | X |
Pheochromocytoma Malignant | |
__________________________________________________________________________|
Islets, Pancreatic | |
Adenoma | |
__________________________________________________________________________|
Parathyroid Gland | + + M M + M M M + M + + + + M + + M M M + M + + +|
__________________________________________________________________________|
Pituitary Gland | + + M + + + + + + + + + + + + + + + + + M + + + +|
Pars Distalis, Adenoma | X X X X X X X|
_____________________________________________________________________________________________________________________|
Page 14
NTP Experiment-Test: 05185-04 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC ISOBUTYL NITRITE Date: 03/17/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 18:40:55
_____________________________________________________________________________________________________________________
| 7| 7| 6| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 6| 6| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 3| 2| 9| 3| 3| 3| 3| 2| 2| 3| 2| 2| 3| 0| 2| 3| 3| 1| 4| 2| 3| 2| 3| 3| 3|
| 1| 9| 7| 0| 1| 1| 1| 9| 0| 1| 9| 8| 0| 7| 9| 0| 0| 4| 5| 9| 1| 9| 0| 1| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
37.5 PPM | 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
Pars Intermedia, Adenoma | X X |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Follicular Cell, Adenoma | X X |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Mixed | |
Lymphoma Malignant Undifferentiated | |
Cell Type | X |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Deciduoma NOS | |
Histiocytic Sarcoma | |
Polyp Stromal | X |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Mixed | |
Lymphoma Malignant Undifferentiated | |
Cell Type | X |
__________________________________________________________________________|
Lymph Node | + + + + |
Lumbar, Lymphoma Malignant | |
Undifferentiated Cell Type | X |
Renal, Lymphoma Malignant | |
Undifferentiated Cell Type | X |
__________________________________________________________________________|
Lymph Node, Bronchial | + + M + + + + + + + + + M M + + M M M M + M + M +|
Lymphoma Malignant Undifferentiated | |
Cell Type | X |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + M + + + + + + + M + + + + + + + + + + + M +|
Lymphoma Malignant Mixed | |
Lymphoma Malignant Undifferentiated | |
Cell Type | X |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Mixed | |
Lymphoma Malignant Undifferentiated | |
Cell Type | X X |
__________________________________________________________________________|
Lymph Node, Mediastinal | M + + M + + + + + + + + + + M M + + + + + + M + +|
Lymphoma Malignant Mixed | |
Lymphoma Malignant Undifferentiated | |
Cell Type | X X |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 15
NTP Experiment-Test: 05185-04 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC ISOBUTYL NITRITE Date: 03/17/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 18:40:55
_____________________________________________________________________________________________________________________
| 7| 7| 6| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 6| 6| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 3| 2| 9| 3| 3| 3| 3| 2| 2| 3| 2| 2| 3| 0| 2| 3| 3| 1| 4| 2| 3| 2| 3| 3| 3|
| 1| 9| 7| 0| 1| 1| 1| 9| 0| 1| 9| 8| 0| 7| 9| 0| 0| 4| 5| 9| 1| 9| 0| 1| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
37.5 PPM | 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Hemangiosarcoma | X |
Lymphoma Malignant Mixed | X |
Lymphoma Malignant Undifferentiated | |
Cell Type | X X |
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Mixed | |
Lymphoma Malignant Undifferentiated | |
Cell Type | X |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Subcutaneous Tissue, Hemangiosarcoma | X |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemangioma | X |
__________________________________________________________________________|
Skeletal Muscle | + |
Hemangiosarcoma | |
Osteosarcoma | X |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Larynx | + + + + + + + + + + + + + + + + + + + + + M + + +|
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Alveolar/Bronchiolar Adenoma | X |
Alveolar/Bronchiolar Adenoma, | |
Multiple | X X |
Alveolar/Bronchiolar Carcinoma | X |
Hepatocellular Carcinoma, Metastatic,| |
Liver | X |
Lymphoma Malignant Mixed | |
Lymphoma Malignant Undifferentiated | |
Cell Type | X X |
Osteosarcoma, Metastatic, Skeletal | |
Muscle | X |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Harderian Gland | + |
Adenoma | X |
_____________________________________________________________________________________________________________________|
Page 16
NTP Experiment-Test: 05185-04 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC ISOBUTYL NITRITE Date: 03/17/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 18:40:55
_____________________________________________________________________________________________________________________
| 7| 7| 6| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 6| 6| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 3| 2| 9| 3| 3| 3| 3| 2| 2| 3| 2| 2| 3| 0| 2| 3| 3| 1| 4| 2| 3| 2| 3| 3| 3|
| 1| 9| 7| 0| 1| 1| 1| 9| 0| 1| 9| 8| 0| 7| 9| 0| 0| 4| 5| 9| 1| 9| 0| 1| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
37.5 PPM | 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM - cont | |
| |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Mixed | |
Lymphoma Malignant Undifferentiated | |
Cell Type | X |
Osteosarcoma, Metastatic, Skeletal | |
Muscle | X |
__________________________________________________________________________|
Urinary Bladder | + + M + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SYSTEMIC LESIONS | |
__________________________________________________________________________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +|
Histiocytic Sarcoma | |
Lymphoma Malignant Mixed | X |
Lymphoma Malignant Undifferentiated | |
Cell Type | X X |
_____________________________________________________________________________________________________________________|
Page 17
NTP Experiment-Test: 05185-04 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC ISOBUTYL NITRITE Date: 03/17/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 18:40:55
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 2| 2| 3| 2| 2| 3| 2| 2| 3| 3| 2| 3| 8| 1| 2| 3| 3| 3| 3| 2| 2| 3| 2| 2| 2|
| 9| 9| 0| 9| 9| 1| 9| 9| 1| 0| 9| 0| 6| 2| 9| 0| 0| 0| 1| 9| 9| 0| 9| 9| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
37.5 PPM | 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3|
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + M + + + + + + + + + + + + + + + +|
Squamous Cell Carcinoma | |
__________________________________________________________________________|
Gallbladder | + + + + + + + + + + + M + + + + + + + + + + + + +|
Lymphoma Malignant Undifferentiated | |
Cell Type | |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + M + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hepatocellular Carcinoma | X X |
Hepatocellular Adenoma | X X X X X X |
Histiocytic Sarcoma | X |
Lymphoma Malignant Undifferentiated | |
Cell Type | |
__________________________________________________________________________|
Mesentery | + |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Undifferentiated | |
Cell Type | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Mixed | X |
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Undifferentiated | |
Cell Type | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Undifferentiated | |
Cell Type | |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Undifferentiated | |
Cell Type | |
Pheochromocytoma Malignant | X |
__________________________________________________________________________|
Islets, Pancreatic | + + |
Adenoma | X |
__________________________________________________________________________|
Parathyroid Gland | M + M + M + + + + + + + M M + M M + + + M M M M +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + I + + + + + + +|
Pars Distalis, Adenoma | X X X X X X X X X X X X |
_____________________________________________________________________________________________________________________|
Page 18
NTP Experiment-Test: 05185-04 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC ISOBUTYL NITRITE Date: 03/17/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 18:40:55
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 2| 2| 3| 2| 2| 3| 2| 2| 3| 3| 2| 3| 8| 1| 2| 3| 3| 3| 3| 2| 2| 3| 2| 2| 2|
| 9| 9| 0| 9| 9| 1| 9| 9| 1| 0| 9| 0| 6| 2| 9| 0| 0| 0| 1| 9| 9| 0| 9| 9| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
37.5 PPM | 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3|
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
Pars Intermedia, Adenoma | |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Follicular Cell, Adenoma | X |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + |
__________________________________________________________________________|
Ovary | + + + + + M + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Mixed | X |
Lymphoma Malignant Undifferentiated | |
Cell Type | |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Deciduoma NOS | X |
Histiocytic Sarcoma | X X |
Polyp Stromal | X |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Mixed | X |
Lymphoma Malignant Undifferentiated | |
Cell Type | |
__________________________________________________________________________|
Lymph Node | + |
Lumbar, Lymphoma Malignant | |
Undifferentiated Cell Type | |
Renal, Lymphoma Malignant | |
Undifferentiated Cell Type | |
__________________________________________________________________________|
Lymph Node, Bronchial | + + + + + + + + + + + M M + M + M + + M + + + M M|
Lymphoma Malignant Undifferentiated | |
Cell Type | |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Mixed | X |
Lymphoma Malignant Undifferentiated | |
Cell Type | |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Mixed | X |
Lymphoma Malignant Undifferentiated | |
Cell Type | |
__________________________________________________________________________|
Lymph Node, Mediastinal | + + + + + + + + + M + + + M + + + + + + + + + + +|
Lymphoma Malignant Mixed | X |
Lymphoma Malignant Undifferentiated | |
Cell Type | |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 19
NTP Experiment-Test: 05185-04 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC ISOBUTYL NITRITE Date: 03/17/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 18:40:55
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 2| 2| 3| 2| 2| 3| 2| 2| 3| 3| 2| 3| 8| 1| 2| 3| 3| 3| 3| 2| 2| 3| 2| 2| 2|
| 9| 9| 0| 9| 9| 1| 9| 9| 1| 0| 9| 0| 6| 2| 9| 0| 0| 0| 1| 9| 9| 0| 9| 9| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
37.5 PPM | 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3|
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Hemangiosarcoma | |
Lymphoma Malignant Mixed | X X |
Lymphoma Malignant Undifferentiated | |
Cell Type | |
__________________________________________________________________________|
Thymus | + + + + + M + + + + + + M M + + + + + + + M + + +|
Lymphoma Malignant Mixed | X |
Lymphoma Malignant Undifferentiated | |
Cell Type | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Subcutaneous Tissue, Hemangiosarcoma | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemangioma | |
__________________________________________________________________________|
Skeletal Muscle | + + |
Hemangiosarcoma | X |
Osteosarcoma | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Larynx | + + + + + + + + + + + + + + + + + M + + + + + + +|
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Alveolar/Bronchiolar Adenoma | X X X X X X X X X X X |
Alveolar/Bronchiolar Adenoma, | |
Multiple | |
Alveolar/Bronchiolar Carcinoma | X |
Hepatocellular Carcinoma, Metastatic,| |
Liver | |
Lymphoma Malignant Mixed | X |
Lymphoma Malignant Undifferentiated | |
Cell Type | |
Osteosarcoma, Metastatic, Skeletal | |
Muscle | |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Harderian Gland | |
Adenoma | |
_____________________________________________________________________________________________________________________|
Page 20
NTP Experiment-Test: 05185-04 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC ISOBUTYL NITRITE Date: 03/17/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 18:40:55
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 2| 2| 3| 2| 2| 3| 2| 2| 3| 3| 2| 3| 8| 1| 2| 3| 3| 3| 3| 2| 2| 3| 2| 2| 2|
| 9| 9| 0| 9| 9| 1| 9| 9| 1| 0| 9| 0| 6| 2| 9| 0| 0| 0| 1| 9| 9| 0| 9| 9| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
37.5 PPM | 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3|
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM - cont | |
| |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Mixed | X |
Lymphoma Malignant Undifferentiated | |
Cell Type | |
Osteosarcoma, Metastatic, Skeletal | |
Muscle | |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SYSTEMIC LESIONS | |
__________________________________________________________________________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +|
Histiocytic Sarcoma | X X |
Lymphoma Malignant Mixed | X X X |
Lymphoma Malignant Undifferentiated | |
Cell Type | |
_____________________________________________________________________________________________________________________|
Page 21
NTP Experiment-Test: 05185-04 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC ISOBUTYL NITRITE Date: 03/17/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 18:40:55
__________________________________________________________________________________________________________________________________
| 1| | |
DAY ON TEST | 8| | |
| 3| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| | O |
B6C3F1 MICE FEMALE | 0| | T |
ANIMAL ID | 2| | A |
37.5 PPM | 4| | L |
| 0| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + | 50 |
Squamous Cell Carcinoma | | 1 |
__________________________________________________________________________|____________|
Gallbladder | + | 47 |
Lymphoma Malignant Undifferentiated | | |
Cell Type | | 1 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + | 51 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + | 51 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | A | 49 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | A | 50 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | M | 50 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | A | 48 |
__________________________________________________________________________|____________|
Liver | + | 51 |
Hepatocellular Carcinoma | | 4 |
Hepatocellular Adenoma | | 10 |
Histiocytic Sarcoma | | 1 |
Lymphoma Malignant Undifferentiated | | |
Cell Type | | 2 |
__________________________________________________________________________|____________|
Mesentery | | 4 |
__________________________________________________________________________|____________|
Pancreas | + | 51 |
Lymphoma Malignant Undifferentiated | | |
Cell Type | | 1 |
__________________________________________________________________________|____________|
Salivary Glands | + | 51 |
Lymphoma Malignant Mixed | | 1 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + | 51 |
__________________________________________________________________________|____________|
Stomach, Glandular | + | 51 |
Lymphoma Malignant Undifferentiated | | |
Cell Type | | 1 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + | 51 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + | 51 |
Lymphoma Malignant Undifferentiated | | |
Cell Type | | 1 |
__________________________________________________________________________|____________|
Adrenal Medulla | + | 49 |
Lymphoma Malignant Undifferentiated | | |
Cell Type | | 1 |
Pheochromocytoma Malignant | | 1 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 22
NTP Experiment-Test: 05185-04 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC ISOBUTYL NITRITE Date: 03/17/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 18:40:55
__________________________________________________________________________________________________________________________________
| 1| | |
DAY ON TEST | 8| | |
| 3| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| | O |
B6C3F1 MICE FEMALE | 0| | T |
ANIMAL ID | 2| | A |
37.5 PPM | 4| | L |
| 0| | |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Islets, Pancreatic | | 2 |
Adenoma | | 1 |
__________________________________________________________________________|____________|
Parathyroid Gland | + | 29 |
__________________________________________________________________________|____________|
Pituitary Gland | + | 48 |
Pars Distalis, Adenoma | | 19 |
Pars Intermedia, Adenoma | | 2 |
__________________________________________________________________________|____________|
Thyroid Gland | + | 51 |
Follicular Cell, Adenoma | | 3 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Clitoral Gland | | 1 |
__________________________________________________________________________|____________|
Ovary | + | 50 |
Lymphoma Malignant Mixed | | 1 |
Lymphoma Malignant Undifferentiated | | |
Cell Type | | 1 |
__________________________________________________________________________|____________|
Uterus | + | 51 |
Deciduoma NOS | | 1 |
Histiocytic Sarcoma | | 2 |
Polyp Stromal | | 2 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + | 51 |
Lymphoma Malignant Mixed | | 1 |
Lymphoma Malignant Undifferentiated | | |
Cell Type | | 1 |
__________________________________________________________________________|____________|
Lymph Node | | 5 |
Lumbar, Lymphoma Malignant | | |
Undifferentiated Cell Type | | 1 |
Renal, Lymphoma Malignant | | |
Undifferentiated Cell Type | | 1 |
__________________________________________________________________________|____________|
Lymph Node, Bronchial | M | 34 |
Lymphoma Malignant Undifferentiated | | |
Cell Type | | 1 |
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + | 48 |
Lymphoma Malignant Mixed | | 1 |
Lymphoma Malignant Undifferentiated | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 23
NTP Experiment-Test: 05185-04 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC ISOBUTYL NITRITE Date: 03/17/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 18:40:55
__________________________________________________________________________________________________________________________________
| 1| | |
DAY ON TEST | 8| | |
| 3| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| | O |
B6C3F1 MICE FEMALE | 0| | T |
ANIMAL ID | 2| | A |
37.5 PPM | 4| | L |
| 0| | |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
Cell Type | | 1 |
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | A | 50 |
Lymphoma Malignant Mixed | | 1 |
Lymphoma Malignant Undifferentiated | | |
Cell Type | | 2 |
__________________________________________________________________________|____________|
Lymph Node, Mediastinal | + | 44 |
Lymphoma Malignant Mixed | | 1 |
Lymphoma Malignant Undifferentiated | | |
Cell Type | | 2 |
__________________________________________________________________________|____________|
Spleen | + | 51 |
Hemangiosarcoma | | 1 |
Lymphoma Malignant Mixed | | 3 |
Lymphoma Malignant Undifferentiated | | |
Cell Type | | 2 |
__________________________________________________________________________|____________|
Thymus | + | 47 |
Lymphoma Malignant Mixed | | 1 |
Lymphoma Malignant Undifferentiated | | |
Cell Type | | 1 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + | 51 |
__________________________________________________________________________|____________|
Skin | + | 51 |
Subcutaneous Tissue, Hemangiosarcoma | | 1 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + | 51 |
Hemangioma | | 1 |
__________________________________________________________________________|____________|
Skeletal Muscle | | 3 |
Hemangiosarcoma | | 1 |
Osteosarcoma | | 1 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + | 51 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Larynx | + | 49 |
__________________________________________________________________________|____________|
Lung | + | 51 |
Alveolar/Bronchiolar Adenoma | | 12 |
Alveolar/Bronchiolar Adenoma, | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 24
NTP Experiment-Test: 05185-04 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC ISOBUTYL NITRITE Date: 03/17/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 18:40:55
__________________________________________________________________________________________________________________________________
| 1| | |
DAY ON TEST | 8| | |
| 3| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| | O |
B6C3F1 MICE FEMALE | 0| | T |
ANIMAL ID | 2| | A |
37.5 PPM | 4| | L |
| 0| | |
__________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont | | |
| | |
Multiple | | 2 |
Alveolar/Bronchiolar Carcinoma | | 2 |
Hepatocellular Carcinoma, Metastatic,| | |
Liver | | 1 |
Lymphoma Malignant Mixed | | 1 |
Lymphoma Malignant Undifferentiated | | |
Cell Type | | 2 |
Osteosarcoma, Metastatic, Skeletal | | |
Muscle | | 1 |
__________________________________________________________________________|____________|
Nose | + | 51 |
__________________________________________________________________________|____________|
Trachea | + | 51 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Harderian Gland | | 1 |
Adenoma | | 1 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + | 51 |
Lymphoma Malignant Mixed | | 1 |
Lymphoma Malignant Undifferentiated | | |
Cell Type | | 1 |
Osteosarcoma, Metastatic, Skeletal | | |
Muscle | | 1 |
__________________________________________________________________________|____________|
Urinary Bladder | + | 50 |
__________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS | | |
__________________________________________________________________________|____________|
Multiple Organs | + | 51 |
Histiocytic Sarcoma | | 2 |
Lymphoma Malignant Mixed | | 4 |
Lymphoma Malignant Undifferentiated | | |
Cell Type | | 2 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 25
NTP Experiment-Test: 05185-04 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC ISOBUTYL NITRITE Date: 03/17/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 18:40:55
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 4| 7| 4| 6| 7| 7| 7| 7| 7| 7| 7| 6| 7| 5| 7| 6| 7| 7| 7| 7|
DAY ON TEST | 2| 2| 3| 3| 2| 3| 3| 6| 2| 1| 3| 3| 3| 2| 3| 2| 6| 3| 5| 3| 6| 2| 0| 3| 3|
| 9| 9| 0| 1| 9| 4| 1| 0| 8| 9| 1| 0| 0| 9| 0| 9| 3| 0| 8| 0| 0| 9| 6| 0| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
75 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | + + + + + + + + + + M + + + + + + + + + + + + + +|
Lymphoma Malignant Undifferentiated | |
Cell Type | X |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Undifferentiated | |
Cell Type | X |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Lymphocytic | X |
Lymphoma Malignant Undifferentiated | |
Cell Type | X |
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + A + + + + + + + + + + + + + + + +|
Lymphoma Malignant Undifferentiated | |
Cell Type | X |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + A + + A + + + + + + + + + + + + + + + +|
Lymphoma Malignant Undifferentiated | |
Cell Type | X |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Lymphocytic | X |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hepatocellular Carcinoma | X X |
Hepatocellular Adenoma | X X |
Hepatocellular Adenoma, Multiple | X X |
Lymphoma Malignant Lymphocytic | X |
Lymphoma Malignant Mixed | X |
Lymphoma Malignant Undifferentiated | |
Cell Type | X |
__________________________________________________________________________|
Mesentery | + |
Lymphoma Malignant Lymphocytic | X |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Lymphocytic | X |
Lymphoma Malignant Mixed | X |
Lymphoma Malignant Undifferentiated | |
Cell Type | X |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Mixed | X |
Lymphoma Malignant Undifferentiated | |
Cell Type | X |
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Lymphocytic | X |
Lymphoma Malignant Undifferentiated | |
Cell Type | X |
_____________________________________________________________________________________________________________________|
Page 26
NTP Experiment-Test: 05185-04 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC ISOBUTYL NITRITE Date: 03/17/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 18:40:55
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 4| 7| 4| 6| 7| 7| 7| 7| 7| 7| 7| 6| 7| 5| 7| 6| 7| 7| 7| 7|
DAY ON TEST | 2| 2| 3| 3| 2| 3| 3| 6| 2| 1| 3| 3| 3| 2| 3| 2| 6| 3| 5| 3| 6| 2| 0| 3| 3|
| 9| 9| 0| 1| 9| 4| 1| 0| 8| 9| 1| 0| 0| 9| 0| 9| 3| 0| 8| 0| 0| 9| 6| 0| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
75 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
__________________________________________________________________________|
Tooth | |
Odontoma | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Lymphocytic | X |
Lymphoma Malignant Undifferentiated | |
Cell Type | X |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Lymphocytic | X |
Lymphoma Malignant Undifferentiated | |
Cell Type | X |
Pheochromocytoma Benign | X |
__________________________________________________________________________|
Islets, Pancreatic | + + + |
__________________________________________________________________________|
Parathyroid Gland | + + M M M + M M M + + + + + + + M + M + + + M + M|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Adenoma | X X X X X X X X|
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Follicular Cell, Adenoma | X|
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + |
__________________________________________________________________________|
Ovary | + + + M + + + + + + + + + + + + + + + M + + + + +|
Cystadenoma | X |
Granulosa Cell Tumor Malignant | |
Lymphoma Malignant Lymphocytic | X |
Lymphoma Malignant Mixed | X |
Lymphoma Malignant Undifferentiated | |
Cell Type | X |
__________________________________________________________________________|
Oviduct | + |
Lymphoma Malignant Lymphocytic | X |
__________________________________________________________________________|
Uterus | + + + M + + + + + + + + + + + + + + + + + + + + +|
Leiomyosarcoma | X |
Lymphoma Malignant Lymphocytic | X |
Lymphoma Malignant Mixed | |
Lymphoma Malignant Undifferentiated | |
Cell Type | X |
__________________________________________________________________________|
Vagina | + |
_____________________________________________________________________________________________________________________|
Page 27
NTP Experiment-Test: 05185-04 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC ISOBUTYL NITRITE Date: 03/17/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 18:40:55
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 4| 7| 4| 6| 7| 7| 7| 7| 7| 7| 7| 6| 7| 5| 7| 6| 7| 7| 7| 7|
DAY ON TEST | 2| 2| 3| 3| 2| 3| 3| 6| 2| 1| 3| 3| 3| 2| 3| 2| 6| 3| 5| 3| 6| 2| 0| 3| 3|
| 9| 9| 0| 1| 9| 4| 1| 0| 8| 9| 1| 0| 0| 9| 0| 9| 3| 0| 8| 0| 0| 9| 6| 0| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
75 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
Lymphoma Malignant Lymphocytic | X |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Mixed | |
Lymphoma Malignant Undifferentiated | |
Cell Type | X |
__________________________________________________________________________|
Lymph Node | + + + + |
Iliac, Lymphoma Malignant Mixed | X |
Inguinal, Lymphoma Malignant | |
Undifferentiated Cell Type | X |
Lumbar, Lymphoma Malignant Mixed | |
Lumbar, Lymphoma Malignant | |
Undifferentiated Cell Type | X |
Renal, Lymphoma Malignant Mixed | X |
Renal, Lymphoma Malignant | |
Undifferentiated Cell Type | X |
__________________________________________________________________________|
Lymph Node, Bronchial | + M + + M + M + + M M + + + + + M + + + M M + M +|
Lymphoma Malignant Lymphocytic | X |
Lymphoma Malignant Mixed | X |
Lymphoma Malignant Undifferentiated | |
Cell Type | X |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Mixed | X X |
Lymphoma Malignant Undifferentiated | |
Cell Type | X |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Lymphocytic | X |
Lymphoma Malignant Mixed | X |
Lymphoma Malignant Undifferentiated | |
Cell Type | X |
__________________________________________________________________________|
Lymph Node, Mediastinal | + + + + M + + + + + + + + + + + M + + + + + + + +|
Lymphoma Malignant Lymphocytic | X |
Lymphoma Malignant Mixed | X X |
Lymphoma Malignant Undifferentiated | |
Cell Type | X |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Lymphocytic | X |
Lymphoma Malignant Mixed | X X |
Lymphoma Malignant Undifferentiated | |
Cell Type | X |
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Lymphocytic | X |
Lymphoma Malignant Mixed | X X |
_____________________________________________________________________________________________________________________|
Page 28
NTP Experiment-Test: 05185-04 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC ISOBUTYL NITRITE Date: 03/17/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 18:40:55
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 4| 7| 4| 6| 7| 7| 7| 7| 7| 7| 7| 6| 7| 5| 7| 6| 7| 7| 7| 7|
DAY ON TEST | 2| 2| 3| 3| 2| 3| 3| 6| 2| 1| 3| 3| 3| 2| 3| 2| 6| 3| 5| 3| 6| 2| 0| 3| 3|
| 9| 9| 0| 1| 9| 4| 1| 0| 8| 9| 1| 0| 0| 9| 0| 9| 3| 0| 8| 0| 0| 9| 6| 0| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
75 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Adenocarcinoma | |
Adenoma | |
Lymphoma Malignant Undifferentiated | |
Cell Type | X |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Subcutaneous Tissue, Fibrosarcoma | X |
Subcutaneous Tissue, Sarcoma | X |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Skeletal Muscle | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Adenoma | |
Alveolar/Bronchiolar Adenoma | X X X|
Alveolar/Bronchiolar Adenoma, | |
Multiple | |
Alveolar/Bronchiolar Carcinoma | X |
Hepatocellular Carcinoma, Metastatic,| |
Liver | X X |
Lymphoma Malignant Lymphocytic | X |
Lymphoma Malignant Mixed | |
Lymphoma Malignant Undifferentiated | |
Cell Type | X |
Mediastinum, Hepatocellular | |
Carcinoma, Metastatic, Liver | X |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Undifferentiated | |
Cell Type | X |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Harderian Gland | |
Adenoma | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
_____________________________________________________________________________________________________________________|
Page 29
NTP Experiment-Test: 05185-04 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC ISOBUTYL NITRITE Date: 03/17/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 18:40:55
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 4| 7| 4| 6| 7| 7| 7| 7| 7| 7| 7| 6| 7| 5| 7| 6| 7| 7| 7| 7|
DAY ON TEST | 2| 2| 3| 3| 2| 3| 3| 6| 2| 1| 3| 3| 3| 2| 3| 2| 6| 3| 5| 3| 6| 2| 0| 3| 3|
| 9| 9| 0| 1| 9| 4| 1| 0| 8| 9| 1| 0| 0| 9| 0| 9| 3| 0| 8| 0| 0| 9| 6| 0| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
75 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM - cont | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Lymphocytic | X |
Lymphoma Malignant Mixed | |
Lymphoma Malignant Undifferentiated | |
Cell Type | X |
__________________________________________________________________________|
Urinary Bladder | + + + M + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Lymphocytic | X |
Lymphoma Malignant Mixed | X X |
Lymphoma Malignant Undifferentiated | |
Cell Type | X |
_____________________________________________________________________________________________________________________|
SYSTEMIC LESIONS | |
__________________________________________________________________________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Lymphocytic | X |
Lymphoma Malignant Mixed | X X X |
Lymphoma Malignant Undifferentiated | |
Cell Type | X |
_____________________________________________________________________________________________________________________|
Page 30
NTP Experiment-Test: 05185-04 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC ISOBUTYL NITRITE Date: 03/17/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 18:40:55
__________________________________________________________________________________________________________________________________
| 7| 6| 7| 7| 7| 4| 7| 7| 6| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 2| |
DAY ON TEST | 3| 3| 3| 2| 3| 1| 3| 3| 3| 8| 3| 3| 3| 2| 2| 2| 2| 3| 2| 2| 2| 3| 2| 5| 1| |
| 0| 6| 0| 9| 1| 5| 0| 0| 9| 5| 0| 1| 0| 9| 9| 9| 9| 0| 9| 9| 9| 0| 9| 8| 0| |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| A |
75 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 0| 5| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Gallbladder | M + + + + A + + + + + + + M + + + + + + + + + + A| 45 |
Lymphoma Malignant Undifferentiated | | |
Cell Type | | 1 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Lymphoma Malignant Undifferentiated | | |
Cell Type | | 1 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Lymphoma Malignant Lymphocytic | | 1 |
Lymphoma Malignant Undifferentiated | | |
Cell Type | | 1 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Lymphoma Malignant Undifferentiated | | |
Cell Type | | 1 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + A + + + + + + + + + + + + + + + + + + +| 47 |
Lymphoma Malignant Undifferentiated | | |
Cell Type | | 1 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Lymphoma Malignant Lymphocytic | | 1 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hepatocellular Carcinoma | | 2 |
Hepatocellular Adenoma | | 2 |
Hepatocellular Adenoma, Multiple | X X X | 5 |
Lymphoma Malignant Lymphocytic | | 1 |
Lymphoma Malignant Mixed | X X X X | 5 |
Lymphoma Malignant Undifferentiated | | |
Cell Type | | 1 |
__________________________________________________________________________|____________|
Mesentery | + + | 3 |
Lymphoma Malignant Lymphocytic | | 1 |
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Lymphoma Malignant Lymphocytic | | 1 |
Lymphoma Malignant Mixed | | 1 |
Lymphoma Malignant Undifferentiated | | |
Cell Type | | 1 |
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Lymphoma Malignant Mixed | X | 2 |
Lymphoma Malignant Undifferentiated | | |
Cell Type | | 1 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 31
NTP Experiment-Test: 05185-04 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC ISOBUTYL NITRITE Date: 03/17/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 18:40:55
__________________________________________________________________________________________________________________________________
| 7| 6| 7| 7| 7| 4| 7| 7| 6| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 2| |
DAY ON TEST | 3| 3| 3| 2| 3| 1| 3| 3| 3| 8| 3| 3| 3| 2| 2| 2| 2| 3| 2| 2| 2| 3| 2| 5| 1| |
| 0| 6| 0| 9| 1| 5| 0| 0| 9| 5| 0| 1| 0| 9| 9| 9| 9| 0| 9| 9| 9| 0| 9| 8| 0| |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| A |
75 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 0| 5| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Lymphoma Malignant Lymphocytic | | 1 |
Lymphoma Malignant Undifferentiated | | |
Cell Type | | 1 |
__________________________________________________________________________|____________|
Tooth | + | 1 |
Odontoma | X | 1 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Lymphoma Malignant Lymphocytic | | 1 |
Lymphoma Malignant Undifferentiated | | |
Cell Type | | 1 |
__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + M + + + + + + + + + + + + + + + + M| 45 |
Lymphoma Malignant Lymphocytic | | 1 |
Lymphoma Malignant Undifferentiated | | |
Cell Type | | 1 |
Pheochromocytoma Benign | X | 2 |
__________________________________________________________________________|____________|
Islets, Pancreatic | | 3 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + M + + + + + M M + + M + M M + M + + + + +| 33 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Pars Distalis, Adenoma | X X X X X X X X X X | 18 |
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Follicular Cell, Adenoma | X | 2 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Clitoral Gland | +| 2 |
__________________________________________________________________________|____________|
Ovary | M + + + + + + + + + + + + + + + + + + M + + + + +| 46 |
Cystadenoma | X | 2 |
Granulosa Cell Tumor Malignant | X| 1 |
Lymphoma Malignant Lymphocytic | | 1 |
Lymphoma Malignant Mixed | X | 2 |
Lymphoma Malignant Undifferentiated | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 32
NTP Experiment-Test: 05185-04 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC ISOBUTYL NITRITE Date: 03/17/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 18:40:55
__________________________________________________________________________________________________________________________________
| 7| 6| 7| 7| 7| 4| 7| 7| 6| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 2| |
DAY ON TEST | 3| 3| 3| 2| 3| 1| 3| 3| 3| 8| 3| 3| 3| 2| 2| 2| 2| 3| 2| 2| 2| 3| 2| 5| 1| |
| 0| 6| 0| 9| 1| 5| 0| 0| 9| 5| 0| 1| 0| 9| 9| 9| 9| 0| 9| 9| 9| 0| 9| 8| 0| |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| A |
75 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 0| 5| |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont | | |
| | |
Cell Type | | 1 |
__________________________________________________________________________|____________|
Oviduct | | 1 |
Lymphoma Malignant Lymphocytic | | 1 |
__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Leiomyosarcoma | | 1 |
Lymphoma Malignant Lymphocytic | | 1 |
Lymphoma Malignant Mixed | X | 1 |
Lymphoma Malignant Undifferentiated | | |
Cell Type | | 1 |
__________________________________________________________________________|____________|
Vagina | | 1 |
Lymphoma Malignant Lymphocytic | | 1 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Lymphoma Malignant Mixed | X X X | 3 |
Lymphoma Malignant Undifferentiated | | |
Cell Type | | 1 |
__________________________________________________________________________|____________|
Lymph Node | + + + +| 8 |
Iliac, Lymphoma Malignant Mixed | | 1 |
Inguinal, Lymphoma Malignant | | |
Undifferentiated Cell Type | | 1 |
Lumbar, Lymphoma Malignant Mixed | X X | 2 |
Lumbar, Lymphoma Malignant | | |
Undifferentiated Cell Type | | 1 |
Renal, Lymphoma Malignant Mixed | X | 2 |
Renal, Lymphoma Malignant | | |
Undifferentiated Cell Type | | 1 |
__________________________________________________________________________|____________|
Lymph Node, Bronchial | + + + + + + + + M M M + + + M M + + M + M + M + M| 32 |
Lymphoma Malignant Lymphocytic | | 1 |
Lymphoma Malignant Mixed | X | 2 |
Lymphoma Malignant Undifferentiated | | |
Cell Type | | 1 |
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + M + + M + +| 48 |
Lymphoma Malignant Mixed | X X | 4 |
Lymphoma Malignant Undifferentiated | | |
Cell Type | | 1 |
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + M + + + + + + + + +| 49 |
Lymphoma Malignant Lymphocytic | | 1 |
Lymphoma Malignant Mixed | X X | 3 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 33
NTP Experiment-Test: 05185-04 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC ISOBUTYL NITRITE Date: 03/17/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 18:40:55
__________________________________________________________________________________________________________________________________
| 7| 6| 7| 7| 7| 4| 7| 7| 6| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 2| |
DAY ON TEST | 3| 3| 3| 2| 3| 1| 3| 3| 3| 8| 3| 3| 3| 2| 2| 2| 2| 3| 2| 2| 2| 3| 2| 5| 1| |
| 0| 6| 0| 9| 1| 5| 0| 0| 9| 5| 0| 1| 0| 9| 9| 9| 9| 0| 9| 9| 9| 0| 9| 8| 0| |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| A |
75 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 0| 5| |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
Lymphoma Malignant Undifferentiated | | |
Cell Type | | 1 |
__________________________________________________________________________|____________|
Lymph Node, Mediastinal | + + + + + + + + + + + M + + + + + M + + + + + + +| 46 |
Lymphoma Malignant Lymphocytic | | 1 |
Lymphoma Malignant Mixed | X X | 4 |
Lymphoma Malignant Undifferentiated | | |
Cell Type | | 1 |
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Lymphoma Malignant Lymphocytic | | 1 |
Lymphoma Malignant Mixed | X X X X X | 7 |
Lymphoma Malignant Undifferentiated | | |
Cell Type | | 1 |
__________________________________________________________________________|____________|
Thymus | + + + + + + M + + + + M + + + + + + + + + + + + +| 48 |
Lymphoma Malignant Lymphocytic | | 1 |
Lymphoma Malignant Mixed | X X X | 5 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Adenocarcinoma | X | 1 |
Adenoma | X | 1 |
Lymphoma Malignant Undifferentiated | | |
Cell Type | | 1 |
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Subcutaneous Tissue, Fibrosarcoma | | 1 |
Subcutaneous Tissue, Sarcoma | | 1 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Skeletal Muscle | + | 1 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Adenoma | X | 1 |
Alveolar/Bronchiolar Adenoma | X X | 5 |
Alveolar/Bronchiolar Adenoma, | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 34
NTP Experiment-Test: 05185-04 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC ISOBUTYL NITRITE Date: 03/17/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 18:40:55
__________________________________________________________________________________________________________________________________
| 7| 6| 7| 7| 7| 4| 7| 7| 6| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 2| |
DAY ON TEST | 3| 3| 3| 2| 3| 1| 3| 3| 3| 8| 3| 3| 3| 2| 2| 2| 2| 3| 2| 2| 2| 3| 2| 5| 1| |
| 0| 6| 0| 9| 1| 5| 0| 0| 9| 5| 0| 1| 0| 9| 9| 9| 9| 0| 9| 9| 9| 0| 9| 8| 0| |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| A |
75 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 0| 5| |
__________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont | | |
| | |
Multiple | X | 1 |
Alveolar/Bronchiolar Carcinoma | X | 2 |
Hepatocellular Carcinoma, Metastatic,| | |
Liver | | 2 |
Lymphoma Malignant Lymphocytic | | 1 |
Lymphoma Malignant Mixed | X X | 2 |
Lymphoma Malignant Undifferentiated | | |
Cell Type | | 1 |
Mediastinum, Hepatocellular | | |
Carcinoma, Metastatic, Liver | | 1 |
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Lymphoma Malignant Undifferentiated | | |
Cell Type | | 1 |
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Harderian Gland | + + | 2 |
Adenoma | X | 1 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Lymphoma Malignant Lymphocytic | | 1 |
Lymphoma Malignant Mixed | X X X | 3 |
Lymphoma Malignant Undifferentiated | | |
Cell Type | | 1 |
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + M + + + + + + + + + + + + + + + + +| 48 |
Lymphoma Malignant Lymphocytic | | 1 |
Lymphoma Malignant Mixed | X | 3 |
Lymphoma Malignant Undifferentiated | | |
Cell Type | | 1 |
__________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS | | |
__________________________________________________________________________|____________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Lymphoma Malignant Lymphocytic | | 1 |
Lymphoma Malignant Mixed | X X X X X X | 9 |
Lymphoma Malignant Undifferentiated | | |
Cell Type | | 1 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 35
NTP Experiment-Test: 05185-04 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC ISOBUTYL NITRITE Date: 03/17/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 18:40:55
_____________________________________________________________________________________________________________________
| 7| 5| 7| 7| 7| 4| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 4| 7| 7| 7| 6|
DAY ON TEST | 2| 8| 2| 2| 3| 9| 2| 2| 3| 2| 3| 2| 2| 2| 2| 3| 2| 3| 2| 0| 8| 2| 3| 3| 9|
| 9| 3| 9| 9| 0| 4| 9| 5| 0| 9| 0| 9| 9| 9| 4| 0| 9| 0| 9| 3| 5| 9| 1| 1| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
150 PPM | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | M + + + + + + + + + + + + + + + + + + + + + + + M|
__________________________________________________________________________|
Gallbladder | + + + + + + + A + + + + + + + + + + + A A M + + +|
Lymphoma Malignant Lymphocytic | X|
__________________________________________________________________________|
Intestine Large, Colon | + A + + + + + + + + + + + + + + + + + A A + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + A A + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + A A + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + A + + + + + A + + + + + + + + + + + A A + + + A|
__________________________________________________________________________|
Intestine Small, Jejunum | + A + + + + + + + + + + + + + + + + + A + + + + +|
Lymphoma Malignant Mixed | |
__________________________________________________________________________|
Intestine Small, Ileum | + A + + + + + + + + + + + + + + + + + A A + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hepatocellular Carcinoma | X X |
Hepatocellular Adenoma | X X |
Hepatocellular Adenoma, Multiple | X |
Histiocytic Sarcoma | X |
Lymphoma Malignant Lymphocytic | X|
Lymphoma Malignant Mixed | X |
__________________________________________________________________________|
Mesentery | + + |
Lymphoma Malignant Mixed | X |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Lymphocytic | X|
Lymphoma Malignant Mixed | X |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Lymphocytic | X|
Lymphoma Malignant Mixed | X |
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + A + + + +|
Lymphoma Malignant Lymphocytic | X|
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + A + + + +|
__________________________________________________________________________|
Tooth | |
Odontoma | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Lymphocytic | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Subcapsular, Lymphoma Malignant Mixed| |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + +|
Pheochromocytoma Benign | X X |
__________________________________________________________________________|
Islets, Pancreatic | + + + |
__________________________________________________________________________|
Parathyroid Gland | + M + + + + + + M + + M + + + + + + + + M M M + M|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + M + + + + + + + + + M + + + M + + +|
Pars Distalis, Adenoma | X X X X X X X X X|
_____________________________________________________________________________________________________________________|
Page 36
NTP Experiment-Test: 05185-04 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC ISOBUTYL NITRITE Date: 03/17/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 18:40:55
_____________________________________________________________________________________________________________________
| 7| 5| 7| 7| 7| 4| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 4| 7| 7| 7| 6|
DAY ON TEST | 2| 8| 2| 2| 3| 9| 2| 2| 3| 2| 3| 2| 2| 2| 2| 3| 2| 3| 2| 0| 8| 2| 3| 3| 9|
| 9| 3| 9| 9| 0| 4| 9| 5| 0| 9| 0| 9| 9| 9| 4| 0| 9| 0| 9| 3| 5| 9| 1| 1| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
150 PPM | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Follicular Cell, Adenoma | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + |
__________________________________________________________________________|
Ovary | + + + + + M + + + + + + + + + + + + + + + + + + +|
Cystadenoma | X |
Granulosa Cell Tumor Benign | X |
Lymphoma Malignant Lymphocytic | X|
Lymphoma Malignant Mixed | |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Histiocytic Sarcoma | |
Leiomyosarcoma | |
Myxoma | X |
Polyp Stromal | |
__________________________________________________________________________|
Vagina | + + |
Squamous Cell Carcinoma | X |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Lymphocytic | X|
Lymphoma Malignant Mixed | X |
__________________________________________________________________________|
Lymph Node | + + +|
Inguinal, Lymphoma Malignant | |
Lymphocytic | X|
Inguinal, Lymphoma Malignant Mixed | |
Lumbar, Lymphoma Malignant | |
Lymphocytic | X|
Lumbar, Lymphoma Malignant Mixed | |
Pancreatic, Lymphoma Malignant Mixed | |
Renal, Lymphoma Malignant Lymphocytic| X|
Renal, Lymphoma Malignant Mixed | |
__________________________________________________________________________|
Lymph Node, Bronchial | M + + + + + + M + + M + + M M M + M M + + M + + +|
Lymphoma Malignant Lymphocytic | X|
Lymphoma Malignant Mixed | X |
__________________________________________________________________________|
Lymph Node, Mandibular | M + + + + + + + + + + + M + + M + + + + + + + + +|
Lymphoma Malignant Lymphocytic | X X|
Lymphoma Malignant Mixed | X |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + M + + + + + + + + + + + A + + + + +|
Hemangioma | |
Histiocytic Sarcoma | X |
_____________________________________________________________________________________________________________________|
Page 37
NTP Experiment-Test: 05185-04 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC ISOBUTYL NITRITE Date: 03/17/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 18:40:55
_____________________________________________________________________________________________________________________
| 7| 5| 7| 7| 7| 4| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 4| 7| 7| 7| 6|
DAY ON TEST | 2| 8| 2| 2| 3| 9| 2| 2| 3| 2| 3| 2| 2| 2| 2| 3| 2| 3| 2| 0| 8| 2| 3| 3| 9|
| 9| 3| 9| 9| 0| 4| 9| 5| 0| 9| 0| 9| 9| 9| 4| 0| 9| 0| 9| 3| 5| 9| 1| 1| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
150 PPM | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Lymphoma Malignant Mixed | |
__________________________________________________________________________|
Lymph Node, Mediastinal | + + + + + M + + + + + M + + + + + + + + + + + + +|
Lymphoma Malignant Lymphocytic | X|
Lymphoma Malignant Mixed | X |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + A + + + +|
Lymphoma Malignant Lymphocytic | X X|
Lymphoma Malignant Mixed | X X |
__________________________________________________________________________|
Thymus | + + + + + M + M + + + + + M + + + + + + A M + + M|
Lymphoma Malignant Lymphocytic | |
Lymphoma Malignant Mixed | X X X |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Lymphocytic | X|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Skeletal Muscle | |
Sarcoma | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Peripheral Nerve | + |
__________________________________________________________________________|
Spinal Cord | + |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Larynx | + + + + M + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Alveolar/Bronchiolar Adenoma | X X X X X X X X |
Alveolar/Bronchiolar Adenoma, | |
Multiple | X X |
Alveolar/Bronchiolar Carcinoma | X |
Hepatocellular Carcinoma, Metastatic,| |
Liver | X |
Histiocytic Sarcoma | X |
Lymphoma Malignant Lymphocytic | X|
Lymphoma Malignant Mixed | X |
Mediastinum, Lymphoma Malignant | |
Lymphocytic | |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
_____________________________________________________________________________________________________________________|
Page 38
NTP Experiment-Test: 05185-04 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC ISOBUTYL NITRITE Date: 03/17/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 18:40:55
_____________________________________________________________________________________________________________________
| 7| 5| 7| 7| 7| 4| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 4| 7| 7| 7| 6|
DAY ON TEST | 2| 8| 2| 2| 3| 9| 2| 2| 3| 2| 3| 2| 2| 2| 2| 3| 2| 3| 2| 0| 8| 2| 3| 3| 9|
| 9| 3| 9| 9| 0| 4| 9| 5| 0| 9| 0| 9| 9| 9| 4| 0| 9| 0| 9| 3| 5| 9| 1| 1| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
150 PPM | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM - cont | |
| |
__________________________________________________________________________|
Ear | + |
__________________________________________________________________________|
Eye | + |
__________________________________________________________________________|
Harderian Gland | + + |
Adenoma | X X |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Histiocytic Sarcoma | X |
Lymphoma Malignant Lymphocytic | X|
Lymphoma Malignant Mixed | X X |
__________________________________________________________________________|
Urinary Bladder | + A + + + + + + + + + + + + + + + + + A A + + + +|
Lymphoma Malignant Lymphocytic | X|
_____________________________________________________________________________________________________________________|
SYSTEMIC LESIONS | |
__________________________________________________________________________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +|
Histiocytic Sarcoma | X |
Lymphoma Malignant Lymphocytic | X X|
Lymphoma Malignant Mixed | X X X |
_____________________________________________________________________________________________________________________|
Page 39
NTP Experiment-Test: 05185-04 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC ISOBUTYL NITRITE Date: 03/17/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 18:40:55
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 0| 7| 7| 0| 7| 7| 7| 7| 7| 1| 7| 6| 7| 7| |
DAY ON TEST | 2| 3| 3| 3| 2| 3| 3| 2| 3| 3| 2| 6| 3| 2| 7| 3| 1| 2| 2| 2| 1| 2| 4| 2| 3| |
| 1| 1| 0| 0| 9| 0| 0| 9| 0| 1| 9| 5| 1| 9| 1| 1| 6| 9| 9| 9| 4| 9| 6| 9| 0| |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| A |
150 PPM | 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | M + + + + + + + + + + + + + + + + + + + + + + + +| 47 |
__________________________________________________________________________|____________|
Gallbladder | A + + + + + + + + + + A + + + M A + + + + + A + +| 41 |
Lymphoma Malignant Lymphocytic | | 1 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + A + + + + + + + + + + + + +| 46 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + + + A + + + + + + + + + +| 47 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + + A + + A + + + + + + + A + +| 45 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + A + + A + + + + + + + A + +| 42 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + + A + + A + + + + + + + A + +| 45 |
Lymphoma Malignant Mixed | X| 1 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + + A + + A + + + + + + + A + +| 44 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hepatocellular Carcinoma | X X X | 5 |
Hepatocellular Adenoma | X X | 4 |
Hepatocellular Adenoma, Multiple | X | 2 |
Histiocytic Sarcoma | | 1 |
Lymphoma Malignant Lymphocytic | | 1 |
Lymphoma Malignant Mixed | X X| 3 |
__________________________________________________________________________|____________|
Mesentery | | 2 |
Lymphoma Malignant Mixed | | 1 |
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Lymphoma Malignant Lymphocytic | | 1 |
Lymphoma Malignant Mixed | X| 2 |
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Lymphoma Malignant Lymphocytic | | 1 |
Lymphoma Malignant Mixed | | 1 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Lymphoma Malignant Lymphocytic | | 1 |
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Tooth | + | 1 |
Odontoma | X | 1 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Lymphoma Malignant Lymphocytic | X | 1 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + M + + + + + + + + + + + + + + + + +| 49 |
Subcapsular, Lymphoma Malignant Mixed| X| 1 |
__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + M + + + + + + + + + + + + + + + +| 47 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 40
NTP Experiment-Test: 05185-04 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC ISOBUTYL NITRITE Date: 03/17/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 18:40:55
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 0| 7| 7| 0| 7| 7| 7| 7| 7| 1| 7| 6| 7| 7| |
DAY ON TEST | 2| 3| 3| 3| 2| 3| 3| 2| 3| 3| 2| 6| 3| 2| 7| 3| 1| 2| 2| 2| 1| 2| 4| 2| 3| |
| 1| 1| 0| 0| 9| 0| 0| 9| 0| 1| 9| 5| 1| 9| 1| 1| 6| 9| 9| 9| 4| 9| 6| 9| 0| |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| A |
150 PPM | 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
Pheochromocytoma Benign | | 2 |
__________________________________________________________________________|____________|
Islets, Pancreatic | | 3 |
__________________________________________________________________________|____________|
Parathyroid Gland | M M M + M M M + + M M M + + + + + + M M + + M + +| 31 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 47 |
Pars Distalis, Adenoma | X X X X | 13 |
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Follicular Cell, Adenoma | X X | 2 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Clitoral Gland | + | 3 |
__________________________________________________________________________|____________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Cystadenoma | | 1 |
Granulosa Cell Tumor Benign | | 1 |
Lymphoma Malignant Lymphocytic | | 1 |
Lymphoma Malignant Mixed | X| 1 |
__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + + M + + + + + + + + + + + + +| 49 |
Histiocytic Sarcoma | X | 1 |
Leiomyosarcoma | X | 1 |
Myxoma | | 1 |
Polyp Stromal | X | 1 |
__________________________________________________________________________|____________|
Vagina | | 2 |
Squamous Cell Carcinoma | | 1 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Lymphoma Malignant Lymphocytic | | 1 |
Lymphoma Malignant Mixed | | 1 |
__________________________________________________________________________|____________|
Lymph Node | + + +| 6 |
Inguinal, Lymphoma Malignant | | |
Lymphocytic | | 1 |
Inguinal, Lymphoma Malignant Mixed | X| 1 |
Lumbar, Lymphoma Malignant | | |
Lymphocytic | | 1 |
Lumbar, Lymphoma Malignant Mixed | X | 1 |
Pancreatic, Lymphoma Malignant Mixed | X | 1 |
Renal, Lymphoma Malignant Lymphocytic| | 1 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 41
NTP Experiment-Test: 05185-04 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC ISOBUTYL NITRITE Date: 03/17/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 18:40:55
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 0| 7| 7| 0| 7| 7| 7| 7| 7| 1| 7| 6| 7| 7| |
DAY ON TEST | 2| 3| 3| 3| 2| 3| 3| 2| 3| 3| 2| 6| 3| 2| 7| 3| 1| 2| 2| 2| 1| 2| 4| 2| 3| |
| 1| 1| 0| 0| 9| 0| 0| 9| 0| 1| 9| 5| 1| 9| 1| 1| 6| 9| 9| 9| 4| 9| 6| 9| 0| |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| A |
150 PPM | 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
Renal, Lymphoma Malignant Mixed | X| 1 |
__________________________________________________________________________|____________|
Lymph Node, Bronchial | M + + + M + + M + M + + + M + M + M + + + M M M M| 30 |
Lymphoma Malignant Lymphocytic | X | 2 |
Lymphoma Malignant Mixed | X | 2 |
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + + M + + + + + + + + + + + + M| 45 |
Lymphoma Malignant Lymphocytic | | 2 |
Lymphoma Malignant Mixed | X | 2 |
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + + A + + A + + + + + + + A + +| 45 |
Hemangioma | X | 1 |
Histiocytic Sarcoma | | 1 |
Lymphoma Malignant Mixed | X| 1 |
__________________________________________________________________________|____________|
Lymph Node, Mediastinal | M + + + + + + + + + + M M + + + + M + M + + + + +| 43 |
Lymphoma Malignant Lymphocytic | X | 2 |
Lymphoma Malignant Mixed | X X| 3 |
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Lymphoma Malignant Lymphocytic | | 2 |
Lymphoma Malignant Mixed | X X X| 5 |
__________________________________________________________________________|____________|
Thymus | M M + + + + + M + + + + + + + + + + + + + + + + +| 41 |
Lymphoma Malignant Lymphocytic | X | 1 |
Lymphoma Malignant Mixed | X X X| 6 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Lymphoma Malignant Lymphocytic | | 1 |
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Skeletal Muscle | + | 1 |
Sarcoma | X | 1 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Peripheral Nerve | | 1 |
__________________________________________________________________________|____________|
Spinal Cord | | 1 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 42
NTP Experiment-Test: 05185-04 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC ISOBUTYL NITRITE Date: 03/17/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 18:40:55
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 0| 7| 7| 0| 7| 7| 7| 7| 7| 1| 7| 6| 7| 7| |
DAY ON TEST | 2| 3| 3| 3| 2| 3| 3| 2| 3| 3| 2| 6| 3| 2| 7| 3| 1| 2| 2| 2| 1| 2| 4| 2| 3| |
| 1| 1| 0| 0| 9| 0| 0| 9| 0| 1| 9| 5| 1| 9| 1| 1| 6| 9| 9| 9| 4| 9| 6| 9| 0| |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| A |
150 PPM | 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont | | |
| | |
Alveolar/Bronchiolar Adenoma | X X X X X X X | 15 |
Alveolar/Bronchiolar Adenoma, | | |
Multiple | | 2 |
Alveolar/Bronchiolar Carcinoma | X | 2 |
Hepatocellular Carcinoma, Metastatic,| | |
Liver | X X | 3 |
Histiocytic Sarcoma | | 1 |
Lymphoma Malignant Lymphocytic | | 1 |
Lymphoma Malignant Mixed | | 1 |
Mediastinum, Lymphoma Malignant | | |
Lymphocytic | X | 1 |
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Ear | | 1 |
__________________________________________________________________________|____________|
Eye | | 1 |
__________________________________________________________________________|____________|
Harderian Gland | | 2 |
Adenoma | | 2 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Histiocytic Sarcoma | | 1 |
Lymphoma Malignant Lymphocytic | | 1 |
Lymphoma Malignant Mixed | | 2 |
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 47 |
Lymphoma Malignant Lymphocytic | | 1 |
__________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS | | |
__________________________________________________________________________|____________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Histiocytic Sarcoma | X | 2 |
Lymphoma Malignant Lymphocytic | X | 3 |
Lymphoma Malignant Mixed | X X X| 6 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 43
NTP Experiment-Test: 05185-04 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC ISOBUTYL NITRITE Date: 03/17/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 18:40:55
_____________________________________________________________________________________________________________________
| 7| 5| 7| 7| 7| 7| 4| 7| 5| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 2| 1| 2| 2| 2| 2| 5| 2| 2| 2| 2| 2| 2| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
| 6| 2| 6| 5| 5| 5| 5| 6| 9| 6| 5| 6| 5| 8| 6| 5| 5| 6| 6| 6| 6| 5| 6| 6| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
CONTROL | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | + + + + + + A + A + + + + + + + + M + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + A + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + A + + + + + + A + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + A + A + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + A + M + + + + A + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + A + + + + A + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemangiosarcoma | X |
Hemangiosarcoma, Multiple | |
Hepatocellular Carcinoma | X X X X X X |
Hepatocellular Carcinoma, Multiple | X |
Hepatocellular Adenoma | X X X X X |
Hepatocellular Adenoma, Multiple | X X|
Lymphoma Malignant Mixed | X |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Mixed | X |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Tooth | + |
Odontoma | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + I + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Mixed | X |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + I + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Mixed | X |
__________________________________________________________________________|
Islets, Pancreatic | + + +|
Adenoma | X|
__________________________________________________________________________|
Parathyroid Gland | M + + + + + + + + + M M M M M M M M + M + + + M M|
__________________________________________________________________________|
Pituitary Gland | + + + + + M + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Follicular Cell, Adenoma | X |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 44
NTP Experiment-Test: 05185-04 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC ISOBUTYL NITRITE Date: 03/17/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 18:40:55
_____________________________________________________________________________________________________________________
| 7| 5| 7| 7| 7| 7| 4| 7| 5| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 2| 1| 2| 2| 2| 2| 5| 2| 2| 2| 2| 2| 2| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
| 6| 2| 6| 5| 5| 5| 5| 6| 9| 6| 5| 6| 5| 8| 6| 5| 5| 6| 6| 6| 6| 5| 6| 6| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
CONTROL | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
Lymphoma Malignant Mixed | X |
__________________________________________________________________________|
Penis | + |
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Mixed | X |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Mixed | X |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Mixed | X |
__________________________________________________________________________|
Lymph Node | + |
Lumbar, Lymphoma Malignant Mixed | X |
Renal, Lymphoma Malignant Mixed | X |
__________________________________________________________________________|
Lymph Node, Bronchial | + + M M + M + + + + M + M M M M + M + M M + + +|
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + M + + M + M + + + + + + + + + + + + + M|
Lymphoma Malignant Mixed | X |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Mixed | X |
__________________________________________________________________________|
Lymph Node, Mediastinal | + M M M + + + + M + + + + + M + + + + + + M + + +|
Lymphoma Malignant Mixed | X |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemangioma | |
Lymphoma Malignant Mixed | X |
__________________________________________________________________________|
Thymus | + + + + M M + + + + + M + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | M M M M M M M M M M M M M M M M M M M M M M + M M|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Subcutaneous Tissue, Lymphoma | |
Malignant Mixed | X |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Mixed | X |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Alveolar/Bronchiolar Adenoma | X X X X |
_____________________________________________________________________________________________________________________|
Page 45
NTP Experiment-Test: 05185-04 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC ISOBUTYL NITRITE Date: 03/17/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 18:40:55
_____________________________________________________________________________________________________________________
| 7| 5| 7| 7| 7| 7| 4| 7| 5| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 2| 1| 2| 2| 2| 2| 5| 2| 2| 2| 2| 2| 2| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
| 6| 2| 6| 5| 5| 5| 5| 6| 9| 6| 5| 6| 5| 8| 6| 5| 5| 6| 6| 6| 6| 5| 6| 6| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
CONTROL | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
Alveolar/Bronchiolar Carcinoma | |
Hepatocellular Carcinoma, Metastatic,| |
Liver | X X X |
Lymphoma Malignant Mixed | X |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Harderian Gland | + + + +|
Adenoma | X X X|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Mixed | X |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SYSTEMIC LESIONS | |
__________________________________________________________________________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Mixed | X |
_____________________________________________________________________________________________________________________|
Page 46
NTP Experiment-Test: 05185-04 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC ISOBUTYL NITRITE Date: 03/17/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 18:40:55
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 0| 7| 7| 7| 7| 7| 7| 7| 7| 5| 1| 6| 7| 7| 7| 7| 5| 5| 5| 7| 4| 7| |
DAY ON TEST | 2| 2| 2| 6| 2| 2| 2| 2| 2| 2| 2| 2| 0| 3| 0| 2| 2| 1| 2| 6| 7| 9| 2| 7| 2| |
| 6| 6| 6| 1| 6| 6| 6| 6| 6| 6| 6| 5| 9| 6| 4| 5| 6| 1| 5| 3| 0| 4| 6| 9| 5| |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| A |
CONTROL | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Gallbladder | + + + + + + + + + + + + M + A + + A + A A A + + +| 41 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + A + + + +| 49 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + + + A + + + + A + A A + + + +| 44 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + A + + A + + A A + A +| 43 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + A + A A A + A +| 42 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + A + A A + + + +| 45 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hemangiosarcoma | | 1 |
Hemangiosarcoma, Multiple | X | 1 |
Hepatocellular Carcinoma | X X X | 9 |
Hepatocellular Carcinoma, Multiple | X X | 3 |
Hepatocellular Adenoma | X X X X X| 10 |
Hepatocellular Adenoma, Multiple | X X | 4 |
Lymphoma Malignant Mixed | | 1 |
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Lymphoma Malignant Mixed | | 1 |
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + A + + + + + + +| 49 |
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + A + + + + + + +| 49 |
__________________________________________________________________________|____________|
Tooth | + + | 3 |
Odontoma | X | 1 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Lymphoma Malignant Mixed | | 1 |
__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Lymphoma Malignant Mixed | | 1 |
__________________________________________________________________________|____________|
Islets, Pancreatic | + + | 5 |
Adenoma | X | 2 |
__________________________________________________________________________|____________|
Parathyroid Gland | M + + + M + M + + M M + + + M + + + M + + + M + M| 29 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + M + + + M +| 47 |
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Follicular Cell, Adenoma | | 1 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 47
NTP Experiment-Test: 05185-04 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC ISOBUTYL NITRITE Date: 03/17/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 18:40:55
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 0| 7| 7| 7| 7| 7| 7| 7| 7| 5| 1| 6| 7| 7| 7| 7| 5| 5| 5| 7| 4| 7| |
DAY ON TEST | 2| 2| 2| 6| 2| 2| 2| 2| 2| 2| 2| 2| 0| 3| 0| 2| 2| 1| 2| 6| 7| 9| 2| 7| 2| |
| 6| 6| 6| 1| 6| 6| 6| 6| 6| 6| 6| 5| 9| 6| 4| 5| 6| 1| 5| 3| 0| 4| 6| 9| 5| |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| A |
CONTROL | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Lymphoma Malignant Mixed | | 1 |
__________________________________________________________________________|____________|
Penis | | 1 |
__________________________________________________________________________|____________|
Preputial Gland | + + + + +| 16 |
__________________________________________________________________________|____________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Lymphoma Malignant Mixed | | 1 |
__________________________________________________________________________|____________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Lymphoma Malignant Mixed | | 1 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Lymphoma Malignant Mixed | | 1 |
__________________________________________________________________________|____________|
Lymph Node | | 1 |
Lumbar, Lymphoma Malignant Mixed | | 1 |
Renal, Lymphoma Malignant Mixed | | 1 |
__________________________________________________________________________|____________|
Lymph Node, Bronchial | + M + M M M + M + M M + + + M M + M + + M + M + M| 25 |
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + M + + M + M + + + + + + + + + M + + M + M M + +| 39 |
Lymphoma Malignant Mixed | | 1 |
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + M + + + + + + + + + A + A + + + + +| 47 |
Lymphoma Malignant Mixed | | 1 |
__________________________________________________________________________|____________|
Lymph Node, Mediastinal | + + + M M + + + + + + + M + + + + + + + + + + + +| 41 |
Lymphoma Malignant Mixed | | 1 |
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hemangioma | X | 1 |
Lymphoma Malignant Mixed | | 1 |
__________________________________________________________________________|____________|
Thymus | + + + + + + + + M + + + + + + + + + M + + + + + +| 45 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | M M M M M M M M M M M M M M + M M M M M M + M M M| 3 |
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Subcutaneous Tissue, Lymphoma | | |
Malignant Mixed | | 1 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 48
NTP Experiment-Test: 05185-04 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC ISOBUTYL NITRITE Date: 03/17/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 18:40:55
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 0| 7| 7| 7| 7| 7| 7| 7| 7| 5| 1| 6| 7| 7| 7| 7| 5| 5| 5| 7| 4| 7| |
DAY ON TEST | 2| 2| 2| 6| 2| 2| 2| 2| 2| 2| 2| 2| 0| 3| 0| 2| 2| 1| 2| 6| 7| 9| 2| 7| 2| |
| 6| 6| 6| 1| 6| 6| 6| 6| 6| 6| 6| 5| 9| 6| 4| 5| 6| 1| 5| 3| 0| 4| 6| 9| 5| |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| A |
CONTROL | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
NERVOUS SYSTEM - cont | | |
| | |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Lymphoma Malignant Mixed | | 1 |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Alveolar/Bronchiolar Adenoma | X X X | 7 |
Alveolar/Bronchiolar Carcinoma | X | 1 |
Hepatocellular Carcinoma, Metastatic,| | |
Liver | X X | 5 |
Lymphoma Malignant Mixed | | 1 |
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Harderian Gland | + | 5 |
Adenoma | X | 4 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Lymphoma Malignant Mixed | | 1 |
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS | | |
__________________________________________________________________________|____________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Lymphoma Malignant Mixed | | 1 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 49
NTP Experiment-Test: 05185-04 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC ISOBUTYL NITRITE Date: 03/17/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 18:40:55
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 5| 7| 7| 7| 7| 1| 7| 7| 7| 7| 7| 7| 7| 6| 6| 7| 5| 7| 7| 3| 6|
DAY ON TEST | 2| 2| 2| 2| 6| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 6| 9| 2| 8| 2| 2| 7| 1|
| 5| 6| 5| 5| 1| 5| 9| 9| 5| 4| 4| 5| 5| 5| 5| 9| 5| 7| 2| 6| 1| 5| 6| 9| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
37.5 PPM | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + M + + + + + +|
__________________________________________________________________________|
Gallbladder | + + M + A + + + + + + + M + + + + A A + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + A + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + A + + + + + + + + + + + + A A + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + A A + + + + + +|
Lymphoma Malignant Mixed | |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + A + + + + + + + + + + + + A A + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Alveolar/Bronchiolar Carcinoma, | |
Metastatic, Lung | |
Hemangiosarcoma | X |
Hemangiosarcoma, Multiple | X |
Hepatocellular Carcinoma | X |
Hepatocellular Carcinoma, Multiple | X |
Hepatocellular Adenoma | X X X X X X X |
Lymphoma Malignant Mixed | |
__________________________________________________________________________|
Mesentery | + |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + A + + + + + +|
Lymphoma Malignant Mixed | X |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + A + + + + + +|
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + A + + + + + +|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Alveolar/Bronchiolar Carcinoma, | |
Metastatic, Lung | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Subcapsular, Adenoma | X |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pheochromocytoma Benign | |
__________________________________________________________________________|
Islets, Pancreatic | + |
Adenoma | |
__________________________________________________________________________|
Parathyroid Gland | M + + + + M + M M + M + + + + M + + + + M M M M +|
__________________________________________________________________________|
Pituitary Gland | M + + + + M + + + M + + + + + I + + + + + + + + +|
Pars Intermedia, Adenoma | |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Alveolar/Bronchiolar Carcinoma, | |
Metastatic, Lung | |
Follicular Cell, Carcinoma | |
_____________________________________________________________________________________________________________________|
Page 50
NTP Experiment-Test: 05185-04 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC ISOBUTYL NITRITE Date: 03/17/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 18:40:55
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 5| 7| 7| 7| 7| 1| 7| 7| 7| 7| 7| 7| 7| 6| 6| 7| 5| 7| 7| 3| 6|
DAY ON TEST | 2| 2| 2| 2| 6| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 6| 9| 2| 8| 2| 2| 7| 1|
| 5| 6| 5| 5| 1| 5| 9| 9| 5| 4| 4| 5| 5| 5| 5| 9| 5| 7| 2| 6| 1| 5| 6| 9| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
37.5 PPM | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Mixed | X |
__________________________________________________________________________|
Penis | +|
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + |
__________________________________________________________________________|
Prostate | + + + + + M + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemangiosarcoma | X |
__________________________________________________________________________|
Lymph Node | + + |
Lymphoma Malignant Mixed | |
Inguinal, Alveolar/Bronchiolar | |
Carcinoma, Metastatic, Lung | |
Renal, Lymphoma Malignant Mixed | |
__________________________________________________________________________|
Lymph Node, Bronchial | + + + + M M + + + + + + + M + + + M M + M + + + +|
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Alveolar/Bronchiolar Carcinoma, | |
Metastatic, Lung | |
__________________________________________________________________________|
Lymph Node, Mesenteric | + M + + + + + + + + + + + + + + + + A + + + + + +|
Lymphoma Malignant Mixed | X |
__________________________________________________________________________|
Lymph Node, Mediastinal | M + + M + + + + + + + + + M + + + + + + M + M +|
Alveolar/Bronchiolar Carcinoma, | |
Metastatic, Lung | |
Hepatocellular Carcinoma, Metastatic,| |
Liver | X |
Lymphoma Malignant Mixed | X |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Mixed | X |
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + + + + + + M + + + + +|
Alveolar/Bronchiolar Carcinoma, | |
Metastatic, Lung | |
Lymphoma Malignant Mixed | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | M M M M M + M M M M M M M M M M M M A M M M M M M|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 51
NTP Experiment-Test: 05185-04 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC ISOBUTYL NITRITE Date: 03/17/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 18:40:55
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 5| 7| 7| 7| 7| 1| 7| 7| 7| 7| 7| 7| 7| 6| 6| 7| 5| 7| 7| 3| 6|
DAY ON TEST | 2| 2| 2| 2| 6| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 6| 9| 2| 8| 2| 2| 7| 1|
| 5| 6| 5| 5| 1| 5| 9| 9| 5| 4| 4| 5| 5| 5| 5| 9| 5| 7| 2| 6| 1| 5| 6| 9| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
37.5 PPM | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM - cont | |
| |
Mandible, Alveolar/Bronchiolar | |
Carcinoma, Metastatic, Lung | |
Rib, Alveolar/Bronchiolar Carcinoma, | |
Metastatic, Lung | |
__________________________________________________________________________|
Skeletal Muscle | |
Alveolar/Bronchiolar Carcinoma, | |
Metastatic, Lung | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Spinal Cord | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Alveolar/Bronchiolar Adenoma | X X X X |
Alveolar/Bronchiolar Adenoma, | |
Multiple | X |
Alveolar/Bronchiolar Carcinoma | X X |
Alveolar/Bronchiolar Carcinoma, | |
Multiple | X |
Hepatocellular Carcinoma, Metastatic,| |
Liver | X X |
Lymphoma Malignant Mixed | X |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Harderian Gland | + |
Adenoma | X |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Alveolar/Bronchiolar Carcinoma, | |
Metastatic, Lung | |
Renal Tubule, Adenoma | X |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + A + + + + + +|
_____________________________________________________________________________________________________________________|
SYSTEMIC LESIONS | |
__________________________________________________________________________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Mixed | X |
_____________________________________________________________________________________________________________________|
Page 52
NTP Experiment-Test: 05185-04 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC ISOBUTYL NITRITE Date: 03/17/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 18:40:55
__________________________________________________________________________________________________________________________________
| 7| 6| 6| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 6| 7| 7| |
DAY ON TEST | 2| 9| 6| 2| 2| 2| 9| 2| 2| 2| 0| 8| 2| 2| 2| 8| 2| 2| 2| 2| 2| 2| 8| 2| 2| |
| 6| 9| 7| 5| 5| 6| 3| 6| 6| 6| 3| 4| 6| 6| 6| 2| 6| 5| 5| 6| 6| 6| 7| 5| 5| |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| A |
37.5 PPM | 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + M M + + + + + + + + + + M + + + + + + + + + + +| 46 |
__________________________________________________________________________|____________|
Gallbladder | + + + + + + A + + M A A + + + A + + + + + + + + +| 40 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + A + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + A + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + A + + + A A + + + + + + + + + M + + +| 45 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + A + + + + A + + + + + + + + + + + + +| 45 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + A + + + A A + + + + + + + + + + + + +| 45 |
Lymphoma Malignant Mixed | X | 1 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + A + + + + A + + + + + + + + + + + + +| 45 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Alveolar/Bronchiolar Carcinoma, | | |
Metastatic, Lung | X | 1 |
Hemangiosarcoma | | 1 |
Hemangiosarcoma, Multiple | | 1 |
Hepatocellular Carcinoma | X X X X| 5 |
Hepatocellular Carcinoma, Multiple | | 1 |
Hepatocellular Adenoma | X X X X X X X X | 15 |
Lymphoma Malignant Mixed | X | 1 |
__________________________________________________________________________|____________|
Mesentery | | 1 |
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Lymphoma Malignant Mixed | | 1 |
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Alveolar/Bronchiolar Carcinoma, | | |
Metastatic, Lung | X | 1 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + M + + + + + + + + + + + + + + + + + + +| 49 |
Subcapsular, Adenoma | | 1 |
__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + M + + + + + + + + + + + + + + + + + + +| 49 |
Pheochromocytoma Benign | X X | 2 |
__________________________________________________________________________|____________|
Islets, Pancreatic | + | 2 |
Adenoma | X | 1 |
__________________________________________________________________________|____________|
Parathyroid Gland | + M M M M M + + + + + + + + + M + + + M + + M + M| 31 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 46 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 53
NTP Experiment-Test: 05185-04 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC ISOBUTYL NITRITE Date: 03/17/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 18:40:55
__________________________________________________________________________________________________________________________________
| 7| 6| 6| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 6| 7| 7| |
DAY ON TEST | 2| 9| 6| 2| 2| 2| 9| 2| 2| 2| 0| 8| 2| 2| 2| 8| 2| 2| 2| 2| 2| 2| 8| 2| 2| |
| 6| 9| 7| 5| 5| 6| 3| 6| 6| 6| 3| 4| 6| 6| 6| 2| 6| 5| 5| 6| 6| 6| 7| 5| 5| |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| A |
37.5 PPM | 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
Pars Intermedia, Adenoma | X| 1 |
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Alveolar/Bronchiolar Carcinoma, | | |
Metastatic, Lung | X | 1 |
Follicular Cell, Carcinoma | X | 1 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Lymphoma Malignant Mixed | | 1 |
__________________________________________________________________________|____________|
Penis | | 1 |
__________________________________________________________________________|____________|
Preputial Gland | + + + + + + + + | 19 |
__________________________________________________________________________|____________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hemangiosarcoma | | 1 |
__________________________________________________________________________|____________|
Lymph Node | + + + | 5 |
Lymphoma Malignant Mixed | X | 1 |
Inguinal, Alveolar/Bronchiolar | | |
Carcinoma, Metastatic, Lung | X | 1 |
Renal, Lymphoma Malignant Mixed | X X | 2 |
__________________________________________________________________________|____________|
Lymph Node, Bronchial | + M + + M + M + + + + M + + M + + + + M + + M M +| 36 |
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Alveolar/Bronchiolar Carcinoma, | | |
Metastatic, Lung | X | 1 |
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
Lymphoma Malignant Mixed | X X | 3 |
__________________________________________________________________________|____________|
Lymph Node, Mediastinal | + + + M + + + + + M M + + + + + + + M M + + M M +| 37 |
Alveolar/Bronchiolar Carcinoma, | | |
Metastatic, Lung | X | 1 |
Hepatocellular Carcinoma, Metastatic,| | |
Liver | | 1 |
Lymphoma Malignant Mixed | X | 2 |
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 54
NTP Experiment-Test: 05185-04 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC ISOBUTYL NITRITE Date: 03/17/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 18:40:55
__________________________________________________________________________________________________________________________________
| 7| 6| 6| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 6| 7| 7| |
DAY ON TEST | 2| 9| 6| 2| 2| 2| 9| 2| 2| 2| 0| 8| 2| 2| 2| 8| 2| 2| 2| 2| 2| 2| 8| 2| 2| |
| 6| 9| 7| 5| 5| 6| 3| 6| 6| 6| 3| 4| 6| 6| 6| 2| 6| 5| 5| 6| 6| 6| 7| 5| 5| |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| A |
37.5 PPM | 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
Lymphoma Malignant Mixed | X X | 3 |
__________________________________________________________________________|____________|
Thymus | + + M + + + + + + + + + + + + + M + + + + M + + +| 46 |
Alveolar/Bronchiolar Carcinoma, | | |
Metastatic, Lung | X | 1 |
Lymphoma Malignant Mixed | X | 1 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | M M M M M M M M M M M M M M M M M M M M M M M M M| 1 |
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Mandible, Alveolar/Bronchiolar | | |
Carcinoma, Metastatic, Lung | X | 1 |
Rib, Alveolar/Bronchiolar Carcinoma, | | |
Metastatic, Lung | X | 1 |
__________________________________________________________________________|____________|
Skeletal Muscle | + | 1 |
Alveolar/Bronchiolar Carcinoma, | | |
Metastatic, Lung | X | 1 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Spinal Cord | + | 1 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Alveolar/Bronchiolar Adenoma | X X X X X | 9 |
Alveolar/Bronchiolar Adenoma, | | |
Multiple | X X | 3 |
Alveolar/Bronchiolar Carcinoma | X X X | 5 |
Alveolar/Bronchiolar Carcinoma, | | |
Multiple | | 1 |
Hepatocellular Carcinoma, Metastatic,| | |
Liver | X X X X| 6 |
Lymphoma Malignant Mixed | | 1 |
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 55
NTP Experiment-Test: 05185-04 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC ISOBUTYL NITRITE Date: 03/17/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 18:40:55
__________________________________________________________________________________________________________________________________
| 7| 6| 6| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 6| 7| 7| |
DAY ON TEST | 2| 9| 6| 2| 2| 2| 9| 2| 2| 2| 0| 8| 2| 2| 2| 8| 2| 2| 2| 2| 2| 2| 8| 2| 2| |
| 6| 9| 7| 5| 5| 6| 3| 6| 6| 6| 3| 4| 6| 6| 6| 2| 6| 5| 5| 6| 6| 6| 7| 5| 5| |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| A |
37.5 PPM | 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM - cont | | |
| | |
| | |
__________________________________________________________________________|____________|
Harderian Gland | | 1 |
Adenoma | | 1 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Alveolar/Bronchiolar Carcinoma, | | |
Metastatic, Lung | X | 1 |
Renal Tubule, Adenoma | | 1 |
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + A + + + + + + + + + + + + + +| 48 |
__________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS | | |
__________________________________________________________________________|____________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Lymphoma Malignant Mixed | X X | 3 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 56
NTP Experiment-Test: 05185-04 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC ISOBUTYL NITRITE Date: 03/17/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 18:40:55
_____________________________________________________________________________________________________________________
| 7| 7| 7| 5| 7| 6| 7| 5| 7| 7| 7| 4| 7| 7| 7| 7| 7| 7| 5| 6| 5| 7| 7| 7| 7|
DAY ON TEST | 2| 2| 2| 6| 2| 1| 2| 5| 2| 2| 2| 0| 2| 2| 2| 2| 2| 2| 5| 6| 5| 2| 2| 2| 2|
| 6| 6| 6| 4| 6| 4| 6| 7| 6| 6| 6| 8| 5| 6| 9| 6| 5| 6| 8| 2| 8| 5| 5| 6| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
75 PPM | 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + M + + + + +|
__________________________________________________________________________|
Gallbladder | + + + + + + + + + M + + + + + + + + + M + + + + M|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + A + + + + + + + + + + + A + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + A + + + + + + + + + + + + + + + + A + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + A + + + +|
Lymphoma Malignant Mixed | |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + A + + + + + + + + + + + A + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cholangiocarcinoma | X |
Hemangiosarcoma | X |
Hepatocellular Carcinoma | X X X X |
Hepatocellular Carcinoma, Multiple | |
Hepatocellular Adenoma | X X X X X X X|
Hepatocellular Adenoma, Multiple | X |
__________________________________________________________________________|
Mesentery | + + + |
Cholangiocarcinoma, Metastatic, Liver| X |
Hemangiosarcoma | X |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Lymphocytic | |
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Tooth | + |
Odontoma | X |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Alveolar/Bronchiolar Carcinoma, | |
Metastatic, Lung | |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Alveolar/Bronchiolar Carcinoma, | |
Metastatic, Lung | |
__________________________________________________________________________|
Islets, Pancreatic | + + |
Adenoma | |
__________________________________________________________________________|
Parathyroid Gland | + + M M M + + M + M + + + + + + + + + + M + + M M|
__________________________________________________________________________|
Pituitary Gland | + + + M + + + I + + + + + + + + + + + + + M + + +|
Pars Distalis, Adenoma | X |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
C-Cell, Carcinoma | X |
_____________________________________________________________________________________________________________________|
Page 57
NTP Experiment-Test: 05185-04 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC ISOBUTYL NITRITE Date: 03/17/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 18:40:55
_____________________________________________________________________________________________________________________
| 7| 7| 7| 5| 7| 6| 7| 5| 7| 7| 7| 4| 7| 7| 7| 7| 7| 7| 5| 6| 5| 7| 7| 7| 7|
DAY ON TEST | 2| 2| 2| 6| 2| 1| 2| 5| 2| 2| 2| 0| 2| 2| 2| 2| 2| 2| 5| 6| 5| 2| 2| 2| 2|
| 6| 6| 6| 4| 6| 4| 6| 7| 6| 6| 6| 8| 5| 6| 9| 6| 5| 6| 8| 2| 8| 5| 5| 6| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
75 PPM | 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | + |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cholangiocarcinoma, Metastatic, Liver| X |
__________________________________________________________________________|
Penis | + |
__________________________________________________________________________|
Preputial Gland | + + + + + + + |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + M + + + + + + + + + + + + +|
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Interstitial Cell, Adenoma | X |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Blood | |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node | + + +|
Inguinal, Cholangiocarcinoma, | |
Metastatic, Liver | X |
Inguinal, Lymphoma Malignant | |
Lymphocytic | |
__________________________________________________________________________|
Lymph Node, Bronchial | M M M M M M + + M M M + + + M M M M M M + M M M +|
Lymphoma Malignant Lymphocytic | |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Lymphocytic | |
Lymphoma Malignant Mixed | |
__________________________________________________________________________|
Lymph Node, Mesenteric | M + + + + + + + + + + + + + + + + + + + + + + M +|
Cholangiocarcinoma, Metastatic, Liver| X |
Lymphoma Malignant Lymphocytic | |
Lymphoma Malignant Mixed | |
__________________________________________________________________________|
Lymph Node, Mediastinal | + + M + + M + + + M + M + M M + + + + + + + + + M|
Cholangiocarcinoma, Metastatic, Liver| X |
Lymphoma Malignant Lymphocytic | |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemangiosarcoma | X |
Lymphoma Malignant Lymphocytic | |
Lymphoma Malignant Mixed | |
__________________________________________________________________________|
Thymus | + + + M + + + M + M + + + + + + + + + M + M + + +|
Lymphoma Malignant Lymphocytic | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | M M M M M M M M M M M M M M M M M M M M M M M M M|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 58
NTP Experiment-Test: 05185-04 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC ISOBUTYL NITRITE Date: 03/17/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 18:40:55
_____________________________________________________________________________________________________________________
| 7| 7| 7| 5| 7| 6| 7| 5| 7| 7| 7| 4| 7| 7| 7| 7| 7| 7| 5| 6| 5| 7| 7| 7| 7|
DAY ON TEST | 2| 2| 2| 6| 2| 1| 2| 5| 2| 2| 2| 0| 2| 2| 2| 2| 2| 2| 5| 6| 5| 2| 2| 2| 2|
| 6| 6| 6| 4| 6| 4| 6| 7| 6| 6| 6| 8| 5| 6| 9| 6| 5| 6| 8| 2| 8| 5| 5| 6| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
75 PPM | 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM - cont | |
| |
Subcutaneous Tissue, | |
Alveolar/Bronchiolar Carcinoma, | |
Metastatic, Lung | |
Subcutaneous Tissue, Schwannoma | |
Malignant, Multiple | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Skeletal Muscle | + |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Larynx | + + + + + + + + + + + + + + + + + + + + + M + + +|
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Alveolar/Bronchiolar Adenoma | X X X X X X X X|
Alveolar/Bronchiolar Adenoma, | |
Multiple | X X |
Alveolar/Bronchiolar Carcinoma | X |
Alveolar/Bronchiolar Carcinoma, | |
Multiple | |
Cholangiocarcinoma, Metastatic, Liver| X |
Hepatocellular Carcinoma, Metastatic,| |
Liver | X |
Mediastinum, Cholangiocarcinoma, | |
Metastatic, Liver | X |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + |
__________________________________________________________________________|
Harderian Gland | + + |
Adenoma | X X |
__________________________________________________________________________|
Zymbal's Gland | + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cholangiocarcinoma, Metastatic, Liver| X |
Hepatocellular Carcinoma, Metastatic,| |
Liver | |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cholangiocarcinoma, Metastatic, Liver| X |
_____________________________________________________________________________________________________________________|
SYSTEMIC LESIONS | |
__________________________________________________________________________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 59
NTP Experiment-Test: 05185-04 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC ISOBUTYL NITRITE Date: 03/17/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 18:40:55
_____________________________________________________________________________________________________________________
| 7| 7| 7| 5| 7| 6| 7| 5| 7| 7| 7| 4| 7| 7| 7| 7| 7| 7| 5| 6| 5| 7| 7| 7| 7|
DAY ON TEST | 2| 2| 2| 6| 2| 1| 2| 5| 2| 2| 2| 0| 2| 2| 2| 2| 2| 2| 5| 6| 5| 2| 2| 2| 2|
| 6| 6| 6| 4| 6| 4| 6| 7| 6| 6| 6| 8| 5| 6| 9| 6| 5| 6| 8| 2| 8| 5| 5| 6| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
75 PPM | 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
SYSTEMIC LESIONS - cont | |
| |
Lymphoma Malignant Lymphocytic | |
Lymphoma Malignant Mixed | |
_____________________________________________________________________________________________________________________|
Page 60
NTP Experiment-Test: 05185-04 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC ISOBUTYL NITRITE Date: 03/17/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 18:40:55
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 5| 7| 4| 7| 7| 7| 3| 7| 7| 6| 7| 6| 6| |
DAY ON TEST | 2| 2| 0| 2| 2| 2| 2| 2| 8| 2| 2| 2| 7| 2| 8| 2| 2| 2| 0| 2| 2| 8| 2| 4| 1| |
| 5| 5| 1| 9| 5| 5| 6| 6| 3| 6| 6| 5| 9| 6| 4| 5| 6| 5| 7| 6| 6| 1| 5| 7| 9| |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| A |
75 PPM | 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Gallbladder | + + + + + M + + A M + + + + A + + M + + + + + + +| 42 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + M + + + + + + + + + A| 48 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + A + + + + + + + + + + + + + + + A| 48 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + A + + + + + A + + + + + + + + + A| 45 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + A + A + + + + + + + + + A| 45 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + A + + + + + A + + + + + + + + + A| 46 |
Lymphoma Malignant Mixed | X | 1 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + A + + + + + A + + + + + + + + + A| 45 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cholangiocarcinoma | | 1 |
Hemangiosarcoma | | 1 |
Hepatocellular Carcinoma | X X X X X | 9 |
Hepatocellular Carcinoma, Multiple | X X| 2 |
Hepatocellular Adenoma | X X X X X X | 13 |
Hepatocellular Adenoma, Multiple | | 1 |
__________________________________________________________________________|____________|
Mesentery | + + | 5 |
Cholangiocarcinoma, Metastatic, Liver| | 1 |
Hemangiosarcoma | | 1 |
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Lymphoma Malignant Lymphocytic | X | 1 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Tooth | | 1 |
Odontoma | | 1 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + M + + + + +| 48 |
Alveolar/Bronchiolar Carcinoma, | | |
Metastatic, Lung | X | 1 |
__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + M + + + + +| 48 |
Alveolar/Bronchiolar Carcinoma, | | |
Metastatic, Lung | X | 1 |
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + | 9 |
Adenoma | X X | 2 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 61
NTP Experiment-Test: 05185-04 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC ISOBUTYL NITRITE Date: 03/17/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 18:40:55
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 5| 7| 4| 7| 7| 7| 3| 7| 7| 6| 7| 6| 6| |
DAY ON TEST | 2| 2| 0| 2| 2| 2| 2| 2| 8| 2| 2| 2| 7| 2| 8| 2| 2| 2| 0| 2| 2| 8| 2| 4| 1| |
| 5| 5| 1| 9| 5| 5| 6| 6| 3| 6| 6| 5| 9| 6| 4| 5| 6| 5| 7| 6| 6| 1| 5| 7| 9| |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| A |
75 PPM | 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + + + + + + + + M + + M M + M M M + M +| 35 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + M + + + + + + + + + +| 46 |
Pars Distalis, Adenoma | | 1 |
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
C-Cell, Carcinoma | | 1 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Tissue NOS | | 1 |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cholangiocarcinoma, Metastatic, Liver| | 1 |
__________________________________________________________________________|____________|
Penis | | 1 |
__________________________________________________________________________|____________|
Preputial Gland | + + + + + + +| 14 |
__________________________________________________________________________|____________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Interstitial Cell, Adenoma | | 1 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood | + | 1 |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + A + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Lymph Node | + + | 5 |
Inguinal, Cholangiocarcinoma, | | |
Metastatic, Liver | | 1 |
Inguinal, Lymphoma Malignant | | |
Lymphocytic | X | 1 |
__________________________________________________________________________|____________|
Lymph Node, Bronchial | M + M M M + M + + M M + M + + + M M + M + M + M M| 18 |
Lymphoma Malignant Lymphocytic | X | 1 |
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Lymphoma Malignant Lymphocytic | X | 1 |
Lymphoma Malignant Mixed | X | 1 |
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + A + + + + + + + + + +| 47 |
Cholangiocarcinoma, Metastatic, Liver| | 1 |
Lymphoma Malignant Lymphocytic | X | 1 |
Lymphoma Malignant Mixed | X | 1 |
__________________________________________________________________________|____________|
Lymph Node, Mediastinal | + + + + + + + + + M + + M + A M + + + + + + + + +| 39 |
Cholangiocarcinoma, Metastatic, Liver| | 1 |
Lymphoma Malignant Lymphocytic | X | 1 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 62
NTP Experiment-Test: 05185-04 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC ISOBUTYL NITRITE Date: 03/17/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 18:40:55
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 5| 7| 4| 7| 7| 7| 3| 7| 7| 6| 7| 6| 6| |
DAY ON TEST | 2| 2| 0| 2| 2| 2| 2| 2| 8| 2| 2| 2| 7| 2| 8| 2| 2| 2| 0| 2| 2| 8| 2| 4| 1| |
| 5| 5| 1| 9| 5| 5| 6| 6| 3| 6| 6| 5| 9| 6| 4| 5| 6| 5| 7| 6| 6| 1| 5| 7| 9| |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| A |
75 PPM | 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + A + + + + + + + + + +| 49 |
Hemangiosarcoma | | 1 |
Lymphoma Malignant Lymphocytic | X | 1 |
Lymphoma Malignant Mixed | X | 1 |
__________________________________________________________________________|____________|
Thymus | + + + + M + M + + + + + + M A + + + M M M + + + +| 38 |
Lymphoma Malignant Lymphocytic | X | 1 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | M M M M M M M M M M M M M M M M M M + M M M M M M| 1 |
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + A + + + + + + + + + +| 49 |
Subcutaneous Tissue, | | |
Alveolar/Bronchiolar Carcinoma, | | |
Metastatic, Lung | X | 1 |
Subcutaneous Tissue, Schwannoma | | |
Malignant, Multiple | X | 1 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Skeletal Muscle | | 1 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + A + + + + + + + + + +| 49 |
Alveolar/Bronchiolar Adenoma | X X | 10 |
Alveolar/Bronchiolar Adenoma, | | |
Multiple | X | 3 |
Alveolar/Bronchiolar Carcinoma | X X X | 4 |
Alveolar/Bronchiolar Carcinoma, | | |
Multiple | X | 1 |
Cholangiocarcinoma, Metastatic, Liver| | 1 |
Hepatocellular Carcinoma, Metastatic,| | |
Liver | X X X| 4 |
Mediastinum, Cholangiocarcinoma, | | |
Metastatic, Liver | | 1 |
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 63
NTP Experiment-Test: 05185-04 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC ISOBUTYL NITRITE Date: 03/17/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 18:40:55
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 5| 7| 4| 7| 7| 7| 3| 7| 7| 6| 7| 6| 6| |
DAY ON TEST | 2| 2| 0| 2| 2| 2| 2| 2| 8| 2| 2| 2| 7| 2| 8| 2| 2| 2| 0| 2| 2| 8| 2| 4| 1| |
| 5| 5| 1| 9| 5| 5| 6| 6| 3| 6| 6| 5| 9| 6| 4| 5| 6| 5| 7| 6| 6| 1| 5| 7| 9| |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| A |
75 PPM | 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont | | |
| | |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | | 1 |
__________________________________________________________________________|____________|
Harderian Gland | + | 3 |
Adenoma | X | 3 |
__________________________________________________________________________|____________|
Zymbal's Gland | | 1 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cholangiocarcinoma, Metastatic, Liver| | 1 |
Hepatocellular Carcinoma, Metastatic,| | |
Liver | X | 1 |
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + A +| 49 |
Cholangiocarcinoma, Metastatic, Liver| | 1 |
__________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS | | |
__________________________________________________________________________|____________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Lymphoma Malignant Lymphocytic | X | 1 |
Lymphoma Malignant Mixed | X | 1 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 64
NTP Experiment-Test: 05185-04 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC ISOBUTYL NITRITE Date: 03/17/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 18:40:55
_____________________________________________________________________________________________________________________
| 6| 7| 7| 6| 7| 7| 5| 7| 4| 7| 5| 6| 7| 7| 7| 5| 7| 5| 2| 7| 5| 7| 7| 7| 7|
DAY ON TEST | 2| 2| 2| 4| 2| 2| 7| 2| 4| 2| 5| 6| 2| 2| 2| 5| 2| 4| 3| 2| 8| 2| 2| 2| 2|
| 5| 5| 6| 0| 5| 6| 5| 5| 3| 5| 3| 8| 5| 5| 5| 8| 6| 1| 5| 4| 8| 6| 9| 6| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
150 PPM | 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | + + + + + + A + + + + A + + + + + A A + A + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + A + + + + + + + + A A + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + A + + A + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | A + + A + + + + A + + A + + + + + A A + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | A + + + + + + + A + + A + + + + + A A + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + A + + A + A + + A + + M + + A A + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | A + + A + + + + A + + A + + + + + A A + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemangiosarcoma | X X |
Hemangiosarcoma, Multiple | |
Hepatocellular Carcinoma | X X X X X X|
Hepatocellular Adenoma | X X X X X X X X X|
Hepatocellular Adenoma, Multiple | |
__________________________________________________________________________|
Mesentery | + + |
__________________________________________________________________________|
Pancreas | + + + + + + + + A + + + + + + + + A A + + + + + +|
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + A + + + + + + + + A A + + + + + +|
Squamous Cell Carcinoma | X |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + A + + + + + + + + A A + + + + + +|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + A + + + + M + + + + + + + + + + +|
Subcapsular, Adenoma | |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + A + + + + M + + + + + + + + + + +|
Pheochromocytoma Benign | |
__________________________________________________________________________|
Islets, Pancreatic | |
__________________________________________________________________________|
Parathyroid Gland | + M + M + + + + + + + M + M M + + + + + + + + + M|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + M M + + + + M + + + + + + M|
Pars Distalis, Adenoma | |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Bilateral, Follicular Cell, Adenoma | |
Follicular Cell, Adenoma | X |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Coagulating Gland | A |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Penis | + + |
_____________________________________________________________________________________________________________________|
Page 65
NTP Experiment-Test: 05185-04 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC ISOBUTYL NITRITE Date: 03/17/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 18:40:55
_____________________________________________________________________________________________________________________
| 6| 7| 7| 6| 7| 7| 5| 7| 4| 7| 5| 6| 7| 7| 7| 5| 7| 5| 2| 7| 5| 7| 7| 7| 7|
DAY ON TEST | 2| 2| 2| 4| 2| 2| 7| 2| 4| 2| 5| 6| 2| 2| 2| 5| 2| 4| 3| 2| 8| 2| 2| 2| 2|
| 5| 5| 6| 0| 5| 6| 5| 5| 3| 5| 3| 8| 5| 5| 5| 8| 6| 1| 5| 4| 8| 6| 9| 6| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
150 PPM | 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
__________________________________________________________________________|
Preputial Gland | + + + + + +|
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + A + + + + + + +|
__________________________________________________________________________|
Lymph Node | + + |
Inguinal, Lymphoma Malignant Mixed | X |
Lumbar, Lymphoma Malignant Mixed | X |
__________________________________________________________________________|
Lymph Node, Bronchial | + + + + M M M + + + + M + M + + M + + M M + + + M|
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + M + + + + + M + + + + + + + + M + +|
Lymphoma Malignant Lymphocytic | X |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + A + + + + + + + + A A + + + + + +|
Lymphoma Malignant Lymphocytic | X |
Lymphoma Malignant Mixed | X |
__________________________________________________________________________|
Lymph Node, Mediastinal | + + + + + M + M M + + + M + M + + + + + M M + + +|
Lymphoma Malignant Lymphocytic | X |
Lymphoma Malignant Mixed | X |
__________________________________________________________________________|
Spleen | + + + + + + + + A + + + + + + + + A + + + + + + +|
Sarcoma, Metastatic, Skin | |
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + M + M + A + M + + + + M|
Lymphoma Malignant Mixed | X |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | M M M M M M M M M M M M M M M M M M M M M M M M M|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + A + + + + + + +|
Subcutaneous Tissue, Sarcoma | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Larynx | + + M + + + M + I + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Alveolar/Bronchiolar Adenoma | X X X X X |
Alveolar/Bronchiolar Adenoma, | |
Multiple | X X|
Alveolar/Bronchiolar Carcinoma | X |
Hepatocellular Carcinoma, Metastatic,| |
Liver | X|
_____________________________________________________________________________________________________________________|
Page 66
NTP Experiment-Test: 05185-04 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC ISOBUTYL NITRITE Date: 03/17/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 18:40:55
_____________________________________________________________________________________________________________________
| 6| 7| 7| 6| 7| 7| 5| 7| 4| 7| 5| 6| 7| 7| 7| 5| 7| 5| 2| 7| 5| 7| 7| 7| 7|
DAY ON TEST | 2| 2| 2| 4| 2| 2| 7| 2| 4| 2| 5| 6| 2| 2| 2| 5| 2| 4| 3| 2| 8| 2| 2| 2| 2|
| 5| 5| 6| 0| 5| 6| 5| 5| 3| 5| 3| 8| 5| 5| 5| 8| 6| 1| 5| 4| 8| 6| 9| 6| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
150 PPM | 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
Sarcoma, Metastatic, Skin | |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Glands, Adenoma | |
__________________________________________________________________________|
Trachea | + + + + + + + + A + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | |
__________________________________________________________________________|
Harderian Gland | + + |
Adenocarcinoma | |
Adenoma | X X |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + A + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SYSTEMIC LESIONS | |
__________________________________________________________________________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Lymphocytic | X |
Lymphoma Malignant Mixed | X |
_____________________________________________________________________________________________________________________|
Page 67
NTP Experiment-Test: 05185-04 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC ISOBUTYL NITRITE Date: 03/17/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 18:40:55
_____________________________________________________________________________________________________________________
| 7| 7| 7| 5| 7| 3| 7| 7| 7| 7| 7| 7| 6| 5| 7| 7| 6| 7| 7| 7| 1| 5| 7| 7| 5|
DAY ON TEST | 2| 2| 2| 5| 1| 1| 2| 2| 2| 2| 2| 2| 9| 5| 2| 2| 9| 2| 2| 2| 0| 5| 2| 2| 3|
| 5| 5| 5| 8| 8| 6| 5| 9| 5| 5| 6| 5| 3| 2| 5| 6| 2| 5| 5| 6| 0| 6| 5| 6| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
150 PPM | 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1|
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | + + + + + + + + + + + + A + + + + + + + A + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + A + + + + + + + A + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + A + + + + + + + A + + + A|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + A + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + A + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemangiosarcoma | |
Hemangiosarcoma, Multiple | X |
Hepatocellular Carcinoma | X X X |
Hepatocellular Adenoma | X X X X |
Hepatocellular Adenoma, Multiple | X |
__________________________________________________________________________|
Mesentery | |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Squamous Cell Carcinoma | |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Subcapsular, Adenoma | X |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pheochromocytoma Benign | X |
__________________________________________________________________________|
Islets, Pancreatic | + |
__________________________________________________________________________|
Parathyroid Gland | + + + M + M + + M + + + M M + M + M + + + M + + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + M + M + + + + +|
Pars Distalis, Adenoma | X |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Bilateral, Follicular Cell, Adenoma | X |
Follicular Cell, Adenoma | X X X |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Coagulating Gland | |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Penis | + +|
_____________________________________________________________________________________________________________________|
Page 68
NTP Experiment-Test: 05185-04 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC ISOBUTYL NITRITE Date: 03/17/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 18:40:55
_____________________________________________________________________________________________________________________
| 7| 7| 7| 5| 7| 3| 7| 7| 7| 7| 7| 7| 6| 5| 7| 7| 6| 7| 7| 7| 1| 5| 7| 7| 5|
DAY ON TEST | 2| 2| 2| 5| 1| 1| 2| 2| 2| 2| 2| 2| 9| 5| 2| 2| 9| 2| 2| 2| 0| 5| 2| 2| 3|
| 5| 5| 5| 8| 8| 6| 5| 9| 5| 5| 6| 5| 3| 2| 5| 6| 2| 5| 5| 6| 0| 6| 5| 6| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
150 PPM | 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1|
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
__________________________________________________________________________|
Preputial Gland | + + + + + + |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node | + + + |
Inguinal, Lymphoma Malignant Mixed | |
Lumbar, Lymphoma Malignant Mixed | |
__________________________________________________________________________|
Lymph Node, Bronchial | + M + + + M + + M + + + M + + M M M + M M + + + +|
__________________________________________________________________________|
Lymph Node, Mandibular | + + M + + + + + + + + + + + + + + M + + + + + + +|
Lymphoma Malignant Lymphocytic | |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Lymphocytic | |
Lymphoma Malignant Mixed | |
__________________________________________________________________________|
Lymph Node, Mediastinal | M M M + + + M M + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Lymphocytic | |
Lymphoma Malignant Mixed | |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Sarcoma, Metastatic, Skin | X |
__________________________________________________________________________|
Thymus | + + M + M + + + + + M + + + + + + + + + M + + + +|
Lymphoma Malignant Mixed | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | M M M M M M M M M M M M M M M M M M M M M M M M M|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Subcutaneous Tissue, Sarcoma | X |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Alveolar/Bronchiolar Adenoma | X X X X X X X |
Alveolar/Bronchiolar Adenoma, | |
Multiple | X X X |
Alveolar/Bronchiolar Carcinoma | X X X |
Hepatocellular Carcinoma, Metastatic,| |
Liver | |
_____________________________________________________________________________________________________________________|
Page 69
NTP Experiment-Test: 05185-04 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC ISOBUTYL NITRITE Date: 03/17/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 18:40:55
_____________________________________________________________________________________________________________________
| 7| 7| 7| 5| 7| 3| 7| 7| 7| 7| 7| 7| 6| 5| 7| 7| 6| 7| 7| 7| 1| 5| 7| 7| 5|
DAY ON TEST | 2| 2| 2| 5| 1| 1| 2| 2| 2| 2| 2| 2| 9| 5| 2| 2| 9| 2| 2| 2| 0| 5| 2| 2| 3|
| 5| 5| 5| 8| 8| 6| 5| 9| 5| 5| 6| 5| 3| 2| 5| 6| 2| 5| 5| 6| 0| 6| 5| 6| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
150 PPM | 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1|
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
Sarcoma, Metastatic, Skin | X |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Glands, Adenoma | |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + + |
__________________________________________________________________________|
Harderian Gland | + + + + |
Adenocarcinoma | X |
Adenoma | X X X |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + A + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SYSTEMIC LESIONS | |
__________________________________________________________________________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Lymphocytic | |
Lymphoma Malignant Mixed | |
_____________________________________________________________________________________________________________________|
Page 70
NTP Experiment-Test: 05185-04 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC ISOBUTYL NITRITE Date: 03/17/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 18:40:55
__________________________________________________________________________________________________________________________________
| 3| 0| 2| | |
DAY ON TEST | 0| 9| 9| | |
| 0| 6| 6| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| | T |
ANIMAL ID | 4| 4| 4| | A |
150 PPM | 1| 1| 1| | L |
| 1| 2| 6| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + | 53 |
__________________________________________________________________________|____________|
Gallbladder | + + + | 46 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + A | 49 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | A + A | 49 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | A + A | 43 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | A + A | 43 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | A + A | 43 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | A A A | 43 |
__________________________________________________________________________|____________|
Liver | + + + | 53 |
Hemangiosarcoma | | 2 |
Hemangiosarcoma, Multiple | | 1 |
Hepatocellular Carcinoma | | 9 |
Hepatocellular Adenoma | | 13 |
Hepatocellular Adenoma, Multiple | | 1 |
__________________________________________________________________________|____________|
Mesentery | | 2 |
__________________________________________________________________________|____________|
Pancreas | + + A | 49 |
__________________________________________________________________________|____________|
Salivary Glands | + + + | 53 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + A | 49 |
Squamous Cell Carcinoma | | 1 |
__________________________________________________________________________|____________|
Stomach, Glandular | + + A | 49 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + | 53 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + + | 51 |
Subcapsular, Adenoma | | 1 |
__________________________________________________________________________|____________|
Adrenal Medulla | + + + | 51 |
Pheochromocytoma Benign | | 1 |
__________________________________________________________________________|____________|
Islets, Pancreatic | | 1 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + + | 39 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + | 47 |
Pars Distalis, Adenoma | | 1 |
__________________________________________________________________________|____________|
Thyroid Gland | + + + | 53 |
Bilateral, Follicular Cell, Adenoma | | 1 |
Follicular Cell, Adenoma | | 4 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 71
NTP Experiment-Test: 05185-04 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC ISOBUTYL NITRITE Date: 03/17/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 18:40:55
__________________________________________________________________________________________________________________________________
| 3| 0| 2| | |
DAY ON TEST | 0| 9| 9| | |
| 0| 6| 6| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| | T |
ANIMAL ID | 4| 4| 4| | A |
150 PPM | 1| 1| 1| | L |
| 1| 2| 6| | |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Coagulating Gland | | |
__________________________________________________________________________|____________|
Epididymis | + + + | 53 |
__________________________________________________________________________|____________|
Penis | + | 5 |
__________________________________________________________________________|____________|
Preputial Gland | | 12 |
__________________________________________________________________________|____________|
Prostate | + + + | 53 |
__________________________________________________________________________|____________|
Seminal Vesicle | + + + | 53 |
__________________________________________________________________________|____________|
Testes | + + + | 53 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + | 52 |
__________________________________________________________________________|____________|
Lymph Node | | 5 |
Inguinal, Lymphoma Malignant Mixed | | 1 |
Lumbar, Lymphoma Malignant Mixed | | 1 |
__________________________________________________________________________|____________|
Lymph Node, Bronchial | + + M | 34 |
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + | 48 |
Lymphoma Malignant Lymphocytic | | 1 |
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | A + + | 49 |
Lymphoma Malignant Lymphocytic | | 1 |
Lymphoma Malignant Mixed | | 1 |
__________________________________________________________________________|____________|
Lymph Node, Mediastinal | + + + | 41 |
Lymphoma Malignant Lymphocytic | | 1 |
Lymphoma Malignant Mixed | | 1 |
__________________________________________________________________________|____________|
Spleen | + + + | 51 |
Sarcoma, Metastatic, Skin | | 1 |
__________________________________________________________________________|____________|
Thymus | + + M | 43 |
Lymphoma Malignant Mixed | | 1 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | M M M | |
__________________________________________________________________________|____________|
Skin | + + + | 52 |
Subcutaneous Tissue, Sarcoma | | 1 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + | 53 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + | 53 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 72
NTP Experiment-Test: 05185-04 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC ISOBUTYL NITRITE Date: 03/17/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 18:40:55
__________________________________________________________________________________________________________________________________
| 3| 0| 2| | |
DAY ON TEST | 0| 9| 9| | |
| 0| 6| 6| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| | T |
ANIMAL ID | 4| 4| 4| | A |
150 PPM | 1| 1| 1| | L |
| 1| 2| 6| | |
__________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Larynx | + + + | 50 |
__________________________________________________________________________|____________|
Lung | + + + | 53 |
Alveolar/Bronchiolar Adenoma | | 12 |
Alveolar/Bronchiolar Adenoma, | | |
Multiple | | 5 |
Alveolar/Bronchiolar Carcinoma | | 4 |
Hepatocellular Carcinoma, Metastatic,| | |
Liver | | 1 |
Sarcoma, Metastatic, Skin | | 1 |
__________________________________________________________________________|____________|
Nose | + + + | 53 |
Glands, Adenoma | X | 1 |
__________________________________________________________________________|____________|
Trachea | + + + | 52 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | | 2 |
__________________________________________________________________________|____________|
Harderian Gland | | 6 |
Adenocarcinoma | | 1 |
Adenoma | | 5 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + | 53 |
__________________________________________________________________________|____________|
Urinary Bladder | + + A | 50 |
__________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS | | |
__________________________________________________________________________|____________|
Multiple Organs | + + + | 53 |
Lymphoma Malignant Lymphocytic | | 1 |
Lymphoma Malignant Mixed | | 1 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 73
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---------- END OF REPORT ----------
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