Skip to Main Navigation
Skip to Page Content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Share This:
https://ntp.niehs.nih.gov/go/4568

TDMS Study 05186-04 Pathology Tables

NTP Experiment-Test: 05186-04         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: SUBCHRON 90-DAY                                    CARISOPRODOL                                       Date: 04/06/98
Route: GAVAGE                                                                                                     Time: 14:04:04




       Facility:  Battelle Columbus Laboratory

       Chemical CAS #:  78-44-4

       Lock Date:  04/13/93

       Cage Range:  All

       Reasons For Removal:    All

       Removal Date Range:     All

       Treatment Groups:       Include All




































a  Number of animals examined microscopically at site and number of animals with lesion

                                                              Page   1


NTP Experiment-Test: 05186-04         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: SUBCHRON 90-DAY                                    CARISOPRODOL                                       Date: 04/06/98  
Route: GAVAGE                                                                                                     Time: 14:04:04  
____________________________________________________________________________________________________________________________________

         B6C3F1 MICE FEMALE                        0 MG/KG      600          1200         1600                                      
                                                                MG/KG        MG/KG        MG/KG                                     
____________________________________________________________________________________________________________________________________

DISPOSITION SUMMARY                                                                                                                 


  Animals Initially In Study                          10           10           10           10                                     
  Early Deaths                                                                                                                      
    Dosing Accident                                    1                         2                                                  
    Natural Death                                                                             1                                     
  Survivors                                                                                                                         
    Terminal Sacrifice                                 9           10            8            9                                     

  Animals Examined Microscopically                    10           10           10           10                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Liver                                              (10)         (10)         (10)         (10)                                   
      Inflammation, Granulomatous                      2 (20%)      3 (30%)      3 (30%)                                            
      Centrilobular, Hypertrophy                                                 8 (80%)      9 (90%)                               
      Hepatocyte, Necrosis                             1 (10%)                                                                      
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Heart                                              (1)                       (2)          (1)                                    
      Epicardium, Foreign Body                         1 (100%)                                                                     
      Epicardium, Inflammation, Suppurative            1 (100%)                  1 (50%)                                            
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Thymus                                             (1)                       (2)          (1)                                    
      Foreign Body                                     1 (100%)                                                                     
      Inflammation, Suppurative                        1 (100%)                  1 (50%)                                            
      Thymocyte, Autolysis                                                       1 (50%)                                            

a  Number of animals examined microscopically at site and number of animals with lesion                                             
NTP Experiment-Test: 05186-04         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: SUBCHRON 90-DAY                                    CARISOPRODOL                                       Date: 04/06/98  
Route: GAVAGE                                                                                                     Time: 14:04:04  
____________________________________________________________________________________________________________________________________

         B6C3F1 MICE FEMALE                        0 MG/KG      600          1200         1600                                      
                                                                MG/KG        MG/KG        MG/KG                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
HEMATOPOIETIC SYSTEM - CONT                                                                                                         
      Thymocyte, Necrosis                                                        1 (50%)                                            
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (1)                       (2)          (1)                                    
      Congestion, Acute                                                          1 (50%)                                            
      Mediastinum, Foreign Body                        1 (100%)                  1 (50%)                                            
      Mediastinum, Inflammation, Suppurative           1 (100%)                  2 (100%)                                           
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   None                                                                                                                             

a  Number of animals examined microscopically at site and number of animals with lesion                                             
NTP Experiment-Test: 05186-04         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: SUBCHRON 90-DAY                                    CARISOPRODOL                                       Date: 04/06/98  
Route: GAVAGE                                                                                                     Time: 14:04:04  
____________________________________________________________________________________________________________________________________

         B6C3F1 MICE MALE                          0 MG/KG      600          1200         1600                                      
                                                                MG/KG        MG/KG        MG/KG                                     
____________________________________________________________________________________________________________________________________

DISPOSITION SUMMARY                                                                                                                 


  Animals Initially In Study                          10           10           10           10                                     
  Early Deaths                                                                                                                      
    Dosing Accident                                    1            1                         2                                     
    Natural Death                                                                             1                                     
  Survivors                                                                                                                         
    Terminal Sacrifice                                 9            9           10            7                                     

  Animals Examined Microscopically                    10           10           10           10                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Esophagus                                          (1)          (1)                       (3)                                    
      Muscularis, Inflammation, Chronic Active                      1 (100%)                                                        
   Liver                                              (10)         (10)         (10)         (10)                                   
      Hematopoietic Cell Proliferation                 1 (10%)                                                                      
      Inflammation, Granulomatous                      1 (10%)                                                                      
      Centrilobular, Hypertrophy                                    9 (90%)     10 (100%)     7 (70%)                               
   Salivary Glands                                    (1)          (1)                       (3)                                    
      Inflammation, Chronic Active                     1 (100%)                                                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Heart                                              (1)          (1)                       (3)                                    
      Epicardium, Foreign Body                         1 (100%)                                                                     
      Epicardium, Inflammation, Suppurative            1 (100%)                                                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    

a  Number of animals examined microscopically at site and number of animals with lesion                                             
NTP Experiment-Test: 05186-04         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: SUBCHRON 90-DAY                                    CARISOPRODOL                                       Date: 04/06/98  
Route: GAVAGE                                                                                                     Time: 14:04:04  
____________________________________________________________________________________________________________________________________

         B6C3F1 MICE MALE                          0 MG/KG      600          1200         1600                                      
                                                                MG/KG        MG/KG        MG/KG                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Spleen                                             (1)          (1)                       (3)                                    
      Hematopoietic Cell Proliferation                 1 (100%)                                                                     
   Thymus                                             (1)          (1)                       (3)                                    
      Inflammation, Granulomatous                      1 (100%)                                                                     
      Thymocyte, Autolysis                                                                    3 (100%)                              
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (1)          (1)                       (3)                                    
      Inflammation, Chronic Active                     1 (100%)                                                                     
      Inflammation, Suppurative                                                               1 (33%)                               
      Mediastinum, Foreign Body                        1 (100%)                               1 (33%)                               
      Mediastinum, Inflammation, Suppurative                                                  2 (67%)                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (10)         (1)                       (10)                                   
      Inflammation, Chronic Active                     1 (10%)                                                                      
      Renal Tubule, Regeneration                       2 (20%)                                2 (20%)                               
                                                                                                                                    

a  Number of animals examined microscopically at site and number of animals with lesion                                             
                             ------------------------------------------------------------                                           
                             ----------              END OF REPORT             ----------                                           
                             ------------------------------------------------------------