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TDMS Study 05186-04 Pathology Tables

NTP Experiment-Test: 05186-04         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: SUBCHRON 90-DAY                                    CARISOPRODOL                                       Date: 04/06/98
Route: GAVAGE                                                                                                     Time: 14:04:04




       Facility:  Battelle Columbus Laboratory

       Chemical CAS #:  78-44-4

       Lock Date:  04/13/93

       Cage Range:  All

       Reasons For Removal:    All

       Removal Date Range:     All

       Treatment Groups:       Include All




































a  Number of animals examined microscopically at site and number of animals with lesion

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NTP Experiment-Test: 05186-04         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: SUBCHRON 90-DAY                                    CARISOPRODOL                                       Date: 04/06/98  
Route: GAVAGE                                                                                                     Time: 14:04:04  
____________________________________________________________________________________________________________________________________

         B6C3F1 MICE FEMALE                        0 MG/KG      600          1200         1600                                      
                                                                MG/KG        MG/KG        MG/KG                                     
____________________________________________________________________________________________________________________________________

DISPOSITION SUMMARY                                                                                                                 


  Animals Initially In Study                          10           10           10           10                                     
  Early Deaths                                                                                                                      
    Dosing Accident                                    1                         2                                                  
    Natural Death                                                                             1                                     
  Survivors                                                                                                                         
    Terminal Sacrifice                                 9           10            8            9                                     

  Animals Examined Microscopically                    10           10           10           10                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Liver                                              (10)         (10)         (10)         (10)                                   
      Inflammation, Granulomatous                      2 (20%)      3 (30%)      3 (30%)                                            
      Centrilobular, Hypertrophy                                                 8 (80%)      9 (90%)                               
      Hepatocyte, Necrosis                             1 (10%)                                                                      
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Heart                                              (1)                       (2)          (1)                                    
      Epicardium, Foreign Body                         1 (100%)                                                                     
      Epicardium, Inflammation, Suppurative            1 (100%)                  1 (50%)                                            
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Thymus                                             (1)                       (2)          (1)                                    
      Foreign Body                                     1 (100%)                                                                     
      Inflammation, Suppurative                        1 (100%)                  1 (50%)                                            
      Thymocyte, Autolysis                                                       1 (50%)                                            

a  Number of animals examined microscopically at site and number of animals with lesion                                             
NTP Experiment-Test: 05186-04         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: SUBCHRON 90-DAY                                    CARISOPRODOL                                       Date: 04/06/98  
Route: GAVAGE                                                                                                     Time: 14:04:04  
____________________________________________________________________________________________________________________________________

         B6C3F1 MICE FEMALE                        0 MG/KG      600          1200         1600                                      
                                                                MG/KG        MG/KG        MG/KG                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
HEMATOPOIETIC SYSTEM - CONT                                                                                                         
      Thymocyte, Necrosis                                                        1 (50%)                                            
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (1)                       (2)          (1)                                    
      Congestion, Acute                                                          1 (50%)                                            
      Mediastinum, Foreign Body                        1 (100%)                  1 (50%)                                            
      Mediastinum, Inflammation, Suppurative           1 (100%)                  2 (100%)                                           
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   None                                                                                                                             

a  Number of animals examined microscopically at site and number of animals with lesion                                             
NTP Experiment-Test: 05186-04         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: SUBCHRON 90-DAY                                    CARISOPRODOL                                       Date: 04/06/98  
Route: GAVAGE                                                                                                     Time: 14:04:04  
____________________________________________________________________________________________________________________________________

         B6C3F1 MICE MALE                          0 MG/KG      600          1200         1600                                      
                                                                MG/KG        MG/KG        MG/KG                                     
____________________________________________________________________________________________________________________________________

DISPOSITION SUMMARY                                                                                                                 


  Animals Initially In Study                          10           10           10           10                                     
  Early Deaths                                                                                                                      
    Dosing Accident                                    1            1                         2                                     
    Natural Death                                                                             1                                     
  Survivors                                                                                                                         
    Terminal Sacrifice                                 9            9           10            7                                     

  Animals Examined Microscopically                    10           10           10           10                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Esophagus                                          (1)          (1)                       (3)                                    
      Muscularis, Inflammation, Chronic Active                      1 (100%)                                                        
   Liver                                              (10)         (10)         (10)         (10)                                   
      Hematopoietic Cell Proliferation                 1 (10%)                                                                      
      Inflammation, Granulomatous                      1 (10%)                                                                      
      Centrilobular, Hypertrophy                                    9 (90%)     10 (100%)     7 (70%)                               
   Salivary Glands                                    (1)          (1)                       (3)                                    
      Inflammation, Chronic Active                     1 (100%)                                                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Heart                                              (1)          (1)                       (3)                                    
      Epicardium, Foreign Body                         1 (100%)                                                                     
      Epicardium, Inflammation, Suppurative            1 (100%)                                                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    

a  Number of animals examined microscopically at site and number of animals with lesion                                             
NTP Experiment-Test: 05186-04         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: SUBCHRON 90-DAY                                    CARISOPRODOL                                       Date: 04/06/98  
Route: GAVAGE                                                                                                     Time: 14:04:04  
____________________________________________________________________________________________________________________________________

         B6C3F1 MICE MALE                          0 MG/KG      600          1200         1600                                      
                                                                MG/KG        MG/KG        MG/KG                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Spleen                                             (1)          (1)                       (3)                                    
      Hematopoietic Cell Proliferation                 1 (100%)                                                                     
   Thymus                                             (1)          (1)                       (3)                                    
      Inflammation, Granulomatous                      1 (100%)                                                                     
      Thymocyte, Autolysis                                                                    3 (100%)                              
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (1)          (1)                       (3)                                    
      Inflammation, Chronic Active                     1 (100%)                                                                     
      Inflammation, Suppurative                                                               1 (33%)                               
      Mediastinum, Foreign Body                        1 (100%)                               1 (33%)                               
      Mediastinum, Inflammation, Suppurative                                                  2 (67%)                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (10)         (1)                       (10)                                   
      Inflammation, Chronic Active                     1 (10%)                                                                      
      Renal Tubule, Regeneration                       2 (20%)                                2 (20%)                               
                                                                                                                                    

a  Number of animals examined microscopically at site and number of animals with lesion                                             
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                             ----------              END OF REPORT             ----------                                           
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