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TDMS Study 05186-04 Pathology Tables

NTP Experiment-Test: 05186-04                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: SUBCHRON 90-DAY                                    CARISOPRODOL                                       Date: 04/06/98
Route: GAVAGE                                                                                                     Time: 14:02:50




       Facility:  Battelle Columbus Laboratory

       Chemical CAS #:  78-44-4

       Lock Date:  04/13/93

       Cage Range:  All

       Reasons For Removal:    All

       Removal Date Range:     All

       Treatment Groups:       Include All






































                                                              Page   1



NTP Experiment-Test: 05186-04                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: SUBCHRON 90-DAY                                    CARISOPRODOL                                       Date: 04/06/98  
Route: GAVAGE                                                                                                     Time: 14:02:50  
                                                                                                                                    

 __________________________________________________________________________________________________________________________________ 
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |            |
                             DAY ON TEST   | 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|                                            |            |
                                           | 2| 2| 2| 2| 2| 2| 2| 2| 2| 7|                                            |      T (*) |

 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      A     |
    0 MG/KG                                | 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|                                            |      L     |
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                                            |            |

 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Esophagus                               |                            +                                             |   1        |

                                            __________________________________________________________________________|____________|
   Gallbladder                             |                            +                                             |   1        |

                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  |                            A                                             |            |

                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 |                            A                                             |            |

                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  |                            A                                             |            |

                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               |                            A                                             |            |

                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                |                            A                                             |            |

                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  |                            A                                             |            |

                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +                                             |  10        |
      Inflammation, Granulomatous          |       1           1                                                      |      2  1.0|
      Hepatocyte, Necrosis                 |          1                                                               |      1  1.0|

                                            __________________________________________________________________________|____________|
   Pancreas                                |                            A                                             |            |

                                            __________________________________________________________________________|____________|
   Salivary Glands                         |                            +                                             |   1        |

                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    |                            +                                             |   1        |

                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      |                            A                                             |            |

 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Blood Vessel                            |                            +                                             |   1        |

                                            __________________________________________________________________________|____________|
   Heart                                   |                            +                                             |   1        |
      Epicardium, Foreign Body             |                            3                                             |      1  3.0|
      Epicardium, Inflammation, Suppurative|                            3                                             |      1  3.0|

 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Adrenal Cortex                          |                            +                                             |   1        |

                                            __________________________________________________________________________|____________|
   Adrenal Medulla                         |                            +                                             |   1        |

                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      |                            +                                             |   1        |

                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       |                            M                                             |            |

                                            __________________________________________________________________________|____________|
   Pituitary Gland                         |                            +                                             |   1        |

                                            __________________________________________________________________________|____________|
   Thyroid Gland                           |                            M                                             |            |

 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |

 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Clitoral Gland                          |                            +                                             |   1        |

                                            __________________________________________________________________________|____________|
   Ovary                                   |                            +                                             |   1        |

                                            __________________________________________________________________________|____________|
   Uterus                                  |                            +                                             |   1        |

 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |

 __________________________________________________________________________________________________________________________________ 

  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
NTP Experiment-Test: 05186-04                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: SUBCHRON 90-DAY                                    CARISOPRODOL                                       Date: 04/06/98  
Route: GAVAGE                                                                                                     Time: 14:02:50  
                                                                                                                                    

 __________________________________________________________________________________________________________________________________ 
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |            |
                             DAY ON TEST   | 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|                                            |            |
                                           | 2| 2| 2| 2| 2| 2| 2| 2| 2| 7|                                            |      T (*) |

 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      A     |
    0 MG/KG                                | 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|                                            |      L     |
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                                            |            |

 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Bone Marrow                             |                            +                                             |   1        |

                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  |                            +                                             |   1        |

                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  |                            A                                             |            |

                                            __________________________________________________________________________|____________|
   Spleen                                  |                            +                                             |   1        |

                                            __________________________________________________________________________|____________|
   Thymus                                  |                            +                                             |   1        |
      Foreign Body                         |                            3                                             |      1  3.0|
      Inflammation, Suppurative            |                            4                                             |      1  4.0|

 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Mammary Gland                           |                            +                                             |   1        |

                                            __________________________________________________________________________|____________|
   Skin                                    |                            +                                             |   1        |

 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Bone                                    |                            +                                             |   1        |

 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Brain                                   |                            +                                             |   1        |

 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Lung                                    |                            +                                             |   1        |
      Mediastinum, Foreign Body            |                            4                                             |      1  4.0|
      Mediastinum, Inflammation,           |                                                                          |            |
          Suppurative                      |                            3                                             |      1  3.0|

                                            __________________________________________________________________________|____________|
   Nose                                    |                            +                                             |   1        |

                                            __________________________________________________________________________|____________|
   Trachea                                 |                            +                                             |   1        |

 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |

 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |

                                            __________________________________________________________________________|____________|
   Urinary Bladder                         |                            +                                             |   1        |

 __________________________________________________________________________________________________________________________________ 

  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
NTP Experiment-Test: 05186-04                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: SUBCHRON 90-DAY                                    CARISOPRODOL                                       Date: 04/06/98  
Route: GAVAGE                                                                                                     Time: 14:02:50  
                                                                                                                                    

 __________________________________________________________________________________________________________________________________ 
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |            |
                             DAY ON TEST   | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|                                            |            |
                                           | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|                                            |      T (*) |

 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      A     |
    600                                    | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6|                                            |      L     |
    MG/KG                                  | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                                            |            |

 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +                                             |  10        |
      Inflammation, Granulomatous          | 1        1     1                                                         |      3  1.0|

 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |

 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |

 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |

 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |

 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |

 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |

 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |

 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |

 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |

 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |

 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |

 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    

 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    

 __________________________________________________________________________________________________________________________________ 

  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
NTP Experiment-Test: 05186-04                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: SUBCHRON 90-DAY                                    CARISOPRODOL                                       Date: 04/06/98  
Route: GAVAGE                                                                                                     Time: 14:02:50  
                                                                                                                                    

 __________________________________________________________________________________________________________________________________ 
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |            |
                             DAY ON TEST   | 9| 9| 1| 9| 9| 9| 9| 0| 9| 9|                                            |            |
                                           | 2| 2| 4| 2| 2| 2| 2| 7| 2| 2|                                            |      T (*) |

 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      A     |
    1200                                   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 7|                                            |      L     |
    MG/KG                                  | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                                            |            |

 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Esophagus                               |       +              +                                                   |   2        |

                                            __________________________________________________________________________|____________|
   Gallbladder                             |       +              +                                                   |   2        |

                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  |       +              +                                                   |   2        |

                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 |       +              +                                                   |   2        |

                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  |       A              +                                                   |   1        |

                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               |       +              +                                                   |   2        |

                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                |       +              +                                                   |   2        |

                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  |       A              +                                                   |   1        |

                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +                                             |  10        |
      Inflammation, Granulomatous          | 1                 1        1                                             |      3  1.0|
      Centrilobular, Hypertrophy           | 1  1     1  1  1  1     1  1                                             |      8  1.0|

                                            __________________________________________________________________________|____________|
   Pancreas                                |       +              +                                                   |   2        |

                                            __________________________________________________________________________|____________|
   Salivary Glands                         |       +              +                                                   |   2        |

                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    |       +              +                                                   |   2        |

                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      |       +              +                                                   |   2        |

 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Blood Vessel                            |       M              +                                                   |   1        |

                                            __________________________________________________________________________|____________|
   Heart                                   |       +              +                                                   |   2        |
      Epicardium, Inflammation, Suppurative|                      2                                                   |      1  2.0|

 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Adrenal Cortex                          |       +              +                                                   |   2        |

                                            __________________________________________________________________________|____________|
   Adrenal Medulla                         |       +              +                                                   |   2        |

                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      |       +              +                                                   |   2        |

                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       |       +              +                                                   |   2        |

                                            __________________________________________________________________________|____________|
   Pituitary Gland                         |       +              +                                                   |   2        |

                                            __________________________________________________________________________|____________|
   Thyroid Gland                           |       +              +                                                   |   2        |

 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |

 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Clitoral Gland                          |       +              +                                                   |   2        |

                                            __________________________________________________________________________|____________|
   Ovary                                   |       +              +                                                   |   2        |

                                            __________________________________________________________________________|____________|
   Uterus                                  |       +              +                                                   |   2        |

 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Bone Marrow                             |       +              +                                                   |   2        |

 __________________________________________________________________________________________________________________________________ 

  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
NTP Experiment-Test: 05186-04                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: SUBCHRON 90-DAY                                    CARISOPRODOL                                       Date: 04/06/98  
Route: GAVAGE                                                                                                     Time: 14:02:50  
                                                                                                                                    

 __________________________________________________________________________________________________________________________________ 
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |            |
                             DAY ON TEST   | 9| 9| 1| 9| 9| 9| 9| 0| 9| 9|                                            |            |
                                           | 2| 2| 4| 2| 2| 2| 2| 7| 2| 2|                                            |      T (*) |

 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      A     |
    1200                                   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 7|                                            |      L     |
    MG/KG                                  | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                                            |            |

 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  |       +              +                                                   |   2        |

                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  |       +              +                                                   |   2        |

                                            __________________________________________________________________________|____________|
   Spleen                                  |       +              +                                                   |   2        |

                                            __________________________________________________________________________|____________|
   Thymus                                  |       +              +                                                   |   2        |
      Inflammation, Suppurative            |                      3                                                   |      1  3.0|
      Thymocyte, Autolysis                 |       1                                                                  |      1  1.0|
      Thymocyte, Necrosis                  |                      4                                                   |      1  4.0|

 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Mammary Gland                           |       +              +                                                   |   2        |

                                            __________________________________________________________________________|____________|
   Skin                                    |       +              +                                                   |   2        |

 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Bone                                    |       +              +                                                   |   2        |

 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Brain                                   |       +              +                                                   |   2        |

 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Lung                                    |       +              +                                                   |   2        |
      Congestion, Acute                    |       4                                                                  |      1  4.0|
      Mediastinum, Foreign Body            |                      4                                                   |      1  4.0|
      Mediastinum, Inflammation,           |                                                                          |            |
          Suppurative                      |       4              3                                                   |      2  3.5|

                                            __________________________________________________________________________|____________|
   Nose                                    |       +              +                                                   |   2        |

                                            __________________________________________________________________________|____________|
   Trachea                                 |       +              +                                                   |   2        |

 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |

 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Kidney                                  |       +              +                                                   |   2        |

                                            __________________________________________________________________________|____________|
   Urinary Bladder                         |       +              +                                                   |   2        |

 __________________________________________________________________________________________________________________________________ 

  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
NTP Experiment-Test: 05186-04                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: SUBCHRON 90-DAY                                    CARISOPRODOL                                       Date: 04/06/98  
Route: GAVAGE                                                                                                     Time: 14:02:50  
                                                                                                                                    

 __________________________________________________________________________________________________________________________________ 
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |            |
                             DAY ON TEST   | 9| 9| 9| 0| 9| 9| 9| 9| 9| 9|                                            |            |
                                           | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|                                            |      T (*) |

 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      A     |
    1600                                   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 8|                                            |      L     |
    MG/KG                                  | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                                            |            |

 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Esophagus                               |          +                                                               |   1        |

                                            __________________________________________________________________________|____________|
   Gallbladder                             |          A                                                               |            |

                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  |          +                                                               |   1        |

                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 |          +                                                               |   1        |

                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  |          +                                                               |   1        |

                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               |          +                                                               |   1        |

                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                |          +                                                               |   1        |

                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  |          +                                                               |   1        |

                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +                                             |  10        |
      Centrilobular, Hypertrophy           | 1  1  1     1  1  1  1  1  1                                             |      9  1.0|

                                            __________________________________________________________________________|____________|
   Pancreas                                |          +                                                               |   1        |

                                            __________________________________________________________________________|____________|
   Salivary Glands                         |          +                                                               |   1        |

                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    |          +                                                               |   1        |

                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      |          +                                                               |   1        |

 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Blood Vessel                            |          +                                                               |   1        |

                                            __________________________________________________________________________|____________|
   Heart                                   |          +                                                               |   1        |

 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Adrenal Cortex                          |          +                                                               |   1        |

                                            __________________________________________________________________________|____________|
   Adrenal Medulla                         |          +                                                               |   1        |

                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      |          +                                                               |   1        |

                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       |          +                                                               |   1        |

                                            __________________________________________________________________________|____________|
   Pituitary Gland                         |          +                                                               |   1        |

                                            __________________________________________________________________________|____________|
   Thyroid Gland                           |          +                                                               |   1        |

 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |

 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Clitoral Gland                          |          M                                                               |            |

                                            __________________________________________________________________________|____________|
   Ovary                                   |          +                                                               |   1        |

                                            __________________________________________________________________________|____________|
   Uterus                                  |          +                                                               |   1        |

 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Bone Marrow                             |          +                                                               |   1        |

                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  |          +                                                               |   1        |

                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  |          +                                                               |   1        |

 __________________________________________________________________________________________________________________________________ 

  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
NTP Experiment-Test: 05186-04                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: SUBCHRON 90-DAY                                    CARISOPRODOL                                       Date: 04/06/98  
Route: GAVAGE                                                                                                     Time: 14:02:50  
                                                                                                                                    

 __________________________________________________________________________________________________________________________________ 
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |            |
                             DAY ON TEST   | 9| 9| 9| 0| 9| 9| 9| 9| 9| 9|                                            |            |
                                           | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|                                            |      T (*) |

 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      A     |
    1600                                   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 8|                                            |      L     |
    MG/KG                                  | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                                            |            |

 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Spleen                                  |          +                                                               |   1        |

                                            __________________________________________________________________________|____________|
   Thymus                                  |          +                                                               |   1        |

 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Mammary Gland                           |          +                                                               |   1        |

                                            __________________________________________________________________________|____________|
   Skin                                    |          +                                                               |   1        |

 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Bone                                    |          +                                                               |   1        |

 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Brain                                   |          +                                                               |   1        |

 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Lung                                    |          +                                                               |   1        |

                                            __________________________________________________________________________|____________|
   Nose                                    |          +                                                               |   1        |

                                            __________________________________________________________________________|____________|
   Trachea                                 |          +                                                               |   1        |

 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |

 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |

                                            __________________________________________________________________________|____________|
   Urinary Bladder                         |          +                                                               |   1        |

 __________________________________________________________________________________________________________________________________ 

  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
NTP Experiment-Test: 05186-04                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: SUBCHRON 90-DAY                                    CARISOPRODOL                                       Date: 04/06/98  
Route: GAVAGE                                                                                                     Time: 14:02:50  
                                                                                                                                    

 __________________________________________________________________________________________________________________________________ 
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |            |
                             DAY ON TEST   | 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|                                            |            |
                                           | 2| 2| 2| 2| 2| 2| 2| 2| 2| 9|                                            |      T (*) |

 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      A     |
    0 MG/KG                                | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1|                                            |      L     |
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                                            |            |

 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Esophagus                               |                            +                                             |   1        |

                                            __________________________________________________________________________|____________|
   Gallbladder                             |                            +                                             |   1        |

                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  |                            +                                             |   1        |

                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 |                            +                                             |   1        |

                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  |                            +                                             |   1        |

                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               |                            +                                             |   1        |

                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                |                            +                                             |   1        |

                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  |                            +                                             |   1        |

                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +                                             |  10        |
      Hematopoietic Cell Proliferation     |                            2                                             |      1  2.0|
      Inflammation, Granulomatous          |                            2                                             |      1  2.0|

                                            __________________________________________________________________________|____________|
   Pancreas                                |                            +                                             |   1        |

                                            __________________________________________________________________________|____________|
   Salivary Glands                         |                            +                                             |   1        |
      Inflammation, Chronic Active         |                            2                                             |      1  2.0|

                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    |                            +                                             |   1        |

                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      |                            +                                             |   1        |

 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Blood Vessel                            |                            +                                             |   1        |

                                            __________________________________________________________________________|____________|
   Heart                                   |                            +                                             |   1        |
      Epicardium, Foreign Body             |                            1                                             |      1  1.0|
      Epicardium, Inflammation, Suppurative|                            2                                             |      1  2.0|

 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Adrenal Cortex                          |                            +                                             |   1        |

                                            __________________________________________________________________________|____________|
   Adrenal Medulla                         |                            +                                             |   1        |

                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      |                            +                                             |   1        |

                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       |                            M                                             |            |

                                            __________________________________________________________________________|____________|
   Pituitary Gland                         |                            +                                             |   1        |

                                            __________________________________________________________________________|____________|
   Thyroid Gland                           |                            +                                             |   1        |

 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |

 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Epididymis                              |                            +                                             |   1        |

                                            __________________________________________________________________________|____________|
   Preputial Gland                         |                            +                                             |   1        |

                                            __________________________________________________________________________|____________|
   Prostate                                |                            +                                             |   1        |

                                            __________________________________________________________________________|____________|
   Seminal Vesicle                         |                            +                                             |   1        |

 __________________________________________________________________________________________________________________________________ 

  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
NTP Experiment-Test: 05186-04                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: SUBCHRON 90-DAY                                    CARISOPRODOL                                       Date: 04/06/98  
Route: GAVAGE                                                                                                     Time: 14:02:50  
                                                                                                                                    

 __________________________________________________________________________________________________________________________________ 
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |            |
                             DAY ON TEST   | 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|                                            |            |
                                           | 2| 2| 2| 2| 2| 2| 2| 2| 2| 9|                                            |      T (*) |

 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      A     |
    0 MG/KG                                | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1|                                            |      L     |
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                                            |            |

 __________________________________________________________________________________________________________________________________ 
 GENITAL SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Testes                                  |                            +                                             |   1        |

 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Bone Marrow                             |                            +                                             |   1        |

                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  |                            +                                             |   1        |

                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  |                            +                                             |   1        |

                                            __________________________________________________________________________|____________|
   Spleen                                  |                            +                                             |   1        |
      Hematopoietic Cell Proliferation     |                            4                                             |      1  4.0|

                                            __________________________________________________________________________|____________|
   Thymus                                  |                            +                                             |   1        |
      Inflammation, Granulomatous          |                            3                                             |      1  3.0|

 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Mammary Gland                           |                            M                                             |            |

                                            __________________________________________________________________________|____________|
   Skin                                    |                            +                                             |   1        |

 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Bone                                    |                            +                                             |   1        |

 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Brain                                   |                            +                                             |   1        |

 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Lung                                    |                            +                                             |   1        |
      Inflammation, Chronic Active         |                            3                                             |      1  3.0|
      Mediastinum, Foreign Body            |                            1                                             |      1  1.0|

                                            __________________________________________________________________________|____________|
   Nose                                    |                            +                                             |   1        |

                                            __________________________________________________________________________|____________|
   Trachea                                 |                            +                                             |   1        |

 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |

 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |
      Inflammation, Chronic Active         |                            1                                             |      1  1.0|
      Renal Tubule, Regeneration           |          1  1                                                            |      2  1.0|

                                            __________________________________________________________________________|____________|
   Urinary Bladder                         |                            +                                             |   1        |

 __________________________________________________________________________________________________________________________________ 

  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
NTP Experiment-Test: 05186-04                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: SUBCHRON 90-DAY                                    CARISOPRODOL                                       Date: 04/06/98  
Route: GAVAGE                                                                                                     Time: 14:02:50  
                                                                                                                                    

 __________________________________________________________________________________________________________________________________ 
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |            |
                             DAY ON TEST   | 9| 9| 9| 0| 9| 9| 9| 9| 9| 9|                                            |            |
                                           | 2| 2| 2| 6| 2| 2| 2| 2| 2| 2|                                            |      T (*) |

 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      A     |
    600                                    | 1| 1| 1| 1| 1| 1| 1| 1| 1| 2|                                            |      L     |
    MG/KG                                  | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                                            |            |

 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Esophagus                               |          +                                                               |   1        |
      Muscularis, Inflammation, Chronic    |                                                                          |            |
          Active                           |          2                                                               |      1  2.0|

                                            __________________________________________________________________________|____________|
   Gallbladder                             |          +                                                               |   1        |

                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  |          +                                                               |   1        |

                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 |          +                                                               |   1        |

                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  |          +                                                               |   1        |

                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               |          +                                                               |   1        |

                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                |          +                                                               |   1        |

                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  |          +                                                               |   1        |

                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +                                             |  10        |
      Centrilobular, Hypertrophy           | 1  1  1     1  1  1  1  1  1                                             |      9  1.0|

                                            __________________________________________________________________________|____________|
   Pancreas                                |          +                                                               |   1        |

                                            __________________________________________________________________________|____________|
   Salivary Glands                         |          +                                                               |   1        |

                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    |          +                                                               |   1        |

                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      |          +                                                               |   1        |

 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Blood Vessel                            |          +                                                               |   1        |

                                            __________________________________________________________________________|____________|
   Heart                                   |          +                                                               |   1        |

 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Adrenal Cortex                          |          +                                                               |   1        |

                                            __________________________________________________________________________|____________|
   Adrenal Medulla                         |          +                                                               |   1        |

                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      |          +                                                               |   1        |

                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       |          M                                                               |            |

                                            __________________________________________________________________________|____________|
   Pituitary Gland                         |          +                                                               |   1        |

                                            __________________________________________________________________________|____________|
   Thyroid Gland                           |          +                                                               |   1        |

 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |

 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Epididymis                              |          +                                                               |   1        |

                                            __________________________________________________________________________|____________|
   Preputial Gland                         |          +                                                               |   1        |

                                            __________________________________________________________________________|____________|
   Prostate                                |          +                                                               |   1        |

                                            __________________________________________________________________________|____________|
   Seminal Vesicle                         |          +                                                               |   1        |

                                            __________________________________________________________________________|____________|
   Testes                                  |          +                                                               |   1        |

 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |

 __________________________________________________________________________________________________________________________________ 

  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
NTP Experiment-Test: 05186-04                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: SUBCHRON 90-DAY                                    CARISOPRODOL                                       Date: 04/06/98  
Route: GAVAGE                                                                                                     Time: 14:02:50  
                                                                                                                                    

 __________________________________________________________________________________________________________________________________ 
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |            |
                             DAY ON TEST   | 9| 9| 9| 0| 9| 9| 9| 9| 9| 9|                                            |            |
                                           | 2| 2| 2| 6| 2| 2| 2| 2| 2| 2|                                            |      T (*) |

 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      A     |
    600                                    | 1| 1| 1| 1| 1| 1| 1| 1| 1| 2|                                            |      L     |
    MG/KG                                  | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                                            |            |

 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Bone Marrow                             |          +                                                               |   1        |

                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  |          +                                                               |   1        |

                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  |          +                                                               |   1        |

                                            __________________________________________________________________________|____________|
   Spleen                                  |          +                                                               |   1        |

                                            __________________________________________________________________________|____________|
   Thymus                                  |          +                                                               |   1        |

 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Mammary Gland                           |          M                                                               |            |

                                            __________________________________________________________________________|____________|
   Skin                                    |          +                                                               |   1        |

 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Bone                                    |          +                                                               |   1        |

 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Brain                                   |          +                                                               |   1        |

 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Lung                                    |          +                                                               |   1        |

                                            __________________________________________________________________________|____________|
   Nose                                    |          +                                                               |   1        |

                                            __________________________________________________________________________|____________|
   Trachea                                 |          +                                                               |   1        |

 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |

 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Kidney                                  |          +                                                               |   1        |

                                            __________________________________________________________________________|____________|
   Urinary Bladder                         |          +                                                               |   1        |

 __________________________________________________________________________________________________________________________________ 

  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
NTP Experiment-Test: 05186-04                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: SUBCHRON 90-DAY                                    CARISOPRODOL                                       Date: 04/06/98  
Route: GAVAGE                                                                                                     Time: 14:02:50  
                                                                                                                                    

 __________________________________________________________________________________________________________________________________ 
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |            |
                             DAY ON TEST   | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|                                            |            |
                                           | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|                                            |      T (*) |

 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      A     |
    1200                                   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3|                                            |      L     |
    MG/KG                                  | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                                            |            |

 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +                                             |  10        |
      Centrilobular, Hypertrophy           | 2  2  2  2  2  2  2  2  2  2                                             |     10  2.0|

 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |

 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |

 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |

 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |

 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |

 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |

 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |

 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |

 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |

 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |

 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |

 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    

 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    

 __________________________________________________________________________________________________________________________________ 

  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
NTP Experiment-Test: 05186-04                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: SUBCHRON 90-DAY                                    CARISOPRODOL                                       Date: 04/06/98  
Route: GAVAGE                                                                                                     Time: 14:02:50  
                                                                                                                                    

 __________________________________________________________________________________________________________________________________ 
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |            |
                             DAY ON TEST   | 9| 9| 9| 9| 9| 9| 1| 9| 0| 1|                                            |            |
                                           | 2| 2| 2| 2| 2| 2| 3| 2| 2| 3|                                            |      T (*) |

 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      A     |
    1600                                   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 4|                                            |      L     |
    MG/KG                                  | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                                            |            |

 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Esophagus                               |                   +     +  +                                             |   3        |

                                            __________________________________________________________________________|____________|
   Gallbladder                             |                   +     +  +                                             |   3        |

                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  |                   +     +  +                                             |   3        |

                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 |                   +     +  +                                             |   3        |

                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  |                   +     +  +                                             |   3        |

                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               |                   +     +  +                                             |   3        |

                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                |                   +     +  +                                             |   3        |

                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  |                   +     +  +                                             |   3        |

                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +                                             |  10        |
      Centrilobular, Hypertrophy           | 2  2  2  2  2  2     2                                                   |      7  2.0|

                                            __________________________________________________________________________|____________|
   Pancreas                                |                   +     +  +                                             |   3        |

                                            __________________________________________________________________________|____________|
   Salivary Glands                         |                   +     +  +                                             |   3        |

                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    |                   +     +  +                                             |   3        |

                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      |                   +     +  +                                             |   3        |

 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Blood Vessel                            |                   +     +  +                                             |   3        |

                                            __________________________________________________________________________|____________|
   Heart                                   |                   +     +  +                                             |   3        |

 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Adrenal Cortex                          |                   +     +  +                                             |   3        |

                                            __________________________________________________________________________|____________|
   Adrenal Medulla                         |                   +     +  +                                             |   3        |

                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      |                   +     +  +                                             |   3        |

                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       |                   M     +  M                                             |   1        |

                                            __________________________________________________________________________|____________|
   Pituitary Gland                         |                   +     +  +                                             |   3        |

                                            __________________________________________________________________________|____________|
   Thyroid Gland                           |                   +     +  +                                             |   3        |

 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |

 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Epididymis                              |                   +     +  +                                             |   3        |

                                            __________________________________________________________________________|____________|
   Preputial Gland                         |                   +     +  +                                             |   3        |

                                            __________________________________________________________________________|____________|
   Prostate                                |                   +     +  +                                             |   3        |

                                            __________________________________________________________________________|____________|
   Seminal Vesicle                         |                   +     +  +                                             |   3        |

                                            __________________________________________________________________________|____________|
   Testes                                  |                   +     +  +                                             |   3        |

 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Bone Marrow                             |                   +     +  +                                             |   3        |

 __________________________________________________________________________________________________________________________________ 

  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
NTP Experiment-Test: 05186-04                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: SUBCHRON 90-DAY                                    CARISOPRODOL                                       Date: 04/06/98  
Route: GAVAGE                                                                                                     Time: 14:02:50  
                                                                                                                                    

 __________________________________________________________________________________________________________________________________ 
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |            |
                             DAY ON TEST   | 9| 9| 9| 9| 9| 9| 1| 9| 0| 1|                                            |            |
                                           | 2| 2| 2| 2| 2| 2| 3| 2| 2| 3|                                            |      T (*) |

 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      A     |
    1600                                   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 4|                                            |      L     |
    MG/KG                                  | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                                            |            |

 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  |                   +     +  +                                             |   3        |

                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  |                   +     +  +                                             |   3        |

                                            __________________________________________________________________________|____________|
   Spleen                                  |                   +     +  +                                             |   3        |

                                            __________________________________________________________________________|____________|
   Thymus                                  |                   +     +  +                                             |   3        |
      Thymocyte, Autolysis                 |                   2     2  2                                             |      3  2.0|

 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Mammary Gland                           |                   M     M  M                                             |            |

                                            __________________________________________________________________________|____________|
   Skin                                    |                   +     +  +                                             |   3        |

 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Bone                                    |                   +     +  +                                             |   3        |

 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Brain                                   |                   +     +  +                                             |   3        |

 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Lung                                    |                   +     +  +                                             |   3        |
      Inflammation, Suppurative            |                            2                                             |      1  2.0|
      Mediastinum, Foreign Body            |                   3                                                      |      1  3.0|
      Mediastinum, Inflammation,           |                                                                          |            |
          Suppurative                      |                   2        2                                             |      2  2.0|

                                            __________________________________________________________________________|____________|
   Nose                                    |                   +     +  +                                             |   3        |

                                            __________________________________________________________________________|____________|
   Trachea                                 |                   +     +  +                                             |   3        |

 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |

 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |
      Renal Tubule, Regeneration           | 1     1                                                                  |      2  1.0|

                                            __________________________________________________________________________|____________|
   Urinary Bladder                         |                   +     +  +                                             |   3        |

 __________________________________________________________________________________________________________________________________ 

  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                             ------------------------------------------------------------                                           
                             ----------              END OF REPORT             ----------                                           
                             ------------------------------------------------------------