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TDMS Study 05187-06 Pathology Tables

NTP Experiment-Test: 05187-06         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                           METHYLEUGENOL                                       Date: 07/20/98
Route: GAVAGE                                                                                                     Time: 10:15:51

                                                           CORE STUDY




       Facility:  Battelle Columbus Laboratory

       Chemical CAS #:  93-15-2

       Lock Date:  06/12/96

       Cage Range:  All

       Reasons For Removal:    All

       Removal Date Range:     All

       Treatment Groups:       Include All


































a  Number of animals examined microscopically at site and number of animals with lesion

                                                              Page   1


NTP Experiment-Test: 05187-06         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                           METHYLEUGENOL                                       Date: 07/20/98  
Route: GAVAGE                                                                                                     Time: 10:15:51  
____________________________________________________________________________________________________________________________________

         B6C3F1 MICE FEMALE                        0 MG/KG      37 MG/KG     75 MG/KG     150                                       
                                                                                          MG/KG                                     
____________________________________________________________________________________________________________________________________

DISPOSITION SUMMARY                                                                                                                 


  Animals Initially In Study                          50           50           50           50                                     
  Early Deaths                                                                                                                      
    Moribund Sacrifice                                 5            7            8           13                                     
    Natural Death                                     14           24           23           35                                     
    Dosing Accident                                                 1            1                                                  
  Survivors                                                                                                                         
    Natural Death                                                                2                                                  
    Terminal Sacrifice                                31           18           16            2                                     

  Animals Examined Microscopically                    50           50           50           50                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Gallbladder                                        (38)         (28)         (30)         (24)                                   
      Infiltration Cellular, Lymphocyte                             1 (4%)                                                          
   Intestine Small, Duodenum                          (46)         (49)         (46)         (43)                                   
      Inflammation, Chronic Active                                  1 (2%)                                                          
      Parasite Metazoan                                             1 (2%)                                                          
      Ulcer                                                                      1 (2%)                                             
      Epithelium, Necrosis                                          1 (2%)                                                          
   Intestine Small, Jejunum                           (46)         (46)         (40)         (40)                                   
      Inflammation, Suppurative                                     1 (2%)                                                          
      Ulcer                                                         1 (2%)                                                          
   Liver                                              (50)         (50)         (49)         (50)                                   
      Atrophy                                                                    1 (2%)                                             
      Basophilic Focus                                 5 (10%)      2 (4%)                    3 (6%)                                
      Clear Cell Focus                                 1 (2%)       2 (4%)                    1 (2%)                                
      Cyst                                             1 (2%)                                                                       
      Eosinophilic Focus                               5 (10%)      9 (18%)      4 (8%)       9 (18%)                               
      Fibrosis                                         1 (2%)       2 (4%)       3 (6%)                                             
      Hematopoietic Cell Proliferation                 4 (8%)      14 (28%)     23 (47%)     24 (48%)                               
      Infiltration Cellular, Lymphocyte               23 (46%)     18 (36%)     21 (43%)     19 (38%)                               
      Inflammation, Chronic Active                    24 (48%)     25 (50%)     16 (33%)     10 (20%)                               
      Inflammation, Suppurative                                                               1 (2%)                                
      Mineralization                                   1 (2%)       2 (4%)                                                          
      Mixed Cell Focus                                 7 (14%)      3 (6%)                                                          
      Pigmentation, Hemosiderin                                    11 (22%)     24 (49%)     19 (38%)                               
      Tension Lipidosis                                2 (4%)                                                                       
      Bile Duct, Cyst                                               1 (2%)       6 (12%)      3 (6%)                                
      Bile Duct, Cyst, Multiple                        1 (2%)                                                                       
      Bile Duct, Hyperplasia                           1 (2%)       1 (2%)      11 (22%)      9 (18%)                               
      Hepatocyte, Atypia Cellular                                   1 (2%)                                                          
      Hepatocyte, Hyperplasia, Adenomatous                                                    1 (2%)                                
      Hepatocyte, Necrosis                             5 (10%)      9 (18%)     16 (33%)     17 (34%)                               
      Hepatocyte, Vacuolization Cytoplasmic           20 (40%)     14 (28%)     11 (22%)     12 (24%)                               

a  Number of animals examined microscopically at site and number of animals with lesion                                             
NTP Experiment-Test: 05187-06         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                           METHYLEUGENOL                                       Date: 07/20/98  
Route: GAVAGE                                                                                                     Time: 10:15:51  
____________________________________________________________________________________________________________________________________

         B6C3F1 MICE FEMALE                        0 MG/KG      37 MG/KG     75 MG/KG     150                                       
                                                                                          MG/KG                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ALIMENTARY SYSTEM - CONT                                                                                                            
      Hepatocyte, Centrilobular, Atrophy                                                      1 (2%)                                
      Oval Cell, Hyperplasia                                       46 (92%)     36 (73%)     38 (76%)                               
      Portal, Hypertrophy                                          10 (20%)      7 (14%)     23 (46%)                               
   Mesentery                                          (13)         (7)          (3)          (3)                                    
      Inflammation, Chronic Active                     1 (8%)                                                                       
      Inflammation, Suppurative                                                               1 (33%)                               
      Artery, Inflammation, Chronic Active                          1 (14%)                                                         
      Artery, Necrosis, Fibrinoid                                   1 (14%)                                                         
      Fat, Necrosis                                    6 (46%)      3 (43%)      1 (33%)      1 (33%)                               
   Pancreas                                           (49)         (50)         (46)         (46)                                   
      Infiltration Cellular, Lymphocyte               10 (20%)     15 (30%)     13 (28%)      2 (4%)                                
      Acinus, Atrophy                                               1 (2%)                                                          
      Artery, Inflammation, Chronic Active                          1 (2%)                                                          
      Artery, Necrosis, Fibrinoid                                   1 (2%)                                                          
   Salivary Glands                                    (50)         (45)         (44)         (42)                                   
      Infiltration Cellular, Lymphocyte               33 (66%)     29 (64%)     27 (61%)     18 (43%)                               
   Stomach, Forestomach                               (50)         (50)         (48)         (46)                                   
      Diverticulum                                                               1 (2%)                                             
      Hyperkeratosis                                   1 (2%)       3 (6%)                    3 (7%)                                
      Inflammation, Chronic Active                                  2 (4%)       1 (2%)                                             
      Epithelium, Hyperplasia, Squamous                1 (2%)       3 (6%)       2 (4%)       1 (2%)                                
      Epithelium, Ulcer                                             2 (4%)                                                          
   Stomach, Glandular                                 (45)         (49)         (46)         (45)                                   
      Atrophy                                                                   10 (22%)     10 (22%)                               
      Ectasia                                         14 (31%)     33 (67%)     31 (67%)     38 (84%)                               
      Hyperplasia                                                   1 (2%)       5 (11%)      2 (4%)                                
      Hyperplasia, Atypical                                                                   1 (2%)                                
      Inflammation, Chronic Active                    17 (38%)     21 (43%)     12 (26%)     14 (31%)                               
      Mineralization                                   2 (4%)       1 (2%)       2 (4%)       3 (7%)                                
      Necrosis                                                      1 (2%)       3 (7%)       2 (4%)                                
      Neuroendocrine Cell, Hyperplasia                              1 (2%)                                                          
   Tooth                                              (2)          (1)                                                              
      Inflammation, Chronic Active                     1 (50%)      1 (100%)                                                        
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Blood Vessel                                       (50)         (50)         (49)         (47)                                   
      Inflammation, Chronic Active                                  1 (2%)                                                          
      Mineralization                                   1 (2%)                                                                       
   Heart                                              (50)         (50)         (48)         (44)                                   
      Inflammation, Chronic Active                     1 (2%)                                                                       
      Mineralization                                   2 (4%)       1 (2%)       1 (2%)                                             
      Artery, Inflammation, Chronic Active                          1 (2%)                                                          
      Atrium, Thrombosis                               1 (2%)       3 (6%)       6 (13%)      9 (20%)                               
      Valve, Inflammation, Suppurative                                                        1 (2%)                                
      Valve, Thrombosis                                                                       1 (2%)                                

a  Number of animals examined microscopically at site and number of animals with lesion                                             
NTP Experiment-Test: 05187-06         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                           METHYLEUGENOL                                       Date: 07/20/98  
Route: GAVAGE                                                                                                     Time: 10:15:51  
____________________________________________________________________________________________________________________________________

         B6C3F1 MICE FEMALE                        0 MG/KG      37 MG/KG     75 MG/KG     150                                       
                                                                                          MG/KG                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Cortex                                     (50)         (50)         (50)         (49)                                   
      Degeneration, Fatty                              1 (2%)                                 1 (2%)                                
      Hematopoietic Cell Proliferation                 2 (4%)       8 (16%)     17 (34%)     14 (29%)                               
      Pigmentation, Hemosiderin                                                               1 (2%)                                
      Subcapsular, Hyperplasia                        47 (94%)     48 (96%)     49 (98%)     48 (98%)                               
   Adrenal Medulla                                    (50)         (50)         (50)         (49)                                   
      Hyperplasia                                                   1 (2%)       7 (14%)      5 (10%)                               
   Islets, Pancreatic                                 (49)         (50)         (46)         (47)                                   
      Hyperplasia                                      8 (16%)      3 (6%)       1 (2%)       2 (4%)                                
   Parathyroid Gland                                  (36)         (40)         (38)         (36)                                   
      Cyst                                             1 (3%)       1 (3%)                                                          
   Pituitary Gland                                    (48)         (44)         (44)         (40)                                   
      Pars Distalis, Angiectasis                       7 (15%)                                                                      
      Pars Distalis, Cyst                              1 (2%)                    1 (2%)       1 (3%)                                
      Pars Distalis, Hyperplasia                       6 (13%)      8 (18%)      3 (7%)       3 (8%)                                
   Thyroid Gland                                      (50)         (46)         (46)         (42)                                   
      Infiltration Cellular, Lymphocyte                             1 (2%)                                                          
      Inflammation, Chronic Active                                  1 (2%)                                                          
      Follicle, Cyst                                                1 (2%)       1 (2%)                                             
      Follicular Cell, Hyperplasia                     8 (16%)     10 (22%)      7 (15%)      5 (12%)                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Clitoral Gland                                     (47)         (47)         (46)         (44)                                   
      Cyst                                                          2 (4%)                                                          
      Infiltration Cellular, Lymphocyte                             1 (2%)                                                          
   Ovary                                              (50)         (49)         (48)         (41)                                   
      Angiectasis                                      1 (2%)       1 (2%)                                                          
      Cyst                                            12 (24%)      7 (14%)      7 (15%)      4 (10%)                               
      Infiltration Cellular, Lymphocyte                             1 (2%)       1 (2%)                                             
      Mineralization                                   1 (2%)                                                                       
      Pigmentation, Hemosiderin                        1 (2%)                                                                       
      Thrombosis                                                                              2 (5%)                                
   Uterus                                             (50)         (50)         (49)         (47)                                   
      Hemorrhage                                                                              1 (2%)                                
      Hydrometra                                      25 (50%)     24 (48%)     15 (31%)      5 (11%)                               
      Hyperplasia, Cystic                             19 (38%)     10 (20%)                   2 (4%)                                
      Infiltration Cellular, Lymphocyte                1 (2%)                    1 (2%)                                             
      Inflammation, Chronic Active                                  1 (2%)                                                          

a  Number of animals examined microscopically at site and number of animals with lesion                                             
NTP Experiment-Test: 05187-06         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                           METHYLEUGENOL                                       Date: 07/20/98  
Route: GAVAGE                                                                                                     Time: 10:15:51  
____________________________________________________________________________________________________________________________________

         B6C3F1 MICE FEMALE                        0 MG/KG      37 MG/KG     75 MG/KG     150                                       
                                                                                          MG/KG                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (50)         (50)         (48)         (50)                                   
      Hyperplasia                                     18 (36%)     47 (94%)     46 (96%)     50 (100%)                              
      Myelofibrosis                                   10 (20%)      7 (14%)      3 (6%)       3 (6%)                                
   Lymph Node                                         (13)         (7)          (8)          (4)                                    
      Inguinal, Infiltration Cellular, Mast Cell                                              1 (25%)                               
      Lumbar, Ectasia                                               1 (14%)                                                         
      Mediastinal, Hyperplasia, Lymphoid               2 (15%)                                                                      
      Mediastinal, Necrosis                                         1 (14%)                                                         
      Pancreatic, Hyperplasia                                       1 (14%)                                                         
      Renal, Ectasia                                   1 (8%)                                                                       
   Lymph Node, Mandibular                             (49)         (43)         (41)         (32)                                   
      Hyperplasia, Lymphoid                            1 (2%)                                                                       
      Hyperplasia, Plasma Cell                         1 (2%)                                                                       
   Lymph Node, Mesenteric                             (47)         (48)         (43)         (36)                                   
      Angiectasis                                                   1 (2%)       1 (2%)                                             
      Ectasia                                          1 (2%)       2 (4%)       1 (2%)                                             
      Hematopoietic Cell Proliferation                              1 (2%)       1 (2%)                                             
      Infiltration Cellular, Lymphocyte                1 (2%)                                                                       
      Necrosis                                         1 (2%)       1 (2%)                                                          
   Spleen                                             (50)         (50)         (46)         (46)                                   
      Atrophy                                                                                 1 (2%)                                
      Fibrosis                                                                   1 (2%)                                             
      Necrosis                                         1 (2%)                                                                       
      Pigmentation, Hemosiderin                        1 (2%)                                                                       
      Lymphoid Follicle, Depletion Cellular                         1 (2%)                    2 (4%)                                
      Lymphoid Follicle, Hyperplasia, Lymphoid         8 (16%)      3 (6%)       2 (4%)                                             
      Lymphoid Follicle, Necrosis                                   2 (4%)       4 (9%)       1 (2%)                                
      Red Pulp, Hematopoietic Cell Proliferation      29 (58%)     40 (80%)     45 (98%)     44 (96%)                               
   Thymus                                             (45)         (43)         (40)         (33)                                   
      Cyst                                            14 (31%)      9 (21%)      5 (13%)      7 (21%)                               
      Ectopic Parathyroid Gland                                                               1 (3%)                                
      Thymocyte, Necrosis                                           2 (5%)       3 (8%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Mammary Gland                                      (50)         (48)         (50)         (37)                                   
      Hyperplasia, Cystic                              1 (2%)       1 (2%)                                                          
   Skin                                               (50)         (50)         (50)         (49)                                   
      Subcutaneous Tissue, Infiltration Cellular,                                                                                   
           Lymphocyte                                  1 (2%)                    2 (4%)       2 (4%)                                
      Subcutaneous Tissue, Inflammation, Chronic                                                                                    
          Active                                       1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    

a  Number of animals examined microscopically at site and number of animals with lesion                                             
NTP Experiment-Test: 05187-06         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                           METHYLEUGENOL                                       Date: 07/20/98  
Route: GAVAGE                                                                                                     Time: 10:15:51  
____________________________________________________________________________________________________________________________________

         B6C3F1 MICE FEMALE                        0 MG/KG      37 MG/KG     75 MG/KG     150                                       
                                                                                          MG/KG                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Skeletal Muscle                                    (2)          (8)          (3)          (3)                                    
      Infiltration Cellular, Lymphocyte                             5 (63%)      1 (33%)      2 (67%)                               
      Artery, Inflammation, Chronic Active                          1 (13%)                                                         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Peripheral Nerve                                                (1)                                                              
      Demyelination                                                 1 (100%)                                                        
   Spinal Cord                                                     (1)                                                              
      Demyelination                                                 1 (100%)                                                        
      Artery, Inflammation, Chronic Active                          1 (100%)                                                        
      Artery, Necrosis, Fibrinoid                                   1 (100%)                                                        
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (50)         (50)         (48)         (45)                                   
      Infiltration Cellular, Lymphocyte                1 (2%)       1 (2%)                    1 (2%)                                
      Inflammation, Chronic Active                                  1 (2%)                    2 (4%)                                
      Inflammation, Suppurative                                                               1 (2%)                                
      Metaplasia, Osseous                                                                     1 (2%)                                
      Alveolar Epithelium, Hyperplasia                 2 (4%)       1 (2%)                                                          
      Alveolus, Infiltration Cellular, Histiocyte      1 (2%)       1 (2%)       2 (4%)       4 (9%)                                
      Bronchiole, Exudate, Organized                                             1 (2%)                                             
      Mediastinum, Inflammation, Chronic Active                                  1 (2%)                                             
      Mediastinum, Necrosis                                                      1 (2%)                                             
   Nose                                               (50)         (50)         (49)         (47)                                   
      Inflammation, Suppurative                        8 (16%)     11 (22%)     13 (27%)     11 (23%)                               
      Nasolacrimal Duct, Inflammation, Suppurative     4 (8%)      15 (30%)     11 (22%)     12 (26%)                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Eye                                                (2)                       (1)                                                 
      Atrophy                                                                    1 (100%)                                           
      Hemorrhage                                       1 (50%)                                                                      
      Inflammation, Suppurative                        1 (50%)                                                                      
      Cornea, Inflammation, Chronic Active             1 (50%)                                                                      
   Harderian Gland                                    (5)          (2)          (2)                                                 
      Inflammation, Suppurative                                                  1 (50%)                                            
____________________________________________________________________________________________________________________________________
                                                                                                                                    

a  Number of animals examined microscopically at site and number of animals with lesion                                             
NTP Experiment-Test: 05187-06         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                           METHYLEUGENOL                                       Date: 07/20/98  
Route: GAVAGE                                                                                                     Time: 10:15:51  
____________________________________________________________________________________________________________________________________

         B6C3F1 MICE FEMALE                        0 MG/KG      37 MG/KG     75 MG/KG     150                                       
                                                                                          MG/KG                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (50)         (50)         (50)         (49)                                   
      Accumulation, Hyaline Droplet                    1 (2%)       3 (6%)                                                          
      Hydronephrosis                                                                          2 (4%)                                
      Infiltration Cellular, Lymphocyte               28 (56%)     29 (58%)     29 (58%)     23 (47%)                               
      Metaplasia, Osseous                              2 (4%)       1 (2%)                    1 (2%)                                
      Mineralization                                   1 (2%)       3 (6%)       2 (4%)       2 (4%)                                
      Necrosis                                                                   1 (2%)                                             
      Nephropathy                                     10 (20%)     13 (26%)      9 (18%)     10 (20%)                               
      Artery, Inflammation, Chronic Active                          2 (4%)                                                          
      Cortex, Cyst                                                  1 (2%)                    2 (4%)                                
      Glomerulus, Amyloid Deposition                                                          1 (2%)                                
      Renal Tubule, Hyperplasia                                                  1 (2%)                                             
      Renal Tubule, Pigmentation, Hemosiderin                                    2 (4%)       2 (4%)                                
   Urinary Bladder                                    (50)         (49)         (47)         (46)                                   
      Infiltration Cellular, Lymphocyte               20 (40%)     29 (59%)     27 (57%)     25 (54%)                               
      Inflammation, Chronic Active                     2 (4%)                                                                       
                                                                                                                                    

a  Number of animals examined microscopically at site and number of animals with lesion                                             
NTP Experiment-Test: 05187-06         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                           METHYLEUGENOL                                       Date: 07/20/98  
Route: GAVAGE                                                                                                     Time: 10:15:51  
____________________________________________________________________________________________________________________________________

         B6C3F1 MICE MALE                          0 MG/KG      37 MG/KG     75 MG/KG     150                                       
                                                                                          MG/KG                                     
____________________________________________________________________________________________________________________________________

DISPOSITION SUMMARY                                                                                                                 


  Animals Initially In Study                          50           50           50           50                                     
  Early Deaths                                                                                                                      
    Moribund Sacrifice                                 5            6            5            9                                     
    Natural Death                                      6            8            7            4                                     
    Accidently Killed                                                            1            1                                     
    Dosing Accident                                                                           1                                     
  Survivors                                                                                                                         
    Terminal Sacrifice                                38           36           37           35                                     
  Missing                                              1                                                                            

  Animals Examined Microscopically                    49           50           50           50                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Intestine Small, Duodenum                          (47)         (47)         (48)         (50)                                   
      Inflammation, Chronic Active                                  1 (2%)                                                          
      Ulcer                                                         1 (2%)                                                          
   Intestine Small, Jejunum                           (49)         (49)         (48)         (48)                                   
      Inflammation, Chronic Active                     1 (2%)                                                                       
      Peyer's Patch, Hyperplasia, Lymphoid             1 (2%)       1 (2%)                                                          
      Peyer's Patch, Inflammation, Suppurative                                                1 (2%)                                
   Liver                                              (49)         (50)         (50)         (50)                                   
      Angiectasis                                      1 (2%)                                                                       
      Atrophy                                                                                 1 (2%)                                
      Basophilic Focus                                 5 (10%)      3 (6%)       1 (2%)       3 (6%)                                
      Clear Cell Focus                                16 (33%)      8 (16%)      2 (4%)       6 (12%)                               
      Eosinophilic Focus                              10 (20%)     20 (40%)     25 (50%)     19 (38%)                               
      Fibrosis                                         1 (2%)       4 (8%)       1 (2%)                                             
      Hematopoietic Cell Proliferation                 3 (6%)       9 (18%)      7 (14%)      9 (18%)                               
      Infiltration Cellular, Lymphocyte                6 (12%)      5 (10%)     12 (24%)     10 (20%)                               
      Inflammation, Chronic Active                    19 (39%)     21 (42%)     28 (56%)     28 (56%)                               
      Mineralization                                                3 (6%)       1 (2%)                                             
      Mixed Cell Focus                                 9 (18%)     13 (26%)      9 (18%)      7 (14%)                               
      Pigmentation, Hemosiderin                        3 (6%)       5 (10%)      6 (12%)      5 (10%)                               
      Tension Lipidosis                                             1 (2%)                                                          
      Bile Duct, Cyst                                               1 (2%)       1 (2%)                                             
      Bile Duct, Hyperplasia                                        1 (2%)                    1 (2%)                                
      Hepatocyte, Necrosis                             8 (16%)     14 (28%)      8 (16%)     10 (20%)                               
      Hepatocyte, Vacuolization Cytoplasmic            7 (14%)      7 (14%)      2 (4%)      13 (26%)                               
      Hepatocyte, Centrilobular, Atrophy                                         1 (2%)                                             
      Hepatocyte, Centrilobular, Necrosis                                                     2 (4%)                                
      Oval Cell, Hyperplasia                                        8 (16%)     27 (54%)     46 (92%)                               
      Portal, Hypertrophy                                           1 (2%)       7 (14%)     46 (92%)                               
   Mesentery                                          (1)          (2)          (1)          (1)                                    
      Thrombosis                                       1 (100%)                                                                     

a  Number of animals examined microscopically at site and number of animals with lesion                                             
NTP Experiment-Test: 05187-06         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                           METHYLEUGENOL                                       Date: 07/20/98  
Route: GAVAGE                                                                                                     Time: 10:15:51  
____________________________________________________________________________________________________________________________________

         B6C3F1 MICE MALE                          0 MG/KG      37 MG/KG     75 MG/KG     150                                       
                                                                                          MG/KG                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ALIMENTARY SYSTEM - CONT                                                                                                            
      Fat, Necrosis                                                              1 (100%)                                           
   Pancreas                                           (49)         (49)         (50)         (50)                                   
      Cyst                                             1 (2%)                    1 (2%)                                             
      Infiltration Cellular, Lymphocyte                1 (2%)       4 (8%)                    4 (8%)                                
      Inflammation, Chronic Active                     1 (2%)                                                                       
      Acinus, Atrophy                                  3 (6%)                                                                       
      Artery, Inflammation, Chronic Active                                                    1 (2%)                                
   Salivary Glands                                    (49)         (50)         (50)         (50)                                   
      Atrophy                                          1 (2%)                                                                       
      Infiltration Cellular, Lymphocyte               31 (63%)     29 (58%)     28 (56%)     34 (68%)                               
   Stomach, Forestomach                               (49)         (50)         (50)         (50)                                   
      Hyperkeratosis                                                1 (2%)       4 (8%)                                             
      Hyperplasia, Squamous                            1 (2%)                                                                       
      Inflammation, Chronic Active                     2 (4%)                    3 (6%)                                             
      Epithelium, Hyperplasia, Squamous                5 (10%)      2 (4%)       3 (6%)       2 (4%)                                
      Epithelium, Ulcer                                                          1 (2%)                                             
   Stomach, Glandular                                 (49)         (48)         (49)         (50)                                   
      Atrophy                                                       3 (6%)      35 (71%)     45 (90%)                               
      Ectasia                                         13 (27%)     25 (52%)     40 (82%)     49 (98%)                               
      Hyperplasia                                                   1 (2%)      15 (31%)     20 (40%)                               
      Hyperplasia, Atypical                                                      1 (2%)       2 (4%)                                
      Inflammation, Chronic Active                    10 (20%)     11 (23%)     25 (51%)     33 (66%)                               
      Inflammation, Suppurative                                                               1 (2%)                                
      Mineralization                                                1 (2%)       1 (2%)       4 (8%)                                
      Necrosis                                                                   1 (2%)                                             
      Neuroendocrine Cell, Hyperplasia                                                        4 (8%)                                
   Tooth                                              (23)         (13)         (4)          (5)                                    
      Inflammation, Chronic Active                     1 (4%)       1 (8%)                    1 (20%)                               
      Malformation                                    22 (96%)     12 (92%)      4 (100%)     4 (80%)                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Heart                                              (49)         (50)         (50)         (50)                                   
      Cardiomyopathy                                                1 (2%)                    2 (4%)                                
      Mineralization                                                1 (2%)                    1 (2%)                                
      Artery, Inflammation, Chronic Active                          1 (2%)                    1 (2%)                                
      Atrium, Thrombosis                               1 (2%)       1 (2%)                    2 (4%)                                
      Valve, Inflammation, Suppurative                              1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Cortex                                     (49)         (50)         (50)         (50)                                   
      Accessory Adrenal Cortical Nodule                             2 (4%)                                                          
      Angiectasis                                                   1 (2%)       1 (2%)       1 (2%)                                
      Degeneration, Fatty                              1 (2%)       1 (2%)                                                          

a  Number of animals examined microscopically at site and number of animals with lesion                                             
NTP Experiment-Test: 05187-06         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                           METHYLEUGENOL                                       Date: 07/20/98  
Route: GAVAGE                                                                                                     Time: 10:15:51  
____________________________________________________________________________________________________________________________________

         B6C3F1 MICE MALE                          0 MG/KG      37 MG/KG     75 MG/KG     150                                       
                                                                                          MG/KG                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ENDOCRINE SYSTEM - CONT                                                                                                             
      Hypertrophy                                                   5 (10%)      3 (6%)       2 (4%)                                
      Pigmentation, Hemosiderin                                                  1 (2%)                                             
      Subcapsular, Hyperplasia                        38 (78%)     42 (84%)     44 (88%)     43 (86%)                               
   Islets, Pancreatic                                 (49)         (49)         (50)         (50)                                   
      Hyperplasia                                     32 (65%)     26 (53%)     18 (36%)     17 (34%)                               
   Pituitary Gland                                    (45)         (48)         (44)         (45)                                   
      Pars Distalis, Cyst                              5 (11%)      7 (15%)      3 (7%)       1 (2%)                                
   Thyroid Gland                                      (49)         (50)         (50)         (50)                                   
      Inflammation, Chronic Active                                  1 (2%)                    3 (6%)                                
      Follicle, Cyst                                   2 (4%)       2 (4%)       2 (4%)       2 (4%)                                
      Follicular Cell, Hyperplasia                     2 (4%)       7 (14%)      6 (12%)      5 (10%)                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Epididymis                                         (49)         (50)         (50)         (50)                                   
      Cyst                                                          1 (2%)                                                          
      Infiltration Cellular, Lymphocyte                1 (2%)       1 (2%)                    2 (4%)                                
      Mineralization                                                1 (2%)                                                          
   Preputial Gland                                    (49)         (50)         (50)         (50)                                   
      Cyst                                             7 (14%)      6 (12%)     10 (20%)      5 (10%)                               
      Infiltration Cellular, Lymphocyte               17 (35%)     15 (30%)     14 (28%)     18 (36%)                               
      Inflammation, Chronic Active                     3 (6%)       4 (8%)       8 (16%)      2 (4%)                                
   Prostate                                           (49)         (50)         (50)         (50)                                   
      Infiltration Cellular, Lymphocyte                1 (2%)                                                                       
      Inflammation, Chronic Active                     2 (4%)       2 (4%)                                                          
      Artery, Inflammation, Chronic Active                          1 (2%)                                                          
   Seminal Vesicle                                    (49)         (50)         (50)         (50)                                   
      Inflammation, Suppurative                        1 (2%)                                                                       
   Testes                                             (49)         (50)         (50)         (50)                                   
      Germinal Epithelium, Atrophy                                  1 (2%)                    1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (49)         (49)         (50)         (50)                                   
      Atrophy                                                                    1 (2%)                                             
      Hyperplasia                                     14 (29%)     26 (53%)     33 (66%)     35 (70%)                               
      Infiltration Cellular, Mast Cell                 1 (2%)                                                                       
      Necrosis                                                                   1 (2%)                                             
   Lymph Node                                         (3)          (4)          (5)          (3)                                    
      Lumbar, Hyperplasia, Plasma Cell                 1 (33%)                                                                      

a  Number of animals examined microscopically at site and number of animals with lesion                                             
NTP Experiment-Test: 05187-06         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                           METHYLEUGENOL                                       Date: 07/20/98  
Route: GAVAGE                                                                                                     Time: 10:15:51  
____________________________________________________________________________________________________________________________________

         B6C3F1 MICE MALE                          0 MG/KG      37 MG/KG     75 MG/KG     150                                       
                                                                                          MG/KG                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
HEMATOPOIETIC SYSTEM - CONT                                                                                                         
      Mediastinal, Necrosis                            1 (33%)                                                                      
      Renal, Hyperplasia, Plasma Cell                  1 (33%)                                                                      
   Lymph Node, Mandibular                             (48)         (46)         (47)         (45)                                   
      Hyperplasia, Lymphoid                                                      2 (4%)                                             
      Hyperplasia, Plasma Cell                                                   1 (2%)                                             
      Necrosis                                                      1 (2%)                                                          
   Lymph Node, Mesenteric                             (49)         (46)         (49)         (50)                                   
      Angiectasis                                                   1 (2%)                                                          
      Atrophy                                          1 (2%)                                                                       
      Congestion                                                                 1 (2%)                                             
      Ectasia                                                       1 (2%)       1 (2%)                                             
      Hematopoietic Cell Proliferation                 2 (4%)                    1 (2%)                                             
      Hyperplasia                                                                1 (2%)                                             
      Hyperplasia, Lymphoid                                                      2 (4%)       1 (2%)                                
      Inflammation, Chronic Active                     1 (2%)                                                                       
      Necrosis                                         2 (4%)       2 (4%)                    1 (2%)                                
   Spleen                                             (49)         (49)         (50)         (50)                                   
      Atrophy                                                                    2 (4%)                                             
      Fibrosis                                                      1 (2%)                                                          
      Mineralization                                                1 (2%)                                                          
      Necrosis                                                      1 (2%)                                                          
      Pigmentation, Hemosiderin                                     1 (2%)                                                          
      Lymphoid Follicle, Hyperplasia, Lymphoid         1 (2%)                    1 (2%)       3 (6%)                                
      Lymphoid Follicle, Necrosis                      3 (6%)       6 (12%)      1 (2%)       2 (4%)                                
      Red Pulp, Erythrophagocytosis                                 1 (2%)                                                          
      Red Pulp, Hematopoietic Cell Proliferation      10 (20%)     20 (41%)     25 (50%)     19 (38%)                               
   Thymus                                             (37)         (40)         (38)         (45)                                   
      Cyst                                            10 (27%)     19 (48%)     16 (42%)     12 (27%)                               
      Ectopic Parathyroid Gland                                     1 (3%)                    1 (2%)                                
      Thymocyte, Necrosis                              1 (3%)       1 (3%)                    1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Skin                                               (49)         (50)         (50)         (50)                                   
      Subcutaneous Tissue, Inflammation,                                                                                            
          Suppurative                                                                         1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Skeletal Muscle                                    (2)          (1)          (3)          (3)                                    
      Infiltration Cellular, Lymphocyte                1 (50%)                   2 (67%)      1 (33%)                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    

a  Number of animals examined microscopically at site and number of animals with lesion                                             
NTP Experiment-Test: 05187-06         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                           METHYLEUGENOL                                       Date: 07/20/98  
Route: GAVAGE                                                                                                     Time: 10:15:51  
____________________________________________________________________________________________________________________________________

         B6C3F1 MICE MALE                          0 MG/KG      37 MG/KG     75 MG/KG     150                                       
                                                                                          MG/KG                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (49)         (50)         (50)         (50)                                   
      Necrosis                                         1 (2%)                                                                       
   Spinal Cord                                        (2)                                    (2)                                    
      Hemorrhage                                                                              1 (50%)                               
      Nerve, Demyelination                                                                    1 (50%)                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (49)         (50)         (50)         (50)                                   
      Infiltration Cellular, Lymphocyte                                                       1 (2%)                                
      Inflammation, Chronic Active                     2 (4%)       2 (4%)                                                          
      Inflammation, Suppurative                        1 (2%)                    1 (2%)                                             
      Thrombosis                                                    2 (4%)                    1 (2%)                                
      Alveolar Epithelium, Hyperplasia                 7 (14%)      6 (12%)      5 (10%)      5 (10%)                               
      Alveolus, Infiltration Cellular, Lymphocyte                                1 (2%)                                             
      Alveolus, Infiltration Cellular, Histiocyte      2 (4%)       1 (2%)                    2 (4%)                                
      Bronchiole, Hyperplasia                          1 (2%)                                                                       
      Mediastinum, Inflammation, Chronic Active                                               1 (2%)                                
      Mediastinum, Necrosis                                                                   1 (2%)                                
   Nose                                               (49)         (50)         (50)         (50)                                   
      Inflammation, Chronic Active                                  1 (2%)                                                          
      Inflammation, Suppurative                        9 (18%)     13 (26%)     11 (22%)     10 (20%)                               
      Polyp, Inflammatory                              1 (2%)       1 (2%)                                                          
      Nasolacrimal Duct, Inflammation, Suppurative     4 (8%)       2 (4%)       8 (16%)      2 (4%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Eye                                                                          (1)          (1)                                    
      Cornea, Inflammation, Chronic Active                                       1 (100%)     1 (100%)                              
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (49)         (50)         (50)         (50)                                   
      Infiltration Cellular, Lymphocyte               29 (59%)     32 (64%)     27 (54%)     40 (80%)                               
      Inflammation, Chronic Active                                                            1 (2%)                                
      Inflammation, Suppurative                        1 (2%)       1 (2%)                    1 (2%)                                
      Metaplasia, Osseous                              1 (2%)       3 (6%)                    1 (2%)                                
      Mineralization                                                1 (2%)       3 (6%)       4 (8%)                                
      Necrosis                                                                                1 (2%)                                
      Nephropathy                                     43 (88%)     45 (90%)     45 (90%)     48 (96%)                               
      Artery, Inflammation, Chronic Active                          1 (2%)                                                          
      Cortex, Cyst                                    10 (20%)     27 (54%)     20 (40%)     14 (28%)                               
      Papilla, Mineralization                                       1 (2%)                                                          

a  Number of animals examined microscopically at site and number of animals with lesion                                             
NTP Experiment-Test: 05187-06         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                           METHYLEUGENOL                                       Date: 07/20/98  
Route: GAVAGE                                                                                                     Time: 10:15:51  
____________________________________________________________________________________________________________________________________

         B6C3F1 MICE MALE                          0 MG/KG      37 MG/KG     75 MG/KG     150                                       
                                                                                          MG/KG                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
URINARY SYSTEM - CONT                                                                                                               
      Papilla, Necrosis                                             1 (2%)                                                          
      Pelvis, Transitional Epithelium, Hyperplasia                  1 (2%)                                                          
      Renal Tubule, Pigmentation, Hemosiderin                                                 1 (2%)                                
   Urinary Bladder                                    (49)         (50)         (50)         (50)                                   
      Calculus Gross Observation                                    1 (2%)                                                          
      Infiltration Cellular, Lymphocyte                6 (12%)      5 (10%)      9 (18%)     14 (28%)                               
      Inflammation, Chronic Active                     1 (2%)                                                                       
                                                                                                                                    

a  Number of animals examined microscopically at site and number of animals with lesion                                             
                             ------------------------------------------------------------                                           
                             ----------              END OF REPORT             ----------                                           
                             ------------------------------------------------------------