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TDMS Study 05187-06 Pathology Tables

NTP Experiment-Test: 05187-06  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                           METHYLEUGENOL                                       Date: 07/20/98
Route: GAVAGE                                                                                                     Time: 10:21:48

                                                           CORE STUDY




       Facility:  Battelle Columbus Laboratory

       Chemical CAS #:  93-15-2

       Lock Date:  06/12/96

       Cage Range:  All

       Reasons For Removal:    All

       Removal Date Range:     All

       Treatment Groups:       Include All


































a  Number of animals examined microscopically at site and number of animals with lesion

                                                              Page   1



NTP Experiment-Test: 05187-06  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                           METHYLEUGENOL                                       Date: 07/20/98  
Route: GAVAGE                                                                                                     Time: 10:21:48  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE FEMALE                        0 MG/KG      37 MG/KG     75 MG/KG     150                                       
                                                                                          MG/KG                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
DISPOSITION SUMMARY                                                                                                                 

  Animals Initially in Study                          50           50           50           50                                     
  Early Deaths                                                                                                                      
    Moribund Sacrifice                                 5            7            8           13                                     
    Natural Death                                     14           24           23           35                                     
    Dosing Accident                                                 1            1                                                  
  Survivors                                                                                                                         
    Natural Death                                                                2                                                  
    Terminal Sacrifice                                31           18           16            2                                     

  Animals Examined Microscopically                    50           50           50           50                                     
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Gallbladder                                        (38)         (28)         (30)         (24)                                   
   Intestine Large, Colon                             (50)         (50)         (48)         (47)                                   
   Intestine Large, Rectum                            (50)         (50)         (49)         (48)                                   
      Leiomyosarcoma                                                                          1 (2%)                                
   Intestine Small, Duodenum                          (46)         (49)         (46)         (43)                                   
   Intestine Small, Jejunum                           (46)         (46)         (40)         (40)                                   
      Carcinoma                                                                  1 (3%)                                             
   Liver                                              (50)         (50)         (49)         (50)                                   
      Carcinoma, Metastatic, Ureter                                                           1 (2%)                                
      Fibrosarcoma, Metastatic, Mesentery              1 (2%)                                                                       
      Fibrosarcoma, Metastatic, Skin                                1 (2%)       1 (2%)                                             
      Hemangioma                                                    1 (2%)                                                          
      Hemangiosarcoma, Metastatic, Spleen                           1 (2%)                                                          
      Hepatoblastoma                                                6 (12%)     11 (22%)     11 (22%)                               
      Hepatoblastoma, Multiple                                                                4 (8%)                                
      Hepatocellular Carcinoma                         7 (14%)     13 (26%)     18 (37%)      9 (18%)                               
      Hepatocellular Carcinoma, Multiple                           24 (48%)     29 (59%)     38 (76%)                               
      Hepatocellular Adenoma                          12 (24%)      9 (18%)      8 (16%)      9 (18%)                               
      Hepatocellular Adenoma, Multiple                 8 (16%)     39 (78%)     38 (78%)     32 (64%)                               
      Hepatocholangiocarcinoma                                                                2 (4%)                                
      Histiocytic Sarcoma                              1 (2%)       1 (2%)                    1 (2%)                                
      Mast Cell Tumor Malignant                        1 (2%)                                                                       
      Osteosarcoma, Metastatic, Uncertain Primary                                                                                   
          Site                                                                   1 (2%)                                             
      Plasma Cell Tumor Malignant                      1 (2%)                                                                       
      Schwannoma Malignant, Metastatic, Mesentery                   1 (2%)                                                          
   Mesentery                                          (13)         (7)          (3)          (3)                                    
      Fibrosarcoma                                     1 (8%)                                                                       
      Fibrosarcoma, Metastatic, Skin                                1 (14%)      1 (33%)                                            
      Schwannoma Malignant                                          1 (14%)      1 (33%)                                            
   Pancreas                                           (49)         (50)         (46)         (46)                                   
NTP Experiment-Test: 05187-06  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                           METHYLEUGENOL                                       Date: 07/20/98  
Route: GAVAGE                                                                                                     Time: 10:21:48  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE FEMALE                        0 MG/KG      37 MG/KG     75 MG/KG     150                                       
                                                                                          MG/KG                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ALIMENTARY SYSTEM - cont                                                                                                            
      Fibrosarcoma, Metastatic, Mesentery              1 (2%)                                                                       
      Fibrosarcoma, Metastatic, Skin                                1 (2%)       1 (2%)                                             
      Schwannoma Malignant, Metastatic, Mesentery                   1 (2%)       1 (2%)                                             
   Salivary Glands                                    (50)         (45)         (44)         (42)                                   
   Stomach, Forestomach                               (50)         (50)         (48)         (46)                                   
      Squamous Cell Carcinoma                          1 (2%)                                                                       
      Squamous Cell Papilloma                                       1 (2%)       1 (2%)                                             
   Stomach, Glandular                                 (45)         (49)         (46)         (45)                                   
   Tooth                                              (2)          (1)                                                              
      Odontoma                                         1 (50%)                                                                      
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Heart                                              (50)         (50)         (48)         (44)                                   
      Histiocytic Sarcoma                              1 (2%)                                 1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Cortex                                     (50)         (50)         (50)         (49)                                   
      Adenoma                                                                                 1 (2%)                                
      Fibrosarcoma, Metastatic, Mesentery              1 (2%)                                                                       
      Fibrosarcoma, Metastatic, Skin                                1 (2%)                                                          
      Hepatocellular Carcinoma, Metastatic, Liver                                1 (2%)                                             
      Histiocytic Sarcoma                                                                     1 (2%)                                
      Plasma Cell Tumor Malignant                      1 (2%)                                                                       
   Adrenal Medulla                                    (50)         (50)         (50)         (49)                                   
      Pheochromocytoma Benign                                                    2 (4%)       1 (2%)                                
      Bilateral, Pheochromocytoma Benign                                         1 (2%)                                             
   Islets, Pancreatic                                 (49)         (50)         (46)         (47)                                   
      Adenoma                                                                                 1 (2%)                                
   Pituitary Gland                                    (48)         (44)         (44)         (40)                                   
      Pars Distalis, Adenoma                           5 (10%)      1 (2%)                    1 (3%)                                
   Thyroid Gland                                      (50)         (46)         (46)         (42)                                   
      Follicular Cell, Adenoma                         2 (4%)                    1 (2%)       1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   Peritoneum                                                      (1)                                                              
      Schwannoma Malignant, Metastatic, Mesentery                   1 (100%)                                                        
____________________________________________________________________________________________________________________________________
                                                                                                                                    
NTP Experiment-Test: 05187-06  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                           METHYLEUGENOL                                       Date: 07/20/98  
Route: GAVAGE                                                                                                     Time: 10:21:48  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE FEMALE                        0 MG/KG      37 MG/KG     75 MG/KG     150                                       
                                                                                          MG/KG                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Ovary                                              (50)         (49)         (48)         (41)                                   
      Cystadenoma                                      3 (6%)                                                                       
      Fibrosarcoma, Metastatic, Mesentery              1 (2%)                                                                       
      Fibrosarcoma, Metastatic, Skin                                1 (2%)                                                          
      Histiocytic Sarcoma                              1 (2%)                                 1 (2%)                                
      Luteoma                                          1 (2%)                    1 (2%)                                             
      Schwannoma Malignant, Metastatic, Mesentery                   1 (2%)                                                          
   Uterus                                             (50)         (50)         (49)         (47)                                   
      Histiocytic Sarcoma                              1 (2%)                                 1 (2%)                                
      Polyp Stromal                                                              1 (2%)                                             
   Vagina                                                                                    (1)                                    
      Leiomyosarcoma, Metastatic, Intestine Large,                                                                                  
           Rectum                                                                             1 (100%)                              
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (50)         (50)         (48)         (50)                                   
      Hemangiosarcoma                                                            1 (2%)                                             
      Mast Cell Tumor Malignant                        1 (2%)                                                                       
      Plasma Cell Tumor Malignant                      1 (2%)                                                                       
   Lymph Node                                         (13)         (7)          (8)          (4)                                    
      Mediastinal, Fibrosarcoma, Metastatic, Skin                                1 (13%)                                            
      Mediastinal, Hepatocellular Carcinoma,                                                                                        
          Metastatic, Liver                                                                   1 (25%)                               
      Mediastinal, Histiocytic Sarcoma                                                        1 (25%)                               
   Lymph Node, Mandibular                             (49)         (43)         (41)         (32)                                   
      Histiocytic Sarcoma                                                                     1 (3%)                                
   Lymph Node, Mesenteric                             (47)         (48)         (43)         (36)                                   
      Fibrosarcoma, Metastatic, Mesentery              1 (2%)                                                                       
      Fibrosarcoma, Metastatic, Skin                                             1 (2%)                                             
      Schwannoma Malignant, Metastatic, Mesentery                   1 (2%)                                                          
   Spleen                                             (50)         (50)         (46)         (46)                                   
      Hemangiosarcoma                                               1 (2%)                                                          
      Histiocytic Sarcoma                                           1 (2%)                                                          
      Mast Cell Tumor Malignant                        1 (2%)                                                                       
      Plasma Cell Tumor Malignant                      1 (2%)                                                                       
   Thymus                                             (45)         (43)         (40)         (33)                                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Mammary Gland                                      (50)         (48)         (50)         (37)                                   
      Adenoma                                          1 (2%)                                                                       
      Carcinoma                                        1 (2%)                                                                       
   Skin                                               (50)         (50)         (50)         (49)                                   
NTP Experiment-Test: 05187-06  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                           METHYLEUGENOL                                       Date: 07/20/98  
Route: GAVAGE                                                                                                     Time: 10:21:48  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE FEMALE                        0 MG/KG      37 MG/KG     75 MG/KG     150                                       
                                                                                          MG/KG                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
INTEGUMENTARY SYSTEM - cont                                                                                                         
      Subcutaneous Tissue, Fibrosarcoma                             4 (8%)       1 (2%)                                             
      Subcutaneous Tissue, Schwannoma Malignant        1 (2%)                                                                       
      Subcutaneous Tissue, Pinna, Fibrosarcoma                      1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Skeletal Muscle                                    (2)          (8)          (3)          (3)                                    
      Fibrosarcoma, Metastatic, Skin                                1 (13%)                                                         
      Hemangiosarcoma                                                            1 (33%)                                            
      Schwannoma Malignant, Metastatic, Skin           1 (50%)                                                                      
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (50)         (47)         (46)         (41)                                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (50)         (50)         (48)         (45)                                   
      Alveolar/Bronchiolar Adenoma                     5 (10%)      4 (8%)       1 (2%)       1 (2%)                                
      Alveolar/Bronchiolar Adenoma, Multiple           1 (2%)                                                                       
      Alveolar/Bronchiolar Carcinoma                   1 (2%)                                 1 (2%)                                
      Carcinoma, Metastatic, Harderian Gland           1 (2%)                                                                       
      Carcinoma, Metastatic, Ureter                                                           1 (2%)                                
      Hepatoblastoma, Metastatic, Liver                                          3 (6%)       4 (9%)                                
      Hepatocellular Carcinoma, Metastatic, Liver      1 (2%)       7 (14%)     23 (48%)     26 (58%)                               
      Histiocytic Sarcoma                              1 (2%)       1 (2%)                    1 (2%)                                
      Osteosarcoma, Metastatic, Uncertain Primary                                                                                   
          Site                                                                   1 (2%)                                             
      Mediastinum, Fibrosarcoma, Metastatic,                                                                                        
          Mesentery                                    1 (2%)                                                                       
   Nose                                               (50)         (50)         (49)         (47)                                   
      Carcinoma, Metastatic, Harderian Gland           1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Eye                                                (2)                       (1)                                                 
      Carcinoma, Metastatic, Harderian Gland           1 (50%)                                                                      
   Harderian Gland                                    (5)          (2)          (2)                                                 
      Adenoma                                                       2 (100%)     2 (100%)                                           
      Carcinoma                                        5 (100%)                                                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
NTP Experiment-Test: 05187-06  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                           METHYLEUGENOL                                       Date: 07/20/98  
Route: GAVAGE                                                                                                     Time: 10:21:48  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE FEMALE                        0 MG/KG      37 MG/KG     75 MG/KG     150                                       
                                                                                          MG/KG                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (50)         (50)         (50)         (49)                                   
      Hemangioma                                                                 1 (2%)                                             
      Hepatocellular Carcinoma, Metastatic, Liver                                1 (2%)                                             
      Histiocytic Sarcoma                              1 (2%)                                                                       
   Ureter                                                                                    (1)                                    
      Transitional Epithelium, Carcinoma                                                      1 (100%)                              
   Urinary Bladder                                    (50)         (49)         (47)         (46)                                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SYSTEMIC LESIONS                                                                                                                   

   Multiple Organs                                   *(50)        *(50)        *(50)        *(50)                                   
      Histiocytic Sarcoma                              1 (2%)       1 (2%)                    1 (2%)                                
      Lymphoma Malignant                              15 (30%)      8 (16%)      8 (16%)      1 (2%)                                
____________________________________________________________________________________________________________________________________
     *   Number of animals with any tissue examined microscopically                                                                 


                                                             Page   6                                                               
NTP Experiment-Test: 05187-06  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                           METHYLEUGENOL                                       Date: 07/20/98  
Route: GAVAGE                                                                                                     Time: 10:21:48  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE FEMALE                        0 MG/KG      37 MG/KG     75 MG/KG     150                                       
                                                                                          MG/KG                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
TUMOR SUMMARY                                                                                                                       
                                                                                                                                    
   Total Animals with Primary Neoplasms (b)            41          50          49          49                                       
     Total Primary Neoplasms                           79         116         128         116                                       
                                                                                                                                    
   Total Animals with Benign Neoplasms                 29          49          46          42                                       
     Total Benign Neoplasms                            39          57          57          47                                       
                                                                                                                                    
   Total Animals with Malignant Neoplasms              27          42          48          49                                       
     Total Malignant Neoplasms                         40          59          71          69                                       
                                                                                                                                    
   Total Animals with Metastatic Neoplasms              5          10          26          30                                       
     Total Metastatic Neoplasm                         11          19          36          34                                       
                                                                                                                                    
   Total Animals with Malignant Neoplasms                                       1                                                   
   Uncertain Primary Site                                                                                                           
                                                                                                                                    
   Total Animals with Neoplasms Uncertain-                                                                                          
   Benign or Malignant                                                                                                              
     Total Uncertain Neoplasms                                                                                                      
                                                                                                                                    

____________________________________________________________________________________________________________________________________
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Primary tumors: all tumors except metastatic tumors                                                                              
NTP Experiment-Test: 05187-06  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                           METHYLEUGENOL                                       Date: 07/20/98  
Route: GAVAGE                                                                                                     Time: 10:21:48  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE MALE                          0 MG/KG      37 MG/KG     75 MG/KG     150                                       
                                                                                          MG/KG                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
DISPOSITION SUMMARY                                                                                                                 

  Animals Initially in Study                          50           50           50           50                                     
  Early Deaths                                                                                                                      
    Moribund Sacrifice                                 5            6            5            9                                     
    Natural Death                                      6            8            7            4                                     
    Accidently Killed                                                            1            1                                     
    Dosing Accident                                                                           1                                     
  Survivors                                                                                                                         
    Terminal Sacrifice                                38           36           37           35                                     
  Missing                                              1                                                                            

  Animals Examined Microscopically                    49           50           50           50                                     
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Intestine Large, Cecum                             (49)         (50)         (48)         (50)                                   
      Carcinoma                                        1 (2%)                    1 (2%)                                             
      Hepatocellular Carcinoma, Metastatic, Liver                                             1 (2%)                                
   Intestine Small, Duodenum                          (47)         (47)         (48)         (50)                                   
      Polyp Adenomatous                                             1 (2%)                                                          
   Intestine Small, Jejunum                           (49)         (49)         (48)         (48)                                   
      Carcinoma                                                                               1 (2%)                                
   Intestine Small, Ileum                             (48)         (48)         (49)         (50)                                   
   Liver                                              (49)         (50)         (50)         (50)                                   
      Hemangiosarcoma                                               2 (4%)                    1 (2%)                                
      Hemangiosarcoma, Multiple                                     1 (2%)                    1 (2%)                                
      Hemangiosarcoma, Metastatic, Bone Marrow                                                1 (2%)                                
      Hemangiosarcoma, Metastatic, Skeletal Muscle                               1 (2%)                                             
      Hepatoblastoma                                                             1 (2%)       2 (4%)                                
      Hepatoblastoma, Multiple                                                                1 (2%)                                
      Hepatocellular Carcinoma                         9 (18%)     17 (34%)     16 (32%)      7 (14%)                               
      Hepatocellular Carcinoma, Multiple               1 (2%)       3 (6%)       3 (6%)       2 (4%)                                
      Hepatocellular Adenoma                          13 (27%)     10 (20%)      5 (10%)     10 (20%)                               
      Hepatocellular Adenoma, Multiple                13 (27%)     33 (66%)     33 (66%)     29 (58%)                               
      Mast Cell Tumor Malignant                                                  1 (2%)                                             
   Mesentery                                          (1)          (2)          (1)          (1)                                    
      Fibrous Histiocytoma                                          1 (50%)                                                         
      Hemangiosarcoma, Metastatic, Lymph Node,                                                                                      
           Mesenteric                                  1 (100%)                                                                     
   Oral Mucosa                                                                               (1)                                    
      Pharyngeal, Squamous Cell Carcinoma                                                     1 (100%)                              
   Pancreas                                           (49)         (49)         (50)         (50)                                   
      Alveolar/Bronchiolar Carcinoma, Metastatic,                                                                                   
           Lung                                        1 (2%)                                                                       
      Fibrous Histiocytoma, Metastatic, Lymph Node                               1 (2%)                                             
NTP Experiment-Test: 05187-06  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                           METHYLEUGENOL                                       Date: 07/20/98  
Route: GAVAGE                                                                                                     Time: 10:21:48  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE MALE                          0 MG/KG      37 MG/KG     75 MG/KG     150                                       
                                                                                          MG/KG                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ALIMENTARY SYSTEM - cont                                                                                                            
      Fibrous Histiocytoma, Metastatic, Mesentery                   1 (2%)                                                          
      Mast Cell Tumor Malignant                                                  1 (2%)                                             
   Salivary Glands                                    (49)         (50)         (50)         (50)                                   
   Stomach, Forestomach                               (49)         (50)         (50)         (50)                                   
      Squamous Cell Papilloma                                       1 (2%)                    2 (4%)                                
   Stomach, Glandular                                 (49)         (48)         (49)         (50)                                   
      Carcinoma                                                                               1 (2%)                                
      Neuroendocrine Tumor, Malignant                                                         2 (4%)                                
   Tooth                                              (23)         (13)         (4)          (5)                                    
      Odontoma                                         1 (4%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Heart                                              (49)         (50)         (50)         (50)                                   
      Alveolar/Bronchiolar Carcinoma, Metastatic,                                                                                   
           Lung                                        1 (2%)                    1 (2%)                                             
      Fibrous Histiocytoma, Metastatic, Mesentery                   1 (2%)                                                          
      Hemangiosarcoma                                               1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Cortex                                     (49)         (50)         (50)         (50)                                   
      Adenoma                                                       1 (2%)                    1 (2%)                                
      Alveolar/Bronchiolar Carcinoma, Metastatic,                                                                                   
           Lung                                        1 (2%)                                                                       
   Islets, Pancreatic                                 (49)         (49)         (50)         (50)                                   
      Adenoma                                                                                 1 (2%)                                
   Thyroid Gland                                      (49)         (50)         (50)         (50)                                   
      Follicular Cell, Adenoma                         1 (2%)                    1 (2%)       1 (2%)                                
      Follicular Cell, Carcinoma                       1 (2%)                    1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Epididymis                                         (49)         (50)         (50)         (50)                                   
      Fibrous Histiocytoma, Metastatic, Mesentery                   1 (2%)                                                          
   Preputial Gland                                    (49)         (50)         (50)         (50)                                   
   Prostate                                           (49)         (50)         (50)         (50)                                   
      Carcinoma                                        1 (2%)                                                                       
   Seminal Vesicle                                    (49)         (50)         (50)         (50)                                   
NTP Experiment-Test: 05187-06  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                           METHYLEUGENOL                                       Date: 07/20/98  
Route: GAVAGE                                                                                                     Time: 10:21:48  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE MALE                          0 MG/KG      37 MG/KG     75 MG/KG     150                                       
                                                                                          MG/KG                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
GENITAL SYSTEM - cont                                                                                                               
      Alveolar/Bronchiolar Carcinoma, Metastatic,                                                                                   
           Lung                                        1 (2%)                                                                       
      Fibrous Histiocytoma, Metastatic, Mesentery                   1 (2%)                                                          
   Testes                                             (49)         (50)         (50)         (50)                                   
      Interstitial Cell, Adenoma                       1 (2%)                    1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (49)         (49)         (50)         (50)                                   
      Hemangioma                                                                 1 (2%)                                             
      Hemangiosarcoma                                               1 (2%)                    1 (2%)                                
      Hemangiosarcoma, Metastatic, Spleen              1 (2%)       1 (2%)                                                          
      Hemangiosarcoma, Metastatic, Skeletal Muscle     1 (2%)                                                                       
   Lymph Node                                         (3)          (4)          (5)          (3)                                    
      Lumbar, Fibrous Histiocytoma, Metastatic,                                                                                     
           Mesentery                                                1 (25%)                                                         
      Mediastinal, Fibrous Histiocytoma,                                                                                            
          Metastatic, Mesentery                                     1 (25%)                                                         
      Pancreatic, Fibrous Histiocytoma                                           1 (20%)                                            
      Renal, Fibrous Histiocytoma, Metastatic,                                                                                      
           Mesentery                                                1 (25%)                                                         
   Lymph Node, Mandibular                             (48)         (46)         (47)         (45)                                   
   Lymph Node, Mesenteric                             (49)         (46)         (49)         (50)                                   
      Fibrous Histiocytoma, Metastatic, Mesentery                   1 (2%)                                                          
      Hemangiosarcoma                                  1 (2%)                                                                       
      Hemangiosarcoma, Metastatic, Spleen              1 (2%)                                                                       
   Spleen                                             (49)         (49)         (50)         (50)                                   
      Hemangioma                                                                 1 (2%)                                             
      Hemangiosarcoma                                  2 (4%)       2 (4%)                                                          
      Hemangiosarcoma, Metastatic, Skeletal Muscle                               1 (2%)                                             
      Mast Cell Tumor Malignant                                                  1 (2%)                                             
   Thymus                                             (37)         (40)         (38)         (45)                                   
      Alveolar/Bronchiolar Carcinoma, Metastatic,                                                                                   
           Lung                                        1 (3%)                                                                       
      Fibrous Histiocytoma, Metastatic, Mesentery                   1 (3%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Skin                                               (49)         (50)         (50)         (50)                                   
      Subcutaneous Tissue, Fibrosarcoma                                                       1 (2%)                                
      Subcutaneous Tissue, Hemangiosarcoma                                       1 (2%)       1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
NTP Experiment-Test: 05187-06  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                           METHYLEUGENOL                                       Date: 07/20/98  
Route: GAVAGE                                                                                                     Time: 10:21:48  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE MALE                          0 MG/KG      37 MG/KG     75 MG/KG     150                                       
                                                                                          MG/KG                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Bone                                               (49)         (50)         (50)         (50)                                   
      Vertebra, Osteosarcoma                                                                  1 (2%)                                
   Skeletal Muscle                                    (2)          (1)          (3)          (3)                                    
      Hemangiosarcoma                                  1 (50%)                   1 (33%)      2 (67%)                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (49)         (50)         (50)         (50)                                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (49)         (50)         (50)         (50)                                   
      Alveolar/Bronchiolar Adenoma                    10 (20%)      9 (18%)     17 (34%)     14 (28%)                               
      Alveolar/Bronchiolar Adenoma, Multiple           1 (2%)       1 (2%)       2 (4%)       1 (2%)                                
      Alveolar/Bronchiolar Carcinoma                   4 (8%)       4 (8%)       5 (10%)      6 (12%)                               
      Alveolar/Bronchiolar Carcinoma, Multiple         1 (2%)                    2 (4%)                                             
      Fibrous Histiocytoma, Metastatic, Mesentery                   1 (2%)                                                          
      Hemangiosarcoma, Metastatic, Skeletal Muscle                               1 (2%)                                             
      Hepatocellular Carcinoma, Metastatic, Liver      2 (4%)       6 (12%)      7 (14%)      4 (8%)                                
      Osteosarcoma, Metastatic, Uncertain Primary                                                                                   
          Site                                                      1 (2%)                                                          
      Mediastinum, Alveolar/Bronchiolar Carcinoma,                                                                                  
           Metastatic, Lung                            1 (2%)                    2 (4%)                                             
      Mediastinum, Fibrous Histiocytoma,                                                                                            
          Metastatic, Mesentery                                     1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Harderian Gland                                    (4)          (1)          (7)          (6)                                    
      Adenoma                                          4 (100%)     1 (100%)     7 (100%)     6 (100%)                              
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (49)         (50)         (50)         (50)                                   
      Alveolar/Bronchiolar Carcinoma, Metastatic,                                                                                   
           Lung                                        1 (2%)                    1 (2%)                                             
      Fibrous Histiocytoma, Metastatic, Mesentery                   1 (2%)                                                          
   Urinary Bladder                                    (49)         (50)         (50)         (50)                                   
NTP Experiment-Test: 05187-06  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                           METHYLEUGENOL                                       Date: 07/20/98  
Route: GAVAGE                                                                                                     Time: 10:21:48  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE MALE                          0 MG/KG      37 MG/KG     75 MG/KG     150                                       
                                                                                          MG/KG                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
 SYSTEMIC LESIONS                                                                                                                   

   Multiple Organs                                   *(49)        *(50)        *(50)        *(50)                                   
      Lymphoma Malignant                               3 (6%)       3 (6%)       8 (16%)      6 (12%)                               
____________________________________________________________________________________________________________________________________
     *   Number of animals with any tissue examined microscopically                                                                 


                                                             Page  12                                                               
NTP Experiment-Test: 05187-06  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                           METHYLEUGENOL                                       Date: 07/20/98  
Route: GAVAGE                                                                                                     Time: 10:21:48  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE MALE                          0 MG/KG      37 MG/KG     75 MG/KG     150                                       
                                                                                          MG/KG                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
TUMOR SUMMARY                                                                                                                       
                                                                                                                                    
   Total Animals with Primary Neoplasms (b)            41          48          49          45                                       
     Total Primary Neoplasms                           69          92         111         102                                       
                                                                                                                                    
   Total Animals with Benign Neoplasms                 33          43          42          44                                       
     Total Benign Neoplasms                            44          57          68          65                                       
                                                                                                                                    
   Total Animals with Malignant Neoplasms              23          29          32          29                                       
     Total Malignant Neoplasms                         25          35          43          35                                       
                                                                                                                                    
   Total Animals with Metastatic Neoplasms              6           9          10           6                                       
     Total Metastatic Neoplasm                         13          20          15           6                                       
                                                                                                                                    
   Total Animals with Malignant Neoplasms                           1                                                               
   Uncertain Primary Site                                                                                                           
                                                                                                                                    
   Total Animals with Neoplasms Uncertain-                                                                                          
   Benign or Malignant                                                                      2                                       
     Total Uncertain Neoplasms                                                              2                                       
                                                                                                                                    

____________________________________________________________________________________________________________________________________
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Primary tumors: all tumors except metastatic tumors                                                                              
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                             ----------              END OF REPORT             ----------                                           
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