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TDMS Study 05187-06 Pathology Tables

NTP                                        STATISTICAL ANALYSIS OF PRIMARY TUMORS                              REPORT: PEIRPT08     
LAB: Battelle Columbus                                       METHYLEUGENOL                                     DATE: 07/20/98       
EXPERIMENT: 05187 TEST: 06                                                                                     TIME: 10:22:14       
TEST TYPE:  CHRONIC                             CAGES FROM 0000 TO LAST CAGE                                   PAGE:       1        
CONT: NO1-ES-25337                              ROUTE: GAVAGE                                                  NTP C#: 60991B       
PATHOLOGIST: TOFT, J.                                                                                          CAS: 93-15-2         
------------------------------------------------------------------------------------------------------------------------------------
                                                                                                                                    
                                                             CORE STUDY                                                             
                                                                                                                                    

               REASONS FOR REMOVAL:    ALL                                                                                          
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
               REMOVAL DATE RANGE:     ALL                                                                                          
                                                                                                                                    
               TREATMENT GROUPS:       INCLUDE ALL                                                                                  
NTP                                        STATISTICAL ANALYSIS OF PRIMARY TUMORS                              REPORT: PEIRPT08
LAB: Battelle Columbus                                       METHYLEUGENOL                                     DATE: 07/20/98

EXPERIMENT: 05187 TEST: 06                                                                                     TIME: 10:22:14
TEST TYPE:  CHRONIC                             CAGES FROM 0000 TO LAST CAGE
CONT: NO1-ES-25337                              ROUTE: GAVAGE                                                  NTP C#: 60991B
PATHOLOGIST: TOFT, J.                                                                                          CAS: 93-15-2

Mice(B6C3F1)
-----------------------------
FOR ALL DOSES THE TUMOR RATES IN THE FOLLOWING TISSUES/ORGANS ARE
BASED ON NUMBER OF TISSUES EXAMINED.  IN OTHER TISSUES/ORGANS RATES
ARE BASED ON THE NUMBER OF ANIMALS NECROPSIED.
                                                 ---------------
                                                 Adrenal Cortex
                                                 Adrenal Medulla
                                                 Bone Marrow
                                                 Heart
                                                 Islets, Pancreatic
                                                 Kidney
                                                 Liver
                                                 Lung
                                                 Ovary
                                                 Pancreas
                                                 Pituitary Gland
                                                 Prostate
                                                 Spleen
                                                 Testes
                                                 Thyroid Gland
NTP                                        STATISTICAL ANALYSIS OF PRIMARY TUMORS                              REPORT: PEIRPT08   
LAB: Battelle Columbus                                       METHYLEUGENOL                                     DATE: 07/20/98     
EXPERIMENT: 05187 TEST: 06                                                                                     TIME: 10:22:14     
TEST TYPE:  CHRONIC                             CAGES FROM 0000 TO LAST CAGE                                                      
CONT: NO1-ES-25337                              ROUTE: GAVAGE                                                  NTP C#: 60991B     
PATHOLOGIST: TOFT, J.                                                                                          CAS: 93-15-2       



SUMMARY OF STATISTICALLY SIGNIFICANT (P<=.05) RESULTS
IN THE ANALYSIS OF                  METHYLEUGENOL
===============================================================

Male Mice
------------
Organ                                 Morphology
-----                                 ----------
Liver                                  Hepatoblastoma
                                       Hepatocellular Adenoma
                                       Hepatocellular Carcinoma
                                       Hepatocellular Carcinoma or Hepatoblastoma
                                       Hepatocellular Carcinoma or Hepatocellular Adenoma
                                       Hepatocellular Carcinoma, Hepatocellular Adenoma, or Hepatoblastoma
Lung                                   Alveolar/Bronchiolar Carcinoma or Alveolar/Bronchiolar Adenoma
Stomach, Glandular                     Neuroendocrine Tumor, Malignant
All Organs                             Benign Tumors
                                       Malignant and Benign Tumors
===============================================================
Female Mice
------------
Organ                                  Morphology
-----                                  ----------
Adrenal Medulla                        Pheochromocytoma Benign
Harderian Gland                        Carcinoma
                                       Carcinoma or Adenoma
Liver                                  Hepatoblastoma
                                       Hepatocellular Adenoma
                                       Hepatocellular Carcinoma
                                       Hepatocellular Carcinoma or Hepatoblastoma
                                       Hepatocellular Carcinoma or Hepatocellular Adenoma
                                       Hepatocellular Carcinoma, Hepatocellular Adenoma, or Hepatoblastoma
                                       Hepatocholangiocarcinoma
Lung                                   Alveolar/Bronchiolar Adenoma
                                       Alveolar/Bronchiolar Carcinoma or Alveolar/Bronchiolar Adenoma
Ovary                                  Cystadenoma
Pituitary Gland: Pars Distalis or Unspecified Site
                                       Adenoma
Skin                                   Fibrosarcoma
All Organs                             Hemangiosarcoma or Hemangioma
                                       Malignant Lymphoma: Histiocytic, Lymphocytic, Mixed, NOS, or Undifferentiated Cell Type
                                       Benign Tumors
                                       Malignant Tumors
                                       Malignant and Benign Tumors
===============================================================
       Date:  07/20/98                           EXPERIMENT: 05187 TEST: 06                                            Page 1
                     Statistical Analysis of Primary Tumors in Mice(B6C3F1)        -                   METHYLEUGENOL
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 MG/KG      37 MG/KG     75 MG/KG     150         |0 MG/KG      37 MG/KG     75 MG/KG     150          |
|                   |                                            MG/KG       |                                       MG/KG        |
|=================================================================================================================================|
|                                                                                                                                 |
|Adrenal Medulla                                                                                                                  |
|     Pheochromocytoma Benign                                                                                                     |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     0/49 (0%)    0/50 (0%)    0/50 (0%)    0/50 (0%)   |0/50 (0%)    0/50 (0%)    3/50 (6%)    1/49 (2%)    |
|POLY-3 ADJUSTED (b)|     0.0%         0.0%         0.0%         0.0%        |0.0%         0.0%         7.6%         3.0%         |
|TERMINAL (d)       |     0/38 (0%)    0/36 (0%)    0/37 (0%)    0/35 (0%)   |0/31 (0%)    0/18 (0%)    2/18 (11%)   1/2 (50%)    |
|FIRST INCIDENCE    |     ---          ---          ---          ---         |---          ---          659          731 (T)      |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     (e)          (e)          (e)          (e)         |P=0.015 *    (e)          P=0.055      P=0.033 *    |
|POLY 3             |     (e)          (e)          (e)          (e)         |P=0.149      (e)          P=0.098      P=0.445      |
|POLY 1.5           |     (e)          (e)          (e)          (e)         |P=0.190      (e)          P=0.107      P=0.469      |
|POLY 6             |     (e)          (e)          (e)          (e)         |P=0.093      (e)          P=0.087      P=0.406      |
|LOGISTIC REGRESSION|     (e)          (e)          (e)          (e)         |P=0.091      (e)          P=0.088      P=0.033 *    |
|COCH-ARM / FISHERS |     (e)          (e)          (e)          (e)         |P=0.241      (e)          P=0.121      P=0.495      |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 MG/KG      37 MG/KG     75 MG/KG     150         |0 MG/KG      37 MG/KG     75 MG/KG     150          |
|                   |                                            MG/KG       |                                       MG/KG        |
|=================================================================================================================================|
|                                                                                                                                 |
|Harderian Gland                                                                                                                  |
|     Adenoma                                                                                                                     |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     4/50 (8%)    1/50 (2%)    7/50 (14%)   6/50 (12%)  |0/50 (0%)    2/50 (4%)    2/50 (4%)    0/50 (0%)    |
|POLY-3 ADJUSTED (b)|     9.0%         2.2%         16.2%        13.7%       |0.0%         5.2%         5.1%         0.0%         |
|TERMINAL (d)       |     3/38 (8%)    1/36 (3%)    7/37 (19%)   5/35 (14%)  |0/31 (0%)    1/18 (6%)    0/18 (0%)    0/2 (0%)     |
|FIRST INCIDENCE    |     570          730 (T)      730 (T)      569         |---          720          659          ---          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.113      P=0.189N     P=0.249      P=0.329     |P=0.397      P=0.146      P=0.155      (e)          |
|POLY 3             |     P=0.123      P=0.168N     P=0.247      P=0.362     |P=0.617N     P=0.206      P=0.211      (e)          |
|POLY 1.5           |     P=0.127      P=0.172N     P=0.248      P=0.365     |P=0.560N     P=0.221      P=0.223      (e)          |
|POLY 6             |     P=0.119      P=0.168N     P=0.246      P=0.358     |P=0.490      P=0.186      P=0.196      (e)          |
|LOGISTIC REGRESSION|     P=0.126      P=0.178N     P=0.256      P=0.366     |P=0.618      P=0.149      P=0.217      (e)          |
|COCH-ARM / FISHERS |     P=0.137      P=0.181N     P=0.262      P=0.370     |P=0.498N     P=0.247      P=0.247      (e)          |
|=================================================================================================================================|
       Date:  07/20/98                           EXPERIMENT: 05187 TEST: 06                                            Page 2
                     Statistical Analysis of Primary Tumors in Mice(B6C3F1)       -                   METHYLEUGENOL
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 MG/KG      37 MG/KG     75 MG/KG     150         |0 MG/KG      37 MG/KG     75 MG/KG     150          |
|                   |                                            MG/KG       |                                       MG/KG        |
|=================================================================================================================================|
|                                                                                                                                 |
|Harderian Gland                                                                                                                  |
|     Carcinoma                                                                                                                   |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     0/50 (0%)    0/50 (0%)    0/50 (0%)    0/50 (0%)   |5/50 (10%)   0/50 (0%)    0/50 (0%)    0/50 (0%)    |
|POLY-3 ADJUSTED (b)|     0.0%         0.0%         0.0%         0.0%        |11.1%        0.0%         0.0%         0.0%         |
|TERMINAL (d)       |     0/38 (0%)    0/36 (0%)    0/37 (0%)    0/35 (0%)   |2/31 (7%)    0/18 (0%)    0/18 (0%)    0/2 (0%)     |
|FIRST INCIDENCE    |     ---          ---          ---          ---         |652          ---          ---          ---          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     (e)          (e)          (e)          (e)         |P=0.038N*    P=0.100N     P=0.090N     P=0.282N     |
|POLY 3             |     (e)          (e)          (e)          (e)         |P=0.006N**   P=0.046N*    P=0.044N*    P=0.061N     |
|POLY 1.5           |     (e)          (e)          (e)          (e)         |P=0.007N**   P=0.038N*    P=0.037N*    P=0.044N*    |
|POLY 6             |     (e)          (e)          (e)          (e)         |P=0.006N**   P=0.062N     P=0.055N     P=0.100N     |
|LOGISTIC REGRESSION|     (e)          (e)          (e)          (e)         |P=0.014N*    P=0.044N*    P=0.041N*    P=0.065N     |
|COCH-ARM / FISHERS |     (e)          (e)          (e)          (e)         |P=0.009N**   P=0.028N*    P=0.028N*    P=0.028N*    |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 MG/KG      37 MG/KG     75 MG/KG     150         |0 MG/KG      37 MG/KG     75 MG/KG     150          |
|                   |                                            MG/KG       |                                       MG/KG        |
|=================================================================================================================================|
|                                                                                                                                 |
|Harderian Gland                                                                                                                  |
|     Carcinoma or Adenoma                                                                                                        |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     4/50 (8%)    1/50 (2%)    7/50 (14%)   6/50 (12%)  |5/50 (10%)   2/50 (4%)    2/50 (4%)    0/50 (0%)    |
|POLY-3 ADJUSTED (b)|     9.0%         2.2%         16.2%        13.7%       |11.1%        5.2%         5.1%         0.0%         |
|TERMINAL (d)       |     3/38 (8%)    1/36 (3%)    7/37 (19%)   5/35 (14%)  |2/31 (7%)    1/18 (6%)    0/18 (0%)    0/2 (0%)     |
|FIRST INCIDENCE    |     570          730 (T)      730 (T)      569         |652          720          659          ---          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.113      P=0.189N     P=0.249      P=0.329     |P=0.184N     P=0.451N     P=0.422N     P=0.282N     |
|POLY 3             |     P=0.123      P=0.168N     P=0.247      P=0.362     |P=0.033N*    P=0.285N     P=0.274N     P=0.061N     |
|POLY 1.5           |     P=0.127      P=0.172N     P=0.248      P=0.365     |P=0.027N*    P=0.250N     P=0.247N     P=0.044N*    |
|POLY 6             |     P=0.119      P=0.168N     P=0.246      P=0.358     |P=0.048N*    P=0.340N     P=0.312N     P=0.100N     |
|LOGISTIC REGRESSION|     P=0.126      P=0.178N     P=0.256      P=0.366     |P=0.052N     P=0.317N     P=0.257N     P=0.065N     |
|COCH-ARM / FISHERS |     P=0.137      P=0.181N     P=0.262      P=0.370     |P=0.022N*    P=0.218N     P=0.218N     P=0.028N*    |
|=================================================================================================================================|
       Date:  07/20/98                           EXPERIMENT: 05187 TEST: 06                                            Page 3
                     Statistical Analysis of Primary Tumors in Mice(B6C3F1)       -                   METHYLEUGENOL
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 MG/KG      37 MG/KG     75 MG/KG     150         |0 MG/KG      37 MG/KG     75 MG/KG     150          |
|                   |                                            MG/KG       |                                       MG/KG        |
|=================================================================================================================================|
|                                                                                                                                 |
|Liver                                                                                                                            |
|     Hemangiosarcoma                                                                                                             |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     0/49 (0%)    3/50 (6%)    0/50 (0%)    2/50 (4%)   |0/50 (0%)    0/50 (0%)    0/49 (0%)    0/50 (0%)    |
|POLY-3 ADJUSTED (b)|     0.0%         6.5%         0.0%         4.6%        |0.0%         0.0%         0.0%         0.0%         |
|TERMINAL (d)       |     0/38 (0%)    2/36 (6%)    0/37 (0%)    2/35 (6%)   |0/31 (0%)    0/18 (0%)    0/18 (0%)    0/2 (0%)     |
|FIRST INCIDENCE    |     ---          614          ---          730 (T)     |---          ---          ---          ---          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.333      P=0.125      (e)          P=0.220     |(e)          (e)          (e)          (e)          |
|POLY 3             |     P=0.351      P=0.130      (e)          P=0.236     |(e)          (e)          (e)          (e)          |
|POLY 1.5           |     P=0.353      P=0.128      (e)          P=0.238     |(e)          (e)          (e)          (e)          |
|POLY 6             |     P=0.347      P=0.132      (e)          P=0.234     |(e)          (e)          (e)          (e)          |
|LOGISTIC REGRESSION|     P=0.350      P=0.118      (e)          P=0.220     |(e)          (e)          (e)          (e)          |
|COCH-ARM / FISHERS |     P=0.359      P=0.125      (e)          P=0.253     |(e)          (e)          (e)          (e)          |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 MG/KG      37 MG/KG     75 MG/KG     150         |0 MG/KG      37 MG/KG     75 MG/KG     150          |
|                   |                                            MG/KG       |                                       MG/KG        |
|=================================================================================================================================|
|                                                                                                                                 |
|Liver                                                                                                                            |
|     Hepatoblastoma                                                                                                              |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     0/49 (0%)    0/50 (0%)    1/50 (2%)    3/50 (6%)   |0/50 (0%)    6/50 (12%)   11/49 (22%)  15/50 (30%)  |
|POLY-3 ADJUSTED (b)|     0.0%         0.0%         2.3%         6.8%        |0.0%         15.3%        27.4%        39.3%        |
|TERMINAL (d)       |     0/38 (0%)    0/36 (0%)    1/37 (3%)    1/35 (3%)   |0/31 (0%)    2/18 (11%)   6/18 (33%)   2/2 (100%)   |
|FIRST INCIDENCE    |     ---          ---          730 (T)      554         |---          627          628          505          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.019 *    (e)          P=0.495      P=0.121     |P<0.001 **   P=0.004 **   P<0.001 **   P<0.001 **   |
|POLY 3             |     P=0.019 *    (e)          P=0.500      P=0.122     |P<0.001 **   P=0.009 **   P<0.001 **   P<0.001 **   |
|POLY 1.5           |     P=0.019 *    (e)          P=0.500      P=0.122     |P<0.001 **   P=0.012 *    P<0.001 **   P<0.001 **   |
|POLY 6             |     P=0.019 *    (e)          P=0.500      P=0.123     |P<0.001 **   P=0.007 **   P<0.001 **   P<0.001 **   |
|LOGISTIC REGRESSION|     P=0.022 *    (e)          P=0.495      P=0.138     |P<0.001 **   P=0.010 *    P<0.001 **   P<0.001 **   |
|COCH-ARM / FISHERS |     P=0.021 *    (e)          P=0.505      P=0.125     |P<0.001 **   P=0.013 *    P<0.001 **   P<0.001 **   |
|=================================================================================================================================|
       Date:  07/20/98                           EXPERIMENT: 05187 TEST: 06                                            Page 4
                     Statistical Analysis of Primary Tumors in Mice(B6C3F1)       -                   METHYLEUGENOL
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 MG/KG      37 MG/KG     75 MG/KG     150         |0 MG/KG      37 MG/KG     75 MG/KG     150          |
|                   |                                            MG/KG       |                                       MG/KG        |
|=================================================================================================================================|
|                                                                                                                                 |
|Liver                                                                                                                            |
|     Hepatocellular Adenoma                                                                                                      |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     26/49 (53%)  43/50 (86%)  38/50 (76%)  39/50 (78%) |20/50 (40%)  48/50 (96%)  46/49 (94%)  41/50 (82%)  |
|POLY-3 ADJUSTED (b)|     57.1%        91.1%        85.8%        84.0%       |44.4%        96.6%        94.4%        86.5%        |
|TERMINAL (d)       |     22/38 (58%)  35/36 (97%)  35/37 (95%)  30/35 (86%) |16/31 (52%)  18/18 (100%) 16/18 (89%)  1/2 (50%)    |
|FIRST INCIDENCE    |     430          614          589          512         |665          477          465          450          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.008 **   P<0.001 **   P=0.005 **   P=0.004 **  |P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 **   |
|POLY 3             |     P=0.006 **   P<0.001 **   P<0.001 **   P=0.003 **  |P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 **   |
|POLY 1.5           |     P=0.010 *    P<0.001 **   P=0.003 **   P=0.003 **  |P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 **   |
|POLY 6             |     P=0.005 **   P<0.001 **   P<0.001 **   P=0.002 **  |P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 **   |
|LOGISTIC REGRESSION|     P=0.007 **   P<0.001 **   P=0.006 **   P=0.005 **  |P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 **   |
|COCH-ARM / FISHERS |     P=0.032 *    P<0.001 **   P=0.014 *    P=0.008 **  |P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 **   |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 MG/KG      37 MG/KG     75 MG/KG     150         |0 MG/KG      37 MG/KG     75 MG/KG     150          |
|                   |                                            MG/KG       |                                       MG/KG        |
|=================================================================================================================================|
|                                                                                                                                 |
|Liver                                                                                                                            |
|     Hepatocellular Carcinoma                                                                                                    |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     10/49 (20%)  20/50 (40%)  19/50 (38%)  9/50 (18%)  |7/50 (14%)   37/50 (74%)  47/49 (96%)  47/50 (94%)  |
|POLY-3 ADJUSTED (b)|     21.8%        41.8%        40.1%        20.4%       |15.5%        79.5%        96.5%        96.4%        |
|TERMINAL (d)       |     5/38 (13%)   10/36 (28%)  10/37 (27%)  6/35 (17%)  |3/31 (10%)   13/18 (72%)  17/18 (94%)  2/2 (100%)   |
|FIRST INCIDENCE    |     477          593          486          579         |665          493          465          450          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.325N     P=0.043 *    P=0.055      P=0.549N    |P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 **   |
|POLY 3             |     P=0.309N     P=0.030 *    P=0.044 *    P=0.539N    |P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 **   |
|POLY 1.5           |     P=0.275N     P=0.028 *    P=0.040 *    P=0.517N    |P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 **   |
|POLY 6             |     P=0.350N     P=0.031 *    P=0.049 *    P=0.566N    |P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 **   |
|LOGISTIC REGRESSION|     P=0.210N     P=0.019 *    P=0.054      P=0.466N    |P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 **   |
|COCH-ARM / FISHERS |     P=0.228N     P=0.028 *    P=0.044 *    P=0.480N    |P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 **   |
|=================================================================================================================================|
       Date:  07/20/98                           EXPERIMENT: 05187 TEST: 06                                            Page 5
                     Statistical Analysis of Primary Tumors in Mice(B6C3F1)       -                   METHYLEUGENOL
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 MG/KG      37 MG/KG     75 MG/KG     150         |0 MG/KG      37 MG/KG     75 MG/KG     150          |
|                   |                                            MG/KG       |                                       MG/KG        |
|=================================================================================================================================|
|                                                                                                                                 |
|Liver                                                                                                                            |
|     Hepatocellular Carcinoma or Hepatoblastoma                                                                                  |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     10/49 (20%)  20/50 (40%)  20/50 (40%)  11/50 (22%) |7/50 (14%)   38/50 (76%)  48/49 (98%)  49/50 (98%)  |
|POLY-3 ADJUSTED (b)|     21.8%        41.8%        42.2%        24.6%       |15.5%        81.0%        98.0%        99.7%        |
|TERMINAL (d)       |     5/38 (13%)   10/36 (28%)  11/37 (30%)  7/35 (20%)  |3/31 (10%)   13/18 (72%)  17/18 (94%)  2/2 (100%)   |
|FIRST INCIDENCE    |     477          593          486          554         |665          493          465          450          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.502N     P=0.043 *    P=0.038 *    P=0.451     |P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 **   |
|POLY 3             |     P=0.490N     P=0.030 *    P=0.027 *    P=0.471     |P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 **   |
|POLY 1.5           |     P=0.458N     P=0.028 *    P=0.025 *    P=0.490     |P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 **   |
|POLY 6             |     P=0.526N     P=0.031 *    P=0.031 *    P=0.449     |P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 **   |
|LOGISTIC REGRESSION|     P=0.380N     P=0.019 *    P=0.035 *    P=0.540     |P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 **   |
|COCH-ARM / FISHERS |     P=0.404N     P=0.028 *    P=0.028 *    P=0.521     |P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 **   |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 MG/KG      37 MG/KG     75 MG/KG     150         |0 MG/KG      37 MG/KG     75 MG/KG     150          |
|                   |                                            MG/KG       |                                       MG/KG        |
|=================================================================================================================================|
|                                                                                                                                 |
|Liver                                                                                                                            |
|     Hepatocellular Carcinoma or Hepatocellular Adenoma                                                                          |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     31/49 (63%)  47/50 (94%)  46/50 (92%)  40/50 (80%) |25/50 (50%)  50/50 (100%) 49/49 (100%) 49/50 (98%)  |
|POLY-3 ADJUSTED (b)|     65.4%        97.4%        96.4%        85.6%       |54.8%        100.0%       100.0%       99.7%        |
|TERMINAL (d)       |     23/38 (61%)  36/36 (100%) 36/37 (97%)  30/35 (86%) |18/31 (58%)  18/18 (100%) 18/18 (100%) 2/2 (100%)   |
|FIRST INCIDENCE    |     430          593          486          512         |665          477          465          450          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.069      P=0.002 **   P=0.004 **   P=0.036 *   |P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 **   |
|POLY 3             |     P=0.018 *    P<0.001 **   P<0.001 **   P=0.016 *   |P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 **   |
|POLY 1.5           |     P=0.033 *    P<0.001 **   P<0.001 **   P=0.024 *   |P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 **   |
|POLY 6             |     P=0.012 *    P<0.001 **   P<0.001 **   P=0.012 *   |P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 **   |
|LOGISTIC REGRESSION|     P=0.066      P<0.001 **   P<0.001 **   P=0.043 *   |P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 **   |
|COCH-ARM / FISHERS |     P=0.116      P<0.001 **   P<0.001 **   P=0.052     |P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 **   |
|=================================================================================================================================|
       Date:  07/20/98                           EXPERIMENT: 05187 TEST: 06                                            Page 6
                     Statistical Analysis of Primary Tumors in Mice(B6C3F1)       -                   METHYLEUGENOL
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 MG/KG      37 MG/KG     75 MG/KG     150         |0 MG/KG      37 MG/KG     75 MG/KG     150          |
|                   |                                            MG/KG       |                                       MG/KG        |
|=================================================================================================================================|
|                                                                                                                                 |
|Liver                                                                                                                            |
|     Hepatocellular Carcinoma, Hepatocellular Adenoma,                                                                           |
|     or Hepatoblastoma                                                                                                           |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     31/49 (63%)  47/50 (94%)  46/50 (92%)  41/50 (82%) |25/50 (50%)  50/50 (100%) 49/49 (100%) 49/50 (98%)  |
|POLY-3 ADJUSTED (b)|     65.4%        97.4%        96.4%        86.7%       |54.8%        100.0%       100.0%       99.7%        |
|TERMINAL (d)       |     23/38 (61%)  36/36 (100%) 36/37 (97%)  30/35 (86%) |18/31 (58%)  18/18 (100%) 18/18 (100%) 2/2 (100%)   |
|FIRST INCIDENCE    |     430          593          486          512         |665          477          465          450          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.048 *    P=0.002 **   P=0.004 **   P=0.026 *   |P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 **   |
|POLY 3             |     P=0.012 *    P<0.001 **   P<0.001 **   P=0.011 *   |P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 **   |
|POLY 1.5           |     P=0.019 *    P<0.001 **   P<0.001 **   P=0.014 *   |P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 **   |
|POLY 6             |     P=0.009 **   P<0.001 **   P<0.001 **   P=0.009 **  |P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 **   |
|LOGISTIC REGRESSION|     P=0.036 *    P<0.001 **   P<0.001 **   P=0.027 *   |P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 **   |
|COCH-ARM / FISHERS |     P=0.068      P<0.001 **   P<0.001 **   P=0.030 *   |P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 **   |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 MG/KG      37 MG/KG     75 MG/KG     150         |0 MG/KG      37 MG/KG     75 MG/KG     150          |
|                   |                                            MG/KG       |                                       MG/KG        |
|=================================================================================================================================|
|                                                                                                                                 |
|Liver                                                                                                                            |
|     Hepatocholangiocarcinoma                                                                                                    |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     0/49 (0%)    0/50 (0%)    0/50 (0%)    0/50 (0%)   |0/50 (0%)    0/50 (0%)    0/49 (0%)    2/50 (4%)    |
|POLY-3 ADJUSTED (b)|     0.0%         0.0%         0.0%         0.0%        |0.0%         0.0%         0.0%         5.7%         |
|TERMINAL (d)       |     0/38 (0%)    0/36 (0%)    0/37 (0%)    0/35 (0%)   |0/31 (0%)    0/18 (0%)    0/18 (0%)    0/2 (0%)     |
|FIRST INCIDENCE    |     ---          ---          ---          ---         |---          ---          ---          666          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     (e)          (e)          (e)          (e)         |P=0.022 *    (e)          (e)          P=0.118      |
|POLY 3             |     (e)          (e)          (e)          (e)         |P=0.039 *    (e)          (e)          P=0.187      |
|POLY 1.5           |     (e)          (e)          (e)          (e)         |P=0.042 *    (e)          (e)          P=0.210      |
|POLY 6             |     (e)          (e)          (e)          (e)         |P=0.035 *    (e)          (e)          P=0.156      |
|LOGISTIC REGRESSION|     (e)          (e)          (e)          (e)         |P=0.038 *    (e)          (e)          P=0.207      |
|COCH-ARM / FISHERS |     (e)          (e)          (e)          (e)         |P=0.046 *    (e)          (e)          P=0.247      |
|=================================================================================================================================|
       Date:  07/20/98                           EXPERIMENT: 05187 TEST: 06                                            Page 7
                     Statistical Analysis of Primary Tumors in Mice(B6C3F1)       -                   METHYLEUGENOL
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 MG/KG      37 MG/KG     75 MG/KG     150         |0 MG/KG      37 MG/KG     75 MG/KG     150          |
|                   |                                            MG/KG       |                                       MG/KG        |
|=================================================================================================================================|
|                                                                                                                                 |
|Lung                                                                                                                             |
|     Alveolar/Bronchiolar Adenoma                                                                                                |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     11/49 (22%)  10/50 (20%)  19/50 (38%)  15/50 (30%) |6/50 (12%)   4/50 (8%)    1/48 (2%)    1/45 (2%)    |
|POLY-3 ADJUSTED (b)|     24.6%        21.8%        42.5%        33.1%       |13.2%        10.1%        2.6%         3.2%         |
|TERMINAL (d)       |     9/38 (24%)   9/36 (25%)   16/37 (43%)  10/35 (29%) |3/31 (10%)   1/18 (6%)    0/18 (0%)    0/2 (0%)     |
|FIRST INCIDENCE    |     477          729          522          554         |632          562          628          681          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.092      P=0.544N     P=0.059      P=0.207     |P=0.152N     P=0.628      P=0.153N     P=0.516N     |
|POLY 3             |     P=0.120      P=0.474N     P=0.056      P=0.256     |P=0.045N*    P=0.455N     P=0.089N     P=0.140N     |
|POLY 1.5           |     P=0.121      P=0.474N     P=0.056      P=0.257     |P=0.036N*    P=0.413N     P=0.076N     P=0.105N     |
|POLY 6             |     P=0.125      P=0.484N     P=0.056      P=0.260     |P=0.062N     P=0.517N     P=0.109N     P=0.212N     |
|LOGISTIC REGRESSION|     P=0.118      P=0.454N     P=0.063      P=0.265     |P=0.030N*    P=0.360N     P=0.069N     P=0.132N     |
|COCH-ARM / FISHERS |     P=0.134      P=0.479N     P=0.071      P=0.266     |P=0.029N*    P=0.370N     P=0.062N     P=0.074N     |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 MG/KG      37 MG/KG     75 MG/KG     150         |0 MG/KG      37 MG/KG     75 MG/KG     150          |
|                   |                                            MG/KG       |                                       MG/KG        |
|=================================================================================================================================|
|                                                                                                                                 |
|Lung                                                                                                                             |
|     Alveolar/Bronchiolar Carcinoma                                                                                              |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     5/49 (10%)   4/50 (8%)    7/50 (14%)   6/50 (12%)  |1/50 (2%)    0/50 (0%)    0/48 (0%)    1/45 (2%)    |
|POLY-3 ADJUSTED (b)|     11.3%        8.7%         15.8%        13.7%       |2.2%         0.0%         0.0%         3.2%         |
|TERMINAL (d)       |     3/38 (8%)    4/36 (11%)   4/37 (11%)   4/35 (11%)  |1/31 (3%)    0/18 (0%)    0/18 (0%)    0/2 (0%)     |
|FIRST INCIDENCE    |     540          730 (T)      589          583         |731 (T)      ---          ---          676          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.314      P=0.514N     P=0.377      P=0.464     |P=0.373      P=0.608N     P=0.608N     P=0.459      |
|POLY 3             |     P=0.331      P=0.481N     P=0.377      P=0.491     |P=0.550      P=0.529N     P=0.534N     P=0.677      |
|POLY 1.5           |     P=0.341      P=0.481N     P=0.377      P=0.500     |P=0.560      P=0.515N     P=0.522N     P=0.707      |
|POLY 6             |     P=0.323      P=0.488N     P=0.379      P=0.481     |P=0.531      P=0.550N     P=0.549N     P=0.628      |
|LOGISTIC REGRESSION|     P=0.356      P=0.495N     P=0.399      P=0.517     |P=0.483      (e)          (e)          P=0.641      |
|COCH-ARM / FISHERS |     P=0.361      P=0.487N     P=0.394      P=0.514     |P=0.572      P=0.500N     P=0.510N     P=0.726      |
|=================================================================================================================================|
       Date:  07/20/98                           EXPERIMENT: 05187 TEST: 06                                            Page 8
                     Statistical Analysis of Primary Tumors in Mice(B6C3F1)       -                   METHYLEUGENOL
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 MG/KG      37 MG/KG     75 MG/KG     150         |0 MG/KG      37 MG/KG     75 MG/KG     150          |
|                   |                                            MG/KG       |                                       MG/KG        |
|=================================================================================================================================|
|                                                                                                                                 |
|Lung                                                                                                                             |
|     Alveolar/Bronchiolar Carcinoma or Alveolar/Bronchiolar                                                                      |
|     Adenoma                                                                                                                     |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     15/49 (31%)  13/50 (26%)  25/50 (50%)  20/50 (40%) |7/50 (14%)   4/50 (8%)    1/48 (2%)    2/45 (4%)    |
|POLY-3 ADJUSTED (b)|     32.8%        28.4%        54.7%        44.0%       |15.4%        10.1%        2.6%         6.3%         |
|TERMINAL (d)       |     11/38 (29%)  12/36 (33%)  19/37 (51%)  14/35 (40%) |4/31 (13%)   1/18 (6%)    0/18 (0%)    0/2 (0%)     |
|FIRST INCIDENCE    |     477          729          522          554         |632          562          628          676          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.057      P=0.457N     P=0.039 *    P=0.165     |P=0.265N     P=0.534N     P=0.108N     P=0.639      |
|POLY 3             |     P=0.063      P=0.408N     P=0.026 *    P=0.187     |P=0.071N     P=0.341N     P=0.053N     P=0.199N     |
|POLY 1.5           |     P=0.068      P=0.396N     P=0.026 *    P=0.198     |P=0.060N     P=0.301N     P=0.044N*    P=0.150N     |
|POLY 6             |     P=0.063      P=0.434N     P=0.027 *    P=0.180     |P=0.093N     P=0.403N     P=0.067N     P=0.294N     |
|LOGISTIC REGRESSION|     P=0.075      P=0.374N     P=0.035 *    P=0.220     |P=0.059N     P=0.264N     P=0.043N*    P=0.219N     |
|COCH-ARM / FISHERS |     P=0.087      P=0.387N     P=0.039 *    P=0.222     |P=0.050N     P=0.262N     P=0.034N*    P=0.107N     |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 MG/KG      37 MG/KG     75 MG/KG     150         |0 MG/KG      37 MG/KG     75 MG/KG     150          |
|                   |                                            MG/KG       |                                       MG/KG        |
|=================================================================================================================================|
|                                                                                                                                 |
|Mammary Gland                                                                                                                    |
|     Carcinoma or Adenoma                                                                                                        |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     0/50 (0%)    0/50 (0%)    0/50 (0%)    0/50 (0%)   |2/50 (4%)    0/50 (0%)    0/50 (0%)    0/50 (0%)    |
|POLY-3 ADJUSTED (b)|     0.0%         0.0%         0.0%         0.0%        |4.4%         0.0%         0.0%         0.0%         |
|TERMINAL (d)       |     0/38 (0%)    0/36 (0%)    0/37 (0%)    0/35 (0%)   |0/31 (0%)    0/18 (0%)    0/18 (0%)    0/2 (0%)     |
|FIRST INCIDENCE    |     ---          ---          ---          ---         |663          ---          ---          ---          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     (e)          (e)          (e)          (e)         |P=0.172N     P=0.348N     P=0.327N     P=0.372N     |
|POLY 3             |     (e)          (e)          (e)          (e)         |P=0.101N     P=0.274N     P=0.270N     P=0.302N     |
|POLY 1.5           |     (e)          (e)          (e)          (e)         |P=0.107N     P=0.256N     P=0.254N     P=0.269N     |
|POLY 6             |     (e)          (e)          (e)          (e)         |P=0.092N     P=0.303N     P=0.291N     P=0.358N     |
|LOGISTIC REGRESSION|     (e)          (e)          (e)          (e)         |P=0.109N     P=0.224N     P=0.224N     P=0.221N     |
|COCH-ARM / FISHERS |     (e)          (e)          (e)          (e)         |P=0.116N     P=0.247N     P=0.247N     P=0.247N     |
|=================================================================================================================================|
       Date:  07/20/98                           EXPERIMENT: 05187 TEST: 06                                            Page 9
                     Statistical Analysis of Primary Tumors in Mice(B6C3F1)       -                   METHYLEUGENOL
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 MG/KG      37 MG/KG     75 MG/KG     150         |0 MG/KG      37 MG/KG     75 MG/KG     150          |
|                   |                                            MG/KG       |                                       MG/KG        |
|=================================================================================================================================|
|                                                                                                                                 |
|Mammary Gland                                                                                                                    |
|     Fibroma, Fibroadenoma, Carcinoma, or Adenoma                                                                                |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     0/50 (0%)    0/50 (0%)    0/50 (0%)    0/50 (0%)   |2/50 (4%)    0/50 (0%)    0/50 (0%)    0/50 (0%)    |
|POLY-3 ADJUSTED (b)|     0.0%         0.0%         0.0%         0.0%        |4.4%         0.0%         0.0%         0.0%         |
|TERMINAL (d)       |     0/38 (0%)    0/36 (0%)    0/37 (0%)    0/35 (0%)   |0/31 (0%)    0/18 (0%)    0/18 (0%)    0/2 (0%)     |
|FIRST INCIDENCE    |     ---          ---          ---          ---         |663          ---          ---          ---          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     (e)          (e)          (e)          (e)         |P=0.172N     P=0.348N     P=0.327N     P=0.372N     |
|POLY 3             |     (e)          (e)          (e)          (e)         |P=0.101N     P=0.274N     P=0.270N     P=0.302N     |
|POLY 1.5           |     (e)          (e)          (e)          (e)         |P=0.107N     P=0.256N     P=0.254N     P=0.269N     |
|POLY 6             |     (e)          (e)          (e)          (e)         |P=0.092N     P=0.303N     P=0.291N     P=0.358N     |
|LOGISTIC REGRESSION|     (e)          (e)          (e)          (e)         |P=0.109N     P=0.224N     P=0.224N     P=0.221N     |
|COCH-ARM / FISHERS |     (e)          (e)          (e)          (e)         |P=0.116N     P=0.247N     P=0.247N     P=0.247N     |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 MG/KG      37 MG/KG     75 MG/KG     150         |0 MG/KG      37 MG/KG     75 MG/KG     150          |
|                   |                                            MG/KG       |                                       MG/KG        |
|=================================================================================================================================|
|                                                                                                                                 |
|Ovary                                                                                                                            |
|     Cystadenoma                                                                                                                 |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |                                                        |3/50 (6%)    0/49 (0%)    0/48 (0%)    0/41 (0%)    |
|POLY-3 ADJUSTED (b)|                                                        |6.7%         0.0%         0.0%         0.0%         |
|TERMINAL (d)       |                                                        |3/31 (10%)   0/17 (0%)    0/18 (0%)    0/2 (0%)     |
|FIRST INCIDENCE    |                                                        |731 (T)      ---          ---          ---          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |                                                        |P=0.159N     P=0.244N     P=0.231N     P=0.787N     |
|POLY 3             |                                                        |P=0.047N*    P=0.153N     P=0.153N     P=0.221N     |
|POLY 1.5           |                                                        |P=0.050N     P=0.137N     P=0.140N     P=0.188N     |
|POLY 6             |                                                        |P=0.043N*    P=0.178N     P=0.171N     P=0.279N     |
|LOGISTIC REGRESSION|                                                        |P=0.159N     (e)          (e)          (e)          |
|COCH-ARM / FISHERS |                                                        |P=0.057N     P=0.125N     P=0.129N     P=0.161N     |
|=================================================================================================================================|
       Date:  07/20/98                           EXPERIMENT: 05187 TEST: 06                                            Page 10
                     Statistical Analysis of Primary Tumors in Mice(B6C3F1)       -                   METHYLEUGENOL
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 MG/KG      37 MG/KG     75 MG/KG     150         |0 MG/KG      37 MG/KG     75 MG/KG     150          |
|                   |                                            MG/KG       |                                       MG/KG        |
|=================================================================================================================================|
|                                                                                                                                 |
|Pituitary Gland: Pars Distalis or Unspecified Site                                                                               |
|     Adenoma                                                                                                                     |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     0/45 (0%)    0/48 (0%)    0/44 (0%)    0/45 (0%)   |5/48 (10%)   1/44 (2%)    0/44 (0%)    1/40 (3%)    |
|POLY-3 ADJUSTED (b)|     0.0%         0.0%         0.0%         0.0%        |11.6%        2.9%         0.0%         3.5%         |
|TERMINAL (d)       |     0/36 (0%)    0/34 (0%)    0/34 (0%)    0/33 (0%)   |4/30 (13%)   1/18 (6%)    0/17 (0%)    0/2 (0%)     |
|FIRST INCIDENCE    |     ---          ---          ---          ---         |665          731 (T)      ---          626          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     (e)          (e)          (e)          (e)         |P=0.300N     P=0.254N     P=0.099N     P=0.714N     |
|POLY 3             |     (e)          (e)          (e)          (e)         |P=0.071N     P=0.161N     P=0.053N     P=0.225N     |
|POLY 1.5           |     (e)          (e)          (e)          (e)         |P=0.069N     P=0.141N     P=0.045N*    P=0.186N     |
|POLY 6             |     (e)          (e)          (e)          (e)         |P=0.074N     P=0.191N     P=0.064N     P=0.295N     |
|LOGISTIC REGRESSION|     (e)          (e)          (e)          (e)         |P=0.123N     P=0.202N     P=0.067N     P=0.257N     |
|COCH-ARM / FISHERS |     (e)          (e)          (e)          (e)         |P=0.070N     P=0.123N     P=0.035N*    P=0.149N     |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 MG/KG      37 MG/KG     75 MG/KG     150         |0 MG/KG      37 MG/KG     75 MG/KG     150          |
|                   |                                            MG/KG       |                                       MG/KG        |
|=================================================================================================================================|
|                                                                                                                                 |
|Skeletal Muscle                                                                                                                  |
|     Hemangiosarcoma                                                                                                             |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     1/50 (2%)    0/50 (0%)    1/50 (2%)    2/50 (4%)   |0/50 (0%)    0/50 (0%)    1/50 (2%)    0/50 (0%)    |
|POLY-3 ADJUSTED (b)|     2.3%         0.0%         2.3%         4.6%        |0.0%         0.0%         2.5%         0.0%         |
|TERMINAL (d)       |     1/38 (3%)    0/36 (0%)    1/37 (3%)    1/35 (3%)   |0/31 (0%)    0/18 (0%)    0/18 (0%)    0/2 (0%)     |
|FIRST INCIDENCE    |     730 (T)      ---          730 (T)      688         |---          ---          727          ---          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.232      P=0.511N     P=0.756      P=0.478     |P=0.483      (e)          P=0.406      (e)          |
|POLY 3             |     P=0.238      P=0.491N     P=0.759      P=0.497     |P=0.596      (e)          P=0.474      (e)          |
|POLY 1.5           |     P=0.241      P=0.494N     P=0.757      P=0.498     |P=0.645      (e)          P=0.486      (e)          |
|POLY 6             |     P=0.236      P=0.489N     P=0.760      P=0.497     |P=0.501      (e)          P=0.459      (e)          |
|LOGISTIC REGRESSION|     P=0.236      (e)          P=0.756      P=0.495     |P=0.551      (e)          P=0.427      (e)          |
|COCH-ARM / FISHERS |     P=0.246      P=0.500N     P=0.753N     P=0.500     |P=0.693      (e)          P=0.500      (e)          |
|=================================================================================================================================|
       Date:  07/20/98                           EXPERIMENT: 05187 TEST: 06                                            Page 11
                     Statistical Analysis of Primary Tumors in Mice(B6C3F1)       -                   METHYLEUGENOL
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 MG/KG      37 MG/KG     75 MG/KG     150         |0 MG/KG      37 MG/KG     75 MG/KG     150          |
|                   |                                            MG/KG       |                                       MG/KG        |
|=================================================================================================================================|
|                                                                                                                                 |
|Skin                                                                                                                             |
|     Fibrosarcoma                                                                                                                |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     0/50 (0%)    0/50 (0%)    0/50 (0%)    1/50 (2%)   |0/50 (0%)    5/50 (10%)   1/50 (2%)    0/50 (0%)    |
|POLY-3 ADJUSTED (b)|     0.0%         0.0%         0.0%         2.3%        |0.0%         12.6%        2.5%         0.0%         |
|TERMINAL (d)       |     0/38 (0%)    0/36 (0%)    0/37 (0%)    0/35 (0%)   |0/31 (0%)    2/18 (11%)   0/18 (0%)    0/2 (0%)     |
|FIRST INCIDENCE    |     ---          ---          ---          604         |---          578          484          ---          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.191      (e)          (e)          P=0.500     |P=0.474N     P=0.013 *    P=0.496      (e)          |
|POLY 3             |     P=0.196      (e)          (e)          P=0.500     |P=0.359N     P=0.021 *    P=0.478      (e)          |
|POLY 1.5           |     P=0.197      (e)          (e)          P=0.500     |P=0.295N     P=0.026 *    P=0.488      (e)          |
|POLY 6             |     P=0.195      (e)          (e)          P=0.500     |P=0.468N     P=0.017 *    P=0.464      (e)          |
|LOGISTIC REGRESSION|     P=0.203      (e)          (e)          P=0.520     |P=0.195N     P=0.037 *    P=0.472      (e)          |
|COCH-ARM / FISHERS |     P=0.198      (e)          (e)          P=0.500     |P=0.238N     P=0.028 *    P=0.500      (e)          |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 MG/KG      37 MG/KG     75 MG/KG     150         |0 MG/KG      37 MG/KG     75 MG/KG     150          |
|                   |                                            MG/KG       |                                       MG/KG        |
|=================================================================================================================================|
|                                                                                                                                 |
|Spleen                                                                                                                           |
|     Hemangiosarcoma                                                                                                             |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     2/49 (4%)    2/49 (4%)    0/50 (0%)    0/50 (0%)   |0/50 (0%)    1/50 (2%)    0/46 (0%)    0/46 (0%)    |
|POLY-3 ADJUSTED (b)|     4.6%         4.4%         0.0%         0.0%        |0.0%         2.6%         0.0%         0.0%         |
|TERMINAL (d)       |     1/38 (3%)    1/36 (3%)    0/37 (0%)    0/35 (0%)   |0/31 (0%)    1/18 (6%)    0/18 (0%)    0/2 (0%)     |
|FIRST INCIDENCE    |     570          546          ---          ---         |---          731 (T)      ---          ---          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.092N     P=0.687N     P=0.240N     P=0.251N    |P=0.823      P=0.392      (e)          (e)          |
|POLY 3             |     P=0.086N     P=0.681N     P=0.240N     P=0.240N    |P=0.604N     P=0.471      (e)          (e)          |
|POLY 1.5           |     P=0.085N     P=0.685N     P=0.239N     P=0.237N    |P=0.593N     P=0.485      (e)          (e)          |
|POLY 6             |     P=0.088N     P=0.680N     P=0.241N     P=0.244N    |P=0.614N     P=0.450      (e)          (e)          |
|LOGISTIC REGRESSION|     P=0.073N     P=0.623      P=0.215N     P=0.220N    |(e)          P=0.392      (e)          (e)          |
|COCH-ARM / FISHERS |     P=0.083N     P=0.691N     P=0.242N     P=0.242N    |P=0.579N     P=0.500      (e)          (e)          |
|=================================================================================================================================|
       Date:  07/20/98                           EXPERIMENT: 05187 TEST: 06                                            Page 12
                     Statistical Analysis of Primary Tumors in Mice(B6C3F1)       -                   METHYLEUGENOL
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 MG/KG      37 MG/KG     75 MG/KG     150         |0 MG/KG      37 MG/KG     75 MG/KG     150          |
|                   |                                            MG/KG       |                                       MG/KG        |
|=================================================================================================================================|
|                                                                                                                                 |
|Stomach, Forestomach                                                                                                             |
|     Squamous Cell Carcinoma or Papilloma Squamous                                                                               |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     0/50 (0%)    1/50 (2%)    0/50 (0%)    2/50 (4%)   |1/50 (2%)    1/50 (2%)    1/50 (2%)    0/50 (0%)    |
|POLY-3 ADJUSTED (b)|     0.0%         2.2%         0.0%         4.6%        |2.2%         2.6%         2.5%         0.0%         |
|TERMINAL (d)       |     0/38 (0%)    1/36 (3%)    0/37 (0%)    2/35 (6%)   |1/31 (3%)    0/18 (0%)    0/18 (0%)    0/2 (0%)     |
|FIRST INCIDENCE    |     ---          730 (T)      ---          730 (T)     |731 (T)      567          727          ---          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.129      P=0.489      (e)          P=0.220     |P=0.588N     P=0.691      P=0.644      P=0.967N     |
|POLY 3             |     P=0.137      P=0.509      (e)          P=0.235     |P=0.365N     P=0.730      P=0.731      P=0.551N     |
|POLY 1.5           |     P=0.138      P=0.506      (e)          P=0.236     |P=0.339N     P=0.745      P=0.745      P=0.526N     |
|POLY 6             |     P=0.136      P=0.511      (e)          P=0.233     |P=0.409N     P=0.707      P=0.712      P=0.589N     |
|LOGISTIC REGRESSION|     (e)          P=0.489      (e)          P=0.220     |P=0.325N     P=0.746N     P=0.672      (e)          |
|COCH-ARM / FISHERS |     P=0.140      P=0.500      (e)          P=0.247     |P=0.311N     P=0.753N     P=0.753N     P=0.500N     |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 MG/KG      37 MG/KG     75 MG/KG     150         |0 MG/KG      37 MG/KG     75 MG/KG     150          |
|                   |                                            MG/KG       |                                       MG/KG        |
|=================================================================================================================================|
|                                                                                                                                 |
|Stomach, Forestomach                                                                                                             |
|     Squamous Cell Papilloma                                                                                                     |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     0/50 (0%)    1/50 (2%)    0/50 (0%)    2/50 (4%)   |0/50 (0%)    1/50 (2%)    1/50 (2%)    0/50 (0%)    |
|POLY-3 ADJUSTED (b)|     0.0%         2.2%         0.0%         4.6%        |0.0%         2.6%         2.5%         0.0%         |
|TERMINAL (d)       |     0/38 (0%)    1/36 (3%)    0/37 (0%)    2/35 (6%)   |0/31 (0%)    0/18 (0%)    0/18 (0%)    0/2 (0%)     |
|FIRST INCIDENCE    |     ---          730 (T)      ---          730 (T)     |---          567          727          ---          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.129      P=0.489      (e)          P=0.220     |P=0.640      P=0.483      P=0.406      (e)          |
|POLY 3             |     P=0.137      P=0.509      (e)          P=0.235     |P=0.662N     P=0.473      P=0.474      (e)          |
|POLY 1.5           |     P=0.138      P=0.506      (e)          P=0.236     |P=0.629N     P=0.486      P=0.486      (e)          |
|POLY 6             |     P=0.136      P=0.511      (e)          P=0.233     |P=0.565      P=0.454      P=0.459      (e)          |
|LOGISTIC REGRESSION|     (e)          P=0.489      (e)          P=0.220     |P=0.573N     P=0.493      P=0.427      (e)          |
|COCH-ARM / FISHERS |     P=0.140      P=0.500      (e)          P=0.247     |P=0.594N     P=0.500      P=0.500      (e)          |
|=================================================================================================================================|
       Date:  07/20/98                           EXPERIMENT: 05187 TEST: 06                                            Page 13
                     Statistical Analysis of Primary Tumors in Mice(B6C3F1)       -                   METHYLEUGENOL
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 MG/KG      37 MG/KG     75 MG/KG     150         |0 MG/KG      37 MG/KG     75 MG/KG     150          |
|                   |                                            MG/KG       |                                       MG/KG        |
|=================================================================================================================================|
|                                                                                                                                 |
|Stomach, Glandular                                                                                                               |
|     Neuroendocrine Tumor, Malignant                                                                                             |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     0/50 (0%)    0/50 (0%)    0/50 (0%)    2/50 (4%)   |0/50 (0%)    0/50 (0%)    0/50 (0%)    0/50 (0%)    |
|POLY-3 ADJUSTED (b)|     0.0%         0.0%         0.0%         4.6%        |0.0%         0.0%         0.0%         0.0%         |
|TERMINAL (d)       |     0/38 (0%)    0/36 (0%)    0/37 (0%)    2/35 (6%)   |0/31 (0%)    0/18 (0%)    0/18 (0%)    0/2 (0%)     |
|FIRST INCIDENCE    |     ---          ---          ---          730 (T)     |---          ---          ---          ---          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.042 *    (e)          (e)          P=0.220     |(e)          (e)          (e)          (e)          |
|POLY 3             |     P=0.044 *    (e)          (e)          P=0.235     |(e)          (e)          (e)          (e)          |
|POLY 1.5           |     P=0.044 *    (e)          (e)          P=0.236     |(e)          (e)          (e)          (e)          |
|POLY 6             |     P=0.043 *    (e)          (e)          P=0.233     |(e)          (e)          (e)          (e)          |
|LOGISTIC REGRESSION|     (e)          (e)          (e)          P=0.220     |(e)          (e)          (e)          (e)          |
|COCH-ARM / FISHERS |     P=0.046 *    (e)          (e)          P=0.247     |(e)          (e)          (e)          (e)          |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 MG/KG      37 MG/KG     75 MG/KG     150         |0 MG/KG      37 MG/KG     75 MG/KG     150          |
|                   |                                            MG/KG       |                                       MG/KG        |
|=================================================================================================================================|
|                                                                                                                                 |
|Thyroid Gland: Follicular Cell                                                                                                   |
|     Adenoma                                                                                                                     |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     1/49 (2%)    0/50 (0%)    1/50 (2%)    1/50 (2%)   |2/50 (4%)    0/46 (0%)    1/46 (2%)    1/42 (2%)    |
|POLY-3 ADJUSTED (b)|     2.3%         0.0%         2.3%         2.3%        |4.4%         0.0%         2.8%         3.4%         |
|TERMINAL (d)       |     1/38 (3%)    0/36 (0%)    0/37 (0%)    1/35 (3%)   |1/31 (3%)    0/18 (0%)    1/18 (6%)    0/2 (0%)     |
|FIRST INCIDENCE    |     730 (T)      ---          630          730 (T)     |630          ---          731 (T)      692          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.523      P=0.511N     P=0.760      P=0.743     |P=0.430      P=0.340N     P=0.649N     P=0.606      |
|POLY 3             |     P=0.528      P=0.489N     P=0.759N     P=0.760     |P=0.567N     P=0.291N     P=0.577N     P=0.641N     |
|POLY 1.5           |     P=0.533      P=0.491N     P=0.760N     P=0.759N    |P=0.559N     P=0.274N     P=0.555N     P=0.603N     |
|POLY 6             |     P=0.524      P=0.489N     P=0.758N     P=0.758     |P=0.581N     P=0.317N     P=0.604N     P=0.694N     |
|LOGISTIC REGRESSION|     P=0.539      (e)          P=0.757N     P=0.743     |P=0.637N     P=0.252N     P=0.563N     P=0.613N     |
|COCH-ARM / FISHERS |     P=0.542      P=0.495N     P=0.747N     P=0.747N    |P=0.550N     P=0.269N     P=0.532N     P=0.566N     |
|=================================================================================================================================|
       Date:  07/20/98                           EXPERIMENT: 05187 TEST: 06                                            Page 14
                     Statistical Analysis of Primary Tumors in Mice(B6C3F1)       -                   METHYLEUGENOL
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 MG/KG      37 MG/KG     75 MG/KG     150         |0 MG/KG      37 MG/KG     75 MG/KG     150          |
|                   |                                            MG/KG       |                                       MG/KG        |
|=================================================================================================================================|
|                                                                                                                                 |
|Thyroid Gland: Follicular Cell                                                                                                   |
|     Carcinoma or Adenoma                                                                                                        |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     2/49 (4%)    0/50 (0%)    2/50 (4%)    1/50 (2%)   |2/50 (4%)    0/46 (0%)    1/46 (2%)    1/42 (2%)    |
|POLY-3 ADJUSTED (b)|     4.6%         0.0%         4.6%         2.3%        |4.4%         0.0%         2.8%         3.4%         |
|TERMINAL (d)       |     2/38 (5%)    0/36 (0%)    1/37 (3%)    1/35 (3%)   |1/31 (3%)    0/18 (0%)    1/18 (6%)    0/2 (0%)     |
|FIRST INCIDENCE    |     730 (T)      ---          630          730 (T)     |630          ---          731 (T)      692          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.554N     P=0.250N     P=0.688      P=0.529N    |P=0.430      P=0.340N     P=0.649N     P=0.606      |
|POLY 3             |     P=0.542N     P=0.225N     P=0.692N     P=0.501N    |P=0.567N     P=0.291N     P=0.577N     P=0.641N     |
|POLY 1.5           |     P=0.537N     P=0.228N     P=0.693N     P=0.498N    |P=0.559N     P=0.274N     P=0.555N     P=0.603N     |
|POLY 6             |     P=0.545N     P=0.225N     P=0.690N     P=0.505N    |P=0.581N     P=0.317N     P=0.604N     P=0.694N     |
|LOGISTIC REGRESSION|     P=0.538N     (e)          P=0.695N     P=0.529N    |P=0.637N     P=0.252N     P=0.563N     P=0.613N     |
|COCH-ARM / FISHERS |     P=0.527N     P=0.242N     P=0.684N     P=0.492N    |P=0.550N     P=0.269N     P=0.532N     P=0.566N     |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 MG/KG      37 MG/KG     75 MG/KG     150         |0 MG/KG      37 MG/KG     75 MG/KG     150          |
|                   |                                            MG/KG       |                                       MG/KG        |
|=================================================================================================================================|
|                                                                                                                                 |
|All Organs                                                                                                                       |
|     Hemangioma                                                                                                                  |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     0/50 (0%)    0/50 (0%)    2/50 (4%)    0/50 (0%)   |0/50 (0%)    1/50 (2%)    1/50 (2%)    0/50 (0%)    |
|POLY-3 ADJUSTED (b)|     0.0%         0.0%         4.6%         0.0%        |0.0%         2.6%         2.5%         0.0%         |
|TERMINAL (d)       |     0/38 (0%)    0/36 (0%)    2/37 (5%)    0/35 (0%)   |0/31 (0%)    0/18 (0%)    1/18 (6%)    0/2 (0%)     |
|FIRST INCIDENCE    |     ---          ---          730 (T)      ---         |---          652          731 (T)      ---          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.580      (e)          P=0.232      (e)         |P=0.604      P=0.424      P=0.392      (e)          |
|POLY 3             |     P=0.582      (e)          P=0.235      (e)         |P=0.662N     P=0.472      P=0.474      (e)          |
|POLY 1.5           |     P=0.587      (e)          P=0.234      (e)         |P=0.630N     P=0.486      P=0.486      (e)          |
|POLY 6             |     P=0.577      (e)          P=0.236      (e)         |P=0.565      P=0.453      P=0.459      (e)          |
|LOGISTIC REGRESSION|     (e)          (e)          P=0.232      (e)         |P=0.657N     P=0.515      P=0.392      (e)          |
|COCH-ARM / FISHERS |     P=0.594      (e)          P=0.247      (e)         |P=0.594N     P=0.500      P=0.500      (e)          |
|=================================================================================================================================|
       Date:  07/20/98                           EXPERIMENT: 05187 TEST: 06                                            Page 15
                     Statistical Analysis of Primary Tumors in Mice(B6C3F1)       -                   METHYLEUGENOL
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 MG/KG      37 MG/KG     75 MG/KG     150         |0 MG/KG      37 MG/KG     75 MG/KG     150          |
|                   |                                            MG/KG       |                                       MG/KG        |
|=================================================================================================================================|
|                                                                                                                                 |
|All Organs                                                                                                                       |
|     Hemangiosarcoma                                                                                                             |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     4/50 (8%)    6/50 (12%)   2/50 (4%)    6/50 (12%)  |0/50 (0%)    1/50 (2%)    2/50 (4%)    0/50 (0%)    |
|POLY-3 ADJUSTED (b)|     9.0%         12.8%        4.5%         13.8%       |0.0%         2.6%         5.1%         0.0%         |
|TERMINAL (d)       |     3/38 (8%)    4/36 (11%)   1/37 (3%)    5/35 (14%)  |0/31 (0%)    1/18 (6%)    1/18 (6%)    0/2 (0%)     |
|FIRST INCIDENCE    |     570          546          326          688         |---          731 (T)      727          ---          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.368      P=0.368      P=0.347N     P=0.328     |P=0.236      P=0.392      P=0.137      (e)          |
|POLY 3             |     P=0.383      P=0.404      P=0.337N     P=0.357     |P=0.556      P=0.471      P=0.209      (e)          |
|POLY 1.5           |     P=0.389      P=0.392      P=0.340N     P=0.362     |P=0.623      P=0.485      P=0.222      (e)          |
|POLY 6             |     P=0.376      P=0.412      P=0.336N     P=0.351     |P=0.437      P=0.450      P=0.194      (e)          |
|LOGISTIC REGRESSION|     P=0.411      P=0.337      P=0.297N     P=0.362     |P=0.317      P=0.392      P=0.152      (e)          |
|COCH-ARM / FISHERS |     P=0.402      P=0.370      P=0.339N     P=0.370     |P=0.615N     P=0.500      P=0.247      (e)          |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 MG/KG      37 MG/KG     75 MG/KG     150         |0 MG/KG      37 MG/KG     75 MG/KG     150          |
|                   |                                            MG/KG       |                                       MG/KG        |
|=================================================================================================================================|
|                                                                                                                                 |
|All Organs                                                                                                                       |
|     Hemangiosarcoma or Hemangioma                                                                                               |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     4/50 (8%)    6/50 (12%)   4/50 (8%)    6/50 (12%)  |0/50 (0%)    2/50 (4%)    3/50 (6%)    0/50 (0%)    |
|POLY-3 ADJUSTED (b)|     9.0%         12.8%        9.0%         13.8%       |0.0%         5.2%         7.6%         0.0%         |
|TERMINAL (d)       |     3/38 (8%)    4/36 (11%)   3/37 (8%)    5/35 (14%)  |0/31 (0%)    1/18 (6%)    2/18 (11%)   0/2 (0%)     |
|FIRST INCIDENCE    |     570          546          326          688         |---          652          727          ---          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.339      P=0.368      P=0.631      P=0.328     |P=0.235      P=0.145      P=0.048 *    (e)          |
|POLY 3             |     P=0.353      P=0.404      P=0.643      P=0.357     |P=0.544      P=0.207      P=0.097      (e)          |
|POLY 1.5           |     P=0.361      P=0.392      P=0.639      P=0.362     |P=0.601N     P=0.221      P=0.107      (e)          |
|POLY 6             |     P=0.344      P=0.412      P=0.643N     P=0.351     |P=0.400      P=0.188      P=0.085      (e)          |
|LOGISTIC REGRESSION|     P=0.380      P=0.337      P=0.625N     P=0.362     |P=0.492      P=0.212      P=0.055      (e)          |
|COCH-ARM / FISHERS |     P=0.376      P=0.370      P=0.643N     P=0.370     |P=0.529N     P=0.247      P=0.121      (e)          |
|=================================================================================================================================|
       Date:  07/20/98                           EXPERIMENT: 05187 TEST: 06                                            Page 16
                     Statistical Analysis of Primary Tumors in Mice(B6C3F1)       -                   METHYLEUGENOL
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 MG/KG      37 MG/KG     75 MG/KG     150         |0 MG/KG      37 MG/KG     75 MG/KG     150          |
|                   |                                            MG/KG       |                                       MG/KG        |
|=================================================================================================================================|
|                                                                                                                                 |
|All Organs                                                                                                                       |
|     Malignant Lymphoma: Histiocytic, Lymphocytic, Mixed,                                                                        |
|     NOS, or Undifferentiated Cell Type                                                                                          |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     3/50 (6%)    3/50 (6%)    8/50 (16%)   6/50 (12%)  |15/50 (30%)  8/50 (16%)   8/50 (16%)   1/50 (2%)    |
|POLY-3 ADJUSTED (b)|     6.8%         6.6%         18.0%        13.6%       |31.9%        20.1%        19.8%        2.9%         |
|TERMINAL (d)       |     2/38 (5%)    3/36 (8%)    6/37 (16%)   4/35 (11%)  |6/31 (19%)   4/18 (22%)   1/18 (6%)    0/2 (0%)     |
|FIRST INCIDENCE    |     693          730 (T)      522          543         |564          562          628          705          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.113      P=0.643      P=0.099      P=0.221     |P=0.084N     P=0.386N     P=0.348N     P=0.087N     |
|POLY 3             |     P=0.124      P=0.643N     P=0.100      P=0.243     |P<0.001N**   P=0.159N     P=0.150N     P<0.001N**   |
|POLY 1.5           |     P=0.126      P=0.649N     P=0.097      P=0.242     |P<0.001N**   P=0.113N     P=0.111N     P<0.001N**   |
|POLY 6             |     P=0.124      P=0.641N     P=0.104      P=0.244     |P=0.005N**   P=0.250N     P=0.212N     P=0.006N**   |
|LOGISTIC REGRESSION|     P=0.126      P=0.643N     P=0.097      P=0.239     |P<0.001N**   P=0.089N     P=0.090N     P<0.001N**   |
|COCH-ARM / FISHERS |     P=0.132      P=0.661N     P=0.100      P=0.243     |P<0.001N**   P=0.077N     P=0.077N     P<0.001N**   |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 MG/KG      37 MG/KG     75 MG/KG     150         |0 MG/KG      37 MG/KG     75 MG/KG     150          |
|                   |                                            MG/KG       |                                       MG/KG        |
|=================================================================================================================================|
|                                                                                                                                 |
|All Organs                                                                                                                       |
|     Benign Tumors                                                                                                               |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     33/50 (66%)  43/50 (86%)  42/50 (84%)  44/50 (88%) |29/50 (58%)  49/50 (98%)  46/50 (92%)  42/50 (84%)  |
|POLY-3 ADJUSTED (b)|     70.0%        91.1%        91.9%        92.1%       |62.3%        98.5%        94.1%        88.5%        |
|TERMINAL (d)       |     27/38 (71%)  35/36 (97%)  36/37 (97%)  32/35 (91%) |19/31 (61%)  18/18 (100%) 16/18 (89%)  1/2 (50%)    |
|FIRST INCIDENCE    |     430          614          522          512         |630          477          465          450          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.008 **   P=0.018 *    P=0.030 *    P=0.011 *   |P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 **   |
|POLY 3             |     P=0.003 **   P=0.005 **   P=0.004 **   P=0.004 **  |P=0.004 **   P<0.001 **   P<0.001 **   P=0.002 **   |
|POLY 1.5           |     P=0.003 **   P=0.009 **   P=0.007 **   P=0.004 **  |P=0.005 **   P<0.001 **   P<0.001 **   P=0.002 **   |
|POLY 6             |     P=0.004 **   P=0.003 **   P=0.003 **   P=0.005 **  |P=0.003 **   P<0.001 **   P<0.001 **   P<0.001 **   |
|LOGISTIC REGRESSION|     P=0.003 **   P=0.035 *    P=0.017 *    P=0.006 **  |P=0.007 **   P<0.001 **   P<0.001 **   P<0.001 **   |
|COCH-ARM / FISHERS |     P=0.012 *    P=0.017 *    P=0.032 *    P=0.008 **  |P=0.013 *    P<0.001 **   P<0.001 **   P=0.004 **   |
|=================================================================================================================================|
       Date:  07/20/98                           EXPERIMENT: 05187 TEST: 06                                            Page 17
                     Statistical Analysis of Primary Tumors in Mice(B6C3F1)       -                   METHYLEUGENOL
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 MG/KG      37 MG/KG     75 MG/KG     150         |0 MG/KG      37 MG/KG     75 MG/KG     150          |
|                   |                                            MG/KG       |                                       MG/KG        |
|=================================================================================================================================|
|                                                                                                                                 |
|All Organs                                                                                                                       |
|     Malignant Tumors                                                                                                            |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     23/50 (46%)  30/50 (60%)  32/50 (64%)  29/50 (58%) |27/50 (54%)  42/50 (84%)  48/50 (96%)  49/50 (98%)  |
|POLY-3 ADJUSTED (b)|     47.9%        61.4%        65.7%        61.5%       |56.0%        88.6%        97.7%        99.7%        |
|TERMINAL (d)       |     14/38 (37%)  18/36 (50%)  21/37 (57%)  18/35 (51%) |11/31 (36%)  15/18 (83%)  17/18 (94%)  2/2 (100%)   |
|FIRST INCIDENCE    |     477          546          326          543         |564          493          465          450          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.161      P=0.165      P=0.088      P=0.151     |P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 **   |
|POLY 3             |     P=0.138      P=0.127      P=0.057      P=0.129     |P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 **   |
|POLY 1.5           |     P=0.147      P=0.123      P=0.050      P=0.136     |P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 **   |
|POLY 6             |     P=0.132      P=0.131      P=0.062      P=0.125     |P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 **   |
|LOGISTIC REGRESSION|     P=0.190      P=0.086      P=0.058      P=0.162     |P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 **   |
|COCH-ARM / FISHERS |     P=0.180      P=0.115      P=0.054      P=0.158     |P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 **   |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 MG/KG      37 MG/KG     75 MG/KG     150         |0 MG/KG      37 MG/KG     75 MG/KG     150          |
|                   |                                            MG/KG       |                                       MG/KG        |
|=================================================================================================================================|
|                                                                                                                                 |
|All Organs                                                                                                                       |
|     Malignant and Benign Tumors                                                                                                 |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     41/50 (82%)  48/50 (96%)  49/50 (98%)  45/50 (90%) |41/50 (82%)  50/50 (100%) 49/50 (98%)  49/50 (98%)  |
|POLY-3 ADJUSTED (b)|     83.1%        98.3%        100.0%       93.1%       |84.4%        100.0%       99.7%        99.7%        |
|TERMINAL (d)       |     30/38 (79%)  36/36 (100%) 37/37 (100%) 32/35 (91%) |24/31 (77%)  18/18 (100%) 18/18 (100%) 2/2 (100%)   |
|FIRST INCIDENCE    |     430          546          326          512         |564          477          465          450          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.169      P=0.102      P=0.076      P=0.165     |P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 **   |
|POLY 3             |     P=0.079      P=0.008 **   P=0.003 **   P=0.108     |P<0.001 **   P=0.004 **   P=0.005 **   P=0.005 **   |
|POLY 1.5           |     P=0.098      P=0.013 *    P=0.002 **   P=0.125     |P<0.001 **   P=0.003 **   P=0.006 **   P=0.006 **   |
|POLY 6             |     P=0.077      P=0.006 **   P=0.003 **   P=0.103     |P<0.001 **   P=0.005 **   P=0.005 **   P=0.005 **   |
|LOGISTIC REGRESSION|     P=0.157      P=0.035 *    P=0.006 **   P=0.185     |P=0.002 **   P=0.002 **   P=0.004 **   P=0.003 **   |
|COCH-ARM / FISHERS |     P=0.209      P=0.026 *    P=0.008 **   P=0.194     |P=0.005 **   P<0.001 **   P=0.008 **   P=0.008 **   |
|=================================================================================================================================|

(a)  Number of tumor-bearing animals /  number of animals examined at site.
(b)  Poly-3 adjusted lifetime tumor incidence.
(d)  Observed incidence at terminal kill.
(f)  Beneath the control incidence are the P-values associated with the trend 
test.  Beneath the dosed group incidence are the P-values corresponding to 
pairwise comparisons between the controls and that dosed group.  The life
table analysis regards tumors in animals dying prior to  terminal kill as
 being (directly or indirectly) the cause of death.
Logistic regression is an alternative
 method for analyzing the incidence of non-fatal tumors. The Cochran-Armitage
and Fishers exact tests compare directly the overall incidence rates
For all tests a negative trend is indicated by N
(e)  Value of Statistic cannot be computed.
(I)  Interim sacrifice
(T)  Terminal sacrifice
#   Tumor rates based on number of animals necropsied.
*   To the right of any statistical result, indicates significance at (P<=0.05).
**  To the right of any statistical result, indicates significance at (P<=0.01).