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TDMS Study 05187-06 Pathology Tables

NTP Experiment-Test: 05187-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           METHYLEUGENOL                                       Date: 07/20/98
Route: GAVAGE                                                                                                     Time: 10:23:30

                                                           CORE STUDY




       Facility:  Battelle Columbus Laboratory

       Chemical CAS #:  93-15-2

       Lock Date:  06/12/96

       Cage Range:  All

       Reasons For Removal:    All

       Removal Date Range:     All

       Treatment Groups:       Include All




































                                                              Page   1



NTP Experiment-Test: 05187-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           METHYLEUGENOL                                       Date: 07/20/98  
Route: GAVAGE                                                                                                     Time: 10:23:30  
                                                                                                                                    

 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 7| 7| 6| 7| 6| 5| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 6| 0| 3| 3| 6| 3| 7| 7| 9| 6| 3| 3| 3| 3| 3| 3| 1| 3| 0| 3| 3| 3| 3| 3| 3|             
                                           | 5| 6| 1| 2| 5| 2| 3| 9| 5| 3| 2| 1| 1| 2| 2| 2| 7| 2| 2| 2| 2| 1| 2| 2| 2|             

 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    0 MG/KG                                | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             

 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

                                            __________________________________________________________________________|             
   Gallbladder                             | +  A  M  +  +  +  +  M  +  A  +  +  +  +  +  +  A  +  A  +  +  +  +  +  +|             

                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  A  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  A  +  +  +  +  +  +|             

                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  A  A  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +|             

                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  A  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Basophilic Focus                     |                X                          X     X                        |             
      Clear Cell Focus                     |                X                                                         |             
      Cyst                                 |                                        3                                 |             
      Eosinophilic Focus                   |                                        X  X                              |             
      Fibrosis                             |                                                                          |             
      Hematopoietic Cell Proliferation     |    2              1           1                                          |             
      Infiltration Cellular, Lymphocyte    | 1     2  2        2              1     2  1  1     1     1     1     1  1|             
      Inflammation, Chronic Active         | 1        1                    1  1     1  1        1              1     1|             
      Mineralization                       |                                                                          |             
      Mixed Cell Focus                     | X              X              X        X                                 |             
      Tension Lipidosis                    |                                              X                       X   |             
      Bile Duct, Cyst, Multiple            |                                        3                                 |             
      Bile Duct, Hyperplasia               |                                        2                                 |             
      Hepatocyte, Necrosis                 |                                                                          |             
      Hepatocyte, Vacuolization Cytoplasmic|       1        2     4     4  2        1  2           3     1        2  1|             

                                            __________________________________________________________________________|             
   Mesentery                               | +  +                                +              +  +        +         |             
      Inflammation, Chronic Active         |                                                                          |             
      Fat, Necrosis                        | 4                                                              4         |             

                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Infiltration Cellular, Lymphocyte    |       2  1                    1                    1           1         |             

                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Infiltration Cellular, Lymphocyte    | 1  1  1  1        1     1     1  1  1  1  1  2     1     1     1     1  1|             

                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperkeratosis                       |                                                                          |             
      Epithelium, Hyperplasia, Squamous    |                                                                          |             

                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  A  +  +  +  +  +  A  A  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +|             
      Ectasia                              |          1        1              1                 1     1        1     1|             
      Inflammation, Chronic Active         | 1        1  1  1  1                    1  1  1     1     2  1     1      |             
      Mineralization                       |                                                                          |             

                                            __________________________________________________________________________|             
   Tooth                                   |                         +                                                |             
      Inflammation, Chronic Active         |                                                                          |             

 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Blood Vessel                            | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Mineralization                       |                                                                          |             

 _____________________________________________________________________________________________________________________|             
NTP Experiment-Test: 05187-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           METHYLEUGENOL                                       Date: 07/20/98  
Route: GAVAGE                                                                                                     Time: 10:23:30  
                                                                                                                                    

 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 7| 7| 6| 7| 6| 5| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 6| 0| 3| 3| 6| 3| 7| 7| 9| 6| 3| 3| 3| 3| 3| 3| 1| 3| 0| 3| 3| 3| 3| 3| 3|             
                                           | 5| 6| 1| 2| 5| 2| 3| 9| 5| 3| 2| 1| 1| 2| 2| 2| 7| 2| 2| 2| 2| 1| 2| 2| 2|             

 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    0 MG/KG                                | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             

 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic Active         |                                                                          |             
      Mineralization                       |                            2                                             |             
      Atrium, Thrombosis                   |                            4                                             |             

 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Degeneration, Fatty                  |                                                                          |             
      Hematopoietic Cell Proliferation     |                                     2                                    |             
      Subcapsular, Hyperplasia             | 2  2  2  2  3  1  2  2  2     2  2  2  2  2  2  2  1  2  2  2  3  2  2  2|             

                                            __________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                               2           2        2                     |             

                                            __________________________________________________________________________|             
   Parathyroid Gland                       | M  +  +  M  +  M  +  +  M  +  +  M  +  M  M  M  +  M  +  +  +  +  +  +  M|             
      Cyst                                 |                               1                                          |             

                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Pars Distalis, Angiectasis           |                2              3           2                             2|             
      Pars Distalis, Cyst                  |                                                                          |             
      Pars Distalis, Hyperplasia           |                2                          2                       3      |             

                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Follicular Cell, Hyperplasia         |                         1              2     1     2     2               |             

 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             

 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Clitoral Gland                          | +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |             2                                                            |             
      Cyst                                 |          3     2                                   2  3           3      |             
      Mineralization                       |                                                                          |             
      Pigmentation, Hemosiderin            |             2                                                            |             

                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hydrometra                           |    3     2                 4     3  2     2     2     2           3  3   |             
      Hyperplasia, Cystic                  |          2     3  3           2  2     2           2     2  3  2  2     2|             
      Infiltration Cellular, Lymphocyte    |                               2                                          |             

 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |    3        3     3  3              2           3     3     2            |             
      Myelofibrosis                        |          1                    2                    1        1     2      |             

                                            __________________________________________________________________________|             
   Lymph Node                              |    +           +  +  +     +     +           +        +     +            |             
      Mediastinal, Hyperplasia, Lymphoid   |                                  2           3                           |             
      Renal, Ectasia                       |                   4                                                      |             

 _____________________________________________________________________________________________________________________|             
NTP Experiment-Test: 05187-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           METHYLEUGENOL                                       Date: 07/20/98  
Route: GAVAGE                                                                                                     Time: 10:23:30  
                                                                                                                                    

 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 7| 7| 6| 7| 6| 5| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 6| 0| 3| 3| 6| 3| 7| 7| 9| 6| 3| 3| 3| 3| 3| 3| 1| 3| 0| 3| 3| 3| 3| 3| 3|             
                                           | 5| 6| 1| 2| 5| 2| 3| 9| 5| 3| 2| 1| 1| 2| 2| 2| 7| 2| 2| 2| 2| 1| 2| 2| 2|             

 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    0 MG/KG                                | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             

 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +|             
      Hyperplasia, Lymphoid                |                                                                          |             
      Hyperplasia, Plasma Cell             |                                                                          |             

                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  M  +  +  +|             
      Ectasia                              |                                                    4                     |             
      Infiltration Cellular, Lymphocyte    |                                              3                           |             
      Necrosis                             |                         2                                                |             

                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Necrosis                             |                                                                          |             
      Pigmentation, Hemosiderin            |             2                                                            |             
      Lymphoid Follicle, Hyperplasia,      |                                                                          |             
          Lymphoid                         |       3                          4           2                       3   |             
      Red Pulp, Hematopoietic Cell         |                                                                          |             
          Proliferation                    | 2  3        1  2  3     4     2     3        2  4  2     2  2     2  2   |             

                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  M  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  M  +  +  +  +  +|             
      Cyst                                 | 2  1              1           2        2           2                    2|             

 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Cystic                  |                                                                          |             

                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Subcutaneous Tissue, Infiltration    |                                                                          |             
          Cellular, Lymphocyte             |                                              2                           |             
      Subcutaneous Tissue, Inflammation,   |                                                                          |             
           Chronic Active                  |                                                          3               |             

 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

                                            __________________________________________________________________________|             
   Skeletal Muscle                         |                   +                                                      |             

 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Infiltration Cellular, Lymphocyte    |                                              3                           |             
      Alveolar Epithelium, Hyperplasia     |                                                    1                     |             
      Alveolus, Infiltration Cellular,     |                                                                          |             
           Histiocyte                      |                                                                          |             

                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Suppurative            |          1                 1  1                 1                        |             
      Nasolacrimal Duct, Inflammation,     |                                                                          |             
           Suppurative                     | 2                                1                    1                  |             

                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

 _____________________________________________________________________________________________________________________|             
NTP Experiment-Test: 05187-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           METHYLEUGENOL                                       Date: 07/20/98  
Route: GAVAGE                                                                                                     Time: 10:23:30  
                                                                                                                                    

 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 7| 7| 6| 7| 6| 5| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 6| 0| 3| 3| 6| 3| 7| 7| 9| 6| 3| 3| 3| 3| 3| 3| 1| 3| 0| 3| 3| 3| 3| 3| 3|             
                                           | 5| 6| 1| 2| 5| 2| 3| 9| 5| 3| 2| 1| 1| 2| 2| 2| 7| 2| 2| 2| 2| 1| 2| 2| 2|             

 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    0 MG/KG                                | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             

 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             

 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Eye                                     | +                                                                        |             
      Hemorrhage                           |                                                                          |             
      Inflammation, Suppurative            |                                                                          |             
      Cornea, Inflammation, Chronic Active | 3                                                                        |             

                                            __________________________________________________________________________|             
   Harderian Gland                         | +                                                                 +      |             

 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Accumulation, Hyaline Droplet        |                         3                                                |             
      Infiltration Cellular, Lymphocyte    | 1     1  2  1     2           1  1     2  1  1     1     2     1  1  1   |             
      Metaplasia, Osseous                  |          1                          1                                    |             
      Mineralization                       |                                                                          |             
      Nephropathy                          |             2                                            1  1  1        1|             

                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Infiltration Cellular, Lymphocyte    | 1     1  1        2     1     1        1     3     2                 1  1|             
      Inflammation, Chronic Active         |    2                                                                     |             

 _____________________________________________________________________________________________________________________|             
NTP Experiment-Test: 05187-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           METHYLEUGENOL                                       Date: 07/20/98  
Route: GAVAGE                                                                                                     Time: 10:23:30  
                                                                                                                                    

 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 6| 6| 1| 6| 7| 7| 6| 7| 5| 7| 7| 7| 7| 7| 7| 7| 6| 7| 6| 7| 7| 7| 7|            |
                             DAY ON TEST   | 3| 2| 7| 3| 7| 1| 3| 3| 5| 1| 6| 3| 3| 3| 3| 3| 3| 3| 3| 3| 7| 3| 3| 3| 3|            |
                                           | 2| 8| 0| 2| 8| 0| 1| 2| 2| 8| 4| 2| 2| 2| 2| 2| 2| 2| 0| 2| 3| 1| 1| 2| 2|      T (*) |

 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|      A     |
    0 MG/KG                                | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |

 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |

                                            __________________________________________________________________________|____________|
   Gallbladder                             | M  A  +  +  +  +  +  +  +  +  A  +  +  M  M  +  +  +  A  +  +  +  +  +  +|  38        |

                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |

                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |

                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |

                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +|  46        |

                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  46        |

                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +|  47        |

                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Basophilic Focus                     |                                           X                          X   |      5     |
      Clear Cell Focus                     |                                                                          |      1     |
      Cyst                                 |                                                                          |      1  3.0|
      Eosinophilic Focus                   |                   X     X                 X                              |      5     |
      Fibrosis                             |          3                                                               |      1  3.0|
      Hematopoietic Cell Proliferation     |                                                 1                        |      4  1.3|
      Infiltration Cellular, Lymphocyte    |          1           1  1        1        1  1  1        1           1  1|     23  1.2|
      Inflammation, Chronic Active         | 1        1  1  1  1        2     1  1     1     1  1  1  1        1  1   |     24  1.0|
      Mineralization                       |          2                                                               |      1  2.0|
      Mixed Cell Focus                     |    X                                            X                 X      |      7     |
      Tension Lipidosis                    |                                                                          |      2     |
      Bile Duct, Cyst, Multiple            |                                                                          |      1  3.0|
      Bile Duct, Hyperplasia               |                                                                          |      1  2.0|
      Hepatocyte, Necrosis                 |       2  4        2                 1                       1            |      5  2.0|
      Hepatocyte, Vacuolization Cytoplasmic| 2  1  4     1           2        1           2                       1  1|     20  1.9|

                                            __________________________________________________________________________|____________|
   Mesentery                               |       +  +        +        +                                +     +     +|  13        |
      Inflammation, Chronic Active         |                                                                         3|      1  3.0|
      Fat, Necrosis                        |          4        4        4                                      4      |      6  4.0|

                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Infiltration Cellular, Lymphocyte    | 1                    1                          1        1        1      |     10  1.1|

                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Infiltration Cellular, Lymphocyte    | 1  1     1     1  1     1  1     1  1     1  1  1        1        1  1  1|     33  1.0|

                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperkeratosis                       |       2                                                                  |      1  2.0|
      Epithelium, Hyperplasia, Squamous    |    2                                                                     |      1  2.0|

                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  45        |
      Ectasia                              |                      1  1        1  1        1  1  1                     |     14  1.0|
      Inflammation, Chronic Active         |                1     1                    1                          1  1|     17  1.1|
      Mineralization                       |    2                                                              1      |      2  1.5|

                                            __________________________________________________________________________|____________|
   Tooth                                   |                                                             +            |   2        |

 __________________________________________________________________________________________________________________________________ 

  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
NTP Experiment-Test: 05187-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           METHYLEUGENOL                                       Date: 07/20/98  
Route: GAVAGE                                                                                                     Time: 10:23:30  
                                                                                                                                    

 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 6| 6| 1| 6| 7| 7| 6| 7| 5| 7| 7| 7| 7| 7| 7| 7| 6| 7| 6| 7| 7| 7| 7|            |
                             DAY ON TEST   | 3| 2| 7| 3| 7| 1| 3| 3| 5| 1| 6| 3| 3| 3| 3| 3| 3| 3| 3| 3| 7| 3| 3| 3| 3|            |
                                           | 2| 8| 0| 2| 8| 0| 1| 2| 2| 8| 4| 2| 2| 2| 2| 2| 2| 2| 0| 2| 3| 1| 1| 2| 2|      T (*) |

 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|      A     |
    0 MG/KG                                | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |

 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
                                           |                                                                          |            |
      Inflammation, Chronic Active         |                                                             3            |      1  3.0|

 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Blood Vessel                            | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Mineralization                       |    4                                                                     |      1  4.0|

                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inflammation, Chronic Active         |                                                          2               |      1  2.0|
      Mineralization                       |    2                                                                     |      2  2.0|
      Atrium, Thrombosis                   |                                                                          |      1  4.0|

 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Degeneration, Fatty                  |                                                       3                  |      1  3.0|
      Hematopoietic Cell Proliferation     |                   2                                                      |      2  2.0|
      Subcapsular, Hyperplasia             | 2  2     2  2  2  2  2  2  2  2  2  2  2  2  2  3  2     3  2  2  2  2  2|     47  2.0|

                                            __________________________________________________________________________|____________|
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |

                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Hyperplasia                          |       2           2  2                    2                       3      |      8  2.1|

                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +  +  +  +  M  +  +  +  +  M  M  M  +  +  +  +  +  +  +  +  +  +  +|  36        |
      Cyst                                 |                                                                          |      1  1.0|

                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +|  48        |
      Pars Distalis, Angiectasis           |                   2                                2           3         |      7  2.3|
      Pars Distalis, Cyst                  |                   2                                                      |      1  2.0|
      Pars Distalis, Hyperplasia           |       2           2                             2                        |      6  2.2|

                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Follicular Cell, Hyperplasia         |                      2           1                                   1   |      8  1.5|

 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |

 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Clitoral Gland                          | +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M|  47        |

                                            __________________________________________________________________________|____________|
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Angiectasis                          |                                                                          |      1  2.0|
      Cyst                                 |                   2  2           2              2     2           3  3   |     12  2.4|
      Mineralization                       |                                                    2                     |      1  2.0|
      Pigmentation, Hemosiderin            |                                                                          |      1  2.0|

                                            __________________________________________________________________________|____________|
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hydrometra                           | 3  3  3  3     4  2        3  2  3  3     3     4        4        2     3|     25  2.8|

 __________________________________________________________________________________________________________________________________ 

  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
NTP Experiment-Test: 05187-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           METHYLEUGENOL                                       Date: 07/20/98  
Route: GAVAGE                                                                                                     Time: 10:23:30  
                                                                                                                                    

 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 6| 6| 1| 6| 7| 7| 6| 7| 5| 7| 7| 7| 7| 7| 7| 7| 6| 7| 6| 7| 7| 7| 7|            |
                             DAY ON TEST   | 3| 2| 7| 3| 7| 1| 3| 3| 5| 1| 6| 3| 3| 3| 3| 3| 3| 3| 3| 3| 7| 3| 3| 3| 3|            |
                                           | 2| 8| 0| 2| 8| 0| 1| 2| 2| 8| 4| 2| 2| 2| 2| 2| 2| 2| 0| 2| 3| 1| 1| 2| 2|      T (*) |

 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|      A     |
    0 MG/KG                                | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |

 __________________________________________________________________________________________________________________________________ 
 GENITAL SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
      Hyperplasia, Cystic                  |          4           2     3        3                 1           3  3   |     19  2.4|
      Infiltration Cellular, Lymphocyte    |                                                                          |      1  2.0|

 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia                          |    3  3  3        2     3  2  3                       3  2  3            |     18  2.7|
      Myelofibrosis                        |                      1                                2  2        1  2   |     10  1.5|

                                            __________________________________________________________________________|____________|
   Lymph Node                              |       +  +                             +                    +            |  13        |
      Mediastinal, Hyperplasia, Lymphoid   |                                                                          |      2  2.5|
      Renal, Ectasia                       |                                                                          |      1  4.0|

                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Hyperplasia, Lymphoid                |                         3                                                |      1  3.0|
      Hyperplasia, Plasma Cell             |                         3                                                |      1  3.0|

                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  47        |
      Ectasia                              |                                                                          |      1  4.0|
      Infiltration Cellular, Lymphocyte    |                                                                          |      1  3.0|
      Necrosis                             |                                                                          |      1  2.0|

                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Necrosis                             |          2                                                               |      1  2.0|
      Pigmentation, Hemosiderin            |                                                                          |      1  2.0|
      Lymphoid Follicle, Hyperplasia,      |                                                                          |            |
          Lymphoid                         |                      3     3     3        3                              |      8  3.0|
      Red Pulp, Hematopoietic Cell         |                                                                          |            |
          Proliferation                    |    2  2  2        2     3  2     2  2  2  2              2  3     2     2|     29  2.3|

                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +  +  +  +  M  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  45        |
      Cyst                                 |          2                 1     2        2              2        1     2|     14  1.7|

 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia, Cystic                  |                         2                                                |      1  2.0|

                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Subcutaneous Tissue, Infiltration    |                                                                          |            |
          Cellular, Lymphocyte             |                                                                          |      1  2.0|
      Subcutaneous Tissue, Inflammation,   |                                                                          |            |
           Chronic Active                  |                                                                          |      1  3.0|

 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |

                                            __________________________________________________________________________|____________|
   Skeletal Muscle                         |       +                                                                  |   2        |

 __________________________________________________________________________________________________________________________________ 

  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
NTP Experiment-Test: 05187-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           METHYLEUGENOL                                       Date: 07/20/98  
Route: GAVAGE                                                                                                     Time: 10:23:30  
                                                                                                                                    

 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 6| 6| 1| 6| 7| 7| 6| 7| 5| 7| 7| 7| 7| 7| 7| 7| 6| 7| 6| 7| 7| 7| 7|            |
                             DAY ON TEST   | 3| 2| 7| 3| 7| 1| 3| 3| 5| 1| 6| 3| 3| 3| 3| 3| 3| 3| 3| 3| 7| 3| 3| 3| 3|            |
                                           | 2| 8| 0| 2| 8| 0| 1| 2| 2| 8| 4| 2| 2| 2| 2| 2| 2| 2| 0| 2| 3| 1| 1| 2| 2|      T (*) |

 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|      A     |
    0 MG/KG                                | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |

 __________________________________________________________________________________________________________________________________ 
 MUSCULOSKELETAL SYSTEM - cont             |                                                                          |            |
                                           |                                                                          |            |

 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |

 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Infiltration Cellular, Lymphocyte    |                                                                          |      1  3.0|
      Alveolar Epithelium, Hyperplasia     | 2                                                                        |      2  1.5|
      Alveolus, Infiltration Cellular,     |                                                                          |            |
           Histiocyte                      |                   2                                                      |      1  2.0|

                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inflammation, Suppurative            |          1                                         2  1     1            |      8  1.1|
      Nasolacrimal Duct, Inflammation,     |                                                                          |            |
           Suppurative                     |                                                             1            |      4  1.3|

                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |

 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Eye                                     |                   +                                                      |   2        |
      Hemorrhage                           |                   4                                                      |      1  4.0|
      Inflammation, Suppurative            |                   3                                                      |      1  3.0|
      Cornea, Inflammation, Chronic Active |                                                                          |      1  3.0|

                                            __________________________________________________________________________|____________|
   Harderian Gland                         |    +              +     +                                                |   5        |

 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Accumulation, Hyaline Droplet        |                                                                          |      1  3.0|
      Infiltration Cellular, Lymphocyte    | 1  1        1  1           1     1  1     1     1  1     1        1  1   |     28  1.1|
      Metaplasia, Osseous                  |                                                                          |      2  1.0|
      Mineralization                       |    2                                                                     |      1  2.0|
      Nephropathy                          | 1                                         1                       1  1  1|     10  1.1|

                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Infiltration Cellular, Lymphocyte    | 2              1     1  1        1        1     1                    1  1|     20  1.3|
      Inflammation, Chronic Active         |                                                          1               |      2  1.5|

 __________________________________________________________________________________________________________________________________ 

  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
NTP Experiment-Test: 05187-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           METHYLEUGENOL                                       Date: 07/20/98  
Route: GAVAGE                                                                                                     Time: 10:23:30  
                                                                                                                                    

 _____________________________________________________________________________________________________________________              
                                           | 4| 7| 6| 7| 7| 6| 7| 7| 7| 7| 6| 7| 4| 6| 7| 7| 5| 5| 7| 6| 7| 6| 7| 7| 5|             
                             DAY ON TEST   | 7| 2| 0| 3| 1| 8| 3| 3| 3| 3| 2| 3| 9| 5| 2| 3| 6| 1| 3| 7| 3| 1| 3| 3| 7|             
                                           | 7| 1| 5| 1| 9| 7| 2| 2| 2| 2| 7| 2| 3| 2| 0| 1| 2| 6| 2| 5| 2| 7| 2| 1| 8|             

 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    37 MG/KG                               | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             

 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +|             

                                            __________________________________________________________________________|             
   Gallbladder                             | A  +  +  +  A  +  +  +  +  +  A  +  +  M  A  +  +  M  M  A  +  A  +  +  +|             
      Infiltration Cellular, Lymphocyte    |                   3                                                      |             

                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic Active         |                                                                          |             
      Parasite Metazoan                    |                                                                          |             
      Epithelium, Necrosis                 |                                                                          |             

                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  A  +  +  A  A  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Suppurative            |                                                                          |             
      Ulcer                                |                                                                          |             

                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  M  +  +  +  +  +  +  +|             

                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Basophilic Focus                     |    X                                                                     |             
      Clear Cell Focus                     |                                                                          |             
      Eosinophilic Focus                   |          X        X  X     X  X     X                       X            |             
      Fibrosis                             |                                                                          |             
      Hematopoietic Cell Proliferation     |    2     1  4  1                          1                 2  3     1   |             
      Infiltration Cellular, Lymphocyte    | 1        1        2     2  1     1           2        2                  |             
      Inflammation, Chronic Active         | 1  2     1     1     1  2  2     2                 3  2     2  2     2   |             
      Mineralization                       |                                                                          |             
      Mixed Cell Focus                     |    X     X                       X                                       |             
      Pigmentation, Hemosiderin            |          2                    1              1        2  2               |             
      Bile Duct, Cyst                      |                                                                   2      |             
      Bile Duct, Hyperplasia               |                                                                          |             
      Hepatocyte, Atypia Cellular          |    2                                                                     |             
      Hepatocyte, Necrosis                 |                                     3     3                    1         |             
      Hepatocyte, Vacuolization Cytoplasmic| 2  1              2  1  2  2  1  2  2                                    |             
      Oval Cell, Hyperplasia               | 2  2  2  1  2  2  2  2  2  2  2     2     2  1  2  3  1  2  2     2  2  2|             
      Portal, Hypertrophy                  |    2  2  2     1     1                             3        2            |             

                                            __________________________________________________________________________|             
   Mesentery                               |                   +           +                 +              +        +|             
      Artery, Inflammation, Chronic Active |                                                                          |             
      Artery, Necrosis, Fibrinoid          |                                                                          |             
      Fat, Necrosis                        |                   4           4                                3         |             

                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Infiltration Cellular, Lymphocyte    |          1  2     1  1  2  2     1           2                    1      |             
      Acinus, Atrophy                      |                                                                          |             
      Artery, Inflammation, Chronic Active |                                                                          |             
      Artery, Necrosis, Fibrinoid          |                                                                          |             

                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  M  +  +  +|             
      Infiltration Cellular, Lymphocyte    | 1  1     1  1     1  2  2  2  1  2        1  2     2  2     1     2      |             

                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

 _____________________________________________________________________________________________________________________|             
NTP Experiment-Test: 05187-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           METHYLEUGENOL                                       Date: 07/20/98  
Route: GAVAGE                                                                                                     Time: 10:23:30  
                                                                                                                                    

 _____________________________________________________________________________________________________________________              
                                           | 4| 7| 6| 7| 7| 6| 7| 7| 7| 7| 6| 7| 4| 6| 7| 7| 5| 5| 7| 6| 7| 6| 7| 7| 5|             
                             DAY ON TEST   | 7| 2| 0| 3| 1| 8| 3| 3| 3| 3| 2| 3| 9| 5| 2| 3| 6| 1| 3| 7| 3| 1| 3| 3| 7|             
                                           | 7| 1| 5| 1| 9| 7| 2| 2| 2| 2| 7| 2| 3| 2| 0| 1| 2| 6| 2| 5| 2| 7| 2| 1| 8|             

 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    37 MG/KG                               | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             

 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
                                           |                                                                          |             
      Hyperkeratosis                       |    2                                                           2         |             
      Inflammation, Chronic Active         |                                                                2         |             
      Epithelium, Hyperplasia, Squamous    |                                                                2         |             
      Epithelium, Ulcer                    |                                                                4         |             

                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Ectasia                              |    1     1  1  1  1  1  1  1     1  1        1        2     1     1  1  1|             
      Hyperplasia                          |                                  1                                       |             
      Inflammation, Chronic Active         |    1     1  1  1     1  1           1        1     1  1                  |             
      Mineralization                       |                                                                          |             
      Necrosis                             |                                                                          |             
      Neuroendocrine Cell, Hyperplasia     |                                                                          |             

                                            __________________________________________________________________________|             
   Tooth                                   |                                                                          |             
      Inflammation, Chronic Active         |                                                                          |             

 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Blood Vessel                            | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic Active         |                                                                          |             

                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Mineralization                       |                                                                          |             
      Artery, Inflammation, Chronic Active |                                                                          |             
      Atrium, Thrombosis                   |    4                          3                                          |             

 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hematopoietic Cell Proliferation     |                                                 2                        |             
      Subcapsular, Hyperplasia             | 2  2  2  2  2  2  2  2  3  2  2  2  2  2  2  2  2  2  2  2  2  2  2  2  2|             

                                            __________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                                                          |             

                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                                                          |             

                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  M  +  M  +  +  +  +  +|             
      Cyst                                 |    2                                                                     |             

                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  I  +  +  +  +  +  M  +  M  +  +  +|             
      Pars Distalis, Hyperplasia           |                   1  1           2                          2        2   |             

                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +|             
      Infiltration Cellular, Lymphocyte    |                      1                                                   |             
      Inflammation, Chronic Active         |                                                                          |             
      Follicle, Cyst                       |                                                             3            |             
      Follicular Cell, Hyperplasia         |                1     2  2                    3        2           2  2   |             

 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Peritoneum                              |                                                                +         |             

 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             

 _____________________________________________________________________________________________________________________|             
NTP Experiment-Test: 05187-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           METHYLEUGENOL                                       Date: 07/20/98  
Route: GAVAGE                                                                                                     Time: 10:23:30  
                                                                                                                                    

 _____________________________________________________________________________________________________________________              
                                           | 4| 7| 6| 7| 7| 6| 7| 7| 7| 7| 6| 7| 4| 6| 7| 7| 5| 5| 7| 6| 7| 6| 7| 7| 5|             
                             DAY ON TEST   | 7| 2| 0| 3| 1| 8| 3| 3| 3| 3| 2| 3| 9| 5| 2| 3| 6| 1| 3| 7| 3| 1| 3| 3| 7|             
                                           | 7| 1| 5| 1| 9| 7| 2| 2| 2| 2| 7| 2| 3| 2| 0| 1| 2| 6| 2| 5| 2| 7| 2| 1| 8|             

 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    37 MG/KG                               | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             

 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Clitoral Gland                          | +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                                                          |             
      Infiltration Cellular, Lymphocyte    |                                                                          |             

                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                                                3         |             
      Cyst                                 |                      2  2                                            3   |             
      Infiltration Cellular, Lymphocyte    |                                                                          |             

                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hydrometra                           |       2        2  3  2     3     3        4  3     3     1  2     2     2|             
      Hyperplasia, Cystic                  | 2  1     2        2              3  2                                    |             
      Inflammation, Chronic Active         |                                                                          |             

 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          | 3  3  3  3  3  3     3  3  3  3  3  3  3  3  3  4  3  3  3  3  4  3  3  3|             
      Myelofibrosis                        |                   1              1                                   2   |             

                                            __________________________________________________________________________|             
   Lymph Node                              |                +  +                             +                    +   |             
      Lumbar, Ectasia                      |                   4                                                      |             
      Mediastinal, Necrosis                |                                                                          |             
      Pancreatic, Hyperplasia              |                                                                          |             

                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  M  +  +  +|             

                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M|             
      Angiectasis                          |                                                                          |             
      Ectasia                              |                                                                   2      |             
      Hematopoietic Cell Proliferation     |                                                       2                  |             
      Necrosis                             |                                     2                                    |             

                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoid Follicle, Depletion Cellular|                                                                          |             
      Lymphoid Follicle, Hyperplasia,      |                                                                          |             
          Lymphoid                         |                   3        2                                             |             
      Lymphoid Follicle, Necrosis          |                                     2                                    |             
      Red Pulp, Hematopoietic Cell         |                                                                          |             
          Proliferation                    | 3  3  3  3  4        2  2     3     3  4  3  3     4  3  4     4     3  4|             

                                            __________________________________________________________________________|             
   Thymus                                  | +  +  M  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |    1     1           1     2     1           1        1     2            |             
      Thymocyte, Necrosis                  |                                                                          |             

 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +|             
      Hyperplasia, Cystic                  |          2                                                               |             

                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

 _____________________________________________________________________________________________________________________|             
NTP Experiment-Test: 05187-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           METHYLEUGENOL                                       Date: 07/20/98  
Route: GAVAGE                                                                                                     Time: 10:23:30  
                                                                                                                                    

 _____________________________________________________________________________________________________________________              
                                           | 4| 7| 6| 7| 7| 6| 7| 7| 7| 7| 6| 7| 4| 6| 7| 7| 5| 5| 7| 6| 7| 6| 7| 7| 5|             
                             DAY ON TEST   | 7| 2| 0| 3| 1| 8| 3| 3| 3| 3| 2| 3| 9| 5| 2| 3| 6| 1| 3| 7| 3| 1| 3| 3| 7|             
                                           | 7| 1| 5| 1| 9| 7| 2| 2| 2| 2| 7| 2| 3| 2| 0| 1| 2| 6| 2| 5| 2| 7| 2| 1| 8|             

 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    37 MG/KG                               | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             

 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM - cont             |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Skeletal Muscle                         |          +     +     +     +              +                              |             
      Infiltration Cellular, Lymphocyte    |          2           2     2              2                              |             
      Artery, Inflammation, Chronic Active |                                                                          |             

 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +|             

                                            __________________________________________________________________________|             
   Peripheral Nerve                        |                                                                          |             
      Demyelination                        |                                                                          |             

                                            __________________________________________________________________________|             
   Spinal Cord                             |                                                                          |             
      Demyelination                        |                                                                          |             
      Artery, Inflammation, Chronic Active |                                                                          |             
      Artery, Necrosis, Fibrinoid          |                                                                          |             

 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Infiltration Cellular, Lymphocyte    |                   2                                                      |             
      Inflammation, Chronic Active         |                                                                          |             
      Alveolar Epithelium, Hyperplasia     |                                  3                                       |             
      Alveolus, Infiltration Cellular,     |                                                                          |             
           Histiocyte                      |                                  1                                       |             

                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Suppurative            |    1  1  1     1                                      1  1               |             
      Nasolacrimal Duct, Inflammation,     |                                                                          |             
           Suppurative                     |                               2                 2        1  1  2  1  1  1|             

                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +|             

 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Harderian Gland                         |                                           +  +                           |             

 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Accumulation, Hyaline Droplet        |             3                                                  3        4|             
      Infiltration Cellular, Lymphocyte    | 1  1     1  1     2  1  2  2  1  2     1     1     1  2                  |             
      Metaplasia, Osseous                  |                                                                          |             
      Mineralization                       |    1                                                                     |             
      Nephropathy                          | 1  2  2  1           1  1     1                    2  1                  |             
      Artery, Inflammation, Chronic Active |                                                                   2      |             
      Cortex, Cyst                         |    1                                                                     |             

                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Infiltration Cellular, Lymphocyte    | 2  1  1  1        1  1     2     1        1  2        1                  |             

 _____________________________________________________________________________________________________________________|             
NTP Experiment-Test: 05187-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           METHYLEUGENOL                                       Date: 07/20/98  
Route: GAVAGE                                                                                                     Time: 10:23:30  
                                                                                                                                    

 __________________________________________________________________________________________________________________________________ 
                                           | 6| 5| 6| 5| 5| 6| 7| 7| 6| 6| 7| 7| 7| 5| 6| 6| 6| 7| 7| 6| 5| 6| 6| 7| 7|            |
                             DAY ON TEST   | 0| 8| 3| 1| 6| 5| 3| 2| 0| 2| 3| 3| 3| 6| 4| 3| 6| 3| 3| 6| 9| 7| 2| 2| 3|            |
                                           | 4| 2| 2| 9| 7| 8| 2| 6| 5| 9| 2| 2| 2| 2| 9| 3| 1| 2| 2| 4| 6| 5| 0| 0| 2|      T (*) |

 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3|      A     |
    37 MG/KG                               | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |

 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |

                                            __________________________________________________________________________|____________|
   Gallbladder                             | M  M  M  +  M  A  +  +  +  M  +  +  +  A  A  A  A  +  +  A  +  A  A  +  +|  28        |
      Infiltration Cellular, Lymphocyte    |                                                                          |      1  3.0|

                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |

                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |

                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |

                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Inflammation, Chronic Active         |                                                          3               |      1  3.0|
      Parasite Metazoan                    |                                                                X         |      1     |
      Epithelium, Necrosis                 |                                                          3               |      1  3.0|

                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +|  46        |
      Inflammation, Suppurative            | 4                                                                        |      1  4.0|
      Ulcer                                | 4                                                                        |      1  4.0|

                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  A  +  +  +  +  +  +  +  +  +|  46        |

                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Basophilic Focus                     |                                                             X            |      2     |
      Clear Cell Focus                     |          X                                         X                     |      2     |
      Eosinophilic Focus                   |                   X                             X                        |      9     |
      Fibrosis                             |                   2                          1                           |      2  1.5|
      Hematopoietic Cell Proliferation     | 2  1                    2           1                       2        2   |     14  1.8|
      Infiltration Cellular, Lymphocyte    |                   2        2  2  2  1  1           1  2  2              2|     18  1.6|
      Inflammation, Chronic Active         |          2        2     1     2  1  1     2  2  1  2  1           2      |     25  1.7|
      Mineralization                       |                1                                         1               |      2  1.0|
      Mixed Cell Focus                     |                                                                          |      3     |
      Pigmentation, Hemosiderin            |                2        2           2     1                    2        1|     11  1.6|
      Bile Duct, Cyst                      |                                                                          |      1  2.0|
      Bile Duct, Hyperplasia               |                   2                                                      |      1  2.0|
      Hepatocyte, Atypia Cellular          |                                                                          |      1  2.0|
      Hepatocyte, Necrosis                 |          3        3                       2                 2  2  2      |      9  2.3|
      Hepatocyte, Vacuolization Cytoplasmic|          2     1  1                                1              2      |     14  1.6|
      Oval Cell, Hyperplasia               | 2  2  2  2     2  2  2  2  2  2  1  1  1  2  2  2  2  2  3  1  2  2  2  2|     46  1.9|
      Portal, Hypertrophy                  |                            2     3                          3            |     10  2.1|

                                            __________________________________________________________________________|____________|
   Mesentery                               |       +                                                              +   |   7        |
      Artery, Inflammation, Chronic Active |       3                                                                  |      1  3.0|
      Artery, Necrosis, Fibrinoid          |       3                                                                  |      1  3.0|
      Fat, Necrosis                        |                                                                          |      3  3.7|

                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Infiltration Cellular, Lymphocyte    |                   1           2  2                 2  1     1            |     15  1.5|
      Acinus, Atrophy                      |                                                    4                     |      1  4.0|

 __________________________________________________________________________________________________________________________________ 

  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
NTP Experiment-Test: 05187-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           METHYLEUGENOL                                       Date: 07/20/98  
Route: GAVAGE                                                                                                     Time: 10:23:30  
                                                                                                                                    

 __________________________________________________________________________________________________________________________________ 
                                           | 6| 5| 6| 5| 5| 6| 7| 7| 6| 6| 7| 7| 7| 5| 6| 6| 6| 7| 7| 6| 5| 6| 6| 7| 7|            |
                             DAY ON TEST   | 0| 8| 3| 1| 6| 5| 3| 2| 0| 2| 3| 3| 3| 6| 4| 3| 6| 3| 3| 6| 9| 7| 2| 2| 3|            |
                                           | 4| 2| 2| 9| 7| 8| 2| 6| 5| 9| 2| 2| 2| 2| 9| 3| 1| 2| 2| 4| 6| 5| 0| 0| 2|      T (*) |

 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3|      A     |
    37 MG/KG                               | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |

 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
                                           |                                                                          |            |
      Artery, Inflammation, Chronic Active |       3                                                                  |      1  3.0|
      Artery, Necrosis, Fibrinoid          |       2                                                                  |      1  2.0|

                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  M  M  +  +  +  +  +  +  +  +|  45        |
      Infiltration Cellular, Lymphocyte    | 1           1  1  2           2  2  1     1        2  1  1     1  1      |     29  1.4|

                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperkeratosis                       |                                                                      2   |      3  2.0|
      Inflammation, Chronic Active         |    2                                                                     |      2  2.0|
      Epithelium, Hyperplasia, Squamous    |    2              1                                                      |      3  1.7|
      Epithelium, Ulcer                    |    4                                                                     |      2  4.0|

                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +|  49        |
      Ectasia                              | 1     1           2  1  1  1  2  1  1        1  1  1  1  1        1  1  1|     33  1.1|
      Hyperplasia                          |                                                                          |      1  1.0|
      Inflammation, Chronic Active         | 1  1  1           1        1     1                 1  1  1  1           1|     21  1.0|
      Mineralization                       |                                                             2            |      1  2.0|
      Necrosis                             |                                                          1               |      1  1.0|
      Neuroendocrine Cell, Hyperplasia     |                                  1                                       |      1  1.0|

                                            __________________________________________________________________________|____________|
   Tooth                                   |                                                                      +   |   1        |
      Inflammation, Chronic Active         |                                                                      2   |      1  2.0|

 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Blood Vessel                            | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inflammation, Chronic Active         |       2                                                                  |      1  2.0|

                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Mineralization                       |                                                          1               |      1  1.0|
      Artery, Inflammation, Chronic Active |       3                                                                  |      1  3.0|
      Atrium, Thrombosis                   |                                                                1         |      3  2.7|

 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hematopoietic Cell Proliferation     | 2     2  1        1     1                                   2  1         |      8  1.5|
      Subcapsular, Hyperplasia             | 3  2  2  2  2     2  2  2     2  2  2  2  3  2  2  2  2  1  2  2  2  2  2|     48  2.0|

                                            __________________________________________________________________________|____________|
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia                          |                                     3                                    |      1  3.0|

                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia                          | 2  2                    3                                                |      3  2.3|

                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +  +  M  M  +  +  M  M  +  +  +  +  +  M  M  +  +  +  +  M  +  +  +|  40        |
      Cyst                                 |                                                                          |      1  2.0|

                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  I  +  +  I  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  44        |
      Pars Distalis, Hyperplasia           |                                  2                 2              2      |      8  1.8|

 __________________________________________________________________________________________________________________________________ 

  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
NTP Experiment-Test: 05187-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           METHYLEUGENOL                                       Date: 07/20/98  
Route: GAVAGE                                                                                                     Time: 10:23:30  
                                                                                                                                    

 __________________________________________________________________________________________________________________________________ 
                                           | 6| 5| 6| 5| 5| 6| 7| 7| 6| 6| 7| 7| 7| 5| 6| 6| 6| 7| 7| 6| 5| 6| 6| 7| 7|            |
                             DAY ON TEST   | 0| 8| 3| 1| 6| 5| 3| 2| 0| 2| 3| 3| 3| 6| 4| 3| 6| 3| 3| 6| 9| 7| 2| 2| 3|            |
                                           | 4| 2| 2| 9| 7| 8| 2| 6| 5| 9| 2| 2| 2| 2| 9| 3| 1| 2| 2| 4| 6| 5| 0| 0| 2|      T (*) |

 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3|      A     |
    37 MG/KG                               | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |

 __________________________________________________________________________________________________________________________________ 
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  M  M  +  +  +  +  +  +  +  +|  46        |
      Infiltration Cellular, Lymphocyte    |                                                                          |      1  1.0|
      Inflammation, Chronic Active         |                                                       1                  |      1  1.0|
      Follicle, Cyst                       |                                                                          |      1  3.0|
      Follicular Cell, Hyperplasia         |                                  1                                   1  2|     10  1.8|

 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Peritoneum                              |                                                                          |   1        |

 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Clitoral Gland                          | +  +  +  +  +  M  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  47        |
      Cyst                                 | 2                       2                                                |      2  2.0|
      Infiltration Cellular, Lymphocyte    |                                  2                                       |      1  2.0|

                                            __________________________________________________________________________|____________|
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Angiectasis                          |                                                                          |      1  3.0|
      Cyst                                 |          2                 2  2                                         4|      7  2.4|
      Infiltration Cellular, Lymphocyte    |                                  3                                       |      1  3.0|

                                            __________________________________________________________________________|____________|
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hydrometra                           |                2           3  4     2  2           4  3  3  2  2        4|     24  2.6|
      Hyperplasia, Cystic                  |       2  2                                                        2  2   |     10  2.0|
      Inflammation, Chronic Active         |             3                                                            |      1  3.0|

 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia                          | 3  3  3     3  3  3  3  3  3  3  3  3  3  3  3  3  3  3  3  3  3     4  3|     47  3.1|
      Myelofibrosis                        |                   2           1                                      1  2|      7  1.4|

                                            __________________________________________________________________________|____________|
   Lymph Node                              |                      +                                            +  +   |   7        |
      Lumbar, Ectasia                      |                                                                          |      1  4.0|
      Mediastinal, Necrosis                |                                                                   2      |      1  2.0|
      Pancreatic, Hyperplasia              |                      3                                                   |      1  3.0|

                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +  +  +  M  +  +  +  M  +  +  +  M  +  M  M  +  +  +  +  +  +  +  +|  43        |

                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Angiectasis                          |                         4                                                |      1  4.0|
      Ectasia                              |       3                                                                  |      2  2.5|
      Hematopoietic Cell Proliferation     |                                                                          |      1  2.0|
      Necrosis                             |                                                                          |      1  2.0|

                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Lymphoid Follicle, Depletion Cellular|                                              3                           |      1  3.0|
      Lymphoid Follicle, Hyperplasia,      |                                                                          |            |

 __________________________________________________________________________________________________________________________________ 

  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
NTP Experiment-Test: 05187-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           METHYLEUGENOL                                       Date: 07/20/98  
Route: GAVAGE                                                                                                     Time: 10:23:30  
                                                                                                                                    

 __________________________________________________________________________________________________________________________________ 
                                           | 6| 5| 6| 5| 5| 6| 7| 7| 6| 6| 7| 7| 7| 5| 6| 6| 6| 7| 7| 6| 5| 6| 6| 7| 7|            |
                             DAY ON TEST   | 0| 8| 3| 1| 6| 5| 3| 2| 0| 2| 3| 3| 3| 6| 4| 3| 6| 3| 3| 6| 9| 7| 2| 2| 3|            |
                                           | 4| 2| 2| 9| 7| 8| 2| 6| 5| 9| 2| 2| 2| 2| 9| 3| 1| 2| 2| 4| 6| 5| 0| 0| 2|      T (*) |

 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3|      A     |
    37 MG/KG                               | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |

 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
          Lymphoid                         |                               3                                          |      3  2.7|
      Lymphoid Follicle, Necrosis          |                                                                   2      |      2  2.0|
      Red Pulp, Hematopoietic Cell         |                                                                          |            |
          Proliferation                    | 3  3  3     2     3  3  4  3  2  2  2  4  3  2  3  2  3  4  4  4  2     2|     40  3.0|

                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  M  +  M  M  +  +  +  M|  43        |
      Cyst                                 |                                                                   1      |      9  1.2|
      Thymocyte, Necrosis                  |                                              2                    2      |      2  2.0|

 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +|  48        |
      Hyperplasia, Cystic                  |                                                                          |      1  2.0|

                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |

 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |

                                            __________________________________________________________________________|____________|
   Skeletal Muscle                         |       +           +                                +                     |   8        |
      Infiltration Cellular, Lymphocyte    |                   1                                                      |      5  1.8|
      Artery, Inflammation, Chronic Active |       3                                                                  |      1  3.0|

 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +|  47        |

                                            __________________________________________________________________________|____________|
   Peripheral Nerve                        |       +                                                                  |   1        |
      Demyelination                        |       1                                                                  |      1  1.0|

                                            __________________________________________________________________________|____________|
   Spinal Cord                             |       +                                                                  |   1        |
      Demyelination                        |       1                                                                  |      1  1.0|
      Artery, Inflammation, Chronic Active |       3                                                                  |      1  3.0|
      Artery, Necrosis, Fibrinoid          |       2                                                                  |      1  2.0|

 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Infiltration Cellular, Lymphocyte    |                                                                          |      1  2.0|
      Inflammation, Chronic Active         |                                                             2            |      1  2.0|
      Alveolar Epithelium, Hyperplasia     |                                                                          |      1  3.0|
      Alveolus, Infiltration Cellular,     |                                                                          |            |
           Histiocyte                      |                                                                          |      1  1.0|

                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inflammation, Suppurative            |       1           1  2                                         1     2   |     11  1.2|
      Nasolacrimal Duct, Inflammation,     |                                                                          |            |
           Suppurative                     | 1                    2  2  2                    1                    2  1|     15  1.5|

 __________________________________________________________________________________________________________________________________ 

  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
NTP Experiment-Test: 05187-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           METHYLEUGENOL                                       Date: 07/20/98  
Route: GAVAGE                                                                                                     Time: 10:23:30  
                                                                                                                                    

 __________________________________________________________________________________________________________________________________ 
                                           | 6| 5| 6| 5| 5| 6| 7| 7| 6| 6| 7| 7| 7| 5| 6| 6| 6| 7| 7| 6| 5| 6| 6| 7| 7|            |
                             DAY ON TEST   | 0| 8| 3| 1| 6| 5| 3| 2| 0| 2| 3| 3| 3| 6| 4| 3| 6| 3| 3| 6| 9| 7| 2| 2| 3|            |
                                           | 4| 2| 2| 9| 7| 8| 2| 6| 5| 9| 2| 2| 2| 2| 9| 3| 1| 2| 2| 4| 6| 5| 0| 0| 2|      T (*) |

 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3|      A     |
    37 MG/KG                               | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |

 __________________________________________________________________________________________________________________________________ 
 RESPIRATORY SYSTEM - cont                 |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |

 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Harderian Gland                         |                                                                          |   2        |

 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Accumulation, Hyaline Droplet        |                                                                          |      3  3.3|
      Infiltration Cellular, Lymphocyte    | 1     1  1        2           1  2     1     1  1  2  1  1  1  1        2|     29  1.3|
      Metaplasia, Osseous                  |                2                                                         |      1  2.0|
      Mineralization                       |                3           2                                             |      3  2.0|
      Nephropathy                          |                   1  1              1                    1               |     13  1.2|
      Artery, Inflammation, Chronic Active |       3                                                                  |      2  2.5|
      Cortex, Cyst                         |                                                                          |      1  1.0|

                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +|  49        |
      Infiltration Cellular, Lymphocyte    | 2  1     1     1  2     1  1  2  1  2  2     1     1  1  1  1  1        1|     29  1.3|

 __________________________________________________________________________________________________________________________________ 

  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
NTP Experiment-Test: 05187-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           METHYLEUGENOL                                       Date: 07/20/98  
Route: GAVAGE                                                                                                     Time: 10:23:30  
                                                                                                                                    

 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 5| 7| 6| 6| 6| 5| 6| 6| 7| 5| 6| 4| 5| 7| 7| 5| 6| 5| 6| 7| 6| 7| 7|             
                             DAY ON TEST   | 3| 3| 2| 2| 5| 5| 3| 4| 9| 5| 3| 2| 1| 8| 8| 3| 3| 9| 9| 9| 9| 1| 4| 3| 3|             
                                           | 1| 3| 1| 8| 8| 9| 7| 5| 0| 2| 1| 0| 1| 9| 2| 2| 2| 0| 4| 7| 4| 7| 1| 2| 2|             

 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    75 MG/KG                               | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             

 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

                                            __________________________________________________________________________|             
   Gallbladder                             | +  +  +  +  +  +  A  A  +  +  +  A  A  M  A  +  +  +  A  M  A  M  +  +  +|             

                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  A  +  +  +|             

                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +|             

                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  A  +  A  +  +  +  +  +  +  A  +  +  +  +  +  +  +  A  +  +  +|             

                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  M  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +|             
      Ulcer                                |                                           4                              |             

                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  A  +  +  +  +  M  A  +  +  +  +  +  A  +  +  +  A  +  +  +  A  +  +  +|             

                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  A  +  +  A  +  A  +  +  +  +  +  A  A  +  +  +  +  +  +  +  A  +  +  +|             

                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                                                                          |             
      Eosinophilic Focus                   |                                                    X     X              X|             
      Fibrosis                             |       3                                                                  |             
      Hematopoietic Cell Proliferation     | 2     1     1  2        3  2                 2  1  1        2     1  1  1|             
      Infiltration Cellular, Lymphocyte    | 2              2                 2  2        2  2  2     2  1  1        1|             
      Inflammation, Chronic Active         |       2     2                 2     2        2  2  1        2           2|             
      Pigmentation, Hemosiderin            |          1     2              2              2  1        1  2        1  2|             
      Bile Duct, Cyst                      |          2                                   2                          2|             
      Bile Duct, Hyperplasia               | 2  1                                         1           2              1|             
      Hepatocyte, Necrosis                 |       4        1     2  3                 3     1           3            |             
      Hepatocyte, Vacuolization Cytoplasmic| 1     1     1  2     1                    1        1     2  1            |             
      Oval Cell, Hyperplasia               |    2  2  2  2  2     2        1  2  2     2     1  2     2  2  2  2     2|             
      Portal, Hypertrophy                  |          2     2           2                                             |             

                                            __________________________________________________________________________|             
   Mesentery                               |                +                                                  +      |             
      Fat, Necrosis                        |                                                                   4      |             

                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  A  +  +  +|             
      Infiltration Cellular, Lymphocyte    |       1              1        1  2  1        2        1     1           2|             

                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  M  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  M  M  +  +  +|             
      Infiltration Cellular, Lymphocyte    |       2        1     1     1     2  1     1        2  1  1              1|             

                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +|             
      Diverticulum                         |                                                                          |             
      Inflammation, Chronic Active         |                                                       2                  |             
      Epithelium, Hyperplasia, Squamous    |                                                       3                  |             

                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                         2     1                 1           2     2      |             
      Ectasia                              | 1  1     2     2        1  1  2           2  1  1           1     1  1  2|             
      Hyperplasia                          |                                              1  2                       2|             
      Inflammation, Chronic Active         | 1                       1                    1  1                       1|             
      Mineralization                       |                   1                                1                     |             
      Necrosis                             |                                           2                              |             

 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Blood Vessel                            | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +|             

                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +|             

 _____________________________________________________________________________________________________________________|             
NTP Experiment-Test: 05187-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           METHYLEUGENOL                                       Date: 07/20/98  
Route: GAVAGE                                                                                                     Time: 10:23:30  
                                                                                                                                    

 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 5| 7| 6| 6| 6| 5| 6| 6| 7| 5| 6| 4| 5| 7| 7| 5| 6| 5| 6| 7| 6| 7| 7|             
                             DAY ON TEST   | 3| 3| 2| 2| 5| 5| 3| 4| 9| 5| 3| 2| 1| 8| 8| 3| 3| 9| 9| 9| 9| 1| 4| 3| 3|             
                                           | 1| 3| 1| 8| 8| 9| 7| 5| 0| 2| 1| 0| 1| 9| 2| 2| 2| 0| 4| 7| 4| 7| 1| 2| 2|             

 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    75 MG/KG                               | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             

 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |             
                                           |                                                                          |             
      Mineralization                       |                                           3                              |             
      Atrium, Thrombosis                   |          4  3              4              3                              |             

 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hematopoietic Cell Proliferation     |    1                    3     1              1              1           1|             
      Subcapsular, Hyperplasia             | 1  2  2  2  1  2  2  2  2  1  2  2  2  2  2  2  2  2  2  2  2  1  2  2  2|             

                                            __________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                2                             3                           |             

                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  A  +  +  +|             
      Hyperplasia                          |                                                                          |             

                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  M  M  +  M  +  +  +  +  +  +  +  M  +  +  +  +  +  +  M  M  +  +|             

                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  M  +  +  +  +  +  +  M  +  +  +  +  +  +  M  M  +  +  +|             
      Pars Distalis, Cyst                  |                                                                          |             
      Pars Distalis, Hyperplasia           |                                                                          |             

                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  M  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +|             
      Follicle, Cyst                       |                                                                          |             
      Follicular Cell, Hyperplasia         | 2                                            2  1                        |             

 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             

 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Clitoral Gland                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  M  +|             

                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +|             
      Cyst                                 |       3        2                                                  2  4   |             
      Infiltration Cellular, Lymphocyte    |                                                                          |             

                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +|             
      Hydrometra                           |       3     1     3  2  3                                   2     2      |             
      Infiltration Cellular, Lymphocyte    |                                                                          |             

 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          | 3  3  3  3  3        3  4  3  3  3  3     3  3  3  3  3  4  4  3  3  3  3|             
      Myelofibrosis                        |                   2                             1                        |             

                                            __________________________________________________________________________|             
   Lymph Node                              |                         +                    +              +            |             

                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  M  +  M  +  +  +  +  +  +  +  +  M  +  +  +  +  M  M  +  +  +|             

                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  M  +  +  +  +  +  +  +  M  +  +  +  A  +  +  +  +  +  +  +  M  +  +  +|             
      Angiectasis                          |                                                                          |             
      Ectasia                              |                                                                          |             
      Hematopoietic Cell Proliferation     | 2                                                                        |             

                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  M  +  +  +  +  +  +  A  +  +  +  +  +  +  +  M  +  +  +|             
      Fibrosis                             |                4                                                         |             
      Lymphoid Follicle, Hyperplasia,      |                                                                          |             

 _____________________________________________________________________________________________________________________|             
NTP Experiment-Test: 05187-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           METHYLEUGENOL                                       Date: 07/20/98  
Route: GAVAGE                                                                                                     Time: 10:23:30  
                                                                                                                                    

 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 5| 7| 6| 6| 6| 5| 6| 6| 7| 5| 6| 4| 5| 7| 7| 5| 6| 5| 6| 7| 6| 7| 7|             
                             DAY ON TEST   | 3| 3| 2| 2| 5| 5| 3| 4| 9| 5| 3| 2| 1| 8| 8| 3| 3| 9| 9| 9| 9| 1| 4| 3| 3|             
                                           | 1| 3| 1| 8| 8| 9| 7| 5| 0| 2| 1| 0| 1| 9| 2| 2| 2| 0| 4| 7| 4| 7| 1| 2| 2|             

 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    75 MG/KG                               | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             

 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
          Lymphoid                         |                                                                          |             
      Lymphoid Follicle, Necrosis          |                                  2                 1  2                  |             
      Red Pulp, Hematopoietic Cell         |                                                                          |             
          Proliferation                    | 3  4  3  3  3  2     3  3  3  3  3  3     4  3  3  3  2  3        4  3  3|             

                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  M  M  M  +  +  +  +  +  +  +  M  +  +  +  +  +  +  M  +  +  +|             
      Cyst                                 |       2                                                           1      |             
      Thymocyte, Necrosis                  |                                  3                 2                     |             

 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Subcutaneous Tissue, Infiltration    |                                                                          |             
          Cellular, Lymphocyte             |                                                                          |             

 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

                                            __________________________________________________________________________|             
   Skeletal Muscle                         |                                                                          |             
      Infiltration Cellular, Lymphocyte    |                                                                          |             

 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  M  M  +  +  +|             

 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +|             
      Alveolus, Infiltration Cellular,     |                                                                          |             
           Histiocyte                      |                            4                                             |             
      Bronchiole, Exudate, Organized       |             3                                                            |             
      Mediastinum, Inflammation, Chronic   |                                                                          |             
          Active                           |                                                                          |             
      Mediastinum, Necrosis                |                                                                          |             

                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Suppurative            |    1  2     1  1  1        2  1           1     1                 1      |             
      Nasolacrimal Duct, Inflammation,     |                                                                          |             
           Suppurative                     |          2        2                                         1  1     1  1|             

                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  M  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Eye                                     |                                                                          |             
      Atrophy                              |                                                                          |             

                                            __________________________________________________________________________|             
   Harderian Gland                         |          +     +                                                         |             
      Inflammation, Suppurative            |                4                                                         |             

 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

 _____________________________________________________________________________________________________________________|             
NTP Experiment-Test: 05187-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           METHYLEUGENOL                                       Date: 07/20/98  
Route: GAVAGE                                                                                                     Time: 10:23:30  
                                                                                                                                    

 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 5| 7| 6| 6| 6| 5| 6| 6| 7| 5| 6| 4| 5| 7| 7| 5| 6| 5| 6| 7| 6| 7| 7|             
                             DAY ON TEST   | 3| 3| 2| 2| 5| 5| 3| 4| 9| 5| 3| 2| 1| 8| 8| 3| 3| 9| 9| 9| 9| 1| 4| 3| 3|             
                                           | 1| 3| 1| 8| 8| 9| 7| 5| 0| 2| 1| 0| 1| 9| 2| 2| 2| 0| 4| 7| 4| 7| 1| 2| 2|             

 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    75 MG/KG                               | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             

 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
      Infiltration Cellular, Lymphocyte    | 1  1     1     1  2  1        1  1  1  2     1  2  2     1        1     1|             
      Mineralization                       |                                           2                              |             
      Necrosis                             |                                                                          |             
      Nephropathy                          | 1              2              1                                          |             
      Renal Tubule, Hyperplasia            |                                                          2               |             
      Renal Tubule, Pigmentation,          |                                                                          |             
          Hemosiderin                      |                                                                          |             

                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +|             
      Infiltration Cellular, Lymphocyte    | 1     1        1  1  1        1     2  1  1     1  2  1              1   |             

 _____________________________________________________________________________________________________________________|             
NTP Experiment-Test: 05187-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           METHYLEUGENOL                                       Date: 07/20/98  
Route: GAVAGE                                                                                                     Time: 10:23:30  
                                                                                                                                    

 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 6| 7| 7| 6| 4| 7| 6| 6| 6| 7| 7| 4| 7| 3| 7| 7| 7| 7| 7| 7|            |
                             DAY ON TEST   | 0| 3| 3| 3| 2| 6| 2| 3| 1| 6| 3| 9| 5| 2| 3| 3| 8| 3| 7| 3| 2| 3| 1| 3| 3|            |
                                           | 4| 2| 2| 2| 0| 1| 7| 2| 9| 5| 2| 8| 9| 8| 2| 2| 4| 2| 1| 2| 2| 1| 4| 1| 2|      T (*) |

 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|      A     |
    75 MG/KG                               | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |

 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |

                                            __________________________________________________________________________|____________|
   Gallbladder                             | A  +  +  +  A  A  A  +  +  +  +  +  +  A  +  A  +  +  A  +  M  +  A  M  +|  30        |

                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |

                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |

                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +|  45        |

                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +|  46        |
      Ulcer                                |                                                                          |      1  4.0|

                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  +  A  +  +  +  +  A  +  +  +  +  +  +  A  +  +  +  A  +  +|  40        |

                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +|  42        |

                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +|  49        |
      Atrophy                              |                                                    2                     |      1  2.0|
      Eosinophilic Focus                   |                                     X                                    |      4     |
      Fibrosis                             |                                  2  2                                    |      3  2.3|
      Hematopoietic Cell Proliferation     |    1     2              3        1  1     2     1        2  3           2|     23  1.7|
      Infiltration Cellular, Lymphocyte    |    2  1  2     1           2                    2  2     2        2     2|     21  1.8|
      Inflammation, Chronic Active         |    2  1        2  2              2        2  2                           |     16  1.9|
      Pigmentation, Hemosiderin            |    2     2  2  2  2  1  3     2     2        2  2  2        2  2  2      |     24  1.8|
      Bile Duct, Cyst                      |                   4  4                                            3      |      6  2.8|
      Bile Duct, Hyperplasia               | 2        2     2              1     2     1                              |     11  1.5|
      Hepatocyte, Necrosis                 |             3  2  3  1  2  3     1                          2           2|     16  2.3|
      Hepatocyte, Vacuolization Cytoplasmic|                            1                             1               |     11  1.2|
      Oval Cell, Hyperplasia               | 2        2  2  2     1  2  2  2  2  2  2  2  2  2        1  2  2  1     2|     36  1.9|
      Portal, Hypertrophy                  |                            3  3     2           2                        |      7  2.3|

                                            __________________________________________________________________________|____________|
   Mesentery                               |                                                 +                        |   3        |
      Fat, Necrosis                        |                                                                          |      1  4.0|

                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  A  +  +  +  +  +  +|  46        |
      Infiltration Cellular, Lymphocyte    |          2                    1                          2              2|     13  1.5|

                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  M  +  M  +  +  +  +  +  +  +  +  +  +  +|  44        |
      Infiltration Cellular, Lymphocyte    | 1  1     1     1     1  1     1     1     1  1  1     1  1  1     1     1|     27  1.1|

                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +|  48        |
      Diverticulum                         |                               X                                          |      1     |
      Inflammation, Chronic Active         |                                                                          |      1  2.0|
      Epithelium, Hyperplasia, Squamous    |                                           2                              |      2  2.5|

                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  A  +  +  +  +  +  +  A  +  +  +  +  A  +  +  +  +  +  +|  46        |
      Atrophy                              |       2  1              1                          2           2         |     10  1.6|
      Ectasia                              | 1  1  1  2           1  1  1  2     1     1     1  2     1  2  1     1  2|     31  1.3|
      Hyperplasia                          |                      2                                                  1|      5  1.6|
      Inflammation, Chronic Active         |       1              1     1        1     1                          1  1|     12  1.0|
      Mineralization                       |                                                                          |      2  1.0|

 __________________________________________________________________________________________________________________________________ 

  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
NTP Experiment-Test: 05187-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           METHYLEUGENOL                                       Date: 07/20/98  
Route: GAVAGE                                                                                                     Time: 10:23:30  
                                                                                                                                    

 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 6| 7| 7| 6| 4| 7| 6| 6| 6| 7| 7| 4| 7| 3| 7| 7| 7| 7| 7| 7|            |
                             DAY ON TEST   | 0| 3| 3| 3| 2| 6| 2| 3| 1| 6| 3| 9| 5| 2| 3| 3| 8| 3| 7| 3| 2| 3| 1| 3| 3|            |
                                           | 4| 2| 2| 2| 0| 1| 7| 2| 9| 5| 2| 8| 9| 8| 2| 2| 4| 2| 1| 2| 2| 1| 4| 1| 2|      T (*) |

 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|      A     |
    75 MG/KG                               | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |

 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
                                           |                                                                          |            |
      Necrosis                             |                         1                                         3      |      3  2.0|

 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Blood Vessel                            | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |

                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Mineralization                       |                                                                          |      1  3.0|
      Atrium, Thrombosis                   |                      3        3                                          |      6  3.3|

 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hematopoietic Cell Proliferation     |       2           2     2        1  1        1     1        1     1  2  1|     17  1.4|
      Subcapsular, Hyperplasia             | 2  2  2  2  1  2  2  2  2  2  1  1  2  2  2  1  3  2     2  2  2  1  2  2|     49  1.8|

                                            __________________________________________________________________________|____________|
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia                          |                1     2              2        1                          1|      7  1.7|

                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  A  +  +  +  +  +  +|  46        |
      Hyperplasia                          |                      2                                                   |      1  2.0|

                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +  +  +  M  +  +  +  +  +  M  M  +  +  M  +  M  M  +  +  +  +  +  +|  38        |

                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  M  +  +  +  +  +  +  +|  44        |
      Pars Distalis, Cyst                  |                1                                                         |      1  1.0|
      Pars Distalis, Hyperplasia           |    2              2                 3                                    |      3  2.3|

                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +|  46        |
      Follicle, Cyst                       |                      2                                                   |      1  2.0|
      Follicular Cell, Hyperplasia         |       1              2                    2              2               |      7  1.7|

 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |

 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Clitoral Gland                          | +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  M  +  +  +  +  +  +  +  +|  46        |

                                            __________________________________________________________________________|____________|
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Cyst                                 |    2                                   2                    2            |      7  2.4|
      Infiltration Cellular, Lymphocyte    |    3                                                                     |      1  3.0|

                                            __________________________________________________________________________|____________|
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Hydrometra                           |       3     2  2  1                 2     2  2                          3|     15  2.2|
      Infiltration Cellular, Lymphocyte    |    3                                                                     |      1  3.0|

 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +|  48        |
      Hyperplasia                          | 4  3  3  3  3  3  3  3  4  3  3  3  2  2  3  3  3  3     3  3  3  3  2  3|     46  3.0|

 __________________________________________________________________________________________________________________________________ 

  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
NTP Experiment-Test: 05187-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           METHYLEUGENOL                                       Date: 07/20/98  
Route: GAVAGE                                                                                                     Time: 10:23:30  
                                                                                                                                    

 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 6| 7| 7| 6| 4| 7| 6| 6| 6| 7| 7| 4| 7| 3| 7| 7| 7| 7| 7| 7|            |
                             DAY ON TEST   | 0| 3| 3| 3| 2| 6| 2| 3| 1| 6| 3| 9| 5| 2| 3| 3| 8| 3| 7| 3| 2| 3| 1| 3| 3|            |
                                           | 4| 2| 2| 2| 0| 1| 7| 2| 9| 5| 2| 8| 9| 8| 2| 2| 4| 2| 1| 2| 2| 1| 4| 1| 2|      T (*) |

 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|      A     |
    75 MG/KG                               | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |

 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
      Myelofibrosis                        |    1                                                                     |      3  1.3|

                                            __________________________________________________________________________|____________|
   Lymph Node                              | +           +                          +        +           +            |   8        |

                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  M  +  +  M  M  M  +  +  +  +  +  +  +  +  +  +  +|  41        |

                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  A  +  +  M  +  +  +|  43        |
      Angiectasis                          |                4                                                         |      1  4.0|
      Ectasia                              |                                                                      3   |      1  3.0|
      Hematopoietic Cell Proliferation     |                                                                          |      1  2.0|

                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +|  46        |
      Fibrosis                             |                                                                          |      1  4.0|
      Lymphoid Follicle, Hyperplasia,      |                                                                          |            |
          Lymphoid                         |    3                                                     2               |      2  2.5|
      Lymphoid Follicle, Necrosis          |                            2                                             |      4  1.8|
      Red Pulp, Hematopoietic Cell         |                                                                          |            |
          Proliferation                    | 3  3  4  3  3  4  3  3  4  3  3  3  3  4  3  3  4  4     2  2  3  4  4  3|     45  3.2|

                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +  M  M  +  +  +  +  M  +  +  +  M  +  +  +  +  M  +  +  +  +  +  +  +|  40        |
      Cyst                                 |    1           1                                                        1|      5  1.2|
      Thymocyte, Necrosis                  |                            3                                             |      3  2.7|

 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |

                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Subcutaneous Tissue, Infiltration    |                                                                          |            |
          Cellular, Lymphocyte             |    2                                                                    1|      2  1.5|

 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |

                                            __________________________________________________________________________|____________|
   Skeletal Muscle                         |             +     +                                                     +|   3        |
      Infiltration Cellular, Lymphocyte    |                                                                         2|      1  2.0|

 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +|  46        |

 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Alveolus, Infiltration Cellular,     |                                                                          |            |
           Histiocyte                      |                                                    2                     |      2  3.0|
      Bronchiole, Exudate, Organized       |                                                                          |      1  3.0|
      Mediastinum, Inflammation, Chronic   |                                                                          |            |
          Active                           |                                                       3                  |      1  3.0|

 __________________________________________________________________________________________________________________________________ 

  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
NTP Experiment-Test: 05187-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           METHYLEUGENOL                                       Date: 07/20/98  
Route: GAVAGE                                                                                                     Time: 10:23:30  
                                                                                                                                    

 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 6| 7| 7| 6| 4| 7| 6| 6| 6| 7| 7| 4| 7| 3| 7| 7| 7| 7| 7| 7|            |
                             DAY ON TEST   | 0| 3| 3| 3| 2| 6| 2| 3| 1| 6| 3| 9| 5| 2| 3| 3| 8| 3| 7| 3| 2| 3| 1| 3| 3|            |
                                           | 4| 2| 2| 2| 0| 1| 7| 2| 9| 5| 2| 8| 9| 8| 2| 2| 4| 2| 1| 2| 2| 1| 4| 1| 2|      T (*) |

 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|      A     |
    75 MG/KG                               | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |

 __________________________________________________________________________________________________________________________________ 
 RESPIRATORY SYSTEM - cont                 |                                                                          |            |
                                           |                                                                          |            |
      Mediastinum, Necrosis                |                               3                                          |      1  3.0|

                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  I  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Inflammation, Suppurative            |                         2                       1              1         |     13  1.2|
      Nasolacrimal Duct, Inflammation,     |                                                                          |            |
           Suppurative                     |       1                       1                    3        2     2      |     11  1.5|

                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +|  47        |

 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Eye                                     |                                                    +                     |   1        |
      Atrophy                              |                                                    4                     |      1  4.0|

                                            __________________________________________________________________________|____________|
   Harderian Gland                         |                                                                          |   2        |
      Inflammation, Suppurative            |                                                                          |      1  4.0|

 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Infiltration Cellular, Lymphocyte    |    1  1  1     1  1        2     1  1     1              1        1  1  1|     29  1.2|
      Mineralization                       |                   2                                                      |      2  2.0|
      Necrosis                             |                                                             3            |      1  3.0|
      Nephropathy                          |                   1        2  1     1              3           2         |      9  1.6|
      Renal Tubule, Hyperplasia            |                                                                          |      1  2.0|
      Renal Tubule, Pigmentation,          |                                                                          |            |
          Hemosiderin                      | 3                                                  4                     |      2  3.5|

                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +|  47        |
      Infiltration Cellular, Lymphocyte    |    1     1     1     1  1  1  1           1     1  1     1        2  1  1|     27  1.1|

 __________________________________________________________________________________________________________________________________ 

  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
NTP Experiment-Test: 05187-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           METHYLEUGENOL                                       Date: 07/20/98  
Route: GAVAGE                                                                                                     Time: 10:23:30  
                                                                                                                                    

 _____________________________________________________________________________________________________________________              
                                           | 5| 5| 6| 5| 6| 5| 6| 6| 7| 7| 5| 6| 6| 6| 6| 6| 6| 7| 5| 6| 6| 7| 6| 6| 7|             
                             DAY ON TEST   | 9| 1| 2| 0| 8| 3| 6| 8| 2| 1| 8| 5| 2| 5| 5| 3| 1| 1| 7| 2| 7| 3| 8| 8| 3|             
                                           | 6| 8| 4| 5| 6| 7| 2| 0| 3| 7| 8| 2| 6| 9| 4| 4| 5| 7| 7| 6| 9| 1| 7| 6| 0|             

 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    150                                    | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|             
    MG/KG                                  | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             

 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  M  M  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

                                            __________________________________________________________________________|             
   Gallbladder                             | M  +  A  +  +  A  A  +  A  +  A  +  +  A  +  +  A  +  A  +  A  +  +  A  M|             

                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  A  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  A  +  M  +  +  A  +  +  +  M  +  +  +  +  +  +  +  +  +  +|             

                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  A  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  A|             

                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  A  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Basophilic Focus                     |                                  X                                      X|             
      Clear Cell Focus                     |                                              X                           |             
      Eosinophilic Focus                   |    X                             X           X                 X         |             
      Hematopoietic Cell Proliferation     |          1     1     2     2        2     2  2  2  2  2     2  2  2  1   |             
      Infiltration Cellular, Lymphocyte    |          2  2        2  1                    2        1        1     2   |             
      Inflammation, Chronic Active         |    2     2     2                                4                 1      |             
      Inflammation, Suppurative            | 4                                                                        |             
      Pigmentation, Hemosiderin            |       1  1  2     2     1           1  1     2           2     2  2  2   |             
      Bile Duct, Cyst                      |                      3  2                                                |             
      Bile Duct, Hyperplasia               | 2  2                             2                             2         |             
      Hepatocyte, Hyperplasia, Adenomatous |                                                                          |             
      Hepatocyte, Necrosis                 |       3        1                    2           2                 1  2   |             
      Hepatocyte, Vacuolization Cytoplasmic|    2        2  2     2           2  1                 1                 1|             
      Hepatocyte, Centrilobular, Atrophy   |                                                                          |             
      Oval Cell, Hyperplasia               |    2  2  2     2  2  2  1        2  2  1  2  2  2     2  2  2  1  3  2  2|             
      Portal, Hypertrophy                  |    2                             3           3           3  3  3  3     3|             

                                            __________________________________________________________________________|             
   Mesentery                               | +                             +                                          |             
      Inflammation, Suppurative            | 4                                                                        |             
      Fat, Necrosis                        |                               4                                          |             

                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Infiltration Cellular, Lymphocyte    |          2                                         1                     |             

                                            __________________________________________________________________________|             
   Salivary Glands                         | M  +  M  +  +  M  M  M  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Infiltration Cellular, Lymphocyte    |    1     2  1           1              1     1     2  1     1            |             

                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  M  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperkeratosis                       |    2                                                        2     2      |             
      Epithelium, Hyperplasia, Squamous    |    1                                                                     |             

                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  A  +  M  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |          2  2              2     2                 2  2                  |             
      Ectasia                              | 1  2  1  1  1     1     1  2     2  2     1  1  1  2  2  2  1  2  2  1  1|             
      Hyperplasia, Atypical                |                                                          1               |             
      Hyperplasia                          |                                                    2           1         |             
      Inflammation, Chronic Active         |                         1                          1  1  2     1         |             
      Mineralization                       | 2                                                  1                     |             
      Necrosis                             |                                                                          |             

 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             

 _____________________________________________________________________________________________________________________|             
NTP Experiment-Test: 05187-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           METHYLEUGENOL                                       Date: 07/20/98  
Route: GAVAGE                                                                                                     Time: 10:23:30  
                                                                                                                                    

 _____________________________________________________________________________________________________________________              
                                           | 5| 5| 6| 5| 6| 5| 6| 6| 7| 7| 5| 6| 6| 6| 6| 6| 6| 7| 5| 6| 6| 7| 6| 6| 7|             
                             DAY ON TEST   | 9| 1| 2| 0| 8| 3| 6| 8| 2| 1| 8| 5| 2| 5| 5| 3| 1| 1| 7| 2| 7| 3| 8| 8| 3|             
                                           | 6| 8| 4| 5| 6| 7| 2| 0| 3| 7| 8| 2| 6| 9| 4| 4| 5| 7| 7| 6| 9| 1| 7| 6| 0|             

 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    150                                    | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|             
    MG/KG                                  | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             

 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |             
                                           |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Blood Vessel                            | +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

                                            __________________________________________________________________________|             
   Heart                                   | +  +  M  +  +  M  M  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrium, Thrombosis                   |             4                    4                    4     4  4  4      |             
      Valve, Inflammation, Suppurative     |                                                 2                        |             
      Valve, Thrombosis                    | 2                                                                        |             

 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Degeneration, Fatty                  |                                                                          |             
      Hematopoietic Cell Proliferation     | 2     1        1  1                 1  1  1  1        2           1      |             
      Pigmentation, Hemosiderin            |                                                                          |             
      Subcapsular, Hyperplasia             | 1  1  2  2  2  2  2  2  1  2     1  2  2  1  2  2  2  2  2  2  2  1  1  2|             

                                            __________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                         2                                      2     2   |             

                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                  2     2                                 |             

                                            __________________________________________________________________________|             
   Parathyroid Gland                       | M  +  M  +  +  M  M  M  M  +  M  +  +  +  +  +  M  +  +  +  +  +  +  +  +|             

                                            __________________________________________________________________________|             
   Pituitary Gland                         | M  +  M  +  +  M  M  M  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  M  +|             
      Pars Distalis, Cyst                  |                                                                          |             
      Pars Distalis, Hyperplasia           |                            2                    1                        |             

                                            __________________________________________________________________________|             
   Thyroid Gland                           | M  +  M  +  +  M  M  M  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Follicular Cell, Hyperplasia         |                            1                                   2         |             

 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             

 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Clitoral Gland                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  M  +  +  +|             

                                            __________________________________________________________________________|             
   Ovary                                   | +  +  M  +  +  +  +  +  +  M  A  +  +  +  +  +  M  +  +  +  M  +  +  M  +|             
      Cyst                                 |             2                             2                              |             
      Thrombosis                           |                                                                4         |             

                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |                                                                          |             
      Hydrometra                           |          2     2                                                         |             
      Hyperplasia, Cystic                  |                                  2                                       |             

                                            __________________________________________________________________________|             
   Vagina                                  |          +                                                               |             

 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          | 4  3  3  3  3  3  3  3  3  3  3  3  3  3  2  3  4  3  3  3  4  3  4  3  3|             
      Myelofibrosis                        |                                              1                           |             

                                            __________________________________________________________________________|             
   Lymph Node                              |                                  +                                      +|             
      Inguinal, Infiltration Cellular,     |                                                                          |             

 _____________________________________________________________________________________________________________________|             
NTP Experiment-Test: 05187-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           METHYLEUGENOL                                       Date: 07/20/98  
Route: GAVAGE                                                                                                     Time: 10:23:30  
                                                                                                                                    

 _____________________________________________________________________________________________________________________              
                                           | 5| 5| 6| 5| 6| 5| 6| 6| 7| 7| 5| 6| 6| 6| 6| 6| 6| 7| 5| 6| 6| 7| 6| 6| 7|             
                             DAY ON TEST   | 9| 1| 2| 0| 8| 3| 6| 8| 2| 1| 8| 5| 2| 5| 5| 3| 1| 1| 7| 2| 7| 3| 8| 8| 3|             
                                           | 6| 8| 4| 5| 6| 7| 2| 0| 3| 7| 8| 2| 6| 9| 4| 4| 5| 7| 7| 6| 9| 1| 7| 6| 0|             

 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    150                                    | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|             
    MG/KG                                  | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             

 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
           Mast Cell                       |                                  3                                       |             

                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | M  +  M  +  +  M  M  M  M  +  M  +  +  +  +  +  M  +  +  +  +  +  +  M  +|             

                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  M  +  +  +  +  A  +  +  M  +  +  +  +  +  +  M  +  +  +  M|             

                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                                                                          |             
      Lymphoid Follicle, Depletion Cellular|                      3                                                   |             
      Lymphoid Follicle, Necrosis          |                                                                          |             
      Red Pulp, Hematopoietic Cell         |                                                                          |             
          Proliferation                    | 4  3  4  3  4  4  4  2  3  4     4  4  3  3  3  3  3  3  2  3  4  2  4  2|             

                                            __________________________________________________________________________|             
   Thymus                                  | +  M  M  +  M  M  M  M  M  +  A  +  M  M  +  +  +  +  +  M  +  +  +  M  +|             
      Cyst                                 |                            1                       2           1         |             
      Ectopic Parathyroid Gland            |                                                                          |             

 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  A  +  +  M  M  +  M  +  +  +  +  M  +  +  M|             

                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Subcutaneous Tissue, Infiltration    |                                                                          |             
          Cellular, Lymphocyte             | 1              1                                                         |             

 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

                                            __________________________________________________________________________|             
   Skeletal Muscle                         |                                                                          |             
      Infiltration Cellular, Lymphocyte    |                                                                          |             

 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Brain                                   | M  +  +  +  +  M  M  M  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  M  +|             

 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  M  M  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Infiltration Cellular, Lymphocyte    |                                                    3                     |             
      Inflammation, Chronic Active         |                                  2                                       |             
      Inflammation, Suppurative            |                                                                          |             
      Metaplasia, Osseous                  |                               1                                          |             
      Alveolus, Infiltration Cellular,     |                                                                          |             
           Histiocyte                      |             3                                                            |             

                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  I  I  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Suppurative            |                                  1  3                 2     1  1  1     1|             
      Nasolacrimal Duct, Inflammation,     |                                                                          |             
           Suppurative                     |    2                             2     2        2        1               |             

                                            __________________________________________________________________________|             
   Trachea                                 | +  +  M  +  +  M  M  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             

 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             

 _____________________________________________________________________________________________________________________|             
NTP Experiment-Test: 05187-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           METHYLEUGENOL                                       Date: 07/20/98  
Route: GAVAGE                                                                                                     Time: 10:23:30  
                                                                                                                                    

 _____________________________________________________________________________________________________________________              
                                           | 5| 5| 6| 5| 6| 5| 6| 6| 7| 7| 5| 6| 6| 6| 6| 6| 6| 7| 5| 6| 6| 7| 6| 6| 7|             
                             DAY ON TEST   | 9| 1| 2| 0| 8| 3| 6| 8| 2| 1| 8| 5| 2| 5| 5| 3| 1| 1| 7| 2| 7| 3| 8| 8| 3|             
                                           | 6| 8| 4| 5| 6| 7| 2| 0| 3| 7| 8| 2| 6| 9| 4| 4| 5| 7| 7| 6| 9| 1| 7| 6| 0|             

 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    150                                    | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|             
    MG/KG                                  | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             

 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hydronephrosis                       | 4                                                                        |             
      Infiltration Cellular, Lymphocyte    | 2        1     1        1              1     2  1  2  1              1   |             
      Metaplasia, Osseous                  |                                                    2                     |             
      Mineralization                       |                                              3                           |             
      Nephropathy                          |    2                 1                       3                 2         |             
      Cortex, Cyst                         |                                                                          |             
      Glomerulus, Amyloid Deposition       |                                                                          |             
      Renal Tubule, Pigmentation,          |                                                                          |             
          Hemosiderin                      |                            3     4                                       |             

                                            __________________________________________________________________________|             
   Ureter                                  | +                                                                        |             

                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Infiltration Cellular, Lymphocyte    | 1        1     1           1     1           2     1  2  1        1  1   |             

 _____________________________________________________________________________________________________________________|             
NTP Experiment-Test: 05187-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           METHYLEUGENOL                                       Date: 07/20/98  
Route: GAVAGE                                                                                                     Time: 10:23:30  
                                                                                                                                    

 __________________________________________________________________________________________________________________________________ 
                                           | 6| 6| 7| 6| 6| 5| 6| 6| 5| 5| 4| 7| 6| 6| 6| 7| 6| 6| 6| 7| 3| 4| 6| 6| 7|            |
                             DAY ON TEST   | 0| 0| 1| 8| 9| 9| 7| 5| 4| 0| 7| 3| 7| 7| 0| 0| 6| 7| 2| 1| 7| 5| 8| 8| 1|            |
                                           | 7| 3| 2| 6| 2| 2| 6| 2| 8| 5| 7| 1| 6| 6| 1| 5| 6| 8| 7| 1| 9| 0| 1| 9| 8|      T (*) |

 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4|      A     |
    150                                    | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|      L     |
    MG/KG                                  | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |

 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  M  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +|  45        |

                                            __________________________________________________________________________|____________|
   Gallbladder                             | A  A  A  A  +  A  +  M  +  +  +  +  +  M  M  M  +  +  +  M  A  A  M  A  +|  24        |

                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  A  +  +  +  A  +  +  +  +  +  +  +  +  +  +|  47        |

                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |

                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  A  A  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +|  45        |

                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  M  A  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  43        |

                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  A  A  A  A  +  +  +  +  A  +  +  +  A  +  +  +  +  +  +  A  +  +  +|  40        |

                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  A  A  +  +  +  +  +  A  +  +  +  A  +  +  +  +  +  A  +  +  +  +|  43        |

                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Basophilic Focus                     |                                                                   X      |      3     |
      Clear Cell Focus                     |                                                                          |      1     |
      Eosinophilic Focus                   |                   X        X           X                    X     X      |      9     |
      Hematopoietic Cell Proliferation     | 1                 1        1     2  1  1        2  2     1              1|     24  1.6|
      Infiltration Cellular, Lymphocyte    |       1              2  2  1        1           1  2  1           1  2  1|     19  1.5|
      Inflammation, Chronic Active         |                1                 1                 1           1  2      |     10  1.7|
      Inflammation, Suppurative            |                                                                          |      1  4.0|
      Pigmentation, Hemosiderin            |       2        1  2              1  2              2                    2|     19  1.6|
      Bile Duct, Cyst                      |                                                             2            |      3  2.3|
      Bile Duct, Hyperplasia               |       2        2                                2  1              1      |      9  1.8|
      Hepatocyte, Hyperplasia, Adenomatous |    4                                                                     |      1  4.0|
      Hepatocyte, Necrosis                 | 2  2  3     3  2  1  2  2                    3                 1        2|     17  2.0|
      Hepatocyte, Vacuolization Cytoplasmic|    1                       2              2     1                        |     12  1.6|
      Hepatocyte, Centrilobular, Atrophy   |                                                 3                        |      1  3.0|
      Oval Cell, Hyperplasia               | 2  2        2  2  2  2  2  2        2  2        2  2  2     3  2  2  1  1|     38  1.9|
      Portal, Hypertrophy                  |    3           3  3  3  3  3        3  3        3  3  3     3  3  3     3|     23  3.0|

                                            __________________________________________________________________________|____________|
   Mesentery                               |                      +                                                   |   3        |
      Inflammation, Suppurative            |                                                                          |      1  4.0|
      Fat, Necrosis                        |                                                                          |      1  4.0|

                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  M  +  +  +  +  +  +  A  +  +  +  A  +  +  +  +  +  +  +  +  +  +|  46        |
      Infiltration Cellular, Lymphocyte    |                                                                          |      2  1.5|

                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  M  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +|  42        |
      Infiltration Cellular, Lymphocyte    | 2  1           1     1     1     1              1     2              1   |     18  1.2|

                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  A  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  46        |
      Hyperkeratosis                       |                                                                          |      3  2.0|
      Epithelium, Hyperplasia, Squamous    |                                                                          |      1  1.0|

                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  A  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  45        |
      Atrophy                              |                      2     2        2           2                        |     10  2.0|
      Ectasia                              | 1  1        1  1  1  2  1  1     2  2  2        2  1  2  1        1     2|     38  1.4|
      Hyperplasia, Atypical                |                                                                          |      1  1.0|

 __________________________________________________________________________________________________________________________________ 

  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
NTP Experiment-Test: 05187-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           METHYLEUGENOL                                       Date: 07/20/98  
Route: GAVAGE                                                                                                     Time: 10:23:30  
                                                                                                                                    

 __________________________________________________________________________________________________________________________________ 
                                           | 6| 6| 7| 6| 6| 5| 6| 6| 5| 5| 4| 7| 6| 6| 6| 7| 6| 6| 6| 7| 3| 4| 6| 6| 7|            |
                             DAY ON TEST   | 0| 0| 1| 8| 9| 9| 7| 5| 4| 0| 7| 3| 7| 7| 0| 0| 6| 7| 2| 1| 7| 5| 8| 8| 1|            |
                                           | 7| 3| 2| 6| 2| 2| 6| 2| 8| 5| 7| 1| 6| 6| 1| 5| 6| 8| 7| 1| 9| 0| 1| 9| 8|      T (*) |

 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4|      A     |
    150                                    | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|      L     |
    MG/KG                                  | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |

 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
                                           |                                                                          |            |
      Hyperplasia                          |                                                                          |      2  1.5|
      Inflammation, Chronic Active         |    1        1           1  1        1  2        1     1           1      |     14  1.1|
      Mineralization                       |                                                 2                        |      3  1.7|
      Necrosis                             |                                     2  1                                 |      2  1.5|

 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Blood Vessel                            | +  +  +  M  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +|  47        |

                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  M  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +|  44        |
      Atrium, Thrombosis                   |                                     2           3  4                     |      9  3.7|
      Valve, Inflammation, Suppurative     |                                                                          |      1  2.0|
      Valve, Thrombosis                    |                                                                          |      1  2.0|

 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Adrenal Cortex                          | +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Degeneration, Fatty                  |             2                                                            |      1  2.0|
      Hematopoietic Cell Proliferation     | 1     1                       3                                2         |     14  1.4|
      Pigmentation, Hemosiderin            |                                                 3                        |      1  3.0|
      Subcapsular, Hyperplasia             | 2  2  2     2  2  2  2  2  2  2  2  2  2  2  2  2  2  2  1  2  2  2  2  2|     48  1.8|

                                            __________________________________________________________________________|____________|
   Adrenal Medulla                         | +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Hyperplasia                          |                   1                                               3      |      5  2.0|

                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  M  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +|  47        |
      Hyperplasia                          |                                                                          |      2  2.0|

                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | M  +  +  M  +  +  +  +  +  +  M  +  M  +  M  +  +  +  +  +  +  M  +  +  +|  36        |

                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | M  +  +  M  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +|  40        |
      Pars Distalis, Cyst                  |                                        1                                 |      1  1.0|
      Pars Distalis, Hyperplasia           |                                  3                                       |      3  2.0|

                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  M  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +|  42        |
      Follicular Cell, Hyperplasia         |                                  2           2                    1      |      5  1.6|

 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |

 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Clitoral Gland                          | +  +  +  +  +  +  +  +  M  +  +  M  +  +  M  +  +  +  +  +  M  +  +  +  +|  44        |

                                            __________________________________________________________________________|____________|
   Ovary                                   | +  +  M  A  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +|  41        |
      Cyst                                 |                                     2                                   1|      4  1.8|
      Thrombosis                           |    4                                                                     |      2  4.0|

                                            __________________________________________________________________________|____________|
   Uterus                                  | +  +  +  A  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +|  47        |
      Hemorrhage                           |                      3                                                   |      1  3.0|

 __________________________________________________________________________________________________________________________________ 

  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
NTP Experiment-Test: 05187-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           METHYLEUGENOL                                       Date: 07/20/98  
Route: GAVAGE                                                                                                     Time: 10:23:30  
                                                                                                                                    

 __________________________________________________________________________________________________________________________________ 
                                           | 6| 6| 7| 6| 6| 5| 6| 6| 5| 5| 4| 7| 6| 6| 6| 7| 6| 6| 6| 7| 3| 4| 6| 6| 7|            |
                             DAY ON TEST   | 0| 0| 1| 8| 9| 9| 7| 5| 4| 0| 7| 3| 7| 7| 0| 0| 6| 7| 2| 1| 7| 5| 8| 8| 1|            |
                                           | 7| 3| 2| 6| 2| 2| 6| 2| 8| 5| 7| 1| 6| 6| 1| 5| 6| 8| 7| 1| 9| 0| 1| 9| 8|      T (*) |

 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4|      A     |
    150                                    | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|      L     |
    MG/KG                                  | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |

 __________________________________________________________________________________________________________________________________ 
 GENITAL SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
      Hydrometra                           |    3  3                                                  1               |      5  2.2|
      Hyperplasia, Cystic                  |                               3                                          |      2  2.5|

                                            __________________________________________________________________________|____________|
   Vagina                                  |                                                                          |   1        |

 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia                          | 4  4  3  3  2  4  4  2  3  2  3  3  3  3  3  3  3  3  3  3  3  3  3  3  4|     50  3.1|
      Myelofibrosis                        |                            2                          1                  |      3  1.3|

                                            __________________________________________________________________________|____________|
   Lymph Node                              |                               +              +                           |   4        |
      Inguinal, Infiltration Cellular,     |                                                                          |            |
           Mast Cell                       |                                                                          |      1  3.0|

                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | M  M  +  M  +  +  M  +  +  +  +  +  +  M  M  +  +  +  +  M  +  +  +  M  M|  32        |

                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | M  +  +  M  +  +  +  +  +  +  M  +  M  +  M  +  M  M  +  +  M  +  +  M  +|  36        |

                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  A  +  +  +  +  +  +  +  +  +  +  A  M  +  +  +  +  +  +  +  +  +|  46        |
      Atrophy                              |                                                             4            |      1  4.0|
      Lymphoid Follicle, Depletion Cellular|                   4                                                      |      2  3.5|
      Lymphoid Follicle, Necrosis          | 2                                                                        |      1  2.0|
      Red Pulp, Hematopoietic Cell         |                                                                          |            |
          Proliferation                    | 2  3  4     4  3  2  2  4     4  3  4  3        3  3  3  3     3  2  3  3|     44  3.2|

                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +  +  M  +  M  M  +  +  +  +  +  +  +  M  +  +  +  +  +  M  +  +  +  +|  33        |
      Cyst                                 |                                  1  2  1                          1      |      7  1.3|
      Ectopic Parathyroid Gland            |             1                                                            |      1  1.0|

 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Mammary Gland                           | M  +  +  A  +  M  +  +  +  +  M  M  +  +  +  +  +  +  +  M  +  +  M  +  +|  37        |

                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Subcutaneous Tissue, Infiltration    |                                                                          |            |
          Cellular, Lymphocyte             |                                                                          |      2  1.0|

 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |

                                            __________________________________________________________________________|____________|
   Skeletal Muscle                         | +                    +                       +                           |   3        |
      Infiltration Cellular, Lymphocyte    | 1                    1                                                   |      2  1.0|

 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Brain                                   | M  +  +  M  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +|  41        |

 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  M  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +|  45        |

 __________________________________________________________________________________________________________________________________ 

  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
NTP Experiment-Test: 05187-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           METHYLEUGENOL                                       Date: 07/20/98  
Route: GAVAGE                                                                                                     Time: 10:23:30  
                                                                                                                                    

 __________________________________________________________________________________________________________________________________ 
                                           | 6| 6| 7| 6| 6| 5| 6| 6| 5| 5| 4| 7| 6| 6| 6| 7| 6| 6| 6| 7| 3| 4| 6| 6| 7|            |
                             DAY ON TEST   | 0| 0| 1| 8| 9| 9| 7| 5| 4| 0| 7| 3| 7| 7| 0| 0| 6| 7| 2| 1| 7| 5| 8| 8| 1|            |
                                           | 7| 3| 2| 6| 2| 2| 6| 2| 8| 5| 7| 1| 6| 6| 1| 5| 6| 8| 7| 1| 9| 0| 1| 9| 8|      T (*) |

 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4|      A     |
    150                                    | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|      L     |
    MG/KG                                  | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |

 __________________________________________________________________________________________________________________________________ 
 RESPIRATORY SYSTEM - cont                 |                                                                          |            |
                                           |                                                                          |            |
      Infiltration Cellular, Lymphocyte    |                                                                          |      1  3.0|
      Inflammation, Chronic Active         |                   2                                                      |      2  2.0|
      Inflammation, Suppurative            |                      4                                                   |      1  4.0|
      Metaplasia, Osseous                  |                                                                          |      1  1.0|
      Alveolus, Infiltration Cellular,     |                                                                          |            |
           Histiocyte                      |                                                    2     2              2|      4  2.3|

                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +|  47        |
      Inflammation, Suppurative            |             2     1                                      1              1|     11  1.4|
      Nasolacrimal Duct, Inflammation,     |                                                                          |            |
           Suppurative                     |                   1                             1  1  1  1        2  2   |     12  1.5|

                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  M  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +|  44        |

 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |

 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Hydronephrosis                       |                2                                                         |      2  3.0|
      Infiltration Cellular, Lymphocyte    | 1  1  1        2     1     1                    1  1  1  1        1  1  1|     23  1.2|
      Metaplasia, Osseous                  |                                                                          |      1  2.0|
      Mineralization                       |                2                                                         |      2  2.5|
      Nephropathy                          |                2  3              1              1     1  1               |     10  1.7|
      Cortex, Cyst                         |                   1                                      2               |      2  1.5|
      Glomerulus, Amyloid Deposition       |                                                             4            |      1  4.0|
      Renal Tubule, Pigmentation,          |                                                                          |            |
          Hemosiderin                      |                                                                          |      2  3.5|

                                            __________________________________________________________________________|____________|
   Ureter                                  |                                                                          |   1        |

                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  M  +  +  +  +  +  +  +  +  +  +  M  +  +  M  +  +  +  +  +  +  +|  46        |
      Infiltration Cellular, Lymphocyte    | 1  1  1        1     1  1  1     1  1  2        1     1           1     1|     25  1.1|

 __________________________________________________________________________________________________________________________________ 

  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
NTP Experiment-Test: 05187-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           METHYLEUGENOL                                       Date: 07/20/98  
Route: GAVAGE                                                                                                     Time: 10:23:30  
                                                                                                                                    

 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 7| 7| 5| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 5|             
                             DAY ON TEST   | 0| 3| 3| 3| 3| 3| 3| 3| 3| 5| 3| 3| 3| 3| 3| 8| 3| 3| 3| 3| 3| 3| 3| 3| 4|             
                                           | 4| 1| 2| 2| 7| 2| 1| 0| 1| 4| 2| 0| 1| 1| 2| 3| 1| 0| 0| 1| 2| 0| 0| 0| 0|             

 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    0 MG/KG                                | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             

 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

                                            __________________________________________________________________________|             
   Gallbladder                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic Active         |                                                                          |             
      Peyer's Patch, Hyperplasia, Lymphoid |                                                                          |             

                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                           1                              |             
      Basophilic Focus                     |                            X                 X                           |             
      Clear Cell Focus                     |       X        X  X           X     X     X           X        X     X   |             
      Eosinophilic Focus                   |       X  X                    X     X                                    |             
      Fibrosis                             |                                                                          |             
      Hematopoietic Cell Proliferation     | 2                                                                 1      |             
      Infiltration Cellular, Lymphocyte    |                                        1                                 |             
      Inflammation, Chronic Active         | 1           1        1     1  1        1              1        1  1      |             
      Mixed Cell Focus                     |                      X  X     X        X     X  X           X  X         |             
      Pigmentation, Hemosiderin            |                                                                   1      |             
      Hepatocyte, Necrosis                 |             1        1                                            1      |             
      Hepatocyte, Vacuolization Cytoplasmic|          1     2        3                                1               |             

                                            __________________________________________________________________________|             
   Mesentery                               |                         +                                                |             
      Thrombosis                           |                         4                                                |             

                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                                                          |             
      Infiltration Cellular, Lymphocyte    |                                                                          |             
      Inflammation, Chronic Active         |                                                                          |             
      Acinus, Atrophy                      |    1                                                                     |             

                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                                                                         3|             
      Infiltration Cellular, Lymphocyte    |       1     1  1  1  1  2  1  1     1  1  1  1        1  1     1  1  1  1|             

                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Squamous                |                                                                          |             
      Inflammation, Chronic Active         |                                        2                                 |             
      Epithelium, Hyperplasia, Squamous    |                   1                    1                          2      |             

                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Ectasia                              |             1     1        1  1                             1  1  1      |             
      Inflammation, Chronic Active         |                1  1           1                                          |             

                                            __________________________________________________________________________|             
   Tooth                                   |       +     +  +     +  +        +        +  +  +  +  +     +  +  +      |             
      Inflammation, Chronic Active         |                                                       3                  |             
      Malformation                         |       X     X  X     X  X        X        X  X  X  X  X     X  X  X      |             

 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             

 _____________________________________________________________________________________________________________________|             
NTP Experiment-Test: 05187-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           METHYLEUGENOL                                       Date: 07/20/98  
Route: GAVAGE                                                                                                     Time: 10:23:30  
                                                                                                                                    

 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 7| 7| 5| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 5|             
                             DAY ON TEST   | 0| 3| 3| 3| 3| 3| 3| 3| 3| 5| 3| 3| 3| 3| 3| 8| 3| 3| 3| 3| 3| 3| 3| 3| 4|             
                                           | 4| 1| 2| 2| 7| 2| 1| 0| 1| 4| 2| 0| 1| 1| 2| 3| 1| 0| 0| 1| 2| 0| 0| 0| 0|             

 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    0 MG/KG                                | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             

 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |             
                                           |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Blood Vessel                            | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrium, Thrombosis                   |                                                                          |             

 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Degeneration, Fatty                  |                                                                          |             
      Subcapsular, Hyperplasia             | 2  1  2     1  2  3  2  1  1  3  2     1  1  2  1  1  1           1  1   |             

                                            __________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          | 3     3  3  2  3  3                 2  2  2  3  3  3  2  2  2  3  3  2   |             

                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  M  M  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +|             

                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +|             
      Pars Distalis, Cyst                  |                                                             2  2         |             

                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Follicle, Cyst                       |                            2                                             |             
      Follicular Cell, Hyperplasia         |             2                             1                              |             

 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             

 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Infiltration Cellular, Lymphocyte    |                                                                          |             

                                            __________________________________________________________________________|             
   Preputial Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |          3     3                          2                              |             
      Infiltration Cellular, Lymphocyte    | 1           1     1  1     1                 1           1  1     1  1   |             
      Inflammation, Chronic Active         |                               2  4                                       |             

                                            __________________________________________________________________________|             
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Infiltration Cellular, Lymphocyte    |                                              1                           |             
      Inflammation, Chronic Active         |                                                                          |             

                                            __________________________________________________________________________|             
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Suppurative            |                                                                          |             

                                            __________________________________________________________________________|             
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |             3        3     3     3     3     3                    3      |             
      Infiltration Cellular, Mast Cell     |                                                                          |             

                                            __________________________________________________________________________|             
   Lymph Node                              |                                                                         +|             
      Lumbar, Hyperplasia, Plasma Cell     |                                                                          |             
      Mediastinal, Necrosis                |                                                                          |             
      Renal, Hyperplasia, Plasma Cell      |                                                                          |             

 _____________________________________________________________________________________________________________________|             
NTP Experiment-Test: 05187-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           METHYLEUGENOL                                       Date: 07/20/98  
Route: GAVAGE                                                                                                     Time: 10:23:30  
                                                                                                                                    

 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 7| 7| 5| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 5|             
                             DAY ON TEST   | 0| 3| 3| 3| 3| 3| 3| 3| 3| 5| 3| 3| 3| 3| 3| 8| 3| 3| 3| 3| 3| 3| 3| 3| 4|             
                                           | 4| 1| 2| 2| 7| 2| 1| 0| 1| 4| 2| 0| 1| 1| 2| 3| 1| 0| 0| 1| 2| 0| 0| 0| 0|             

 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    0 MG/KG                                | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             

 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                                                                          |             
      Hematopoietic Cell Proliferation     |                                                                          |             
      Inflammation, Chronic Active         |                                                                   2      |             
      Necrosis                             |                                                                          |             

                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoid Follicle, Hyperplasia,      |                                                                          |             
          Lymphoid                         |                                                                          |             
      Lymphoid Follicle, Necrosis          |                                                                          |             
      Red Pulp, Hematopoietic Cell         |                                                                          |             
          Proliferation                    | 2           1                                                     2      |             

                                            __________________________________________________________________________|             
   Thymus                                  | M  M  M  +  +  M  +  +  M  +  +  +  +  +  +  +  +  +  +  +  I  M  M  +  +|             
      Cyst                                 |                      1        1  2           2                           |             
      Thymocyte, Necrosis                  |                                                                          |             

 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Mammary Gland                           | M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  +  M  M  M  M  M  M  M  +|             

                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

                                            __________________________________________________________________________|             
   Skeletal Muscle                         |                                                                +         |             
      Infiltration Cellular, Lymphocyte    |                                                                          |             

 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Necrosis                             |                                                                         2|             

                                            __________________________________________________________________________|             
   Spinal Cord                             |                                                                          |             

 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic Active         |                                        2                                 |             
      Inflammation, Suppurative            |                                                                          |             
      Alveolar Epithelium, Hyperplasia     |       2  2                 1              2                              |             
      Alveolus, Infiltration Cellular,     |                                                                          |             
           Histiocyte                      |                                           1                              |             
      Bronchiole, Hyperplasia              |                                                                          |             

                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Suppurative            |                                                 1  2     1     1        2|             
      Polyp, Inflammatory                  |                                                    2                     |             
      Nasolacrimal Duct, Inflammation,     |                                                                          |             
           Suppurative                     |                                     1        1                 1         |             

                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

 _____________________________________________________________________________________________________________________|             
NTP Experiment-Test: 05187-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           METHYLEUGENOL                                       Date: 07/20/98  
Route: GAVAGE                                                                                                     Time: 10:23:30  
                                                                                                                                    

 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 7| 7| 5| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 5|             
                             DAY ON TEST   | 0| 3| 3| 3| 3| 3| 3| 3| 3| 5| 3| 3| 3| 3| 3| 8| 3| 3| 3| 3| 3| 3| 3| 3| 4|             
                                           | 4| 1| 2| 2| 7| 2| 1| 0| 1| 4| 2| 0| 1| 1| 2| 3| 1| 0| 0| 1| 2| 0| 0| 0| 0|             

 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    0 MG/KG                                | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             

 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             

 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Harderian Gland                         |          +                                                     +  +      |             

                                            __________________________________________________________________________|             
   Zymbal's Gland                          |                                                                   +      |             

 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Infiltration Cellular, Lymphocyte    |    1  1  1  1        1  2     1  2     1  1  1     1  1     1  2     1   |             
      Inflammation, Suppurative            |                                                                          |             
      Metaplasia, Osseous                  |                   2                                                      |             
      Nephropathy                          |    1  1  2  2  1  1  1  2  1  1  2  1  1  1  2  1  2  1  2  1  1  1  1  2|             
      Cortex, Cyst                         |       2        2  2  2           2                                      2|             

                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Infiltration Cellular, Lymphocyte    |                         1  1                 1              1            |             
      Inflammation, Chronic Active         |                                                                          |             

 _____________________________________________________________________________________________________________________|             
NTP Experiment-Test: 05187-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           METHYLEUGENOL                                       Date: 07/20/98  
Route: GAVAGE                                                                                                     Time: 10:23:30  
                                                                                                                                    

 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 4| 7| 5| 6| 7| 7| 7| 7| 7| 7| 5| 7| 7| 6| 7| 7| 7| 7| 4| 5|            |
                             DAY ON TEST   | 3| 3| 3| 3| 3| 3| 3| 8| 9| 3| 3| 3| 3| 3| 3| 7| 3| 3| 7| 3| 3| 3| 3| 7| 2|            |
                                           | 0| 1| 0| 2| 1| 0| 1| 0| 3| 0| 1| 2| 0| 2| 1| 0| 0| 2| 0| 2| 0| 0| 2| 7| 2|      T (*) |

 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      A     |
    0 MG/KG                                | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |

 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +   |  49        |

                                            __________________________________________________________________________|____________|
   Gallbladder                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A   |  48        |

                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +   |  49        |

                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +   |  49        |

                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +   |  49        |

                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +   |  47        |

                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +   |  49        |
      Inflammation, Chronic Active         |                                        2                                 |      1  2.0|
      Peyer's Patch, Hyperplasia, Lymphoid |                                                                4         |      1  4.0|

                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +   |  48        |

                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +   |  49        |
      Angiectasis                          |                                                                          |      1  1.0|
      Basophilic Focus                     |                                           X                    X  X      |      5     |
      Clear Cell Focus                     |          X                 X  X  X     X  X                    X         |     16     |
      Eosinophilic Focus                   |       X                       X     X           X           X  X         |     10     |
      Fibrosis                             |                2                                                         |      1  2.0|
      Hematopoietic Cell Proliferation     |                                              1                           |      3  1.3|
      Infiltration Cellular, Lymphocyte    |          1                             1           2     1        2      |      6  1.3|
      Inflammation, Chronic Active         |    1     1     2              1     1     2  3                 2  1  2   |     19  1.3|
      Mixed Cell Focus                     |                   X                                                      |      9     |
      Pigmentation, Hemosiderin            |                2                             3                           |      3  2.0|
      Hepatocyte, Necrosis                 |                2     4  1           2                                4   |      8  2.0|
      Hepatocyte, Vacuolization Cytoplasmic|                1                       2                 1               |      7  1.6|

                                            __________________________________________________________________________|____________|
   Mesentery                               |                                                                          |   1        |
      Thrombosis                           |                                                                          |      1  4.0|

                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +   |  49        |
      Cyst                                 |                                  2                                       |      1  2.0|
      Infiltration Cellular, Lymphocyte    |          1                                                               |      1  1.0|
      Inflammation, Chronic Active         |                            2                                             |      1  2.0|
      Acinus, Atrophy                      |                            2                       1                     |      3  1.3|

                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +   |  49        |
      Atrophy                              |                                                                          |      1  3.0|
      Infiltration Cellular, Lymphocyte    |       1  1  1     1  1  1              1  1        1     1  1  1  1      |     31  1.0|

                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +   |  49        |
      Hyperplasia, Squamous                |             3                                                            |      1  3.0|
      Inflammation, Chronic Active         |             2                                                            |      2  2.0|
      Epithelium, Hyperplasia, Squamous    |       2     3                                                            |      5  1.8|

                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +   |  49        |
      Ectasia                              |                                     1  1           1     1  1  1         |     13  1.0|

 __________________________________________________________________________________________________________________________________ 

  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
NTP Experiment-Test: 05187-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           METHYLEUGENOL                                       Date: 07/20/98  
Route: GAVAGE                                                                                                     Time: 10:23:30  
                                                                                                                                    

 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 4| 7| 5| 6| 7| 7| 7| 7| 7| 7| 5| 7| 7| 6| 7| 7| 7| 7| 4| 5|            |
                             DAY ON TEST   | 3| 3| 3| 3| 3| 3| 3| 8| 9| 3| 3| 3| 3| 3| 3| 7| 3| 3| 7| 3| 3| 3| 3| 7| 2|            |
                                           | 0| 1| 0| 2| 1| 0| 1| 0| 3| 0| 1| 2| 0| 2| 1| 0| 0| 2| 0| 2| 0| 0| 2| 7| 2|      T (*) |

 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      A     |
    0 MG/KG                                | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |

 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
                                           |                                                                          |            |
      Inflammation, Chronic Active         |                                  1     1  1     1  1        1  1         |     10  1.0|

                                            __________________________________________________________________________|____________|
   Tooth                                   |    +  +  +                    +           +  +  +  +        +            |  23        |
      Inflammation, Chronic Active         |                                                                          |      1  3.0|
      Malformation                         |       X  X                    X           X  X  X  X        X            |     22     |

 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Blood Vessel                            | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +   |  49        |

                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +   |  49        |
      Atrium, Thrombosis                   |                                                       3                  |      1  3.0|

 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +   |  49        |
      Degeneration, Fatty                  |                            1                                             |      1  1.0|
      Subcapsular, Hyperplasia             |    1  2  1  2  1  3     1  2  1  1  1     3  1  2  1  1  1     1     1   |     38  1.5|

                                            __________________________________________________________________________|____________|
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +   |  49        |

                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +   |  49        |
      Hyperplasia                          |    2  3     3  3     2        3     3     3  3  3  3  2  3  3            |     32  2.7|

                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  M  +  +  M  +  +  +  +  +   |  43        |

                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  I  +  +  M  +  +  +  +  +   |  45        |
      Pars Distalis, Cyst                  |                      2                             1        1            |      5  1.6|

                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +   |  49        |
      Follicle, Cyst                       |                               2                                          |      2  2.0|
      Follicular Cell, Hyperplasia         |                                                                          |      2  1.5|

 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |

 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +   |  49        |
      Infiltration Cellular, Lymphocyte    |                   2                                                      |      1  2.0|

                                            __________________________________________________________________________|____________|
   Preputial Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +   |  49        |
      Cyst                                 |                      3     2                       3           3         |      7  2.7|
      Infiltration Cellular, Lymphocyte    | 2  1        1              1  1        1                 1               |     17  1.1|
      Inflammation, Chronic Active         |                               2                                          |      3  2.7|

                                            __________________________________________________________________________|____________|
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +   |  49        |
      Infiltration Cellular, Lymphocyte    |                                                                          |      1  1.0|
      Inflammation, Chronic Active         |                         2                    2                           |      2  2.0|

                                            __________________________________________________________________________|____________|
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +   |  49        |
      Inflammation, Suppurative            |                                              4                           |      1  4.0|

 __________________________________________________________________________________________________________________________________ 

  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
NTP Experiment-Test: 05187-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           METHYLEUGENOL                                       Date: 07/20/98  
Route: GAVAGE                                                                                                     Time: 10:23:30  
                                                                                                                                    

 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 4| 7| 5| 6| 7| 7| 7| 7| 7| 7| 5| 7| 7| 6| 7| 7| 7| 7| 4| 5|            |
                             DAY ON TEST   | 3| 3| 3| 3| 3| 3| 3| 8| 9| 3| 3| 3| 3| 3| 3| 7| 3| 3| 7| 3| 3| 3| 3| 7| 2|            |
                                           | 0| 1| 0| 2| 1| 0| 1| 0| 3| 0| 1| 2| 0| 2| 1| 0| 0| 2| 0| 2| 0| 0| 2| 7| 2|      T (*) |

 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      A     |
    0 MG/KG                                | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |

 __________________________________________________________________________________________________________________________________ 
 GENITAL SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +   |  49        |

 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +   |  49        |
      Hyperplasia                          |       3              3     2        2     2  3                       3   |     14  2.8|
      Infiltration Cellular, Mast Cell     |             1                                                            |      1  1.0|

                                            __________________________________________________________________________|____________|
   Lymph Node                              |                      +                       +                           |   3        |
      Lumbar, Hyperplasia, Plasma Cell     |                                              3                           |      1  3.0|
      Mediastinal, Necrosis                |                      2                                                   |      1  2.0|
      Renal, Hyperplasia, Plasma Cell      |                                              3                           |      1  3.0|

                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M   |  48        |

                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +   |  49        |
      Atrophy                              |                                              3                           |      1  3.0|
      Hematopoietic Cell Proliferation     |                      2                       2                           |      2  2.0|
      Inflammation, Chronic Active         |                                                                          |      1  2.0|
      Necrosis                             |                2     3                                                   |      2  2.5|

                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +   |  49        |
      Lymphoid Follicle, Hyperplasia,      |                                                                          |            |
          Lymphoid                         |                                                                3         |      1  3.0|
      Lymphoid Follicle, Necrosis          |                2     2  2                                                |      3  2.0|
      Red Pulp, Hematopoietic Cell         |                                                                          |            |
          Proliferation                    |                      3              3        3        4        2  3  1   |     10  2.4|

                                            __________________________________________________________________________|____________|
   Thymus                                  | +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  M  +  M   |  37        |
      Cyst                                 |       1     2                 2  1  2              1                     |     10  1.5|
      Thymocyte, Necrosis                  |                      4                                                   |      1  4.0|

 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Mammary Gland                           | M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M   |   2        |

                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +   |  49        |

 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +   |  49        |

                                            __________________________________________________________________________|____________|
   Skeletal Muscle                         |                                                          +               |   2        |
      Infiltration Cellular, Lymphocyte    |                                                          1               |      1  1.0|

 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +   |  49        |
      Necrosis                             |                                                                          |      1  2.0|

                                            __________________________________________________________________________|____________|
   Spinal Cord                             |    +                                               +                     |   2        |

 __________________________________________________________________________________________________________________________________ 

  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
NTP Experiment-Test: 05187-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           METHYLEUGENOL                                       Date: 07/20/98  
Route: GAVAGE                                                                                                     Time: 10:23:30  
                                                                                                                                    

 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 4| 7| 5| 6| 7| 7| 7| 7| 7| 7| 5| 7| 7| 6| 7| 7| 7| 7| 4| 5|            |
                             DAY ON TEST   | 3| 3| 3| 3| 3| 3| 3| 8| 9| 3| 3| 3| 3| 3| 3| 7| 3| 3| 7| 3| 3| 3| 3| 7| 2|            |
                                           | 0| 1| 0| 2| 1| 0| 1| 0| 3| 0| 1| 2| 0| 2| 1| 0| 0| 2| 0| 2| 0| 0| 2| 7| 2|      T (*) |

 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      A     |
    0 MG/KG                                | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |

 __________________________________________________________________________________________________________________________________ 
 NERVOUS SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |

 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +   |  49        |
      Inflammation, Chronic Active         |                                                    1                     |      2  1.5|
      Inflammation, Suppurative            |          1                                                               |      1  1.0|
      Alveolar Epithelium, Hyperplasia     |          1                 2                                1            |      7  1.6|
      Alveolus, Infiltration Cellular,     |                                                                          |            |
           Histiocyte                      |                                                       3                  |      2  2.0|
      Bronchiole, Hyperplasia              |             2                                                            |      1  2.0|

                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +   |  49        |
      Inflammation, Suppurative            |    1                 1                             1        1            |      9  1.2|
      Polyp, Inflammatory                  |                                                                          |      1  2.0|
      Nasolacrimal Duct, Inflammation,     |                                                                          |            |
           Suppurative                     |    1                                                                     |      4  1.0|

                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +   |  49        |

 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Harderian Gland                         |                                              +                           |   4        |

                                            __________________________________________________________________________|____________|
   Zymbal's Gland                          | +                                +                                +      |   4        |

 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +   |  49        |
      Infiltration Cellular, Lymphocyte    | 1     1  1  1        1  1        1     1  1     1        1  1     2      |     29  1.1|
      Inflammation, Suppurative            |                                              3                           |      1  3.0|
      Metaplasia, Osseous                  |                                                                          |      1  2.0|
      Nephropathy                          | 1  1  1  1  1  2  1        1  1  1  1  1  1     1  1     1  1  1  1      |     43  1.2|
      Cortex, Cyst                         | 2  2                    2                       2                        |     10  2.0|

                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +   |  49        |
      Infiltration Cellular, Lymphocyte    |                   1                             1                        |      6  1.0|
      Inflammation, Chronic Active         |                                              3                           |      1  3.0|

 __________________________________________________________________________________________________________________________________ 

  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
NTP Experiment-Test: 05187-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           METHYLEUGENOL                                       Date: 07/20/98  
Route: GAVAGE                                                                                                     Time: 10:23:30  
                                                                                                                                    

 _____________________________________________________________________________________________________________________              
                                           | 7| 5| 7| 6| 7| 7| 6| 7| 7| 7| 6| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 3| 9| 3| 7| 3| 3| 9| 3| 3| 3| 3| 3| 3| 3| 3| 3| 7| 3| 1| 3| 3| 3| 3| 3| 3|             
                                           | 1| 3| 1| 0| 0| 1| 4| 0| 0| 0| 6| 2| 0| 1| 1| 0| 3| 2| 2| 1| 0| 0| 0| 1| 0|             

 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    37 MG/KG                               | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             

 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

                                            __________________________________________________________________________|             
   Gallbladder                             | +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +|             

                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic Active         |                                                                          |             
      Ulcer                                |                                                                          |             

                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Peyer's Patch, Hyperplasia, Lymphoid |                                                                          |             

                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +|             

                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Basophilic Focus                     | X  X                                                                     |             
      Clear Cell Focus                     |    X           X     X           X                 X                     |             
      Eosinophilic Focus                   |    X        X              X     X  X     X  X     X     X        X  X  X|             
      Fibrosis                             |                                           2                              |             
      Hematopoietic Cell Proliferation     |             1           1        2     2  1                 1            |             
      Infiltration Cellular, Lymphocyte    |                   1                    1                                 |             
      Inflammation, Chronic Active         |             2  1  1  1     1           1  3              1  2           1|             
      Mineralization                       |                                  1                                       |             
      Mixed Cell Focus                     |    X                    X     X  X           X           X           X  X|             
      Pigmentation, Hemosiderin            |                                        2  2                              |             
      Tension Lipidosis                    |                                                                      X   |             
      Bile Duct, Cyst                      |       2                                                                  |             
      Bile Duct, Hyperplasia               |                                                                          |             
      Hepatocyte, Necrosis                 |                   1                 1           4     3                  |             
      Hepatocyte, Vacuolization Cytoplasmic|                   1           1  1                                       |             
      Oval Cell, Hyperplasia               |          1  1     1                    1  1     2     1                  |             
      Portal, Hypertrophy                  |                                                                3         |             

                                            __________________________________________________________________________|             
   Mesentery                               |                                                                          |             

                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Infiltration Cellular, Lymphocyte    |       1                    1              2                              |             

                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Infiltration Cellular, Lymphocyte    | 1     1     1     1     1  1  1  1  1        1  1        1     1  1  1  1|             

                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperkeratosis                       |                                                                          |             
      Epithelium, Hyperplasia, Squamous    |                                                                         3|             

                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |             1                                            1               |             
      Ectasia                              |       1     1  1     1     1     1  1  1              1  1  1            |             
      Hyperplasia                          |                                                          1               |             
      Inflammation, Chronic Active         |             1  1           2              1  1        1           1      |             
      Mineralization                       |                                                    1                     |             

                                            __________________________________________________________________________|             
   Tooth                                   |    +  +                 +                 +           +  +              +|             

 _____________________________________________________________________________________________________________________|             
NTP Experiment-Test: 05187-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           METHYLEUGENOL                                       Date: 07/20/98  
Route: GAVAGE                                                                                                     Time: 10:23:30  
                                                                                                                                    

 _____________________________________________________________________________________________________________________              
                                           | 7| 5| 7| 6| 7| 7| 6| 7| 7| 7| 6| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 3| 9| 3| 7| 3| 3| 9| 3| 3| 3| 3| 3| 3| 3| 3| 3| 7| 3| 1| 3| 3| 3| 3| 3| 3|             
                                           | 1| 3| 1| 0| 0| 1| 4| 0| 0| 0| 6| 2| 0| 1| 1| 0| 3| 2| 2| 1| 0| 0| 0| 1| 0|             

 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    37 MG/KG                               | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             

 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
                                           |                                                                          |             
      Inflammation, Chronic Active         |                                                          3               |             
      Malformation                         |    X  X                 X                 X           X                 X|             

 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Blood Vessel                            | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cardiomyopathy                       |                            2                                             |             
      Mineralization                       |                                                                          |             
      Artery, Inflammation, Chronic Active |                            2                                             |             
      Atrium, Thrombosis                   |          4                                                               |             
      Valve, Inflammation, Suppurative     |                                                                          |             

 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Accessory Adrenal Cortical Nodule    |                                                             2            |             
      Angiectasis                          |                                                                      3   |             
      Degeneration, Fatty                  |                                                                          |             
      Hypertrophy                          |                                                                         1|             
      Subcapsular, Hyperplasia             | 2  1  2  1  1  1  2  1  2  2  1  2  2  1  1  1  2  2  1  2  1        2  1|             

                                            __________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |    3  3  3  3     2           2  3        2  2  3  2  3                  |             

                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  M  +|             

                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  I  M  +  +  +  +  +  +  +  +  +  +  +  +|             
      Pars Distalis, Cyst                  | 1                                      2     1                 1         |             

                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic Active         |                1                                                         |             
      Follicle, Cyst                       |                                                                          |             
      Follicular Cell, Hyperplasia         |             2                                               2  2  2      |             

 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             

 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                                                          |             
      Infiltration Cellular, Lymphocyte    |                                                                          |             
      Mineralization                       |                                                                          |             

                                            __________________________________________________________________________|             
   Preputial Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                           3                              |             
      Infiltration Cellular, Lymphocyte    |    1              1                             1                    2   |             
      Inflammation, Chronic Active         | 3                                                                        |             

                                            __________________________________________________________________________|             
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic Active         |                                                                          |             

 _____________________________________________________________________________________________________________________|             
NTP Experiment-Test: 05187-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           METHYLEUGENOL                                       Date: 07/20/98  
Route: GAVAGE                                                                                                     Time: 10:23:30  
                                                                                                                                    

 _____________________________________________________________________________________________________________________              
                                           | 7| 5| 7| 6| 7| 7| 6| 7| 7| 7| 6| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 3| 9| 3| 7| 3| 3| 9| 3| 3| 3| 3| 3| 3| 3| 3| 3| 7| 3| 1| 3| 3| 3| 3| 3| 3|             
                                           | 1| 3| 1| 0| 0| 1| 4| 0| 0| 0| 6| 2| 0| 1| 1| 0| 3| 2| 2| 1| 0| 0| 0| 1| 0|             

 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    37 MG/KG                               | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             

 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
      Artery, Inflammation, Chronic Active |                            2                                             |             

                                            __________________________________________________________________________|             
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

                                            __________________________________________________________________________|             
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Germinal Epithelium, Atrophy         |                                                                          |             

 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          | 2     3  2  3  2  3  2     3  3        3  3  3  3     3     3           2|             

                                            __________________________________________________________________________|             
   Lymph Node                              |             +              +                                             |             

                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +|             
      Necrosis                             |                                                 1                        |             

                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  M  +  +  +  +  +|             
      Angiectasis                          |                                                                          |             
      Ectasia                              |                                                                   3      |             
      Necrosis                             |                   2                             1                        |             

                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrosis                             |                                                                          |             
      Mineralization                       |                                                                          |             
      Necrosis                             |                                                                          |             
      Pigmentation, Hemosiderin            |                                                                          |             
      Lymphoid Follicle, Necrosis          |                   2                             1                        |             
      Red Pulp, Erythrophagocytosis        |                                                                          |             
      Red Pulp, Hematopoietic Cell         |                                                                          |             
          Proliferation                    | 3        3  3     2  2     2  3        3  2     4     2     3            |             

                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  +  M  +  M  +  +  +  +  +  +  +  M  M  M  +|             
      Cyst                                 | 1  1  1        2        1                    1     2  2     1           2|             
      Ectopic Parathyroid Gland            |                         2                                                |             
      Thymocyte, Necrosis                  |                                                                          |             

 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Mammary Gland                           | M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M|             

                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

                                            __________________________________________________________________________|             
   Skeletal Muscle                         |                                                                          |             

 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic Active         |                                           2              2               |             
      Thrombosis                           |                      3                                                   |             

 _____________________________________________________________________________________________________________________|             
NTP Experiment-Test: 05187-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           METHYLEUGENOL                                       Date: 07/20/98  
Route: GAVAGE                                                                                                     Time: 10:23:30  
                                                                                                                                    

 _____________________________________________________________________________________________________________________              
                                           | 7| 5| 7| 6| 7| 7| 6| 7| 7| 7| 6| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 3| 9| 3| 7| 3| 3| 9| 3| 3| 3| 3| 3| 3| 3| 3| 3| 7| 3| 1| 3| 3| 3| 3| 3| 3|             
                                           | 1| 3| 1| 0| 0| 1| 4| 0| 0| 0| 6| 2| 0| 1| 1| 0| 3| 2| 2| 1| 0| 0| 0| 1| 0|             

 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    37 MG/KG                               | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             

 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
      Alveolar Epithelium, Hyperplasia     |                                           1  1                          3|             
      Alveolus, Infiltration Cellular,     |                                                                          |             
           Histiocyte                      |                                                                          |             

                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic Active         |                                                                          |             
      Inflammation, Suppurative            |    2  1  2     2                    2        1                       1   |             
      Polyp, Inflammatory                  |                                                                         2|             
      Nasolacrimal Duct, Inflammation,     |                                                                          |             
           Suppurative                     |       1                                                                  |             

                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Harderian Gland                         |       +                                                                  |             

 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Infiltration Cellular, Lymphocyte    | 1  1           1     1     1  2  1     1     1     1     1  3     1  1  1|             
      Inflammation, Suppurative            |                                                                          |             
      Metaplasia, Osseous                  |                                                                         1|             
      Mineralization                       |                                                                          |             
      Nephropathy                          | 2  1     1  1  2  2  2  1  1  1  2  2  3  3  2  2  2  2  2  3  1  1  1  2|             
      Artery, Inflammation, Chronic Active |                            2                                             |             
      Cortex, Cyst                         | 2     2                 1        1        3     2  2     2  3  2  2     3|             
      Papilla, Mineralization              |       3                                                                  |             
      Papilla, Necrosis                    |       4                                                                  |             
      Pelvis, Transitional Epithelium,     |                                                                          |             
           Hyperplasia                     |       1                                                                  |             

                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Calculus Gross Observation           |                                                                          |             
      Infiltration Cellular, Lymphocyte    |    1                    1                                                |             

 _____________________________________________________________________________________________________________________|             
NTP Experiment-Test: 05187-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           METHYLEUGENOL                                       Date: 07/20/98  
Route: GAVAGE                                                                                                     Time: 10:23:30  
                                                                                                                                    

 __________________________________________________________________________________________________________________________________ 
                                           | 6| 7| 7| 7| 7| 7| 6| 7| 7| 5| 7| 7| 7| 6| 7| 7| 5| 6| 7| 7| 7| 7| 4| 7| 7|            |
                             DAY ON TEST   | 9| 2| 3| 3| 3| 3| 8| 3| 3| 9| 3| 3| 3| 1| 3| 3| 4| 5| 3| 3| 3| 3| 8| 3| 3|            |
                                           | 4| 9| 2| 1| 0| 0| 7| 0| 0| 3| 0| 1| 1| 4| 2| 1| 6| 5| 1| 1| 1| 1| 8| 2| 0|      T (*) |

 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1|      A     |
    37 MG/KG                               | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |

 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |

                                            __________________________________________________________________________|____________|
   Gallbladder                             | A  A  +  +  +  +  A  +  M  +  +  +  +  +  +  +  +  +  M  +  +  +  +  M  +|  42        |

                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |

                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |

                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |

                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | A  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  47        |
      Inflammation, Chronic Active         |                                                                      3   |      1  3.0|
      Ulcer                                |                                                                      4   |      1  4.0|

                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Peyer's Patch, Hyperplasia, Lymphoid |                                                             3            |      1  3.0|

                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +|  48        |

                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Basophilic Focus                     |                                     X                                    |      3     |
      Clear Cell Focus                     |                      X                                X           X      |      8     |
      Eosinophilic Focus                   |          X  X                 X  X        X  X           X  X            |     20     |
      Fibrosis                             |                                        3     2              3            |      4  2.5|
      Hematopoietic Cell Proliferation     |                2                 1                          1            |      9  1.3|
      Infiltration Cellular, Lymphocyte    |                               1              2  3                        |      5  1.6|
      Inflammation, Chronic Active         |          1  1  1     1  2     1              2        1     1  1  2      |     21  1.3|
      Mineralization                       |                                                    2        3            |      3  2.0|
      Mixed Cell Focus                     |                      X        X                       X           X     X|     13     |
      Pigmentation, Hemosiderin            |                                              3              3     1      |      5  2.2|
      Tension Lipidosis                    |                                                                          |      1     |
      Bile Duct, Cyst                      |                                                                          |      1  2.0|
      Bile Duct, Hyperplasia               |                                        2                                 |      1  2.0|
      Hepatocyte, Necrosis                 |    1  1        1     1     2           4        3  3        4     2      |     14  2.2|
      Hepatocyte, Vacuolization Cytoplasmic|                               1                    3              1     2|      7  1.4|
      Oval Cell, Hyperplasia               |                                                             1            |      8  1.1|
      Portal, Hypertrophy                  |                                                                          |      1  3.0|

                                            __________________________________________________________________________|____________|
   Mesentery                               |                                                             +        +   |   2        |

                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Infiltration Cellular, Lymphocyte    |                               1                                          |      4  1.3|

                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Infiltration Cellular, Lymphocyte    |          1  1  1     1  1     1  1  1  1     1     1  1                 1|     29  1.0|

                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperkeratosis                       | 2                                                                        |      1  2.0|
      Epithelium, Hyperplasia, Squamous    |    2                                                                     |      2  2.5|

                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +|  48        |
      Atrophy                              |                      1                                                   |      3  1.0|

 __________________________________________________________________________________________________________________________________ 

  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
NTP Experiment-Test: 05187-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           METHYLEUGENOL                                       Date: 07/20/98  
Route: GAVAGE                                                                                                     Time: 10:23:30  
                                                                                                                                    

 __________________________________________________________________________________________________________________________________ 
                                           | 6| 7| 7| 7| 7| 7| 6| 7| 7| 5| 7| 7| 7| 6| 7| 7| 5| 6| 7| 7| 7| 7| 4| 7| 7|            |
                             DAY ON TEST   | 9| 2| 3| 3| 3| 3| 8| 3| 3| 9| 3| 3| 3| 1| 3| 3| 4| 5| 3| 3| 3| 3| 8| 3| 3|            |
                                           | 4| 9| 2| 1| 0| 0| 7| 0| 0| 3| 0| 1| 1| 4| 2| 1| 6| 5| 1| 1| 1| 1| 8| 2| 0|      T (*) |

 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1|      A     |
    37 MG/KG                               | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |

 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
                                           |                                                                          |            |
      Ectasia                              |    1     1  1        1  1     1     1  2  1  1           1     1  1     1|     25  1.0|
      Hyperplasia                          |                                                                          |      1  1.0|
      Inflammation, Chronic Active         |             1                          1                             1  1|     11  1.1|
      Mineralization                       |                                                                          |      1  1.0|

                                            __________________________________________________________________________|____________|
   Tooth                                   | +        +           +  +                             +           +      |  13        |
      Inflammation, Chronic Active         |                                                                          |      1  3.0|
      Malformation                         | X        X           X  X                             X           X      |     12     |

 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Blood Vessel                            | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |

                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cardiomyopathy                       |                                                                          |      1  2.0|
      Mineralization                       |                                                 1                        |      1  1.0|
      Artery, Inflammation, Chronic Active |                                                                          |      1  2.0|
      Atrium, Thrombosis                   |                                                                          |      1  4.0|
      Valve, Inflammation, Suppurative     | 2                                                                        |      1  2.0|

 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Accessory Adrenal Cortical Nodule    |          1                                                               |      2  1.5|
      Angiectasis                          |                                                                          |      1  3.0|
      Degeneration, Fatty                  |                                  1                                       |      1  1.0|
      Hypertrophy                          |             2                                         2              2  2|      5  1.8|
      Subcapsular, Hyperplasia             | 1  1  2  2  2  1     2  1     2  1  2     2  1  1     2  2     1  2  2   |     42  1.5|

                                            __________________________________________________________________________|____________|
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |

                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Hyperplasia                          | 3  3     3           3  3  2  3     3  3     3  3  2  3           3      |     26  2.7|

                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  M  +  +  +  +  +  +  M|  44        |

                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Pars Distalis, Cyst                  |                      2                       1                          2|      7  1.4|

                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inflammation, Chronic Active         |                                                                          |      1  1.0|
      Follicle, Cyst                       |                               2        1                                 |      2  1.5|
      Follicular Cell, Hyperplasia         |                2                             1                       2   |      7  1.9|

 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |

 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |

 __________________________________________________________________________________________________________________________________ 

  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
NTP Experiment-Test: 05187-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           METHYLEUGENOL                                       Date: 07/20/98  
Route: GAVAGE                                                                                                     Time: 10:23:30  
                                                                                                                                    

 __________________________________________________________________________________________________________________________________ 
                                           | 6| 7| 7| 7| 7| 7| 6| 7| 7| 5| 7| 7| 7| 6| 7| 7| 5| 6| 7| 7| 7| 7| 4| 7| 7|            |
                             DAY ON TEST   | 9| 2| 3| 3| 3| 3| 8| 3| 3| 9| 3| 3| 3| 1| 3| 3| 4| 5| 3| 3| 3| 3| 8| 3| 3|            |
                                           | 4| 9| 2| 1| 0| 0| 7| 0| 0| 3| 0| 1| 1| 4| 2| 1| 6| 5| 1| 1| 1| 1| 8| 2| 0|      T (*) |

 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1|      A     |
    37 MG/KG                               | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |

 __________________________________________________________________________________________________________________________________ 
 GENITAL SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cyst                                 |                      2                                                   |      1  2.0|
      Infiltration Cellular, Lymphocyte    |                                                       1                  |      1  1.0|
      Mineralization                       |                      2                                                   |      1  2.0|

                                            __________________________________________________________________________|____________|
   Preputial Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cyst                                 | 3     3                       3                          3           3   |      6  3.0|
      Infiltration Cellular, Lymphocyte    |       1              1  1        2  2     1  2        1        2  2     1|     15  1.4|
      Inflammation, Chronic Active         |                2     3                                               2   |      4  2.5|

                                            __________________________________________________________________________|____________|
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inflammation, Chronic Active         | 1                                      2                                 |      2  1.5|
      Artery, Inflammation, Chronic Active |                                                                          |      1  2.0|

                                            __________________________________________________________________________|____________|
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |

                                            __________________________________________________________________________|____________|
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Germinal Epithelium, Atrophy         |                      2                                                   |      1  2.0|

 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Hyperplasia                          |       2  2     2     3     3           3     2              2     2  3   |     26  2.6|

                                            __________________________________________________________________________|____________|
   Lymph Node                              |                                                          +  +            |   4        |

                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  M  +|  46        |
      Necrosis                             |                                                                          |      1  1.0|

                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  M  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  46        |
      Angiectasis                          |                                  2                                       |      1  2.0|
      Ectasia                              |                                                                          |      1  3.0|
      Necrosis                             |                                                                          |      2  1.5|

                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Fibrosis                             |                                                 3                        |      1  3.0|
      Mineralization                       |                                                 2                        |      1  2.0|
      Necrosis                             |                                                 4                        |      1  4.0|
      Pigmentation, Hemosiderin            |                                                 2                        |      1  2.0|
      Lymphoid Follicle, Necrosis          | 1                                      2           2              2      |      6  1.7|
      Red Pulp, Erythrophagocytosis        |                                        4                                 |      1  4.0|
      Red Pulp, Hematopoietic Cell         |                                                                          |            |
          Proliferation                    | 2           2  2           3                       2     3  2        3   |     20  2.6|

                                            __________________________________________________________________________|____________|
   Thymus                                  | +  M  I  +  +  M  M  +  +  +  +  +  +  +  +  +  +  +  I  +  +  +  +  +  +|  40        |
      Cyst                                 |          2           1     1     2  1  1  2        2     1               |     19  1.4|
      Ectopic Parathyroid Gland            |                                                                          |      1  2.0|
      Thymocyte, Necrosis                  |                                                                   4      |      1  4.0|

 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |

 __________________________________________________________________________________________________________________________________ 

  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
NTP Experiment-Test: 05187-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           METHYLEUGENOL                                       Date: 07/20/98  
Route: GAVAGE                                                                                                     Time: 10:23:30  
                                                                                                                                    

 __________________________________________________________________________________________________________________________________ 
                                           | 6| 7| 7| 7| 7| 7| 6| 7| 7| 5| 7| 7| 7| 6| 7| 7| 5| 6| 7| 7| 7| 7| 4| 7| 7|            |
                             DAY ON TEST   | 9| 2| 3| 3| 3| 3| 8| 3| 3| 9| 3| 3| 3| 1| 3| 3| 4| 5| 3| 3| 3| 3| 8| 3| 3|            |
                                           | 4| 9| 2| 1| 0| 0| 7| 0| 0| 3| 0| 1| 1| 4| 2| 1| 6| 5| 1| 1| 1| 1| 8| 2| 0|      T (*) |

 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1|      A     |
    37 MG/KG                               | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |

 __________________________________________________________________________________________________________________________________ 
 INTEGUMENTARY SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Mammary Gland                           | M  +  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  +  M  M  M  M|   2        |

                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |

 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |

                                            __________________________________________________________________________|____________|
   Skeletal Muscle                         |                                                          +               |   1        |

 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |

 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inflammation, Chronic Active         |                                                                          |      2  2.0|
      Thrombosis                           |                                        2                                 |      2  2.5|
      Alveolar Epithelium, Hyperplasia     |                2                             2        3                  |      6  2.0|
      Alveolus, Infiltration Cellular,     |                                                                          |            |
           Histiocyte                      |                                                          2               |      1  2.0|

                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inflammation, Chronic Active         |                                                    1                     |      1  1.0|
      Inflammation, Suppurative            |                         1  2     1     1        1  1                     |     13  1.4|
      Polyp, Inflammatory                  |                                                                          |      1  2.0|
      Nasolacrimal Duct, Inflammation,     |                                                                          |            |
           Suppurative                     |    3                                                                     |      2  2.0|

                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |

 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Harderian Gland                         |                                                                          |   1        |

 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Infiltration Cellular, Lymphocyte    |    1  1  1  1  1     1  1     1  1  1     1  1  1  1  1  1           1   |     32  1.1|
      Inflammation, Suppurative            |                                        2                                 |      1  2.0|
      Metaplasia, Osseous                  |                                                    1                    1|      3  1.0|
      Mineralization                       | 1                                                                        |      1  1.0|
      Nephropathy                          |    2  2  2  2  1     1  2  1  2  1  2     1  1     1  2  3  1  2  1  3  2|     45  1.7|
      Artery, Inflammation, Chronic Active |                                                                          |      1  2.0|
      Cortex, Cyst                         |       1  2  3  2        3  1  2  2  2     2     2     3     2     1     2|     27  2.0|
      Papilla, Mineralization              |                                                                          |      1  3.0|

 __________________________________________________________________________________________________________________________________ 

  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
NTP Experiment-Test: 05187-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           METHYLEUGENOL                                       Date: 07/20/98  
Route: GAVAGE                                                                                                     Time: 10:23:30  
                                                                                                                                    

 __________________________________________________________________________________________________________________________________ 
                                           | 6| 7| 7| 7| 7| 7| 6| 7| 7| 5| 7| 7| 7| 6| 7| 7| 5| 6| 7| 7| 7| 7| 4| 7| 7|            |
                             DAY ON TEST   | 9| 2| 3| 3| 3| 3| 8| 3| 3| 9| 3| 3| 3| 1| 3| 3| 4| 5| 3| 3| 3| 3| 8| 3| 3|            |
                                           | 4| 9| 2| 1| 0| 0| 7| 0| 0| 3| 0| 1| 1| 4| 2| 1| 6| 5| 1| 1| 1| 1| 8| 2| 0|      T (*) |

 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1|      A     |
    37 MG/KG                               | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |

 __________________________________________________________________________________________________________________________________ 
 URINARY SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
      Papilla, Necrosis                    |                                                                          |      1  4.0|
      Pelvis, Transitional Epithelium,     |                                                                          |            |
           Hyperplasia                     |                                                                          |      1  1.0|

                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Calculus Gross Observation           |                                        X                                 |      1     |
      Infiltration Cellular, Lymphocyte    |                            1        1                 1                  |      5  1.0|

 __________________________________________________________________________________________________________________________________ 

  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
NTP Experiment-Test: 05187-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           METHYLEUGENOL                                       Date: 07/20/98  
Route: GAVAGE                                                                                                     Time: 10:23:30  
                                                                                                                                    

 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 4| 7| 7| 7| 7| 7| 7| 6| 7| 7| 5| 7| 3| 5| 7| 7| 7| 7| 7| 5| 7| 6| 7|             
                             DAY ON TEST   | 3| 3| 8| 3| 3| 3| 3| 3| 3| 9| 3| 3| 7| 3| 2| 8| 3| 3| 3| 3| 3| 2| 3| 3| 3|             
                                           | 2| 0| 6| 0| 0| 1| 1| 1| 2| 1| 0| 1| 5| 2| 6| 9| 0| 1| 2| 2| 1| 2| 2| 9| 1|             

 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    75 MG/KG                               | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             

 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

                                            __________________________________________________________________________|             
   Gallbladder                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  A  +  +  +|             

                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +|             

                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +|             

                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  M  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +|             

                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Basophilic Focus                     |                                                                          |             
      Clear Cell Focus                     |                                                                          |             
      Eosinophilic Focus                   |    X  X     X  X  X  X  X  X  X  X  X  X     X     X  X  X              X|             
      Fibrosis                             |                                                          2               |             
      Hematopoietic Cell Proliferation     |                                           1                              |             
      Infiltration Cellular, Lymphocyte    |    1  2  1        1     1     2                 1  1     1               |             
      Inflammation, Chronic Active         |          1  1  1  1  1        2  1     1        1  1  1  2        1  1   |             
      Mineralization                       |                                                          1               |             
      Mixed Cell Focus                     | X        X                                      X                        |             
      Pigmentation, Hemosiderin            |                      2                                   2               |             
      Bile Duct, Cyst                      |                                                                          |             
      Hepatocyte, Necrosis                 |                1                 1                       2     2     1  1|             
      Hepatocyte, Vacuolization Cytoplasmic|                                                                   1      |             
      Hepatocyte, Centrilobular, Atrophy   |                                                                          |             
      Oval Cell, Hyperplasia               | 1     1  1     1     2     1  1  1  1        1  1  1     2  1            |             
      Portal, Hypertrophy                  |                      3        2     2                                    |             

                                            __________________________________________________________________________|             
   Mesentery                               |                                                                          |             
      Fat, Necrosis                        |                                                                          |             

                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |    2                                                                     |             

                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Infiltration Cellular, Lymphocyte    | 1  1  1     1  1  1     1     1  1           1  1  1        1        1  1|             

                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperkeratosis                       |                                     2                                    |             
      Inflammation, Chronic Active         |                2                                                         |             
      Epithelium, Hyperplasia, Squamous    |                3                                                         |             
      Epithelium, Ulcer                    |                                                                          |             

                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              | 1  1     2  2  2  2  2  1     1  4     1        1  1     1  1     1  1  1|             
      Ectasia                              | 1  1  1  2  2  2  2  2  2  1  1  1     1        1  1  1  1  1     1  2  1|             
      Hyperplasia, Atypical                |             1                                                            |             
      Hyperplasia                          |    1  2        3  2     2        2              2  1        1            |             
      Inflammation, Chronic Active         |          1  1  2  2  1  1     1  1     1        2  1     1           2   |             
      Mineralization                       |                                                                          |             
      Necrosis                             |                            2                                             |             

 _____________________________________________________________________________________________________________________|             
NTP Experiment-Test: 05187-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           METHYLEUGENOL                                       Date: 07/20/98  
Route: GAVAGE                                                                                                     Time: 10:23:30  
                                                                                                                                    

 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 4| 7| 7| 7| 7| 7| 7| 6| 7| 7| 5| 7| 3| 5| 7| 7| 7| 7| 7| 5| 7| 6| 7|             
                             DAY ON TEST   | 3| 3| 8| 3| 3| 3| 3| 3| 3| 9| 3| 3| 7| 3| 2| 8| 3| 3| 3| 3| 3| 2| 3| 3| 3|             
                                           | 2| 0| 6| 0| 0| 1| 1| 1| 2| 1| 0| 1| 5| 2| 6| 9| 0| 1| 2| 2| 1| 2| 2| 9| 1|             

 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    75 MG/KG                               | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             

 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Tooth                                   |                            +        +                    +               |             
      Malformation                         |                            X        X                    X               |             

 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Blood Vessel                            | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |          3                                                               |             
      Hypertrophy                          |                            2                                             |             
      Pigmentation, Hemosiderin            |                                                                          |             
      Subcapsular, Hyperplasia             |    2  1  2  1  1  1  1  2  2  2     2  2  2  1  2  2  1  1  1  1  1  2  1|             

                                            __________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |       2  2     3        3  2     3  3     3  3  3        2     3     2   |             

                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +|             

                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  I  I  +  +  +  M  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +|             
      Pars Distalis, Cyst                  |    1                                                                     |             

                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Follicle, Cyst                       |          2                             2                                 |             
      Follicular Cell, Hyperplasia         |                      1                                1  1               |             

 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             

 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Coagulating Gland                       | +  +                                                                     |             

                                            __________________________________________________________________________|             
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

                                            __________________________________________________________________________|             
   Preputial Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                      3     3                 3                           |             
      Infiltration Cellular, Lymphocyte    | 2           2                    1              1              2  1     1|             
      Inflammation, Chronic Active         |                      2                       2     4                     |             

                                            __________________________________________________________________________|             
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

                                            __________________________________________________________________________|             
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

                                            __________________________________________________________________________|             
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                                                                          |             
      Hyperplasia                          | 2  3  3  3  3  2     3  3     3  3        3  4  3  3  3  2  3     2     2|             
      Necrosis                             |                                                                          |             

                                            __________________________________________________________________________|             
   Lymph Node                              |    +                       +                                             |             

                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  M  +|             

 _____________________________________________________________________________________________________________________|             
NTP Experiment-Test: 05187-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           METHYLEUGENOL                                       Date: 07/20/98  
Route: GAVAGE                                                                                                     Time: 10:23:30  
                                                                                                                                    

 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 4| 7| 7| 7| 7| 7| 7| 6| 7| 7| 5| 7| 3| 5| 7| 7| 7| 7| 7| 5| 7| 6| 7|             
                             DAY ON TEST   | 3| 3| 8| 3| 3| 3| 3| 3| 3| 9| 3| 3| 7| 3| 2| 8| 3| 3| 3| 3| 3| 2| 3| 3| 3|             
                                           | 2| 0| 6| 0| 0| 1| 1| 1| 2| 1| 0| 1| 5| 2| 6| 9| 0| 1| 2| 2| 1| 2| 2| 9| 1|             

 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    75 MG/KG                               | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             

 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Hyperplasia, Lymphoid                |                                                                          |             
      Hyperplasia, Plasma Cell             |                                                             3            |             

                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Congestion                           |                                              3                           |             
      Ectasia                              |                3                                                         |             
      Hematopoietic Cell Proliferation     |                      3                                                   |             
      Hyperplasia, Lymphoid                |                                                                          |             
      Hyperplasia                          |                                                                          |             

                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                                     4                                    |             
      Lymphoid Follicle, Hyperplasia,      |                                                                          |             
          Lymphoid                         |                                                                          |             
      Lymphoid Follicle, Necrosis          |                                              2                           |             
      Red Pulp, Hematopoietic Cell         |                                                                          |             
          Proliferation                    |    1  3  2  1  2  2  3  2  2  2           4  2  2           3  3        2|             

                                            __________________________________________________________________________|             
   Thymus                                  | M  M  +  +  +  +  M  +  +  +  +  +  +  +  +  +  M  +  +  M  +  +  +  +  +|             
      Cyst                                 |             2  2           3     2  1              1              2      |             

 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Mammary Gland                           | M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M|             

                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

                                            __________________________________________________________________________|             
   Skeletal Muscle                         |                +                                                         |             
      Infiltration Cellular, Lymphocyte    |                1                                                         |             

 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Suppurative            |                                                                          |             
      Alveolar Epithelium, Hyperplasia     |                1                                                         |             
      Alveolus, Infiltration Cellular,     |                                                                          |             
           Lymphocyte                      |                                                                          |             

                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Suppurative            |                   1                                   1     1  1         |             
      Nasolacrimal Duct, Inflammation,     |                                                                          |             
           Suppurative                     |                                                             2            |             

                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Eye                                     |                         +                                                |             

 _____________________________________________________________________________________________________________________|             
NTP Experiment-Test: 05187-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           METHYLEUGENOL                                       Date: 07/20/98  
Route: GAVAGE                                                                                                     Time: 10:23:30  
                                                                                                                                    

 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 4| 7| 7| 7| 7| 7| 7| 6| 7| 7| 5| 7| 3| 5| 7| 7| 7| 7| 7| 5| 7| 6| 7|             
                             DAY ON TEST   | 3| 3| 8| 3| 3| 3| 3| 3| 3| 9| 3| 3| 7| 3| 2| 8| 3| 3| 3| 3| 3| 2| 3| 3| 3|             
                                           | 2| 0| 6| 0| 0| 1| 1| 1| 2| 1| 0| 1| 5| 2| 6| 9| 0| 1| 2| 2| 1| 2| 2| 9| 1|             

 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    75 MG/KG                               | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             

 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM - cont              |                                                                          |             
                                           |                                                                          |             
      Cornea, Inflammation, Chronic Active |                         3                                                |             

                                            __________________________________________________________________________|             
   Harderian Gland                         |                         +                                   +            |             

 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Infiltration Cellular, Lymphocyte    |    1  1  1  1  2  1  1  1     1  1     1     1  1  1     1               |             
      Mineralization                       |                                                       1                  |             
      Nephropathy                          | 1  1  2  1  1  2  3     1  1  1  1  1  1  1  1  1  1  1  1  1     1  1  1|             
      Cortex, Cyst                         |                      2  2     2     1  2        2     2                  |             

                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Infiltration Cellular, Lymphocyte    |                   1              1  1           1           1     1      |             

 _____________________________________________________________________________________________________________________|             
NTP Experiment-Test: 05187-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           METHYLEUGENOL                                       Date: 07/20/98  
Route: GAVAGE                                                                                                     Time: 10:23:30  
                                                                                                                                    

 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 6| 6| 7| 7| 0| 7| 7| 7| 7| 7| 5| 7| 7|            |
                             DAY ON TEST   | 3| 2| 3| 3| 3| 3| 3| 3| 3| 7| 3| 3| 1| 3| 3| 3| 3| 3| 3| 3| 3| 3| 2| 3| 3|            |
                                           | 1| 2| 2| 0| 2| 0| 2| 0| 1| 2| 1| 0| 4| 0| 0| 1| 7| 1| 0| 0| 0| 2| 2| 0| 2|      T (*) |

 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|      A     |
    75 MG/KG                               | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |

 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |

                                            __________________________________________________________________________|____________|
   Gallbladder                             | +  M  +  +  +  +  +  +  M  +  +  +  A  +  +  +  A  +  +  +  +  +  +  +  +|  44        |

                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +|  48        |

                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |

                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  A  +  +  +  +  +  +  +  +|  48        |

                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |

                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +|  48        |

                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +|  49        |

                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Basophilic Focus                     |                      X                                                   |      1     |
      Clear Cell Focus                     |             X                                                           X|      2     |
      Eosinophilic Focus                   |                   X     X                 X        X  X  X     X        X|     25     |
      Fibrosis                             |                                                                          |      1  2.0|
      Hematopoietic Cell Proliferation     |             2           1  2  1                    1                 1   |      7  1.3|
      Infiltration Cellular, Lymphocyte    |                         1                                            2  1|     12  1.3|
      Inflammation, Chronic Active         | 1     1        1     1  1  2  1  1  2  1     2     2  1  2               |     28  1.3|
      Mineralization                       |                                                                          |      1  1.0|
      Mixed Cell Focus                     | X                 X  X        X                          X              X|      9     |
      Pigmentation, Hemosiderin            |    2                             3  2              1                     |      6  2.0|
      Bile Duct, Cyst                      |                                                    2                     |      1  2.0|
      Hepatocyte, Necrosis                 |                            4                                      2      |      8  1.8|
      Hepatocyte, Vacuolization Cytoplasmic|                                                                         1|      2  1.0|
      Hepatocyte, Centrilobular, Atrophy   |    3                                                                     |      1  3.0|
      Oval Cell, Hyperplasia               |    2           1  1        2  1  2  2  1           1  1     1        1  1|     27  1.2|
      Portal, Hypertrophy                  |    2                                3                 2              2   |      7  2.3|

                                            __________________________________________________________________________|____________|
   Mesentery                               |                         +                                                |   1        |
      Fat, Necrosis                        |                         4                                                |      1  4.0|

                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cyst                                 |                                                                          |      1  2.0|

                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Infiltration Cellular, Lymphocyte    |    1     1           1  1     1           1  1     1  1     1  1     1  1|     28  1.0|

                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperkeratosis                       |    2                                1                             2      |      4  1.8|
      Inflammation, Chronic Active         |                                        2                          2      |      3  2.0|
      Epithelium, Hyperplasia, Squamous    |                                        3                          1      |      3  2.3|
      Epithelium, Ulcer                    |                                                                   4      |      1  4.0|

                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +|  49        |
      Atrophy                              | 2  2  2  1  2  1     2  1  2     2           2        2  1  1  1     1  1|     35  1.5|
      Ectasia                              | 1  2  1  1  2  1  1  2  1  2  2  1  1        2     2  1     1        1  1|     40  1.4|

 __________________________________________________________________________________________________________________________________ 

  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
NTP Experiment-Test: 05187-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           METHYLEUGENOL                                       Date: 07/20/98  
Route: GAVAGE                                                                                                     Time: 10:23:30  
                                                                                                                                    

 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 6| 6| 7| 7| 0| 7| 7| 7| 7| 7| 5| 7| 7|            |
                             DAY ON TEST   | 3| 2| 3| 3| 3| 3| 3| 3| 3| 7| 3| 3| 1| 3| 3| 3| 3| 3| 3| 3| 3| 3| 2| 3| 3|            |
                                           | 1| 2| 2| 0| 2| 0| 2| 0| 1| 2| 1| 0| 4| 0| 0| 1| 7| 1| 0| 0| 0| 2| 2| 0| 2|      T (*) |

 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|      A     |
    75 MG/KG                               | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |

 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
                                           |                                                                          |            |
      Hyperplasia, Atypical                |                                                                          |      1  1.0|
      Hyperplasia                          |    2     1  2              1                 1     3                     |     15  1.7|
      Inflammation, Chronic Active         | 1  1  1  1  1     1     1        1                 2  1              1  2|     25  1.2|
      Mineralization                       | 1                                                                        |      1  1.0|
      Necrosis                             |                                                                          |      1  2.0|

                                            __________________________________________________________________________|____________|
   Tooth                                   |                                                          +               |   4        |
      Malformation                         |                                                          X               |      4     |

 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Blood Vessel                            | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |

                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |

 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Angiectasis                          |                                                                          |      1  3.0|
      Hypertrophy                          |                                                       1              2   |      3  1.7|
      Pigmentation, Hemosiderin            |                                           2                              |      1  2.0|
      Subcapsular, Hyperplasia             | 1  1  1  1  1  1  1  2  2     2  1  1  1  2  1        1     1  1  1  1  1|     44  1.3|

                                            __________________________________________________________________________|____________|
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |

                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia                          |    2                                2  2                 2        2      |     18  2.4|

                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  M  +  M  +  M  +  +  +  +  +  +  +  +  M  +  +|  44        |

                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  I  +  +|  44        |
      Pars Distalis, Cyst                  | 2                                         2                              |      3  1.7|

                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Follicle, Cyst                       |                                                                          |      2  2.0|
      Follicular Cell, Hyperplasia         |             1                                2              1            |      6  1.2|

 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |

 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Coagulating Gland                       |                                                                          |   2        |

                                            __________________________________________________________________________|____________|
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |

                                            __________________________________________________________________________|____________|
   Preputial Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cyst                                 |             3  3  3        3     3  2                 2                  |     10  2.8|
      Infiltration Cellular, Lymphocyte    |                   2     1     2           2           2              1  1|     14  1.5|
      Inflammation, Chronic Active         | 4        3  2              2                                   4         |      8  2.9|

                                            __________________________________________________________________________|____________|
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |

 __________________________________________________________________________________________________________________________________ 

  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
NTP Experiment-Test: 05187-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           METHYLEUGENOL                                       Date: 07/20/98  
Route: GAVAGE                                                                                                     Time: 10:23:30  
                                                                                                                                    

 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 6| 6| 7| 7| 0| 7| 7| 7| 7| 7| 5| 7| 7|            |
                             DAY ON TEST   | 3| 2| 3| 3| 3| 3| 3| 3| 3| 7| 3| 3| 1| 3| 3| 3| 3| 3| 3| 3| 3| 3| 2| 3| 3|            |
                                           | 1| 2| 2| 0| 2| 0| 2| 0| 1| 2| 1| 0| 4| 0| 0| 1| 7| 1| 0| 0| 0| 2| 2| 0| 2|      T (*) |

 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|      A     |
    75 MG/KG                               | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |

 __________________________________________________________________________________________________________________________________ 
 GENITAL SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |

                                            __________________________________________________________________________|____________|
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |

 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Atrophy                              |                                                 3                        |      1  3.0|
      Hyperplasia                          | 3  3        2        3     3  3  3     3  3  3     3        3  2     2   |     33  2.8|
      Necrosis                             |                                              2                           |      1  2.0|

                                            __________________________________________________________________________|____________|
   Lymph Node                              |             +                          +     +                           |   5        |

                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  47        |
      Hyperplasia, Lymphoid                |                         3                                            3   |      2  3.0|
      Hyperplasia, Plasma Cell             |                                                                          |      1  3.0|

                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +|  49        |
      Congestion                           |                                                                          |      1  3.0|
      Ectasia                              |                                                                          |      1  3.0|
      Hematopoietic Cell Proliferation     |                                                                          |      1  3.0|
      Hyperplasia, Lymphoid                |                         3                                            2   |      2  2.5|
      Hyperplasia                          |                                                    4                     |      1  4.0|

                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Atrophy                              |                                                 3                        |      2  3.5|
      Lymphoid Follicle, Hyperplasia,      |                                                                          |            |
          Lymphoid                         |                                                                      3   |      1  3.0|
      Lymphoid Follicle, Necrosis          |                                                                          |      1  2.0|
      Red Pulp, Hematopoietic Cell         |                                                                          |            |
          Proliferation                    |    2  2                    4        4        2     2        2     3  3   |     25  2.4|

                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +  M  +  M  M  +  M  +  M  +  +  +  +  +  +  +  M  +  I  +  +  +  +  +|  38        |
      Cyst                                 |                   2           2  2  1     2  2              1        2  1|     16  1.8|

 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Mammary Gland                           | M  M  M  +  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M|   1        |

                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |

 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |

                                            __________________________________________________________________________|____________|
   Skeletal Muscle                         |                               +                                      +   |   3        |
      Infiltration Cellular, Lymphocyte    |                               1                                          |      2  1.0|

 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |

 __________________________________________________________________________________________________________________________________ 

  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
NTP Experiment-Test: 05187-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           METHYLEUGENOL                                       Date: 07/20/98  
Route: GAVAGE                                                                                                     Time: 10:23:30  
                                                                                                                                    

 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 6| 6| 7| 7| 0| 7| 7| 7| 7| 7| 5| 7| 7|            |
                             DAY ON TEST   | 3| 2| 3| 3| 3| 3| 3| 3| 3| 7| 3| 3| 1| 3| 3| 3| 3| 3| 3| 3| 3| 3| 2| 3| 3|            |
                                           | 1| 2| 2| 0| 2| 0| 2| 0| 1| 2| 1| 0| 4| 0| 0| 1| 7| 1| 0| 0| 0| 2| 2| 0| 2|      T (*) |

 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|      A     |
    75 MG/KG                               | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |

 __________________________________________________________________________________________________________________________________ 
 NERVOUS SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |

 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inflammation, Suppurative            |                                                                   3      |      1  3.0|
      Alveolar Epithelium, Hyperplasia     | 2        3                                         1        2            |      5  1.8|
      Alveolus, Infiltration Cellular,     |                                                                          |            |
           Lymphocyte                      |                2                                                         |      1  2.0|

                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inflammation, Suppurative            |                            1  1     1  1                 1     1  2      |     11  1.1|
      Nasolacrimal Duct, Inflammation,     |                                                                          |            |
           Suppurative                     |    3                       3           2  2  2              1        2   |      8  2.1|

                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |

 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Eye                                     |                                                                          |   1        |
      Cornea, Inflammation, Chronic Active |                                                                          |      1  3.0|

                                            __________________________________________________________________________|____________|
   Harderian Gland                         |                         +                 +  +              +  +         |   7        |

 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Infiltration Cellular, Lymphocyte    | 1  1  2              1           1     1           1     1  1  1     3  1|     27  1.1|
      Mineralization                       |                            2                             1               |      3  1.3|
      Nephropathy                          | 1  1  1  1  1  1  1  1  1  2  1  1     1  1  1     2  1  1  1  2     1  1|     45  1.2|
      Cortex, Cyst                         |          2  2  3  2  2  2     2  1        2  2     2     2     2         |     20  2.0|

                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Infiltration Cellular, Lymphocyte    | 1     1  1                                                               |      9  1.0|

 __________________________________________________________________________________________________________________________________ 

  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
NTP Experiment-Test: 05187-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           METHYLEUGENOL                                       Date: 07/20/98  
Route: GAVAGE                                                                                                     Time: 10:23:30  
                                                                                                                                    

 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 3| 4| 7| 7| 7| 7| 5| 6| 5| 7| 7| 7| 7| 7| 5| 7| 7| 7| 5| 5| 7|             
                             DAY ON TEST   | 3| 3| 3| 3| 3| 5| 3| 3| 3| 3| 1| 8| 5| 3| 3| 3| 3| 3| 6| 3| 3| 3| 7| 6| 3|             
                                           | 1| 1| 0| 1| 9| 9| 1| 1| 0| 2| 2| 8| 4| 1| 2| 2| 1| 2| 9| 0| 2| 0| 9| 1| 2|             

 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    150                                    | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|             
    MG/KG                                  | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             

 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

                                            __________________________________________________________________________|             
   Gallbladder                             | M  +  +  +  A  +  +  +  M  M  +  +  M  +  +  +  +  +  +  M  +  M  +  A  +|             

                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +|             
      Peyer's Patch, Inflammation,         |                                                                          |             
          Suppurative                      |                                        3                                 |             

                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                                                                          |             
      Basophilic Focus                     |       X                                                                  |             
      Clear Cell Focus                     |                                                    X                     |             
      Eosinophilic Focus                   | X  X           X  X                                   X  X               |             
      Hematopoietic Cell Proliferation     |                1                 2     1  3                 1            |             
      Infiltration Cellular, Lymphocyte    | 1                                                        1     1         |             
      Inflammation, Chronic Active         | 2     2  1           1           2     1  2  1  2     2     1  1        1|             
      Mixed Cell Focus                     |    X              X                          X                          X|             
      Pigmentation, Hemosiderin            |                                                 1     1                 1|             
      Bile Duct, Hyperplasia               |                                                                          |             
      Hepatocyte, Necrosis                 | 1     1                       4        2                       1         |             
      Hepatocyte, Vacuolization Cytoplasmic| 1     1  1              1  1  2              1           2  2  3        3|             
      Hepatocyte, Centrilobular, Necrosis  |                                     3                                    |             
      Oval Cell, Hyperplasia               | 2  2  3  1        2  1  2  1  2  2  3  2  1  1  1  1     1  1  3  1  2  1|             
      Portal, Hypertrophy                  | 3  3  3  2           1  3  1  3     3  3  3  3  3  3  3  3  3  3  3  3  3|             

                                            __________________________________________________________________________|             
   Mesentery                               |                                                                          |             

                                            __________________________________________________________________________|             
   Oral Mucosa                             |                                                                          |             

                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Infiltration Cellular, Lymphocyte    |                                              1     1     2               |             
      Artery, Inflammation, Chronic Active |                2                                                         |             

                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Infiltration Cellular, Lymphocyte    | 1  1  1  1                 1     1  1  1  1  1  1  1     1  1  1  1     1|             

                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Epithelium, Hyperplasia, Squamous    |                                                                          |             

                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              | 2  3  3  3  2  3  3     2  2  2  3  2  3  3  3  2  3  2  3  3  3  2     2|             
      Ectasia                              | 2  1  2  1  2  1  1  1  2  2  1  2  3  2  2  2  1  1  1  2  2  2  2     2|             
      Hyperplasia, Atypical                |                                                          1               |             
      Hyperplasia                          | 1     1  2        1     1  4     1  1     1  2  1                 1      |             
      Inflammation, Chronic Active         | 1  1  1  2     1  1        2     1  2  1  1  2  1  1     1  1  1        1|             
      Inflammation, Suppurative            |                                                                          |             
      Mineralization                       |                               2                                         1|             
      Neuroendocrine Cell, Hyperplasia     |                                                                          |             

 _____________________________________________________________________________________________________________________|             
NTP Experiment-Test: 05187-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           METHYLEUGENOL                                       Date: 07/20/98  
Route: GAVAGE                                                                                                     Time: 10:23:30  
                                                                                                                                    

 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 3| 4| 7| 7| 7| 7| 5| 6| 5| 7| 7| 7| 7| 7| 5| 7| 7| 7| 5| 5| 7|             
                             DAY ON TEST   | 3| 3| 3| 3| 3| 5| 3| 3| 3| 3| 1| 8| 5| 3| 3| 3| 3| 3| 6| 3| 3| 3| 7| 6| 3|             
                                           | 1| 1| 0| 1| 9| 9| 1| 1| 0| 2| 2| 8| 4| 1| 2| 2| 1| 2| 9| 0| 2| 0| 9| 1| 2|             

 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    150                                    | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|             
    MG/KG                                  | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             

 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Tooth                                   |                                     +                 +  +               |             
      Inflammation, Chronic Active         |                                                                          |             
      Malformation                         |                                     X                 X  X               |             

 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Blood Vessel                            | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cardiomyopathy                       |                2                                                         |             
      Mineralization                       |                                                                      1   |             
      Artery, Inflammation, Chronic Active |                                                                          |             
      Atrium, Thrombosis                   |                                                                   4      |             

 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                                                4         |             
      Hypertrophy                          |                         2                                                |             
      Subcapsular, Hyperplasia             |    3  1  1     1  1  2     2  1  1  1  2  1     2  2  1  1  1  1  1  1  2|             

                                            __________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |          2     2  2        2  3  2  3                 2  2           2   |             

                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  M  +  +  +  M  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +|             

                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  M  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +|             
      Pars Distalis, Cyst                  |                                                                          |             

                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic Active         |             2  1                                                         |             
      Follicle, Cyst                       |                                                                          |             
      Follicular Cell, Hyperplasia         |                                                 3              1         |             

 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             

 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Infiltration Cellular, Lymphocyte    |                                                          1               |             

                                            __________________________________________________________________________|             
   Preputial Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                           2                              |             
      Infiltration Cellular, Lymphocyte    |       1     1           2           1  2     2  3        1  2  1         |             
      Inflammation, Chronic Active         |                                              2  3                        |             

                                            __________________________________________________________________________|             
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

                                            __________________________________________________________________________|             
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

                                            __________________________________________________________________________|             
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Germinal Epithelium, Atrophy         |                                                                          |             

 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             

 _____________________________________________________________________________________________________________________|             
NTP Experiment-Test: 05187-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           METHYLEUGENOL                                       Date: 07/20/98  
Route: GAVAGE                                                                                                     Time: 10:23:30  
                                                                                                                                    

 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 3| 4| 7| 7| 7| 7| 5| 6| 5| 7| 7| 7| 7| 7| 5| 7| 7| 7| 5| 5| 7|             
                             DAY ON TEST   | 3| 3| 3| 3| 3| 5| 3| 3| 3| 3| 1| 8| 5| 3| 3| 3| 3| 3| 6| 3| 3| 3| 7| 6| 3|             
                                           | 1| 1| 0| 1| 9| 9| 1| 1| 0| 2| 2| 8| 4| 1| 2| 2| 1| 2| 9| 0| 2| 0| 9| 1| 2|             

 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    150                                    | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|             
    MG/KG                                  | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             

 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          | 3  3  2  2              3     3  3  3  3  3  3  3  3     3  3  2     4   |             

                                            __________________________________________________________________________|             
   Lymph Node                              |                   +                                                      |             

                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  M  M  +  +  +  +  +  +  +  +  +  +  +  M  +|             

                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Lymphoid                |                                                                          |             
      Necrosis                             |             2                                                            |             

                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoid Follicle, Hyperplasia,      |                                                                          |             
          Lymphoid                         |                                                          2               |             
      Lymphoid Follicle, Necrosis          |             2                                         3                  |             
      Red Pulp, Hematopoietic Cell         |                                                                          |             
          Proliferation                    |                         3     2  4  4  3  4     2     2     2     2  3   |             

                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  I  +  M  M  +  M  +  +  +  +  +  +  +  M  +  +  +  +  +|             
      Cyst                                 |    1                                   2  1           2                  |             
      Ectopic Parathyroid Gland            |                                                                      2   |             
      Thymocyte, Necrosis                  |                                                                          |             

 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Mammary Gland                           | M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  +  M  M  M  M  M  M|             

                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Subcutaneous Tissue, Inflammation,   |                                                                          |             
           Suppurative                     |                                                                          |             

 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

                                            __________________________________________________________________________|             
   Skeletal Muscle                         |    +                             +                                       |             
      Infiltration Cellular, Lymphocyte    |                                                                          |             

 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

                                            __________________________________________________________________________|             
   Spinal Cord                             |                +                                                         |             
      Hemorrhage                           |                                                                          |             
      Nerve, Demyelination                 |                2                                                         |             

 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Infiltration Cellular, Lymphocyte    |    2                                                                     |             
      Thrombosis                           |                                                                          |             
      Alveolar Epithelium, Hyperplasia     |          1                          2                          2         |             
      Alveolus, Infiltration Cellular,     |                                                                          |             
           Histiocyte                      |                         1                 1                              |             
      Mediastinum, Inflammation, Chronic   |                                                                          |             
          Active                           |             2                                                            |             

 _____________________________________________________________________________________________________________________|             
NTP Experiment-Test: 05187-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           METHYLEUGENOL                                       Date: 07/20/98  
Route: GAVAGE                                                                                                     Time: 10:23:30  
                                                                                                                                    

 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 3| 4| 7| 7| 7| 7| 5| 6| 5| 7| 7| 7| 7| 7| 5| 7| 7| 7| 5| 5| 7|             
                             DAY ON TEST   | 3| 3| 3| 3| 3| 5| 3| 3| 3| 3| 1| 8| 5| 3| 3| 3| 3| 3| 6| 3| 3| 3| 7| 6| 3|             
                                           | 1| 1| 0| 1| 9| 9| 1| 1| 0| 2| 2| 8| 4| 1| 2| 2| 1| 2| 9| 0| 2| 0| 9| 1| 2|             

 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    150                                    | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|             
    MG/KG                                  | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             

 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
      Mediastinum, Necrosis                |             2                                                            |             

                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Suppurative            |          1           1                          1              2         |             
      Nasolacrimal Duct, Inflammation,     |                                                                          |             
           Suppurative                     |                                                       2           2      |             

                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Eye                                     |                                                       +                  |             
      Cornea, Inflammation, Chronic Active |                                                       3                  |             

                                            __________________________________________________________________________|             
   Harderian Gland                         |    +              +        +                          +     +            |             

 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Infiltration Cellular, Lymphocyte    | 1  1  1  1     1     1  1  1     1  1  1  1     1  1  1  3  2  1  1     1|             
      Inflammation, Chronic Active         |                                                                          |             
      Inflammation, Suppurative            |                               2                                          |             
      Metaplasia, Osseous                  |                                                                          |             
      Mineralization                       |                                                       2              1   |             
      Necrosis                             |                         2                                                |             
      Nephropathy                          | 1  1  2  1  1  1  1  1  1  2     1  1  1  1  1  1  2  1  2  1  1  1  2  2|             
      Cortex, Cyst                         |       2     1              3                          1  2  2            |             
      Renal Tubule, Pigmentation,          |                                                                          |             
          Hemosiderin                      |                                     3                                    |             

                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Infiltration Cellular, Lymphocyte    |       1                                1  1              1               |             

 _____________________________________________________________________________________________________________________|             
NTP Experiment-Test: 05187-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           METHYLEUGENOL                                       Date: 07/20/98  
Route: GAVAGE                                                                                                     Time: 10:23:30  
                                                                                                                                    

 __________________________________________________________________________________________________________________________________ 
                                           | 6| 7| 7| 7| 5| 7| 6| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5|            |
                             DAY ON TEST   | 0| 3| 3| 3| 8| 3| 7| 3| 3| 6| 3| 3| 3| 3| 3| 3| 3| 3| 2| 3| 3| 3| 0| 3| 4|            |
                                           | 4| 0| 0| 1| 3| 2| 3| 0| 1| 0| 0| 2| 1| 1| 2| 0| 1| 1| 7| 1| 1| 0| 5| 1| 3|      T (*) |

 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2|      A     |
    150                                    | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|      L     |
    MG/KG                                  | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |

 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |

                                            __________________________________________________________________________|____________|
   Gallbladder                             | +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  M  +|  39        |

                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |

                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |

                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |

                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |

                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +|  48        |
      Peyer's Patch, Inflammation,         |                                                                          |            |
          Suppurative                      |                                                                          |      1  3.0|

                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |

                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Atrophy                              |                      2                                                   |      1  2.0|
      Basophilic Focus                     |       X                             X                                    |      3     |
      Clear Cell Focus                     |    X                 X           X                             X  X      |      6     |
      Eosinophilic Focus                   |          X  X  X     X  X        X  X  X     X     X     X     X  X      |     19     |
      Hematopoietic Cell Proliferation     |          3        1                 1                                   1|      9  1.6|
      Infiltration Cellular, Lymphocyte    | 2                    1        1     1     1           2  1               |     10  1.2|
      Inflammation, Chronic Active         | 1  1  1        1        1     1  1  2  1  1  1              1  1  2  1   |     28  1.3|
      Mixed Cell Focus                     |    X                                         X                    X      |      7     |
      Pigmentation, Hemosiderin            |                                     2                             2      |      5  1.4|
      Bile Duct, Hyperplasia               |                            3                                             |      1  3.0|
      Hepatocyte, Necrosis                 |          2        2                 2        3                    1      |     10  1.9|
      Hepatocyte, Vacuolization Cytoplasmic|                1     1                                                   |     13  1.5|
      Hepatocyte, Centrilobular, Necrosis  |                            3                                             |      2  3.0|
      Oval Cell, Hyperplasia               | 2  1  1  1  2  1  2  1  1  2  1  1  1  1  1  1  1     2  1  2  1  2  2  2|     46  1.5|
      Portal, Hypertrophy                  | 4  3  1  1  3  3  3  3  3  3  3  3  3  3  3  3  1  3  2  3  3  3  2  3  4|     46  2.8|

                                            __________________________________________________________________________|____________|
   Mesentery                               |                   +                                                      |   1        |

                                            __________________________________________________________________________|____________|
   Oral Mucosa                             |                                                                   +      |   1        |

                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Infiltration Cellular, Lymphocyte    |                                                          1               |      4  1.3|
      Artery, Inflammation, Chronic Active |                                                                          |      1  2.0|

                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Infiltration Cellular, Lymphocyte    | 1  1  1     1  1     1     1  1  1  1     1  1        1  1  1     1  1   |     34  1.0|

                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Epithelium, Hyperplasia, Squamous    |                                     1              2                     |      2  1.5|

                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Atrophy                              | 3  2  3  2  3  3  2  2  3  2  2     3  2  2  3  3  3     2  3  3     3  2|     45  2.6|
      Ectasia                              | 1  2  2  2  2  2  1  2  2  3  2  1  2  1  2  1  1  1  1  2  2  1  2  2  1|     49  1.7|
      Hyperplasia, Atypical                |                                                                   1      |      2  1.0|

 __________________________________________________________________________________________________________________________________ 

  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
NTP Experiment-Test: 05187-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           METHYLEUGENOL                                       Date: 07/20/98  
Route: GAVAGE                                                                                                     Time: 10:23:30  
                                                                                                                                    

 __________________________________________________________________________________________________________________________________ 
                                           | 6| 7| 7| 7| 5| 7| 6| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5|            |
                             DAY ON TEST   | 0| 3| 3| 3| 8| 3| 7| 3| 3| 6| 3| 3| 3| 3| 3| 3| 3| 3| 2| 3| 3| 3| 0| 3| 4|            |
                                           | 4| 0| 0| 1| 3| 2| 3| 0| 1| 0| 0| 2| 1| 1| 2| 0| 1| 1| 7| 1| 1| 0| 5| 1| 3|      T (*) |

 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2|      A     |
    150                                    | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|      L     |
    MG/KG                                  | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |

 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
                                           |                                                                          |            |
      Hyperplasia                          |             1  1     3                    4        1        2     2  4   |     20  1.8|
      Inflammation, Chronic Active         | 1     1  2  1  1           1  1     2     1        1  2  1  1     2  2   |     33  1.3|
      Inflammation, Suppurative            |                      2                                                   |      1  2.0|
      Mineralization                       |                                           2           2                  |      4  1.8|
      Neuroendocrine Cell, Hyperplasia     |          4                 3                                1  4         |      4  3.0|

                                            __________________________________________________________________________|____________|
   Tooth                                   |                         +                                      +         |   5        |
      Inflammation, Chronic Active         |                         3                                                |      1  3.0|
      Malformation                         |                                                                X         |      4     |

 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Blood Vessel                            | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |

                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cardiomyopathy                       |             1                                                            |      2  1.5|
      Mineralization                       |                                                                          |      1  1.0|
      Artery, Inflammation, Chronic Active |                                     3                                    |      1  3.0|
      Atrium, Thrombosis                   |                                                             2            |      2  3.0|

 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Angiectasis                          |                                                                          |      1  4.0|
      Hypertrophy                          |                                                          2               |      2  2.0|
      Subcapsular, Hyperplasia             | 2  3  1  1  1  2  1     2  1  3  2  1  1     1  2  2  2  1  1  2  1  1   |     43  1.5|

                                            __________________________________________________________________________|____________|
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |

                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia                          |             2     2     2  2                          2        3  2      |     17  2.2|

                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  M  +  M  +  M  M  M  +  +  M  +  M  M  +  M  M  +  M  M  M  M  +  +|  33        |

                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  M  +  +  +  +  M  +  +  +  +  +  +  +  +  I  +  +  +  +|  45        |
      Pars Distalis, Cyst                  |                         1                                                |      1  1.0|

                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inflammation, Chronic Active         |                                  1                                       |      3  1.3|
      Follicle, Cyst                       |          2              2                                                |      2  2.0|
      Follicular Cell, Hyperplasia         | 1                                               2     1                  |      5  1.6|

 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |

 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Infiltration Cellular, Lymphocyte    |                                     1                                    |      2  1.0|

 __________________________________________________________________________________________________________________________________ 

  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
NTP Experiment-Test: 05187-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           METHYLEUGENOL                                       Date: 07/20/98  
Route: GAVAGE                                                                                                     Time: 10:23:30  
                                                                                                                                    

 __________________________________________________________________________________________________________________________________ 
                                           | 6| 7| 7| 7| 5| 7| 6| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5|            |
                             DAY ON TEST   | 0| 3| 3| 3| 8| 3| 7| 3| 3| 6| 3| 3| 3| 3| 3| 3| 3| 3| 2| 3| 3| 3| 0| 3| 4|            |
                                           | 4| 0| 0| 1| 3| 2| 3| 0| 1| 0| 0| 2| 1| 1| 2| 0| 1| 1| 7| 1| 1| 0| 5| 1| 3|      T (*) |

 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2|      A     |
    150                                    | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|      L     |
    MG/KG                                  | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |

 __________________________________________________________________________________________________________________________________ 
 GENITAL SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Preputial Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cyst                                 |       3           3                             3        3               |      5  2.8|
      Infiltration Cellular, Lymphocyte    |    1                 2  1        1           1     1  1  1               |     18  1.4|
      Inflammation, Chronic Active         |                                                                          |      2  2.5|

                                            __________________________________________________________________________|____________|
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |

                                            __________________________________________________________________________|____________|
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |

                                            __________________________________________________________________________|____________|
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Germinal Epithelium, Atrophy         |                                                                1         |      1  1.0|

 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia                          | 4              2  3     3  3  1     3     2  3  3  1  3  3  3  3  3  3  3|     35  2.8|

                                            __________________________________________________________________________|____________|
   Lymph Node                              |                   +                                                     +|   3        |

                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  M|  45        |

                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia, Lymphoid                |                            4                                             |      1  4.0|
      Necrosis                             |                                                                          |      1  2.0|

                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Lymphoid Follicle, Hyperplasia,      |                                                                          |            |
          Lymphoid                         |                                                       3           3      |      3  2.7|
      Lymphoid Follicle, Necrosis          |                                                                          |      2  2.5|
      Red Pulp, Hematopoietic Cell         |                                                                          |            |
          Proliferation                    | 3        2                 3  2     2        2     3        2            |     19  2.6|

                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  45        |
      Cyst                                 |    2  2              1        1  1        2        1        1            |     12  1.4|
      Ectopic Parathyroid Gland            |                                                                          |      1  2.0|
      Thymocyte, Necrosis                  |                            3                                             |      1  3.0|

 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Mammary Gland                           | M  +  M  M  M  M  +  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M|   3        |

                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Subcutaneous Tissue, Inflammation,   |                                                                          |            |
           Suppurative                     |                                                                         2|      1  2.0|

 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |

                                            __________________________________________________________________________|____________|
   Skeletal Muscle                         |    +                                                                     |   3        |
      Infiltration Cellular, Lymphocyte    |    1                                                                     |      1  1.0|

 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |

 __________________________________________________________________________________________________________________________________ 

  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
NTP Experiment-Test: 05187-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           METHYLEUGENOL                                       Date: 07/20/98  
Route: GAVAGE                                                                                                     Time: 10:23:30  
                                                                                                                                    

 __________________________________________________________________________________________________________________________________ 
                                           | 6| 7| 7| 7| 5| 7| 6| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5|            |
                             DAY ON TEST   | 0| 3| 3| 3| 8| 3| 7| 3| 3| 6| 3| 3| 3| 3| 3| 3| 3| 3| 2| 3| 3| 3| 0| 3| 4|            |
                                           | 4| 0| 0| 1| 3| 2| 3| 0| 1| 0| 0| 2| 1| 1| 2| 0| 1| 1| 7| 1| 1| 0| 5| 1| 3|      T (*) |

 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2|      A     |
    150                                    | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|      L     |
    MG/KG                                  | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |

 __________________________________________________________________________________________________________________________________ 
 NERVOUS SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |

                                            __________________________________________________________________________|____________|
   Spinal Cord                             |                                                                   +      |   2        |
      Hemorrhage                           |                                                                   3      |      1  3.0|
      Nerve, Demyelination                 |                                                                          |      1  2.0|

 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Infiltration Cellular, Lymphocyte    |                                                                          |      1  2.0|
      Thrombosis                           |          2                                                               |      1  2.0|
      Alveolar Epithelium, Hyperplasia     |                      2           1                                       |      5  1.6|
      Alveolus, Infiltration Cellular,     |                                                                          |            |
           Histiocyte                      |                                                                          |      2  1.0|
      Mediastinum, Inflammation, Chronic   |                                                                          |            |
          Active                           |                                                                          |      1  2.0|
      Mediastinum, Necrosis                |                                                                          |      1  2.0|

                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inflammation, Suppurative            |       1  1                             2  1  1                 1         |     10  1.2|
      Nasolacrimal Duct, Inflammation,     |                                                                          |            |
           Suppurative                     |                                                                          |      2  2.0|

                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |

 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Eye                                     |                                                                          |   1        |
      Cornea, Inflammation, Chronic Active |                                                                          |      1  3.0|

                                            __________________________________________________________________________|____________|
   Harderian Gland                         |                                           +                              |   6        |

 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Infiltration Cellular, Lymphocyte    |    1  1     1  1     1  1  1  1  1  1  1  1  1  2     1  1  1  1  1  1   |     40  1.1|
      Inflammation, Chronic Active         |                                     2                                    |      1  2.0|
      Inflammation, Suppurative            |                                                                          |      1  2.0|
      Metaplasia, Osseous                  |                2                                                         |      1  2.0|
      Mineralization                       |       1                                                  1               |      4  1.3|
      Necrosis                             |                                                                          |      1  2.0|
      Nephropathy                          | 1  2  2  2  1  2     2  2  1  2  2  1  2  1  2  2  2  2  2  1  2  2  1  3|     48  1.5|
      Cortex, Cyst                         |          2     3           3                 2     2     2     2     1   |     14  2.0|
      Renal Tubule, Pigmentation,          |                                                                          |            |
          Hemosiderin                      |                                                                          |      1  3.0|

 __________________________________________________________________________________________________________________________________ 

  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
NTP Experiment-Test: 05187-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           METHYLEUGENOL                                       Date: 07/20/98  
Route: GAVAGE                                                                                                     Time: 10:23:30  
                                                                                                                                    

 __________________________________________________________________________________________________________________________________ 
                                           | 6| 7| 7| 7| 5| 7| 6| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5|            |
                             DAY ON TEST   | 0| 3| 3| 3| 8| 3| 7| 3| 3| 6| 3| 3| 3| 3| 3| 3| 3| 3| 2| 3| 3| 3| 0| 3| 4|            |
                                           | 4| 0| 0| 1| 3| 2| 3| 0| 1| 0| 0| 2| 1| 1| 2| 0| 1| 1| 7| 1| 1| 0| 5| 1| 3|      T (*) |

 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2|      A     |
    150                                    | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|      L     |
    MG/KG                                  | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |

 __________________________________________________________________________________________________________________________________ 
 URINARY SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Infiltration Cellular, Lymphocyte    |    1  1        1           1  1                 1     1     1  1     1   |     14  1.0|

 __________________________________________________________________________________________________________________________________ 

  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                             ------------------------------------------------------------                                           
                             ----------              END OF REPORT             ----------                                           
                             ------------------------------------------------------------