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TDMS Study 05187-09 Pathology Tables

NTP                                          MEAN BODY WEIGHTS AND SURVIVAL TABLE                                 REPORT: EISRPT41  
LAB: Battelle Columbus                                  METHYLEUGENOL                                             DATE: 07/20/98    
EXPERIMENT: 05187 TEST: 09                                                                                        TIME: 08:37:12    
                                                CAGES FROM 0000 TO LAST CAGE                                      PAGE:    1        
TEST TYPE: CHRONIC                                  ROUTE: GAVAGE                                                 NTP:  C60991B     
CONT: NO1-ES-25337                                                                                                CAS: 93-15-2      
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               REASONS FOR REMOVAL:    ALL                                                                                          
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
               REMOVAL DATE RANGE:     ALL                                                                                          
                                                                                                                                    
               TREATMENT GROUPS:       INCLUDE ALL                                                                                  




NTP                                          MEAN BODY WEIGHTS AND SURVIVAL TABLE                                 REPORT: EISRPT41

LAB: BATTELLE COLUMBUS LABORATORY                     METHYLEUGENOL                                               DATE: 07/20/98


EXPERIMENT: 05187 TEST: 09                                                                                        TIME:  8:44:06



TEST TYPE: TWO YEAR                                 ROUTE: ORAL GAVAGE                                            NTP:  60991B

CONT: NO1-ES-25337                                                                                                CAS: 93-15-2

                                         MEAN BODY WEIGHTS AND SURVIVAL OF MALE RATS IN THE
                                            TWO YEAR ORAL GAVAGE STUDY OF METHYLEUGENOL

===================================================================================================================================
WEEK     0 MG/KG                37 MG/KG                 75 MG/KG                 150     MG/KG            300     MG/KG
         ----------------       ----------------         ----------------         ----------------         ----------------
          AV.WT.     NO.       AV.WT.  PERCENT  NO.     AV.WT.  PERCENT  NO.     AV.WT.  PERCENT  NO.     AV.WT.  PERCENT  NO.
         (GRAMS)     (A)       (GRAMS)  OF CNTL  (A)    (GRAMS)  OF CNTL  (A)    (GRAMS)  OF CNTL  (A)    (GRAMS)  OF CNTL  (A)
==================================================================================================================================

  B       126.7       60       126.1     99.5    50     126.8    100.1    50     124.3     98.1    50     126.4     99.8    60
  1       126.7       60       126.1     99.5    50     126.8    100.1    50     124.3     98.1    50     126.4     99.8    60
  5       246.5       60       243.8     98.9    50     242.8     98.5    49     245.3     99.5    50     243.2     98.7    59
  9       303.6       60       300.4     98.9    50     303.4     99.9    49     297.6     98.0    50     296.5     97.7    59
 13       341.1       60       342.4    100.4    50     338.7     99.3    49     332.4     97.4    50     324.5     95.1    59
 17       368.1       60       365.7     99.3    50     360.7     98.0    49     354.5     96.3    50     341.0     92.6    59
 21       386.4       60       384.2     99.4    50     378.9     98.1    49     373.0     96.5    50     354.6     91.8    59
 25       395.5       60       393.7     99.5    50     386.7     97.8    49     374.8     94.8    50     359.5     90.9    59
 29       414.7       55 (I)   409.7     98.8    50     398.1     96.0    49     385.3     92.9    50     371.4     89.6    53 (I)
 33       413.9       55       411.5     99.4    50     402.0     97.1    49     388.6     93.9    50     373.4     90.2    52
 37       426.0       55       415.7     97.6    50     403.2     94.6    49     393.8     92.4    50     378.6     88.9    52
 41       427.1       55       417.9     97.8    50     406.5     95.2    49     396.5     92.8    50     376.2     88.1    52
 45       440.8       55       424.5     96.3    50     415.7     94.3    49     401.0     91.0    50     384.0     87.1    51
 49       449.4       55       429.8     95.6    50     415.5     92.5    49     409.3     91.1    49     386.9     86.1    51
 53       454.8       49 (I)   430.6     94.7    50     416.4     91.6    49     403.5     88.7    49     389.3     85.6    46 (I)
 57       458.2       49       434.5     94.8    50     420.5     91.8    49     400.5     87.4    49     392.3     85.6    45
 61       462.2       49       431.4     93.3    48     419.6     90.8    49     403.2     87.2    48     394.0     85.2    45
 65       462.5       49       433.5     93.7    47     418.5     90.5    48     404.2     87.4    48     392.6     84.9    44
 69       464.0       49       434.1     93.6    47     419.7     90.5    47     397.5     85.7    46     384.2     82.8    44
 73       464.9       49       434.7     93.5    47     425.3     91.5    46     404.6     87.0    44     385.6     82.9    41
 77       466.1       47       435.1     93.3    47     425.3     91.2    44     404.9     86.9    43     376.3     80.7    33
 81       463.8       46       430.9     92.9    45     412.1     88.9    44     390.2     84.1    41     363.1     78.3    25
 85       461.2       44       437.5     94.9    41     416.0     90.2    41     382.3     82.9    37     336.6     73.0    19
 89       448.1       39       430.9     96.2    36     409.4     91.4    37     386.4     86.2    30     341.3     76.2    10
 93       443.7       36       421.7     95.0    33     392.8     88.5    31     346.2     78.0    23                         
 97       432.5       32       408.2     94.4    28     381.2     88.1    25     331.3     76.6    10                         
101       413.7       32       387.0     93.5    25     397.2     96.0    18                                                  

TERM. SAC.            20                         16                       15                        0                        0


===================================================================================================================================


    (A) NUMBER OF ANIMALS WEIGHED.  AT TERMINAL SACRIFICE, NUMBER
        OF ANIMALS ALIVE ON FIRST DAY OF TERMINAL SACRIFICE.
    (B) REFERS TO THE BEGINNING (INITIAL) BODY WEIGHT.
    (I) INTERIM SACRIFICE OCCURRED IN THIS WEEK.
    (*) THE NUMBER OF ANIMALS WEIGHED FOR THIS WEEK
         IS LESS THAN THE NUMBER OF ANIMALS SURVIVING.

                                         MEAN BODY WEIGHTS AND SURVIVAL OF FEMALE RATS IN THE
                                            TWO YEAR ORAL GAVAGE STUDY OF METHYLEUGENOL

===================================================================================================================================
WEEK     0 MG/KG                37 MG/KG                 75 MG/KG                 150     MG/KG            300     MG/KG
         ----------------       ----------------         ----------------         ----------------         ----------------
          AV.WT.     NO.       AV.WT.  PERCENT  NO.     AV.WT.  PERCENT  NO.     AV.WT.  PERCENT  NO.     AV.WT.  PERCENT  NO.
         (GRAMS)     (A)       (GRAMS)  OF CNTL  (A)    (GRAMS)  OF CNTL  (A)    (GRAMS)  OF CNTL  (A)    (GRAMS)  OF CNTL  (A)
==================================================================================================================================

  B       108.3       60       106.2     98.1    50     107.3     99.1    50     107.1     98.9    50     107.4     99.2    60
  1       108.3       60       106.2     98.1    50     107.3     99.1    50     107.1     98.9    50     107.4     99.2    60
  5       162.3       60       160.6     99.0    50     160.2     98.7    50     161.2     99.3    50     157.8     97.2    60
  9       185.7       60       185.3     99.8    50     183.4     98.8    50     182.6     98.3    50     178.2     96.0    60
 13       202.6       60       199.0     98.2    50     199.2     98.3    50     194.9     96.2    50     188.5     93.0    60
 17       211.1       60       206.6     97.9    50     206.0     97.6    50     197.1     93.4    50     192.0     91.0    60
 21       218.8       60       215.6     98.5    50     209.9     95.9    50     201.4     92.0    50     195.0     89.1    60
 25       226.3       60       220.8     97.6    50     213.6     94.4    50     206.4     91.2    50     202.9     89.7    60
 29       236.3       55 (I)   226.4     95.8    50     218.9     92.6    50     213.3     90.3    50     205.3     86.9    54 (I)
 33       240.9       55       232.6     96.6    50     222.6     92.4    50     215.0     89.2    50     208.0     86.3    54
 37       252.4       54       240.7     95.4    50     230.5     91.3    50     222.0     88.0    50     211.6     83.8    54
 41       263.7       54       248.6     94.3    50     236.1     89.5    50     223.4     84.7    50     213.1     80.8    53
 45       274.0       54       256.6     93.6    50     242.8     88.6    49     229.9     83.9    50     214.5     78.3    52
 49       287.5       54       269.3     93.7    50     252.4     87.8    49     234.7     81.6    50     219.4     76.3    51
 53       293.2       49 (I)   280.0     95.5    49     254.7     86.9    49     239.8     81.8    50     224.8     76.7    46 (I)
 57       302.8       49       281.5     93.0    49     262.3     86.6    49     245.6     81.1    50     230.0     76.0    46
 61       311.8       48       293.1     94.0    49     269.0     86.3    49     247.0     79.2    50     239.3     76.7    46
 65       320.7       47       299.7     93.5    48     273.0     85.1    48     251.2     78.3    50     243.2     75.8    46
 69       325.7       45       304.3     93.4    47     276.2     84.8    48     250.9     77.0    50     253.7     77.9    44
 73       333.7       45       307.1     92.0    47     274.3     82.2    48     255.2     76.5    48     254.5     76.3    44
 77       335.6       45       313.6     93.4    46     276.8     82.5    46     255.7     76.2    46     256.9     76.5    42
 81       336.9       43       315.2     93.6    46     279.1     82.8    44     262.0     77.8    42     259.2     76.9    41
 85       346.4       42       319.6     92.3    43     283.7     81.9    44     269.3     77.7    39     265.0     76.5    40
 89       348.3       37       317.3     91.1    39     280.3     80.5    41     265.5     76.2    32     262.8     75.5    37
 93       349.5       32       316.2     90.5    36     278.5     79.7    37     259.2     74.2    27     258.8     74.0    31
 97       347.8       31       314.3     90.4    32     274.2     78.8    37     257.0     73.9    23     262.5     75.5    27
101       344.2       27       315.8     91.7    29     276.8     80.4    30     256.9     74.6    19     255.6     74.3    24

TERM. SAC.            22                         25                       22                       11                       16


===================================================================================================================================


    (A) NUMBER OF ANIMALS WEIGHED.  AT TERMINAL SACRIFICE, NUMBER
        OF ANIMALS ALIVE ON FIRST DAY OF TERMINAL SACRIFICE.
    (B) REFERS TO THE BEGINNING (INITIAL) BODY WEIGHT.
    (I) INTERIM SACRIFICE OCCURRED IN THIS WEEK.
    (*) THE NUMBER OF ANIMALS WEIGHED FOR THIS WEEK
         IS LESS THAN THE NUMBER OF ANIMALS SURVIVING.