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TDMS Study 05187-09 Pathology Tables

NTP Experiment-Test: 05187-09         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                           METHYLEUGENOL                                       Date: 07/20/98
Route: GAVAGE                                                                                                     Time: 08:56:31

                                                           CORE STUDY




       Facility:  Battelle Columbus Laboratory

       Chemical CAS #:  93-15-2

       Lock Date:  09/17/96

       Cage Range:  All

       Reasons For Removal:    25022 Accidently Killed                 25018 Dosing Accident
                               25019 Moribund Sacrifice                25020 Natural Death
                               25021 Terminal Sacrifice

       Removal Date Range:     All

       Treatment Groups:       Include All
































a  Number of animals examined microscopically at site and number of animals with lesion

                                                              Page   1


NTP Experiment-Test: 05187-09         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                           METHYLEUGENOL                                       Date: 07/20/98  
Route: GAVAGE                                                                                                     Time: 08:56:31  
____________________________________________________________________________________________________________________________________

         FISCHER 344 RATS FEMALE                   0 MG/KG      37 MG/KG     75 MG/KG     150          300                          
                                                                                          MG/KG        MG/KG                        
____________________________________________________________________________________________________________________________________

DISPOSITION SUMMARY                                                                                                                 


  Animals Initially In Study                          60           50           50           50           60                        
  Early Deaths                                                                                                                      
    Natural Death                                     11            9           13           12            9                        
    Moribund Sacrifice                                17           16           14           26           25                        
    Accidently Killed                                                            1                                                  
    Dosing Accident                                                                           1                                     
  Survivors                                                                                                                         
    Terminal Sacrifice                                22           25           22           11           16                        

  Animals Examined Microscopically                    50           50           50           50           50                        
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Intestine Large, Colon                             (50)         (50)         (50)         (50)         (50)                      
      Parasite Metazoan                                1 (2%)                                 1 (2%)                                
      Ulcer                                                                                   1 (2%)                                
   Intestine Large, Rectum                            (50)         (50)         (50)         (50)         (50)                      
      Parasite Metazoan                                2 (4%)       4 (8%)       2 (4%)       2 (4%)                                
   Intestine Large, Cecum                             (50)         (50)         (50)         (50)         (50)                      
      Lymphoid Tissue, Hyperplasia                                                            1 (2%)                                
   Intestine Small, Duodenum                          (50)         (50)         (50)         (50)         (50)                      
      Ulcer                                                         1 (2%)                                                          
   Liver                                              (50)         (50)         (49)         (49)         (50)                      
      Basophilic Focus                                36 (72%)     36 (72%)     29 (59%)     17 (35%)     10 (20%)                  
      Clear Cell Focus                                 3 (6%)      10 (20%)     12 (24%)      4 (8%)       7 (14%)                  
      Degeneration, Cystic, Focal                                                1 (2%)       4 (8%)      29 (58%)                  
      Eosinophilic Focus                              10 (20%)     20 (40%)     27 (55%)     31 (63%)     37 (74%)                  
      Hepatodiaphragmatic Nodule                       7 (14%)      2 (4%)       6 (12%)      2 (4%)       3 (6%)                   
      Inflammation, Granulomatous                                                                          1 (2%)                   
      Mixed Cell Focus                                 6 (12%)      4 (8%)      19 (39%)      9 (18%)      7 (14%)                  
      Necrosis, Focal                                               1 (2%)       1 (2%)                    1 (2%)                   
      Bile Duct, Cyst                                                                                      2 (4%)                   
      Bile Duct, Hyperplasia                          11 (22%)     11 (22%)     17 (35%)     22 (45%)     30 (60%)                  
      Centrilobular, Degeneration, Fatty                            3 (6%)                                                          
      Centrilobular, Necrosis                                                    1 (2%)       1 (2%)                                
      Centrilobular, Necrosis, Acute                                                                       1 (2%)                   
      Hepatocyte, Hypertrophy                          1 (2%)      13 (26%)     16 (33%)     26 (53%)     31 (62%)                  
      Oval Cell, Hyperplasia                           1 (2%)      15 (30%)     19 (39%)     35 (71%)     34 (68%)                  
      Periportal, Degeneration, Fatty                  1 (2%)                                                                       
   Mesentery                                          (6)          (5)          (3)          (3)          (3)                       
      Inflammation, Chronic                                                      1 (33%)                                            
      Artery, Inflammation, Chronic                    1 (17%)                                                                      
      Fat, Fibrosis                                                                                        1 (33%)                  
      Fat, Necrosis                                    5 (83%)      5 (100%)     2 (67%)      3 (100%)     2 (67%)                  
   Oral Mucosa                                                                  (1)                       (1)                       

a  Number of animals examined microscopically at site and number of animals with lesion                                             
NTP Experiment-Test: 05187-09         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                           METHYLEUGENOL                                       Date: 07/20/98  
Route: GAVAGE                                                                                                     Time: 08:56:31  
____________________________________________________________________________________________________________________________________

         FISCHER 344 RATS FEMALE                   0 MG/KG      37 MG/KG     75 MG/KG     150          300                          
                                                                                          MG/KG        MG/KG                        
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ALIMENTARY SYSTEM - CONT                                                                                                            
      Hyperplasia, Focal                                                                                   1 (100%)                 
   Pancreas                                           (50)         (50)         (50)         (49)         (50)                      
      Fibrosis                                                                   1 (2%)                                             
      Hyperplasia, Focal                                                                                   1 (2%)                   
      Acinus, Atrophy                                 10 (20%)     11 (22%)      8 (16%)      6 (12%)      4 (8%)                   
   Salivary Glands                                    (50)         (48)         (49)         (49)         (50)                      
      Submandibular Gland, Cytoplasmic Alteration      1 (2%)      48 (100%)    49 (100%)    49 (100%)    49 (98%)                  
   Stomach, Forestomach                               (50)         (49)         (50)         (50)         (50)                      
      Hyperkeratosis, Diffuse                          1 (2%)                                                                       
      Ulcer                                                         2 (4%)                                                          
   Stomach, Glandular                                 (50)         (50)         (50)         (48)         (49)                      
      Atrophy                                          3 (6%)      41 (82%)     45 (90%)     39 (81%)     33 (67%)                  
      Mineralization                                                             1 (2%)                                             
      Ulcer                                            3 (6%)       4 (8%)       4 (8%)                    3 (6%)                   
      Neuroendocrine Cell, Hyperplasia                              5 (10%)     11 (22%)      9 (19%)      3 (6%)                   
   Tongue                                             (1)          (1)                                                              
      Hyperkeratosis, Focal                            1 (100%)     1 (100%)                                                        
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Blood Vessel                                       (50)         (50)         (50)         (50)         (50)                      
      Aorta, Mineralization                                                                                1 (2%)                   
   Heart                                              (50)         (50)         (49)         (49)         (50)                      
      Degeneration, Mucoid                             1 (2%)                                                                       
      Atrium, Thrombosis                                            2 (4%)       1 (2%)                                             
      Myocardium, Degeneration                        35 (70%)     30 (60%)     26 (53%)     20 (41%)     27 (54%)                  
      Valve, Fibrosis                                  1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Cortex                                     (50)         (50)         (50)         (49)         (50)                      
      Hyperplasia, Focal                              13 (26%)     11 (22%)      7 (14%)      9 (18%)      5 (10%)                  
      Necrosis                                                      2 (4%)                    1 (2%)                                
      Bilateral, Hyperplasia                                                                               1 (2%)                   
   Adrenal Medulla                                    (50)         (50)         (50)         (49)         (50)                      
      Hyperplasia, Focal                               4 (8%)       9 (18%)      4 (8%)       3 (6%)       6 (12%)                  
      Infarct                                                       1 (2%)                                                          
   Islets, Pancreatic                                 (50)         (50)         (50)         (50)         (50)                      
      Hyperplasia                                      1 (2%)                                 1 (2%)                                
   Parathyroid Gland                                  (44)         (45)         (41)         (46)         (45)                      
      Hyperplasia                                                                                          3 (7%)                   
      Bilateral, Hyperplasia                                                     1 (2%)                                             
   Pituitary Gland                                    (50)         (50)         (50)         (50)         (49)                      
      Angiectasis                                      4 (8%)       2 (4%)       2 (4%)                    2 (4%)                   
      Cyst                                             3 (6%)       2 (4%)       4 (8%)       2 (4%)       3 (6%)                   

a  Number of animals examined microscopically at site and number of animals with lesion                                             
NTP Experiment-Test: 05187-09         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                           METHYLEUGENOL                                       Date: 07/20/98  
Route: GAVAGE                                                                                                     Time: 08:56:31  
____________________________________________________________________________________________________________________________________

         FISCHER 344 RATS FEMALE                   0 MG/KG      37 MG/KG     75 MG/KG     150          300                          
                                                                                          MG/KG        MG/KG                        
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ENDOCRINE SYSTEM - CONT                                                                                                             
      Pars Distalis, Hyperplasia, Diffuse                           1 (2%)                                                          
      Pars Distalis, Hyperplasia, Focal               11 (22%)     17 (34%)     14 (28%)     15 (30%)      6 (12%)                  
      Pars Intermedia, Hyperplasia, Focal                                                                  1 (2%)                   
      Rathke's Cleft, Cyst                             1 (2%)                                                                       
   Thyroid Gland                                      (50)         (49)         (49)         (50)         (48)                      
      Inflammation, Focal, Suppurative                              1 (2%)                                                          
      C-Cell, Hyperplasia                             32 (64%)     33 (67%)     30 (61%)     32 (64%)     32 (67%)                  
      Follicle, Cyst                                   1 (2%)                                              1 (2%)                   
      Follicular Cell, Hyperplasia, Focal                           1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Clitoral Gland                                     (48)         (46)         (49)         (46)         (48)                      
      Cyst                                             2 (4%)       1 (2%)       2 (4%)       1 (2%)                                
      Hyperplasia, Focal                               2 (4%)       3 (7%)       1 (2%)                    1 (2%)                   
      Inflammation, Chronic                                         1 (2%)                                                          
      Inflammation, Suppurative                                                  1 (2%)                                             
      Necrosis, Focal                                  1 (2%)                                                                       
   Ovary                                              (50)         (50)         (49)         (49)         (50)                      
      Cyst                                             2 (4%)       7 (14%)      2 (4%)       2 (4%)       4 (8%)                   
   Uterus                                             (50)         (50)         (49)         (50)         (50)                      
      Hyperplasia, Cystic                              2 (4%)                                                                       
      Cervix, Hyperplasia, Focal                                                              1 (2%)                                
      Endometrium, Degeneration                                                  1 (2%)                                             
      Endometrium, Hyperplasia, Cystic                                                                     1 (2%)                   
   Vagina                                                          (2)                       (2)                                    
      Infiltration Cellular, Polymorphonuclear                      1 (50%)                                                         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (50)         (50)         (49)         (50)         (50)                      
      Fibrosis                                         2 (4%)                    2 (4%)       2 (4%)       4 (8%)                   
      Hyperplasia                                      4 (8%)      15 (30%)     11 (22%)     20 (40%)     25 (50%)                  
      Inflammation, Granulomatous                                   2 (4%)                                                          
      Necrosis                                                      1 (2%)                    2 (4%)                                
      Erythroid Cell, Hyperplasia                                                1 (2%)                                             
      Myeloid Cell, Hyperplasia                        1 (2%)       2 (4%)                                                          
   Lymph Node                                         (2)          (5)          (1)          (10)         (6)                       
      Pancreatic, Erythrophagocytosis                  1 (50%)                                                                      
      Pancreatic, Hyperplasia                                                                 1 (10%)                               

a  Number of animals examined microscopically at site and number of animals with lesion                                             
NTP Experiment-Test: 05187-09         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                           METHYLEUGENOL                                       Date: 07/20/98  
Route: GAVAGE                                                                                                     Time: 08:56:31  
____________________________________________________________________________________________________________________________________

         FISCHER 344 RATS FEMALE                   0 MG/KG      37 MG/KG     75 MG/KG     150          300                          
                                                                                          MG/KG        MG/KG                        
____________________________________________________________________________________________________________________________________
                                                                                                                                    
HEMATOPOIETIC SYSTEM - CONT                                                                                                         
      Pancreatic, Necrosis                                          1 (20%)                                                         
      Renal, Ectasia                                                                          1 (10%)                               
      Renal, Inflammation, Granulomatous                                                                   1 (17%)                  
   Lymph Node, Mandibular                             (49)         (48)         (49)         (49)         (48)                      
      Necrosis                                                                                1 (2%)                                
   Lymph Node, Mesenteric                             (50)         (49)         (49)         (49)         (50)                      
      Erythrophagocytosis                              1 (2%)                                                                       
      Inflammation, Granulomatous                                                             1 (2%)                                
      Necrosis                                                                                1 (2%)                                
   Spleen                                             (50)         (50)         (50)         (49)         (50)                      
      Fibrosis                                         3 (6%)       3 (6%)       5 (10%)     12 (24%)     15 (30%)                  
      Hematopoietic Cell Proliferation                              7 (14%)      6 (12%)      2 (4%)      12 (24%)                  
      Inflammation, Focal, Suppurative                                           1 (2%)                                             
      Inflammation, Granulomatous                                   2 (4%)       1 (2%)       1 (2%)                                
      Necrosis                                                      1 (2%)                                                          
      Lymphoid Follicle, Hyperplasia                                             1 (2%)                                             
      Red Pulp, Necrosis                                                                      2 (4%)                                
   Thymus                                             (49)         (48)         (46)         (46)         (49)                      
      Atrophy                                                                    1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Mammary Gland                                      (50)         (50)         (50)         (50)         (50)                      
      Dilatation                                      27 (54%)     22 (44%)     34 (68%)     20 (40%)     10 (20%)                  
      Galactocele                                     10 (20%)     10 (20%)      7 (14%)      6 (12%)      5 (10%)                  
      Hyperplasia, Cystic                                           2 (4%)       2 (4%)                                             
      Hyperplasia, Focal                               8 (16%)      7 (14%)      9 (18%)      2 (4%)       2 (4%)                   
      Hyperplasia, Lobular                                          1 (2%)                                                          
      Inflammation, Suppurative                                                  1 (2%)                                             
   Skin                                               (50)         (50)         (50)         (50)         (50)                      
      Ulcer                                                                      1 (2%)                                             
      Dermis, Necrosis                                                           1 (2%)                                             
      Dermis, Subcutaneous Tissue, Fibrosis            1 (2%)                    1 (2%)                                             
      Hair Follicle, Atrophy, Focal                                              1 (2%)       1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Bone                                               (50)         (50)         (50)         (50)         (50)                      
      Fibrous Osteodystrophy                                                                               3 (6%)                   
      Hyperostosis                                     1 (2%)       1 (2%)       5 (10%)      4 (8%)       2 (4%)                   
      Osteopetrosis                                                 1 (2%)       2 (4%)                                             
   Skeletal Muscle                                                 (1)                       (1)          (1)                       
      Degeneration, Focal                                                                     1 (100%)                              
      Fibrosis                                                                                             1 (100%)                 
____________________________________________________________________________________________________________________________________

a  Number of animals examined microscopically at site and number of animals with lesion                                             
NTP Experiment-Test: 05187-09         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                           METHYLEUGENOL                                       Date: 07/20/98  
Route: GAVAGE                                                                                                     Time: 08:56:31  
____________________________________________________________________________________________________________________________________

         FISCHER 344 RATS FEMALE                   0 MG/KG      37 MG/KG     75 MG/KG     150          300                          
                                                                                          MG/KG        MG/KG                        
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (50)         (50)         (50)         (50)         (50)                      
      Congestion, Focal                                                                       1 (2%)                                
      Hydrocephalus                                    4 (8%)       9 (18%)      3 (6%)       8 (16%)      9 (18%)                  
      Cerebellum, Necrosis, Focal                                                             1 (2%)                                
      Hypothalamus, Degeneration                       9 (18%)     12 (24%)      6 (12%)      7 (14%)      5 (10%)                  
      Medulla, Degeneration                            1 (2%)                                                                       
      Pons, Degeneration                                                                      1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (50)         (50)         (49)         (49)         (50)                      
      Inflammation, Acute                              1 (2%)                    2 (4%)                                             
      Inflammation, Chronic                                         1 (2%)                                                          
      Inflammation, Granulomatous                      1 (2%)                    1 (2%)                    2 (4%)                   
      Alveolar Epithelium, Hyperplasia, Focal          2 (4%)       3 (6%)       7 (14%)      3 (6%)       5 (10%)                  
      Interstitium, Inflammation, Chronic                           1 (2%)                                 1 (2%)                   
      Interstitium, Mineralization                                                                         2 (4%)                   
   Nose                                               (50)         (50)         (50)         (50)         (50)                      
      Hyperplasia, Squamous                                         1 (2%)                                                          
      Inflammation, Suppurative                        8 (16%)     10 (20%)     14 (28%)      3 (6%)       3 (6%)                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Eye                                                (1)                       (2)                                                 
      Cataract                                         1 (100%)                  1 (50%)                                            
      Degeneration                                                               1 (50%)                                            
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (50)         (50)         (50)         (49)         (50)                      
      Hydronephrosis                                                2 (4%)                                                          
      Infarct                                                       3 (6%)       1 (2%)                                             
      Inflammation, Focal, Suppurative                                           1 (2%)                                             
      Necrosis                                         1 (2%)                                                                       
      Nephropathy                                     35 (70%)     42 (84%)     41 (82%)     44 (90%)     45 (90%)                  
      Renal Tubule, Accumulation, Hyaline Droplet                   1 (2%)                                                          
      Renal Tubule, Pigmentation, Lipofuscin           1 (2%)       1 (2%)       4 (8%)       3 (6%)                                
                                                                                                                                    

a  Number of animals examined microscopically at site and number of animals with lesion                                             
NTP Experiment-Test: 05187-09         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                           METHYLEUGENOL                                       Date: 07/20/98  
Route: GAVAGE                                                                                                     Time: 08:56:31  
____________________________________________________________________________________________________________________________________

         FISCHER 344 RATS MALE                     0 MG/KG      37 MG/KG     75 MG/KG     150          300                          
                                                                                          MG/KG        MG/KG                        
____________________________________________________________________________________________________________________________________

DISPOSITION SUMMARY                                                                                                                 


  Animals Initially In Study                          60           50           50           50           60                        
  Early Deaths                                                                                                                      
    Natural Death                                     15           15           17           29           26                        
    Moribund Sacrifice                                15           18           15           20           23                        
    Dosing Accident                                                 1            3            1            1                        
  Survivors                                                                                                                         
    Terminal Sacrifice                                20           16           15                                                  

  Animals Examined Microscopically                    50           50           50           50           50                        
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Esophagus                                          (50)         (50)         (50)         (50)         (48)                      
      Perforation                                                                1 (2%)       1 (2%)                                
      Periesophageal Tissue, Inflammation                                        1 (2%)                    1 (2%)                   
   Intestine Large, Colon                             (50)         (50)         (50)         (50)         (50)                      
      Fibrosis                                                                                             1 (2%)                   
      Mineralization                                                                                       4 (8%)                   
      Necrosis                                                                                             1 (2%)                   
      Parasite Metazoan                                1 (2%)       2 (4%)       5 (10%)      1 (2%)       1 (2%)                   
   Intestine Large, Rectum                            (49)         (49)         (49)         (50)         (50)                      
      Parasite Metazoan                                1 (2%)       3 (6%)       5 (10%)      4 (8%)       1 (2%)                   
   Intestine Large, Cecum                             (50)         (50)         (50)         (50)         (49)                      
      Ulcer                                            1 (2%)                                                                       
   Intestine Small, Duodenum                          (50)         (50)         (50)         (50)         (49)                      
      Ulcer                                            3 (6%)       1 (2%)                                                          
      Peyer's Patch, Hyperplasia                       1 (2%)                                                                       
   Intestine Small, Jejunum                           (50)         (50)         (50)         (50)         (50)                      
      Inflammation, Chronic, Focal                                  1 (2%)                    1 (2%)                                
   Intestine Small, Ileum                             (50)         (49)         (50)         (50)         (49)                      
      Mineralization                                                                          1 (2%)                                
      Ulcer                                            1 (2%)                                                                       
   Liver                                              (50)         (50)         (50)         (50)         (50)                      
      Basophilic Focus                                23 (46%)     21 (42%)     22 (44%)      7 (14%)      6 (12%)                  
      Clear Cell Focus                                 4 (8%)       3 (6%)       7 (14%)      3 (6%)       3 (6%)                   
      Degeneration, Cystic, Focal                      4 (8%)       2 (4%)      25 (50%)     38 (76%)     41 (82%)                  
      Degeneration, Fatty, Focal                       1 (2%)                                                                       
      Eosinophilic Focus                              11 (22%)     28 (56%)     43 (86%)     47 (94%)     39 (78%)                  
      Hepatodiaphragmatic Nodule                       4 (8%)       1 (2%)                                                          
      Inflammation, Acute                              1 (2%)                                 1 (2%)                                
      Mixed Cell Focus                                 1 (2%)       7 (14%)     14 (28%)      8 (16%)      2 (4%)                   
      Necrosis, Focal                                  2 (4%)       2 (4%)       5 (10%)      3 (6%)       2 (4%)                   
      Bile Duct, Cyst                                                                                      1 (2%)                   
      Bile Duct, Hyperplasia                          36 (72%)     17 (34%)     16 (32%)     17 (34%)     28 (56%)                  
      Bile Duct, Hyperplasia, Atypical, Focal                                    1 (2%)       2 (4%)       1 (2%)                   

a  Number of animals examined microscopically at site and number of animals with lesion                                             
NTP Experiment-Test: 05187-09         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                           METHYLEUGENOL                                       Date: 07/20/98  
Route: GAVAGE                                                                                                     Time: 08:56:31  
____________________________________________________________________________________________________________________________________

         FISCHER 344 RATS MALE                     0 MG/KG      37 MG/KG     75 MG/KG     150          300                          
                                                                                          MG/KG        MG/KG                        
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ALIMENTARY SYSTEM - CONT                                                                                                            
      Centrilobular, Degeneration                      6 (12%)      1 (2%)                                                          
      Centrilobular, Degeneration, Fatty               2 (4%)                    1 (2%)                                             
      Centrilobular, Necrosis                          1 (2%)       4 (8%)                    1 (2%)       1 (2%)                   
      Hepatocyte, Hypertrophy                                      13 (26%)     25 (50%)     30 (60%)     26 (52%)                  
      Oval Cell, Hyperplasia                          14 (28%)     17 (34%)     24 (48%)     34 (68%)     27 (54%)                  
   Mesentery                                          (5)          (6)                       (1)          (1)                       
      Fat, Necrosis                                    5 (100%)     6 (100%)                                                        
   Pancreas                                           (50)         (50)         (50)         (50)         (49)                      
      Atrophy, Acute                                   1 (2%)                                                                       
      Hyperplasia, Focal                               3 (6%)       2 (4%)       1 (2%)       2 (4%)       2 (4%)                   
      Acinus, Atrophy                                 20 (40%)     15 (30%)     13 (26%)      9 (18%)     10 (20%)                  
      Acinus, Hyperplasia, Focal                       1 (2%)       1 (2%)                                                          
      Artery, Inflammation, Chronic                    4 (8%)                                                                       
   Salivary Glands                                    (50)         (50)         (50)         (48)         (48)                      
      Inflammation, Chronic                                                                   1 (2%)                                
      Parotid Gland, Atrophy                                                     1 (2%)                                             
      Submandibular Gland, Cytoplasmic Alteration      4 (8%)      50 (100%)    49 (98%)     48 (100%)    48 (100%)                 
      Submandibular Gland, Fibrosis                                              1 (2%)                                             
   Stomach, Forestomach                               (50)         (50)         (50)         (50)         (49)                      
      Hyperkeratosis                                                             1 (2%)                                             
      Hyperkeratosis, Focal                            1 (2%)                                                                       
      Inflammation, Chronic                                                                   1 (2%)                                
      Mineralization                                   3 (6%)                    1 (2%)       6 (12%)      5 (10%)                  
      Ulcer                                            7 (14%)      1 (2%)                                 1 (2%)                   
   Stomach, Glandular                                 (50)         (50)         (50)         (50)         (49)                      
      Atrophy                                                      14 (28%)     32 (64%)     37 (74%)     29 (59%)                  
      Inflammation, Focal, Suppurative                 2 (4%)       3 (6%)                                 1 (2%)                   
      Mineralization                                  10 (20%)      4 (8%)      15 (30%)     14 (28%)     20 (41%)                  
      Ulcer                                            4 (8%)       2 (4%)       3 (6%)       2 (4%)       8 (16%)                  
      Neuroendocrine Cell, Hyperplasia                                           1 (2%)       8 (16%)      8 (16%)                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Blood Vessel                                       (50)         (50)         (50)         (50)         (50)                      
      Mineralization                                   1 (2%)       2 (4%)       3 (6%)       7 (14%)      9 (18%)                  
      Aorta, Hyperplasia                                                                                   1 (2%)                   
      Aorta, Mineralization                            5 (10%)                   9 (18%)      6 (12%)     10 (20%)                  
   Heart                                              (50)         (50)         (50)         (50)         (49)                      
      Inflammation, Focal, Suppurative                              1 (2%)                                 1 (2%)                   
      Atrium, Thrombosis                               6 (12%)      5 (10%)      4 (8%)       2 (4%)                                
      Endocardium, Fibrosis                                         1 (2%)                                                          
      Myocardium, Degeneration                        45 (90%)     41 (82%)     34 (68%)     37 (74%)     25 (51%)                  
      Myocardium, Mineralization                       5 (10%)      2 (4%)      11 (22%)      9 (18%)     15 (31%)                  
      Valve, Inflammation, Chronic                                                            1 (2%)                                
      Valve, Thrombosis                                             1 (2%)                                                          
      Ventricle, Thrombosis                                                                   1 (2%)                                

a  Number of animals examined microscopically at site and number of animals with lesion                                             
NTP Experiment-Test: 05187-09         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                           METHYLEUGENOL                                       Date: 07/20/98  
Route: GAVAGE                                                                                                     Time: 08:56:31  
____________________________________________________________________________________________________________________________________

         FISCHER 344 RATS MALE                     0 MG/KG      37 MG/KG     75 MG/KG     150          300                          
                                                                                          MG/KG        MG/KG                        
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Cortex                                     (50)         (50)         (50)         (50)         (50)                      
      Hyperplasia, Focal                              13 (26%)     12 (24%)      6 (12%)      4 (8%)       5 (10%)                  
      Necrosis                                         1 (2%)       1 (2%)                                                          
      Necrosis, Focal                                                                         1 (2%)       1 (2%)                   
      Vacuolization Cytoplasmic, Focal                                                                     1 (2%)                   
   Adrenal Medulla                                    (50)         (50)         (50)         (50)         (50)                      
      Hematocyst                                                                 1 (2%)                                             
      Hyperplasia                                                   1 (2%)                                                          
      Hyperplasia, Focal                              16 (32%)     20 (40%)     21 (42%)     21 (42%)     14 (28%)                  
   Islets, Pancreatic                                 (50)         (50)         (50)         (50)         (49)                      
      Hyperplasia                                                   4 (8%)       1 (2%)                                             
   Parathyroid Gland                                  (48)         (49)         (48)         (45)         (46)                      
      Hyperplasia                                      7 (15%)      2 (4%)       6 (13%)      3 (7%)       7 (15%)                  
      Hyperplasia, Focal                               2 (4%)                                              1 (2%)                   
      Bilateral, Hyperplasia                          10 (21%)      6 (12%)     16 (33%)     18 (40%)     18 (39%)                  
   Pituitary Gland                                    (50)         (50)         (50)         (50)         (50)                      
      Angiectasis                                      2 (4%)                                 2 (4%)                                
      Cyst                                                                                                 1 (2%)                   
      Hyperplasia, Focal                                                         1 (2%)                                             
      Pars Distalis, Hyperplasia, Focal               12 (24%)      9 (18%)      8 (16%)      2 (4%)       1 (2%)                   
      Pars Intermedia, Hyperplasia, Focal                                                                  1 (2%)                   
      Pars Nervosa, Inflammation, Focal,                                                                                            
          Suppurative                                                                         1 (2%)                                
      Rathke's Cleft, Cyst                                                       1 (2%)                                             
   Thyroid Gland                                      (50)         (50)         (50)         (48)         (48)                      
      C-Cell, Hyperplasia                             22 (44%)     25 (50%)     25 (50%)     10 (21%)     17 (35%)                  
      Follicle, Cyst                                   1 (2%)       1 (2%)                                 1 (2%)                   
      Follicular Cell, Hyperplasia, Focal                                                                  1 (2%)                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Epididymis                                         (50)         (49)         (49)         (50)         (50)                      
      Fibrosis                                                                   1 (2%)                                             
      Granuloma Sperm                                                                         1 (2%)       1 (2%)                   
      Serosa, Hyperplasia, Mesothelium                                                                     2 (4%)                   
   Preputial Gland                                    (50)         (50)         (49)         (50)         (50)                      
      Cyst                                             5 (10%)      2 (4%)                    6 (12%)      4 (8%)                   
      Fibrosis                                                                                             1 (2%)                   
      Hyperplasia, Focal                               3 (6%)       4 (8%)       6 (12%)      4 (8%)       5 (10%)                  

a  Number of animals examined microscopically at site and number of animals with lesion                                             
NTP Experiment-Test: 05187-09         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                           METHYLEUGENOL                                       Date: 07/20/98  
Route: GAVAGE                                                                                                     Time: 08:56:31  
____________________________________________________________________________________________________________________________________

         FISCHER 344 RATS MALE                     0 MG/KG      37 MG/KG     75 MG/KG     150          300                          
                                                                                          MG/KG        MG/KG                        
____________________________________________________________________________________________________________________________________
                                                                                                                                    
GENITAL SYSTEM - CONT                                                                                                               
      Inflammation, Chronic                            9 (18%)     14 (28%)      8 (16%)     12 (24%)      4 (8%)                   
      Inflammation, Chronic Active                                  1 (2%)                                                          
   Prostate                                           (50)         (50)         (49)         (49)         (49)                      
      Hyperplasia                                                                1 (2%)       1 (2%)                                
      Hyperplasia, Focal                                            1 (2%)                    1 (2%)                                
      Inflammation, Chronic                           16 (32%)     18 (36%)     13 (27%)     15 (31%)      9 (18%)                  
   Seminal Vesicle                                    (50)         (50)         (50)         (50)         (50)                      
      Inflammation, Suppurative                                     1 (2%)       2 (4%)       6 (12%)      3 (6%)                   
      Mineralization                                                             1 (2%)                    3 (6%)                   
      Epithelium, Atrophy                                                                     1 (2%)                                
      Serosa, Hyperplasia, Mesothelium                                                                     1 (2%)                   
   Testes                                             (50)         (49)         (49)         (50)         (50)                      
      Atrophy                                                                                              1 (2%)                   
      Germinal Epithelium, Atrophy                     3 (6%)       1 (2%)                    3 (6%)       1 (2%)                   
      Interstitial Cell, Hyperplasia                   3 (6%)                                              1 (2%)                   
      Tunic, Hyperplasia, Mesothelium                                                                      3 (6%)                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (50)         (50)         (50)         (50)         (50)                      
      Fibrosis                                         3 (6%)                    2 (4%)                                             
      Hyperplasia                                     18 (36%)     14 (28%)     22 (44%)     23 (46%)     18 (36%)                  
      Necrosis                                                      2 (4%)       2 (4%)       1 (2%)       1 (2%)                   
   Lymph Node                                         (8)          (4)          (4)          (4)          (3)                       
      Lumbar, Hyperplasia, Lymphoid                                                           1 (25%)                               
      Mediastinal, Erythrophagocytosis                                                        1 (25%)      1 (33%)                  
      Mediastinal, Hyperplasia, Lymphoid               2 (25%)                                                                      
      Mediastinal, Inflammation, Suppurative                                     1 (25%)                                            
   Lymph Node, Mesenteric                             (50)         (50)         (49)         (50)         (48)                      
      Ectasia                                          1 (2%)                                                                       
      Erythrophagocytosis                                                                     1 (2%)                                
      Inflammation, Suppurative                                                  1 (2%)                                             
   Spleen                                             (50)         (50)         (50)         (50)         (49)                      
      Congestion                                                    1 (2%)       1 (2%)       1 (2%)                                
      Fibrosis                                         8 (16%)     11 (22%)     12 (24%)     12 (24%)      4 (8%)                   
      Hematopoietic Cell Proliferation                 2 (4%)       9 (18%)      2 (4%)      13 (26%)      4 (8%)                   
      Hemorrhage                                                                              1 (2%)                                
      Metaplasia, Lipocyte                             1 (2%)                                                                       
      Lymphoid Follicle, Atrophy                                                                           1 (2%)                   
      Lymphoid Follicle, Depletion Cellular            1 (2%)                                                                       
   Thymus                                             (46)         (45)         (43)         (42)         (43)                      
      Cyst                                             1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    

a  Number of animals examined microscopically at site and number of animals with lesion                                             
NTP Experiment-Test: 05187-09         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                           METHYLEUGENOL                                       Date: 07/20/98  
Route: GAVAGE                                                                                                     Time: 08:56:31  
____________________________________________________________________________________________________________________________________

         FISCHER 344 RATS MALE                     0 MG/KG      37 MG/KG     75 MG/KG     150          300                          
                                                                                          MG/KG        MG/KG                        
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Mammary Gland                                      (50)         (49)         (49)         (45)         (46)                      
      Dilatation                                      13 (26%)     13 (27%)      4 (8%)       7 (16%)      1 (2%)                   
      Galactocele                                      1 (2%)                                              1 (2%)                   
      Hyperplasia, Focal                                            1 (2%)                    1 (2%)                                
      Duct, Granuloma                                  1 (2%)                                                                       
   Skin                                               (50)         (50)         (50)         (50)         (50)                      
      Cyst Epithelial Inclusion                        1 (2%)                                                                       
      Edema                                                                                   1 (2%)                                
      Ulcer                                            2 (4%)                                              1 (2%)                   
      Dermis, Inflammation, Focal, Suppurative                      1 (2%)                                                          
      Pinna, Ulcer                                                                                         1 (2%)                   
      Subcutaneous Tissue, Fibrosis                    1 (2%)                                                                       
      Subcutaneous Tissue, Necrosis                                              1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Bone                                               (50)         (50)         (50)         (50)         (50)                      
      Fibrous Osteodystrophy                           8 (16%)      2 (4%)      12 (24%)     14 (28%)     21 (42%)                  
      Osteopetrosis                                    1 (2%)       2 (4%)                                                          
      Cranium, Hyperostosis                                                                                1 (2%)                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (50)         (50)         (50)         (50)         (50)                      
      Degeneration, Focal                              1 (2%)                                                                       
      Hydrocephalus                                    2 (4%)       3 (6%)       3 (6%)       1 (2%)       1 (2%)                   
      Necrosis                                         1 (2%)                                                                       
      Necrosis, Focal                                               2 (4%)       1 (2%)       1 (2%)                                
      Hypothalamus, Degeneration                                    1 (2%)       1 (2%)                                             
   Spinal Cord                                        (1)          (1)          (1)                                                 
      Axon, Degeneration, Focal                        1 (100%)                                                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (50)         (50)         (50)         (50)         (49)                      
      Congestion                                                                                           1 (2%)                   
      Erythrophagocytosis                                           1 (2%)                                                          
      Hemorrhage, Focal                                                          1 (2%)                                             
      Infiltration Cellular, Histiocyte                1 (2%)                    1 (2%)                                             
      Inflammation, Granulomatous                      2 (4%)                    2 (4%)       3 (6%)       2 (4%)                   
      Inflammation, Suppurative                        1 (2%)       3 (6%)       2 (4%)       1 (2%)                                
      Alveolar Epithelium, Hyperplasia, Focal                       1 (2%)       1 (2%)       2 (4%)       1 (2%)                   
      Alveolar Epithelium, Interstitium,                                                                                            

a  Number of animals examined microscopically at site and number of animals with lesion                                             
NTP Experiment-Test: 05187-09         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                           METHYLEUGENOL                                       Date: 07/20/98  
Route: GAVAGE                                                                                                     Time: 08:56:31  
____________________________________________________________________________________________________________________________________

         FISCHER 344 RATS MALE                     0 MG/KG      37 MG/KG     75 MG/KG     150          300                          
                                                                                          MG/KG        MG/KG                        
____________________________________________________________________________________________________________________________________
                                                                                                                                    
RESPIRATORY SYSTEM - CONT                                                                                                           
          Mineralization                                                         1 (2%)       1 (2%)                                
      Bronchiole, Inflammation, Suppurative                                      1 (2%)                                             
      Bronchus, Inflammation, Suppurative                                                     1 (2%)                                
      Interstitium, Inflammation, Chronic              2 (4%)       1 (2%)       2 (4%)       1 (2%)       1 (2%)                   
      Interstitium, Mineralization                     4 (8%)       1 (2%)       8 (16%)     10 (20%)     18 (37%)                  
      Perivascular, Edema                                           1 (2%)       1 (2%)                                             
      Vein, Thrombosis                                 1 (2%)                                                                       
   Nose                                               (50)         (50)         (50)         (50)         (50)                      
      Inflammation, Suppurative                       11 (22%)     14 (28%)     20 (40%)     11 (22%)      9 (18%)                  
   Trachea                                            (50)         (50)         (50)         (49)         (48)                      
      Inflammation                                                                                         1 (2%)                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Eye                                                (1)          (1)          (2)          (1)                                    
      Cataract                                         1 (100%)                  1 (50%)      1 (100%)                              
      Degeneration                                                               1 (50%)                                            
      Cornea, Inflammation, Chronic                                 1 (100%)                                                        
      Retina, Atrophy                                                            1 (50%)                                            
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (50)         (50)         (50)         (50)         (50)                      
      Hydronephrosis                                                             2 (4%)                    1 (2%)                   
      Inflammation, Focal, Suppurative                              1 (2%)       1 (2%)       2 (4%)       1 (2%)                   
      Nephropathy                                     49 (98%)     46 (92%)     48 (96%)     50 (100%)    47 (94%)                  
      Renal Tubule, Cyst                                            2 (4%)                                 2 (4%)                   
      Renal Tubule, Hyperplasia, Focal                 5 (10%)      1 (2%)       7 (14%)      4 (8%)       3 (6%)                   
      Renal Tubule, Hyperplasia, Oncocytic                                                    2 (4%)       1 (2%)                   
   Urinary Bladder                                    (49)         (50)         (49)         (49)         (50)                      
      Inflammation, Suppurative                                                                            1 (2%)                   
      Ulcer                                            1 (2%)       1 (2%)       2 (4%)                                             
      Transitional Epithelium, Hyperplasia             1 (2%)                                              1 (2%)                   
                                                                                                                                    

a  Number of animals examined microscopically at site and number of animals with lesion                                             
                             ------------------------------------------------------------                                           
                             ----------              END OF REPORT             ----------                                           
                             ------------------------------------------------------------