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TDMS Study 05187-09 Pathology Tables

NTP Experiment-Test: 05187-09                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           METHYLEUGENOL                                       Date: 07/20/98
Route: GAVAGE                                                                                                     Time: 09:02:53

                                                           CORE STUDY




       Facility:  Battelle Columbus Laboratory

       Chemical CAS #:  93-15-2

       Lock Date:  09/17/96

       Cage Range:  All

       Reasons For Removal:    25022 Accidently Killed                 25018 Dosing Accident
                               25019 Moribund Sacrifice                25020 Natural Death
                               25021 Terminal Sacrifice

       Removal Date Range:     All

       Treatment Groups:       Include All


































                                                              Page   1



NTP Experiment-Test: 05187-09                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           METHYLEUGENOL                                       Date: 07/20/98  
Route: GAVAGE                                                                                                     Time: 09:02:53  
                                                                                                                                    

 _____________________________________________________________________________________________________________________              
                                           | 5| 4| 7| 7| 5| 6| 7| 6| 6| 6| 7| 7| 7| 5| 7| 5| 6| 7| 6| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 4| 4| 3| 0| 9| 4| 3| 4| 1| 4| 3| 3| 3| 9| 1| 5| 0| 3| 8| 3| 3| 3| 2| 3| 3|             
                                           | 9| 8| 0| 0| 8| 1| 1| 4| 6| 1| 1| 0| 1| 8| 7| 5| 9| 0| 3| 0| 1| 1| 4| 0| 1|             

 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    0 MG/KG                                | 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9|             
                                           | 1| 2| 3| 4| 5| 6| 8| 9| 0| 1| 2| 3| 4| 5| 8| 9| 0| 1| 2| 4| 5| 6| 7| 8| 9|             

 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Parasite Metazoan                    |                                                                          |             

                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Parasite Metazoan                    |                                                                          |             

                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Basophilic Focus                     |       X           X        X  X  X     X  X     X  X  X  X  X  X  X  X  X|             
      Clear Cell Focus                     | X                    X                                                   |             
      Eosinophilic Focus                   |          X                                         X  X     X  X        X|             
      Hepatodiaphragmatic Nodule           |                      X     X           X                                 |             
      Mixed Cell Focus                     |          X        X                                   X           X      |             
      Bile Duct, Hyperplasia               |          1        1  1                             1     1              1|             
      Hepatocyte, Hypertrophy              |                                                    2                     |             
      Oval Cell, Hyperplasia               |                                                    1                     |             
      Periportal, Degeneration, Fatty      |                      2                                                   |             

                                            __________________________________________________________________________|             
   Mesentery                               |             +                          +  +     +        +               |             
      Artery, Inflammation, Chronic        |             4                                                            |             
      Fat, Necrosis                        |                                        3  3     2        2               |             

                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Acinus, Atrophy                      |          4                 1     1           3                           |             

                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Submandibular Gland, Cytoplasmic     |                                                                          |             
          Alteration                       |                                              2                           |             

                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperkeratosis, Diffuse              |                                                                          |             

                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                                              1                           |             
      Ulcer                                |             1                                      1                     |             

                                            __________________________________________________________________________|             
   Tongue                                  |                                                       +                  |             
      Hyperkeratosis, Focal                |                                                       2                  |             

 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Blood Vessel                            | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Degeneration, Mucoid                 |                                                                          |             
      Myocardium, Degeneration             | 1        2  1  1  1  1  1  2  1  1        1  1  1  1     1  1     1  1  1|             
      Valve, Fibrosis                      |                         2                                                |             

 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

 _____________________________________________________________________________________________________________________|             
NTP Experiment-Test: 05187-09                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           METHYLEUGENOL                                       Date: 07/20/98  
Route: GAVAGE                                                                                                     Time: 09:02:53  
                                                                                                                                    

 _____________________________________________________________________________________________________________________              
                                           | 5| 4| 7| 7| 5| 6| 7| 6| 6| 6| 7| 7| 7| 5| 7| 5| 6| 7| 6| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 4| 4| 3| 0| 9| 4| 3| 4| 1| 4| 3| 3| 3| 9| 1| 5| 0| 3| 8| 3| 3| 3| 2| 3| 3|             
                                           | 9| 8| 0| 0| 8| 1| 1| 4| 6| 1| 1| 0| 1| 8| 7| 5| 9| 0| 3| 0| 1| 1| 4| 0| 1|             

 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    0 MG/KG                                | 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9|             
                                           | 1| 2| 3| 4| 5| 6| 8| 9| 0| 1| 2| 3| 4| 5| 8| 9| 0| 1| 2| 4| 5| 6| 7| 8| 9|             

 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
      Hyperplasia, Focal                   |                                        1                 1  2     1      |             

                                            __________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Focal                   |                1                    3           2                        |             

                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                         1                                                |             

                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  M  +  M  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  M|             

                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                3     3  3                                                |             
      Cyst                                 |       3                       3                                          |             
      Pars Distalis, Hyperplasia, Focal    |                                  1                 2           1         |             
      Rathke's Cleft, Cyst                 |                                                                          |             

                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      C-Cell, Hyperplasia                  |       2     3  2  2        2  2  1     1     2  2  3  3  3     2  2  2  1|             
      Follicle, Cyst                       |                                                                         1|             

 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             

 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Clitoral Gland                          | +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                                                          |             
      Hyperplasia, Focal                   |                                           3                              |             
      Necrosis, Focal                      |                                                                          |             

                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                         3              3                                 |             

                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Cystic                  | 1                                         2                              |             

 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrosis                             |                2                                                         |             
      Hyperplasia                          | 2                                                  2     2              1|             
      Myeloid Cell, Hyperplasia            |                3                                                         |             

                                            __________________________________________________________________________|             
   Lymph Node                              |                                                                          |             
      Pancreatic, Erythrophagocytosis      |                                                                          |             

                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Erythrophagocytosis                  |                                           2                              |             

                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrosis                             |                            2                                            1|             

                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

 _____________________________________________________________________________________________________________________|             
NTP Experiment-Test: 05187-09                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           METHYLEUGENOL                                       Date: 07/20/98  
Route: GAVAGE                                                                                                     Time: 09:02:53  
                                                                                                                                    

 _____________________________________________________________________________________________________________________              
                                           | 5| 4| 7| 7| 5| 6| 7| 6| 6| 6| 7| 7| 7| 5| 7| 5| 6| 7| 6| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 4| 4| 3| 0| 9| 4| 3| 4| 1| 4| 3| 3| 3| 9| 1| 5| 0| 3| 8| 3| 3| 3| 2| 3| 3|             
                                           | 9| 8| 0| 0| 8| 1| 1| 4| 6| 1| 1| 0| 1| 8| 7| 5| 9| 0| 3| 0| 1| 1| 4| 0| 1|             

 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    0 MG/KG                                | 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9|             
                                           | 1| 2| 3| 4| 5| 6| 8| 9| 0| 1| 2| 3| 4| 5| 8| 9| 0| 1| 2| 4| 5| 6| 7| 8| 9|             

 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Dilatation                           | 3        2  2  3     4     3        2        3  1     4           3  1  1|             
      Galactocele                          |                               1  1     4  2        2     1  3  1         |             
      Hyperplasia, Focal                   |                            1           1  3                    1  1      |             

                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Dermis, Subcutaneous Tissue, Fibrosis|                   2                                                      |             

 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperostosis                         |                                              1                           |             

 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hydrocephalus                        |                                                                   2     3|             
      Hypothalamus, Degeneration           |                                     2              1     2              3|             
      Medulla, Degeneration                |                                                       3                  |             

 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Acute                  |          2                                                               |             
      Inflammation, Granulomatous          |                            1                                             |             
      Alveolar Epithelium, Hyperplasia,    |                                                                          |             
           Focal                           |                      2                                                   |             

                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Suppurative            |          2                       1  1           1           2            |             

                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Eye                                     |                                                                          |             
      Cataract                             |                                                                          |             

 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Necrosis                             |                                                                          |             
      Nephropathy                          | 1     1        1  1     1  1  1  1  1  1  1  1     1  2  1  1  1  2  2  1|             
      Renal Tubule, Pigmentation,          |                                                                          |             
          Lipofuscin                       |                                                                          |             

                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

 _____________________________________________________________________________________________________________________|             
NTP Experiment-Test: 05187-09                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           METHYLEUGENOL                                       Date: 07/20/98  
Route: GAVAGE                                                                                                     Time: 09:02:53  
                                                                                                                                    

 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 4| 6| 7| 7| 6| 4| 6| 6| 7| 7| 5| 7| 7| 4| 7| 5| 7| 7| 6| 2|            |
                             DAY ON TEST   | 3| 3| 1| 3| 0| 5| 9| 3| 3| 5| 5| 1| 4| 3| 3| 6| 3| 3| 0| 3| 9| 3| 1| 7| 4|            |
                                           | 0| 1| 9| 0| 3| 9| 8| 1| 0| 3| 9| 9| 1| 0| 1| 9| 1| 0| 7| 1| 7| 0| 1| 9| 1|      T (*) |

 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|      A     |
    0 MG/KG                                | 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2|      L     |
                                           | 1| 3| 5| 6| 7| 8| 9| 0| 1| 2| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8|            |

 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |

                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Parasite Metazoan                    |       X                                                                  |      1     |

                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Parasite Metazoan                    |    X                             X                                       |      2     |

                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |

                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |

                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |

                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |

                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Basophilic Focus                     | X  X  X  X  X  X     X  X        X     X  X     X  X  X  X  X  X  X  X  X|     36     |
      Clear Cell Focus                     |                                           X                              |      3     |
      Eosinophilic Focus                   |                   X  X                             X                 X   |     10     |
      Hepatodiaphragmatic Nodule           |                   X     X     X                                X         |      7     |
      Mixed Cell Focus                     |                                                          X        X      |      6     |
      Bile Duct, Hyperplasia               |                         1  2        2  1     2                           |     11  1.3|
      Hepatocyte, Hypertrophy              |                                                                          |      1  2.0|
      Oval Cell, Hyperplasia               |                                                                          |      1  1.0|
      Periportal, Degeneration, Fatty      |                                                                          |      1  2.0|

                                            __________________________________________________________________________|____________|
   Mesentery                               |                                              +                           |   6        |
      Artery, Inflammation, Chronic        |                                                                          |      1  4.0|
      Fat, Necrosis                        |                                              3                           |      5  2.6|

                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Acinus, Atrophy                      | 1     1           1                 1              1     1               |     10  1.5|

                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Submandibular Gland, Cytoplasmic     |                                                                          |            |
          Alteration                       |                                                                          |      1  2.0|

                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperkeratosis, Diffuse              |       3                                                                  |      1  3.0|

                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Atrophy                              |                1                                      1                  |      3  1.0|
      Ulcer                                |                            2                                             |      3  1.3|

                                            __________________________________________________________________________|____________|
   Tongue                                  |                                                                          |   1        |
      Hyperkeratosis, Focal                |                                                                          |      1  2.0|

 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Blood Vessel                            | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |

                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Degeneration, Mucoid                 |                         1                                                |      1  1.0|

 __________________________________________________________________________________________________________________________________ 

  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
NTP Experiment-Test: 05187-09                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           METHYLEUGENOL                                       Date: 07/20/98  
Route: GAVAGE                                                                                                     Time: 09:02:53  
                                                                                                                                    

 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 4| 6| 7| 7| 6| 4| 6| 6| 7| 7| 5| 7| 7| 4| 7| 5| 7| 7| 6| 2|            |
                             DAY ON TEST   | 3| 3| 1| 3| 0| 5| 9| 3| 3| 5| 5| 1| 4| 3| 3| 6| 3| 3| 0| 3| 9| 3| 1| 7| 4|            |
                                           | 0| 1| 9| 0| 3| 9| 8| 1| 0| 3| 9| 9| 1| 0| 1| 9| 1| 0| 7| 1| 7| 0| 1| 9| 1|      T (*) |

 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|      A     |
    0 MG/KG                                | 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2|      L     |
                                           | 1| 3| 5| 6| 7| 8| 9| 0| 1| 2| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8|            |

 __________________________________________________________________________________________________________________________________ 
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |            |
                                           |                                                                          |            |
      Myocardium, Degeneration             | 1  1  3  1  2  1     1     2     1     2  1  1  1        1        1  1   |     35  1.2|
      Valve, Fibrosis                      |                                                                          |      1  2.0|

 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia, Focal                   |                1  1                 1  1     1  1  1           1  1      |     13  1.1|

                                            __________________________________________________________________________|____________|
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia, Focal                   |                                                 1                        |      4  1.8|

                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia                          |                                                                          |      1  1.0|

                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  M  +  +  +  +  +|  44        |

                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Angiectasis                          |          4                                                               |      4  3.3|
      Cyst                                 |                                              3                           |      3  3.0|
      Pars Distalis, Hyperplasia, Focal    | 2        2  1  1  2        1        2           1                        |     11  1.5|
      Rathke's Cleft, Cyst                 |                      3                                                   |      1  3.0|

                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      C-Cell, Hyperplasia                  |    2     1  2        1  2  2  1  1     4  1  2  2  1  1        2         |     32  1.9|
      Follicle, Cyst                       |                                                                          |      1  1.0|

 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |

 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Clitoral Gland                          | +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Cyst                                 |                   3                                         3            |      2  3.0|
      Hyperplasia, Focal                   |                                        1                                 |      2  2.0|
      Necrosis, Focal                      |       3                                                                  |      1  3.0|

                                            __________________________________________________________________________|____________|
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cyst                                 |                                                                          |      2  3.0|

                                            __________________________________________________________________________|____________|
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia, Cystic                  |                                                                          |      2  1.5|

 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Fibrosis                             |          2                                                               |      2  2.0|
      Hyperplasia                          |                                                                          |      4  1.8|
      Myeloid Cell, Hyperplasia            |                                                                          |      1  3.0|

                                            __________________________________________________________________________|____________|
   Lymph Node                              |                               +                                +         |   2        |

 __________________________________________________________________________________________________________________________________ 

  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
NTP Experiment-Test: 05187-09                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           METHYLEUGENOL                                       Date: 07/20/98  
Route: GAVAGE                                                                                                     Time: 09:02:53  
                                                                                                                                    

 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 4| 6| 7| 7| 6| 4| 6| 6| 7| 7| 5| 7| 7| 4| 7| 5| 7| 7| 6| 2|            |
                             DAY ON TEST   | 3| 3| 1| 3| 0| 5| 9| 3| 3| 5| 5| 1| 4| 3| 3| 6| 3| 3| 0| 3| 9| 3| 1| 7| 4|            |
                                           | 0| 1| 9| 0| 3| 9| 8| 1| 0| 3| 9| 9| 1| 0| 1| 9| 1| 0| 7| 1| 7| 0| 1| 9| 1|      T (*) |

 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|      A     |
    0 MG/KG                                | 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2|      L     |
                                           | 1| 3| 5| 6| 7| 8| 9| 0| 1| 2| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8|            |

 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
      Pancreatic, Erythrophagocytosis      |                                                                1         |      1  1.0|

                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |

                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Erythrophagocytosis                  |                                                                          |      1  2.0|

                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Fibrosis                             |                            1                                             |      3  1.3|

                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |

 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Dilatation                           | 1  1        1        3  3           3           3  3  1  1  2  3  4  1   |     27  2.3|
      Galactocele                          |                   3                    2                                 |     10  2.0|
      Hyperplasia, Focal                   |             2                             2                 2            |      8  1.6|

                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Dermis, Subcutaneous Tissue, Fibrosis|                                                                          |      1  2.0|

 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperostosis                         |                                                                          |      1  1.0|

 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hydrocephalus                        |                                                             2     3      |      4  2.5|
      Hypothalamus, Degeneration           |                                  2     1           4        3     3      |      9  2.3|
      Medulla, Degeneration                |                                                                          |      1  3.0|

 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inflammation, Acute                  |                                                                          |      1  2.0|
      Inflammation, Granulomatous          |                                                                          |      1  1.0|
      Alveolar Epithelium, Hyperplasia,    |                                                                          |            |
           Focal                           | 1                                                                        |      2  1.5|

                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inflammation, Suppurative            | 1     2           1                                                      |      8  1.4|

                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |

 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Eye                                     |                                        +                                 |   1        |
      Cataract                             |                                        4                                 |      1  4.0|

 __________________________________________________________________________________________________________________________________ 

  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
NTP Experiment-Test: 05187-09                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           METHYLEUGENOL                                       Date: 07/20/98  
Route: GAVAGE                                                                                                     Time: 09:02:53  
                                                                                                                                    

 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 4| 6| 7| 7| 6| 4| 6| 6| 7| 7| 5| 7| 7| 4| 7| 5| 7| 7| 6| 2|            |
                             DAY ON TEST   | 3| 3| 1| 3| 0| 5| 9| 3| 3| 5| 5| 1| 4| 3| 3| 6| 3| 3| 0| 3| 9| 3| 1| 7| 4|            |
                                           | 0| 1| 9| 0| 3| 9| 8| 1| 0| 3| 9| 9| 1| 0| 1| 9| 1| 0| 7| 1| 7| 0| 1| 9| 1|      T (*) |

 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|      A     |
    0 MG/KG                                | 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2|      L     |
                                           | 1| 3| 5| 6| 7| 8| 9| 0| 1| 2| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8|            |

 __________________________________________________________________________________________________________________________________ 
 SPECIAL SENSES SYSTEM - cont              |                                                                          |            |
                                           |                                                                          |            |

 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Necrosis                             |                   3                                                      |      1  3.0|
      Nephropathy                          | 1  1     1  1        1  1     1        2  1     1  2     2  1  1  1      |     35  1.2|
      Renal Tubule, Pigmentation,          |                                                                          |            |
          Lipofuscin                       |                                              3                           |      1  3.0|

                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |

 __________________________________________________________________________________________________________________________________ 

  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
NTP Experiment-Test: 05187-09                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           METHYLEUGENOL                                       Date: 07/20/98  
Route: GAVAGE                                                                                                     Time: 09:02:53  
                                                                                                                                    

 _____________________________________________________________________________________________________________________              
                                           | 6| 6| 7| 5| 7| 7| 7| 7| 7| 6| 6| 7| 3| 5| 7| 4| 6| 7| 6| 6| 6| 7| 6| 7| 7|             
                             DAY ON TEST   | 8| 2| 3| 6| 0| 3| 3| 1| 1| 4| 5| 3| 4| 6| 3| 5| 9| 3| 1| 0| 6| 3| 0| 3| 3|             
                                           | 3| 0| 1| 4| 3| 0| 1| 8| 7| 6| 0| 1| 7| 9| 1| 0| 4| 1| 1| 9| 5| 0| 6| 1| 1|             

 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    37 MG/KG                               | 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             

 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Parasite Metazoan                    |                                                    X                     |             

                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Ulcer                                |                                                                          |             

                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Basophilic Focus                     | X  X  X     X  X  X  X     X  X  X  X     X  X     X  X  X     X     X  X|             
      Clear Cell Focus                     |    X                       X        X     X                          X   |             
      Eosinophilic Focus                   |       X     X  X           X     X        X     X  X                     |             
      Hepatodiaphragmatic Nodule           |                                              X                           |             
      Mixed Cell Focus                     |          X        X        X                                             |             
      Necrosis, Focal                      |       1                                                                  |             
      Bile Duct, Hyperplasia               |                   1              1                 1     2               |             
      Centrilobular, Degeneration, Fatty   |                               3                       2           4      |             
      Hepatocyte, Hypertrophy              |                                     1              1           2     2   |             
      Oval Cell, Hyperplasia               |                1  1              1  1                          1     2   |             

                                            __________________________________________________________________________|             
   Mesentery                               |       +  +        +                             +                        |             
      Fat, Necrosis                        |       2  1        2                             1                        |             

                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Acinus, Atrophy                      |                                              2                          1|             

                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Submandibular Gland, Cytoplasmic     |                                                                          |             
          Alteration                       | 2  2  2     2  2  2  2  2  2  2  2  2  2  2  2  2  2  2  2  2  2  2  2  2|             

                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +|             
      Ulcer                                |                         3                                3               |             

                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              | 2  2  1  1  1  1  1  1  3  2  1  3  1  2     2  1  2  2     2  1     1  1|             
      Ulcer                                |                      3  2     1                                          |             
      Neuroendocrine Cell, Hyperplasia     |       1                                   1                              |             

                                            __________________________________________________________________________|             
   Tongue                                  |                                                                          |             
      Hyperkeratosis, Focal                |                                                                          |             

 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Blood Vessel                            | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrium, Thrombosis                   |                                                                          |             
      Myocardium, Degeneration             | 1     1     1  2  2  1     2  2  1        1  1     1  1     1  1     1  1|             

 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

 _____________________________________________________________________________________________________________________|             
NTP Experiment-Test: 05187-09                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           METHYLEUGENOL                                       Date: 07/20/98  
Route: GAVAGE                                                                                                     Time: 09:02:53  
                                                                                                                                    

 _____________________________________________________________________________________________________________________              
                                           | 6| 6| 7| 5| 7| 7| 7| 7| 7| 6| 6| 7| 3| 5| 7| 4| 6| 7| 6| 6| 6| 7| 6| 7| 7|             
                             DAY ON TEST   | 8| 2| 3| 6| 0| 3| 3| 1| 1| 4| 5| 3| 4| 6| 3| 5| 9| 3| 1| 0| 6| 3| 0| 3| 3|             
                                           | 3| 0| 1| 4| 3| 0| 1| 8| 7| 6| 0| 1| 7| 9| 1| 0| 4| 1| 1| 9| 5| 0| 6| 1| 1|             

 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    37 MG/KG                               | 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             

 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
      Hyperplasia, Focal                   |                1     1                          2  1                     |             
      Necrosis                             |                                                                          |             

                                            __________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Focal                   |       2  1        3     1              1                 3               |             
      Infarct                              |                                                                          |             

                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  M  +  +  +  +  M  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                                                          |             
      Cyst                                 |                                        3     3                           |             
      Pars Distalis, Hyperplasia, Diffuse  |                         4                                                |             
      Pars Distalis, Hyperplasia, Focal    | 3                                               1           2     1     1|             

                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Focal, Suppurative     |                               1                                          |             
      C-Cell, Hyperplasia                  | 1  1  2        3  3  2  3        4     2  2        2     2  2  2     1   |             
      Follicular Cell, Hyperplasia, Focal  |                                           1                              |             

 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             

 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Clitoral Gland                          | +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  M  +  +  +  +  M  +  M  +|             
      Cyst                                 |                                                                          |             
      Hyperplasia, Focal                   |                                                                          |             
      Inflammation, Chronic                |                                                                          |             

                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                   3        3           3                                 |             

                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

                                            __________________________________________________________________________|             
   Vagina                                  |                                                                   +      |             
      Infiltration Cellular,               |                                                                          |             
          Polymorphonuclear                |                                                                   2      |             

 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          | 2        2  2  1                    1        2        1              2  2|             
      Inflammation, Granulomatous          |                   1                                                      |             
      Necrosis                             |                                                                          |             
      Myeloid Cell, Hyperplasia            |                               4                                   2      |             

                                            __________________________________________________________________________|             
   Lymph Node                              |                      +  +                    +                           |             
      Pancreatic, Necrosis                 |                         4                                                |             

                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrosis                             |                                  2                                       |             

 _____________________________________________________________________________________________________________________|             
NTP Experiment-Test: 05187-09                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           METHYLEUGENOL                                       Date: 07/20/98  
Route: GAVAGE                                                                                                     Time: 09:02:53  
                                                                                                                                    

 _____________________________________________________________________________________________________________________              
                                           | 6| 6| 7| 5| 7| 7| 7| 7| 7| 6| 6| 7| 3| 5| 7| 4| 6| 7| 6| 6| 6| 7| 6| 7| 7|             
                             DAY ON TEST   | 8| 2| 3| 6| 0| 3| 3| 1| 1| 4| 5| 3| 4| 6| 3| 5| 9| 3| 1| 0| 6| 3| 0| 3| 3|             
                                           | 3| 0| 1| 4| 3| 0| 1| 8| 7| 6| 0| 1| 7| 9| 1| 0| 4| 1| 1| 9| 5| 0| 6| 1| 1|             

 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    37 MG/KG                               | 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             

 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Hematopoietic Cell Proliferation     |    1        2                 4                       2           4     4|             
      Inflammation, Granulomatous          |                                                                          |             
      Necrosis                             |                                                                          |             

                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Dilatation                           |    2  1  3     2        4              2     3  2  3        2  2        2|             
      Galactocele                          |             2              3  3                          2        2  3   |             
      Hyperplasia, Cystic                  |                                  4                          4            |             
      Hyperplasia, Focal                   |                            4           2                                1|             
      Hyperplasia, Lobular                 |                                                 3                        |             

                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperostosis                         |                                                                          |             
      Osteopetrosis                        |                                                                          |             

                                            __________________________________________________________________________|             
   Skeletal Muscle                         |                                              +                           |             

 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hydrocephalus                        |             1  2                 1                 2           3         |             
      Hypothalamus, Degeneration           |                1           2  4  4                       4     1         |             

 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic                |                                                                   4      |             
      Alveolar Epithelium, Hyperplasia,    |                                                                          |             
           Focal                           |                1                                                         |             
      Interstitium, Inflammation, Chronic  |                   1                                                      |             

                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Squamous                |                                                                          |             
      Inflammation, Suppurative            |                            1                    1           1     2      |             

                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             

 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hydronephrosis                       |                                              3                           |             
      Infarct                              |                                                             2            |             
      Nephropathy                          | 1  1  1  1  1  1  2  1     2  1  1  1     1     1  1  1  1  1  1     1  1|             

 _____________________________________________________________________________________________________________________|             
NTP Experiment-Test: 05187-09                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           METHYLEUGENOL                                       Date: 07/20/98  
Route: GAVAGE                                                                                                     Time: 09:02:53  
                                                                                                                                    

 _____________________________________________________________________________________________________________________              
                                           | 6| 6| 7| 5| 7| 7| 7| 7| 7| 6| 6| 7| 3| 5| 7| 4| 6| 7| 6| 6| 6| 7| 6| 7| 7|             
                             DAY ON TEST   | 8| 2| 3| 6| 0| 3| 3| 1| 1| 4| 5| 3| 4| 6| 3| 5| 9| 3| 1| 0| 6| 3| 0| 3| 3|             
                                           | 3| 0| 1| 4| 3| 0| 1| 8| 7| 6| 0| 1| 7| 9| 1| 0| 4| 1| 1| 9| 5| 0| 6| 1| 1|             

 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    37 MG/KG                               | 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             

 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
      Renal Tubule, Accumulation, Hyaline  |                                                                          |             
          Droplet                          |                                                                          |             
      Renal Tubule, Pigmentation,          |                                                                          |             
          Lipofuscin                       |                                        3                                 |             

                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

 _____________________________________________________________________________________________________________________|             
NTP Experiment-Test: 05187-09                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           METHYLEUGENOL                                       Date: 07/20/98  
Route: GAVAGE                                                                                                     Time: 09:02:53  
                                                                                                                                    

 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 5| 7| 7| 7| 6| 7| 4| 6| 7| 7| 7| 7| 6| 7| 6| 7| 7| 7| 7| 6| 5| 7|            |
                             DAY ON TEST   | 3| 3| 3| 8| 3| 3| 3| 1| 3| 4| 8| 3| 3| 3| 3| 1| 3| 7| 3| 3| 2| 3| 3| 2| 3|            |
                                           | 0| 0| 0| 8| 1| 1| 0| 1| 0| 3| 3| 0| 0| 1| 1| 8| 0| 3| 0| 0| 4| 1| 7| 0| 0|      T (*) |

 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|      A     |
    37 MG/KG                               | 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |

 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |

                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |

                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Parasite Metazoan                    |    X                                            X              X         |      4     |

                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |

                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Ulcer                                |                                                                      3   |      1  3.0|

                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |

                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |

                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Basophilic Focus                     | X  X  X        X  X     X  X     X     X  X  X  X     X  X     X  X     X|     36     |
      Clear Cell Focus                     |                                  X     X        X     X  X               |     10     |
      Eosinophilic Focus                   | X  X  X        X  X                 X  X     X  X     X        X        X|     20     |
      Hepatodiaphragmatic Nodule           |                                                       X                  |      2     |
      Mixed Cell Focus                     | X                                                                        |      4     |
      Necrosis, Focal                      |                                                                          |      1  1.0|
      Bile Duct, Hyperplasia               | 1                 1  2  1           1                       2     1      |     11  1.3|
      Centrilobular, Degeneration, Fatty   |                                                                          |      3  3.0|
      Hepatocyte, Hypertrophy              | 3              2        3                 2  3  2     2           1     3|     13  2.1|
      Oval Cell, Hyperplasia               | 1              2  1              1  3  1  1           1        1         |     15  1.3|

                                            __________________________________________________________________________|____________|
   Mesentery                               |                                                       +                  |   5        |
      Fat, Necrosis                        |                                                       2                  |      5  1.6|

                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Acinus, Atrophy                      | 1     2     3  1  1              1           1  1                    3   |     11  1.5|

                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Submandibular Gland, Cytoplasmic     |                                                                          |            |
          Alteration                       | 2  2  2  2  2  2  2  2  2  2     2  2  2  2  2  2  2  2  2  2  2  2  2  2|     48  2.0|

                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Ulcer                                |                                                                          |      2  3.0|

                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Atrophy                              | 2  2  2           2  1  2  2  2  1     1  2  1  1  1  2  2  2  1        1|     41  1.6|
      Ulcer                                |                               2                                          |      4  2.0|
      Neuroendocrine Cell, Hyperplasia     |                1                                      1        1         |      5  1.0|

                                            __________________________________________________________________________|____________|
   Tongue                                  |                                                          +               |   1        |
      Hyperkeratosis, Focal                |                                                          2               |      1  2.0|

 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Blood Vessel                            | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |

                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |

 __________________________________________________________________________________________________________________________________ 

  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
NTP Experiment-Test: 05187-09                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           METHYLEUGENOL                                       Date: 07/20/98  
Route: GAVAGE                                                                                                     Time: 09:02:53  
                                                                                                                                    

 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 5| 7| 7| 7| 6| 7| 4| 6| 7| 7| 7| 7| 6| 7| 6| 7| 7| 7| 7| 6| 5| 7|            |
                             DAY ON TEST   | 3| 3| 3| 8| 3| 3| 3| 1| 3| 4| 8| 3| 3| 3| 3| 1| 3| 7| 3| 3| 2| 3| 3| 2| 3|            |
                                           | 0| 0| 0| 8| 1| 1| 0| 1| 0| 3| 3| 0| 0| 1| 1| 8| 0| 3| 0| 0| 4| 1| 7| 0| 0|      T (*) |

 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|      A     |
    37 MG/KG                               | 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |

 __________________________________________________________________________________________________________________________________ 
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |            |
                                           |                                                                          |            |
      Atrium, Thrombosis                   |                                                             2        2   |      2  2.0|
      Myocardium, Degeneration             | 1     1     2     1     2     2  1  1  1        1  2     1     1         |     30  1.3|

 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia, Focal                   | 1  1  1                       2        2  1     1                        |     11  1.3|
      Necrosis                             |                                                             4  3         |      2  3.5|

                                            __________________________________________________________________________|____________|
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia, Focal                   |                            1              3                          1   |      9  1.8|
      Infarct                              |                                                             4            |      1  4.0|

                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |

                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  M  +  +|  45        |

                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Angiectasis                          |                      2                             1                     |      2  1.5|
      Cyst                                 |                                                                          |      2  3.0|
      Pars Distalis, Hyperplasia, Diffuse  |                                                                          |      1  4.0|
      Pars Distalis, Hyperplasia, Focal    | 2  3  3              1  1        2              3     1  1  1  2        2|     17  1.8|

                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Inflammation, Focal, Suppurative     |                                                                          |      1  1.0|
      C-Cell, Hyperplasia                  |    1  2     4  1  1  2  2  1  2     2  2     2  1     1     3  1  2  2   |     33  1.9|
      Follicular Cell, Hyperplasia, Focal  |                                                                          |      1  1.0|

 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |

 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Clitoral Gland                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  46        |
      Cyst                                 |             3                                                            |      1  3.0|
      Hyperplasia, Focal                   | 3                                   2                    3               |      3  2.7|
      Inflammation, Chronic                | 3                                                                        |      1  3.0|

                                            __________________________________________________________________________|____________|
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cyst                                 |                      3                                3        3     3   |      7  3.0|

                                            __________________________________________________________________________|____________|
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |

                                            __________________________________________________________________________|____________|
   Vagina                                  |                                                                         +|   2        |
      Infiltration Cellular,               |                                                                          |            |
          Polymorphonuclear                |                                                                          |      1  2.0|

 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |

 __________________________________________________________________________________________________________________________________ 

  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
NTP Experiment-Test: 05187-09                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           METHYLEUGENOL                                       Date: 07/20/98  
Route: GAVAGE                                                                                                     Time: 09:02:53  
                                                                                                                                    

 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 5| 7| 7| 7| 6| 7| 4| 6| 7| 7| 7| 7| 6| 7| 6| 7| 7| 7| 7| 6| 5| 7|            |
                             DAY ON TEST   | 3| 3| 3| 8| 3| 3| 3| 1| 3| 4| 8| 3| 3| 3| 3| 1| 3| 7| 3| 3| 2| 3| 3| 2| 3|            |
                                           | 0| 0| 0| 8| 1| 1| 0| 1| 0| 3| 3| 0| 0| 1| 1| 8| 0| 3| 0| 0| 4| 1| 7| 0| 0|      T (*) |

 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|      A     |
    37 MG/KG                               | 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |

 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
      Hyperplasia                          |    1                    3           2  2     1                 2         |     15  1.7|
      Inflammation, Granulomatous          |                         1                                                |      2  1.0|
      Necrosis                             |                                                                   2      |      1  2.0|
      Myeloid Cell, Hyperplasia            |                                                                          |      2  3.0|

                                            __________________________________________________________________________|____________|
   Lymph Node                              |             +                 +                                          |   5        |
      Pancreatic, Necrosis                 |                                                                          |      1  4.0|

                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |

                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |

                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Fibrosis                             |                                              2              1            |      3  1.7|
      Hematopoietic Cell Proliferation     |                                              2                           |      7  2.7|
      Inflammation, Granulomatous          |                         2                             3                  |      2  2.5|
      Necrosis                             |             3                                                            |      1  3.0|

                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +|  48        |

 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Dilatation                           | 3     3  1     1        1        3     2        3              1     2   |     22  2.2|
      Galactocele                          |             3                       2        2                          1|     10  2.3|
      Hyperplasia, Cystic                  |                                                                          |      2  4.0|
      Hyperplasia, Focal                   |                                           1     2              2        2|      7  2.0|
      Hyperplasia, Lobular                 |                                                                          |      1  3.0|

                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |

 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperostosis                         |                                                    2                     |      1  2.0|
      Osteopetrosis                        |                                                                         3|      1  3.0|

                                            __________________________________________________________________________|____________|
   Skeletal Muscle                         |                                                                          |   1        |

 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hydrocephalus                        |             2  2                       3                          3      |      9  2.1|
      Hypothalamus, Degeneration           | 4           3  3                    4  2                          3      |     12  2.9|

 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inflammation, Chronic                |                                                                          |      1  4.0|
      Alveolar Epithelium, Hyperplasia,    |                                                                          |            |

 __________________________________________________________________________________________________________________________________ 

  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
NTP Experiment-Test: 05187-09                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           METHYLEUGENOL                                       Date: 07/20/98  
Route: GAVAGE                                                                                                     Time: 09:02:53  
                                                                                                                                    

 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 5| 7| 7| 7| 6| 7| 4| 6| 7| 7| 7| 7| 6| 7| 6| 7| 7| 7| 7| 6| 5| 7|            |
                             DAY ON TEST   | 3| 3| 3| 8| 3| 3| 3| 1| 3| 4| 8| 3| 3| 3| 3| 1| 3| 7| 3| 3| 2| 3| 3| 2| 3|            |
                                           | 0| 0| 0| 8| 1| 1| 0| 1| 0| 3| 3| 0| 0| 1| 1| 8| 0| 3| 0| 0| 4| 1| 7| 0| 0|      T (*) |

 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|      A     |
    37 MG/KG                               | 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |

 __________________________________________________________________________________________________________________________________ 
 RESPIRATORY SYSTEM - cont                 |                                                                          |            |
                                           |                                                                          |            |
           Focal                           |          2     1                                                         |      3  1.3|
      Interstitium, Inflammation, Chronic  |                                                                          |      1  1.0|

                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia, Squamous                |                                                       1                  |      1  1.0|
      Inflammation, Suppurative            |          1           3                          1              1     2  1|     10  1.4|

                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |

 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |

 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hydronephrosis                       |                                                                         2|      2  2.5|
      Infarct                              |                               1                                      2   |      3  1.7|
      Nephropathy                          | 1  1  2     2  1  2     3  2  1  1  1  1  1  1  1     1  1  1  1  1     2|     42  1.2|
      Renal Tubule, Accumulation, Hyaline  |                                                                          |            |
          Droplet                          |                            4                                             |      1  4.0|
      Renal Tubule, Pigmentation,          |                                                                          |            |
          Lipofuscin                       |                                                                          |      1  3.0|

                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |

 __________________________________________________________________________________________________________________________________ 

  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
NTP Experiment-Test: 05187-09                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           METHYLEUGENOL                                       Date: 07/20/98  
Route: GAVAGE                                                                                                     Time: 09:02:53  
                                                                                                                                    

 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 6| 7| 7| 7| 6| 7| 7| 6| 6| 7| 7| 7| 6| 6| 6| 7| 5| 7| 5| 7| 7| 7| 7|             
                             DAY ON TEST   | 3| 0| 9| 3| 3| 1| 2| 0| 3| 1| 8| 3| 3| 3| 2| 7| 2| 3| 4| 0| 1| 3| 2| 3| 1|             
                                           | 1| 9| 0| 1| 0| 7| 7| 2| 1| 3| 3| 1| 1| 0| 5| 6| 9| 1| 1| 3| 5| 0| 1| 1| 7|             

 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4|             
    75 MG/KG                               | 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             

 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +|             

                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Parasite Metazoan                    |                                              X        X                  |             

                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +|             
      Basophilic Focus                     | X        X     X        X        X  X  X        X  X  X        X     X  X|             
      Clear Cell Focus                     |                                        X           X                    X|             
      Degeneration, Cystic, Focal          |                1                                                         |             
      Eosinophilic Focus                   | X        X     X  X     X        X  X        X     X           X     X  X|             
      Hepatodiaphragmatic Nodule           |                      X                                X                  |             
      Mixed Cell Focus                     | X        X     X  X                    X        X     X        X         |             
      Necrosis, Focal                      |                         1                                                |             
      Bile Duct, Hyperplasia               | 2              2  1        2        1  1     1                       1   |             
      Centrilobular, Necrosis              |                                                                          |             
      Hepatocyte, Hypertrophy              | 3        3                             3           3                 3   |             
      Oval Cell, Hyperplasia               | 2        1              1        1  1              1           1     2  1|             

                                            __________________________________________________________________________|             
   Mesentery                               |                            +                                +            |             
      Inflammation, Chronic                |                                                             1            |             
      Fat, Necrosis                        |                            2                                             |             

                                            __________________________________________________________________________|             
   Oral Mucosa                             |                                                                          |             

                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrosis                             |       3                                                                  |             
      Acinus, Atrophy                      |                                                             1            |             

                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +|             
      Submandibular Gland, Cytoplasmic     |                                                                          |             
          Alteration                       | 2  2  2  2  2  2  2  2  2  2  2  2  2  2     2  2  2  2  2  2  2  2  2  2|             

                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |       2  2  3  2  2  1  2  2  2  2  2  3  1  1     2  2  3  2     3  2  2|             
      Mineralization                       |       2                                                                  |             
      Ulcer                                |                      2                                            2      |             
      Neuroendocrine Cell, Hyperplasia     |       1  3              3     1  1                 4                 1  2|             

 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Blood Vessel                            | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +|             
      Atrium, Thrombosis                   |                                                                          |             
      Myocardium, Degeneration             | 1        1  2     1     2     1  1  1        1     1  1     1  1  1      |             

 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             

 _____________________________________________________________________________________________________________________|             
NTP Experiment-Test: 05187-09                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           METHYLEUGENOL                                       Date: 07/20/98  
Route: GAVAGE                                                                                                     Time: 09:02:53  
                                                                                                                                    

 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 6| 7| 7| 7| 6| 7| 7| 6| 6| 7| 7| 7| 6| 6| 6| 7| 5| 7| 5| 7| 7| 7| 7|             
                             DAY ON TEST   | 3| 0| 9| 3| 3| 1| 2| 0| 3| 1| 8| 3| 3| 3| 2| 7| 2| 3| 4| 0| 1| 3| 2| 3| 1|             
                                           | 1| 9| 0| 1| 0| 7| 7| 2| 1| 3| 3| 1| 1| 0| 5| 6| 9| 1| 1| 3| 5| 0| 1| 1| 7|             

 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4|             
    75 MG/KG                               | 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             

 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Focal                   |                1                    1                                1   |             

                                            __________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Focal                   |                   2                 3                             1      |             

                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +|             
      Bilateral, Hyperplasia               |                                                             2            |             

                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                                                          |             
      Cyst                                 |                3        2                                   3            |             
      Pars Distalis, Hyperplasia, Focal    |          1                          1  1     2              2        2  3|             

                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +|             
      C-Cell, Hyperplasia                  | 2        2  2  2  2  2  2  2     1     3     4     2     3        2  2  3|             

 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             

 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Clitoral Gland                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                                                   3      |             
      Hyperplasia, Focal                   |                                        1                                 |             
      Inflammation, Suppurative            |                   3                                                      |             

                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                               3                                      3   |             

                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Endometrium, Degeneration            |                                                                          |             

 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrosis                             |             3              2                                             |             
      Hyperplasia                          | 1        1     2        2        2                             2     2  3|             
      Erythroid Cell, Hyperplasia          |                                                                          |             

                                            __________________________________________________________________________|             
   Lymph Node                              |                                                                   +      |             

                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +|             

                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +|             

                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrosis                             | 2     2                                            1                     |             
      Hematopoietic Cell Proliferation     |                3        3        2                             2         |             
      Inflammation, Focal, Suppurative     |       2                                                                  |             
      Inflammation, Granulomatous          |                                                                          |             
      Lymphoid Follicle, Hyperplasia       | 3                                                                        |             

                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  M  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                   2                                                      |             

 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             

 _____________________________________________________________________________________________________________________|             
NTP Experiment-Test: 05187-09                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           METHYLEUGENOL                                       Date: 07/20/98  
Route: GAVAGE                                                                                                     Time: 09:02:53  
                                                                                                                                    

 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 6| 7| 7| 7| 6| 7| 7| 6| 6| 7| 7| 7| 6| 6| 6| 7| 5| 7| 5| 7| 7| 7| 7|             
                             DAY ON TEST   | 3| 0| 9| 3| 3| 1| 2| 0| 3| 1| 8| 3| 3| 3| 2| 7| 2| 3| 4| 0| 1| 3| 2| 3| 1|             
                                           | 1| 9| 0| 1| 0| 7| 7| 2| 1| 3| 3| 1| 1| 0| 5| 6| 9| 1| 1| 3| 5| 0| 1| 1| 7|             

 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4|             
    75 MG/KG                               | 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             

 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Dilatation                           | 3     2           2  3  2  1     2  2  2  2  2  2  2                 2  3|             
      Galactocele                          |             2  2              3                       2                  |             
      Hyperplasia, Cystic                  |                                           4                              |             
      Hyperplasia, Focal                   |                2  2                    2     2  1                       1|             
      Inflammation, Suppurative            |                                  3                                       |             

                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Ulcer                                |                                                                          |             
      Dermis, Necrosis                     |                                           3                              |             
      Dermis, Subcutaneous Tissue, Fibrosis|                                                                         3|             
      Hair Follicle, Atrophy, Focal        |                                                                          |             

 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperostosis                         |       4                    2                                3            |             
      Osteopetrosis                        |                         3                                                |             

 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hydrocephalus                        |                                                                          |             
      Hypothalamus, Degeneration           |                                  3                    1  4               |             

 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Acute                  |       4                                                                  |             
      Inflammation, Granulomatous          |                                                                          |             
      Alveolar Epithelium, Hyperplasia,    |                                                                          |             
           Focal                           | 1                                1                                      1|             

                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Suppurative            | 1  2        1                 1  1     1              1     1           1|             

                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +|             

 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Eye                                     |                                                       +                  |             
      Cataract                             |                                                       4                  |             
      Degeneration                         |                                                                          |             

 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Infarct                              |             2                                                            |             
      Inflammation, Focal, Suppurative     |       3                                                                  |             
      Nephropathy                          | 1        1  2  1  1  1  1  1  1  2  1  2  1        1  1  1  1  1  1  1  1|             
      Renal Tubule, Pigmentation,          |                                                                          |             

 _____________________________________________________________________________________________________________________|             
NTP Experiment-Test: 05187-09                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           METHYLEUGENOL                                       Date: 07/20/98  
Route: GAVAGE                                                                                                     Time: 09:02:53  
                                                                                                                                    

 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 6| 7| 7| 7| 6| 7| 7| 6| 6| 7| 7| 7| 6| 6| 6| 7| 5| 7| 5| 7| 7| 7| 7|             
                             DAY ON TEST   | 3| 0| 9| 3| 3| 1| 2| 0| 3| 1| 8| 3| 3| 3| 2| 7| 2| 3| 4| 0| 1| 3| 2| 3| 1|             
                                           | 1| 9| 0| 1| 0| 7| 7| 2| 1| 3| 3| 1| 1| 0| 5| 6| 9| 1| 1| 3| 5| 0| 1| 1| 7|             

 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4|             
    75 MG/KG                               | 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             

 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
          Lipofuscin                       |                                                             3            |             

                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

 _____________________________________________________________________________________________________________________|             
NTP Experiment-Test: 05187-09                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           METHYLEUGENOL                                       Date: 07/20/98  
Route: GAVAGE                                                                                                     Time: 09:02:53  
                                                                                                                                    

 __________________________________________________________________________________________________________________________________ 
                                           | 6| 6| 7| 7| 6| 7| 7| 6| 5| 5| 7| 6| 4| 7| 7| 7| 7| 7| 7| 2| 7| 7| 7| 7| 5|            |
                             DAY ON TEST   | 8| 3| 3| 3| 9| 3| 3| 7| 9| 5| 3| 7| 4| 3| 3| 1| 3| 3| 3| 9| 2| 1| 3| 3| 2|            |
                                           | 3| 7| 1| 0| 0| 0| 1| 6| 5| 7| 0| 6| 4| 1| 0| 2| 0| 0| 0| 7| 4| 4| 0| 0| 7|      T (*) |

 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|      A     |
    75 MG/KG                               | 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |

 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |

                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |

                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Parasite Metazoan                    |                                                                          |      2     |

                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |

                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |

                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +|  49        |

                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |

                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Basophilic Focus                     |       X  X     X  X  X     X  X  X  X  X  X  X  X  X              X  X   |     29     |
      Clear Cell Focus                     |       X     X  X  X           X           X  X  X  X                     |     12     |
      Degeneration, Cystic, Focal          |                                                                          |      1  1.0|
      Eosinophilic Focus                   |       X  X     X  X        X  X  X  X  X  X  X  X           X     X  X   |     27     |
      Hepatodiaphragmatic Nodule           |    X  X           X        X                                             |      6     |
      Mixed Cell Focus                     |       X  X  X                    X  X  X  X     X  X              X  X   |     19     |
      Necrosis, Focal                      |                                                                          |      1  1.0|
      Bile Duct, Hyperplasia               |    2        1                       2  1  1  1     1        1        1   |     17  1.3|
      Centrilobular, Necrosis              |                                              3                           |      1  3.0|
      Hepatocyte, Hypertrophy              |    2     3  2  3  4              4  2  3        4                 3  4   |     16  3.1|
      Oval Cell, Hyperplasia               |    3        2  2  1        1     3  1        2     1                 1   |     19  1.5|

                                            __________________________________________________________________________|____________|
   Mesentery                               |                                                                   +      |   3        |
      Inflammation, Chronic                |                                                                          |      1  1.0|
      Fat, Necrosis                        |                                                                   2      |      2  2.0|

                                            __________________________________________________________________________|____________|
   Oral Mucosa                             |    +                                                                     |   1        |

                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Fibrosis                             |                                                                          |      1  3.0|
      Acinus, Atrophy                      | 1  1  1              1        1        1     1                           |      8  1.0|

                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Submandibular Gland, Cytoplasmic     |                                                                          |            |
          Alteration                       | 2  2  2  2  2  2  2  2  2  2  2  2  2  2  2  2  2  2  2  2  2  2  2  2  2|     49  2.0|

                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |

                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Atrophy                              | 2  2  2  3  3  3  4  1  1  2  2  2  1  2  1  1  3  2  3     2  2  3  3  2|     45  2.1|
      Mineralization                       |                                                                          |      1  2.0|
      Ulcer                                |                            1                                2            |      4  1.8|
      Neuroendocrine Cell, Hyperplasia     |    2                             2                                      2|     11  2.0|

 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Blood Vessel                            | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |

 __________________________________________________________________________________________________________________________________ 

  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
NTP Experiment-Test: 05187-09                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           METHYLEUGENOL                                       Date: 07/20/98  
Route: GAVAGE                                                                                                     Time: 09:02:53  
                                                                                                                                    

 __________________________________________________________________________________________________________________________________ 
                                           | 6| 6| 7| 7| 6| 7| 7| 6| 5| 5| 7| 6| 4| 7| 7| 7| 7| 7| 7| 2| 7| 7| 7| 7| 5|            |
                             DAY ON TEST   | 8| 3| 3| 3| 9| 3| 3| 7| 9| 5| 3| 7| 4| 3| 3| 1| 3| 3| 3| 9| 2| 1| 3| 3| 2|            |
                                           | 3| 7| 1| 0| 0| 0| 1| 6| 5| 7| 0| 6| 4| 1| 0| 2| 0| 0| 0| 7| 4| 4| 0| 0| 7|      T (*) |

 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|      A     |
    75 MG/KG                               | 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |

 __________________________________________________________________________________________________________________________________ 
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Atrium, Thrombosis                   |                                              4                           |      1  4.0|
      Myocardium, Degeneration             | 1           1  1  1  1  2     2        2        1     1        1     1   |     26  1.2|

 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia, Focal                   | 1  1  1                                                     1            |      7  1.0|

                                            __________________________________________________________________________|____________|
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia, Focal                   |                                                                   1      |      4  1.8|

                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |

                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  M  M  +  +  +  M  M  M  +  +  +  +  +  M  M  +  +  M  +  +  +  +  +|  41        |
      Bilateral, Hyperplasia               |                                                                          |      1  2.0|

                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Angiectasis                          |       1                 2                                                |      2  1.5|
      Cyst                                 |                                                                3         |      4  2.8|
      Pars Distalis, Hyperplasia, Focal    |             2                                1        2     2     3  1  1|     14  1.7|

                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      C-Cell, Hyperplasia                  | 3  2     1     2  2  2     4        1  3        1     1     2     2     2|     30  2.1|

 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |

 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Clitoral Gland                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Cyst                                 |                            3                                             |      2  3.0|
      Hyperplasia, Focal                   |                                                                          |      1  1.0|
      Inflammation, Suppurative            |                                                                          |      1  3.0|

                                            __________________________________________________________________________|____________|
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +|  49        |
      Cyst                                 |                                                                          |      2  3.0|

                                            __________________________________________________________________________|____________|
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +|  49        |
      Endometrium, Degeneration            |                                     3                                    |      1  3.0|

 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Fibrosis                             |                                                                          |      2  2.5|
      Hyperplasia                          |                2  2              3                                       |     11  2.0|
      Erythroid Cell, Hyperplasia          |                                     3                                    |      1  3.0|

                                            __________________________________________________________________________|____________|
   Lymph Node                              |                                                                          |   1        |

                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |

 __________________________________________________________________________________________________________________________________ 

  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
NTP Experiment-Test: 05187-09                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           METHYLEUGENOL                                       Date: 07/20/98  
Route: GAVAGE                                                                                                     Time: 09:02:53  
                                                                                                                                    

 __________________________________________________________________________________________________________________________________ 
                                           | 6| 6| 7| 7| 6| 7| 7| 6| 5| 5| 7| 6| 4| 7| 7| 7| 7| 7| 7| 2| 7| 7| 7| 7| 5|            |
                             DAY ON TEST   | 8| 3| 3| 3| 9| 3| 3| 7| 9| 5| 3| 7| 4| 3| 3| 1| 3| 3| 3| 9| 2| 1| 3| 3| 2|            |
                                           | 3| 7| 1| 0| 0| 0| 1| 6| 5| 7| 0| 6| 4| 1| 0| 2| 0| 0| 0| 7| 4| 4| 0| 0| 7|      T (*) |

 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|      A     |
    75 MG/KG                               | 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |

 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |

                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Fibrosis                             |                   1                       2                              |      5  1.6|
      Hematopoietic Cell Proliferation     |                                  3  2                                    |      6  2.5|
      Inflammation, Focal, Suppurative     |                                                                          |      1  2.0|
      Inflammation, Granulomatous          |                2                                                         |      1  2.0|
      Lymphoid Follicle, Hyperplasia       |                                                                          |      1  3.0|

                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  +  M  +  M  +  +  +  +  +  +  +  +  +  +  +|  46        |
      Atrophy                              |                                                                          |      1  2.0|

 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Dilatation                           | 3  4  2  3  2  3              1  4  2  2  1     2  2  4     3  3  1  4  3|     34  2.4|
      Galactocele                          |                   3     2  3                                             |      7  2.4|
      Hyperplasia, Cystic                  |                                                                   2      |      2  3.0|
      Hyperplasia, Focal                   |       1           3                                         1            |      9  1.7|
      Inflammation, Suppurative            |                                                                          |      1  3.0|

                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Ulcer                                |                         3                                                |      1  3.0|
      Dermis, Necrosis                     |                                                                          |      1  3.0|
      Dermis, Subcutaneous Tissue, Fibrosis|                                                                          |      1  3.0|
      Hair Follicle, Atrophy, Focal        |             3                                                            |      1  3.0|

 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperostosis                         | 1                                                                       2|      5  2.4|
      Osteopetrosis                        |                                                    2                     |      2  2.5|

 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hydrocephalus                        |                      3     4     2                                       |      3  3.0|
      Hypothalamus, Degeneration           |             1        3     2                                             |      6  2.3|

 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Inflammation, Acute                  |             1                                                            |      2  2.5|
      Inflammation, Granulomatous          |                                                             1            |      1  1.0|
      Alveolar Epithelium, Hyperplasia,    |                                                                          |            |
           Focal                           |                1  1                             1                    1   |      7  1.0|

 __________________________________________________________________________________________________________________________________ 

  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
NTP Experiment-Test: 05187-09                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           METHYLEUGENOL                                       Date: 07/20/98  
Route: GAVAGE                                                                                                     Time: 09:02:53  
                                                                                                                                    

 __________________________________________________________________________________________________________________________________ 
                                           | 6| 6| 7| 7| 6| 7| 7| 6| 5| 5| 7| 6| 4| 7| 7| 7| 7| 7| 7| 2| 7| 7| 7| 7| 5|            |
                             DAY ON TEST   | 8| 3| 3| 3| 9| 3| 3| 7| 9| 5| 3| 7| 4| 3| 3| 1| 3| 3| 3| 9| 2| 1| 3| 3| 2|            |
                                           | 3| 7| 1| 0| 0| 0| 1| 6| 5| 7| 0| 6| 4| 1| 0| 2| 0| 0| 0| 7| 4| 4| 0| 0| 7|      T (*) |

 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|      A     |
    75 MG/KG                               | 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |

 __________________________________________________________________________________________________________________________________ 
 RESPIRATORY SYSTEM - cont                 |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inflammation, Suppurative            |             2     1  1  2                          1                     |     14  1.2|

                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |

 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Eye                                     |       +                                                                  |   2        |
      Cataract                             |                                                                          |      1  4.0|
      Degeneration                         |       4                                                                  |      1  4.0|

 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Infarct                              |                                                                          |      1  2.0|
      Inflammation, Focal, Suppurative     |                                                                          |      1  3.0|
      Nephropathy                          | 1  1  1  1  1  2  2  1     1  2  1  1  1  2  1  1  1  1           1  1   |     41  1.2|
      Renal Tubule, Pigmentation,          |                                                                          |            |
          Lipofuscin                       | 3                                2                                      2|      4  2.5|

                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +|  49        |

 __________________________________________________________________________________________________________________________________ 

  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
NTP Experiment-Test: 05187-09                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           METHYLEUGENOL                                       Date: 07/20/98  
Route: GAVAGE                                                                                                     Time: 09:02:53  
                                                                                                                                    

 _____________________________________________________________________________________________________________________              
                                           | 5| 7| 7| 4| 6| 5| 6| 6| 5| 4| 7| 5| 7| 6| 6| 6| 6| 6| 5| 5| 6| 5| 6| 6| 5|             
                             DAY ON TEST   | 3| 3| 3| 8| 4| 5| 6| 0| 7| 8| 3| 0| 2| 9| 3| 0| 5| 7| 9| 4| 2| 7| 0| 1| 2|             
                                           | 4| 0| 1| 3| 1| 3| 0| 9| 6| 3| 0| 8| 4| 4| 2| 0| 2| 9| 0| 8| 0| 2| 5| 1| 7|             

 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    150                                    | 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5|             
    MG/KG                                  | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             

 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Parasite Metazoan                    |                                                                          |             
      Ulcer                                |                            3                                             |             

                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Parasite Metazoan                    |                                                          X               |             

                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoid Tissue, Hyperplasia         |                                                          2               |             

                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Basophilic Focus                     | X  X  X                    X     X              X              X  X  X   |             
      Clear Cell Focus                     | X                                X                    X           X      |             
      Degeneration, Cystic, Focal          |                   3                                1                 1   |             
      Eosinophilic Focus                   |    X  X        X  X              X  X  X     X  X  X  X     X  X  X  X   |             
      Hepatodiaphragmatic Nodule           |                                  X                                X      |             
      Mixed Cell Focus                     | X  X                                                  X              X  X|             
      Bile Duct, Hyperplasia               |    1  1        2              2  1     1     2  2  2  2        1         |             
      Centrilobular, Necrosis              |                                                                          |             
      Hepatocyte, Hypertrophy              | 1  4  4        3  2        3  4  3  3  3           3        2  2  4      |             
      Oval Cell, Hyperplasia               | 2  2  2        3  2  3     2  2  1     3        2  3  2     3  1  2  2   |             

                                            __________________________________________________________________________|             
   Mesentery                               |                                                                      +   |             
      Fat, Necrosis                        |                                                                      2   |             

                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Acinus, Atrophy                      |             1           1                                                |             

                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Submandibular Gland, Cytoplasmic     |                                                                          |             
          Alteration                       | 2  2  2     2  2  2  2  2  2  2  2  2  2  2  2  2  2  2  2  2  2  2  2  2|             

                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  A  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              | 2  3  4     2     3  2  2        1  2  3     4  2  3  3  4  3  2  3  2  3|             
      Neuroendocrine Cell, Hyperplasia     |                      3           1              3                       2|             

 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Blood Vessel                            | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Myocardium, Degeneration             |    1                    1     1  1  1        1  1  1  2                 1|             

 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Focal                   |       3                                                        1         |             
      Necrosis                             |                   1                                                      |             

                                            __________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

 _____________________________________________________________________________________________________________________|             
NTP Experiment-Test: 05187-09                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           METHYLEUGENOL                                       Date: 07/20/98  
Route: GAVAGE                                                                                                     Time: 09:02:53  
                                                                                                                                    

 _____________________________________________________________________________________________________________________              
                                           | 5| 7| 7| 4| 6| 5| 6| 6| 5| 4| 7| 5| 7| 6| 6| 6| 6| 6| 5| 5| 6| 5| 6| 6| 5|             
                             DAY ON TEST   | 3| 3| 3| 8| 4| 5| 6| 0| 7| 8| 3| 0| 2| 9| 3| 0| 5| 7| 9| 4| 2| 7| 0| 1| 2|             
                                           | 4| 0| 1| 3| 1| 3| 0| 9| 6| 3| 0| 8| 4| 4| 2| 0| 2| 9| 0| 8| 0| 2| 5| 1| 7|             

 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    150                                    | 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5|             
    MG/KG                                  | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             

 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
      Hyperplasia, Focal                   |                                                    1                     |             

                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                                                          |             

                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  M  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                   2                 3                                    |             
      Pars Distalis, Hyperplasia, Focal    |          1     2        1           2     2              1        2      |             

                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      C-Cell, Hyperplasia                  | 1  2  2     2  1  3  1        2        2  1  2     3  2  1  1        1   |             

 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             

 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Clitoral Gland                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                                                      3   |             

                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                3                                                         |             

                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cervix, Hyperplasia, Focal           | 3                                                                        |             

                                            __________________________________________________________________________|             
   Vagina                                  | +                                                                        |             

 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrosis                             |                                                    1                     |             
      Hyperplasia                          | 1  1              1           2  1  2        2  2           2            |             
      Necrosis                             |                                        4                                 |             

                                            __________________________________________________________________________|             
   Lymph Node                              |                         +           +     +              +               |             
      Pancreatic, Hyperplasia              |                                     4                                    |             
      Renal, Ectasia                       |                                     1                                    |             

                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Necrosis                             |                                        4                                 |             

                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Granulomatous          |                                                                          |             
      Necrosis                             |                                        4                                 |             

                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrosis                             |    2                                2        2                           |             
      Hematopoietic Cell Proliferation     | 3                                                           2            |             
      Inflammation, Granulomatous          |                                                                          |             
      Red Pulp, Necrosis                   |                3                       3                                 |             

                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  M  +  +  +  +  +  +  M  +  +  +  +  +  +  +  M  +  +  +  +  +  +|             

 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

 _____________________________________________________________________________________________________________________|             
NTP Experiment-Test: 05187-09                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           METHYLEUGENOL                                       Date: 07/20/98  
Route: GAVAGE                                                                                                     Time: 09:02:53  
                                                                                                                                    

 _____________________________________________________________________________________________________________________              
                                           | 5| 7| 7| 4| 6| 5| 6| 6| 5| 4| 7| 5| 7| 6| 6| 6| 6| 6| 5| 5| 6| 5| 6| 6| 5|             
                             DAY ON TEST   | 3| 3| 3| 8| 4| 5| 6| 0| 7| 8| 3| 0| 2| 9| 3| 0| 5| 7| 9| 4| 2| 7| 0| 1| 2|             
                                           | 4| 0| 1| 3| 1| 3| 0| 9| 6| 3| 0| 8| 4| 4| 2| 0| 2| 9| 0| 8| 0| 2| 5| 1| 7|             

 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    150                                    | 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5|             
    MG/KG                                  | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             

 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Dilatation                           | 4     4        2     1                 2  2     3  4           1  1  2  1|             
      Galactocele                          |                         2                                                |             
      Hyperplasia, Focal                   |                1              2                                          |             

                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hair Follicle, Atrophy, Focal        |                                                 4                        |             

 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperostosis                         |                3     3                       3     2                     |             

                                            __________________________________________________________________________|             
   Skeletal Muscle                         |                   +                                                      |             
      Degeneration, Focal                  |                   3                                                      |             

 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Congestion, Focal                    |                                        1                                 |             
      Hydrocephalus                        |                               3                       2              2   |             
      Cerebellum, Necrosis, Focal          |                                              3                           |             
      Hypothalamus, Degeneration           |                               3                             1        3   |             
      Pons, Degeneration                   |                                                                          |             

 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Alveolar Epithelium, Hyperplasia,    |                                                                          |             
           Focal                           |                                        1                                1|             

                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Suppurative            |                                                       1                  |             

                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Ear                                     |                +                                                         |             

                                            __________________________________________________________________________|             
   Lacrimal Gland                          |                                  +                                       |             

                                            __________________________________________________________________________|             
   Zymbal's Gland                          |                                                                          |             

 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Nephropathy                          | 1  2  1     1     1  1  1     2  1  2        1  1  1  1     1  1  1  1  1|             
      Renal Tubule, Pigmentation,          |                                                                          |             
          Lipofuscin                       | 3              2                                         3               |             

                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

 _____________________________________________________________________________________________________________________|             
NTP Experiment-Test: 05187-09                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           METHYLEUGENOL                                       Date: 07/20/98  
Route: GAVAGE                                                                                                     Time: 09:02:53  
                                                                                                                                    

 __________________________________________________________________________________________________________________________________ 
                                           | 6| 7| 6| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 6| 7| 6| 5| 5| 6| 7| 7| 7| 6| 6| 7|            |
                             DAY ON TEST   | 6| 1| 7| 3| 3| 2| 0| 2| 3| 3| 9| 1| 3| 4| 3| 2| 4| 8| 0| 0| 1| 3| 2| 7| 3|            |
                                           | 7| 1| 6| 1| 0| 3| 3| 4| 0| 0| 1| 1| 1| 7| 1| 0| 1| 9| 9| 2| 7| 0| 0| 9| 1|      T (*) |

 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|      A     |
    150                                    | 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8|      L     |
    MG/KG                                  | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |

 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |

                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Parasite Metazoan                    |             X                                                            |      1     |
      Ulcer                                |                                                                          |      1  3.0|

                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Parasite Metazoan                    |                                              X                           |      2     |

                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Lymphoid Tissue, Hyperplasia         |                                                                          |      1  2.0|

                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |

                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |

                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |

                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Basophilic Focus                     | X  X  X           X        X  X     X                          X         |     17     |
      Clear Cell Focus                     |                                                                          |      4     |
      Degeneration, Cystic, Focal          |       1                                                                  |      4  1.5|
      Eosinophilic Focus                   | X  X  X  X     X  X  X     X     X        X  X  X  X           X  X  X   |     31     |
      Hepatodiaphragmatic Nodule           |                                                                          |      2     |
      Mixed Cell Focus                     |       X                    X                                   X  X      |      9     |
      Bile Duct, Hyperplasia               | 2  2     1  1  1           2  1     1     1        2           2         |     22  1.5|
      Centrilobular, Necrosis              |          1                                                               |      1  1.0|
      Hepatocyte, Hypertrophy              |       3  4     3  4           3  4  4     4  4     3           4  2      |     26  3.2|
      Oval Cell, Hyperplasia               | 2  2  2  3  2  1  3     3  2  1  3  2     3  2  2  2           3  2      |     35  2.2|

                                            __________________________________________________________________________|____________|
   Mesentery                               |                      +                    +                              |   3        |
      Fat, Necrosis                        |                      2                    2                              |      3  2.0|

                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Acinus, Atrophy                      |                      1           1                             1     1   |      6  1.0|

                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Submandibular Gland, Cytoplasmic     |                                                                          |            |
          Alteration                       | 2  2  2  2  2  2  2  2  2  2  2  2  2  2  2  2  2  2  2  2  2  2  2  2  2|     49  2.0|

                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |

                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Atrophy                              | 2  3     2     2  2     3  2  2        2  2     2  2  2  1  3  2  2  3  3|     39  2.4|
      Neuroendocrine Cell, Hyperplasia     |                               2     2  2        4                 1      |      9  2.2|

 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Blood Vessel                            | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |

                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Myocardium, Degeneration             | 1              1  1     1           1     1        1           1     1  1|     20  1.1|

 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |

 __________________________________________________________________________________________________________________________________ 

  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
NTP Experiment-Test: 05187-09                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           METHYLEUGENOL                                       Date: 07/20/98  
Route: GAVAGE                                                                                                     Time: 09:02:53  
                                                                                                                                    

 __________________________________________________________________________________________________________________________________ 
                                           | 6| 7| 6| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 6| 7| 6| 5| 5| 6| 7| 7| 7| 6| 6| 7|            |
                             DAY ON TEST   | 6| 1| 7| 3| 3| 2| 0| 2| 3| 3| 9| 1| 3| 4| 3| 2| 4| 8| 0| 0| 1| 3| 2| 7| 3|            |
                                           | 7| 1| 6| 1| 0| 3| 3| 4| 0| 0| 1| 1| 1| 7| 1| 0| 1| 9| 9| 2| 7| 0| 0| 9| 1|      T (*) |

 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|      A     |
    150                                    | 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8|      L     |
    MG/KG                                  | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |

 __________________________________________________________________________________________________________________________________ 
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
                                           |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Hyperplasia, Focal                   |    1              1  1     1                          1     1           1|      9  1.2|
      Necrosis                             |                                                                          |      1  1.0|

                                            __________________________________________________________________________|____________|
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Hyperplasia, Focal                   |                         3           4                                    |      3  2.7|

                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia                          |                         1                                                |      1  1.0|

                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +     +|  46        |

                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cyst                                 |                                                                          |      2  2.5|
      Pars Distalis, Hyperplasia, Focal    |          1              2  1              1           1        2     1  1|     15  1.4|

                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      C-Cell, Hyperplasia                  |    2  2  1           1  1  2        1     2  2  1     1  2     1  1  3  1|     32  1.6|

 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |

 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Clitoral Gland                          | +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  M  M  +  +  M  +  +  +  +  +|  46        |
      Cyst                                 |                                                                          |      1  3.0|

                                            __________________________________________________________________________|____________|
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Cyst                                 |             3                                                            |      2  3.0|

                                            __________________________________________________________________________|____________|
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cervix, Hyperplasia, Focal           |                                                                          |      1  3.0|

                                            __________________________________________________________________________|____________|
   Vagina                                  |                                                       +                  |   2        |

 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Fibrosis                             |                         2                                                |      2  1.5|
      Hyperplasia                          | 1     1  2  2     1        2  1     2     2  2                          1|     20  1.6|
      Necrosis                             |                                                    2                     |      2  3.0|

                                            __________________________________________________________________________|____________|
   Lymph Node                              |                      +                 +        +        +  +        +   |  10        |
      Pancreatic, Hyperplasia              |                                                                          |      1  4.0|
      Renal, Ectasia                       |                                                                          |      1  1.0|

                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Necrosis                             |                                                                          |      1  4.0|

                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Inflammation, Granulomatous          |                                                                   3      |      1  3.0|

 __________________________________________________________________________________________________________________________________ 

  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
NTP Experiment-Test: 05187-09                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           METHYLEUGENOL                                       Date: 07/20/98  
Route: GAVAGE                                                                                                     Time: 09:02:53  
                                                                                                                                    

 __________________________________________________________________________________________________________________________________ 
                                           | 6| 7| 6| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 6| 7| 6| 5| 5| 6| 7| 7| 7| 6| 6| 7|            |
                             DAY ON TEST   | 6| 1| 7| 3| 3| 2| 0| 2| 3| 3| 9| 1| 3| 4| 3| 2| 4| 8| 0| 0| 1| 3| 2| 7| 3|            |
                                           | 7| 1| 6| 1| 0| 3| 3| 4| 0| 0| 1| 1| 1| 7| 1| 0| 1| 9| 9| 2| 7| 0| 0| 9| 1|      T (*) |

 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|      A     |
    150                                    | 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8|      L     |
    MG/KG                                  | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |

 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
      Necrosis                             |                                                                          |      1  4.0|

                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Fibrosis                             |          1     2  1     1        2  2     2           1                 2|     12  1.7|
      Hematopoietic Cell Proliferation     |                                                                          |      2  2.5|
      Inflammation, Granulomatous          |                                                                   2      |      1  2.0|
      Red Pulp, Necrosis                   |                                                                          |      2  3.0|

                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  46        |

 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Dilatation                           |          4              4  1     4  3        3     3              3      |     20  2.6|
      Galactocele                          |    3  2           2                             4     3                  |      6  2.7|
      Hyperplasia, Focal                   |                                                                          |      2  1.5|

                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hair Follicle, Atrophy, Focal        |                                                                          |      1  4.0|

 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperostosis                         |                                                                          |      4  2.8|

                                            __________________________________________________________________________|____________|
   Skeletal Muscle                         |                                                                          |   1        |
      Degeneration, Focal                  |                                                                          |      1  3.0|

 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Congestion, Focal                    |                                                                          |      1  1.0|
      Hydrocephalus                        |                   1  3                          3  1        3            |      8  2.3|
      Cerebellum, Necrosis, Focal          |                                                                          |      1  3.0|
      Hypothalamus, Degeneration           |    3                 3                          4           2            |      7  2.7|
      Pons, Degeneration                   |       4                                                                  |      1  4.0|

 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Alveolar Epithelium, Hyperplasia,    |                                                                          |            |
           Focal                           |                                                 1                        |      3  1.0|

                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inflammation, Suppurative            | 1           1                                                            |      3  1.0|

                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |

 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |

 __________________________________________________________________________________________________________________________________ 

  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
NTP Experiment-Test: 05187-09                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           METHYLEUGENOL                                       Date: 07/20/98  
Route: GAVAGE                                                                                                     Time: 09:02:53  
                                                                                                                                    

 __________________________________________________________________________________________________________________________________ 
                                           | 6| 7| 6| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 6| 7| 6| 5| 5| 6| 7| 7| 7| 6| 6| 7|            |
                             DAY ON TEST   | 6| 1| 7| 3| 3| 2| 0| 2| 3| 3| 9| 1| 3| 4| 3| 2| 4| 8| 0| 0| 1| 3| 2| 7| 3|            |
                                           | 7| 1| 6| 1| 0| 3| 3| 4| 0| 0| 1| 1| 1| 7| 1| 0| 1| 9| 9| 2| 7| 0| 0| 9| 1|      T (*) |

 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|      A     |
    150                                    | 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8|      L     |
    MG/KG                                  | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |

 __________________________________________________________________________________________________________________________________ 
 SPECIAL SENSES SYSTEM - cont              |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Ear                                     |                                                                          |   1        |

                                            __________________________________________________________________________|____________|
   Lacrimal Gland                          |                                                                          |   1        |

                                            __________________________________________________________________________|____________|
   Zymbal's Gland                          |                                           +                              |   1        |

 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Nephropathy                          | 1  1  2  1  2  1  2  1  2  2  1  2  2  1  1  1  1  1  1  2  1  2  1  1  3|     44  1.3|
      Renal Tubule, Pigmentation,          |                                                                          |            |
          Lipofuscin                       |                                                                          |      3  2.7|

                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |

 __________________________________________________________________________________________________________________________________ 

  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
NTP Experiment-Test: 05187-09                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           METHYLEUGENOL                                       Date: 07/20/98  
Route: GAVAGE                                                                                                     Time: 09:02:53  
                                                                                                                                    

 _____________________________________________________________________________________________________________________              
                                           | 5| 6| 6| 3| 7| 7| 2| 6| 4| 7| 7| 6| 6| 5| 4| 7| 6| 6| 6| 7| 6| 6| 6| 5| 7|             
                             DAY ON TEST   | 7| 6| 9| 3| 3| 3| 8| 3| 7| 3| 3| 2| 2| 1| 5| 3| 4| 1| 7| 3| 0| 5| 4| 6| 0|             
                                           | 1| 0| 4| 1| 1| 0| 1| 7| 7| 0| 0| 0| 0| 9| 9| 0| 2| 1| 9| 0| 9| 9| 1| 0| 3|             

 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
    300                                    | 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 1| 1|             
    MG/KG                                  | 2| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 1| 2| 3| 4| 6| 8| 9| 0| 1|             

 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Basophilic Focus                     |                                  X  X  X                 X  X            |             
      Clear Cell Focus                     | X        X        X                                               X      |             
      Degeneration, Cystic, Focal          | 2     2                 1  2     2  2  1              2  1  1  3  1     2|             
      Eosinophilic Focus                   | X  X     X  X     X  X  X  X  X  X  X  X  X  X  X  X  X  X  X     X     X|             
      Hepatodiaphragmatic Nodule           |                                                                          |             
      Inflammation, Granulomatous          |                                                 1                        |             
      Mixed Cell Focus                     | X              X        X     X                    X                     |             
      Necrosis, Focal                      |    2                                                                     |             
      Bile Duct, Cyst                      |                                                                          |             
      Bile Duct, Hyperplasia               | 1  2        2  1     2  2  1  1  1  2        2        2  2     1  1     4|             
      Centrilobular, Necrosis, Acute       |                                                                          |             
      Hepatocyte, Hypertrophy              | 3  4     3  4  4  3     3  4  1     4  3     4  3     3  4  2  2         |             
      Oval Cell, Hyperplasia               | 3  2     2  3  1        2  2  1  1  2  1     3  1  3  3  3  2  3  2      |             

                                            __________________________________________________________________________|             
   Mesentery                               |                                                 +                    +   |             
      Fat, Fibrosis                        |                                                 3                        |             
      Fat, Necrosis                        |                                                 2                        |             

                                            __________________________________________________________________________|             
   Oral Mucosa                             |    +                                                                     |             
      Hyperplasia, Focal                   |    1                                                                     |             

                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Focal                   |                                                                          |             
      Acinus, Atrophy                      |          1           2                                                   |             

                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Submandibular Gland, Cytoplasmic     |                                                                          |             
          Alteration                       | 2  2  2  2  2  2  2  2  2  2  2  2  2  2  2  2  2  2  2  2  2  2  2  2  2|             

                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              | 2  3  1  4        2  2  3  3  4  3  1     1           2     3  2        2|             
      Ulcer                                |                      2                                            1      |             
      Neuroendocrine Cell, Hyperplasia     |                               2                             3            |             

 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Blood Vessel                            | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Aorta, Mineralization                |                                                                4         |             

                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Myocardium, Degeneration             | 1  1  1  1     1              2  1        1  1  1              1  1     1|             

 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             

 _____________________________________________________________________________________________________________________|             
NTP Experiment-Test: 05187-09                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           METHYLEUGENOL                                       Date: 07/20/98  
Route: GAVAGE                                                                                                     Time: 09:02:53  
                                                                                                                                    

 _____________________________________________________________________________________________________________________              
                                           | 5| 6| 6| 3| 7| 7| 2| 6| 4| 7| 7| 6| 6| 5| 4| 7| 6| 6| 6| 7| 6| 6| 6| 5| 7|             
                             DAY ON TEST   | 7| 6| 9| 3| 3| 3| 8| 3| 7| 3| 3| 2| 2| 1| 5| 3| 4| 1| 7| 3| 0| 5| 4| 6| 0|             
                                           | 1| 0| 4| 1| 1| 0| 1| 7| 7| 0| 0| 0| 0| 9| 9| 0| 2| 1| 9| 0| 9| 9| 1| 0| 3|             

 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
    300                                    | 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 1| 1|             
    MG/KG                                  | 2| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 1| 2| 3| 4| 6| 8| 9| 0| 1|             

 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Focal                   |                      1        1                          1               |             
      Bilateral, Hyperplasia               |             2                                                            |             

                                            __________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Focal                   |                                  4                 4  1                  |             

                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  M|             
      Hyperplasia                          |                                                                3         |             

                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +|             
      Angiectasis                          |                                                                          |             
      Cyst                                 |    3                                                                     |             
      Pars Distalis, Hyperplasia, Focal    | 2                                   1        1           1               |             
      Pars Intermedia, Hyperplasia, Focal  |                                                       1                  |             

                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      C-Cell, Hyperplasia                  | 2              1     1  2  2  1  2  1     1  1     1  1  3  2  1  2     2|             
      Follicle, Cyst                       |                            2                                             |             

 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             

 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Clitoral Gland                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Focal                   |                                                                          |             

                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                   3        3                                             |             

                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Endometrium, Hyperplasia, Cystic     |                                                                          |             

 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrosis                             |                                     1                                    |             
      Hyperplasia                          | 2  2           2           2  2              2                 2  2      |             

                                            __________________________________________________________________________|             
   Lymph Node                              |       +              +                                   +               |             
      Renal, Inflammation, Granulomatous   |                                                          2               |             

                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrosis                             |             1              1  1  1              1     2        2  2      |             
      Hematopoietic Cell Proliferation     | 2                          2        2              2                    2|             

                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +|             

 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

 _____________________________________________________________________________________________________________________|             
NTP Experiment-Test: 05187-09                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           METHYLEUGENOL                                       Date: 07/20/98  
Route: GAVAGE                                                                                                     Time: 09:02:53  
                                                                                                                                    

 _____________________________________________________________________________________________________________________              
                                           | 5| 6| 6| 3| 7| 7| 2| 6| 4| 7| 7| 6| 6| 5| 4| 7| 6| 6| 6| 7| 6| 6| 6| 5| 7|             
                             DAY ON TEST   | 7| 6| 9| 3| 3| 3| 8| 3| 7| 3| 3| 2| 2| 1| 5| 3| 4| 1| 7| 3| 0| 5| 4| 6| 0|             
                                           | 1| 0| 4| 1| 1| 0| 1| 7| 7| 0| 0| 0| 0| 9| 9| 0| 2| 1| 9| 0| 9| 9| 1| 0| 3|             

 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
    300                                    | 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 1| 1|             
    MG/KG                                  | 2| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 1| 2| 3| 4| 6| 8| 9| 0| 1|             

 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Dilatation                           |                         2                 3  1                 2         |             
      Galactocele                          |                2           3        2                                    |             
      Hyperplasia, Focal                   |                                                                          |             

                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrous Osteodystrophy               |                                                    4           2         |             
      Hyperostosis                         |                      1                    3                              |             

                                            __________________________________________________________________________|             
   Skeletal Muscle                         |                                                                          |             
      Fibrosis                             |                                                                          |             

 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hydrocephalus                        |       2        2        3                          1              1     2|             
      Hypothalamus, Degeneration           |                         2  2                                      3      |             

 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Granulomatous          |                                                       1        1         |             
      Alveolar Epithelium, Hyperplasia,    |                                                                          |             
           Focal                           |    1                                                              1      |             
      Interstitium, Inflammation, Chronic  |                                                                          |             
      Interstitium, Mineralization         |             2                                      4                     |             

                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Suppurative            |          1                                                     1         |             

                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Zymbal's Gland                          |                                        +                                 |             

 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Nephropathy                          | 2  3  1     2  3     1  1  2  3  1  2  1     3  3  4  1  2  1  4  2  1  3|             

                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

 _____________________________________________________________________________________________________________________|             
NTP Experiment-Test: 05187-09                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           METHYLEUGENOL                                       Date: 07/20/98  
Route: GAVAGE                                                                                                     Time: 09:02:53  
                                                                                                                                    

 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 1| 6| 7| 7| 7| 7| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 6| 7| 6| 2| 7|            |
                             DAY ON TEST   | 3| 1| 8| 7| 0| 3| 2| 0| 4| 5| 3| 3| 3| 3| 0| 3| 3| 3| 2| 2| 6| 3| 0| 8| 2|            |
                                           | 1| 1| 3| 9| 3| 1| 4| 9| 1| 3| 0| 0| 1| 1| 3| 1| 0| 1| 8| 4| 5| 0| 9| 8| 4|      T (*) |

 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|      A     |
    300                                    | 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 4|      L     |
    MG/KG                                  | 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 7| 9| 0| 1| 2| 3| 4| 5| 6| 9| 0|            |

 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |

                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |

                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |

                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |

                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |

                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |

                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |

                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Basophilic Focus                     |             X  X        X  X                          X                  |     10     |
      Clear Cell Focus                     |             X           X  X                                             |      7     |
      Degeneration, Cystic, Focal          | 1        2  2  2        2  1  3  3        1  2  1     2  2  2  3  3      |     29  1.9|
      Eosinophilic Focus                   | X        X     X        X  X  X        X  X  X  X  X  X  X     X  X  X   |     37     |
      Hepatodiaphragmatic Nodule           |                            X                       X  X                  |      3     |
      Inflammation, Granulomatous          |                                                                          |      1  1.0|
      Mixed Cell Focus                     |                X                                         X               |      7     |
      Necrosis, Focal                      |                                                                          |      1  2.0|
      Bile Duct, Cyst                      |          3                                         3                     |      2  3.0|
      Bile Duct, Hyperplasia               | 2        1  1  2           1  2  2  2  2  3  2  3  2           2         |     30  1.8|
      Centrilobular, Necrosis, Acute       |                                                             3            |      1  3.0|
      Hepatocyte, Hypertrophy              | 4        2  3              2  4  4  4  4     4  4  4  2  3     4         |     31  3.3|
      Oval Cell, Hyperplasia               | 2        1  1  2  4        1  2  2  4  2     3  3  3  1        2         |     34  2.1|

                                            __________________________________________________________________________|____________|
   Mesentery                               | +                                                                        |   3        |
      Fat, Fibrosis                        |                                                                          |      1  3.0|
      Fat, Necrosis                        | 2                                                                        |      2  2.0|

                                            __________________________________________________________________________|____________|
   Oral Mucosa                             |                                                                          |   1        |
      Hyperplasia, Focal                   |                                                                          |      1  1.0|

                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia, Focal                   |                                     2                                    |      1  2.0|
      Acinus, Atrophy                      |                                  1                                1      |      4  1.3|

                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Submandibular Gland, Cytoplasmic     |                                                                          |            |
          Alteration                       | 2  2     2  2  2  2  2  2  2  2  2  2  2  2  2  2  2  2  2  2  2  2  2  2|     49  2.0|

                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |

                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Atrophy                              | 1  2     3  2  3  2  1  2  3           2  1        2  2  3  2     2     1|     33  2.2|
      Ulcer                                |                            1                                             |      3  1.3|
      Neuroendocrine Cell, Hyperplasia     |                                                       1                  |      3  2.0|

 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |

 __________________________________________________________________________________________________________________________________ 

  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
NTP Experiment-Test: 05187-09                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           METHYLEUGENOL                                       Date: 07/20/98  
Route: GAVAGE                                                                                                     Time: 09:02:53  
                                                                                                                                    

 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 1| 6| 7| 7| 7| 7| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 6| 7| 6| 2| 7|            |
                             DAY ON TEST   | 3| 1| 8| 7| 0| 3| 2| 0| 4| 5| 3| 3| 3| 3| 0| 3| 3| 3| 2| 2| 6| 3| 0| 8| 2|            |
                                           | 1| 1| 3| 9| 3| 1| 4| 9| 1| 3| 0| 0| 1| 1| 3| 1| 0| 1| 8| 4| 5| 0| 9| 8| 4|      T (*) |

 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|      A     |
    300                                    | 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 4|      L     |
    MG/KG                                  | 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 7| 9| 0| 1| 2| 3| 4| 5| 6| 9| 0|            |

 __________________________________________________________________________________________________________________________________ 
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Blood Vessel                            | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Aorta, Mineralization                |                                                                          |      1  4.0|

                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Myocardium, Degeneration             | 1  1     1  1     1     1  1     1     1     1  1           2  1        1|     27  1.1|

 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia, Focal                   |                1     1                                                   |      5  1.0|
      Bilateral, Hyperplasia               |                                                                          |      1  2.0|

                                            __________________________________________________________________________|____________|
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia, Focal                   |    4              3                       2                              |      6  3.0|

                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |

                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  M  +|  45        |
      Hyperplasia                          |                                                    2     1               |      3  2.0|

                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Angiectasis                          |          1                       1                                       |      2  1.0|
      Cyst                                 |    3                 1                                                   |      3  2.3|
      Pars Distalis, Hyperplasia, Focal    |                                        3                          1      |      6  1.5|
      Pars Intermedia, Hyperplasia, Focal  |                                                                          |      1  1.0|

                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +|  48        |
      C-Cell, Hyperplasia                  | 1  2        2     1     2  2        4     2  1  1     2  2     3  1     2|     32  1.7|
      Follicle, Cyst                       |                                                                          |      1  2.0|

 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |

 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Clitoral Gland                          | +  +  +  +  +  +  +  M  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Hyperplasia, Focal                   |                               2                                          |      1  2.0|

                                            __________________________________________________________________________|____________|
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cyst                                 |                3                    3                                    |      4  3.0|

                                            __________________________________________________________________________|____________|
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Endometrium, Hyperplasia, Cystic     |                                                       1                  |      1  1.0|

 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Fibrosis                             |    2                                      2        2                     |      4  1.8|
      Hyperplasia                          | 2        2     3     2     3  2  2  1  1     1  2  1     1  1  2  1     2|     25  1.8|

                                            __________________________________________________________________________|____________|
   Lymph Node                              |                   +  +        +                                          |   6        |

 __________________________________________________________________________________________________________________________________ 

  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
NTP Experiment-Test: 05187-09                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           METHYLEUGENOL                                       Date: 07/20/98  
Route: GAVAGE                                                                                                     Time: 09:02:53  
                                                                                                                                    

 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 1| 6| 7| 7| 7| 7| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 6| 7| 6| 2| 7|            |
                             DAY ON TEST   | 3| 1| 8| 7| 0| 3| 2| 0| 4| 5| 3| 3| 3| 3| 0| 3| 3| 3| 2| 2| 6| 3| 0| 8| 2|            |
                                           | 1| 1| 3| 9| 3| 1| 4| 9| 1| 3| 0| 0| 1| 1| 3| 1| 0| 1| 8| 4| 5| 0| 9| 8| 4|      T (*) |

 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|      A     |
    300                                    | 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 4|      L     |
    MG/KG                                  | 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 7| 9| 0| 1| 2| 3| 4| 5| 6| 9| 0|            |

 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
      Renal, Inflammation, Granulomatous   |                                                                          |      1  2.0|

                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +|  48        |

                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |

                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Fibrosis                             |                   1     1           2  2  2     2        1               |     15  1.5|
      Hematopoietic Cell Proliferation     |          3              1  2  2     2     2        2                     |     12  2.0|

                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |

 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Dilatation                           | 1           3  2           2        3                          2         |     10  2.1|
      Galactocele                          |                   3                    3                                 |      5  2.6|
      Hyperplasia, Focal                   |                         1  1                                             |      2  1.0|

                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |

 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Fibrous Osteodystrophy               |                                                          1               |      3  2.3|
      Hyperostosis                         |                                                                          |      2  2.0|

                                            __________________________________________________________________________|____________|
   Skeletal Muscle                         |          +                                                               |   1        |
      Fibrosis                             |          2                                                               |      1  2.0|

 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hydrocephalus                        |                   2                       1        2                     |      9  1.8|
      Hypothalamus, Degeneration           | 3                 3                                                      |      5  2.6|

 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inflammation, Granulomatous          |                                                                          |      2  1.0|
      Alveolar Epithelium, Hyperplasia,    |                                                                          |            |
           Focal                           |                                              1  1  1                     |      5  1.0|
      Interstitium, Inflammation, Chronic  |                                        1                                 |      1  1.0|
      Interstitium, Mineralization         |                                                                          |      2  3.0|

                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inflammation, Suppurative            |                                                             1            |      3  1.0|

                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |

 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |

 __________________________________________________________________________________________________________________________________ 

  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
NTP Experiment-Test: 05187-09                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           METHYLEUGENOL                                       Date: 07/20/98  
Route: GAVAGE                                                                                                     Time: 09:02:53  
                                                                                                                                    

 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 1| 6| 7| 7| 7| 7| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 6| 7| 6| 2| 7|            |
                             DAY ON TEST   | 3| 1| 8| 7| 0| 3| 2| 0| 4| 5| 3| 3| 3| 3| 0| 3| 3| 3| 2| 2| 6| 3| 0| 8| 2|            |
                                           | 1| 1| 3| 9| 3| 1| 4| 9| 1| 3| 0| 0| 1| 1| 3| 1| 0| 1| 8| 4| 5| 0| 9| 8| 4|      T (*) |

 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|      A     |
    300                                    | 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 4|      L     |
    MG/KG                                  | 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 7| 9| 0| 1| 2| 3| 4| 5| 6| 9| 0|            |

 __________________________________________________________________________________________________________________________________ 
 SPECIAL SENSES SYSTEM - cont              |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Zymbal's Gland                          |          +                                            +                  |   3        |

 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Nephropathy                          | 3  1     3  2  2  2  2  2  1  3  3  3  2  2  2  3  4  1  4  2  3  1     2|     45  2.2|

                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |

 __________________________________________________________________________________________________________________________________ 

  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
NTP Experiment-Test: 05187-09                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           METHYLEUGENOL                                       Date: 07/20/98  
Route: GAVAGE                                                                                                     Time: 09:02:53  
                                                                                                                                    

 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 6| 6| 7| 7| 5| 7| 7| 6| 6| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 3| 7|             
                             DAY ON TEST   | 3| 3| 1| 6| 4| 3| 2| 2| 3| 3| 6| 2| 3| 3| 2| 3| 3| 0| 3| 3| 0| 3| 1| 4| 3|             
                                           | 0| 0| 5| 1| 2| 0| 1| 1| 0| 0| 2| 6| 0| 0| 2| 0| 0| 7| 9| 0| 4| 0| 4| 4| 0|             

 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    0 MG/KG                                | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 4| 5| 6|             

 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Parasite Metazoan                    | X                                                                        |             

                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +|             
      Parasite Metazoan                    | X                                                                        |             

                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Ulcer                                |                                                                          |             

                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Ulcer                                |                                                                          |             
      Peyer's Patch, Hyperplasia           |                2                                                         |             

                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Ulcer                                |                                                                          |             

                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Basophilic Focus                     | X        X     X        X  X     X  X  X     X  X     X  X              X|             
      Clear Cell Focus                     |                                                 X                        |             
      Degeneration, Cystic, Focal          |       2  1                       1                                       |             
      Degeneration, Fatty, Focal           |                                                                          |             
      Eosinophilic Focus                   | X                          X           X  X              X               |             
      Hepatodiaphragmatic Nodule           |             X                 X                                          |             
      Inflammation, Acute                  |       1                                                                  |             
      Mixed Cell Focus                     |                            X                                             |             
      Necrosis, Focal                      |                                                                          |             
      Bile Duct, Hyperplasia               | 1                 2  3  1  1  4  2  1  1  2  2  2           2  3  2     2|             
      Centrilobular, Degeneration, Fatty   |                                  1                    2                  |             
      Centrilobular, Degeneration          |                   2           2           2                              |             
      Centrilobular, Necrosis              |       2                                                                  |             
      Oval Cell, Hyperplasia               |                      3                    1  1                           |             

                                            __________________________________________________________________________|             
   Mesentery                               |    +  +                                                                 +|             
      Fat, Necrosis                        |    2  2                                                                 2|             

                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy, Acute                       |                                                                          |             
      Hyperplasia, Focal                   |                         3           1                                    |             
      Acinus, Atrophy                      |       1           3        2           2  1  1        2  1     1  1     1|             
      Acinus, Hyperplasia, Focal           |                      1                                                   |             
      Artery, Inflammation, Chronic        |                1                    2                                    |             

                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Submandibular Gland, Cytoplasmic     |                                                                          |             
          Alteration                       |                                  2                    2              2   |             

                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperkeratosis, Focal                |                                                    2                     |             
      Mineralization                       |             1                                                            |             
      Ulcer                                |    3                                      4           3     2  3         |             

                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

 _____________________________________________________________________________________________________________________|             
NTP Experiment-Test: 05187-09                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           METHYLEUGENOL                                       Date: 07/20/98  
Route: GAVAGE                                                                                                     Time: 09:02:53  
                                                                                                                                    

 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 6| 6| 7| 7| 5| 7| 7| 6| 6| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 3| 7|             
                             DAY ON TEST   | 3| 3| 1| 6| 4| 3| 2| 2| 3| 3| 6| 2| 3| 3| 2| 3| 3| 0| 3| 3| 0| 3| 1| 4| 3|             
                                           | 0| 0| 5| 1| 2| 0| 1| 1| 0| 0| 2| 6| 0| 0| 2| 0| 0| 7| 9| 0| 4| 0| 4| 4| 0|             

 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    0 MG/KG                                | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 4| 5| 6|             

 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
                                           |                                                                          |             
      Inflammation, Focal, Suppurative     |                                                                          |             
      Mineralization                       |    2  2  4  1                 4  3                                       |             
      Ulcer                                |             3        1                                                   |             

 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Blood Vessel                            | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Mineralization                       |                               2                                          |             
      Aorta, Mineralization                |       2  4                       2                                       |             

                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrium, Thrombosis                   |                                                                   2      |             
      Myocardium, Degeneration             | 1  2     2  1  1  1  2  1  2  2  3  2  2  2  2  2     1  2  1  3  1     2|             
      Myocardium, Mineralization           |       2                       1  1                                       |             

 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Focal                   |             1  1           1           1        1        1  1  1        1|             
      Necrosis                             |                                                                          |             

                                            __________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Focal                   |    3     4  1     2        1     3  3                    3  2           1|             

                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Focal                   |                                     2                                    |             
      Hyperplasia                          |                3           2     4              2                        |             
      Bilateral, Hyperplasia               |    4  3  4  3                 4           2                 2            |             

                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                           2                              |             
      Pars Distalis, Hyperplasia, Focal    | 1  2  2        1           2           1     1  3                 2      |             

                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      C-Cell, Hyperplasia                  | 2  2        1  1        1  1        1  3        1              1         |             
      Follicle, Cyst                       |                                  2                                       |             

 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Peritoneum                              |                                                                          |             

 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

                                            __________________________________________________________________________|             
   Preputial Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                                                          |             
      Hyperplasia, Focal                   |             1                                   2                        |             
      Inflammation, Chronic                |                      2           1           1                           |             

                                            __________________________________________________________________________|             
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic                |             1  2  1  2     1  1                                1         |             

                                            __________________________________________________________________________|             
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

                                            __________________________________________________________________________|             
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

 _____________________________________________________________________________________________________________________|             
NTP Experiment-Test: 05187-09                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           METHYLEUGENOL                                       Date: 07/20/98  
Route: GAVAGE                                                                                                     Time: 09:02:53  
                                                                                                                                    

 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 6| 6| 7| 7| 5| 7| 7| 6| 6| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 3| 7|             
                             DAY ON TEST   | 3| 3| 1| 6| 4| 3| 2| 2| 3| 3| 6| 2| 3| 3| 2| 3| 3| 0| 3| 3| 0| 3| 1| 4| 3|             
                                           | 0| 0| 5| 1| 2| 0| 1| 1| 0| 0| 2| 6| 0| 0| 2| 0| 0| 7| 9| 0| 4| 0| 4| 4| 0|             

 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    0 MG/KG                                | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 4| 5| 6|             

 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
      Germinal Epithelium, Atrophy         |             4        3              2                                    |             
      Interstitial Cell, Hyperplasia       |             3        3                                                   |             

 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrosis                             |                      3                                                   |             
      Hyperplasia                          |       1        1        1     1  1        1  1        2  1               |             

                                            __________________________________________________________________________|             
   Lymph Node                              |                                           +           +     +            |             
      Mediastinal, Hyperplasia, Lymphoid   |                                           2           2                  |             

                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Ectasia                              |                                                                          |             

                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrosis                             |                2        1                 1  1           2        1      |             
      Hematopoietic Cell Proliferation     |                                                                          |             
      Metaplasia, Lipocyte                 |                         1                                                |             
      Lymphoid Follicle, Depletion Cellular|                                                                          |             

                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                                                          |             

 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Dilatation                           |                      2     1                                   2         |             
      Galactocele                          |             3                                                            |             
      Duct, Granuloma                      |                                                                          |             

                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst Epithelial Inclusion            |                                                                          |             
      Ulcer                                |                                                                          |             
      Subcutaneous Tissue, Fibrosis        |                                                 3                        |             

 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrous Osteodystrophy               |    3  2  3  1                 2  3                                       |             
      Osteopetrosis                        |                      2                                                   |             

 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Degeneration, Focal                  |                                                                          |             
      Hydrocephalus                        |                                                                          |             
      Necrosis                             |                      2                                                   |             

                                            __________________________________________________________________________|             
   Peripheral Nerve                        |                                                                          |             

                                            __________________________________________________________________________|             
   Spinal Cord                             |                                                                          |             
      Axon, Degeneration, Focal            |                                                                          |             

 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             

 _____________________________________________________________________________________________________________________|             
NTP Experiment-Test: 05187-09                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           METHYLEUGENOL                                       Date: 07/20/98  
Route: GAVAGE                                                                                                     Time: 09:02:53  
                                                                                                                                    

 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 6| 6| 7| 7| 5| 7| 7| 6| 6| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 3| 7|             
                             DAY ON TEST   | 3| 3| 1| 6| 4| 3| 2| 2| 3| 3| 6| 2| 3| 3| 2| 3| 3| 0| 3| 3| 0| 3| 1| 4| 3|             
                                           | 0| 0| 5| 1| 2| 0| 1| 1| 0| 0| 2| 6| 0| 0| 2| 0| 0| 7| 9| 0| 4| 0| 4| 4| 0|             

 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    0 MG/KG                                | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 4| 5| 6|             

 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Infiltration Cellular, Histiocyte    |       3                                                                  |             
      Inflammation, Granulomatous          |                                                                          |             
      Inflammation, Suppurative            |                                                       3                  |             
      Interstitium, Inflammation, Chronic  |                                                                          |             
      Interstitium, Mineralization         |          3                       2                                       |             
      Vein, Thrombosis                     |                                                                          |             

                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Suppurative            |       1                 2        2                 1  1           2     1|             

                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Eye                                     |                                                                          |             
      Cataract                             |                                                                          |             

                                            __________________________________________________________________________|             
   Zymbal's Gland                          |                                                                          |             

 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Nephropathy                          | 2  4  4  4  4  3  1  2  3  4  3  4  3  3  4  2  3  1  2  2  3  2  2     3|             
      Renal Tubule, Hyperplasia, Focal     |          4  1                       2                       2            |             

                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Ulcer                                |                                                                          |             
      Transitional Epithelium, Hyperplasia |                                                                          |             

 _____________________________________________________________________________________________________________________|             
NTP Experiment-Test: 05187-09                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           METHYLEUGENOL                                       Date: 07/20/98  
Route: GAVAGE                                                                                                     Time: 09:02:53  
                                                                                                                                    

 __________________________________________________________________________________________________________________________________ 
                                           | 7| 6| 7| 5| 7| 6| 7| 6| 6| 7| 7| 5| 7| 6| 6| 5| 7| 7| 7| 7| 6| 5| 7| 7| 7|            |
                             DAY ON TEST   | 0| 1| 3| 6| 3| 1| 3| 1| 0| 3| 3| 5| 3| 1| 5| 8| 0| 2| 2| 3| 6| 2| 1| 3| 1|            |
                                           | 4| 0| 0| 4| 0| 7| 0| 0| 3| 0| 0| 3| 0| 4| 2| 8| 7| 2| 9| 0| 8| 9| 8| 0| 2|      T (*) |

 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      A     |
    0 MG/KG                                | 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 6|      L     |
                                           | 7| 8| 9| 1| 2| 4| 6| 9| 0| 1| 2| 3| 4| 6| 7| 8| 9| 0| 1| 3| 4| 5| 7| 9| 0|            |

 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |

                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Parasite Metazoan                    |                                                                          |      1     |

                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Parasite Metazoan                    |                                                                          |      1     |

                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Ulcer                                |                                                             2            |      1  2.0|

                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Ulcer                                |       1                                            4  1                  |      3  2.0|
      Peyer's Patch, Hyperplasia           |                                                                          |      1  2.0|

                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |

                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Ulcer                                |                      2                                                   |      1  2.0|

                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Basophilic Focus                     | X  X     X  X              X  X           X     X                    X  X|     23     |
      Clear Cell Focus                     |    X                                            X                 X      |      4     |
      Degeneration, Cystic, Focal          |                                                                   1      |      4  1.3|
      Degeneration, Fatty, Focal           |                                              1                           |      1  1.0|
      Eosinophilic Focus                   | X     X                       X                 X                 X  X   |     11     |
      Hepatodiaphragmatic Nodule           |                X                       X                                 |      4     |
      Inflammation, Acute                  |                                                                          |      1  1.0|
      Mixed Cell Focus                     |                                                                          |      1     |
      Necrosis, Focal                      |                            1        1                                    |      2  1.0|
      Bile Duct, Hyperplasia               | 1  2     1  1  4  3  3     1  1     2  4     2  3     1  1  2  2  2  3  2|     36  2.0|
      Centrilobular, Degeneration, Fatty   |                                                                          |      2  1.5|
      Centrilobular, Degeneration          |                                  2  2                       3            |      6  2.2|
      Centrilobular, Necrosis              |                                                                          |      1  2.0|
      Oval Cell, Hyperplasia               |    1           4  2  3        1     3  3        1     1        2     2   |     14  2.0|

                                            __________________________________________________________________________|____________|
   Mesentery                               |                                  +                          +            |   5        |
      Fat, Necrosis                        |                                  4                          2            |      5  2.4|

                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Atrophy, Acute                       |                                                             2            |      1  2.0|
      Hyperplasia, Focal                   |                                           1                              |      3  1.7|
      Acinus, Atrophy                      |             1  1     1        1  1           1  1     1              2   |     20  1.3|
      Acinus, Hyperplasia, Focal           |                                                                          |      1  1.0|
      Artery, Inflammation, Chronic        |                            4  2                                          |      4  2.3|

                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Submandibular Gland, Cytoplasmic     |                                                                          |            |
          Alteration                       |                                           3                              |      4  2.3|

 __________________________________________________________________________________________________________________________________ 

  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
NTP Experiment-Test: 05187-09                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           METHYLEUGENOL                                       Date: 07/20/98  
Route: GAVAGE                                                                                                     Time: 09:02:53  
                                                                                                                                    

 __________________________________________________________________________________________________________________________________ 
                                           | 7| 6| 7| 5| 7| 6| 7| 6| 6| 7| 7| 5| 7| 6| 6| 5| 7| 7| 7| 7| 6| 5| 7| 7| 7|            |
                             DAY ON TEST   | 0| 1| 3| 6| 3| 1| 3| 1| 0| 3| 3| 5| 3| 1| 5| 8| 0| 2| 2| 3| 6| 2| 1| 3| 1|            |
                                           | 4| 0| 0| 4| 0| 7| 0| 0| 3| 0| 0| 3| 0| 4| 2| 8| 7| 2| 9| 0| 8| 9| 8| 0| 2|      T (*) |

 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      A     |
    0 MG/KG                                | 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 6|      L     |
                                           | 7| 8| 9| 1| 2| 4| 6| 9| 0| 1| 2| 3| 4| 6| 7| 8| 9| 0| 1| 3| 4| 5| 7| 9| 0|            |

 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperkeratosis, Focal                |                                                                          |      1  2.0|
      Mineralization                       |                                              3                    2      |      3  2.0|
      Ulcer                                | 2           3                                                            |      7  2.9|

                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inflammation, Focal, Suppurative     |                                              2              2            |      2  2.0|
      Mineralization                       |                                              2  3        2        4      |     10  2.7|
      Ulcer                                |                2                       1                                 |      4  1.8|

 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Blood Vessel                            | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Mineralization                       |                                                                          |      1  2.0|
      Aorta, Mineralization                |                                                 3                 4      |      5  3.0|

                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Atrium, Thrombosis                   |                      2           4  4                 4     3            |      6  3.2|
      Myocardium, Degeneration             | 1  2     1  2  2  2     1  1  2  2  1  1  2  3  3  3  2  1  2  1  2  2  2|     45  1.8|
      Myocardium, Mineralization           |                                                 2                 3      |      5  1.8|

 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia, Focal                   |    1           1           1  1                                          |     13  1.0|
      Necrosis                             |                                              1                           |      1  1.0|

                                            __________________________________________________________________________|____________|
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia, Focal                   |    3  4              1           1     1                                3|     16  2.3|

                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |

                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  M  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Hyperplasia, Focal                   |                                                             1            |      2  1.5|
      Hyperplasia                          |             4     2           2                                          |      7  2.7|
      Bilateral, Hyperplasia               |                                                 3                 3     2|     10  3.0|

                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Angiectasis                          |                                                                1         |      2  1.5|
      Pars Distalis, Hyperplasia, Focal    |                   1                                            2     2   |     12  1.7|

                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      C-Cell, Hyperplasia                  | 1  1  2     1  1  1           1        2           2  1     3        2   |     22  1.5|
      Follicle, Cyst                       |                                                                          |      1  2.0|

 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Peritoneum                              |          +                                                               |   1        |

 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |

 __________________________________________________________________________________________________________________________________ 

  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
NTP Experiment-Test: 05187-09                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           METHYLEUGENOL                                       Date: 07/20/98  
Route: GAVAGE                                                                                                     Time: 09:02:53  
                                                                                                                                    

 __________________________________________________________________________________________________________________________________ 
                                           | 7| 6| 7| 5| 7| 6| 7| 6| 6| 7| 7| 5| 7| 6| 6| 5| 7| 7| 7| 7| 6| 5| 7| 7| 7|            |
                             DAY ON TEST   | 0| 1| 3| 6| 3| 1| 3| 1| 0| 3| 3| 5| 3| 1| 5| 8| 0| 2| 2| 3| 6| 2| 1| 3| 1|            |
                                           | 4| 0| 0| 4| 0| 7| 0| 0| 3| 0| 0| 3| 0| 4| 2| 8| 7| 2| 9| 0| 8| 9| 8| 0| 2|      T (*) |

 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      A     |
    0 MG/KG                                | 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 6|      L     |
                                           | 7| 8| 9| 1| 2| 4| 6| 9| 0| 1| 2| 3| 4| 6| 7| 8| 9| 0| 1| 3| 4| 5| 7| 9| 0|            |

 __________________________________________________________________________________________________________________________________ 
 GENITAL SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |

                                            __________________________________________________________________________|____________|
   Preputial Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cyst                                 |       3                    3                    3           2        3   |      5  2.8|
      Hyperplasia, Focal                   |                               3                                          |      3  2.0|
      Inflammation, Chronic                |          4                             1     2              2  1     2   |      9  1.8|

                                            __________________________________________________________________________|____________|
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inflammation, Chronic                |    1  1  1                             1  2     1  2        1  1         |     16  1.3|

                                            __________________________________________________________________________|____________|
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |

                                            __________________________________________________________________________|____________|
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Germinal Epithelium, Atrophy         |                                                                          |      3  3.0|
      Interstitial Cell, Hyperplasia       |                                           2                              |      3  2.7|

 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Fibrosis                             |                               2                       2                  |      3  2.3|
      Hyperplasia                          | 1  2     2        1        1  1     1                    2           1   |     18  1.2|

                                            __________________________________________________________________________|____________|
   Lymph Node                              |                         +        +  +        +     +                     |   8        |
      Mediastinal, Hyperplasia, Lymphoid   |                                                                          |      2  2.0|

                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |

                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Ectasia                              |                            3                                             |      1  3.0|

                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Fibrosis                             |                                                       2           2      |      8  1.5|
      Hematopoietic Cell Proliferation     |                                     4                 4                  |      2  4.0|
      Metaplasia, Lipocyte                 |                                                                          |      1  1.0|
      Lymphoid Follicle, Depletion Cellular|                                                                   4      |      1  4.0|

                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  M  +  M  +  +  +  +|  46        |
      Cyst                                 |                                     3                                    |      1  3.0|

 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Dilatation                           |       2        1  1                    1  2  4  1  1  1     2            |     13  1.6|
      Galactocele                          |                                                                          |      1  3.0|
      Duct, Granuloma                      |                                           4                              |      1  4.0|

                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cyst Epithelial Inclusion            |          3                                                               |      1  3.0|
      Ulcer                                |          3           3                                                   |      2  3.0|
      Subcutaneous Tissue, Fibrosis        |                                                                          |      1  3.0|

 __________________________________________________________________________________________________________________________________ 

  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
NTP Experiment-Test: 05187-09                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           METHYLEUGENOL                                       Date: 07/20/98  
Route: GAVAGE                                                                                                     Time: 09:02:53  
                                                                                                                                    

 __________________________________________________________________________________________________________________________________ 
                                           | 7| 6| 7| 5| 7| 6| 7| 6| 6| 7| 7| 5| 7| 6| 6| 5| 7| 7| 7| 7| 6| 5| 7| 7| 7|            |
                             DAY ON TEST   | 0| 1| 3| 6| 3| 1| 3| 1| 0| 3| 3| 5| 3| 1| 5| 8| 0| 2| 2| 3| 6| 2| 1| 3| 1|            |
                                           | 4| 0| 0| 4| 0| 7| 0| 0| 3| 0| 0| 3| 0| 4| 2| 8| 7| 2| 9| 0| 8| 9| 8| 0| 2|      T (*) |

 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      A     |
    0 MG/KG                                | 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 6|      L     |
                                           | 7| 8| 9| 1| 2| 4| 6| 9| 0| 1| 2| 3| 4| 6| 7| 8| 9| 0| 1| 3| 4| 5| 7| 9| 0|            |

 __________________________________________________________________________________________________________________________________ 
 INTEGUMENTARY SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |

 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Fibrous Osteodystrophy               |                                                 2                 3      |      8  2.4|
      Osteopetrosis                        |                                                                          |      1  2.0|

 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Degeneration, Focal                  |                                                    2                     |      1  2.0|
      Hydrocephalus                        |       2                                                     2            |      2  2.0|
      Necrosis                             |                                                                          |      1  2.0|

                                            __________________________________________________________________________|____________|
   Peripheral Nerve                        |                +                                                         |   1        |

                                            __________________________________________________________________________|____________|
   Spinal Cord                             |                +                                                         |   1        |
      Axon, Degeneration, Focal            |                1                                                         |      1  1.0|

 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Infiltration Cellular, Histiocyte    |                                                                          |      1  3.0|
      Inflammation, Granulomatous          |                                                    1        1            |      2  1.0|
      Inflammation, Suppurative            |                                                                          |      1  3.0|
      Interstitium, Inflammation, Chronic  | 1                                         1                              |      2  1.0|
      Interstitium, Mineralization         |                                                 3                 2      |      4  2.5|
      Vein, Thrombosis                     |                                                       4                  |      1  4.0|

                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inflammation, Suppurative            |                      1  1                             2           2      |     11  1.5|

                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |

 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Eye                                     |                                  +                                       |   1        |
      Cataract                             |                                  4                                       |      1  4.0|

                                            __________________________________________________________________________|____________|
   Zymbal's Gland                          |                                                                         +|   1        |

 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Nephropathy                          | 2  1  3  2  4  3  3  3  3  3  3  3  2  3  1  3  4  3  4  3  2  2  4  2  3|     49  2.8|
      Renal Tubule, Hyperplasia, Focal     |             2                                                            |      5  2.2|

                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Ulcer                                |                3                                                         |      1  3.0|
      Transitional Epithelium, Hyperplasia |                                        1                                 |      1  1.0|

 __________________________________________________________________________________________________________________________________ 

  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
NTP Experiment-Test: 05187-09                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           METHYLEUGENOL                                       Date: 07/20/98  
Route: GAVAGE                                                                                                     Time: 09:02:53  
                                                                                                                                    

 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 7| 7| 7| 5| 7| 6| 7| 5| 7| 5| 7| 7| 6| 5| 6| 6| 7| 7| 5| 6| 4| 6| 6|             
                             DAY ON TEST   | 0| 7| 3| 3| 0| 7| 3| 0| 3| 8| 1| 9| 3| 3| 2| 7| 0| 5| 3| 3| 7| 8| 3| 3| 7|             
                                           | 4| 3| 0| 0| 4| 9| 0| 2| 0| 9| 8| 1| 0| 0| 5| 9| 6| 0| 0| 0| 2| 0| 1| 8| 4|             

 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    37 MG/KG                               | 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             

 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Parasite Metazoan                    |                                                                X     X   |             

                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Parasite Metazoan                    |                                                                          |             

                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Ulcer                                |                                                                1         |             

                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic, Focal         |                                                             2            |             

                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Basophilic Focus                     |          X     X        X  X     X           X           X  X           X|             
      Clear Cell Focus                     |                X           X     X                                       |             
      Degeneration, Cystic, Focal          |                                                    1                     |             
      Eosinophilic Focus                   |       X  X     X        X  X  X     X  X  X  X     X  X  X        X  X  X|             
      Hepatodiaphragmatic Nodule           |          X                                                               |             
      Mixed Cell Focus                     |          X     X           X     X  X                                    |             
      Necrosis, Focal                      |                                                    1                     |             
      Bile Duct, Hyperplasia               |    2     1        1        1  1  1  1     1     1              3         |             
      Centrilobular, Degeneration          |                                                                          |             
      Centrilobular, Necrosis              |             3                                   2              2         |             
      Hepatocyte, Hypertrophy              |          2     2                    2        3           1  1     3     1|             
      Oval Cell, Hyperplasia               | 4        1     1           1     1        1  2              1     1     2|             

                                            __________________________________________________________________________|             
   Mesentery                               |                         +           +                                    |             
      Fat, Necrosis                        |                         2           2                                    |             

                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Focal                   |                                                                          |             
      Acinus, Atrophy                      |    1  1  1     1  1           2           2                    1         |             
      Acinus, Hyperplasia, Focal           |                                                                          |             

                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Submandibular Gland, Cytoplasmic     |                                                                          |             
          Alteration                       | 2  2  2  2  2  2  2  2  2  2  2  2  2  2  2  2  2  2  2  2  2  2  2  2  2|             

                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Ulcer                                |                                                                          |             

                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |       2  3        1     1                 1                       1  3   |             
      Inflammation, Focal, Suppurative     |                                                 2  1                     |             
      Mineralization                       |             1                                                        1   |             
      Ulcer                                | 3                                                                        |             

                                            __________________________________________________________________________|             
   Tongue                                  |                                                                          |             

 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Blood Vessel                            | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

 _____________________________________________________________________________________________________________________|             
NTP Experiment-Test: 05187-09                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           METHYLEUGENOL                                       Date: 07/20/98  
Route: GAVAGE                                                                                                     Time: 09:02:53  
                                                                                                                                    

 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 7| 7| 7| 5| 7| 6| 7| 5| 7| 5| 7| 7| 6| 5| 6| 6| 7| 7| 5| 6| 4| 6| 6|             
                             DAY ON TEST   | 0| 7| 3| 3| 0| 7| 3| 0| 3| 8| 1| 9| 3| 3| 2| 7| 0| 5| 3| 3| 7| 8| 3| 3| 7|             
                                           | 4| 3| 0| 0| 4| 9| 0| 2| 0| 9| 8| 1| 0| 0| 5| 9| 6| 0| 0| 0| 2| 0| 1| 8| 4|             

 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    37 MG/KG                               | 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             

 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |             
                                           |                                                                          |             
      Mineralization                       |                                                 2                        |             

                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Focal, Suppurative     |                                                    2                     |             
      Atrium, Thrombosis                   |             3                                                  2         |             
      Endocardium, Fibrosis                |                                                       2                  |             
      Myocardium, Degeneration             |          2     1  1     1     1  2  1  1  1  1  3  2     2  2  1  2  1  2|             
      Myocardium, Mineralization           |                                                                          |             
      Valve, Thrombosis                    |                                                    2                     |             

 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Focal                   |       1           1     1     1                    3                    1|             
      Necrosis                             |                                                    3                     |             

                                            __________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Focal                   | 3  1  2        2              2  2     4     2  2     1  2  1            |             
      Hyperplasia                          |             4                                                            |             

                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |          1                 2                                             |             

                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |             1                                                  1         |             
      Bilateral, Hyperplasia               |       1                                                                 1|             

                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Pars Distalis, Hyperplasia, Focal    |             2                          2              1  1               |             

                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      C-Cell, Hyperplasia                  | 1     1  2  1  1  2                 1  2     3        1     1  1  1  3   |             
      Follicle, Cyst                       |                                                                          |             

 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Peritoneum                              |                                                                          |             

 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

                                            __________________________________________________________________________|             
   Preputial Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                                                          |             
      Hyperplasia, Focal                   |    3                                      1        2                 4   |             
      Inflammation, Chronic                |                      2     1     1        1        2        2           1|             
      Inflammation, Chronic Active         |    3                                                                     |             

                                            __________________________________________________________________________|             
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Focal                   |                                                                          |             
      Inflammation, Chronic                | 1                    1     2     1  1  1           1        1     2      |             

                                            __________________________________________________________________________|             
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Suppurative            |                   2                                                      |             

                                            __________________________________________________________________________|             
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Germinal Epithelium, Atrophy         |                                                                          |             

 _____________________________________________________________________________________________________________________|             
NTP Experiment-Test: 05187-09                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           METHYLEUGENOL                                       Date: 07/20/98  
Route: GAVAGE                                                                                                     Time: 09:02:53  
                                                                                                                                    

 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 7| 7| 7| 5| 7| 6| 7| 5| 7| 5| 7| 7| 6| 5| 6| 6| 7| 7| 5| 6| 4| 6| 6|             
                             DAY ON TEST   | 0| 7| 3| 3| 0| 7| 3| 0| 3| 8| 1| 9| 3| 3| 2| 7| 0| 5| 3| 3| 7| 8| 3| 3| 7|             
                                           | 4| 3| 0| 0| 4| 9| 0| 2| 0| 9| 8| 1| 0| 0| 5| 9| 6| 0| 0| 0| 2| 0| 1| 8| 4|             

 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    37 MG/KG                               | 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             

 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             

 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                2        2           1        2        1  1              1|             
      Necrosis                             |                                                                1         |             

                                            __________________________________________________________________________|             
   Lymph Node                              | +                                                                        |             

                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Congestion                           |                                                                          |             
      Fibrosis                             |             2           2              2                                 |             
      Hematopoietic Cell Proliferation     |             2  3                             1                 4         |             

                                            __________________________________________________________________________|             
   Thymus                                  | +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Dilatation                           | 2        1           2     1        1     1                 1            |             
      Hyperplasia, Focal                   |                                                                          |             

                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Dermis, Inflammation, Focal,         |                                                                          |             
          Suppurative                      |                                                       3                  |             

 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrous Osteodystrophy               |                                                                          |             
      Osteopetrosis                        |    3              3                                                      |             

                                            __________________________________________________________________________|             
   Skeletal Muscle                         |                                                                          |             

 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hydrocephalus                        |                            3                                3            |             
      Necrosis, Focal                      |    1                                               2                     |             
      Hypothalamus, Degeneration           |                                                                          |             

                                            __________________________________________________________________________|             
   Peripheral Nerve                        |                                                                          |             

                                            __________________________________________________________________________|             
   Spinal Cord                             |                                                                          |             

 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Erythrophagocytosis                  |                                                 3                        |             
      Inflammation, Suppurative            |    3                                                                     |             
      Alveolar Epithelium, Hyperplasia,    |                                                                          |             
           Focal                           |                                                                          |             
      Interstitium, Inflammation, Chronic  |                                                                          |             
      Interstitium, Mineralization         |                                                                          |             

 _____________________________________________________________________________________________________________________|             
NTP Experiment-Test: 05187-09                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           METHYLEUGENOL                                       Date: 07/20/98  
Route: GAVAGE                                                                                                     Time: 09:02:53  
                                                                                                                                    

 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 7| 7| 7| 5| 7| 6| 7| 5| 7| 5| 7| 7| 6| 5| 6| 6| 7| 7| 5| 6| 4| 6| 6|             
                             DAY ON TEST   | 0| 7| 3| 3| 0| 7| 3| 0| 3| 8| 1| 9| 3| 3| 2| 7| 0| 5| 3| 3| 7| 8| 3| 3| 7|             
                                           | 4| 3| 0| 0| 4| 9| 0| 2| 0| 9| 8| 1| 0| 0| 5| 9| 6| 0| 0| 0| 2| 0| 1| 8| 4|             

 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    37 MG/KG                               | 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             

 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
      Perivascular, Edema                  |                                  3                                       |             

                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Suppurative            |                   1  2                             1              1      |             

                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Eye                                     |                                                                   +      |             
      Cornea, Inflammation, Chronic        |                                                                   1      |             

                                            __________________________________________________________________________|             
   Zymbal's Gland                          |                +                                                         |             

 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Focal, Suppurative     |                                                    2                     |             
      Nephropathy                          | 3  3  3  3  4  2  2  2  3  3  3  2  2  3  2  1  1     2  3  2  3  1  2  3|             
      Renal Tubule, Cyst                   |                                                          3               |             
      Renal Tubule, Hyperplasia, Focal     |                                                                          |             

                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Ulcer                                |                                                                          |             

 _____________________________________________________________________________________________________________________|             
NTP Experiment-Test: 05187-09                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           METHYLEUGENOL                                       Date: 07/20/98  
Route: GAVAGE                                                                                                     Time: 09:02:53  
                                                                                                                                    

 __________________________________________________________________________________________________________________________________ 
                                           | 7| 5| 5| 7| 4| 5| 7| 7| 6| 6| 7| 7| 7| 5| 6| 6| 7| 6| 7| 4| 7| 7| 7| 7| 7|            |
                             DAY ON TEST   | 0| 4| 9| 2| 0| 3| 3| 3| 6| 3| 3| 0| 3| 7| 6| 6| 3| 9| 1| 0| 1| 3| 1| 3| 3|            |
                                           | 4| 2| 6| 5| 6| 5| 0| 0| 1| 9| 0| 3| 0| 5| 4| 0| 0| 5| 8| 3| 2| 0| 8| 0| 0|      T (*) |

 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|      A     |
    37 MG/KG                               | 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |

 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |

                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Parasite Metazoan                    |                                                                          |      2     |

                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Parasite Metazoan                    |                   X                                      X  X            |      3     |

                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |

                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Ulcer                                |                                                                          |      1  1.0|

                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inflammation, Chronic, Focal         |                                                                          |      1  2.0|

                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |

                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Basophilic Focus                     |    X  X     X     X  X  X           X           X        X     X  X     X|     21     |
      Clear Cell Focus                     |                                                                          |      3     |
      Degeneration, Cystic, Focal          |                                                                         1|      2  1.0|
      Eosinophilic Focus                   | X  X  X  X  X        X  X        X              X              X  X     X|     28     |
      Hepatodiaphragmatic Nodule           |                                                                          |      1     |
      Mixed Cell Focus                     |                X     X                                                   |      7     |
      Necrosis, Focal                      |                                           4                              |      2  2.5|
      Bile Duct, Hyperplasia               |                         1     1  1     2        1              1  1      |     17  1.2|
      Centrilobular, Degeneration          |                                  3                                       |      1  3.0|
      Centrilobular, Necrosis              |                                        3                                 |      4  2.5|
      Hepatocyte, Hypertrophy              |    1  1                 1                                2              2|     13  1.7|
      Oval Cell, Hyperplasia               |    2  1  2              1  3           1                                1|     17  1.5|

                                            __________________________________________________________________________|____________|
   Mesentery                               |                            +  +     +           +                        |   6        |
      Fat, Necrosis                        |                            2  3     2           2                        |      6  2.2|

                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia, Focal                   |                               1     1                                    |      2  1.0|
      Acinus, Atrophy                      |                      1     1     2     1  1        1           1         |     15  1.2|
      Acinus, Hyperplasia, Focal           |             1                                                            |      1  1.0|

                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Submandibular Gland, Cytoplasmic     |                                                                          |            |
          Alteration                       | 2  2  2  2  2  2  2  2  2  2  2  2  2  2  2  2  2  2  2  2  2  2  2  2  2|     50  2.0|

                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Ulcer                                |                               3                                          |      1  3.0|

                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Atrophy                              |          2           2              2     1        1              1  1   |     14  1.6|
      Inflammation, Focal, Suppurative     |                               2                                          |      3  1.7|
      Mineralization                       | 3     3                                                                  |      4  2.0|

 __________________________________________________________________________________________________________________________________ 

  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
NTP Experiment-Test: 05187-09                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           METHYLEUGENOL                                       Date: 07/20/98  
Route: GAVAGE                                                                                                     Time: 09:02:53  
                                                                                                                                    

 __________________________________________________________________________________________________________________________________ 
                                           | 7| 5| 5| 7| 4| 5| 7| 7| 6| 6| 7| 7| 7| 5| 6| 6| 7| 6| 7| 4| 7| 7| 7| 7| 7|            |
                             DAY ON TEST   | 0| 4| 9| 2| 0| 3| 3| 3| 6| 3| 3| 0| 3| 7| 6| 6| 3| 9| 1| 0| 1| 3| 1| 3| 3|            |
                                           | 4| 2| 6| 5| 6| 5| 0| 0| 1| 9| 0| 3| 0| 5| 4| 0| 0| 5| 8| 3| 2| 0| 8| 0| 0|      T (*) |

 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|      A     |
    37 MG/KG                               | 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |

 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
                                           |                                                                          |            |
      Ulcer                                |                                           2                              |      2  2.5|

                                            __________________________________________________________________________|____________|
   Tongue                                  |       +  +                                                               |   2        |

 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Blood Vessel                            | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Mineralization                       |       3                                                                  |      2  2.5|

                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inflammation, Focal, Suppurative     |                                                                          |      1  2.0|
      Atrium, Thrombosis                   |                                  3     3                             2   |      5  2.6|
      Endocardium, Fibrosis                |                                                                          |      1  2.0|
      Myocardium, Degeneration             | 2     2  1  1  3  1  1  1  2  1  2  1  1  1  2  2  1  1  2  1  2     1  2|     41  1.5|
      Myocardium, Mineralization           | 2     3                                                                  |      2  2.5|
      Valve, Thrombosis                    |                                                                          |      1  2.0|

 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia, Focal                   |                            2  1           1     1           1           2|     12  1.3|
      Necrosis                             |                                                                          |      1  3.0|

                                            __________________________________________________________________________|____________|
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia, Focal                   |       4  1     4  3  1                             1  1           2      |     20  2.1|
      Hyperplasia                          |                                                                          |      1  4.0|

                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia                          |                      2                    1                              |      4  1.5|

                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Hyperplasia                          |                                                                          |      2  1.0|
      Bilateral, Hyperplasia               | 1     3  3        1                                                      |      6  1.7|

                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Pars Distalis, Hyperplasia, Focal    |       2                                1                    1        1  1|      9  1.3|

                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      C-Cell, Hyperplasia                  |    2                 1  2           2        2  1  2        1  1     2  2|     25  1.6|
      Follicle, Cyst                       |                                                                         1|      1  1.0|

 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Peritoneum                              |                                  +                                       |   1        |

 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Epididymis                              | +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |

                                            __________________________________________________________________________|____________|
   Preputial Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cyst                                 |          3                       3                                       |      2  3.0|

 __________________________________________________________________________________________________________________________________ 

  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
NTP Experiment-Test: 05187-09                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           METHYLEUGENOL                                       Date: 07/20/98  
Route: GAVAGE                                                                                                     Time: 09:02:53  
                                                                                                                                    

 __________________________________________________________________________________________________________________________________ 
                                           | 7| 5| 5| 7| 4| 5| 7| 7| 6| 6| 7| 7| 7| 5| 6| 6| 7| 6| 7| 4| 7| 7| 7| 7| 7|            |
                             DAY ON TEST   | 0| 4| 9| 2| 0| 3| 3| 3| 6| 3| 3| 0| 3| 7| 6| 6| 3| 9| 1| 0| 1| 3| 1| 3| 3|            |
                                           | 4| 2| 6| 5| 6| 5| 0| 0| 1| 9| 0| 3| 0| 5| 4| 0| 0| 5| 8| 3| 2| 0| 8| 0| 0|      T (*) |

 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|      A     |
    37 MG/KG                               | 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |

 __________________________________________________________________________________________________________________________________ 
 GENITAL SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
      Hyperplasia, Focal                   |                                                                          |      4  2.5|
      Inflammation, Chronic                | 4     1     1           1                 2        2                 1   |     14  1.6|
      Inflammation, Chronic Active         |                                                                          |      1  3.0|

                                            __________________________________________________________________________|____________|
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia, Focal                   |                                                             1            |      1  1.0|
      Inflammation, Chronic                | 1     1     1  2  2           3              1  1        1               |     18  1.3|

                                            __________________________________________________________________________|____________|
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inflammation, Suppurative            |                                                                          |      1  2.0|

                                            __________________________________________________________________________|____________|
   Testes                                  | +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Germinal Epithelium, Atrophy         |                               2                                          |      1  2.0|

 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia                          |    1        2        1  1           1                             2     1|     14  1.4|
      Necrosis                             |                                        2                                 |      2  1.5|

                                            __________________________________________________________________________|____________|
   Lymph Node                              |                                           +           +              +   |   4        |

                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |

                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |

                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Congestion                           |                                                                   2      |      1  2.0|
      Fibrosis                             |       3              1              2     2  1  1     1        2         |     11  1.7|
      Hematopoietic Cell Proliferation     |    2        4                          2  3                             3|      9  2.7|

                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  M  +  M  +  +  +  +  M|  45        |

 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Dilatation                           |                               2              2     1        1        1  1|     13  1.3|
      Hyperplasia, Focal                   |                                  4                                       |      1  4.0|

                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Dermis, Inflammation, Focal,         |                                                                          |            |
          Suppurative                      |                                                                          |      1  3.0|

 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Fibrous Osteodystrophy               | 1     1                                                                  |      2  1.0|
      Osteopetrosis                        |                                                                          |      2  3.0|

                                            __________________________________________________________________________|____________|
   Skeletal Muscle                         |             +                                                            |   1        |

 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |

 __________________________________________________________________________________________________________________________________ 

  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
NTP Experiment-Test: 05187-09                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           METHYLEUGENOL                                       Date: 07/20/98  
Route: GAVAGE                                                                                                     Time: 09:02:53  
                                                                                                                                    

 __________________________________________________________________________________________________________________________________ 
                                           | 7| 5| 5| 7| 4| 5| 7| 7| 6| 6| 7| 7| 7| 5| 6| 6| 7| 6| 7| 4| 7| 7| 7| 7| 7|            |
                             DAY ON TEST   | 0| 4| 9| 2| 0| 3| 3| 3| 6| 3| 3| 0| 3| 7| 6| 6| 3| 9| 1| 0| 1| 3| 1| 3| 3|            |
                                           | 4| 2| 6| 5| 6| 5| 0| 0| 1| 9| 0| 3| 0| 5| 4| 0| 0| 5| 8| 3| 2| 0| 8| 0| 0|      T (*) |

 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|      A     |
    37 MG/KG                               | 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |

 __________________________________________________________________________________________________________________________________ 
 NERVOUS SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hydrocephalus                        |                               3                                          |      3  3.0|
      Necrosis, Focal                      |                                                                          |      2  1.5|
      Hypothalamus, Degeneration           |                               3                                          |      1  3.0|

                                            __________________________________________________________________________|____________|
   Peripheral Nerve                        |                                              +                           |   1        |

                                            __________________________________________________________________________|____________|
   Spinal Cord                             |                                              +                           |   1        |

 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Erythrophagocytosis                  |                                                                          |      1  3.0|
      Inflammation, Suppurative            | 3  1                                                                     |      3  2.3|
      Alveolar Epithelium, Hyperplasia,    |                                                                          |            |
           Focal                           |                      2                                                   |      1  2.0|
      Interstitium, Inflammation, Chronic  |                                  1                                       |      1  1.0|
      Interstitium, Mineralization         |       2                                                                  |      1  2.0|
      Perivascular, Edema                  |                                                                          |      1  3.0|

                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inflammation, Suppurative            |    1  1  2     1  1  1     1     4                 2              1      |     14  1.4|

                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |

 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Eye                                     |                                                                          |   1        |
      Cornea, Inflammation, Chronic        |                                                                          |      1  1.0|

                                            __________________________________________________________________________|____________|
   Zymbal's Gland                          |    +                                                                     |   2        |

 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inflammation, Focal, Suppurative     |                                                                          |      1  2.0|
      Nephropathy                          | 4  1  4  4     1  3  3  1     3  2  2     2  2  2  2  1  2  3  2  1  3  3|     46  2.4|
      Renal Tubule, Cyst                   |          3                                                               |      2  3.0|
      Renal Tubule, Hyperplasia, Focal     |                   4                                                      |      1  4.0|

                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Ulcer                                |                                              3                           |      1  3.0|

 __________________________________________________________________________________________________________________________________ 

  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
NTP Experiment-Test: 05187-09                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           METHYLEUGENOL                                       Date: 07/20/98  
Route: GAVAGE                                                                                                     Time: 09:02:53  
                                                                                                                                    

 _____________________________________________________________________________________________________________________              
                                           | 4| 6| 7| 6| 6| 6| 6| 6| 7| 7| 6| 6| 7| 4| 6| 5| 5| 7| 6| 7| 6| 7| 5| 5| 5|             
                             DAY ON TEST   | 6| 5| 3| 6| 6| 3| 1| 5| 3| 3| 5| 3| 3| 3| 9| 9| 6| 3| 4| 3| 4| 3| 9| 2| 7|             
                                           | 7| 9| 0| 4| 1| 8| 9| 8| 0| 0| 1| 9| 0| 8| 6| 5| 8| 0| 2| 0| 2| 0| 6| 1| 2|             

 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    75 MG/KG                               | 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             

 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Perforation                          |                      X                                                   |             
      Periesophageal Tissue, Inflammation  |                                                                          |             

                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Parasite Metazoan                    |                   X                                                     X|             

                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +|             
      Parasite Metazoan                    |       X                                            X              X  X  X|             

                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Basophilic Focus                     | X     X  X     X        X  X     X           X     X  X  X     X     X   |             
      Clear Cell Focus                     |             X  X                             X        X                  |             
      Degeneration, Cystic, Focal          |    1  2     1        1  2        1           1  1     1  1     1         |             
      Eosinophilic Focus                   | X  X  X  X  X  X  X     X  X        X     X  X  X  X  X  X  X  X  X     X|             
      Mixed Cell Focus                     |       X           X  X           X  X  X                                X|             
      Necrosis, Focal                      |                                              1                 1  2      |             
      Bile Duct, Hyperplasia, Atypical,    |                                                                          |             
           Focal                           |                                        3                                 |             
      Bile Duct, Hyperplasia               |    1        1           3  1     2  2        1        1        1        2|             
      Centrilobular, Degeneration, Fatty   |                                                                   3      |             
      Hepatocyte, Hypertrophy              | 2  2  1        3  2     3  2        4  3           3  2  3     4  3     4|             
      Oval Cell, Hyperplasia               | 2  2  1        1  1  1  2        2  2  1     2  1     1     2     1     2|             

                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Focal                   |                                                                          |             
      Acinus, Atrophy                      |    1           1                                      1  2     1         |             

                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Parotid Gland, Atrophy               |                   2                                                      |             
      Submandibular Gland, Cytoplasmic     |                                                                          |             
          Alteration                       | 2  2  2  2  2  2  2  2  2  2  2  2  2  2  2  2  2     2  2  2  2  2  2  2|             
      Submandibular Gland, Fibrosis        |                   1                                                      |             

                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperkeratosis                       |                                     2                                    |             
      Mineralization                       |                                                          1               |             

                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |    1  1  2  2     2  1  2  2     2     1     2  1  1  3  3  2  2     1  1|             
      Mineralization                       |                3                    3     2  2  2  1     3               |             
      Ulcer                                |          1                                                     2  2      |             
      Neuroendocrine Cell, Hyperplasia     |                                                                          |             

 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Blood Vessel                            | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Mineralization                       |                3                             3  4                        |             

 _____________________________________________________________________________________________________________________|             
NTP Experiment-Test: 05187-09                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           METHYLEUGENOL                                       Date: 07/20/98  
Route: GAVAGE                                                                                                     Time: 09:02:53  
                                                                                                                                    

 _____________________________________________________________________________________________________________________              
                                           | 4| 6| 7| 6| 6| 6| 6| 6| 7| 7| 6| 6| 7| 4| 6| 5| 5| 7| 6| 7| 6| 7| 5| 5| 5|             
                             DAY ON TEST   | 6| 5| 3| 6| 6| 3| 1| 5| 3| 3| 5| 3| 3| 3| 9| 9| 6| 3| 4| 3| 4| 3| 9| 2| 7|             
                                           | 7| 9| 0| 4| 1| 8| 9| 8| 0| 0| 1| 9| 0| 8| 6| 5| 8| 0| 2| 0| 2| 0| 6| 1| 2|             

 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    75 MG/KG                               | 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             

 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |             
                                           |                                                                          |             
      Aorta, Mineralization                |          1                          4                    4               |             

                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrium, Thrombosis                   |                                                          4        3      |             
      Myocardium, Degeneration             | 1  2  3  2        2  2        2  2  3  2     2  2     1  2  1  1  2  1  1|             
      Myocardium, Mineralization           |                2                    2     2  2  1        3               |             

 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Focal                   |    1  1                    2                             1     1         |             

                                            __________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hematocyst                           |                                                    4                     |             
      Hyperplasia, Focal                   |       1  3  1  1        2  3  3                 3  2     2  1  2  1  1   |             

                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                                 1                        |             

                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  +  M  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                           4                              |             
      Bilateral, Hyperplasia               |          1              2  2        4        4  4  3     4     2         |             

                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Focal                   |                                                                          |             
      Pars Distalis, Hyperplasia, Focal    |                         1        2                 1                 1   |             
      Rathke's Cleft, Cyst                 |                            3                                             |             

                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      C-Cell, Hyperplasia                  |       2        1  1     1  1     1  1              2  2  1  1        2   |             

 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Peritoneum                              |                   +                                               +      |             

 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +|             
      Fibrosis                             |                                                                3         |             

                                            __________________________________________________________________________|             
   Preputial Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Focal                   |                                                             1        3   |             
      Inflammation, Chronic                | 1              1           2                                2  1        1|             

                                            __________________________________________________________________________|             
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                                                          |             
      Inflammation, Chronic                | 2        1     3     2                 2              2              1   |             

                                            __________________________________________________________________________|             
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Suppurative            |          1                                                               |             
      Mineralization                       |                                                 3                        |             

                                            __________________________________________________________________________|             
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +|             

 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrosis                             |                2                                                         |             

 _____________________________________________________________________________________________________________________|             
NTP Experiment-Test: 05187-09                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           METHYLEUGENOL                                       Date: 07/20/98  
Route: GAVAGE                                                                                                     Time: 09:02:53  
                                                                                                                                    

 _____________________________________________________________________________________________________________________              
                                           | 4| 6| 7| 6| 6| 6| 6| 6| 7| 7| 6| 6| 7| 4| 6| 5| 5| 7| 6| 7| 6| 7| 5| 5| 5|             
                             DAY ON TEST   | 6| 5| 3| 6| 6| 3| 1| 5| 3| 3| 5| 3| 3| 3| 9| 9| 6| 3| 4| 3| 4| 3| 9| 2| 7|             
                                           | 7| 9| 0| 4| 1| 8| 9| 8| 0| 0| 1| 9| 0| 8| 6| 5| 8| 0| 2| 0| 2| 0| 6| 1| 2|             

 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    75 MG/KG                               | 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             

 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Hyperplasia                          |    2     1     1  2     1  1        1              1  2  1     1  1     1|             
      Necrosis                             |             2                                                            |             

                                            __________________________________________________________________________|             
   Lymph Node                              |                               +                             +            |             
      Mediastinal, Inflammation,           |                                                                          |             
          Suppurative                      |                                                                          |             

                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Suppurative            |                                                                          |             

                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Congestion                           |                                                                   3      |             
      Fibrosis                             |       1  4     2           1                             2     2         |             
      Hematopoietic Cell Proliferation     |                2  1                                                      |             

                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  +  +  M  +  M  +  +  +  +  +  +  +  M  +  +|             

 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +|             
      Dilatation                           | 2        1                                                               |             

                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Subcutaneous Tissue, Necrosis        |                                              4                           |             

 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrous Osteodystrophy               |                                     4     3  3  4  1     2               |             

 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hydrocephalus                        |                         2  3                                             |             
      Necrosis, Focal                      |                      2                                                   |             
      Hypothalamus, Degeneration           |                                                                          |             

                                            __________________________________________________________________________|             
   Peripheral Nerve                        |                                  +                                       |             

                                            __________________________________________________________________________|             
   Spinal Cord                             |                                  +                                       |             

 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage, Focal                    |                                                                          |             
      Infiltration Cellular, Histiocyte    |                                                                   2      |             
      Inflammation, Granulomatous          |                                                       1                  |             
      Inflammation, Suppurative            |                      2                          2                        |             
      Alveolar Epithelium, Hyperplasia,    |                                                                          |             
           Focal                           |                                                                          |             
      Alveolar Epithelium, Interstitium,   |                                                                          |             
           Mineralization                  |                                                 3                        |             
      Bronchiole, Inflammation, Suppurative|                                  1                                       |             
      Interstitium, Inflammation, Chronic  |                                                                          |             

 _____________________________________________________________________________________________________________________|             
NTP Experiment-Test: 05187-09                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           METHYLEUGENOL                                       Date: 07/20/98  
Route: GAVAGE                                                                                                     Time: 09:02:53  
                                                                                                                                    

 _____________________________________________________________________________________________________________________              
                                           | 4| 6| 7| 6| 6| 6| 6| 6| 7| 7| 6| 6| 7| 4| 6| 5| 5| 7| 6| 7| 6| 7| 5| 5| 5|             
                             DAY ON TEST   | 6| 5| 3| 6| 6| 3| 1| 5| 3| 3| 5| 3| 3| 3| 9| 9| 6| 3| 4| 3| 4| 3| 9| 2| 7|             
                                           | 7| 9| 0| 4| 1| 8| 9| 8| 0| 0| 1| 9| 0| 8| 6| 5| 8| 0| 2| 0| 2| 0| 6| 1| 2|             

 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    75 MG/KG                               | 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             

 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
      Interstitium, Mineralization         |                2                    3        2           3               |             
      Perivascular, Edema                  |                                                                          |             

                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Suppurative            |       1  1  2  1     1  2  2  2  1  1  1        1  1     2  1     1      |             

                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Eye                                     |                                  +  +                                    |             
      Cataract                             |                                     3                                    |             
      Degeneration                         |                                  4                                       |             
      Retina, Atrophy                      |                                     3                                    |             

 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hydronephrosis                       |          3                                                               |             
      Inflammation, Focal, Suppurative     |                                                                          |             
      Nephropathy                          | 1  3  3  4  2  3  2  2  3  3     2  4  1  4  4  4  3  2  4  1  4  3  1  1|             
      Renal Tubule, Hyperplasia, Focal     |       3                                            2                     |             

                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +|             
      Ulcer                                |          4                                                               |             

 _____________________________________________________________________________________________________________________|             
NTP Experiment-Test: 05187-09                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           METHYLEUGENOL                                       Date: 07/20/98  
Route: GAVAGE                                                                                                     Time: 09:02:53  
                                                                                                                                    

 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 5| 7| 6| 7| 6| 7| 6| 7| 7| 5| 0| 6| 6| 5| 7| 6| 6| 6| 6| 6|            |
                             DAY ON TEST   | 3| 3| 0| 3| 1| 8| 3| 0| 3| 9| 3| 3| 3| 3| 0| 1| 9| 7| 2| 0| 7| 9| 9| 9| 1|            |
                                           | 0| 0| 9| 0| 2| 2| 0| 1| 0| 5| 0| 0| 0| 0| 2| 5| 5| 4| 2| 6| 3| 2| 5| 6| 0|      T (*) |

 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|      A     |
    75 MG/KG                               | 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |

 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Perforation                          |                                                                          |      1     |
      Periesophageal Tissue, Inflammation  |                                              2                           |      1  2.0|

                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Parasite Metazoan                    |                            X              X           X                  |      5     |

                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Parasite Metazoan                    |                                                                          |      5     |

                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |

                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |

                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |

                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |

                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Basophilic Focus                     |    X     X     X  X           X     X     X                    X     X   |     22     |
      Clear Cell Focus                     |    X  X           X                                                      |      7     |
      Degeneration, Cystic, Focal          |    1     2  1     1  1  1                 1        1     1  3  2  2  2  1|     25  1.3|
      Eosinophilic Focus                   | X  X  X  X  X  X  X  X  X  X  X     X  X  X     X  X  X  X  X  X  X  X  X|     43     |
      Mixed Cell Focus                     |       X  X        X                    X  X           X  X               |     14     |
      Necrosis, Focal                      |                                                          2              1|      5  1.4|
      Bile Duct, Hyperplasia, Atypical,    |                                                                          |            |
           Focal                           |                                                                          |      1  3.0|
      Bile Duct, Hyperplasia               | 1  1                 4                                      1        1  2|     16  1.6|
      Centrilobular, Degeneration, Fatty   |                                                                          |      1  3.0|
      Hepatocyte, Hypertrophy              |    1  2  2        3     4     1     3  3  4           4                  |     25  2.7|
      Oval Cell, Hyperplasia               | 1  1                 1  1                 2           2              2  2|     24  1.5|

                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia, Focal                   |                                        2                                 |      1  2.0|
      Acinus, Atrophy                      | 1     1           1  1  2                 1           1                 1|     13  1.2|

                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Parotid Gland, Atrophy               |                                                                          |      1  2.0|
      Submandibular Gland, Cytoplasmic     |                                                                          |            |
          Alteration                       | 2  2  2  2  2  2  2  2  2  2  2  2  2  2  2  2  2  2  2  2  2  2  2  2  2|     49  2.0|
      Submandibular Gland, Fibrosis        |                                                                          |      1  1.0|

                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperkeratosis                       |                                                                          |      1  2.0|
      Mineralization                       |                                                                          |      1  1.0|

                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Atrophy                              | 2  2  1  1  1        3  1  2     2  2  1                 2              2|     32  1.7|
      Mineralization                       |    1  2                                         3  1     1  4  2     4   |     15  2.3|
      Ulcer                                |                                                                          |      3  1.7|

 __________________________________________________________________________________________________________________________________ 

  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
NTP Experiment-Test: 05187-09                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           METHYLEUGENOL                                       Date: 07/20/98  
Route: GAVAGE                                                                                                     Time: 09:02:53  
                                                                                                                                    

 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 5| 7| 6| 7| 6| 7| 6| 7| 7| 5| 0| 6| 6| 5| 7| 6| 6| 6| 6| 6|            |
                             DAY ON TEST   | 3| 3| 0| 3| 1| 8| 3| 0| 3| 9| 3| 3| 3| 3| 0| 1| 9| 7| 2| 0| 7| 9| 9| 9| 1|            |
                                           | 0| 0| 9| 0| 2| 2| 0| 1| 0| 5| 0| 0| 0| 0| 2| 5| 5| 4| 2| 6| 3| 2| 5| 6| 0|      T (*) |

 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|      A     |
    75 MG/KG                               | 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |

 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
                                           |                                                                          |            |
      Neuroendocrine Cell, Hyperplasia     |                         1                                                |      1  1.0|

 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Blood Vessel                            | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Mineralization                       |                                                                          |      3  3.3|
      Aorta, Mineralization                |       2                                         2  3        4  3     4   |      9  3.0|

                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Atrium, Thrombosis                   |                                                          4           4   |      4  3.8|
      Myocardium, Degeneration             |    1  2  2  1  2  1        1  2  2  1     1           1  2        2     1|     34  1.6|
      Myocardium, Mineralization           |                                                 3  2        3  1     3   |     11  2.2|

 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia, Focal                   |                               1                                          |      6  1.2|

                                            __________________________________________________________________________|____________|
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hematocyst                           |                                                                          |      1  4.0|
      Hyperplasia, Focal                   |    3  2              1  4           2              4        1            |     21  2.0|

                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia                          |                                                                          |      1  1.0|

                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Hyperplasia                          |          1                          1  2           4        3            |      6  2.5|
      Bilateral, Hyperplasia               | 1     3           1     2                       3              3     3   |     16  2.6|

                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia, Focal                   |                                           1                              |      1  1.0|
      Pars Distalis, Hyperplasia, Focal    | 1  1     2              1                                                |      8  1.3|
      Rathke's Cleft, Cyst                 |                                                                          |      1  3.0|

                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      C-Cell, Hyperplasia                  | 1        2  1     1  2  1     4     1  1  2                 2     1     2|     25  1.5|

 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Peritoneum                              |                                                                          |   2        |

 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Fibrosis                             |                                                                          |      1  3.0|

                                            __________________________________________________________________________|____________|
   Preputial Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Hyperplasia, Focal                   |    1  1  1  1                                                            |      6  1.3|
      Inflammation, Chronic                |                1                          1                              |      8  1.3|

                                            __________________________________________________________________________|____________|
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |

 __________________________________________________________________________________________________________________________________ 

  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
NTP Experiment-Test: 05187-09                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           METHYLEUGENOL                                       Date: 07/20/98  
Route: GAVAGE                                                                                                     Time: 09:02:53  
                                                                                                                                    

 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 5| 7| 6| 7| 6| 7| 6| 7| 7| 5| 0| 6| 6| 5| 7| 6| 6| 6| 6| 6|            |
                             DAY ON TEST   | 3| 3| 0| 3| 1| 8| 3| 0| 3| 9| 3| 3| 3| 3| 0| 1| 9| 7| 2| 0| 7| 9| 9| 9| 1|            |
                                           | 0| 0| 9| 0| 2| 2| 0| 1| 0| 5| 0| 0| 0| 0| 2| 5| 5| 4| 2| 6| 3| 2| 5| 6| 0|      T (*) |

 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|      A     |
    75 MG/KG                               | 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |

 __________________________________________________________________________________________________________________________________ 
 GENITAL SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
      Hyperplasia                          |                                     4                                    |      1  4.0|
      Inflammation, Chronic                |                1  2                                1  1  2        2      |     13  1.7|

                                            __________________________________________________________________________|____________|
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inflammation, Suppurative            |                                                                   2      |      2  1.5|
      Mineralization                       |                                                                          |      1  3.0|

                                            __________________________________________________________________________|____________|
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |

 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Fibrosis                             |                                                                         2|      2  2.0|
      Hyperplasia                          |    1              1     1  1  2                 1  1  1  1               |     22  1.2|
      Necrosis                             |       2                                                                  |      2  2.0|

                                            __________________________________________________________________________|____________|
   Lymph Node                              |                      +           +                                       |   4        |
      Mediastinal, Inflammation,           |                                                                          |            |
          Suppurative                      |                      3                                                   |      1  3.0|

                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |

                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Inflammation, Suppurative            |                      4                                                   |      1  4.0|

                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Congestion                           |                                                                          |      1  3.0|
      Fibrosis                             | 1     2  1        2           1                       1                  |     12  1.7|
      Hematopoietic Cell Proliferation     |                                                                          |      2  1.5|

                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +  M  +  +  +  M  M  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  43        |

 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Dilatation                           |                               1                                         1|      4  1.3|

                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Subcutaneous Tissue, Necrosis        |                                                                          |      1  4.0|

 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Fibrous Osteodystrophy               |       2                                         2  2        4  3     4   |     12  2.8|

 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hydrocephalus                        |                      4                                                   |      3  3.0|
      Necrosis, Focal                      |                                                                          |      1  2.0|
      Hypothalamus, Degeneration           |                      4                                                   |      1  4.0|

 __________________________________________________________________________________________________________________________________ 

  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
NTP Experiment-Test: 05187-09                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           METHYLEUGENOL                                       Date: 07/20/98  
Route: GAVAGE                                                                                                     Time: 09:02:53  
                                                                                                                                    

 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 5| 7| 6| 7| 6| 7| 6| 7| 7| 5| 0| 6| 6| 5| 7| 6| 6| 6| 6| 6|            |
                             DAY ON TEST   | 3| 3| 0| 3| 1| 8| 3| 0| 3| 9| 3| 3| 3| 3| 0| 1| 9| 7| 2| 0| 7| 9| 9| 9| 1|            |
                                           | 0| 0| 9| 0| 2| 2| 0| 1| 0| 5| 0| 0| 0| 0| 2| 5| 5| 4| 2| 6| 3| 2| 5| 6| 0|      T (*) |

 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|      A     |
    75 MG/KG                               | 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |

 __________________________________________________________________________________________________________________________________ 
 NERVOUS SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Peripheral Nerve                        |                                                                          |   1        |

                                            __________________________________________________________________________|____________|
   Spinal Cord                             |                                                                          |   1        |

 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hemorrhage, Focal                    |                      1                                                   |      1  1.0|
      Infiltration Cellular, Histiocyte    |                                                                          |      1  2.0|
      Inflammation, Granulomatous          |                                                                         1|      2  1.0|
      Inflammation, Suppurative            |                                                                          |      2  2.0|
      Alveolar Epithelium, Hyperplasia,    |                                                                          |            |
           Focal                           |                                                       1                  |      1  1.0|
      Alveolar Epithelium, Interstitium,   |                                                                          |            |
           Mineralization                  |                                                                          |      1  3.0|
      Bronchiole, Inflammation, Suppurative|                                                                          |      1  1.0|
      Interstitium, Inflammation, Chronic  |             1     1                                                      |      2  1.0|
      Interstitium, Mineralization         |       2                                                     3  2     2   |      8  2.4|
      Perivascular, Edema                  |                                                       2                  |      1  2.0|

                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inflammation, Suppurative            |       1              2                                         2     1   |     20  1.4|

                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |

 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Eye                                     |                                                                          |   2        |
      Cataract                             |                                                                          |      1  3.0|
      Degeneration                         |                                                                          |      1  4.0|
      Retina, Atrophy                      |                                                                          |      1  3.0|

 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hydronephrosis                       |                                                          2               |      2  2.5|
      Inflammation, Focal, Suppurative     |             1                                                            |      1  1.0|
      Nephropathy                          | 3  3  4  3  3  1  3  2  3  3  3  2  3  4  1     4  4  2  3  4  4  4  4  2|     48  2.8|
      Renal Tubule, Hyperplasia, Focal     |                   4                 2  1                    4        4   |      7  2.9|

                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Ulcer                                |                                                          4               |      2  4.0|

 __________________________________________________________________________________________________________________________________ 

  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
NTP Experiment-Test: 05187-09                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           METHYLEUGENOL                                       Date: 07/20/98  
Route: GAVAGE                                                                                                     Time: 09:02:53  
                                                                                                                                    

 _____________________________________________________________________________________________________________________              
                                           | 6| 4| 6| 6| 6| 6| 6| 6| 5| 6| 6| 5| 7| 6| 5| 6| 7| 6| 4| 5| 6| 3| 5| 6| 5|             
                             DAY ON TEST   | 3| 6| 3| 8| 5| 6| 7| 4| 7| 0| 2| 9| 1| 5| 4| 8| 0| 5| 9| 9| 9| 3| 8| 8| 8|             
                                           | 8| 7| 3| 0| 8| 9| 0| 2| 5| 0| 1| 8| 2| 9| 7| 3| 0| 0| 5| 8| 9| 7| 4| 0| 3|             

 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    150                                    | 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8|             
    MG/KG                                  | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             

 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Perforation                          |                                                             X            |             

                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Parasite Metazoan                    |                                                                          |             

                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Parasite Metazoan                    |                                                                          |             

                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic, Focal         |                                                                         3|             

                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Mineralization                       |          2                                                               |             

                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Basophilic Focus                     |       X                       X                    X  X        X         |             
      Clear Cell Focus                     |                                                                   X     X|             
      Degeneration, Cystic, Focal          | 3     3  3  3  3  3  2  2     3        3  1  1     1  2  2        1  3  2|             
      Eosinophilic Focus                   | X  X  X  X  X  X  X  X  X  X  X  X  X  X  X  X  X  X  X  X  X  X  X  X  X|             
      Inflammation, Acute                  |                                                                          |             
      Mixed Cell Focus                     |    X                          X           X           X        X        X|             
      Necrosis, Focal                      |                2                          1                              |             
      Bile Duct, Hyperplasia, Atypical,    |                                                                          |             
           Focal                           |                                                                          |             
      Bile Duct, Hyperplasia               |                               2        2                          2     1|             
      Centrilobular, Necrosis              |                         3                                                |             
      Hepatocyte, Hypertrophy              |       3  3  3                 3     3  3  2  3     3  2  3     4        3|             
      Oval Cell, Hyperplasia               | 3  2  1                             1  1  1  1     2  2  1     1  1  1  2|             

                                            __________________________________________________________________________|             
   Mesentery                               |       +                                                                  |             

                                            __________________________________________________________________________|             
   Oral Mucosa                             |       +                                                                  |             

                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Focal                   |                                     3                                    |             
      Acinus, Atrophy                      | 2                                         2  1                    1     1|             

                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic                |       2                                                                  |             
      Submandibular Gland, Cytoplasmic     |                                                                          |             
          Alteration                       | 2  2  2  2  2     2  2  2  2  2  2  2  2  2  2  2  2  2  2  2  2  2  2  2|             

                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic                |    2                                                                     |             
      Mineralization                       |          3        3                                4                     |             

                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |    3  3     2  3  2           2  2  2     2  2                 2  2  3  2|             
      Mineralization                       | 1        3  3     2           1              2     4     4               |             
      Ulcer                                |             2                                                            |             
      Neuroendocrine Cell, Hyperplasia     |                                  1  2        1                           |             

                                            __________________________________________________________________________|             
   Tongue                                  |                                              +                           |             

 _____________________________________________________________________________________________________________________|             
NTP Experiment-Test: 05187-09                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           METHYLEUGENOL                                       Date: 07/20/98  
Route: GAVAGE                                                                                                     Time: 09:02:53  
                                                                                                                                    

 _____________________________________________________________________________________________________________________              
                                           | 6| 4| 6| 6| 6| 6| 6| 6| 5| 6| 6| 5| 7| 6| 5| 6| 7| 6| 4| 5| 6| 3| 5| 6| 5|             
                             DAY ON TEST   | 3| 6| 3| 8| 5| 6| 7| 4| 7| 0| 2| 9| 1| 5| 4| 8| 0| 5| 9| 9| 9| 3| 8| 8| 8|             
                                           | 8| 7| 3| 0| 8| 9| 0| 2| 5| 0| 1| 8| 2| 9| 7| 3| 0| 0| 5| 8| 9| 7| 4| 0| 3|             

 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    150                                    | 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8|             
    MG/KG                                  | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             

 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
                                           |                                                                          |             

 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Blood Vessel                            | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Mineralization                       |                   3                                      4               |             
      Aorta, Mineralization                |          3  3                                1  1  4                     |             

                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrium, Thrombosis                   |                                                                          |             
      Myocardium, Degeneration             |    2  2        2  1  2  1  2  2  1  2     1  2  1     1  2           1  2|             
      Myocardium, Mineralization           | 3           3     1                          1           2               |             
      Valve, Inflammation, Chronic         |                         4                                                |             
      Ventricle, Thrombosis                |                1                                                         |             

 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Focal                   |             1                                                            |             
      Necrosis, Focal                      |                                                                          |             

                                            __________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Focal                   |       1  3     1  2           3     3  4     4     3  1  3  1           2|             

                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  M  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  M  +|             
      Hyperplasia                          |                   2                 2                                    |             
      Bilateral, Hyperplasia               | 3        3  3                                4     4     4  3            |             

                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |             2                                1                           |             
      Pars Distalis, Hyperplasia, Focal    |                                                                   1      |             
      Pars Nervosa, Inflammation, Focal,   |                                                                          |             
           Suppurative                     |                         1                                                |             

                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      C-Cell, Hyperplasia                  |                               1                                      2  2|             

 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Peritoneum                              |             +                                         +                  |             

 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Granuloma Sperm                      |                                                                          |             

                                            __________________________________________________________________________|             
   Preputial Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 | 2        2           3                       3  3                        |             
      Hyperplasia, Focal                   |    1                       1                             4              1|             
      Inflammation, Chronic                |    1  1                                   2           1                 1|             

                                            __________________________________________________________________________|             
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Focal                   |                                     2                                    |             
      Hyperplasia                          |                                                                          |             
      Inflammation, Chronic                | 1  1        2                 2     1           3  1              1     1|             

 _____________________________________________________________________________________________________________________|             
NTP Experiment-Test: 05187-09                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           METHYLEUGENOL                                       Date: 07/20/98  
Route: GAVAGE                                                                                                     Time: 09:02:53  
                                                                                                                                    

 _____________________________________________________________________________________________________________________              
                                           | 6| 4| 6| 6| 6| 6| 6| 6| 5| 6| 6| 5| 7| 6| 5| 6| 7| 6| 4| 5| 6| 3| 5| 6| 5|             
                             DAY ON TEST   | 3| 6| 3| 8| 5| 6| 7| 4| 7| 0| 2| 9| 1| 5| 4| 8| 0| 5| 9| 9| 9| 3| 8| 8| 8|             
                                           | 8| 7| 3| 0| 8| 9| 0| 2| 5| 0| 1| 8| 2| 9| 7| 3| 0| 0| 5| 8| 9| 7| 4| 0| 3|             

 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    150                                    | 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8|             
    MG/KG                                  | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             

 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Suppurative            | 1                             2                 2                        |             
      Epithelium, Atrophy                  |                                                                          |             

                                            __________________________________________________________________________|             
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Germinal Epithelium, Atrophy         |       4                          4                                       |             

 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |       2     2           1  1  1  1        1        1  2  1  2     1     1|             
      Necrosis                             |                                        2                                 |             

                                            __________________________________________________________________________|             
   Lymph Node                              |                                        +                                 |             
      Lumbar, Hyperplasia, Lymphoid        |                                                                          |             
      Mediastinal, Erythrophagocytosis     |                                        1                                 |             

                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Erythrophagocytosis                  |                                        2                                 |             

                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Congestion                           |                            3                                             |             
      Fibrosis                             |          3                          2  2        2  1                     |             
      Hematopoietic Cell Proliferation     |                         2     3           3           2                 1|             
      Hemorrhage                           |                            4                                             |             

                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  M  +  +  +  +  +|             

 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  M|             
      Dilatation                           |                         1                          2     1               |             
      Hyperplasia, Focal                   |                                                                          |             

                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Edema                                |                                        4                                 |             

 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrous Osteodystrophy               | 1        3  3     4                          2     3     3               |             

 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hydrocephalus                        |                                                                          |             
      Necrosis, Focal                      |                                                                          |             

 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Granulomatous          |                                                                          |             
      Inflammation, Suppurative            |                                                             1            |             
      Alveolar Epithelium, Hyperplasia,    |                                                                          |             

 _____________________________________________________________________________________________________________________|             
NTP Experiment-Test: 05187-09                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           METHYLEUGENOL                                       Date: 07/20/98  
Route: GAVAGE                                                                                                     Time: 09:02:53  
                                                                                                                                    

 _____________________________________________________________________________________________________________________              
                                           | 6| 4| 6| 6| 6| 6| 6| 6| 5| 6| 6| 5| 7| 6| 5| 6| 7| 6| 4| 5| 6| 3| 5| 6| 5|             
                             DAY ON TEST   | 3| 6| 3| 8| 5| 6| 7| 4| 7| 0| 2| 9| 1| 5| 4| 8| 0| 5| 9| 9| 9| 3| 8| 8| 8|             
                                           | 8| 7| 3| 0| 8| 9| 0| 2| 5| 0| 1| 8| 2| 9| 7| 3| 0| 0| 5| 8| 9| 7| 4| 0| 3|             

 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    150                                    | 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8|             
    MG/KG                                  | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             

 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
           Focal                           |                         2                                                |             
      Alveolar Epithelium, Interstitium,   |                                                                          |             
           Mineralization                  |                                                          2               |             
      Bronchus, Inflammation, Suppurative  |                                                                         3|             
      Interstitium, Inflammation, Chronic  |                                                                   1      |             
      Interstitium, Mineralization         |          2  2                                2     2                     |             

                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Suppurative            | 1  1                                   1     2  2              1         |             

                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Eye                                     |                                                                          |             
      Cataract                             |                                                                          |             

                                            __________________________________________________________________________|             
   Zymbal's Gland                          |                                                                          |             

 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Focal, Suppurative     |                3        2                                                |             
      Nephropathy                          | 4  2  3  4  4  4  4  2  3  4  3  4  3  3  3  4  3  4  1  4  3  1  2  3  2|             
      Renal Tubule, Hyperplasia, Focal     |                                                                          |             
      Renal Tubule, Hyperplasia, Oncocytic |                                                                          |             

                                            __________________________________________________________________________|             
   Urethra                                 |                                                                      +   |             

                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

 _____________________________________________________________________________________________________________________|             
NTP Experiment-Test: 05187-09                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           METHYLEUGENOL                                       Date: 07/20/98  
Route: GAVAGE                                                                                                     Time: 09:02:53  
                                                                                                                                    

 __________________________________________________________________________________________________________________________________ 
                                           | 6| 6| 5| 4| 5| 6| 6| 6| 6| 4| 6| 6| 6| 6| 6| 6| 7| 6| 6| 5| 6| 6| 6| 5| 6|            |
                             DAY ON TEST   | 1| 6| 4| 5| 6| 1| 2| 4| 8| 0| 4| 4| 0| 8| 5| 0| 0| 6| 6| 0| 6| 8| 4| 2| 6|            |
                                           | 4| 1| 6| 7| 8| 0| 5| 2| 8| 9| 2| 8| 2| 8| 4| 7| 4| 0| 0| 2| 0| 4| 6| 3| 0|      T (*) |

 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|      A     |
    150                                    | 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1|      L     |
    MG/KG                                  | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |

 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Perforation                          |                                                                          |      1     |

                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Parasite Metazoan                    |             X                                                            |      1     |

                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Parasite Metazoan                    |                X  X                                      X  X            |      4     |

                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |

                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |

                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inflammation, Chronic, Focal         |                                                                          |      1  3.0|

                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Mineralization                       |                                                                          |      1  2.0|

                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Basophilic Focus                     |                   X                                X                     |      7     |
      Clear Cell Focus                     |                X                                                         |      3     |
      Degeneration, Cystic, Focal          |    1     3        1  2  3  2  2  2  2  2  2  2  3     3  1  1  2  3  1  3|     38  2.2|
      Eosinophilic Focus                   | X  X     X  X  X  X  X  X  X  X  X     X  X  X  X  X  X  X  X  X     X  X|     47     |
      Inflammation, Acute                  |                         2                                                |      1  2.0|
      Mixed Cell Focus                     |    X     X                                                               |      8     |
      Necrosis, Focal                      |       2                                                                  |      3  1.7|
      Bile Duct, Hyperplasia, Atypical,    |                                                                          |            |
           Focal                           |                                                       2  1               |      2  1.5|
      Bile Duct, Hyperplasia               | 1  2           2  1  2  1     1  2     2  1           4           2     3|     17  1.8|
      Centrilobular, Necrosis              |                                                                          |      1  3.0|
      Hepatocyte, Hypertrophy              |    3     4  2     2  3  3  2  2           2  4  3  2  2  4     2  3     3|     30  2.8|
      Oval Cell, Hyperplasia               |    2     2  2  3  2  2     1  2     1  1  3  2  3  1  2  2  1  2  2     3|     34  1.7|

                                            __________________________________________________________________________|____________|
   Mesentery                               |                                                                          |   1        |

                                            __________________________________________________________________________|____________|
   Oral Mucosa                             |                                                                          |   1        |

                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia, Focal                   |                                                       4                  |      2  3.5|
      Acinus, Atrophy                      |             1                 1     1                    1               |      9  1.2|

                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Inflammation, Chronic                |                                                                          |      1  2.0|
      Submandibular Gland, Cytoplasmic     |                                                                          |            |
          Alteration                       | 2  2  2  2  2  2  2  2  2  2  2     2  2  2  2  2  2  2  2  2  2  2  2  2|     48  2.0|

                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inflammation, Chronic                |                                                                          |      1  2.0|
      Mineralization                       |             2                                                     3     3|      6  3.0|

                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |

 __________________________________________________________________________________________________________________________________ 

  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
NTP Experiment-Test: 05187-09                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           METHYLEUGENOL                                       Date: 07/20/98  
Route: GAVAGE                                                                                                     Time: 09:02:53  
                                                                                                                                    

 __________________________________________________________________________________________________________________________________ 
                                           | 6| 6| 5| 4| 5| 6| 6| 6| 6| 4| 6| 6| 6| 6| 6| 6| 7| 6| 6| 5| 6| 6| 6| 5| 6|            |
                             DAY ON TEST   | 1| 6| 4| 5| 6| 1| 2| 4| 8| 0| 4| 4| 0| 8| 5| 0| 0| 6| 6| 0| 6| 8| 4| 2| 6|            |
                                           | 4| 1| 6| 7| 8| 0| 5| 2| 8| 9| 2| 8| 2| 8| 4| 7| 4| 0| 0| 2| 0| 4| 6| 3| 0|      T (*) |

 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|      A     |
    150                                    | 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1|      L     |
    MG/KG                                  | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |

 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
                                           |                                                                          |            |
      Atrophy                              | 2  2  2  2  2  3     3  2  2  3     1  1  3  2  3  2  4  3  3  1  1  1  3|     37  2.2|
      Mineralization                       |    1                    2                          2              4  2  2|     14  2.4|
      Ulcer                                |                                                    1                     |      2  1.5|
      Neuroendocrine Cell, Hyperplasia     |    1                 2              2  1        2                        |      8  1.5|

                                            __________________________________________________________________________|____________|
   Tongue                                  |                                                                          |   1        |

 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Blood Vessel                            | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Mineralization                       |             2                                   4  3              4     3|      7  3.3|
      Aorta, Mineralization                |                         1                                                |      6  2.2|

                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Atrium, Thrombosis                   |                               1                          4               |      2  2.5|
      Myocardium, Degeneration             | 1  2  1  1  2  2        2  1     2  1        2  1  2  2  2  2  3  2  1  1|     37  1.6|
      Myocardium, Mineralization           |                                                 1  3              3     2|      9  2.1|
      Valve, Inflammation, Chronic         |                                                                          |      1  4.0|
      Ventricle, Thrombosis                |                                                                          |      1  1.0|

 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia, Focal                   |    1                 1                    1                              |      4  1.0|
      Necrosis, Focal                      |                                  1                                       |      1  1.0|

                                            __________________________________________________________________________|____________|
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia, Focal                   |    3     1     1              1  3              3        4              3|     21  2.4|

                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |

                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +  +  +  M  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +|  45        |
      Hyperplasia                          |                                                    4                     |      3  2.7|
      Bilateral, Hyperplasia               |    3        1           3              2  1     3     2     3  4  4     4|     18  3.0|

                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Angiectasis                          |                                                                          |      2  1.5|
      Pars Distalis, Hyperplasia, Focal    |                                                             1            |      2  1.0|
      Pars Nervosa, Inflammation, Focal,   |                                                                          |            |
           Suppurative                     |                                                                          |      1  1.0|

                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      C-Cell, Hyperplasia                  |                      2        2           1     1        1  2  1         |     10  1.5|

 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Peritoneum                              |          +        +        +                 +                           |   6        |

 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |

 __________________________________________________________________________________________________________________________________ 

  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
NTP Experiment-Test: 05187-09                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           METHYLEUGENOL                                       Date: 07/20/98  
Route: GAVAGE                                                                                                     Time: 09:02:53  
                                                                                                                                    

 __________________________________________________________________________________________________________________________________ 
                                           | 6| 6| 5| 4| 5| 6| 6| 6| 6| 4| 6| 6| 6| 6| 6| 6| 7| 6| 6| 5| 6| 6| 6| 5| 6|            |
                             DAY ON TEST   | 1| 6| 4| 5| 6| 1| 2| 4| 8| 0| 4| 4| 0| 8| 5| 0| 0| 6| 6| 0| 6| 8| 4| 2| 6|            |
                                           | 4| 1| 6| 7| 8| 0| 5| 2| 8| 9| 2| 8| 2| 8| 4| 7| 4| 0| 0| 2| 0| 4| 6| 3| 0|      T (*) |

 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|      A     |
    150                                    | 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1|      L     |
    MG/KG                                  | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |

 __________________________________________________________________________________________________________________________________ 
 GENITAL SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Granuloma Sperm                      |                                                                      2   |      1  2.0|

                                            __________________________________________________________________________|____________|
   Preputial Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cyst                                 |                                                                         1|      6  2.3|
      Hyperplasia, Focal                   |                                                                          |      4  1.8|
      Inflammation, Chronic                |       1  2  1              2        1        1           2               |     12  1.3|

                                            __________________________________________________________________________|____________|
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +|  49        |
      Hyperplasia, Focal                   |                                                                          |      1  2.0|
      Hyperplasia                          |                                                                4         |      1  4.0|
      Inflammation, Chronic                |    1  1     4                          2        1              2         |     15  1.6|

                                            __________________________________________________________________________|____________|
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inflammation, Suppurative            |             3                                   2                       2|      6  2.0|
      Epithelium, Atrophy                  |                                                                      2   |      1  2.0|

                                            __________________________________________________________________________|____________|
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Germinal Epithelium, Atrophy         |                                                          2               |      3  3.3|

 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia                          |    1     2        1        1  2           1        1  1  2     1         |     23  1.3|
      Necrosis                             |                                                                          |      1  2.0|

                                            __________________________________________________________________________|____________|
   Lymph Node                              |       +                    +     +                                       |   4        |
      Lumbar, Hyperplasia, Lymphoid        |                            2                                             |      1  2.0|
      Mediastinal, Erythrophagocytosis     |                                                                          |      1  1.0|

                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |

                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Erythrophagocytosis                  |                                                                          |      1  2.0|

                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Congestion                           |                                                                          |      1  3.0|
      Fibrosis                             |                               2  1     2  2     2           2           2|     12  1.9|
      Hematopoietic Cell Proliferation     |          4        2     2  2                 2     2     2     2         |     13  2.2|
      Hemorrhage                           |                                                                          |      1  4.0|

                                            __________________________________________________________________________|____________|
   Thymus                                  | M  M  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  M  M  +  +  +  M  +  +|  42        |

 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Mammary Gland                           | M  +  +  +  +  M  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  45        |
      Dilatation                           |                                     2  2  1                    1         |      7  1.4|
      Hyperplasia, Focal                   |                                                                         4|      1  4.0|

                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Edema                                |                                                                          |      1  4.0|

 __________________________________________________________________________________________________________________________________ 

  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
NTP Experiment-Test: 05187-09                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           METHYLEUGENOL                                       Date: 07/20/98  
Route: GAVAGE                                                                                                     Time: 09:02:53  
                                                                                                                                    

 __________________________________________________________________________________________________________________________________ 
                                           | 6| 6| 5| 4| 5| 6| 6| 6| 6| 4| 6| 6| 6| 6| 6| 6| 7| 6| 6| 5| 6| 6| 6| 5| 6|            |
                             DAY ON TEST   | 1| 6| 4| 5| 6| 1| 2| 4| 8| 0| 4| 4| 0| 8| 5| 0| 0| 6| 6| 0| 6| 8| 4| 2| 6|            |
                                           | 4| 1| 6| 7| 8| 0| 5| 2| 8| 9| 2| 8| 2| 8| 4| 7| 4| 0| 0| 2| 0| 4| 6| 3| 0|      T (*) |

 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|      A     |
    150                                    | 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1|      L     |
    MG/KG                                  | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |

 __________________________________________________________________________________________________________________________________ 
 INTEGUMENTARY SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |

 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Fibrous Osteodystrophy               |             2           4                       4  4        4     4     4|     14  3.2|

 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hydrocephalus                        |                                                                      2   |      1  2.0|
      Necrosis, Focal                      |                                                                3         |      1  3.0|

 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inflammation, Granulomatous          |    1                                                     1     1         |      3  1.0|
      Inflammation, Suppurative            |                                                                          |      1  1.0|
      Alveolar Epithelium, Hyperplasia,    |                                                                          |            |
           Focal                           |                               1                                          |      2  1.5|
      Alveolar Epithelium, Interstitium,   |                                                                          |            |
           Mineralization                  |                                                                          |      1  2.0|
      Bronchus, Inflammation, Suppurative  |                                                                          |      1  3.0|
      Interstitium, Inflammation, Chronic  |                                                                          |      1  1.0|
      Interstitium, Mineralization         |                         3                       1  3  1           3     3|     10  2.2|

                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inflammation, Suppurative            |                   1                    2  2           1           3      |     11  1.5|

                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |

 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Eye                                     |                         +                                                |   1        |
      Cataract                             |                         3                                                |      1  3.0|

                                            __________________________________________________________________________|____________|
   Zymbal's Gland                          |                                           +                              |   1        |

 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inflammation, Focal, Suppurative     |                                                                          |      2  2.5|
      Nephropathy                          | 2  4  3  1  4  2  2  2  4  1  2  3  2  3  4  2  4  4  3  2  4  4  4  4  4|     50  3.0|
      Renal Tubule, Hyperplasia, Focal     |    4                                      4     2                 4      |      4  3.5|
      Renal Tubule, Hyperplasia, Oncocytic |                      1                                2                  |      2  1.5|

                                            __________________________________________________________________________|____________|
   Urethra                                 |                                                                          |   1        |

                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |

 __________________________________________________________________________________________________________________________________ 

  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
NTP Experiment-Test: 05187-09                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           METHYLEUGENOL                                       Date: 07/20/98  
Route: GAVAGE                                                                                                     Time: 09:02:53  
                                                                                                                                    

 _____________________________________________________________________________________________________________________              
                                           | 5| 2| 5| 6| 5| 6| 6| 6| 6| 5| 2| 1| 5| 5| 4| 6| 0| 5| 6| 6| 5| 5| 5| 5| 5|             
                             DAY ON TEST   | 4| 9| 0| 0| 5| 3| 3| 7| 0| 1| 1| 7| 1| 5| 9| 0| 1| 8| 1| 8| 5| 7| 8| 5| 2|             
                                           | 0| 9| 2| 8| 6| 1| 8| 4| 4| 3| 9| 7| 7| 7| 8| 4| 8| 9| 9| 0| 6| 0| 9| 3| 8|             

 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    300                                    | 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    MG/KG                                  | 1| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 8| 0| 1| 2| 3| 4| 5| 6| 7| 8|             

 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Periesophageal Tissue, Inflammation  |                                                 2                        |             

                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrosis                             |                                                                          |             
      Mineralization                       |                                                                3         |             
      Necrosis                             |                                                                          |             
      Parasite Metazoan                    |                                                                          |             

                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Parasite Metazoan                    |             X                                                            |             

                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Basophilic Focus                     |    X                                   X     X                           |             
      Clear Cell Focus                     | X                                            X                           |             
      Degeneration, Cystic, Focal          | 2     3  3  3  3  3  3  3  3        2  3     2     2  2  2  2  2  3  2  2|             
      Eosinophilic Focus                   | X  X  X  X  X  X        X  X  X     X  X     X     X  X  X  X  X  X  X  X|             
      Mixed Cell Focus                     |    X  X                                                                  |             
      Necrosis, Focal                      |                            2                                             |             
      Bile Duct, Cyst                      |                                                                      3   |             
      Bile Duct, Hyperplasia, Atypical,    |                                                                          |             
           Focal                           |                                                                          |             
      Bile Duct, Hyperplasia               |                   2  4     1        1  2     1  1     3  1  2  2     2   |             
      Centrilobular, Necrosis              |                                           3                              |             
      Hepatocyte, Hypertrophy              | 4  2  4  4  3  2  1     2  1  4  3     3     3  4     3     3        2  1|             
      Oval Cell, Hyperplasia               | 1  3  1     1           2  2  2  2  1  1  2  1  1        2           1  1|             

                                            __________________________________________________________________________|             
   Mesentery                               |                                     +                                    |             

                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Focal                   |                   1  3                                                   |             
      Acinus, Atrophy                      |    1                 1     1        1     1        2  1                  |             

                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Submandibular Gland, Cytoplasmic     |                                                                          |             
          Alteration                       | 2  2  2  2  2     2  2  2  2  2  2  2  2  2  2  2  2  2  2  2  2  2  2  2|             

                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Mineralization                       |                   2                                            3     3   |             
      Ulcer                                |                                                                          |             

                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |    1     2  2     1     2  3     3  3     2           2  1     2     3  3|             
      Inflammation, Focal, Suppurative     |                                                                          |             
      Mineralization                       | 3     3        3  3     3              4     4                 4     3  1|             
      Ulcer                                |                            2        2     3        2                     |             
      Neuroendocrine Cell, Hyperplasia     |                   3                                   1                  |             

 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             

 _____________________________________________________________________________________________________________________|             
NTP Experiment-Test: 05187-09                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           METHYLEUGENOL                                       Date: 07/20/98  
Route: GAVAGE                                                                                                     Time: 09:02:53  
                                                                                                                                    

 _____________________________________________________________________________________________________________________              
                                           | 5| 2| 5| 6| 5| 6| 6| 6| 6| 5| 2| 1| 5| 5| 4| 6| 0| 5| 6| 6| 5| 5| 5| 5| 5|             
                             DAY ON TEST   | 4| 9| 0| 0| 5| 3| 3| 7| 0| 1| 1| 7| 1| 5| 9| 0| 1| 8| 1| 8| 5| 7| 8| 5| 2|             
                                           | 0| 9| 2| 8| 6| 1| 8| 4| 4| 3| 9| 7| 7| 7| 8| 4| 8| 9| 9| 0| 6| 0| 9| 3| 8|             

 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    300                                    | 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    MG/KG                                  | 1| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 8| 0| 1| 2| 3| 4| 5| 6| 7| 8|             

 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |             
                                           |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Blood Vessel                            | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Mineralization                       | 4     4                                4     4                 4         |             
      Aorta, Hyperplasia                   |                                                                          |             
      Aorta, Mineralization                |                3  1     4                                            4   |             

                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Focal, Suppurative     |                                                                          |             
      Myocardium, Degeneration             | 2     2  2  1        1  1           2  2  1  2     1  1                  |             
      Myocardium, Mineralization           | 2              3  3                    2     3                 3         |             

 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Focal                   |                      1              1                                    |             
      Necrosis, Focal                      |                                           1                              |             
      Vacuolization Cytoplasmic, Focal     |                                              1                           |             

                                            __________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Focal                   |       3  4              1  1              1        1           4  4  1   |             

                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  M  +  +  +  +  +  +  +  +  M  +  I  +  +  +  +  +  +  +  +|             
      Hyperplasia, Focal                   |                      2                                                   |             
      Hyperplasia                          |                         3  2           4                             1   |             
      Bilateral, Hyperplasia               | 3     4           3                          3     2           4  3     3|             

                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                                                          |             
      Pars Distalis, Hyperplasia, Focal    |                                                             4            |             
      Pars Intermedia, Hyperplasia, Focal  |                                                    1                     |             

                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      C-Cell, Hyperplasia                  |       1                    2                       2  1  1  1           1|             
      Follicle, Cyst                       |                         3                                                |             
      Follicular Cell, Hyperplasia, Focal  |                                                                          |             

 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Peritoneum                              |                                        +                                 |             

 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Granuloma Sperm                      |                                                                          |             
      Serosa, Hyperplasia, Mesothelium     |                                                                          |             

                                            __________________________________________________________________________|             
   Preputial Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                     3                       1  2  3      |             
      Fibrosis                             |                         3                                                |             
      Hyperplasia, Focal                   |                      4     2                 2                          1|             
      Inflammation, Chronic                |       1     2                          1     3                           |             

                                            __________________________________________________________________________|             
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

 _____________________________________________________________________________________________________________________|             
NTP Experiment-Test: 05187-09                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           METHYLEUGENOL                                       Date: 07/20/98  
Route: GAVAGE                                                                                                     Time: 09:02:53  
                                                                                                                                    

 _____________________________________________________________________________________________________________________              
                                           | 5| 2| 5| 6| 5| 6| 6| 6| 6| 5| 2| 1| 5| 5| 4| 6| 0| 5| 6| 6| 5| 5| 5| 5| 5|             
                             DAY ON TEST   | 4| 9| 0| 0| 5| 3| 3| 7| 0| 1| 1| 7| 1| 5| 9| 0| 1| 8| 1| 8| 5| 7| 8| 5| 2|             
                                           | 0| 9| 2| 8| 6| 1| 8| 4| 4| 3| 9| 7| 7| 7| 8| 4| 8| 9| 9| 0| 6| 0| 9| 3| 8|             

 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    300                                    | 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    MG/KG                                  | 1| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 8| 0| 1| 2| 3| 4| 5| 6| 7| 8|             

 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
      Inflammation, Chronic                | 2     2  2                                                        2  1   |             

                                            __________________________________________________________________________|             
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Suppurative            |                                                                   2      |             
      Mineralization                       |                                                                      2   |             
      Serosa, Hyperplasia, Mesothelium     |                                                             1            |             

                                            __________________________________________________________________________|             
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |       4                                                                  |             
      Germinal Epithelium, Atrophy         |                                                                4         |             
      Interstitial Cell, Hyperplasia       |       3                                                                  |             
      Tunic, Hyperplasia, Mesothelium      |                                                             1            |             

 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |       1  2     1  1     1  1        1     1                 2  1         |             
      Necrosis                             |                                           2                              |             

                                            __________________________________________________________________________|             
   Lymph Node                              |                                                          +               |             
      Mediastinal, Erythrophagocytosis     |                                                          1               |             

                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrosis                             |                      2                                                  2|             
      Hematopoietic Cell Proliferation     |                            3                                             |             
      Lymphoid Follicle, Atrophy           |                                                                          |             

                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +|             

 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Dilatation                           |                                                                   2      |             
      Galactocele                          |       3                                                                  |             

                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Ulcer                                |                      2                                                   |             
      Pinna, Ulcer                         |    2                                                                     |             

 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrous Osteodystrophy               | 1     2        2        4              4     4                 3  2  4  3|             
      Cranium, Hyperostosis                |                                                                          |             

 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hydrocephalus                        |       1                                                                  |             

 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

 _____________________________________________________________________________________________________________________|             
NTP Experiment-Test: 05187-09                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           METHYLEUGENOL                                       Date: 07/20/98  
Route: GAVAGE                                                                                                     Time: 09:02:53  
                                                                                                                                    

 _____________________________________________________________________________________________________________________              
                                           | 5| 2| 5| 6| 5| 6| 6| 6| 6| 5| 2| 1| 5| 5| 4| 6| 0| 5| 6| 6| 5| 5| 5| 5| 5|             
                             DAY ON TEST   | 4| 9| 0| 0| 5| 3| 3| 7| 0| 1| 1| 7| 1| 5| 9| 0| 1| 8| 1| 8| 5| 7| 8| 5| 2|             
                                           | 0| 9| 2| 8| 6| 1| 8| 4| 4| 3| 9| 7| 7| 7| 8| 4| 8| 9| 9| 0| 6| 0| 9| 3| 8|             

 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    300                                    | 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    MG/KG                                  | 1| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 8| 0| 1| 2| 3| 4| 5| 6| 7| 8|             

 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
      Congestion                           |                                                 2                        |             
      Inflammation, Granulomatous          |                                                                         1|             
      Alveolar Epithelium, Hyperplasia,    |                                                                          |             
           Focal                           |                                                    1                     |             
      Interstitium, Inflammation, Chronic  |                                                          1               |             
      Interstitium, Mineralization         | 3     2        3  2     2              3     2                 3     3   |             

                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Suppurative            |                2  1                 1                          2     1   |             

                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation                         |                                                 2                        |             

 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Zymbal's Gland                          |                                     +                                    |             

 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hydronephrosis                       |                                                                          |             
      Inflammation, Focal, Suppurative     |                                                                          |             
      Nephropathy                          | 4     4  3  2  4  4  4  4  3  1     3  4  2  4     3  3  3  2  4  4  4  4|             
      Renal Tubule, Cyst                   |                                                                         3|             
      Renal Tubule, Hyperplasia, Focal     | 2           1                                                            |             
      Renal Tubule, Hyperplasia, Oncocytic |                                                                      4   |             

                                            __________________________________________________________________________|             
   Ureter                                  |                                                                          |             

                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Suppurative            |                                                                   1      |             
      Transitional Epithelium, Hyperplasia |                                                                2         |             

 _____________________________________________________________________________________________________________________|             
NTP Experiment-Test: 05187-09                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           METHYLEUGENOL                                       Date: 07/20/98  
Route: GAVAGE                                                                                                     Time: 09:02:53  
                                                                                                                                    

 __________________________________________________________________________________________________________________________________ 
                                           | 5| 5| 3| 5| 4| 6| 5| 5| 5| 5| 5| 6| 5| 6| 5| 6| 5| 6| 5| 5| 5| 5| 5| 4| 6|            |
                             DAY ON TEST   | 2| 2| 8| 3| 3| 2| 9| 9| 4| 8| 9| 3| 2| 5| 3| 3| 8| 8| 7| 7| 0| 3| 9| 9| 0|            |
                                           | 8| 6| 0| 3| 7| 7| 2| 2| 8| 2| 7| 3| 1| 3| 7| 4| 9| 4| 2| 2| 6| 3| 1| 5| 1|      T (*) |

 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|      A     |
    300                                    | 3| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 7|      L     |
    MG/KG                                  | 9| 1| 2| 4| 5| 6| 8| 9| 0| 2| 3| 5| 6| 7| 8| 9| 0| 1| 2| 3| 5| 6| 7| 9| 0|            |

 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Periesophageal Tissue, Inflammation  |                                                                          |      1  2.0|

                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Fibrosis                             |                                                                   3      |      1  3.0|
      Mineralization                       |    2     3                 2                                             |      4  2.5|
      Necrosis                             |                                                                   3      |      1  3.0|
      Parasite Metazoan                    |                                                                   X      |      1     |

                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Parasite Metazoan                    |                                                                          |      1     |

                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |

                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |

                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |

                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |

                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Basophilic Focus                     |       X     X           X                                                |      6     |
      Clear Cell Focus                     |                                                                      X   |      3     |
      Degeneration, Cystic, Focal          | 2  2  2  1  2  2  2  3  2  2  2  2  1  2  1     2           2  2  3  2  2|     41  2.2|
      Eosinophilic Focus                   |    X        X     X  X  X  X  X  X     X  X  X  X  X  X     X  X  X  X  X|     39     |
      Mixed Cell Focus                     |                                                                          |      2     |
      Necrosis, Focal                      |                                                             3            |      2  2.5|
      Bile Duct, Cyst                      |                                                                          |      1  3.0|
      Bile Duct, Hyperplasia, Atypical,    |                                                                          |            |
           Focal                           |                      2                                                   |      1  2.0|
      Bile Duct, Hyperplasia               |    2        2  1  1  1  1     1  1  2  1     1        3  2  3  2        1|     28  1.7|
      Centrilobular, Necrosis              |                                                                          |      1  3.0|
      Hepatocyte, Hypertrophy              |    3        2     2  3  2        2     2        1                        |     26  2.5|
      Oval Cell, Hyperplasia               |       1     2  1  2  2              2  2     2        1  3              1|     27  1.6|

                                            __________________________________________________________________________|____________|
   Mesentery                               |                                                                          |   1        |

                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Hyperplasia, Focal                   |                                                                          |      2  2.0|
      Acinus, Atrophy                      |                   1                                   1  2               |     10  1.2|

                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Submandibular Gland, Cytoplasmic     |                                                                          |            |
          Alteration                       | 2  2  2     2  2  2  2  2  2  2  2  2  2  2  2  2  2  2  2  2  2  2  2  2|     48  2.0|

                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Mineralization                       |    3                       2                                             |      5  2.6|
      Ulcer                                |                                     4                                    |      1  4.0|

                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Atrophy                              | 2           2  3  3  2  3     2        3     3     2  2  3  2  1     2   |     29  2.2|

 __________________________________________________________________________________________________________________________________ 

  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
NTP Experiment-Test: 05187-09                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           METHYLEUGENOL                                       Date: 07/20/98  
Route: GAVAGE                                                                                                     Time: 09:02:53  
                                                                                                                                    

 __________________________________________________________________________________________________________________________________ 
                                           | 5| 5| 3| 5| 4| 6| 5| 5| 5| 5| 5| 6| 5| 6| 5| 6| 5| 6| 5| 5| 5| 5| 5| 4| 6|            |
                             DAY ON TEST   | 2| 2| 8| 3| 3| 2| 9| 9| 4| 8| 9| 3| 2| 5| 3| 3| 8| 8| 7| 7| 0| 3| 9| 9| 0|            |
                                           | 8| 6| 0| 3| 7| 7| 2| 2| 8| 2| 7| 3| 1| 3| 7| 4| 9| 4| 2| 2| 6| 3| 1| 5| 1|      T (*) |

 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|      A     |
    300                                    | 3| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 7|      L     |
    MG/KG                                  | 9| 1| 2| 4| 5| 6| 8| 9| 0| 2| 3| 5| 6| 7| 8| 9| 0| 1| 2| 3| 5| 6| 7| 9| 0|            |

 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
                                           |                                                                          |            |
      Inflammation, Focal, Suppurative     |                                                          1               |      1  1.0|
      Mineralization                       |    4           2  3  2     2     3     2     1  2                 3      |     20  2.8|
      Ulcer                                |             2  2              2     2                                    |      8  2.1|
      Neuroendocrine Cell, Hyperplasia     | 2                             2        2  2              1              1|      8  1.8|

 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Blood Vessel                            | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Mineralization                       |    3     4                 3                                      1      |      9  3.4|
      Aorta, Hyperplasia                   |                                                 4                        |      1  4.0|
      Aorta, Mineralization                |                2  3  4           4     2     4                           |     10  3.1|

                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Inflammation, Focal, Suppurative     |                               2                                          |      1  2.0|
      Myocardium, Degeneration             | 1     1        2     2        1  2  1  2     2  2     1     1        1   |     25  1.5|
      Myocardium, Mineralization           |    2           1  3  1     2  1  1              1                 3      |     15  2.1|

 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia, Focal                   |                   1                                            1  1      |      5  1.0|
      Necrosis, Focal                      |                                                                          |      1  1.0|
      Vacuolization Cytoplasmic, Focal     |                                                                          |      1  1.0|

                                            __________________________________________________________________________|____________|
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia, Focal                   |                   1  3                                1  3        4      |     14  2.3|

                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |

                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  46        |
      Hyperplasia, Focal                   |                                                                          |      1  2.0|
      Hyperplasia                          |                      1              1        3                           |      7  2.1|
      Bilateral, Hyperplasia               |    4           3  3     3  3     3     3        3  3              4      |     18  3.2|

                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cyst                                 |                      3                                                   |      1  3.0|
      Pars Distalis, Hyperplasia, Focal    |                                                                          |      1  4.0|
      Pars Intermedia, Hyperplasia, Focal  |                                                                          |      1  1.0|

                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      C-Cell, Hyperplasia                  | 1           1           1           2              1  1  2  1  2        2|     17  1.4|
      Follicle, Cyst                       |                                                                          |      1  3.0|
      Follicular Cell, Hyperplasia, Focal  |                                                    1                     |      1  1.0|

 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Peritoneum                              |       +                                                                  |   2        |

 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |

 __________________________________________________________________________________________________________________________________ 

  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
NTP Experiment-Test: 05187-09                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           METHYLEUGENOL                                       Date: 07/20/98  
Route: GAVAGE                                                                                                     Time: 09:02:53  
                                                                                                                                    

 __________________________________________________________________________________________________________________________________ 
                                           | 5| 5| 3| 5| 4| 6| 5| 5| 5| 5| 5| 6| 5| 6| 5| 6| 5| 6| 5| 5| 5| 5| 5| 4| 6|            |
                             DAY ON TEST   | 2| 2| 8| 3| 3| 2| 9| 9| 4| 8| 9| 3| 2| 5| 3| 3| 8| 8| 7| 7| 0| 3| 9| 9| 0|            |
                                           | 8| 6| 0| 3| 7| 7| 2| 2| 8| 2| 7| 3| 1| 3| 7| 4| 9| 4| 2| 2| 6| 3| 1| 5| 1|      T (*) |

 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|      A     |
    300                                    | 3| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 7|      L     |
    MG/KG                                  | 9| 1| 2| 4| 5| 6| 8| 9| 0| 2| 3| 5| 6| 7| 8| 9| 0| 1| 2| 3| 5| 6| 7| 9| 0|            |

 __________________________________________________________________________________________________________________________________ 
 GENITAL SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Granuloma Sperm                      |                                        2                                 |      1  2.0|
      Serosa, Hyperplasia, Mesothelium     |             1                 4                                          |      2  2.5|

                                            __________________________________________________________________________|____________|
   Preputial Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cyst                                 |                                                                          |      4  2.3|
      Fibrosis                             |                                                                          |      1  3.0|
      Hyperplasia, Focal                   |                                              1                           |      5  2.0|
      Inflammation, Chronic                |                                                                          |      4  1.8|

                                            __________________________________________________________________________|____________|
   Prostate                                | +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Inflammation, Chronic                |                1        1     1                                         1|      9  1.4|

                                            __________________________________________________________________________|____________|
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inflammation, Suppurative            |                                  2                                      2|      3  2.0|
      Mineralization                       |    2     3                                                               |      3  2.3|
      Serosa, Hyperplasia, Mesothelium     |                                                                          |      1  1.0|

                                            __________________________________________________________________________|____________|
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Atrophy                              |                                                                          |      1  4.0|
      Germinal Epithelium, Atrophy         |                                                                          |      1  4.0|
      Interstitial Cell, Hyperplasia       |                                                                          |      1  3.0|
      Tunic, Hyperplasia, Mesothelium      |             1                 4                                          |      3  2.0|

 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia                          |    2  1     2     1  1           1        1                       1      |     18  1.2|
      Necrosis                             |                                                                          |      1  2.0|

                                            __________________________________________________________________________|____________|
   Lymph Node                              |                                                             +  +         |   3        |
      Mediastinal, Erythrophagocytosis     |                                                                          |      1  1.0|

                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M|  47        |

                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  M  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |

                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Fibrosis                             |                                              2     2                     |      4  2.0|
      Hematopoietic Cell Proliferation     | 3                                                           2     2      |      4  2.5|
      Lymphoid Follicle, Atrophy           |                      3                                                   |      1  3.0|

                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +  M  M  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  M  M  +  +  M|  43        |

 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  M  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  M  +  +  M  +  +  +|  46        |
      Dilatation                           |                                                                          |      1  2.0|
      Galactocele                          |                                                                          |      1  3.0|

 __________________________________________________________________________________________________________________________________ 

  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
NTP Experiment-Test: 05187-09                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           METHYLEUGENOL                                       Date: 07/20/98  
Route: GAVAGE                                                                                                     Time: 09:02:53  
                                                                                                                                    

 __________________________________________________________________________________________________________________________________ 
                                           | 5| 5| 3| 5| 4| 6| 5| 5| 5| 5| 5| 6| 5| 6| 5| 6| 5| 6| 5| 5| 5| 5| 5| 4| 6|            |
                             DAY ON TEST   | 2| 2| 8| 3| 3| 2| 9| 9| 4| 8| 9| 3| 2| 5| 3| 3| 8| 8| 7| 7| 0| 3| 9| 9| 0|            |
                                           | 8| 6| 0| 3| 7| 7| 2| 2| 8| 2| 7| 3| 1| 3| 7| 4| 9| 4| 2| 2| 6| 3| 1| 5| 1|      T (*) |

 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|      A     |
    300                                    | 3| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 7|      L     |
    MG/KG                                  | 9| 1| 2| 4| 5| 6| 8| 9| 0| 2| 3| 5| 6| 7| 8| 9| 0| 1| 2| 3| 5| 6| 7| 9| 0|            |

 __________________________________________________________________________________________________________________________________ 
 INTEGUMENTARY SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Ulcer                                |                                                                          |      1  2.0|
      Pinna, Ulcer                         |                                                                          |      1  2.0|

 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Fibrous Osteodystrophy               |    1     3     3  4  4     2     3     2     1  3                 1      |     21  2.7|
      Cranium, Hyperostosis                |                               4                                          |      1  4.0|

 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hydrocephalus                        |                                                                          |      1  1.0|

 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Congestion                           |                                                                          |      1  2.0|
      Inflammation, Granulomatous          |                                              2                           |      2  1.5|
      Alveolar Epithelium, Hyperplasia,    |                                                                          |            |
           Focal                           |                                                                          |      1  1.0|
      Interstitium, Inflammation, Chronic  |                                                                          |      1  1.0|
      Interstitium, Mineralization         |    3           1  1  1     3     3           1  2                 3      |     18  2.3|

                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inflammation, Suppurative            |                      2                 2        2                       1|      9  1.6|

                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Inflammation                         |                                                                          |      1  2.0|

 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Zymbal's Gland                          |                                                                          |   1        |

 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hydronephrosis                       |       3                                                                  |      1  3.0|
      Inflammation, Focal, Suppurative     |                               3                                          |      1  3.0|
      Nephropathy                          | 3  4  1  4  3  4  4  4  3  4  2  4  3  4  2  4  4  3  4  3  2  2  4  2  3|     47  3.3|
      Renal Tubule, Cyst                   |                   3                                                      |      2  3.0|
      Renal Tubule, Hyperplasia, Focal     |                                        3                                 |      3  2.0|
      Renal Tubule, Hyperplasia, Oncocytic |                                                                          |      1  4.0|

                                            __________________________________________________________________________|____________|
   Ureter                                  |       +                                                                  |   1        |

                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |

 __________________________________________________________________________________________________________________________________ 

  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
NTP Experiment-Test: 05187-09                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           METHYLEUGENOL                                       Date: 07/20/98  
Route: GAVAGE                                                                                                     Time: 09:02:53  
                                                                                                                                    

 __________________________________________________________________________________________________________________________________ 
                                           | 5| 5| 3| 5| 4| 6| 5| 5| 5| 5| 5| 6| 5| 6| 5| 6| 5| 6| 5| 5| 5| 5| 5| 4| 6|            |
                             DAY ON TEST   | 2| 2| 8| 3| 3| 2| 9| 9| 4| 8| 9| 3| 2| 5| 3| 3| 8| 8| 7| 7| 0| 3| 9| 9| 0|            |
                                           | 8| 6| 0| 3| 7| 7| 2| 2| 8| 2| 7| 3| 1| 3| 7| 4| 9| 4| 2| 2| 6| 3| 1| 5| 1|      T (*) |

 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|      A     |
    300                                    | 3| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 7|      L     |
    MG/KG                                  | 9| 1| 2| 4| 5| 6| 8| 9| 0| 2| 3| 5| 6| 7| 8| 9| 0| 1| 2| 3| 5| 6| 7| 9| 0|            |

 __________________________________________________________________________________________________________________________________ 
 URINARY SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
      Inflammation, Suppurative            |                                                                          |      1  1.0|
      Transitional Epithelium, Hyperplasia |                                                                          |      1  2.0|

 __________________________________________________________________________________________________________________________________ 

  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                             ------------------------------------------------------------                                           
                             ----------              END OF REPORT             ----------                                           
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