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TDMS Study 05188-06 Pathology Tables

NTP Experiment-Test: 05188-06  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                       SODIUM XYLENESULFONATE                                  Date: 04/04/96
Route: SKIN APPLICATION                                                                                           Time: 05:02:39




       Facility:  Battelle Columbus Laboratory

       Chemical CAS #:  1300-72-7

       Lock Date:  07/28/93

       Cage Range:  All

       Reasons For Removal:    All

       Removal Date Range:     All

       Treatment Groups:       Include All




































a  Number of animals examined microscopically at site and number of animals with lesion

                                                              Page   1


NTP Experiment-Test: 05188-06  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                       SODIUM XYLENESULFONATE                                  Date: 04/04/96  
Route: SKIN APPLICATION                                                                                           Time: 05:02:39  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE FEMALE                        0 MG/KG      182          364          727                                       
                                                                MG/KG        MG/KG        MG/KG                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
DISPOSITION SUMMARY                                                                                                                 

  Animals Initially in Study                          50           50           50           50                                     
  Early Deaths                                                                                                                      
    Natural Death                                      7           10            9            8                                     
    Moribund Sacrifice                                12            7            9            6                                     
  Survivors                                                                                                                         
    Terminal Sacrifice                                31           32           32           36                                     
  Missing                                                           1                                                               

  Animals Examined Microscopically                    50           49           50           50                                     
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Gallbladder                                        (49)         (17)         (18)         (50)                                   
      Leiomyosarcoma, Metastatic, Intestine Small,                                                                                  
           Jejunum                                                               1 (6%)                                             
   Intestine Large, Cecum                             (50)         (16)         (18)         (50)                                   
      Leiomyosarcoma                                                             1 (6%)                                             
   Intestine Small, Jejunum                           (49)         (16)         (18)         (50)                                   
      Fibrosarcoma, Metastatic, Skin                                                          1 (2%)                                
      Leiomyosarcoma                                                             1 (6%)                                             
   Liver                                              (50)         (49)         (50)         (50)                                   
      Hemangioma                                       2 (4%)                                                                       
      Hemangiosarcoma                                               1 (2%)       1 (2%)                                             
      Hepatocellular Carcinoma                         9 (18%)     10 (20%)      7 (14%)      8 (16%)                               
      Hepatocellular Carcinoma, Multiple               1 (2%)       3 (6%)                    2 (4%)                                
      Hepatocellular Adenoma                          10 (20%)      8 (16%)     14 (28%)     19 (38%)                               
      Hepatocellular Adenoma, Multiple                 8 (16%)      9 (18%)      4 (8%)       9 (18%)                               
      Hepatocholangiocarcinoma                         1 (2%)                    1 (2%)       2 (4%)                                
      Histiocytic Sarcoma                              3 (6%)       2 (4%)       2 (4%)       2 (4%)                                
      Leiomyosarcoma, Metastatic, Intestine Small,                                                                                  
           Jejunum                                                               1 (2%)                                             
   Mesentery                                          (7)          (6)          (5)          (12)                                   
      Fibrosarcoma, Metastatic, Skin                                                          1 (8%)                                
      Hemangioma                                                                              1 (8%)                                
      Hepatocholangiocarcinoma, Metastatic, Liver      1 (14%)                   1 (20%)      2 (17%)                               
      Histiocytic Sarcoma                              1 (14%)      1 (17%)      1 (20%)                                            
      Leiomyosarcoma, Metastatic, Intestine Small,                                                                                  
           Jejunum                                                               1 (20%)                                            
   Pancreas                                           (50)         (17)         (18)         (50)                                   
      Fibrosarcoma, Metastatic, Skin                                                          1 (2%)                                
      Hepatocholangiocarcinoma, Metastatic, Liver      1 (2%)                    1 (6%)                                             
      Histiocytic Sarcoma                              1 (2%)       1 (6%)       1 (6%)                                             
      Leiomyosarcoma, Metastatic, Intestine Small,                                                                                  
           Jejunum                                                               1 (6%)                                             

                                                             Page   2                                                               
NTP Experiment-Test: 05188-06  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                       SODIUM XYLENESULFONATE                                  Date: 04/04/96  
Route: SKIN APPLICATION                                                                                           Time: 05:02:39  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE FEMALE                        0 MG/KG      182          364          727                                       
                                                                MG/KG        MG/KG        MG/KG                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ALIMENTARY SYSTEM - cont                                                                                                            
   Salivary Glands                                    (50)         (17)         (18)         (50)                                   
   Stomach, Forestomach                               (50)         (17)         (18)         (50)                                   
      Squamous Cell Papilloma                                       2 (12%)                                                         
   Stomach, Glandular                                 (50)         (17)         (18)         (50)                                   
      Carcinoma                                                                  1 (6%)                                             
      Hepatocholangiocarcinoma, Metastatic, Liver                                1 (6%)                                             
      Histiocytic Sarcoma                              1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Blood Vessel                                       (50)         (17)         (18)         (50)                                   
      Aorta, Hepatocholangiocarcinoma, Metastatic,                                                                                  
           Liver                                                                 1 (6%)                                             
   Heart                                              (50)         (17)         (18)         (50)                                   
      Alveolar/Bronchiolar Carcinoma, Metastatic,                                                                                   
           Lung                                                                  1 (6%)                                             
      Histiocytic Sarcoma                              2 (4%)       1 (6%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Cortex                                     (50)         (17)         (18)         (50)                                   
      Hepatocholangiocarcinoma, Metastatic, Liver                                1 (6%)                                             
      Capsule, Adenoma                                 1 (2%)                                 1 (2%)                                
   Adrenal Medulla                                    (50)         (17)         (18)         (48)                                   
      Pheochromocytoma Benign                                                                 1 (2%)                                
   Islets, Pancreatic                                 (50)         (17)         (18)         (50)                                   
      Adenoma                                          1 (2%)                    1 (6%)                                             
      Carcinoma                                        1 (2%)                                                                       
   Pituitary Gland                                    (50)         (17)         (18)         (49)                                   
      Meningioma Malignant, Metastatic, Brain                       1 (6%)                                                          
      Pars Distalis, Adenoma                           7 (14%)      3 (18%)      1 (6%)       5 (10%)                               
      Pars Intermedia, Adenoma                         1 (2%)                                 2 (4%)                                
      Pars Intermedia, Carcinoma                                                              1 (2%)                                
   Thyroid Gland                                      (50)         (48)         (50)         (50)                                   
      Follicular Cell, Adenoma                         1 (2%)       5 (10%)      1 (2%)       6 (12%)                               
      Follicular Cell, Adenoma, Multiple               1 (2%)                                                                       
      Follicular Cell, Carcinoma                                                              1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    

                                                             Page   3                                                               
NTP Experiment-Test: 05188-06  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                       SODIUM XYLENESULFONATE                                  Date: 04/04/96  
Route: SKIN APPLICATION                                                                                           Time: 05:02:39  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE FEMALE                        0 MG/KG      182          364          727                                       
                                                                MG/KG        MG/KG        MG/KG                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Clitoral Gland                                     (49)         (15)         (15)         (46)                                   
      Hepatocholangiocarcinoma, Metastatic, Liver                                             1 (2%)                                
   Ovary                                              (50)         (17)         (18)         (49)                                   
      Cystadenoma                                                   1 (6%)                    1 (2%)                                
      Fibrosarcoma, Metastatic, Skin                                                          1 (2%)                                
      Hemangioma                                                                 1 (6%)                                             
      Hepatocholangiocarcinoma, Metastatic, Liver                                1 (6%)                                             
      Histiocytic Sarcoma                              1 (2%)       1 (6%)       1 (6%)       1 (2%)                                
      Teratoma Benign                                  1 (2%)                                                                       
   Uterus                                             (50)         (17)         (18)         (50)                                   
      Hemangiosarcoma                                                                         1 (2%)                                
      Histiocytic Sarcoma                                           2 (12%)                   1 (2%)                                
      Leiomyosarcoma, Metastatic, Intestine Small,                                                                                  
           Jejunum                                                               1 (6%)                                             
      Polyp Stromal                                    3 (6%)       1 (6%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (50)         (17)         (18)         (50)                                   
      Histiocytic Sarcoma                              1 (2%)       2 (12%)                                                         
   Lymph Node                                         (7)          (3)          (6)          (6)                                    
      Bronchial, Alveolar/Bronchiolar Carcinoma,                                                                                    
           Metastatic, Lung                                                      1 (17%)                                            
      Inguinal, Histiocytic Sarcoma                                              1 (17%)                                            
      Lumbar, Histiocytic Sarcoma                                   2 (67%)                   2 (33%)                               
      Mediastinal, Hepatocholangiocarcinoma,                                                                                        
          Metastatic, Liver                            1 (14%)                   1 (17%)      1 (17%)                               
      Mediastinal, Histiocytic Sarcoma                 1 (14%)      1 (33%)                   1 (17%)                               
      Pancreatic, Histiocytic Sarcoma                                            1 (17%)                                            
      Renal, Hepatocholangiocarcinoma, Metastatic,                                                                                  
           Liver                                                                              1 (17%)                               
      Renal, Histiocytic Sarcoma                                                 1 (17%)      1 (17%)                               
      Thoracic, Fibrosarcoma, Metastatic, Skin         1 (14%)                                                                      
   Lymph Node, Mandibular                             (49)         (15)         (15)         (48)                                   
      Carcinoma, Metastatic, Harderian Gland                        1 (7%)                                                          
      Histiocytic Sarcoma                              2 (4%)                                 1 (2%)                                
   Lymph Node, Mesenteric                             (48)         (17)         (17)         (50)                                   
      Fibrosarcoma, Metastatic, Skin                                                          1 (2%)                                
      Hepatocholangiocarcinoma, Metastatic, Liver                                1 (6%)       2 (4%)                                
      Histiocytic Sarcoma                              2 (4%)       2 (12%)      1 (6%)       2 (4%)                                
      Leiomyosarcoma, Metastatic, Intestine Small,                                                                                  
           Jejunum                                                               1 (6%)                                             
   Spleen                                             (50)         (17)         (18)         (50)                                   
      Hemangiosarcoma                                               1 (6%)                    2 (4%)                                
      Histiocytic Sarcoma                              3 (6%)                    1 (6%)       1 (2%)                                

                                                             Page   4                                                               
NTP Experiment-Test: 05188-06  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                       SODIUM XYLENESULFONATE                                  Date: 04/04/96  
Route: SKIN APPLICATION                                                                                           Time: 05:02:39  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE FEMALE                        0 MG/KG      182          364          727                                       
                                                                MG/KG        MG/KG        MG/KG                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
HEMATOPOIETIC SYSTEM - cont                                                                                                         
   Thymus                                             (38)         (16)         (16)         (44)                                   
      Alveolar/Bronchiolar Carcinoma, Metastatic,                                                                                   
           Lung                                                                  1 (6%)                                             
      Hepatocholangiocarcinoma, Metastatic, Liver                                1 (6%)       2 (5%)                                
      Histiocytic Sarcoma                              1 (3%)                                 1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Mammary Gland                                      (50)         (17)         (16)         (50)                                   
      Carcinoma                                                                               1 (2%)                                
   Skin                                               (50)         (49)         (50)         (50)                                   
      Subcutaneous Tissue, Fibrosarcoma                1 (2%)                                 1 (2%)                                
      Subcutaneous Tissue, Hemangiosarcoma                                                    1 (2%)                                
      Subcutaneous Tissue, Skin, Site of                                                                                            
          Application, Fibrosarcoma                                 1 (2%)       1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Bone                                               (50)         (17)         (18)         (50)                                   
      Osteosarcoma                                     1 (2%)                                                                       
   Skeletal Muscle                                                              (1)          (3)                                    
      Fibrosarcoma, Metastatic, Skin                                                          1 (33%)                               
      Hepatocholangiocarcinoma, Metastatic, Liver                                1 (100%)     2 (67%)                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (50)         (17)         (18)         (50)                                   
      Carcinoma, Metastatic, Harderian Gland                        1 (6%)                                                          
      Histiocytic Sarcoma                              1 (2%)                                                                       
      Meningioma Malignant                                          1 (6%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (50)         (18)         (18)         (50)                                   
      Alveolar/Bronchiolar Adenoma                     4 (8%)       1 (6%)       2 (11%)      6 (12%)                               
      Alveolar/Bronchiolar Carcinoma                   2 (4%)                    1 (6%)                                             
      Carcinoma, Metastatic, Harderian Gland           1 (2%)       2 (11%)                   1 (2%)                                
      Fibrosarcoma, Metastatic, Skin                   1 (2%)                                                                       
      Hepatocellular Carcinoma, Metastatic, Liver      2 (4%)       2 (11%)      1 (6%)       3 (6%)                                
      Hepatocholangiocarcinoma, Metastatic, Liver      1 (2%)                    1 (6%)       2 (4%)                                
      Histiocytic Sarcoma                              3 (6%)       1 (6%)                    2 (4%)                                
      Leiomyosarcoma, Metastatic, Intestine Small,                                                                                  
           Jejunum                                                               1 (6%)                                             

                                                             Page   5                                                               
NTP Experiment-Test: 05188-06  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                       SODIUM XYLENESULFONATE                                  Date: 04/04/96  
Route: SKIN APPLICATION                                                                                           Time: 05:02:39  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE FEMALE                        0 MG/KG      182          364          727                                       
                                                                MG/KG        MG/KG        MG/KG                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
RESPIRATORY SYSTEM - cont                                                                                                           
      Leiomyosarcoma, Metastatic, Intestine Large,                                                                                  
           Cecum                                                                 1 (6%)                                             
      Squamous Cell Carcinoma, Metastatic, Urinary                                                                                  
          Bladder                                                                             1 (2%)                                
      Mediastinum, Alveolar/Bronchiolar Carcinoma,                                                                                  
           Metastatic, Lung                                                      1 (6%)                                             
   Nose                                               (50)         (17)         (18)         (50)                                   
      Histiocytic Sarcoma                                                                     1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Eye                                                (1)          (2)                                                              
      Carcinoma, Metastatic, Harderian Gland                        1 (50%)                                                         
   Harderian Gland                                    (5)          (2)          (1)          (3)                                    
      Adenoma                                          2 (40%)                                1 (33%)                               
      Carcinoma                                        1 (20%)      2 (100%)     1 (100%)     2 (67%)                               
      Bilateral, Adenoma                               1 (20%)                                                                      
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (50)         (17)         (18)         (50)                                   
      Hepatocholangiocarcinoma, Metastatic, Liver                                             1 (2%)                                
      Histiocytic Sarcoma                              3 (6%)       2 (12%)                                                         
   Urinary Bladder                                    (50)         (17)         (18)         (50)                                   
      Squamous Cell Carcinoma                                                                 1 (2%)                                
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SYSTEMIC LESIONS                                                                                                                   

   Multiple Organs                                   *(50)        *(49)        *(50)        *(50)                                   
      Histiocytic Sarcoma                              3 (6%)       2 (4%)       2 (4%)       2 (4%)                                
      Lymphoma Malignant                               8 (16%)      3 (6%)       3 (6%)       5 (10%)                               
____________________________________________________________________________________________________________________________________

                                                                                                                                    
     *   Number of animals with any tissue examined microscopically                                                                 

                                                             Page   6                                                               
NTP Experiment-Test: 05188-06  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                       SODIUM XYLENESULFONATE                                  Date: 04/04/96  
Route: SKIN APPLICATION                                                                                           Time: 05:02:39  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE FEMALE                        0 MG/KG      182          364          727                                       
                                                                MG/KG        MG/KG        MG/KG                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
TUMOR SUMMARY                                                                                                                       
                                                                                                                                    
   Total Animals with Primary Neoplasms (b)            45          34          31          44                                       
     Total Primary Neoplasms                           71          54          44          82                                       
                                                                                                                                    
   Total Animals with Benign Neoplasms                 29          22          20          35                                       
     Total Benign Neoplasms                            43          30          24          52                                       
                                                                                                                                    
   Total Animals with Malignant Neoplasms              25          22          18          26                                       
     Total Malignant Neoplasms                         28          24          20          30                                       
                                                                                                                                    
   Total Animals with Metastatic Neoplasms              5           5           5           8                                       
     Total Metastatic Neoplasm                          9           8          24          25                                       
                                                                                                                                    
   Total Animals with Malignant Neoplasms                                                                                           
   Uncertain Primary Site                                                                                                           
                                                                                                                                    
   Total Animals with Neoplasms Uncertain-                                                                                          
   Benign or Malignant                                                                                                              
     Total Uncertain Neoplasms                                                                                                      
                                                                                                                                    

____________________________________________________________________________________________________________________________________
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Primary tumors: all tumors except metastatic tumors                                                                              

                                                             Page   7                                                               
NTP Experiment-Test: 05188-06  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                       SODIUM XYLENESULFONATE                                  Date: 04/04/96  
Route: SKIN APPLICATION                                                                                           Time: 05:02:39  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE MALE                          0 MG/KG      182          364          727                                       
                                                                MG/KG        MG/KG        MG/KG                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
DISPOSITION SUMMARY                                                                                                                 

  Animals Initially in Study                          50           50           50           50                                     
  Early Deaths                                                                                                                      
    Natural Death                                     11           10            3            9                                     
    Moribund Sacrifice                                 7            3            8            6                                     
  Survivors                                                                                                                         
    Terminal Sacrifice                                32           37           39           35                                     

  Animals Examined Microscopically                    50           50           50           50                                     
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Intestine Small, Jejunum                           (50)         (12)         (11)         (50)                                   
   Liver                                              (50)         (50)         (50)         (50)                                   
      Hemangioma                                       2 (4%)                                 1 (2%)                                
      Hemangiosarcoma                                  2 (4%)                    2 (4%)       1 (2%)                                
      Hemangiosarcoma, Multiple                        3 (6%)       3 (6%)       2 (4%)       1 (2%)                                
      Hemangiosarcoma, Metastatic, Spleen              1 (2%)       1 (2%)       1 (2%)       3 (6%)                                
      Hepatoblastoma                                                4 (8%)                    2 (4%)                                
      Hepatocellular Carcinoma                        21 (42%)     17 (34%)     12 (24%)     15 (30%)                               
      Hepatocellular Carcinoma, Multiple              14 (28%)     14 (28%)     10 (20%)     11 (22%)                               
      Hepatocellular Adenoma                          15 (30%)     21 (42%)     14 (28%)     13 (26%)                               
      Hepatocellular Adenoma, Multiple                22 (44%)     11 (22%)      7 (14%)     16 (32%)                               
      Hepatocholangiocarcinoma                         1 (2%)                                                                       
      Histiocytic Sarcoma                                           1 (2%)                                                          
      Osteosarcoma, Metastatic, Uncertain Primary                                                                                   
          Site                                                                   1 (2%)                                             
   Mesentery                                          (5)                                    (4)                                    
      Hemangiosarcoma, Metastatic, Spleen              1 (20%)                                                                      
      Hepatocholangiocarcinoma, Metastatic, Liver      1 (20%)                                                                      
      Liposarcoma, Multiple                                                                   1 (25%)                               
   Pancreas                                           (50)         (13)         (11)         (50)                                   
      Liposarcoma, Metastatic, Mesentery                                                      1 (2%)                                
   Salivary Glands                                    (50)         (13)         (11)         (50)                                   
   Stomach, Forestomach                               (50)         (13)         (11)         (50)                                   
      Squamous Cell Papilloma                          1 (2%)                                 1 (2%)                                
   Stomach, Glandular                                 (50)         (13)         (11)         (50)                                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Heart                                              (50)         (13)         (11)         (50)                                   
      Alveolar/Bronchiolar Carcinoma, Metastatic,                                                                                   
           Lung                                                     1 (8%)                                                          
      Hemangiosarcoma, Metastatic, Spleen                                                     1 (2%)                                

                                                             Page   8                                                               
NTP Experiment-Test: 05188-06  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                       SODIUM XYLENESULFONATE                                  Date: 04/04/96  
Route: SKIN APPLICATION                                                                                           Time: 05:02:39  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE MALE                          0 MG/KG      182          364          727                                       
                                                                MG/KG        MG/KG        MG/KG                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
CARDIOVASCULAR SYSTEM - cont                                                                                                        
      Hepatocholangiocarcinoma, Metastatic, Liver      1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Cortex                                     (50)         (12)         (11)         (50)                                   
   Adrenal Medulla                                    (50)         (12)         (11)         (50)                                   
      Pheochromocytoma Benign                                                                 2 (4%)                                
   Pituitary Gland                                    (49)         (12)         (10)         (50)                                   
      Pars Distalis, Adenoma                           1 (2%)                                                                       
   Thyroid Gland                                      (50)         (13)         (11)         (50)                                   
      Follicular Cell, Adenoma                         2 (4%)                    1 (9%)       1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Epididymis                                         (50)         (13)         (11)         (50)                                   
      Liposarcoma, Metastatic, Mesentery                                                      1 (2%)                                
   Prostate                                           (50)         (13)         (11)         (50)                                   
      Liposarcoma, Metastatic, Mesentery                                                      1 (2%)                                
   Seminal Vesicle                                    (50)         (13)         (11)         (50)                                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (50)         (13)         (11)         (50)                                   
      Hemangiosarcoma                                                            1 (9%)                                             
      Hemangiosarcoma, Metastatic, Spleen              1 (2%)                    1 (9%)                                             
   Lymph Node                                         (3)          (2)          (2)          (3)                                    
      Mediastinal, Alveolar/Bronchiolar Carcinoma,                                                                                  
           Metastatic, Lung                                         1 (50%)                                                         
      Mediastinal, Hemangiosarcoma, Metastatic,                                                                                     
           Liver                                       1 (33%)                                                                      
      Mediastinal, Hepatocholangiocarcinoma,                                                                                        
          Metastatic, Liver                            1 (33%)                                                                      
      Mediastinal, Histiocytic Sarcoma                              1 (50%)                                                         
   Lymph Node, Mandibular                             (43)         (7)          (8)          (42)                                   
   Lymph Node, Mesenteric                             (50)         (9)          (10)         (47)                                   
      Hemangioma                                       1 (2%)                                 1 (2%)                                
      Hemangiosarcoma, Metastatic, Spleen                                                     1 (2%)                                
   Spleen                                             (50)         (13)         (12)         (49)                                   
      Hemangiosarcoma                                  2 (4%)       1 (8%)       1 (8%)       3 (6%)                                

                                                             Page   9                                                               
NTP Experiment-Test: 05188-06  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                       SODIUM XYLENESULFONATE                                  Date: 04/04/96  
Route: SKIN APPLICATION                                                                                           Time: 05:02:39  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE MALE                          0 MG/KG      182          364          727                                       
                                                                MG/KG        MG/KG        MG/KG                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
HEMATOPOIETIC SYSTEM - cont                                                                                                         
      Hemangiosarcoma, Metastatic, Bone Marrow                                   1 (8%)                                             
      Liposarcoma, Metastatic, Mesentery                                                      1 (2%)                                
   Thymus                                             (37)         (11)         (6)          (34)                                   
      Alveolar/Bronchiolar Carcinoma, Metastatic,                                                                                   
           Lung                                                     1 (9%)                                                          
      Hepatocholangiocarcinoma, Metastatic, Liver      1 (3%)                                                                       
      Histiocytic Sarcoma                                           1 (9%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Skin                                               (50)         (50)         (50)         (50)                                   
      Subcutaneous Tissue, Fibrosarcoma                                                       1 (2%)                                
      Subcutaneous Tissue, Skin, Site of                                                                                            
          Application, Hemangioma                                                1 (2%)                                             
      Subcutaneous Tissue, Skin, Site of                                                                                            
          Application, Hemangiosarcoma                                           1 (2%)                                             
      Subcutaneous Tissue, Skin, Site of                                                                                            
          Application, Histiocytic Sarcoma                          2 (4%)                                                          
      Subcutaneous Tissue, Skin, Site of                                                                                            
          Application, Lymphoma Malignant                                        1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Skeletal Muscle                                                                           (3)                                    
      Hepatocellular Carcinoma, Metastatic, Liver                                             1 (33%)                               
      Liposarcoma, Metastatic, Mesentery                                                      1 (33%)                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (50)         (13)         (11)         (50)                                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (50)         (16)         (15)         (50)                                   
      Alveolar/Bronchiolar Adenoma                    12 (24%)      4 (25%)      2 (13%)      7 (14%)                               
      Alveolar/Bronchiolar Adenoma, Multiple           1 (2%)                                 2 (4%)                                
      Alveolar/Bronchiolar Carcinoma                   2 (4%)       1 (6%)       1 (7%)       1 (2%)                                
      Hemangiosarcoma, Metastatic, Spleen                                                     1 (2%)                                
      Hepatoblastoma, Metastatic, Liver                                                       2 (4%)                                
      Hepatocellular Carcinoma, Metastatic, Liver     12 (24%)      5 (31%)      7 (47%)     11 (22%)                               
      Hepatocholangiocarcinoma, Metastatic, Liver      1 (2%)                                                                       
      Histiocytic Sarcoma                                           1 (6%)                                                          
      Mediastinum, Alveolar/Bronchiolar Carcinoma,                                                                                  

                                                             Page  10                                                               
NTP Experiment-Test: 05188-06  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                       SODIUM XYLENESULFONATE                                  Date: 04/04/96  
Route: SKIN APPLICATION                                                                                           Time: 05:02:39  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE MALE                          0 MG/KG      182          364          727                                       
                                                                MG/KG        MG/KG        MG/KG                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
RESPIRATORY SYSTEM - cont                                                                                                           
           Metastatic, Lung                                         1 (6%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Harderian Gland                                    (2)                       (1)          (3)                                    
      Adenoma                                          1 (50%)                   1 (100%)     1 (33%)                               
      Carcinoma                                                                               1 (33%)                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (50)         (13)         (11)         (50)                                   
      Hepatocellular Carcinoma, Metastatic, Liver                   1 (8%)                    1 (2%)                                
      Renal Tubule, Adenoma                                                                   1 (2%)                                
      Renal Tubule, Carcinoma                                                                 1 (2%)                                
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SYSTEMIC LESIONS                                                                                                                   

   Multiple Organs                                   *(50)        *(50)        *(50)        *(50)                                   
      Histiocytic Sarcoma                                           2 (4%)                                                          
      Lymphoma Malignant                               5 (10%)                   4 (8%)       6 (12%)                               
____________________________________________________________________________________________________________________________________

                                                                                                                                    
     *   Number of animals with any tissue examined microscopically                                                                 

                                                             Page  11                                                               
NTP Experiment-Test: 05188-06  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                       SODIUM XYLENESULFONATE                                  Date: 04/04/96  
Route: SKIN APPLICATION                                                                                           Time: 05:02:39  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE MALE                          0 MG/KG      182          364          727                                       
                                                                MG/KG        MG/KG        MG/KG                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
TUMOR SUMMARY                                                                                                                       
                                                                                                                                    
   Total Animals with Primary Neoplasms (b)            49          41          36          47                                       
     Total Primary Neoplasms                          108          78          60          90                                       
                                                                                                                                    
   Total Animals with Benign Neoplasms                 43          33          24          37                                       
     Total Benign Neoplasms                            58          36          26          46                                       
                                                                                                                                    
   Total Animals with Malignant Neoplasms              39          33          28          33                                       
     Total Malignant Neoplasms                         50          42          34          44                                       
                                                                                                                                    
   Total Animals with Metastatic Neoplasms             15           6          10          16                                       
     Total Metastatic Neoplasm                         21          11          11          26                                       
                                                                                                                                    
   Total Animals with Malignant Neoplasms                                       1                                                   
   Uncertain Primary Site                                                                                                           
                                                                                                                                    
   Total Animals with Neoplasms Uncertain-                                                                                          
   Benign or Malignant                                                                                                              
     Total Uncertain Neoplasms                                                                                                      
                                                                                                                                    

____________________________________________________________________________________________________________________________________
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Primary tumors: all tumors except metastatic tumors                                                                              

                                                             Page  12                                                               
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