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TDMS Study 05188-06 Pathology Tables

                                              NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL
                                                       SODIUM XYLENESULFONATE


NTP Experiment-Test: 05188-06                                                                                     Report: PEIRPT09
Study Type: CHRONIC                                                                                               Date: 09/19/95
Route: SKIN APPLICATION                                                                                           Time: 14:07:09


                                                           CORE STUDY


       Facility:  Battelle Columbus Laboratory

       Chemical CAS #:  1300-72-7

       Lock Date:  07/28/93

       Cage Range:  All

       Reasons For Removal:    All

       Removal Date Range:     All

       Treatment Groups:       Include All

































                                                             Page   1
NTP Experiment-Test: 05188-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                       SODIUM XYLENESULFONATE                                  Date: 09/19/95  
Route: SKIN APPLICATION                                                                                           Time: 14:07:09  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 2| 7| 4| 7| 7| 7| 7| 6| 6| 7| 7| 7| 6| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7|             
                             DAY ON TEST   | 4| 4| 9| 4| 9| 4| 4| 4| 2| 8| 5| 4| 4| 4| 7| 7| 4| 4| 4| 4| 2| 4| 4| 4| 4|             
                                           | 1| 2| 2| 1| 5| 0| 2| 0| 6| 0| 9| 2| 2| 0| 0| 9| 2| 2| 2| 2| 1| 0| 0| 1| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    0 MG/KG                                | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Gallbladder                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation                         |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Lymphoid                |                         4                                                |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                                                          |             
      Eosinophilic Focus                   | X              X  X  X           X     X           X  X              X   |             
      Hematopoietic Cell Proliferation     |                         2                    2                           |             
      Inflammation, Chronic Active         |                   1     1        1     1              1  1  1  1     1  1|             
      Mixed Cell Focus                     |                                     X                 X                  |             
      Necrosis                             |          1                                                               |             
      Pigmentation, Hemosiderin            |                                                                          |             
      Bile Duct, Cyst                      | 1                                                                        |             
      Bile Duct, Hyperplasia               |                                                                      1   |             
                                            __________________________________________________________________________|             
   Mesentery                               |                               +        +     +                           |             
      Inflammation                         |                               3                                          |             
      Fat, Necrosis                        |                                        3                                 |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |    4                                1                                    |             
      Cytoplasmic Alteration               |                                                             1            |             
      Inflammation                         |                                                                          |             
      Duct, Cyst                           |    3                                                                     |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Focal                   |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood Vessel                            | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Mineralization                       |       1                                      1                           |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Accessory Adrenal Cortical Nodule    |                                                                          |             
      Capsule, Hyperplasia, Adenomatous    |                   4                                                      |             
                                            __________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page   2                                                               
NTP Experiment-Test: 05188-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                       SODIUM XYLENESULFONATE                                  Date: 09/19/95  
Route: SKIN APPLICATION                                                                                           Time: 14:07:09  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 2| 7| 4| 7| 7| 7| 7| 6| 6| 7| 7| 7| 6| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7|             
                             DAY ON TEST   | 4| 4| 9| 4| 9| 4| 4| 4| 2| 8| 5| 4| 4| 4| 7| 7| 4| 4| 4| 4| 2| 4| 4| 4| 4|             
                                           | 1| 2| 2| 1| 5| 0| 2| 0| 6| 0| 9| 2| 2| 0| 0| 9| 2| 2| 2| 2| 1| 0| 0| 1| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    0 MG/KG                                | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
      Hyperplasia                          |                      1                                      2            |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                        2           1  1     2            |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  M  M  M  +  +  +  M  +  +  M  +  M  +  M  +  +|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                                                          |             
      Pars Distalis, Hyperplasia           | 2  2        1     2  2  2           3  1  1  4           1     2     1   |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Follicle, Cyst                       |    3                                                                     |             
      Follicular Cell, Hyperplasia         | 1  1     1     1     1        1     1  3     1  1  2  1  1  2        2  2|             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Clitoral Gland                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 | 2                                3           4           1              2|             
      Hemorrhage                           |       4                                                                  |             
      Inflammation, Chronic Active         |                         4                                                |             
      Metaplasia                           |                                                                          |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Cystic                  | 4  2     2  2        2                    2        3                    4|             
      Pigmentation, Hemosiderin            |                                                                          |             
      Lymphatic, Angiectasis               |    3                                                                     |             
      Lymphatic, Cyst                      |                   4                                                      |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                         4  2  3              3                       2   |             
      Myelofibrosis                        |                                  2                                       |             
                                            __________________________________________________________________________|             
   Lymph Node                              |                         +                             +           +      |             
      Mediastinal, Hyperplasia, Lymphoid   |                         4                                                |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +|             
      Angiectasis                          |                               2                                          |             
      Hematopoietic Cell Proliferation     |                               2              2                           |             
      Hyperplasia, Lymphoid                |                                                                          |             
      Inflammation, Suppurative            |                            4                                             |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hematopoietic Cell Proliferation     |    1  2                 4  2  2              3                       2   |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  M  +  +  +  +  M  M  +  M  M  +  +  +  +  +  +  +  M  +  +  +|             
      Atrophy                              |                         3                 2  3                           |             
      Hyperplasia, Lymphoid                |                2                                                         |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   3                                                               
NTP Experiment-Test: 05188-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                       SODIUM XYLENESULFONATE                                  Date: 09/19/95  
Route: SKIN APPLICATION                                                                                           Time: 14:07:09  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 2| 7| 4| 7| 7| 7| 7| 6| 6| 7| 7| 7| 6| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7|             
                             DAY ON TEST   | 4| 4| 9| 4| 9| 4| 4| 4| 2| 8| 5| 4| 4| 4| 7| 7| 4| 4| 4| 4| 2| 4| 4| 4| 4|             
                                           | 1| 2| 2| 1| 5| 0| 2| 0| 6| 0| 9| 2| 2| 0| 0| 9| 2| 2| 2| 2| 1| 0| 0| 1| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    0 MG/KG                                | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |          2                                            3     2            |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Epidermis, Skin, Site of Application,|                                                                          |             
           Exudate                         |                                                                          |             
      Epidermis, Skin, Site of Application,|                                                                          |             
           Hyperplasia                     |                                                                      1   |             
      Skin, Site of Application,           |                                                                          |             
          Inflammation, Chronic            |                1                                                         |             
      Subcutaneous Tissue, Skin, Site of   |                                                                          |             
          Application, Inflammation,       |                                                                          |             
          Suppurative                      |                         4                                                |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Neuron, Necrosis                     |             2                                                            |             
                                            __________________________________________________________________________|             
   Peripheral Nerve                        |             +                                                            |             
                                            __________________________________________________________________________|             
   Spinal Cord                             |             +                                                            |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |                                                                          |             
      Inflammation                         |                                                                          |             
      Pigmentation, Hemosiderin            |                                                                          |             
      Alveolar Epithelium, Hyperplasia     |                                                 1                        |             
      Bronchiole, Hyperplasia              |                   1                                                      |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Suppurative            |                      1                                                   |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                                           +                              |             
      Cornea, Inflammation                 |                                           1                              |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                                        +  +           +        +         |             
      Hyperplasia                          |                                                                1         |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic Active         |                         4                                                |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   4                                                               
NTP Experiment-Test: 05188-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                       SODIUM XYLENESULFONATE                                  Date: 09/19/95  
Route: SKIN APPLICATION                                                                                           Time: 14:07:09  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 2| 7| 4| 7| 7| 7| 7| 6| 6| 7| 7| 7| 6| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7|             
                             DAY ON TEST   | 4| 4| 9| 4| 9| 4| 4| 4| 2| 8| 5| 4| 4| 4| 7| 7| 4| 4| 4| 4| 2| 4| 4| 4| 4|             
                                           | 1| 2| 2| 1| 5| 0| 2| 0| 6| 0| 9| 2| 2| 0| 0| 9| 2| 2| 2| 2| 1| 0| 0| 1| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    0 MG/KG                                | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
      Mineralization                       |                               2                                          |             
      Nephropathy                          | 1  1              1           2  1     2                 1     1     2   |             
      Pigmentation                         |       2                       3                                          |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page   5                                                               
NTP Experiment-Test: 05188-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                       SODIUM XYLENESULFONATE                                  Date: 09/19/95  
Route: SKIN APPLICATION                                                                                           Time: 14:07:09  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 7| 7| 7| 6| 7| 4| 7| 7| 7| 7| 6| 7| 7| 4| 6| 7| 7| 7| 7| 5| 7| 4| 7| 7|            |
                             DAY ON TEST   | 2| 4| 4| 4| 2| 4| 5| 4| 4| 3| 4| 5| 4| 4| 9| 9| 4| 4| 4| 4| 8| 0| 6| 2| 4|            |
                                           | 0| 2| 1| 2| 1| 0| 3| 2| 1| 4| 1| 9| 0| 2| 9| 2| 1| 0| 2| 0| 9| 1| 1| 2| 1|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|      A     |
    0 MG/KG                                | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Gallbladder                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inflammation                         |                                                             2            |      1  2.0|
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia, Lymphoid                |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Angiectasis                          |                      3                                                   |      1  3.0|
      Eosinophilic Focus                   |    X  X                                         X                    X  X|     14     |
      Hematopoietic Cell Proliferation     |                                                                          |      2  2.0|
      Inflammation, Chronic Active         |    1           1     1        1              1  1  1  1  1  1  2  1      |     22  1.0|
      Mixed Cell Focus                     |       X  X              X        X  X  X              X     X            |     10     |
      Necrosis                             |                                                                   2  1   |      3  1.3|
      Pigmentation, Hemosiderin            |                            3                                             |      1  3.0|
      Bile Duct, Cyst                      |                                  2                                       |      2  1.5|
      Bile Duct, Hyperplasia               |                1                 3                             2         |      4  1.8|
                                            __________________________________________________________________________|____________|
   Mesentery                               | +  +                                         +        +                  |   7        |
      Inflammation                         |                                                                          |      1  3.0|
      Fat, Necrosis                        |    2                                                  3                  |      3  2.7|
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Atrophy                              |                                  4                                       |      3  3.0|
      Cytoplasmic Alteration               |                                                                          |      1  1.0|
      Inflammation                         |                                                             2            |      1  2.0|
      Duct, Cyst                           |                                  4                                       |      2  3.5|
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Atrophy                              |                                                                      2   |      1  2.0|
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia, Focal                   |                                                                2         |      1  2.0|
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood Vessel                            | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Mineralization                       |             1              1              1                              |      5  1.0|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page   6                                                               
NTP Experiment-Test: 05188-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                       SODIUM XYLENESULFONATE                                  Date: 09/19/95  
Route: SKIN APPLICATION                                                                                           Time: 14:07:09  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 7| 7| 7| 6| 7| 4| 7| 7| 7| 7| 6| 7| 7| 4| 6| 7| 7| 7| 7| 5| 7| 4| 7| 7|            |
                             DAY ON TEST   | 2| 4| 4| 4| 2| 4| 5| 4| 4| 3| 4| 5| 4| 4| 9| 9| 4| 4| 4| 4| 8| 0| 6| 2| 4|            |
                                           | 0| 2| 1| 2| 1| 0| 3| 2| 1| 4| 1| 9| 0| 2| 9| 2| 1| 0| 2| 0| 9| 1| 1| 2| 1|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|      A     |
    0 MG/KG                                | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 __________________________________________________________________________________________________________________________________ 
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
                                           |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Accessory Adrenal Cortical Nodule    |                                                                      1   |      1  1.0|
      Capsule, Hyperplasia, Adenomatous    |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia                          |                                                                         3|      3  2.0|
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia                          |       1        1                                   1                     |      7  1.3|
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  M  M  +  +  M  +  +  +  M  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +|  38        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cyst                                 |                                                 2                        |      1  2.0|
      Pars Distalis, Hyperplasia           |    4  1  1     4     2        2              2  2     4  2  2           1|     25  2.0|
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Follicle, Cyst                       |                                                                          |      1  3.0|
      Follicular Cell, Hyperplasia         |    1     1     4     2  1              1           4  1  1              2|     26  1.5|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Clitoral Gland                          | +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cyst                                 |                         4        4     2        4                       2|     10  2.8|
      Hemorrhage                           |                                                                          |      1  4.0|
      Inflammation, Chronic Active         |                                                                          |      1  4.0|
      Metaplasia                           |                                                             3            |      1  3.0|
                                            __________________________________________________________________________|____________|
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia, Cystic                  | 3        3           4  2     2        2     2     1  2  2     3  3     2|     21  2.5|
      Pigmentation, Hemosiderin            |                                                       3                  |      1  3.0|
      Lymphatic, Angiectasis               |                                                                          |      1  3.0|
      Lymphatic, Cyst                      |                                                                          |      1  4.0|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia                          | 2                          2     3  3        2                 2     2   |     12  2.5|
      Myelofibrosis                        |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +           +                                +                       +   |   7        |
      Mediastinal, Hyperplasia, Lymphoid   |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +|  49        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page   7                                                               
NTP Experiment-Test: 05188-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                       SODIUM XYLENESULFONATE                                  Date: 09/19/95  
Route: SKIN APPLICATION                                                                                           Time: 14:07:09  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 7| 7| 7| 6| 7| 4| 7| 7| 7| 7| 6| 7| 7| 4| 6| 7| 7| 7| 7| 5| 7| 4| 7| 7|            |
                             DAY ON TEST   | 2| 4| 4| 4| 2| 4| 5| 4| 4| 3| 4| 5| 4| 4| 9| 9| 4| 4| 4| 4| 8| 0| 6| 2| 4|            |
                                           | 0| 2| 1| 2| 1| 0| 3| 2| 1| 4| 1| 9| 0| 2| 9| 2| 1| 0| 2| 0| 9| 1| 1| 2| 1|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|      A     |
    0 MG/KG                                | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Angiectasis                          |                                                                          |      1  2.0|
      Hematopoietic Cell Proliferation     |                                                                          |      2  2.0|
      Hyperplasia, Lymphoid                |                                                    4                     |      1  4.0|
      Inflammation, Suppurative            |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hematopoietic Cell Proliferation     | 4           4  2  3     3  3     3  3     4  3                 3     3   |     19  2.8|
                                            __________________________________________________________________________|____________|
   Thymus                                  | M  +  +  +  +  +  +  +  M  M  +  M  M  +  +  +  +  +  +  +  +  +  +  M  +|  38        |
      Atrophy                              |             2                                               4            |      5  2.8|
      Hyperplasia, Lymphoid                |                                                    4                     |      2  3.0|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia                          |                                                                3     3   |      5  2.6|
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Epidermis, Skin, Site of Application,|                                                                          |            |
           Exudate                         |                                                                         2|      1  2.0|
      Epidermis, Skin, Site of Application,|                                                                          |            |
           Hyperplasia                     |    1                          1                                         2|      4  1.3|
      Skin, Site of Application,           |                                                                          |            |
          Inflammation, Chronic            |    1                          1                 1                        |      4  1.0|
      Subcutaneous Tissue, Skin, Site of   |                                                                          |            |
          Application, Inflammation,       |                                                                          |            |
          Suppurative                      |                                                                          |      1  4.0|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Neuron, Necrosis                     |                                                             1            |      2  1.5|
                                            __________________________________________________________________________|____________|
   Peripheral Nerve                        |                                                                          |   1        |
                                            __________________________________________________________________________|____________|
   Spinal Cord                             |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hemorrhage                           |                                           2                              |      1  2.0|
      Inflammation                         |                                                             1            |      1  1.0|
      Pigmentation, Hemosiderin            |                                                                2         |      1  2.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page   8                                                               
NTP Experiment-Test: 05188-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                       SODIUM XYLENESULFONATE                                  Date: 09/19/95  
Route: SKIN APPLICATION                                                                                           Time: 14:07:09  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 7| 7| 7| 6| 7| 4| 7| 7| 7| 7| 6| 7| 7| 4| 6| 7| 7| 7| 7| 5| 7| 4| 7| 7|            |
                             DAY ON TEST   | 2| 4| 4| 4| 2| 4| 5| 4| 4| 3| 4| 5| 4| 4| 9| 9| 4| 4| 4| 4| 8| 0| 6| 2| 4|            |
                                           | 0| 2| 1| 2| 1| 0| 3| 2| 1| 4| 1| 9| 0| 2| 9| 2| 1| 0| 2| 0| 9| 1| 1| 2| 1|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|      A     |
    0 MG/KG                                | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 __________________________________________________________________________________________________________________________________ 
 RESPIRATORY SYSTEM - cont                 |                                                                          |            |
                                           |                                                                          |            |
      Alveolar Epithelium, Hyperplasia     |                                                                         2|      2  1.5|
      Bronchiole, Hyperplasia              |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inflammation, Suppurative            |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Eye                                     |                                                                          |   1        |
      Cornea, Inflammation                 |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Harderian Gland                         |                   +                                                      |   5        |
      Hyperplasia                          |                                                                          |      1  1.0|
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inflammation, Chronic Active         |                                                                          |      1  4.0|
      Mineralization                       |                                                                          |      1  2.0|
      Nephropathy                          |    1  1  1        1     1        2  1  1        1     1  1     1  1      |     22  1.2|
      Pigmentation                         |                                                                          |      2  2.5|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page   9                                                               
NTP Experiment-Test: 05188-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                       SODIUM XYLENESULFONATE                                  Date: 09/19/95  
Route: SKIN APPLICATION                                                                                           Time: 14:07:09  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 7| 7| 4| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 5| 0| 7| 7| 7| 7|             
                             DAY ON TEST   | 4| 7| 4| 4| 4| 4| 3| 4| 4| 4| 4| 4| 4| 4| 3| 4| 1| 4| 4| 3| 2| 4| 4| 4| 4|             
                                           | 0| 4| 0| 1| 6| 1| 6| 1| 0| 1| 0| 0| 0| 0| 5| 1| 8| 1| 0| 8| 4| 1| 2| 0| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    182                                    | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|             
    MG/KG                                  | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               |    +        +     M                       +              +  +            |             
      Inflammation                         |                                                                          |             
                                            __________________________________________________________________________|             
   Gallbladder                             |    +        +     +                       +              +  +            |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  |    +        +     +                       +              +  +            |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 |    +        +     +                       +              +  +            |             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  |    +        +     +                       +              +  +            |             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               |    +        +     +                       +              +  +            |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                |    +        +     +                       +              +  +            |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  |    +        +     +                       +              +  +            |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +|             
      Basophilic Focus                     |                                                                          |             
      Clear Cell Focus                     |                                                       X                  |             
      Eosinophilic Focus                   | X              X                 X                             X  X  X  X|             
      Hematopoietic Cell Proliferation     |                   2                                                      |             
      Inflammation, Chronic Active         | 1              1     1  1  1  1  1  1  1     1                    1  1  1|             
      Mixed Cell Focus                     |                                                          X               |             
      Necrosis                             | 2     1                                                     2            |             
      Bile Duct, Hyperplasia               |                                        1                             1   |             
                                            __________________________________________________________________________|             
   Mesentery                               |    +                                      +                              |             
      Fat, Necrosis                        |    3                                                                     |             
                                            __________________________________________________________________________|             
   Pancreas                                |    +        +     +                       +              +  +            |             
      Duct, Cyst                           |    4                                                                     |             
                                            __________________________________________________________________________|             
   Salivary Glands                         |    +        +     +                       +              +  +            |             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    |    +        +     +                       +              +  +            |             
      Hyperplasia, Focal                   |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      |    +        +     +                       +              +  +            |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood Vessel                            |    +        +     +                       +              +  +            |             
                                            __________________________________________________________________________|             
   Heart                                   |    +        +     +                       +              +  +            |             
      Degeneration                         |    1                                                        3            |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Cortex                          |    +        +     +                       +              +  +            |             
                                            __________________________________________________________________________|             
   Adrenal Medulla                         |    +        +     +                       +              +  +            |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      |    +        +     +                       +              +  +            |             
      Hyperplasia                          |                                                                          |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       |    +        +     M                       M              +  +            |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         |    +        +     +                       +              +  +            |             
      Pars Distalis, Hyperplasia           |                                           1              1               |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +|             
      Follicular Cell, Hyperplasia         |    4     1     2     1                    1  4                 1     1   |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  10                                                               
NTP Experiment-Test: 05188-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                       SODIUM XYLENESULFONATE                                  Date: 09/19/95  
Route: SKIN APPLICATION                                                                                           Time: 14:07:09  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 7| 7| 4| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 5| 0| 7| 7| 7| 7|             
                             DAY ON TEST   | 4| 7| 4| 4| 4| 4| 3| 4| 4| 4| 4| 4| 4| 4| 3| 4| 1| 4| 4| 3| 2| 4| 4| 4| 4|             
                                           | 0| 4| 0| 1| 6| 1| 6| 1| 0| 1| 0| 0| 0| 0| 5| 1| 8| 1| 0| 8| 4| 1| 2| 0| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    182                                    | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|             
    MG/KG                                  | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Clitoral Gland                          |    +        +     M                       +              +  +            |             
                                            __________________________________________________________________________|             
   Ovary                                   |    +        +     +                       +              +  +            |             
                                            __________________________________________________________________________|             
   Uterus                                  |    +        +     +                       +              +  +            |             
      Hyperplasia, Cystic                  |             3                                                            |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             |    +        +     +                       +              +  +            |             
      Hyperplasia                          |             2                                                            |             
                                            __________________________________________________________________________|             
   Lymph Node                              |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  |    M        +     +                       +              +  +            |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  |    +        +     +                       +              +  +            |             
      Hemorrhage                           |                                                             4            |             
                                            __________________________________________________________________________|             
   Spleen                                  |    +        +     +                       +              +  +            |             
      Hematopoietic Cell Proliferation     |             3     3                                         2            |             
                                            __________________________________________________________________________|             
   Thymus                                  |    +        +     +                       +              +  +            |             
      Atrophy                              |    2                                      4              2  4            |             
      Hyperplasia, Lymphoid                |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           |    +        +     +                       +              +  +            |             
      Hyperplasia                          |    1                                                                     |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +|             
      Epidermis, Skin, Site of Application,|                                                                          |             
           Exudate                         |             1     1                                                      |             
      Epidermis, Skin, Site of Application,|                                                                          |             
           Hyperplasia                     |             2                                                            |             
      Epidermis, Skin, Site of Application,|                                                                          |             
           Ulcer                           |             2                                                            |             
      Skin, Site of Application,           |                                                                          |             
          Inflammation, Chronic            |                                                       2                  |             
      Subcutaneous Tissue, Edema           |                                                                          |             
      Subcutaneous Tissue, Skin, Site of   |                                                                          |             
          Application, Inflammation,       |                                                                          |             
          Chronic Active                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    |    +        +     +                       +              +  +            |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   |    +        +     +                       +              +  +            |             
      Neuron, Necrosis                     |                                                                          |             
                                            __________________________________________________________________________|             
   Peripheral Nerve                        |                                                                          |             
                                            __________________________________________________________________________|             
   Spinal Cord                             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  11                                                               
NTP Experiment-Test: 05188-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                       SODIUM XYLENESULFONATE                                  Date: 09/19/95  
Route: SKIN APPLICATION                                                                                           Time: 14:07:09  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 7| 7| 4| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 5| 0| 7| 7| 7| 7|             
                             DAY ON TEST   | 4| 7| 4| 4| 4| 4| 3| 4| 4| 4| 4| 4| 4| 4| 3| 4| 1| 4| 4| 3| 2| 4| 4| 4| 4|             
                                           | 0| 4| 0| 1| 6| 1| 6| 1| 0| 1| 0| 0| 0| 0| 5| 1| 8| 1| 0| 8| 4| 1| 2| 0| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    182                                    | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|             
    MG/KG                                  | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    |    +        +     +                       +              +  +            |             
                                            __________________________________________________________________________|             
   Nose                                    |    +        +     +                       +              +  +            |             
                                            __________________________________________________________________________|             
   Trachea                                 |    +        +     +                       +              +  +            |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                   +                                         +            |             
      Degeneration                         |                                                             3            |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                   +                                                      |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  |    +        +     +                       +              +  +            |             
      Nephropathy                          |                                                                          |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         |    +        +     +                       +              +  +            |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  12                                                               
NTP Experiment-Test: 05188-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                       SODIUM XYLENESULFONATE                                  Date: 09/19/95  
Route: SKIN APPLICATION                                                                                           Time: 14:07:09  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 6| 6| 7| 7| 7| 7| 6| 7| 7| 3| 6| 7| 4| 6| 7| 7| 7| 7| 4| 7| 7| 7| 7| 7|            |
                             DAY ON TEST   | 4| 0| 6| 4| 4| 4| 1| 5| 4| 4| 3| 2| 4| 1| 4| 4| 4| 4| 1| 6| 3| 4| 4| 4| 4|            |
                                           | 0| 4| 6| 2| 0| 2| 8| 9| 1| 0| 7| 5| 1| 1| 2| 0| 0| 0| 2| 7| 1| 2| 2| 2| 1|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3|      A     |
    182                                    | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|      L     |
    MG/KG                                  | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               |    +  +           +  +        +  +     +  +           +  +  +            |  16        |
      Inflammation                         |                               2                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Gallbladder                             |    +  +           +  +        +  +     +  +           +  +  +            |  17        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  |    +  +           +  +        +  +     +  +           +  +  +            |  17        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 |    +  +           +  +        +  +     +  +           +  +  +            |  17        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  |    +  M           +  +        +  +     +  +           +  +  +            |  16        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               |    +  +           +  +        +  +     +  +           +  +  +            |  17        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                |    +  M           +  +        +  +     +  +           +  +  +            |  16        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  |    +  +           +  +        +  +     +  +           +  +  +            |  17        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Basophilic Focus                     |                                  X  X                 X                  |      3     |
      Clear Cell Focus                     |                                                                          |      1     |
      Eosinophilic Focus                   |       X        X                                X              X         |     11     |
      Hematopoietic Cell Proliferation     | 1                                                                        |      2  1.5|
      Inflammation, Chronic Active         |       1  1  1  1     1     2        2  1  1  1  1  1  1           1  1   |     28  1.1|
      Mixed Cell Focus                     |                            X                                X            |      3     |
      Necrosis                             |                                              1                           |      4  1.5|
      Bile Duct, Hyperplasia               |                                                                          |      2  1.0|
                                            __________________________________________________________________________|____________|
   Mesentery                               |                                  +                    +  +  +            |   6        |
      Fat, Necrosis                        |                                                       4                  |      2  3.5|
                                            __________________________________________________________________________|____________|
   Pancreas                                |    +  +           +  +        +  +     +  +           +  +  +            |  17        |
      Duct, Cyst                           |                                                          4               |      2  4.0|
                                            __________________________________________________________________________|____________|
   Salivary Glands                         |    +  +           +  +        +  +     +  +           +  +  +            |  17        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    |    +  +           +  +        +  +     +  +           +  +  +            |  17        |
      Hyperplasia, Focal                   |                                           2                              |      1  2.0|
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      |    +  +           +  +        +  +     +  +           +  +  +            |  17        |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood Vessel                            |    +  +           +  +        +  +     +  +           +  +  +            |  17        |
                                            __________________________________________________________________________|____________|
   Heart                                   |    +  +           +  +        +  +     +  +           +  +  +            |  17        |
      Degeneration                         |                                                                          |      2  2.0|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Cortex                          |    +  +           +  +        +  +     +  +           +  +  +            |  17        |
                                            __________________________________________________________________________|____________|
   Adrenal Medulla                         |    +  +           +  +        +  +     +  +           +  +  +            |  17        |
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      |    +  +           +  +        +  +     +  +           +  +  +            |  17        |
      Hyperplasia                          |                                                       2                  |      1  2.0|
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       |    +  +           +  M        M  +     +  +           +  +  M            |  12        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         |    +  +           +  +        +  +     +  +           +  +  +            |  17        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  13                                                               
NTP Experiment-Test: 05188-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                       SODIUM XYLENESULFONATE                                  Date: 09/19/95  
Route: SKIN APPLICATION                                                                                           Time: 14:07:09  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 6| 6| 7| 7| 7| 7| 6| 7| 7| 3| 6| 7| 4| 6| 7| 7| 7| 7| 4| 7| 7| 7| 7| 7|            |
                             DAY ON TEST   | 4| 0| 6| 4| 4| 4| 1| 5| 4| 4| 3| 2| 4| 1| 4| 4| 4| 4| 1| 6| 3| 4| 4| 4| 4|            |
                                           | 0| 4| 6| 2| 0| 2| 8| 9| 1| 0| 7| 5| 1| 1| 2| 0| 0| 0| 2| 7| 1| 2| 2| 2| 1|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3|      A     |
    182                                    | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|      L     |
    MG/KG                                  | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 __________________________________________________________________________________________________________________________________ 
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
                                           |                                                                          |            |
      Pars Distalis, Hyperplasia           |    4              1                       4              1               |      6  2.0|
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Follicular Cell, Hyperplasia         |    2  2  1  3           2  1              1  1                 1  1     1|     19  1.6|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Clitoral Gland                          |    +  +           M  +        +  +     +  +           +  +  +            |  15        |
                                            __________________________________________________________________________|____________|
   Ovary                                   |    +  +           +  +        +  +     +  +           +  +  +            |  17        |
                                            __________________________________________________________________________|____________|
   Uterus                                  |    +  +           +  +        +  +     +  +           +  +  +            |  17        |
      Hyperplasia, Cystic                  |                                                             1            |      2  2.0|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             |    +  +           +  +        +  +     +  +           +  +  +            |  17        |
      Hyperplasia                          |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Lymph Node                              |                   +                                      +  +            |   3        |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  |    +  +           +  +        +  +     +  +           +  +  M            |  15        |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  |    +  +           +  +        +  +     +  +           +  +  +            |  17        |
      Hemorrhage                           |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Spleen                                  |    +  +           +  +        +  +     +  +           +  +  +            |  17        |
      Hematopoietic Cell Proliferation     |                   4  3           4     2                 3               |      8  3.0|
                                            __________________________________________________________________________|____________|
   Thymus                                  |    +  +           +  +        +  +     +  M           +  +  +            |  16        |
      Atrophy                              |                   2  2                                   3               |      7  2.7|
      Hyperplasia, Lymphoid                |    3                                                                     |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           |    +  +           +  +        +  +     +  +           +  +  +            |  17        |
      Hyperplasia                          |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Epidermis, Skin, Site of Application,|                                                                          |            |
           Exudate                         |                               1                          1               |      4  1.0|
      Epidermis, Skin, Site of Application,|                                                                          |            |
           Hyperplasia                     |                                                                          |      1  2.0|
      Epidermis, Skin, Site of Application,|                                                                          |            |
           Ulcer                           |                                                                          |      1  2.0|
      Skin, Site of Application,           |                                                                          |            |
          Inflammation, Chronic            |                                                                          |      1  2.0|
      Subcutaneous Tissue, Edema           |                                                          1               |      1  1.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  14                                                               
NTP Experiment-Test: 05188-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                       SODIUM XYLENESULFONATE                                  Date: 09/19/95  
Route: SKIN APPLICATION                                                                                           Time: 14:07:09  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 6| 6| 7| 7| 7| 7| 6| 7| 7| 3| 6| 7| 4| 6| 7| 7| 7| 7| 4| 7| 7| 7| 7| 7|            |
                             DAY ON TEST   | 4| 0| 6| 4| 4| 4| 1| 5| 4| 4| 3| 2| 4| 1| 4| 4| 4| 4| 1| 6| 3| 4| 4| 4| 4|            |
                                           | 0| 4| 6| 2| 0| 2| 8| 9| 1| 0| 7| 5| 1| 1| 2| 0| 0| 0| 2| 7| 1| 2| 2| 2| 1|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3|      A     |
    182                                    | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|      L     |
    MG/KG                                  | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 __________________________________________________________________________________________________________________________________ 
 INTEGUMENTARY SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
      Subcutaneous Tissue, Skin, Site of   |                                                                          |            |
          Application, Inflammation,       |                                                                          |            |
          Chronic Active                   |                   1                                                      |      1  1.0|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    |    +  +           +  +        +  +     +  +           +  +  +            |  17        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   |    +  +           +  +        +  +     +  +           +  +  +            |  17        |
      Neuron, Necrosis                     |    2                                                                     |      1  2.0|
                                            __________________________________________________________________________|____________|
   Peripheral Nerve                        |                               +                                          |   1        |
                                            __________________________________________________________________________|____________|
   Spinal Cord                             |                               +                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    |    +  +           +  +        +  +  +  +  +           +  +  +            |  18        |
                                            __________________________________________________________________________|____________|
   Nose                                    |    +  +           +  +        +  +     +  +           +  +  +            |  17        |
                                            __________________________________________________________________________|____________|
   Trachea                                 |    +  +           +  +        +  +     +  +           +  +  +            |  17        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Eye                                     |                                                                          |   2        |
      Degeneration                         |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Harderian Gland                         |                      +                                                   |   2        |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  |    +  +           +  +        +  +     +  +           +  +  +            |  17        |
      Nephropathy                          |                                                       1                  |      1  1.0|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         |    +  +           +  +        +  +     +  +           +  +  +            |  17        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  15                                                               
NTP Experiment-Test: 05188-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                       SODIUM XYLENESULFONATE                                  Date: 09/19/95  
Route: SKIN APPLICATION                                                                                           Time: 14:07:09  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 6| 7| 7| 6| 6| 7| 7| 7| 6| 5| 7| 6| 7| 5| 7| 7| 7| 7| 7| 7| 7| 6| 5|             
                             DAY ON TEST   | 4| 5| 3| 4| 4| 7| 7| 4| 4| 3| 7| 8| 2| 8| 4| 6| 4| 4| 4| 4| 4| 4| 4| 0| 7|             
                                           | 2| 9| 6| 1| 1| 2| 4| 2| 0| 2| 9| 8| 8| 5| 0| 2| 0| 0| 1| 1| 2| 2| 0| 2| 5|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    364                                    | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
    MG/KG                                  | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               |    +  +        +  +        +  +  +  +  +     +                       +  +|             
                                            __________________________________________________________________________|             
   Gallbladder                             |    +  +        +  +        +  +  +  +  +     +                       +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  |    +  +        +  +        +  +  +  +  +     +                       +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 |    +  +        +  +        +  +  +  +  +     +                       +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  |    +  +        +  +        +  +  +  +  +     +                       +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               |    +  +        +  +        +  +  +  +  +     +                       +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                |    +  +        +  +        +  +  +  +  +     +                       +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  |    +  +        +  +        +  +  +  +  +     +                       +  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Basophilic Focus                     |                                                                          |             
      Eosinophilic Focus                   |       X              X                    X        X  X     X     X      |             
      Hematopoietic Cell Proliferation     |                                                          1               |             
      Inflammation, Chronic Active         |       1     1     1  1                    1  1     1     2  1  1  1     1|             
      Mixed Cell Focus                     |                                           X                              |             
      Necrosis                             |                1     1  1  2  2                          2     1        1|             
      Bile Duct, Hyperplasia               |    1  1                                                                  |             
      Serosa, Necrosis                     |    2                                                                     |             
                                            __________________________________________________________________________|             
   Mesentery                               |    +                       +     +  +                                +   |             
      Inflammation                         |    3                                                                     |             
                                            __________________________________________________________________________|             
   Pancreas                                |    +  +        +  +        +  +  +  +  +     +                       +  +|             
      Atrophy                              |       3                                                                  |             
      Duct, Cyst                           |       4                                                                  |             
                                            __________________________________________________________________________|             
   Salivary Glands                         |    +  +        +  +        +  +  +  +  +     +                       +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    |    +  +        +  +        +  +  +  +  +     +                       +  +|             
      Erosion                              |                            2                                             |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      |    +  +        +  +        +  +  +  +  +     +                       +  +|             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood Vessel                            |    +  +        +  +        +  +  +  +  +     +                       +  +|             
                                            __________________________________________________________________________|             
   Heart                                   |    +  +        +  +        +  +  +  +  +     +                       +  +|             
      Epicardium, Inflammation, Suppurative|                                  3                                       |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Cortex                          |    +  +        +  +        +  +  +  +  +     +                       +  +|             
      Hyperplasia                          |                                                                         2|             
                                            __________________________________________________________________________|             
   Adrenal Medulla                         |    +  +        +  +        +  +  +  +  +     +                       +  +|             
      Hyperplasia                          |       1                                                                  |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      |    +  +        +  +        +  +  +  +  +     +                       +  +|             
      Hyperplasia                          |    1                                                                    2|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       |    M  +        +  +        +  +  +  +  M     M                       M  +|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         |    +  +        +  +        +  +  +  +  +     +                       +  +|             
      Pars Distalis, Hyperplasia           |    3           1  2           2     2  2     1                          3|             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation                         |       3                                                                  |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  16                                                               
NTP Experiment-Test: 05188-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                       SODIUM XYLENESULFONATE                                  Date: 09/19/95  
Route: SKIN APPLICATION                                                                                           Time: 14:07:09  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 6| 7| 7| 6| 6| 7| 7| 7| 6| 5| 7| 6| 7| 5| 7| 7| 7| 7| 7| 7| 7| 6| 5|             
                             DAY ON TEST   | 4| 5| 3| 4| 4| 7| 7| 4| 4| 3| 7| 8| 2| 8| 4| 6| 4| 4| 4| 4| 4| 4| 4| 0| 7|             
                                           | 2| 9| 6| 1| 1| 2| 4| 2| 0| 2| 9| 8| 8| 5| 0| 2| 0| 0| 1| 1| 2| 2| 0| 2| 5|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    364                                    | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
    MG/KG                                  | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
      Follicular Cell, Hyperplasia         | 2           1     1        1  1     1           1  1  1        4  1      |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Clitoral Gland                          |    +  M        +  +        +  +  +  +  +     +                       +  M|             
                                            __________________________________________________________________________|             
   Ovary                                   |    +  +        +  +        +  +  +  +  +     +                       +  +|             
      Cyst                                 |                                              2                           |             
      Thrombosis                           |                            4                                             |             
                                            __________________________________________________________________________|             
   Uterus                                  |    +  +        +  +        +  +  +  +  +     +                       +  +|             
      Hemorrhage                           |                               4                                          |             
      Hyperplasia, Cystic                  |       3                       3     4                                    |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             |    +  +        +  +        +  +  +  +  +     +                       +  +|             
      Hyperplasia                          |                            3        3  3                             3   |             
                                            __________________________________________________________________________|             
   Lymph Node                              |                                  +  +  +                             +   |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  |    +  +        M  +        M  +  +  +  +     +                       +  +|             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  |    +  +        +  +        +  +  +  +  +     M                       +  +|             
                                            __________________________________________________________________________|             
   Spleen                                  |    +  +        +  +        +  +  +  +  +     +                       +  +|             
      Hematopoietic Cell Proliferation     |    3                       4  4        4     4                       2  4|             
                                            __________________________________________________________________________|             
   Thymus                                  |    +  +        +  +        M  +  +  M  +     +                       +  +|             
      Atrophy                              |    4           3                                                        4|             
      Cyst                                 |                                              4                           |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           |    +  +        M  +        +  +  +  +  +     +                       +  +|             
      Hyperplasia                          |    3  2                                                                  |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Epidermis, Skin, Site of Application,|                                                                          |             
           Exudate                         |                               1        2                                 |             
      Epidermis, Skin, Site of Application,|                                                                          |             
           Hyperplasia                     |                   1                    3                                 |             
      Epidermis, Skin, Site of Application,|                                                                          |             
           Ulcer                           |                                        2                                 |             
      Skin, Site of Application,           |                                                                          |             
          Inflammation, Chronic            |                                                                          |             
      Skin, Site of Application,           |                                                                          |             
          Parakeratosis                    |                                                                          |             
      Subcutaneous Tissue, Skin, Site of   |                                                                          |             
          Application, Inflammation,       |                                                                          |             
          Chronic Active                   | 1     1                                                                  |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  17                                                               
NTP Experiment-Test: 05188-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                       SODIUM XYLENESULFONATE                                  Date: 09/19/95  
Route: SKIN APPLICATION                                                                                           Time: 14:07:09  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 6| 7| 7| 6| 6| 7| 7| 7| 6| 5| 7| 6| 7| 5| 7| 7| 7| 7| 7| 7| 7| 6| 5|             
                             DAY ON TEST   | 4| 5| 3| 4| 4| 7| 7| 4| 4| 3| 7| 8| 2| 8| 4| 6| 4| 4| 4| 4| 4| 4| 4| 0| 7|             
                                           | 2| 9| 6| 1| 1| 2| 4| 2| 0| 2| 9| 8| 8| 5| 0| 2| 0| 0| 1| 1| 2| 2| 0| 2| 5|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    364                                    | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
    MG/KG                                  | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM - cont             |                                                                          |             
                                           |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    |    +  +        +  +        +  +  +  +  +     +                       +  +|             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |                                                                      +   |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   |    +  +        +  +        +  +  +  +  +     +                       +  +|             
      Inflammation                         |                                                                          |             
      Neuron, Necrosis                     |       1        2              2                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    |    +  +        +  +        +  +  +  +  +     +                       +  +|             
      Thrombosis                           |                               3                                          |             
                                            __________________________________________________________________________|             
   Nose                                    |    +  +        +  +        +  +  +  +  +     +                       +  +|             
                                            __________________________________________________________________________|             
   Trachea                                 |    +  +        +  +        +  +  +  +  +     +                       +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                   +                                                      |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  |    +  +        +  +        +  +  +  +  +     +                       +  +|             
      Infarct                              |                                                                          |             
      Nephropathy                          |    1  1        1                             1                       1   |             
      Artery, Inflammation, Chronic Active |                                                                          |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         |    +  +        +  +        +  +  +  +  +     +                       +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  18                                                               
NTP Experiment-Test: 05188-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                       SODIUM XYLENESULFONATE                                  Date: 09/19/95  
Route: SKIN APPLICATION                                                                                           Time: 14:07:09  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 6| 6| 7| 7| 7| 5| 7| 6| 7| 7| 6| 7| 7| 7| 7|            |
                             DAY ON TEST   | 4| 4| 4| 4| 4| 6| 4| 4| 4| 4| 2| 0| 4| 4| 4| 6| 4| 5| 4| 4| 4| 4| 4| 4| 4|            |
                                           | 2| 2| 1| 1| 2| 1| 1| 1| 1| 1| 2| 1| 2| 0| 2| 1| 0| 4| 0| 2| 2| 1| 0| 1| 1|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|      A     |
    364                                    | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      L     |
    MG/KG                                  | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               |                +              +  +           +     +        +            |  18        |
                                            __________________________________________________________________________|____________|
   Gallbladder                             |                +              +  +           +     +        +            |  18        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  |                +              +  +           +     +        +            |  18        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 |                +              +  +           +     +        +            |  18        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  |                +              +  +           +     +        +            |  18        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               |                +              +  +           +     +        +            |  18        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                |                +              +  +           +     +        +            |  18        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  |                +              +  +           +     +        +            |  18        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Basophilic Focus                     |                               X  X                                       |      2     |
      Eosinophilic Focus                   |                      X     X              X     X                        |     11     |
      Hematopoietic Cell Proliferation     |                                                                          |      1  1.0|
      Inflammation, Chronic Active         |    1        1     1     2     2     1     1  1  1  1  1  1               |     24  1.1|
      Mixed Cell Focus                     |                                                                          |      1     |
      Necrosis                             |                1                                                         |      9  1.3|
      Bile Duct, Hyperplasia               |                   1           1                                          |      4  1.0|
      Serosa, Necrosis                     |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Mesentery                               |                                                                          |   5        |
      Inflammation                         |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Pancreas                                |                +              +  +           +     +        +            |  18        |
      Atrophy                              |                                                                          |      1  3.0|
      Duct, Cyst                           |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Salivary Glands                         |                +              +  +           +     +        +            |  18        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    |                +              +  +           +     +        +            |  18        |
      Erosion                              |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      |                +              +  +           +     +        +            |  18        |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood Vessel                            |                +              +  +           +     +        +            |  18        |
                                            __________________________________________________________________________|____________|
   Heart                                   |                +              +  +           +     +        +            |  18        |
      Epicardium, Inflammation, Suppurative|                                                                          |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Cortex                          |                +              +  +           +     +        +            |  18        |
      Hyperplasia                          |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Adrenal Medulla                         |                +              +  +           +     +        +            |  18        |
      Hyperplasia                          |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      |                +              +  +           +     +        +            |  18        |
      Hyperplasia                          |                                                                          |      2  1.5|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  19                                                               
NTP Experiment-Test: 05188-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                       SODIUM XYLENESULFONATE                                  Date: 09/19/95  
Route: SKIN APPLICATION                                                                                           Time: 14:07:09  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 6| 6| 7| 7| 7| 5| 7| 6| 7| 7| 6| 7| 7| 7| 7|            |
                             DAY ON TEST   | 4| 4| 4| 4| 4| 6| 4| 4| 4| 4| 2| 0| 4| 4| 4| 6| 4| 5| 4| 4| 4| 4| 4| 4| 4|            |
                                           | 2| 2| 1| 1| 2| 1| 1| 1| 1| 1| 2| 1| 2| 0| 2| 1| 0| 4| 0| 2| 2| 1| 0| 1| 1|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|      A     |
    364                                    | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      L     |
    MG/KG                                  | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 __________________________________________________________________________________________________________________________________ 
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       |                +              M  +           M     M        +            |  11        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         |                +              +  +           +     +        +            |  18        |
      Pars Distalis, Hyperplasia           |                               1                    2        1            |     11  1.8|
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inflammation                         |                                                                          |      1  3.0|
      Follicular Cell, Hyperplasia         |       1                 2     1        3     1  3        2              2|     19  1.6|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Clitoral Gland                          |                M              +  +           +     +        +            |  15        |
                                            __________________________________________________________________________|____________|
   Ovary                                   |                +              +  +           +     +        +            |  18        |
      Cyst                                 |                                              4                           |      2  3.0|
      Thrombosis                           |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Uterus                                  |                +              +  +           +     +        +            |  18        |
      Hemorrhage                           |                                                                          |      1  4.0|
      Hyperplasia, Cystic                  |                               2                                          |      4  3.0|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             |                +              +  +           +     +        +            |  18        |
      Hyperplasia                          |                                                                          |      4  3.0|
                                            __________________________________________________________________________|____________|
   Lymph Node                              |                +              +                                          |   6        |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  |                M              +  +           +     +        +            |  15        |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  |                +              +  +           +     +        +            |  17        |
                                            __________________________________________________________________________|____________|
   Spleen                                  |                +              +  +           +     +        +            |  18        |
      Hematopoietic Cell Proliferation     |                4              1  2                 3        2            |     12  3.1|
                                            __________________________________________________________________________|____________|
   Thymus                                  |                +              +  +           +     +        +            |  16        |
      Atrophy                              |                                              3                           |      4  3.5|
      Cyst                                 |                                                                          |      1  4.0|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           |                +              +  +           M     +        +            |  16        |
      Hyperplasia                          |                                                    2                     |      3  2.3|
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Epidermis, Skin, Site of Application,|                                                                          |            |
           Exudate                         | 2                                1                                       |      4  1.5|
      Epidermis, Skin, Site of Application,|                                                                          |            |
           Hyperplasia                     |                                  1     1                                 |      4  1.5|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  20                                                               
NTP Experiment-Test: 05188-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                       SODIUM XYLENESULFONATE                                  Date: 09/19/95  
Route: SKIN APPLICATION                                                                                           Time: 14:07:09  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 6| 6| 7| 7| 7| 5| 7| 6| 7| 7| 6| 7| 7| 7| 7|            |
                             DAY ON TEST   | 4| 4| 4| 4| 4| 6| 4| 4| 4| 4| 2| 0| 4| 4| 4| 6| 4| 5| 4| 4| 4| 4| 4| 4| 4|            |
                                           | 2| 2| 1| 1| 2| 1| 1| 1| 1| 1| 2| 1| 2| 0| 2| 1| 0| 4| 0| 2| 2| 1| 0| 1| 1|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|      A     |
    364                                    | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      L     |
    MG/KG                                  | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 __________________________________________________________________________________________________________________________________ 
 INTEGUMENTARY SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
      Epidermis, Skin, Site of Application,|                                                                          |            |
           Ulcer                           |                                                                          |      1  2.0|
      Skin, Site of Application,           |                                                                          |            |
          Inflammation, Chronic            |                                                    1                     |      1  1.0|
      Skin, Site of Application,           |                                                                          |            |
          Parakeratosis                    | 1                                                                        |      1  1.0|
      Subcutaneous Tissue, Skin, Site of   |                                                                          |            |
          Application, Inflammation,       |                                                                          |            |
          Chronic Active                   |                                                                          |      2  1.0|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    |                +              +  +           +     +        +            |  18        |
                                            __________________________________________________________________________|____________|
   Skeletal Muscle                         |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   |                +              +  +           +     +        +            |  18        |
      Inflammation                         |                               2                                          |      1  2.0|
      Neuron, Necrosis                     |                                              2                           |      4  1.8|
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    |                +              +  +           +     +        +            |  18        |
      Thrombosis                           |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Nose                                    |                +              +  +           +     +        +            |  18        |
                                            __________________________________________________________________________|____________|
   Trachea                                 |                +              +  +           +     +        +            |  18        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Harderian Gland                         |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  |                +              +  +           +     +        +            |  18        |
      Infarct                              |                3                                                         |      1  3.0|
      Nephropathy                          |                                                             1            |      6  1.0|
      Artery, Inflammation, Chronic Active |                                                    2                     |      1  2.0|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         |                +              +  +           +     +        +            |  18        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  21                                                               
NTP Experiment-Test: 05188-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                       SODIUM XYLENESULFONATE                                  Date: 09/19/95  
Route: SKIN APPLICATION                                                                                           Time: 14:07:09  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 4| 7| 7| 7| 7| 7| 6| 7| 7| 7| 6| 6| 5| 7| 7| 7| 7| 7| 6| 7| 7| 7|             
                             DAY ON TEST   | 4| 4| 4| 0| 4| 1| 4| 4| 4| 1| 4| 4| 4| 2| 8| 3| 4| 4| 4| 4| 3| 9| 4| 4| 4|             
                                           | 0| 0| 1| 3| 2| 7| 0| 2| 1| 2| 1| 2| 1| 9| 6| 4| 1| 0| 1| 2| 0| 4| 2| 2| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    727                                    | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|             
    MG/KG                                  | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Gallbladder                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Basophilic Focus                     |                                                                          |             
      Eosinophilic Focus                   |                      X        X     X                             X  X   |             
      Hematopoietic Cell Proliferation     |                                                                          |             
      Infarct                              |                                                                          |             
      Inflammation, Chronic Active         | 1  1  1              1           1  2  1  1     1           1     1  1   |             
      Mixed Cell Focus                     |                               X                          X           X   |             
      Necrosis                             |                                                                          |             
      Pigmentation, Hemosiderin            |                                                                          |             
      Bile Duct, Hyperplasia               |                                     1                                    |             
                                            __________________________________________________________________________|             
   Mesentery                               | +              +           +              +  +        +                 +|             
      Fat, Necrosis                        | 2                                                     2                 4|             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                   4           3     4                                   4|             
      Cytoplasmic Alteration               |                1                                                         |             
      Necrosis                             |                                                                   2      |             
      Duct, Cyst                           |                   4           4                                         4|             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                                                                          |             
      Fibrosis                             |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Focal                   | 2                                                        2               |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood Vessel                            | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Aorta, Inflammation, Chronic Active  |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Mineralization                       |                                                                          |             
      Atrium, Thrombosis                   |                                                 4                        |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Degeneration                         |                                                                          |             
      Hyperplasia                          |                                                       2     1            |             
                                            __________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  22                                                               
NTP Experiment-Test: 05188-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                       SODIUM XYLENESULFONATE                                  Date: 09/19/95  
Route: SKIN APPLICATION                                                                                           Time: 14:07:09  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 4| 7| 7| 7| 7| 7| 6| 7| 7| 7| 6| 6| 5| 7| 7| 7| 7| 7| 6| 7| 7| 7|             
                             DAY ON TEST   | 4| 4| 4| 0| 4| 1| 4| 4| 4| 1| 4| 4| 4| 2| 8| 3| 4| 4| 4| 4| 3| 9| 4| 4| 4|             
                                           | 0| 0| 1| 3| 2| 7| 0| 2| 1| 2| 1| 2| 1| 9| 6| 4| 1| 0| 1| 2| 0| 4| 2| 2| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    727                                    | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|             
    MG/KG                                  | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
      Hyperplasia                          |                                                             3  1         |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |    2                          1     1                                    |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  M  M  +  +  M  +  +  M  +  M  +  M  M  +  +  M  M  +  +  +  M|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Pars Distalis, Hyperplasia           |                   2  3        1  1                 2     2  1  2  2     2|             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Follicular Cell, Hyperplasia         | 1  1  2        3  1              1  1           4     1  1        1  1  3|             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Clitoral Gland                          | +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |       2     4        2                             3                    3|             
                                            __________________________________________________________________________|             
   Oviduct                                 |                                                                          |             
      Inflammation, Chronic                |                                                                          |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Cystic                  | 2  4  1        3  4  1  1     1  1  2           2  2  1              4   |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |          3                                3  3  3              3        2|             
      Myelofibrosis                        |       2                       2  2                                       |             
                                            __________________________________________________________________________|             
   Lymph Node                              |          +                                +                              |             
      Mediastinal, Infiltration Cellular,  |                                                                          |             
           Histiocyte                      |                                           4                              |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                                                          |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                                                          |             
      Hematopoietic Cell Proliferation     |                3                                            3  3         |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  M  +  +  +  +  +  +  M  +  M  +  +  +  +  +  +  M  +  +  +|             
      Atrophy                              |          4                                                  3            |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                         1                 3     4                        |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Epidermis, Skin, Site of Application,|                                                                          |             
           Exudate                         |                                                                          |             
      Epidermis, Skin, Site of Application,|                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  23                                                               
NTP Experiment-Test: 05188-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                       SODIUM XYLENESULFONATE                                  Date: 09/19/95  
Route: SKIN APPLICATION                                                                                           Time: 14:07:09  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 4| 7| 7| 7| 7| 7| 6| 7| 7| 7| 6| 6| 5| 7| 7| 7| 7| 7| 6| 7| 7| 7|             
                             DAY ON TEST   | 4| 4| 4| 0| 4| 1| 4| 4| 4| 1| 4| 4| 4| 2| 8| 3| 4| 4| 4| 4| 3| 9| 4| 4| 4|             
                                           | 0| 0| 1| 3| 2| 7| 0| 2| 1| 2| 1| 2| 1| 9| 6| 4| 1| 0| 1| 2| 0| 4| 2| 2| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    727                                    | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|             
    MG/KG                                  | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
           Hyperplasia                     |          1                                            1     1            |             
      Epidermis, Skin, Site of Application,|                                                                          |             
           Ulcer                           |             3                                                            |             
      Skin, Site of Application,           |                                                                          |             
          Inflammation, Chronic            |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |                                           +  +                           |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Peripheral Nerve                        |                                                                          |             
                                            __________________________________________________________________________|             
   Spinal Cord                             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |                                                                          |             
      Hyperplasia, Lymphoid                |                                                                          |             
      Alveolar Epithelium, Hyperplasia     |                         2                                                |             
      Bronchiole, Hyperplasia              |                                                                          |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                   +                                                      |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hydronephrosis                       |                                                             2            |             
      Nephropathy                          | 1  1  1     1  1     1        1                                2  1  1   |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  24                                                               
NTP Experiment-Test: 05188-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                       SODIUM XYLENESULFONATE                                  Date: 09/19/95  
Route: SKIN APPLICATION                                                                                           Time: 14:07:09  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 0| 7| 7| 7| 7| 7|            |
                             DAY ON TEST   | 4| 4| 4| 4| 2| 7| 4| 4| 4| 4| 4| 4| 4| 4| 9| 3| 4| 4| 4| 7| 0| 4| 4| 4| 4|            |
                                           | 0| 2| 0| 2| 7| 5| 0| 2| 1| 1| 0| 1| 0| 2| 1| 8| 1| 0| 2| 2| 7| 1| 2| 2| 1|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4|      A     |
    727                                    | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|      L     |
    MG/KG                                  | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Gallbladder                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Basophilic Focus                     |                               X                                          |      1     |
      Eosinophilic Focus                   | X     X                                                     X     X     X|     10     |
      Hematopoietic Cell Proliferation     |                      1                                                   |      1  1.0|
      Infarct                              |                                                                4         |      1  4.0|
      Inflammation, Chronic Active         | 1  1     1     2           1  1  1     1                          2      |     21  1.1|
      Mixed Cell Focus                     |    X              X                                   X     X            |      7     |
      Necrosis                             |          1     1     4                                                   |      3  2.0|
      Pigmentation, Hemosiderin            |                                                 3                        |      1  3.0|
      Bile Duct, Hyperplasia               |                                                                   2      |      2  1.5|
                                            __________________________________________________________________________|____________|
   Mesentery                               |          +  +           +        +        +                              |  12        |
      Fat, Necrosis                        |          2              3        3        2                              |      7  2.6|
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Atrophy                              |             1     4                                                      |      6  3.3|
      Cytoplasmic Alteration               |                                                                          |      1  1.0|
      Necrosis                             |                                                                          |      1  2.0|
      Duct, Cyst                           |                   4                    3                                 |      5  3.8|
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Atrophy                              |                            3                                             |      1  3.0|
      Fibrosis                             |                                  2                                       |      1  2.0|
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia, Focal                   |                                                                2         |      3  2.0|
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood Vessel                            | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Aorta, Inflammation, Chronic Active  |                                                                      2   |      1  2.0|
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Mineralization                       |                                              1                           |      1  1.0|
      Atrium, Thrombosis                   |                                                                          |      1  4.0|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  25                                                               
NTP Experiment-Test: 05188-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                       SODIUM XYLENESULFONATE                                  Date: 09/19/95  
Route: SKIN APPLICATION                                                                                           Time: 14:07:09  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 0| 7| 7| 7| 7| 7|            |
                             DAY ON TEST   | 4| 4| 4| 4| 2| 7| 4| 4| 4| 4| 4| 4| 4| 4| 9| 3| 4| 4| 4| 7| 0| 4| 4| 4| 4|            |
                                           | 0| 2| 0| 2| 7| 5| 0| 2| 1| 1| 0| 1| 0| 2| 1| 8| 1| 0| 2| 2| 7| 1| 2| 2| 1|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4|      A     |
    727                                    | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|      L     |
    MG/KG                                  | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 __________________________________________________________________________________________________________________________________ 
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
                                           |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Degeneration                         |                               4                                          |      1  4.0|
      Hyperplasia                          |                                                                          |      2  1.5|
                                            __________________________________________________________________________|____________|
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Hyperplasia                          |                                        1                                 |      3  1.7|
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia                          | 1                                                                        |      4  1.3|
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  M  M  M  +  +  +  +  +|  36        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Pars Distalis, Hyperplasia           | 1  2  2  4  2        2  2     1  2  4     1     4  4           2  3  1   |     26  2.1|
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Follicular Cell, Hyperplasia         | 1  1  2  1     1  2     1  1     1  1     1           2                  |     25  1.4|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Clitoral Gland                          | +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  M  +  +  M  +  +  +  +  +  +|  46        |
                                            __________________________________________________________________________|____________|
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Cyst                                 |    3  2     2     3        2  3  4              3                        |     13  2.8|
                                            __________________________________________________________________________|____________|
   Oviduct                                 |                      +                                                   |   1        |
      Inflammation, Chronic                |                      3                                                   |      1  3.0|
                                            __________________________________________________________________________|____________|
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia, Cystic                  | 4  2           2              2  1     2                          3  4   |     22  2.2|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia                          |             3  2     3              3        3                           |     11  2.8|
      Myelofibrosis                        |                                                    2                     |      4  2.0|
                                            __________________________________________________________________________|____________|
   Lymph Node                              |             +                       +        +              +            |   6        |
      Mediastinal, Infiltration Cellular,  |                                                                          |            |
           Histiocyte                      |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +|  48        |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Angiectasis                          |                                                                   2  4   |      2  3.0|
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Angiectasis                          |                      3                                                   |      1  3.0|
      Hematopoietic Cell Proliferation     |             4  3     3              3                       3     3  2  3|     11  3.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  26                                                               
NTP Experiment-Test: 05188-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                       SODIUM XYLENESULFONATE                                  Date: 09/19/95  
Route: SKIN APPLICATION                                                                                           Time: 14:07:09  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 0| 7| 7| 7| 7| 7|            |
                             DAY ON TEST   | 4| 4| 4| 4| 2| 7| 4| 4| 4| 4| 4| 4| 4| 4| 9| 3| 4| 4| 4| 7| 0| 4| 4| 4| 4|            |
                                           | 0| 2| 0| 2| 7| 5| 0| 2| 1| 1| 0| 1| 0| 2| 1| 8| 1| 0| 2| 2| 7| 1| 2| 2| 1|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4|      A     |
    727                                    | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|      L     |
    MG/KG                                  | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +|  44        |
      Atrophy                              |                                     2           3                        |      4  3.0|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia                          |                                                       1     2     2      |      6  2.2|
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Epidermis, Skin, Site of Application,|                                                                          |            |
           Exudate                         |                                                             4            |      1  4.0|
      Epidermis, Skin, Site of Application,|                                                                          |            |
           Hyperplasia                     |                                                             3            |      4  1.5|
      Epidermis, Skin, Site of Application,|                                                                          |            |
           Ulcer                           |                                                                          |      1  3.0|
      Skin, Site of Application,           |                                                                          |            |
          Inflammation, Chronic            |                                                                         1|      1  1.0|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Skeletal Muscle                         |             +                                                            |   3        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Peripheral Nerve                        |                                                          +               |   1        |
                                            __________________________________________________________________________|____________|
   Spinal Cord                             |                                                          +               |   1        |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hemorrhage                           |                                                          4               |      1  4.0|
      Hyperplasia, Lymphoid                |                                           2                              |      1  2.0|
      Alveolar Epithelium, Hyperplasia     |       2                                                                  |      2  2.0|
      Bronchiole, Hyperplasia              |                            2                                             |      1  2.0|
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Harderian Gland                         |                                                    +        +            |   3        |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  27                                                               
NTP Experiment-Test: 05188-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                       SODIUM XYLENESULFONATE                                  Date: 09/19/95  
Route: SKIN APPLICATION                                                                                           Time: 14:07:09  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 0| 7| 7| 7| 7| 7|            |
                             DAY ON TEST   | 4| 4| 4| 4| 2| 7| 4| 4| 4| 4| 4| 4| 4| 4| 9| 3| 4| 4| 4| 7| 0| 4| 4| 4| 4|            |
                                           | 0| 2| 0| 2| 7| 5| 0| 2| 1| 1| 0| 1| 0| 2| 1| 8| 1| 0| 2| 2| 7| 1| 2| 2| 1|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4|      A     |
    727                                    | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|      L     |
    MG/KG                                  | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 __________________________________________________________________________________________________________________________________ 
 URINARY SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
      Hydronephrosis                       |                                                                          |      1  2.0|
      Nephropathy                          |          1              1  1     1              1  1                 1   |     17  1.1|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  28                                                               
NTP Experiment-Test: 05188-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                       SODIUM XYLENESULFONATE                                  Date: 09/19/95  
Route: SKIN APPLICATION                                                                                           Time: 14:07:09  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 7| 6| 6| 7| 7| 7| 6| 5| 6| 7| 6| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7|             
                             DAY ON TEST   | 3| 9| 3| 5| 4| 3| 0| 3| 9| 7| 8| 3| 8| 3| 3| 4| 3| 3| 3| 3| 9| 3| 3| 3| 0|             
                                           | 4| 1| 5| 1| 7| 5| 6| 4| 0| 5| 7| 5| 0| 3| 4| 6| 5| 5| 5| 3| 7| 3| 4| 5| 5|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    0 MG/KG                                | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Gallbladder                             | +  I  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Necrosis                             |                                              3                           |             
      Ulcer                                | 4                                                                        |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          | 2                                                                        |             
      Basophilic Focus                     |                                                                          |             
      Clear Cell Focus                     |                                                 X  X  X           X      |             
      Eosinophilic Focus                   |    X        X                 X  X  X                 X           X      |             
      Hematopoietic Cell Proliferation     |          2              1           1                                    |             
      Hemorrhage                           |                                                                         4|             
      Inflammation, Chronic Active         | 2  2     4  3  3  3  2  2  3  3  3  3  3  3  1  3  3  3  2     4  3  3  1|             
      Mixed Cell Focus                     |                                        X                                 |             
      Necrosis                             |             3                 3           2                              |             
      Thrombosis                           |                                                                          |             
      Bile Duct, Hyperplasia               | 3  3     3  2  2  4  2  3  3  4  2  2  2  3  1  2  3  3  4  2  4  2  2  1|             
      Kupffer Cell, Pigmentation           |                                                                          |             
                                            __________________________________________________________________________|             
   Mesentery                               |    +              +                          +                           |             
      Artery, Inflammation, Chronic Active |                   2                                                      |             
      Fat, Inflammation                    |                                                                          |             
      Vein, Thrombosis                     |                                              3                           |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                                        1                          2      |             
      Cytoplasmic Alteration               |                                                                      1   |             
      Necrosis                             |                                              2                           |             
      Artery, Inflammation, Chronic Active |                                                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                                                          |             
      Hyperplasia, Focal                   |       1                                                                  |             
      Ulcer                                |                   2                                                     4|             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood Vessel                            | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Aorta, Inflammation, Chronic Active  |                   2                                                      |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Degeneration                         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  29                                                               
NTP Experiment-Test: 05188-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                       SODIUM XYLENESULFONATE                                  Date: 09/19/95  
Route: SKIN APPLICATION                                                                                           Time: 14:07:09  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 7| 6| 6| 7| 7| 7| 6| 5| 6| 7| 6| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7|             
                             DAY ON TEST   | 3| 9| 3| 5| 4| 3| 0| 3| 9| 7| 8| 3| 8| 3| 3| 4| 3| 3| 3| 3| 9| 3| 3| 3| 0|             
                                           | 4| 1| 5| 1| 7| 5| 6| 4| 0| 5| 7| 5| 0| 3| 4| 6| 5| 5| 5| 3| 7| 3| 4| 5| 5|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    0 MG/KG                                | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |             
                                           |                                                                          |             
      Mineralization                       |                                                                         1|             
      Artery, Inflammation, Chronic Active |                   3                                                      |             
      Atrium, Thrombosis                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Accessory Adrenal Cortical Nodule    |                   1                                                      |             
      Hyperplasia                          |    1  1                                   1     1                 1      |             
                                            __________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                     2                    1               |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |       1                          1  1           2           1        1   |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                                                          |             
      Pars Distalis, Hyperplasia           |                                                                   2      |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Follicular Cell, Hyperplasia         |                1                 1                                       |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Granuloma Sperm                      |                                                                          |             
                                            __________________________________________________________________________|             
   Preputial Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic Active         |                                                                          |             
      Duct, Cyst                           |                   3                          3  3                        |             
                                            __________________________________________________________________________|             
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                  2                                       |             
      Hyperplasia                          | 3  3     3  2           2     3           2  2                          3|             
      Infiltration Cellular, Mast Cell     |                                                                         3|             
      Infiltration Cellular, Plasma Cell   |                                                                          |             
      Myelofibrosis                        |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node                              |    +     +                                                           +   |             
      Mediastinal, Hematopoietic Cell      |                                                                          |             
          Proliferation                    |          3                                                               |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  M  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  30                                                               
NTP Experiment-Test: 05188-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                       SODIUM XYLENESULFONATE                                  Date: 09/19/95  
Route: SKIN APPLICATION                                                                                           Time: 14:07:09  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 7| 6| 6| 7| 7| 7| 6| 5| 6| 7| 6| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7|             
                             DAY ON TEST   | 3| 9| 3| 5| 4| 3| 0| 3| 9| 7| 8| 3| 8| 3| 3| 4| 3| 3| 3| 3| 9| 3| 3| 3| 0|             
                                           | 4| 1| 5| 1| 7| 5| 6| 4| 0| 5| 7| 5| 0| 3| 4| 6| 5| 5| 5| 3| 7| 3| 4| 5| 5|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    0 MG/KG                                | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Angiectasis                          |                                                                         3|             
      Hematopoietic Cell Proliferation     |                      2                                                   |             
      Hyperplasia, Lymphoid                |                                                                          |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hematopoietic Cell Proliferation     | 2  3     3  2     3  1  3  3  2     3     3  3                          4|             
      Lymphoid Follicle, Hyperplasia       |                                                                          |             
                                            __________________________________________________________________________|             
   Thymus                                  | M  +  +  +  +  +  M  M  +  +  +  +  +  +  +  +  M  +  +  +  M  +  +  +  M|             
      Atrophy                              |          3  2           3     3     3        3           1               |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  M  +  M  +  M  M  M  +  M  M  M  +  M  +  M  M  +  +  +  M  M  +  M  M|             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Epidermis, Skin, Site of Application,|                                                                          |             
           Hyperplasia                     |                                                                          |             
      Subcutaneous Tissue, Edema           |                               3                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Mediastinum, Angiectasis             |                                                                         3|             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                                                                          |             
      Hyperplasia                          |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                     3  2                             1   |             
      Glomerulosclerosis                   |                   2        3                                             |             
      Infarct                              |                                                                          |             
      Nephropathy                          | 1     1     1  1     1  1        1  1  2  1  4  1  1  1  1  1  1  1  1  1|             
      Pigmentation, Hemosiderin            |                            1                                             |             
      Glomerulus, Infarct                  |          3                                                               |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  31                                                               
NTP Experiment-Test: 05188-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                       SODIUM XYLENESULFONATE                                  Date: 09/19/95  
Route: SKIN APPLICATION                                                                                           Time: 14:07:09  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 5| 4| 6| 7| 7| 7| 7| 7| 7| 7| 6|            |
                             DAY ON TEST   | 3| 6| 3| 3| 3| 3| 3| 3| 3| 3| 8| 0| 3| 3| 7| 9| 9| 3| 3| 3| 3| 3| 3| 3| 7|            |
                                           | 5| 4| 3| 4| 3| 4| 4| 3| 3| 3| 6| 2| 5| 3| 5| 4| 1| 3| 5| 4| 5| 5| 5| 5| 4|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      A     |
    0 MG/KG                                | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Gallbladder                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Necrosis                             |                                                                          |      1  3.0|
      Ulcer                                |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Angiectasis                          |                            2                                             |      2  2.0|
      Basophilic Focus                     |             X                                X                           |      2     |
      Clear Cell Focus                     |                                                                          |      4     |
      Eosinophilic Focus                   |          X  X           X     X        X  X                              |     13     |
      Hematopoietic Cell Proliferation     |                                                                          |      3  1.3|
      Hemorrhage                           |                                                                          |      1  4.0|
      Inflammation, Chronic Active         |       3  1  3  3  1  1  4  3  2  3  2  2  4  3  2  2  2  4  1  2  2  3  1|     46  2.5|
      Mixed Cell Focus                     |                               X        X                                 |      3     |
      Necrosis                             |    2        1           1              1     2                           |      8  1.9|
      Thrombosis                           |                                                                3         |      1  3.0|
      Bile Duct, Hyperplasia               |       4     1  2        3  3  2  2  2  2  3  3  2  2  2  3     3  1  3  1|     43  2.5|
      Kupffer Cell, Pigmentation           |                                                                   3      |      1  3.0|
                                            __________________________________________________________________________|____________|
   Mesentery                               |                               +                                +         |   5        |
      Artery, Inflammation, Chronic Active |                                                                          |      1  2.0|
      Fat, Inflammation                    |                                                                2         |      1  2.0|
      Vein, Thrombosis                     |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Atrophy                              |                                           2                              |      3  1.7|
      Cytoplasmic Alteration               |       1                                            1                 1   |      4  1.0|
      Necrosis                             |                                                                          |      1  2.0|
      Artery, Inflammation, Chronic Active |             4                                            3               |      2  3.5|
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cyst                                 |                                                    2                     |      1  2.0|
      Hyperplasia, Focal                   |                                                                          |      1  1.0|
      Ulcer                                |                                                                          |      2  3.0|
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  32                                                               
NTP Experiment-Test: 05188-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                       SODIUM XYLENESULFONATE                                  Date: 09/19/95  
Route: SKIN APPLICATION                                                                                           Time: 14:07:09  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 5| 4| 6| 7| 7| 7| 7| 7| 7| 7| 6|            |
                             DAY ON TEST   | 3| 6| 3| 3| 3| 3| 3| 3| 3| 3| 8| 0| 3| 3| 7| 9| 9| 3| 3| 3| 3| 3| 3| 3| 7|            |
                                           | 5| 4| 3| 4| 3| 4| 4| 3| 3| 3| 6| 2| 5| 3| 5| 4| 1| 3| 5| 4| 5| 5| 5| 5| 4|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      A     |
    0 MG/KG                                | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 __________________________________________________________________________________________________________________________________ 
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |            |
                                           |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood Vessel                            | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Aorta, Inflammation, Chronic Active  |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Degeneration                         |             1                                                     1      |      2  1.0|
      Mineralization                       |                                                                          |      1  1.0|
      Artery, Inflammation, Chronic Active |                                                                          |      1  3.0|
      Atrium, Thrombosis                   |                                                                         4|      1  4.0|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Accessory Adrenal Cortical Nodule    | 1                                                                        |      2  1.0|
      Hyperplasia                          |                      1  1  2           1     1                          4|     11  1.4|
                                            __________________________________________________________________________|____________|
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia                          |                                                                          |      2  1.5|
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia                          |                                        2           1        1            |      9  1.2|
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +  +  +  M  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  M  +|  46        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +|  49        |
      Cyst                                 |                                                          1           1   |      2  1.0|
      Pars Distalis, Hyperplasia           |                            2                                             |      2  2.0|
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Follicular Cell, Hyperplasia         | 1                                4  1           1                        |      6  1.5|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Granuloma Sperm                      | 4                    3                                                   |      2  3.5|
                                            __________________________________________________________________________|____________|
   Preputial Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inflammation, Chronic Active         |                                                                      4   |      1  4.0|
      Duct, Cyst                           |    3        4                             3                 3            |      7  3.1|
                                            __________________________________________________________________________|____________|
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  33                                                               
NTP Experiment-Test: 05188-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                       SODIUM XYLENESULFONATE                                  Date: 09/19/95  
Route: SKIN APPLICATION                                                                                           Time: 14:07:09  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 5| 4| 6| 7| 7| 7| 7| 7| 7| 7| 6|            |
                             DAY ON TEST   | 3| 6| 3| 3| 3| 3| 3| 3| 3| 3| 8| 0| 3| 3| 7| 9| 9| 3| 3| 3| 3| 3| 3| 3| 7|            |
                                           | 5| 4| 3| 4| 3| 4| 4| 3| 3| 3| 6| 2| 5| 3| 5| 4| 1| 3| 5| 4| 5| 5| 5| 5| 4|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      A     |
    0 MG/KG                                | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
      Angiectasis                          |                                                                          |      1  2.0|
      Hyperplasia                          |    2        2     2                       3     3     2           3     3|     17  2.5|
      Infiltration Cellular, Mast Cell     |                                                                          |      1  3.0|
      Infiltration Cellular, Plasma Cell   |                                                    2                     |      1  2.0|
      Myelofibrosis                        |                                                                2         |      1  2.0|
                                            __________________________________________________________________________|____________|
   Lymph Node                              |                                                                          |   3        |
      Mediastinal, Hematopoietic Cell      |                                                                          |            |
          Proliferation                    |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +  +  +  +  M  M  +  +  +  +  +  +  M  +  +  +  +  M  +  +  +  +  M|  43        |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Angiectasis                          |                                                                          |      1  3.0|
      Hematopoietic Cell Proliferation     |                                                                          |      1  2.0|
      Hyperplasia, Lymphoid                |                                                       2                  |      1  2.0|
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hematopoietic Cell Proliferation     |    2        2     2     2  2        1     3  1  3     2  2     2  3     3|     27  2.4|
      Lymphoid Follicle, Hyperplasia       |                                                       3                  |      1  3.0|
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +  +  +  M  +  M  +  +  +  M  M  +  +  M  +  +  +  +  M  +  +  M  +  +|  37        |
      Atrophy                              |                                                 3                       3|      9  2.7|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  M  M  M  +  M  M  M  M  +  M  +  M  +  M  +  M  M  M  +  +  M  M  M  M|  18        |
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Epidermis, Skin, Site of Application,|                                                                          |            |
           Hyperplasia                     |                         1                                                |      1  1.0|
      Subcutaneous Tissue, Edema           |                                                                          |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Mediastinum, Angiectasis             |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  34                                                               
NTP Experiment-Test: 05188-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                       SODIUM XYLENESULFONATE                                  Date: 09/19/95  
Route: SKIN APPLICATION                                                                                           Time: 14:07:09  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 5| 4| 6| 7| 7| 7| 7| 7| 7| 7| 6|            |
                             DAY ON TEST   | 3| 6| 3| 3| 3| 3| 3| 3| 3| 3| 8| 0| 3| 3| 7| 9| 9| 3| 3| 3| 3| 3| 3| 3| 7|            |
                                           | 5| 4| 3| 4| 3| 4| 4| 3| 3| 3| 6| 2| 5| 3| 5| 4| 1| 3| 5| 4| 5| 5| 5| 5| 4|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      A     |
    0 MG/KG                                | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 __________________________________________________________________________________________________________________________________ 
 SPECIAL SENSES SYSTEM - cont              |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Harderian Gland                         | +                             +                                          |   2        |
      Hyperplasia                          | 2                                                                        |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cyst                                 |                   3                       1                              |      5  2.0|
      Glomerulosclerosis                   |                                                                          |      2  2.5|
      Infarct                              |          2                                                               |      1  2.0|
      Nephropathy                          | 1  2  1  1  1  1  1  2  1  1     1  3  1  1     3  1  1  2  1  1  1  1  2|     43  1.3|
      Pigmentation, Hemosiderin            |                                                                          |      1  1.0|
      Glomerulus, Infarct                  |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  35                                                               
NTP Experiment-Test: 05188-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                       SODIUM XYLENESULFONATE                                  Date: 09/19/95  
Route: SKIN APPLICATION                                                                                           Time: 14:07:09  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 7| 7| 7| 7| 7| 7| 7| 3| 7| 7| 7| 7| 7| 6| 5| 7| 7| 7| 6| 7| 6| 7| 7|             
                             DAY ON TEST   | 7| 3| 3| 3| 3| 3| 3| 3| 0| 2| 3| 3| 3| 3| 3| 8| 4| 3| 3| 3| 5| 3| 8| 3| 3|             
                                           | 4| 5| 4| 4| 5| 3| 5| 5| 2| 2| 4| 5| 4| 4| 4| 7| 0| 4| 5| 5| 8| 4| 0| 5| 4|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    182                                    | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|             
    MG/KG                                  | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +                       +  +                 +  +           +     +      |             
                                            __________________________________________________________________________|             
   Gallbladder                             | M                       +  +                 +  +           +     +      |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +                       +  +                 +  +           +     +      |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +                       +  +                 +  +           +     +      |             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +                       +  +                 +  +           +     +      |             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +                       +  +                 +  +           +     +      |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +                       +  +                 +  +           +     +      |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +                       +  +                 +  +           +     +      |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                              2                           |             
      Basophilic Focus                     |             X                                         X  X        X      |             
      Clear Cell Focus                     |             X  X     X                                                   |             
      Eosinophilic Focus                   |          X  X     X  X                 X           X              X     X|             
      Inflammation, Chronic Active         |    4  4  4  3  3  3     3     4  1  3  3  3  3     3  3  3  4  1  3  3  1|             
      Mixed Cell Focus                     |                      X                                                   |             
      Necrosis                             |                                                                   2      |             
      Vacuolization Cytoplasmic            |             3                                                            |             
      Bile Duct, Hyperplasia               |    3  4  3  2  3  3     2     3     3  3  3  4     2  2  1  4  1  3  2   |             
                                            __________________________________________________________________________|             
   Pancreas                                | +                       +  +                 +  +           +     +      |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +                       +  +                 +  +           +     +      |             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +                       +  +                 +  +           +     +      |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +                       +  +                 +  +           +     +      |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood Vessel                            | +                       +  +                 +  +           +     +      |             
                                            __________________________________________________________________________|             
   Heart                                   | +                       +  +                 +  +           +     +      |             
      Degeneration                         |                                                             1            |             
      Atrium, Thrombosis                   | 4                                                                        |             
      Ventricle, Thrombosis                | 2                                                                        |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Cortex                          | +                       +  +                 +  +           +     +      |             
      Hyperplasia                          |                                                                   1      |             
                                            __________________________________________________________________________|             
   Adrenal Medulla                         | +                       +  +                 +  +           +     +      |             
      Hyperplasia                          | 2                                                           1            |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +                       +  +                 +  +           +     +      |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +                       M  +                 +  +           M     +      |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +                       +  +                 +  +           M     +      |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +                       +  +                 +  +           +     +      |             
      Follicular Cell, Hyperplasia         |                                                 1                        |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  36                                                               
NTP Experiment-Test: 05188-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                       SODIUM XYLENESULFONATE                                  Date: 09/19/95  
Route: SKIN APPLICATION                                                                                           Time: 14:07:09  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 7| 7| 7| 7| 7| 7| 7| 3| 7| 7| 7| 7| 7| 6| 5| 7| 7| 7| 6| 7| 6| 7| 7|             
                             DAY ON TEST   | 7| 3| 3| 3| 3| 3| 3| 3| 0| 2| 3| 3| 3| 3| 3| 8| 4| 3| 3| 3| 5| 3| 8| 3| 3|             
                                           | 4| 5| 4| 4| 5| 3| 5| 5| 2| 2| 4| 5| 4| 4| 4| 7| 0| 4| 5| 5| 8| 4| 0| 5| 4|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    182                                    | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|             
    MG/KG                                  | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              | +                       +  +                 +  +           +     +      |             
                                            __________________________________________________________________________|             
   Preputial Gland                         | +                       +  +                 +  +           +     +      |             
      Duct, Cyst                           |                                                             3            |             
                                            __________________________________________________________________________|             
   Prostate                                | +                       +  +                 +  +           +     +      |             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         | +                       +  +                 +  +           +     +      |             
                                            __________________________________________________________________________|             
   Testes                                  | +                       +  +                 +  +           +     +      |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +                       +  +                 +  +           +     +      |             
      Hyperplasia                          |                                                 2                        |             
                                            __________________________________________________________________________|             
   Lymph Node                              |                         +                                                |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | M                       M  +                 M  +           +     M      |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | M                       M  +                 +  +           +     +      |             
                                            __________________________________________________________________________|             
   Spleen                                  | +                       +  +                 +  +           +     +      |             
      Hematopoietic Cell Proliferation     | 4                       2                                   4     3      |             
                                            __________________________________________________________________________|             
   Thymus                                  | +                       +  +                 +  +           M     +      |             
      Atrophy                              | 3                                            3                           |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | M                       M  M                 M  M           M     M      |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Epidermis, Skin, Site of Application,|                                                                          |             
           Exudate                         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +                       +  +                 +  +           +     +      |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +                       +  +                 +  +           +     +      |             
      Neuron, Necrosis                     |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +           +           +  +                 +  +        +  +     +      |             
      Alveolar Epithelium, Hyperplasia     |                                              2                           |             
                                            __________________________________________________________________________|             
   Nose                                    | +                       +  +                 +  +           +     +      |             
                                            __________________________________________________________________________|             
   Trachea                                 | +                       +  +                 +  +           +     +      |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +                       +  +                 +  +           +     +      |             
      Glomerulosclerosis                   |                                              3                           |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  37                                                               
NTP Experiment-Test: 05188-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                       SODIUM XYLENESULFONATE                                  Date: 09/19/95  
Route: SKIN APPLICATION                                                                                           Time: 14:07:09  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 7| 7| 7| 7| 7| 7| 7| 3| 7| 7| 7| 7| 7| 6| 5| 7| 7| 7| 6| 7| 6| 7| 7|             
                             DAY ON TEST   | 7| 3| 3| 3| 3| 3| 3| 3| 0| 2| 3| 3| 3| 3| 3| 8| 4| 3| 3| 3| 5| 3| 8| 3| 3|             
                                           | 4| 5| 4| 4| 5| 3| 5| 5| 2| 2| 4| 5| 4| 4| 4| 7| 0| 4| 5| 5| 8| 4| 0| 5| 4|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    182                                    | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|             
    MG/KG                                  | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
      Nephropathy                          | 4                       1                    1  1           4     1      |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +                       +  +                 +  +           +     +      |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  38                                                               
NTP Experiment-Test: 05188-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                       SODIUM XYLENESULFONATE                                  Date: 09/19/95  
Route: SKIN APPLICATION                                                                                           Time: 14:07:09  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 6| 7| 6| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 5|            |
                             DAY ON TEST   | 3| 3| 1| 3| 3| 3| 3| 3| 3| 3| 3| 3| 2| 3| 3| 0| 3| 3| 3| 3| 3| 3| 5| 3| 8|            |
                                           | 5| 5| 0| 4| 9| 3| 3| 4| 5| 3| 4| 3| 0| 4| 3| 6| 4| 3| 4| 3| 4| 5| 9| 5| 8|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1|      A     |
    182                                    | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|      L     |
    MG/KG                                  | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               |       +     +                       +        +                    +     +|  13        |
                                            __________________________________________________________________________|____________|
   Gallbladder                             |       +     +                       +        +                    +     +|  12        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  |       +     +                       +        +                    +     +|  13        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 |       +     +                       +        +                    +     +|  13        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  |       +     +                       +        +                    +     +|  13        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               |       +     +                       +        M                    +     +|  12        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                |       +     +                       +        M                    +     +|  12        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  |       +     +                       +        +                    +     +|  13        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Angiectasis                          |    3                                                                     |      2  2.5|
      Basophilic Focus                     |    X                             X                                       |      6     |
      Clear Cell Focus                     |                                                                          |      3     |
      Eosinophilic Focus                   |    X                    X                                   X            |     11     |
      Inflammation, Chronic Active         | 4  3  3  4     2  3  4  3  4  1  4  3  2  2  2  3  2  2  2  3     3  1  1|     44  2.8|
      Mixed Cell Focus                     |    X     X                                                  X            |      4     |
      Necrosis                             |    1        4                       3        1                           |      5  2.2|
      Vacuolization Cytoplasmic            |                                           1                              |      2  2.0|
      Bile Duct, Hyperplasia               | 3  3  3  4  2  2  3  3  3  4     3  4  2  2  3  3  1  3  2  3     3     3|     41  2.8|
                                            __________________________________________________________________________|____________|
   Pancreas                                |       +     +                       +        +                    +     +|  13        |
                                            __________________________________________________________________________|____________|
   Salivary Glands                         |       +     +                       +        +                    +     +|  13        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    |       +     +                       +        +                    +     +|  13        |
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      |       +     +                       +        +                    +     +|  13        |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood Vessel                            |       +     +                       +        +                    +     +|  13        |
                                            __________________________________________________________________________|____________|
   Heart                                   |       +     +                       +        +                    +     +|  13        |
      Degeneration                         |                                                                          |      1  1.0|
      Atrium, Thrombosis                   |                                                                          |      1  4.0|
      Ventricle, Thrombosis                |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Cortex                          |       +     +                       +        M                    +     +|  12        |
      Hyperplasia                          |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Adrenal Medulla                         |       +     +                       +        M                    +     +|  12        |
      Hyperplasia                          |                                                                          |      2  1.5|
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      |       +     +                       +        +                    +     A|  12        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       |       M     +                       M        +                    +     +|   9        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         |       +     +                       +        +                    +     +|  12        |
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           |       +     +                       +        +                    +     +|  13        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  39                                                               
NTP Experiment-Test: 05188-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                       SODIUM XYLENESULFONATE                                  Date: 09/19/95  
Route: SKIN APPLICATION                                                                                           Time: 14:07:09  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 6| 7| 6| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 5|            |
                             DAY ON TEST   | 3| 3| 1| 3| 3| 3| 3| 3| 3| 3| 3| 3| 2| 3| 3| 0| 3| 3| 3| 3| 3| 3| 5| 3| 8|            |
                                           | 5| 5| 0| 4| 9| 3| 3| 4| 5| 3| 4| 3| 0| 4| 3| 6| 4| 3| 4| 3| 4| 5| 9| 5| 8|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1|      A     |
    182                                    | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|      L     |
    MG/KG                                  | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 __________________________________________________________________________________________________________________________________ 
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
                                           |                                                                          |            |
      Follicular Cell, Hyperplasia         |             2                                                            |      2  1.5|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Epididymis                              |       +     +                       +        +                    +     +|  13        |
                                            __________________________________________________________________________|____________|
   Preputial Gland                         |       +     +                       +        +                    +     +|  13        |
      Duct, Cyst                           |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Prostate                                |       +     +                       +        +                    +     +|  13        |
                                            __________________________________________________________________________|____________|
   Seminal Vesicle                         |       +     +                       +        +                    +     +|  13        |
                                            __________________________________________________________________________|____________|
   Testes                                  |       +     +                       +        +                    +     +|  13        |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             |       +     +                       +        +                    +     +|  13        |
      Hyperplasia                          |                                     3        3                           |      3  2.7|
                                            __________________________________________________________________________|____________|
   Lymph Node                              |       +                                                                  |   2        |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  |       M     +                       +        +                    +     M|   7        |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  |       +     +                       M        +                    +     M|   9        |
                                            __________________________________________________________________________|____________|
   Spleen                                  |       +     +                       +        +                    +     +|  13        |
      Hematopoietic Cell Proliferation     |       3     4                       3        4                           |      8  3.4|
                                            __________________________________________________________________________|____________|
   Thymus                                  |       +     +                       +        +                    M     +|  11        |
      Atrophy                              |             4                       3        2                           |      5  3.0|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           |       M     M                       +        M                    M     +|   2        |
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Epidermis, Skin, Site of Application,|                                                                          |            |
           Exudate                         |                                                                   1      |      1  1.0|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    |       +     +                       +        +                    +     +|  13        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   |       +     +                       +        +                    +     +|  13        |
      Neuron, Necrosis                     |                                                                         1|      1  1.0|
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    |       +     +                       +  +     +                    +     +|  16        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  40                                                               
NTP Experiment-Test: 05188-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                       SODIUM XYLENESULFONATE                                  Date: 09/19/95  
Route: SKIN APPLICATION                                                                                           Time: 14:07:09  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 6| 7| 6| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 5|            |
                             DAY ON TEST   | 3| 3| 1| 3| 3| 3| 3| 3| 3| 3| 3| 3| 2| 3| 3| 0| 3| 3| 3| 3| 3| 3| 5| 3| 8|            |
                                           | 5| 5| 0| 4| 9| 3| 3| 4| 5| 3| 4| 3| 0| 4| 3| 6| 4| 3| 4| 3| 4| 5| 9| 5| 8|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1|      A     |
    182                                    | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|      L     |
    MG/KG                                  | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 __________________________________________________________________________________________________________________________________ 
 RESPIRATORY SYSTEM - cont                 |                                                                          |            |
                                           |                                                                          |            |
      Alveolar Epithelium, Hyperplasia     |             2                                                            |      2  2.0|
                                            __________________________________________________________________________|____________|
   Nose                                    |       +     +                       +        +                    +     +|  13        |
                                            __________________________________________________________________________|____________|
   Trachea                                 |       +     +                       +        +                    +     +|  13        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  |       +     +                       +        +                    +     +|  13        |
      Glomerulosclerosis                   |                                                                          |      1  3.0|
      Nephropathy                          |             2                       1                             1     1|     10  1.7|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         |       +     +                       +        +                    +     +|  13        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  41                                                               
NTP Experiment-Test: 05188-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                       SODIUM XYLENESULFONATE                                  Date: 09/19/95  
Route: SKIN APPLICATION                                                                                           Time: 14:07:09  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 5| 7| 7| 5| 7| 7| 5| 6| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 6| 7| 7| 7|             
                             DAY ON TEST   | 3| 8| 4| 3| 3| 6| 3| 3| 7| 4| 3| 3| 3| 1| 3| 3| 3| 8| 3| 3| 3| 3| 3| 3| 3|             
                                           | 5| 6| 8| 5| 3| 1| 4| 4| 2| 4| 4| 5| 5| 8| 3| 3| 5| 7| 5| 3| 5| 6| 4| 3| 4|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    364                                    | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
    MG/KG                                  | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               |    +  +        +        +  +           +           +           +         |             
                                            __________________________________________________________________________|             
   Gallbladder                             |    +  +        +        +  +           +           +           +         |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  |    +  +        +        +  +           +           +           +         |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 |    +  +        +        +  +           +           +           +         |             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  |    +  +        +        +  +           +           +           +         |             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               |    +  +        +        +  M           +           +           +         |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                |    +  +        +        +  +           +           +           +         |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  |    +  +        +        +  +           +           +           +         |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Basophilic Focus                     | X                                                              X        X|             
      Clear Cell Focus                     |          X                                                        X      |             
      Eosinophilic Focus                   | X     X              X              X        X           X               |             
      Hematopoietic Cell Proliferation     |                                              2                           |             
      Infarct                              |                                                                          |             
      Inflammation, Chronic Active         | 4  3     1  2  2  1  3     4  2     3  3  1  2  3     1  3  3  2  3  3  1|             
      Mixed Cell Focus                     |                                                 X                        |             
      Necrosis                             |                                                    4                     |             
      Thrombosis                           |                                                                   4      |             
      Vacuolization Cytoplasmic            |    2                                                                     |             
      Bile Duct, Hyperplasia               | 3  3     2  2  2  2  3     4  1     2  3     1  2        3  4  1  2  3   |             
                                            __________________________________________________________________________|             
   Pancreas                                |    +  +        +        +  +           +           +           +         |             
      Atrophy                              |                                                    2                     |             
      Necrosis                             |                         2                                                |             
                                            __________________________________________________________________________|             
   Salivary Glands                         |    +  +        +        +  +           +           +           +         |             
      Necrosis                             |                         1                                                |             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    |    +  +        +        +  +           +           +           +         |             
      Hyperplasia, Focal                   |                         3                                                |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      |    +  +        +        +  +           +           +           +         |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood Vessel                            |    +  +        +        +  +           +           +           +         |             
      Aorta, Inflammation, Chronic Active  |                                                                4         |             
                                            __________________________________________________________________________|             
   Heart                                   |    +  +        +        +  +           +           +           +         |             
      Degeneration                         |                                                                2         |             
      Atrium, Thrombosis                   |                2                                                         |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Cortex                          |    +  +        +        +  +           +           +           +         |             
      Accessory Adrenal Cortical Nodule    |                         1                                                |             
      Hyperplasia                          |                                        1                                 |             
                                            __________________________________________________________________________|             
   Adrenal Medulla                         |    +  +        +        +  +           +           +           +         |             
      Hyperplasia                          |                                                                          |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      |    +  +        +        +  +           +           +           +         |             
      Hyperplasia                          |       2                                                                  |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  42                                                               
NTP Experiment-Test: 05188-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                       SODIUM XYLENESULFONATE                                  Date: 09/19/95  
Route: SKIN APPLICATION                                                                                           Time: 14:07:09  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 5| 7| 7| 5| 7| 7| 5| 6| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 6| 7| 7| 7|             
                             DAY ON TEST   | 3| 8| 4| 3| 3| 6| 3| 3| 7| 4| 3| 3| 3| 1| 3| 3| 3| 8| 3| 3| 3| 3| 3| 3| 3|             
                                           | 5| 6| 8| 5| 3| 1| 4| 4| 2| 4| 4| 5| 5| 8| 3| 3| 5| 7| 5| 3| 5| 6| 4| 3| 4|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    364                                    | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
    MG/KG                                  | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       |    +  +        M        M  M           M           +           +         |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         |    +  +        +        +  +           +           M           +         |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           |    +  +        +        +  +           +           +           +         |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              |    +  +        +        +  +           +           +           +         |             
      Artery, Inflammation, Chronic Active |                                                                2         |             
                                            __________________________________________________________________________|             
   Preputial Gland                         |    +  +        +        +  M           +           +           +         |             
      Duct, Cyst                           |       4                 3              4                       4         |             
                                            __________________________________________________________________________|             
   Prostate                                |    +  +        +        +  +           +           +           +         |             
      Degeneration                         |                            3                                             |             
      Artery, Inflammation, Chronic Active |                                                                4         |             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         |    +  +        +        +  +           +           +           +         |             
      Degeneration                         |                            4                                             |             
                                            __________________________________________________________________________|             
   Testes                                  |    +  +        +        +  +           +           +           +         |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             |    +  +        +        +  +           +           +           +         |             
      Hyperplasia                          |                2        2              3                                 |             
                                            __________________________________________________________________________|             
   Lymph Node                              |       +                                                        +         |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  |    M  M        +        +  +           M           +           +         |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  |    +  +        +        M  +           +           +           +         |             
      Hematopoietic Cell Proliferation     |                                                    2                     |             
      Hyperplasia, Lymphoid                |                                        4                                 |             
                                            __________________________________________________________________________|             
   Spleen                                  |    +  +        +        +  +           +           +           +         |             
      Hematopoietic Cell Proliferation     |       2        2        4  3           2           3                     |             
                                            __________________________________________________________________________|             
   Thymus                                  |    +  M        M        +  M           +           M           +         |             
      Atrophy                              |    3                    4                                                |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           |    M  +        +        M  M           M           M           M         |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Epidermis, Skin, Site of Application,|                                                                          |             
           Exudate                         |                                                                          |             
      Epidermis, Skin, Site of Application,|                                                                          |             
           Hyperkeratosis                  |                                                                          |             
      Epidermis, Skin, Site of Application,|                                                                          |             
           Hyperplasia                     |                1                                               1         |             
      Subcutaneous Tissue, Edema           |                            3                                             |             
      Subcutaneous Tissue, Inflammation,   |                                                                          |             
           Suppurative                     |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  43                                                               
NTP Experiment-Test: 05188-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                       SODIUM XYLENESULFONATE                                  Date: 09/19/95  
Route: SKIN APPLICATION                                                                                           Time: 14:07:09  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 5| 7| 7| 5| 7| 7| 5| 6| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 6| 7| 7| 7|             
                             DAY ON TEST   | 3| 8| 4| 3| 3| 6| 3| 3| 7| 4| 3| 3| 3| 1| 3| 3| 3| 8| 3| 3| 3| 3| 3| 3| 3|             
                                           | 5| 6| 8| 5| 3| 1| 4| 4| 2| 4| 4| 5| 5| 8| 3| 3| 5| 7| 5| 3| 5| 6| 4| 3| 4|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    364                                    | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
    MG/KG                                  | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    |    +  +        +        +  +           +           +           +         |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   |    +  +        +        +  +           +           +           +         |             
      Inflammation                         |                                                                2         |             
      Artery, Inflammation, Chronic Active |                                                                2         |             
      Neuron, Necrosis                     |    3                                                                     |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    |    +  +     +  +        +  +           +           +           +     +   |             
      Inflammation                         |                2                                                         |             
      Pigmentation, Hemosiderin            |                                        2                                 |             
      Thrombosis                           |                         3                                                |             
      Alveolar Epithelium, Hyperplasia     |                                                    2                     |             
                                            __________________________________________________________________________|             
   Nose                                    |    +  +        +        +  +           +           +           +         |             
                                            __________________________________________________________________________|             
   Trachea                                 |    +  +        +        +  +           +           +           +         |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  |    +  +        +        +  +           +           +           +         |             
      Nephropathy                          |       1        1           1           1                       1         |             
      Pigmentation, Hemosiderin            |                         4                                                |             
      Artery, Inflammation, Chronic Active |                                                                3         |             
      Glomerulus, Thrombosis               |                         2                                                |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         |    +  +        +        +  +           +           +           +         |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  44                                                               
NTP Experiment-Test: 05188-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                       SODIUM XYLENESULFONATE                                  Date: 09/19/95  
Route: SKIN APPLICATION                                                                                           Time: 14:07:09  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|            |
                             DAY ON TEST   | 3| 3| 3| 3| 1| 3| 3| 3| 3| 3| 3| 3| 3| 2| 0| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|            |
                                           | 3| 4| 4| 3| 2| 4| 3| 5| 4| 4| 3| 3| 3| 2| 6| 4| 3| 5| 3| 4| 3| 4| 5| 4| 3|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|      A     |
    364                                    | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      L     |
    MG/KG                                  | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               |             +                          +  +                              |  11        |
                                            __________________________________________________________________________|____________|
   Gallbladder                             |             +                          +  +                              |  11        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  |             +                          +  +                              |  11        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 |             +                          +  +                              |  11        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  |             +                          +  +                              |  11        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               |             +                          +  +                              |  10        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                |             +                          +  +                              |  11        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  |             +                          +  +                              |  11        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Basophilic Focus                     |                                                                          |      3     |
      Clear Cell Focus                     |                                  X                                       |      3     |
      Eosinophilic Focus                   |             X  X                       X                 X     X        X|     12     |
      Hematopoietic Cell Proliferation     |                                                                          |      1  2.0|
      Infarct                              |                                                       4                  |      1  4.0|
      Inflammation, Chronic Active         | 3  3  3  1  3  2  4  4  4  1        3  4  4  1  1        1  2  3  3  3   |     41  2.5|
      Mixed Cell Focus                     |          X                    X     X                                X   |      5     |
      Necrosis                             |                                                                   1      |      2  2.5|
      Thrombosis                           |                                                                          |      1  4.0|
      Vacuolization Cytoplasmic            |                                                                          |      1  2.0|
      Bile Duct, Hyperplasia               | 3  3  3  1  3  2  3  4  3  1        3  4  4     2           2  3  3  3   |     36  2.6|
                                            __________________________________________________________________________|____________|
   Pancreas                                |             +                          +  +                              |  11        |
      Atrophy                              |                                                                          |      1  2.0|
      Necrosis                             |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Salivary Glands                         |             +                          +  +                              |  11        |
      Necrosis                             |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    |             +                          +  +                              |  11        |
      Hyperplasia, Focal                   |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      |             +                          +  +                              |  11        |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood Vessel                            |             +                          +  +                              |  11        |
      Aorta, Inflammation, Chronic Active  |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Heart                                   |             +                          +  +                              |  11        |
      Degeneration                         |                                                                          |      1  2.0|
      Atrium, Thrombosis                   |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Cortex                          |             +                          +  +                              |  11        |
      Accessory Adrenal Cortical Nodule    |                                                                          |      1  1.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  45                                                               
NTP Experiment-Test: 05188-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                       SODIUM XYLENESULFONATE                                  Date: 09/19/95  
Route: SKIN APPLICATION                                                                                           Time: 14:07:09  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|            |
                             DAY ON TEST   | 3| 3| 3| 3| 1| 3| 3| 3| 3| 3| 3| 3| 3| 2| 0| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|            |
                                           | 3| 4| 4| 3| 2| 4| 3| 5| 4| 4| 3| 3| 3| 2| 6| 4| 3| 5| 3| 4| 3| 4| 5| 4| 3|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|      A     |
    364                                    | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      L     |
    MG/KG                                  | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 __________________________________________________________________________________________________________________________________ 
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
                                           |                                                                          |            |
      Hyperplasia                          |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Adrenal Medulla                         |             +                          +  +                              |  11        |
      Hyperplasia                          |                                           2                              |      1  2.0|
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      |             +                          +  +                              |  11        |
      Hyperplasia                          |                                           1                              |      2  1.5|
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       |             +                          +  +                              |   7        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         |             +                          +  +                              |  10        |
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           |             +                          +  +                              |  11        |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Epididymis                              |             +                          +  +                              |  11        |
      Artery, Inflammation, Chronic Active |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Preputial Gland                         |             +                          +  +                              |  10        |
      Duct, Cyst                           |                                                                          |      4  3.8|
                                            __________________________________________________________________________|____________|
   Prostate                                |             +                          +  +                              |  11        |
      Degeneration                         |                                                                          |      1  3.0|
      Artery, Inflammation, Chronic Active |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Seminal Vesicle                         |             +                          +  +                              |  11        |
      Degeneration                         |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Testes                                  |             +                          +  +                              |  11        |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             |             +                          +  +                              |  11        |
      Hyperplasia                          |                                           3                              |      4  2.5|
                                            __________________________________________________________________________|____________|
   Lymph Node                              |                                                                          |   2        |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  |             +                          +  +                              |   8        |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  |             +                          +  +                              |  10        |
      Hematopoietic Cell Proliferation     |                                                                          |      1  2.0|
      Hyperplasia, Lymphoid                |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Spleen                                  |             +                          +  +              +               |  12        |
      Hematopoietic Cell Proliferation     |             3                             2                              |      8  2.6|
                                            __________________________________________________________________________|____________|
   Thymus                                  |             +                          M  +                              |   6        |
      Atrophy                              |                                                                          |      2  3.5|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           |             M                          M  M                              |   2        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  46                                                               
NTP Experiment-Test: 05188-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                       SODIUM XYLENESULFONATE                                  Date: 09/19/95  
Route: SKIN APPLICATION                                                                                           Time: 14:07:09  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|            |
                             DAY ON TEST   | 3| 3| 3| 3| 1| 3| 3| 3| 3| 3| 3| 3| 3| 2| 0| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|            |
                                           | 3| 4| 4| 3| 2| 4| 3| 5| 4| 4| 3| 3| 3| 2| 6| 4| 3| 5| 3| 4| 3| 4| 5| 4| 3|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|      A     |
    364                                    | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      L     |
    MG/KG                                  | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 __________________________________________________________________________________________________________________________________ 
 INTEGUMENTARY SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Epidermis, Skin, Site of Application,|                                                                          |            |
           Exudate                         |                                                       1                  |      1  1.0|
      Epidermis, Skin, Site of Application,|                                                                          |            |
           Hyperkeratosis                  |                               2                                          |      1  2.0|
      Epidermis, Skin, Site of Application,|                                                                          |            |
           Hyperplasia                     |                               2     1                                    |      4  1.3|
      Subcutaneous Tissue, Edema           |                                                                          |      1  3.0|
      Subcutaneous Tissue, Inflammation,   |                                                                          |            |
           Suppurative                     |                                        4                                 |      1  4.0|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    |             +                          +  +                              |  11        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   |             +                          +  +                              |  11        |
      Inflammation                         |                                                                          |      1  2.0|
      Artery, Inflammation, Chronic Active |                                                                          |      1  2.0|
      Neuron, Necrosis                     |                                                                          |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    |       +     +                          +  +        +                     |  15        |
      Inflammation                         |                                                                          |      1  2.0|
      Pigmentation, Hemosiderin            |                                                                          |      1  2.0|
      Thrombosis                           |                                                                          |      1  3.0|
      Alveolar Epithelium, Hyperplasia     |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Nose                                    |             +                          +  +                              |  11        |
                                            __________________________________________________________________________|____________|
   Trachea                                 |             +                          +  +                              |  11        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Harderian Gland                         |                                        +                                 |   1        |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  |             +                          +  +                              |  11        |
      Nephropathy                          |             1                          1  1                              |      8  1.0|
      Pigmentation, Hemosiderin            |                                                                          |      1  4.0|
      Artery, Inflammation, Chronic Active |                                                                          |      1  3.0|
      Glomerulus, Thrombosis               |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         |             +                          +  +                              |  11        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  47                                                               
NTP Experiment-Test: 05188-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                       SODIUM XYLENESULFONATE                                  Date: 09/19/95  
Route: SKIN APPLICATION                                                                                           Time: 14:07:09  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 7| 7| 7| 7| 5| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7|             
                             DAY ON TEST   | 3| 3| 3| 3| 3| 3| 6| 3| 0| 4| 3| 3| 3| 2| 3| 3| 3| 3| 3| 3| 9| 3| 3| 3| 3|             
                                           | 4| 4| 3| 3| 4| 5| 9| 5| 7| 3| 4| 5| 3| 1| 5| 3| 4| 3| 3| 3| 1| 3| 3| 3| 4|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    727                                    | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|             
    MG/KG                                  | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Gallbladder                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                                    2                     |             
      Basophilic Focus                     |                                     X                                   X|             
      Clear Cell Focus                     |                X                          X     X  X  X  X               |             
      Eosinophilic Focus                   |                X        X     X                                X         |             
      Inflammation, Chronic Active         | 2  1     1  3  3        2     3     2  2  3  3  2  4  3  3  3  3  4  2  3|             
      Mixed Cell Focus                     |                                                 X              X        X|             
      Necrosis                             |    2     1                 3                                4            |             
      Vacuolization Cytoplasmic            |                                                                          |             
      Bile Duct, Hyperplasia               | 1           3  3        4     3     3  2  2  2  2  3  2  2  3  4  4  1  3|             
                                            __________________________________________________________________________|             
   Mesentery                               |                   +                                               +      |             
      Hemorrhage                           |                   4                                                      |             
      Artery, Inflammation, Chronic Active |                   4                                                      |             
      Vein, Thrombosis                     |                                                                   2      |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              | 1                                                                        |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Focal                   |                4                    2                                    |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Erosion                              |                                                                          |             
      Mineralization                       |                                                                          |             
      Artery, Inflammation, Chronic Active |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood Vessel                            | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Aorta, Inflammation, Chronic Active  |                   4                                                      |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Degeneration                         |                                                                          |             
      Mineralization                       |                                                             1            |             
      Artery, Inflammation, Chronic Active |                                                                          |             
      Atrium, Thrombosis                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  48                                                               
NTP Experiment-Test: 05188-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                       SODIUM XYLENESULFONATE                                  Date: 09/19/95  
Route: SKIN APPLICATION                                                                                           Time: 14:07:09  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 7| 7| 7| 7| 5| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7|             
                             DAY ON TEST   | 3| 3| 3| 3| 3| 3| 6| 3| 0| 4| 3| 3| 3| 2| 3| 3| 3| 3| 3| 3| 9| 3| 3| 3| 3|             
                                           | 4| 4| 3| 3| 4| 5| 9| 5| 7| 3| 4| 5| 3| 1| 5| 3| 4| 3| 3| 3| 1| 3| 3| 3| 4|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    727                                    | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|             
    MG/KG                                  | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
      Accessory Adrenal Cortical Nodule    |                                                                          |             
      Degeneration, Cystic                 |                                                                1         |             
      Hemorrhage                           |    4                                                                     |             
      Hyperplasia                          |                      1        1  1  1     1  1              1  1     2   |             
      Inflammation, Chronic Active         |                                                                          |             
      Capsule, Hyperplasia, Adenomatous    |             2                    2                                       |             
                                            __________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                                 1                        |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |    2                 1     2     1  1                                    |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  M  +|             
      Cyst                                 |          2                                                               |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                                    1              1      |             
      Pars Distalis, Hyperplasia           |                      3              2                                    |             
      Pars Intermedia, Hyperplasia         |                                                                          |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Follicular Cell, Hyperplasia         |                2     1           1                 2     1               |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Granuloma Sperm                      |                                                                          |             
      Artery, Inflammation, Chronic Active |                                                                          |             
                                            __________________________________________________________________________|             
   Preputial Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M|             
      Duct, Cyst                           |                4                                      4                  |             
                                            __________________________________________________________________________|             
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Artery, Inflammation, Chronic Active |                   4                                                      |             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                                                                          |             
      Artery, Inflammation, Chronic Active |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |    3     2              3  3  3     3  3  3     3  3     3  4  3     3   |             
      Thrombosis                           |                      2                                                   |             
                                            __________________________________________________________________________|             
   Lymph Node                              |                                                                          |             
      Mediastinal, Angiectasis             |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M|             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Histiocytic             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  49                                                               
NTP Experiment-Test: 05188-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                       SODIUM XYLENESULFONATE                                  Date: 09/19/95  
Route: SKIN APPLICATION                                                                                           Time: 14:07:09  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 7| 7| 7| 7| 5| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7|             
                             DAY ON TEST   | 3| 3| 3| 3| 3| 3| 6| 3| 0| 4| 3| 3| 3| 2| 3| 3| 3| 3| 3| 3| 9| 3| 3| 3| 3|             
                                           | 4| 4| 3| 3| 4| 5| 9| 5| 7| 3| 4| 5| 3| 1| 5| 3| 4| 3| 3| 3| 1| 3| 3| 3| 4|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    727                                    | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|             
    MG/KG                                  | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Hyperplasia, Plasma Cell             |                                              3                           |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hematopoietic Cell Proliferation     |    4     2              4  4  1     2  3        1        1     3  2  1   |             
      Lymphoid Follicle, Depletion Cellular|                                                                          |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  M  +  +  +  +  M  M  M  +  +  +  +  M  M  +  +  M  +  M  M  +  +|             
      Atrophy                              |    3                                   3                    3            |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | M  M  +  M  M  M  +  M  M  M  M  +  M  M  +  +  +  M  M  M  M  +  M  M  M|             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Epidermis, Skin, Site of Application,|                                                                          |             
           Exudate                         |                                                                          |             
      Epidermis, Skin, Site of Application,|                                                                          |             
           Hyperplasia                     |    1                                         1  1                        |             
      Epidermis, Skin, Site of Application,|                                                                          |             
           Ulcer                           |                                                                          |             
      Subcutaneous Tissue, Edema           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Corpus Callosum, Degeneration        |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Alveolar Epithelium, Hyperplasia     |                                                                          |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Suppurative            |                                                                          |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ear                                     |          +                                                               |             
      Inflammation                         |                                                                          |             
                                            __________________________________________________________________________|             
   Harderian Gland                         | +                                                              +         |             
      Hyperplasia                          |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                      1                 1        2              1     1   |             
      Glomerulosclerosis                   |                                                                          |             
      Hydronephrosis                       |                   4                                                      |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  50                                                               
NTP Experiment-Test: 05188-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                       SODIUM XYLENESULFONATE                                  Date: 09/19/95  
Route: SKIN APPLICATION                                                                                           Time: 14:07:09  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 7| 7| 7| 7| 5| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7|             
                             DAY ON TEST   | 3| 3| 3| 3| 3| 3| 6| 3| 0| 4| 3| 3| 3| 2| 3| 3| 3| 3| 3| 3| 9| 3| 3| 3| 3|             
                                           | 4| 4| 3| 3| 4| 5| 9| 5| 7| 3| 4| 5| 3| 1| 5| 3| 4| 3| 3| 3| 1| 3| 3| 3| 4|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    727                                    | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|             
    MG/KG                                  | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
      Infarct                              |                                                          1               |             
      Mineralization                       |                                                             2            |             
      Nephropathy                          | 1  1  1  1  1  1     1  1  1  1  1  1  1  1  1  1  1  1  1     1  1  1  1|             
      Pigmentation, Hemosiderin            |                                                                          |             
      Artery, Inflammation, Chronic Active |                   3                                                      |             
      Renal Tubule, Hyperplasia            |                                                                          |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  51                                                               
NTP Experiment-Test: 05188-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                       SODIUM XYLENESULFONATE                                  Date: 09/19/95  
Route: SKIN APPLICATION                                                                                           Time: 14:07:09  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 6| 7| 7| 7| 6| 7| 7| 4| 7| 6| 7| 7| 7| 7| 5|            |
                             DAY ON TEST   | 3| 3| 1| 3| 0| 3| 3| 3| 3| 6| 3| 3| 3| 3| 2| 3| 3| 5| 3| 5| 3| 3| 1| 3| 8|            |
                                           | 5| 4| 2| 5| 7| 5| 3| 3| 4| 4| 1| 3| 5| 4| 1| 4| 5| 7| 3| 8| 4| 5| 2| 3| 5|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2|      A     |
    727                                    | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|      L     |
    MG/KG                                  | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Gallbladder                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Angiectasis                          |                                                                          |      1  2.0|
      Basophilic Focus                     |    X                                               X                     |      4     |
      Clear Cell Focus                     |                         X                                      X         |      8     |
      Eosinophilic Focus                   |          X              X     X        X                             X   |      9     |
      Inflammation, Chronic Active         | 2  3  3  4  1  3  3  1  1  2  1  1  1  4  1     4  4  1  3     3  3  1  3|     43  2.4|
      Mixed Cell Focus                     | X        X              X                       X                        |      7     |
      Necrosis                             |       4                    2                                         1  2|      8  2.4|
      Vacuolization Cytoplasmic            |                                     2                                    |      1  2.0|
      Bile Duct, Hyperplasia               | 2  3  4  3     2  2  1  1  3  3     1  4  2     3  4     3     2  4     1|     37  2.6|
                                            __________________________________________________________________________|____________|
   Mesentery                               |                               +           +                              |   4        |
      Hemorrhage                           |                                                                          |      1  4.0|
      Artery, Inflammation, Chronic Active |                                                                          |      1  4.0|
      Vein, Thrombosis                     |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Atrophy                              |             2                             1           2                  |      4  1.5|
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Atrophy                              |                                        3                                 |      1  3.0|
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia, Focal                   |                                                                          |      2  3.0|
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Erosion                              |       3                                                                  |      1  3.0|
      Mineralization                       |       2                                                                  |      1  2.0|
      Artery, Inflammation, Chronic Active |                                  1                                       |      1  1.0|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood Vessel                            | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Aorta, Inflammation, Chronic Active  |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Degeneration                         |                                        1                                 |      1  1.0|
      Mineralization                       |                               1                                          |      2  1.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  52                                                               
NTP Experiment-Test: 05188-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                       SODIUM XYLENESULFONATE                                  Date: 09/19/95  
Route: SKIN APPLICATION                                                                                           Time: 14:07:09  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 6| 7| 7| 7| 6| 7| 7| 4| 7| 6| 7| 7| 7| 7| 5|            |
                             DAY ON TEST   | 3| 3| 1| 3| 0| 3| 3| 3| 3| 6| 3| 3| 3| 3| 2| 3| 3| 5| 3| 5| 3| 3| 1| 3| 8|            |
                                           | 5| 4| 2| 5| 7| 5| 3| 3| 4| 4| 1| 3| 5| 4| 1| 4| 5| 7| 3| 8| 4| 5| 2| 3| 5|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2|      A     |
    727                                    | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|      L     |
    MG/KG                                  | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 __________________________________________________________________________________________________________________________________ 
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |            |
                                           |                                                                          |            |
      Artery, Inflammation, Chronic Active |    2                                                                     |      1  2.0|
      Atrium, Thrombosis                   |                            4                                             |      1  4.0|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Accessory Adrenal Cortical Nodule    |                                           2                              |      1  2.0|
      Degeneration, Cystic                 |                                                                          |      1  1.0|
      Hemorrhage                           |                                                                          |      1  4.0|
      Hyperplasia                          |    3        1        1  1  1     1  2                 1     1     1      |     19  1.2|
      Inflammation, Chronic Active         |                         1                                                |      1  1.0|
      Capsule, Hyperplasia, Adenomatous    |                                     3                       1            |      4  2.0|
                                            __________________________________________________________________________|____________|
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia                          |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia                          |             3           2        1                    3                  |      9  1.8|
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +  +  M  M  +  +  +  M  +  +  +  +  +  +  +  M  +  +  M  +  +  M  +|  42        |
      Cyst                                 |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cyst                                 |                                                                          |      2  1.0|
      Pars Distalis, Hyperplasia           |                                                                          |      2  2.5|
      Pars Intermedia, Hyperplasia         |                               2  2                                       |      2  2.0|
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Follicular Cell, Hyperplasia         |                2                 1           1  1           2            |     10  1.4|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Granuloma Sperm                      |    2           1                                                         |      2  1.5|
      Artery, Inflammation, Chronic Active |                                  3                                       |      1  3.0|
                                            __________________________________________________________________________|____________|
   Preputial Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Duct, Cyst                           | 3                                            3              3           3|      6  3.3|
                                            __________________________________________________________________________|____________|
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Artery, Inflammation, Chronic Active |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Atrophy                              |                      2                                      4            |      2  3.0|
      Artery, Inflammation, Chronic Active |                                  1                                       |      1  1.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  53                                                               
NTP Experiment-Test: 05188-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                       SODIUM XYLENESULFONATE                                  Date: 09/19/95  
Route: SKIN APPLICATION                                                                                           Time: 14:07:09  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 6| 7| 7| 7| 6| 7| 7| 4| 7| 6| 7| 7| 7| 7| 5|            |
                             DAY ON TEST   | 3| 3| 1| 3| 0| 3| 3| 3| 3| 6| 3| 3| 3| 3| 2| 3| 3| 5| 3| 5| 3| 3| 1| 3| 8|            |
                                           | 5| 4| 2| 5| 7| 5| 3| 3| 4| 4| 1| 3| 5| 4| 1| 4| 5| 7| 3| 8| 4| 5| 2| 3| 5|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2|      A     |
    727                                    | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|      L     |
    MG/KG                                  | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 __________________________________________________________________________________________________________________________________ 
 GENITAL SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia                          | 3              3           3           2  2           3  3           2  3|     23  2.9|
      Thrombosis                           |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Lymph Node                              |          +  +  +                                                         |   3        |
      Mediastinal, Angiectasis             |          4                                                               |      1  4.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  M  +  M  +  +  +  M  +  M  +  M  +  M|  42        |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  M  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +|  47        |
      Hyperplasia, Histiocytic             |                                                 3                        |      1  3.0|
      Hyperplasia, Plasma Cell             |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Hematopoietic Cell Proliferation     | 2           2  2           3        2  1           2  2  3  3     1  3  4|     25  2.3|
      Lymphoid Follicle, Depletion Cellular|                               4                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Thymus                                  | M  +  M  +  +  +  +  M  +  +  +  M  +  +  M  +  +  +  +  M  +  +  +  M  +|  34        |
      Atrophy                              |                            4  4                                         2|      6  3.2|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  +  M  +  M  M  M  M  M  M  M  M  +  +  M  M  M  +  M  +  M  M  M  M  +|  15        |
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Epidermis, Skin, Site of Application,|                                                                          |            |
           Exudate                         |             3                                                            |      1  3.0|
      Epidermis, Skin, Site of Application,|                                                                          |            |
           Hyperplasia                     |             3                                      1                     |      5  1.4|
      Epidermis, Skin, Site of Application,|                                                                          |            |
           Ulcer                           |             3                                                            |      1  3.0|
      Subcutaneous Tissue, Edema           |                               4                                          |      1  4.0|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Skeletal Muscle                         |                               +           +                       +      |   3        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Corpus Callosum, Degeneration        |                                        2                                 |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Alveolar Epithelium, Hyperplasia     |                               1                                1         |      2  1.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  54                                                               
NTP Experiment-Test: 05188-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                       SODIUM XYLENESULFONATE                                  Date: 09/19/95  
Route: SKIN APPLICATION                                                                                           Time: 14:07:09  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 6| 7| 7| 7| 6| 7| 7| 4| 7| 6| 7| 7| 7| 7| 5|            |
                             DAY ON TEST   | 3| 3| 1| 3| 0| 3| 3| 3| 3| 6| 3| 3| 3| 3| 2| 3| 3| 5| 3| 5| 3| 3| 1| 3| 8|            |
                                           | 5| 4| 2| 5| 7| 5| 3| 3| 4| 4| 1| 3| 5| 4| 1| 4| 5| 7| 3| 8| 4| 5| 2| 3| 5|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2|      A     |
    727                                    | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|      L     |
    MG/KG                                  | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 __________________________________________________________________________________________________________________________________ 
 RESPIRATORY SYSTEM - cont                 |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inflammation, Suppurative            |                         2                                                |      1  2.0|
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Ear                                     |             +                                                            |   2        |
      Inflammation                         |             3                                                            |      1  3.0|
                                            __________________________________________________________________________|____________|
   Harderian Gland                         |                                     +                                    |   3        |
      Hyperplasia                          |                                     1                                    |      1  1.0|
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cyst                                 |    1                    2                       1                        |      8  1.3|
      Glomerulosclerosis                   |       1                    2           4                          2      |      4  2.3|
      Hydronephrosis                       |                                                                          |      1  4.0|
      Infarct                              |                                                                          |      1  1.0|
      Mineralization                       | 1     1                                                           1      |      4  1.3|
      Nephropathy                          | 1  1  1  1  1     1  2  1        1  1  1     1  1     1  1  1  1  1  2  1|     43  1.0|
      Pigmentation, Hemosiderin            |                                        2                                 |      1  2.0|
      Artery, Inflammation, Chronic Active |                                                                          |      1  3.0|
      Renal Tubule, Hyperplasia            |                                                       2                  |      1  2.0|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  55                                                               
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