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TDMS Study 05188-05 Pathology Tables

NTP Experiment-Test: 05188-05         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                       SODIUM XYLENESULFONATE                                  Date: 04/04/96
Route: SKIN APPLICATION                                                                                           Time: 04:28:15




       Facility:  Battelle Columbus Laboratory

       Chemical CAS #:  1300-72-7

       Lock Date:  07/13/93

       Cage Range:  All

       Reasons For Removal:    All

       Removal Date Range:     All

       Treatment Groups:       Include All




































a  Number of animals examined microscopically at site and number of animals with lesion

                                                              Page   1


NTP Experiment-Test: 05188-05         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                       SODIUM XYLENESULFONATE                                  Date: 04/04/96  
Route: SKIN APPLICATION                                                                                           Time: 04:28:15  
____________________________________________________________________________________________________________________________________

         FISCHER 344 RATS FEMALE                   0 MG/KG      60 MG/KG     120          240                                       
                                                                             MG/KG        MG/KG                                     
____________________________________________________________________________________________________________________________________

DISPOSITION SUMMARY                                                                                                                 

  Animals Initially In Study                          50           50           50           50                                     
  Early Deaths                                                                                                                      
    Moribund Sacrifice                                14           10           15           12                                     
    Natural Death                                     13           24           18           22                                     
    Accidently Killed                                  1                                                                            
  Survivors                                                                                                                         
    Terminal Sacrifice                                22           15           17           16                                     
    Natural Death                                                   1                                                               

  Animals Examined Microscopically                    50           50           50           50                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Intestine Large, Colon                             (50)         (35)         (33)         (50)                                   
      Parasite Metazoan                                2 (4%)       1 (3%)                    3 (6%)                                
   Intestine Large, Rectum                            (50)         (35)         (33)         (50)                                   
      Parasite Metazoan                                4 (8%)       3 (9%)       1 (3%)       3 (6%)                                
   Intestine Large, Cecum                             (50)         (35)         (33)         (50)                                   
      Inflammation, Chronic Active                                  1 (3%)       1 (3%)       1 (2%)                                
      Ulcer                                                         1 (3%)                                                          
   Intestine Small, Duodenum                          (50)         (35)         (33)         (50)                                   
      Inflammation, Chronic Active                                               1 (3%)                                             
      Ulcer                                            1 (2%)                    1 (3%)                                             
   Liver                                              (50)         (35)         (33)         (50)                                   
      Angiectasis                                                                             1 (2%)                                
      Basophilic Focus                                30 (60%)     12 (34%)     11 (33%)     26 (52%)                               
      Clear Cell Focus                                 1 (2%)                                 1 (2%)                                
      Hematopoietic Cell Proliferation                                                        1 (2%)                                
      Hepatodiaphragmatic Nodule                      10 (20%)      6 (17%)     11 (33%)      3 (6%)                                
      Inflammation, Chronic                           21 (42%)     17 (49%)     19 (58%)     24 (48%)                               
      Mixed Cell Focus                                                                        1 (2%)                                
      Necrosis                                         3 (6%)       1 (3%)       3 (9%)       3 (6%)                                
      Pigmentation, Hemosiderin                        3 (6%)       1 (3%)                                                          
      Pigmentation, Melanin                            1 (2%)                                                                       
      Bile Duct, Hyperplasia                          28 (56%)     13 (37%)     17 (52%)     21 (42%)                               
      Central Vein, Thrombosis                         1 (2%)                                                                       
      Hepatocyte, Hyperplasia                          2 (4%)                    1 (3%)       1 (2%)                                
      Hepatocyte, Vacuolization Cytoplasmic           15 (30%)                   4 (12%)      4 (8%)                                
      Hepatocyte, Centrilobular, Degeneration,                                                                                      
           Fatty                                       4 (8%)       1 (3%)       3 (9%)       2 (4%)                                
      Portal Vein, Thrombosis                                                                 1 (2%)                                
   Mesentery                                          (2)          (4)          (4)          (4)                                    
      Mineralization                                   1 (50%)                   2 (50%)      1 (25%)                               
      Artery, Inflammation, Chronic Active                          1 (25%)                                                         
      Fat, Inflammation, Chronic Active                1 (50%)      2 (50%)      1 (25%)      2 (50%)                               

a  Number of animals examined microscopically at site and number of animals with lesion                                             

                                                             Page    2                                                              
NTP Experiment-Test: 05188-05         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                       SODIUM XYLENESULFONATE                                  Date: 04/04/96  
Route: SKIN APPLICATION                                                                                           Time: 04:28:15  
____________________________________________________________________________________________________________________________________

         FISCHER 344 RATS FEMALE                   0 MG/KG      60 MG/KG     120          240                                       
                                                                             MG/KG        MG/KG                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ALIMENTARY SYSTEM - CONT                                                                                                            
      Fat, Necrosis                                    1 (50%)                   2 (50%)                                            
   Oral Mucosa                                        (1)                                    (2)                                    
      Gingival, Inflammation, Chronic Active                                                  2 (100%)                              
   Pancreas                                           (50)         (35)         (33)         (50)                                   
      Cyst                                                                       1 (3%)                                             
      Hypertrophy, Focal                                                                      1 (2%)                                
      Inflammation, Chronic Active                                  1 (3%)       1 (3%)                                             
      Acinus, Atrophy                                 12 (24%)      3 (9%)       5 (15%)      8 (16%)                               
      Artery, Inflammation, Chronic Active             1 (2%)                                 1 (2%)                                
   Stomach, Forestomach                               (50)         (35)         (33)         (50)                                   
      Inflammation, Chronic Active                     2 (4%)       4 (11%)      3 (9%)       4 (8%)                                
      Ulcer                                            2 (4%)       2 (6%)       3 (9%)       3 (6%)                                
      Epithelium, Hyperplasia                          2 (4%)       4 (11%)      3 (9%)       5 (10%)                               
   Stomach, Glandular                                 (50)         (35)         (33)         (50)                                   
      Inflammation, Chronic Active                                  1 (3%)       1 (3%)                                             
      Mineralization                                   1 (2%)                    1 (3%)                                             
      Necrosis                                         1 (2%)       1 (3%)                                                          
      Ulcer                                                                      1 (3%)                                             
      Epithelium, Erosion                              1 (2%)       1 (3%)                                                          
      Epithelium, Hemorrhage                           1 (2%)                                                                       
      Epithelium, Necrosis                             1 (2%)                                                                       
   Tooth                                              (1)                                    (1)                                    
      Inflammation                                                                            1 (100%)                              
      Peridontal Tissue, Inflammation, Chronic                                                                                      
          Active                                       1 (100%)                                                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Blood Vessel                                       (50)         (35)         (33)         (50)                                   
      Mineralization                                   1 (2%)                    1 (3%)                                             
   Heart                                              (50)         (35)         (33)         (50)                                   
      Cardiomyopathy, Chronic                         16 (32%)     10 (29%)     15 (45%)     23 (46%)                               
      Inflammation, Chronic Active                                               1 (3%)                                             
      Mineralization                                   1 (2%)                    1 (3%)                                             
      Atrium, Thrombosis                               4 (8%)       1 (3%)       2 (6%)       2 (4%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Cortex                                     (50)         (35)         (33)         (50)                                   
      Accessory Adrenal Cortical Nodule                2 (4%)                    1 (3%)       1 (2%)                                
      Atrophy                                          1 (2%)                                                                       
      Degeneration, Fatty                             24 (48%)     12 (34%)      7 (21%)     14 (28%)                               
      Hyperplasia                                     17 (34%)     10 (29%)      6 (18%)     17 (34%)                               
      Hypertrophy                                      1 (2%)                    1 (3%)       1 (2%)                                
      Karyomegaly                                                                1 (3%)       1 (2%)                                

a  Number of animals examined microscopically at site and number of animals with lesion                                             

                                                             Page    3                                                              
NTP Experiment-Test: 05188-05         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                       SODIUM XYLENESULFONATE                                  Date: 04/04/96  
Route: SKIN APPLICATION                                                                                           Time: 04:28:15  
____________________________________________________________________________________________________________________________________

         FISCHER 344 RATS FEMALE                   0 MG/KG      60 MG/KG     120          240                                       
                                                                             MG/KG        MG/KG                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ENDOCRINE SYSTEM - CONT                                                                                                             
      Necrosis                                         1 (2%)                                                                       
      Pigmentation, Hemosiderin                        1 (2%)                                                                       
      Pigmentation, Lipofuscin                         3 (6%)       2 (6%)       4 (12%)      7 (14%)                               
   Adrenal Medulla                                    (50)         (35)         (33)         (50)                                   
      Hyperplasia                                      9 (18%)      3 (9%)       1 (3%)       5 (10%)                               
   Islets, Pancreatic                                 (50)         (35)         (33)         (50)                                   
      Hyperplasia                                      1 (2%)                                 1 (2%)                                
   Parathyroid Gland                                  (48)         (32)         (31)         (45)                                   
      Hyperplasia                                      1 (2%)                    1 (3%)                                             
   Pituitary Gland                                    (50)         (35)         (33)         (50)                                   
      Angiectasis                                     36 (72%)     21 (60%)     19 (58%)     31 (62%)                               
      Mineralization                                   1 (2%)                    1 (3%)                                             
      Pigmentation, Hematoidin                         1 (2%)       1 (3%)                    1 (2%)                                
      Pars Distalis, Atypia Cellular                   1 (2%)                                                                       
      Pars Distalis, Cyst                             21 (42%)     11 (31%)     15 (45%)     29 (58%)                               
      Pars Distalis, Hyperplasia                       9 (18%)     11 (31%)      7 (21%)     17 (34%)                               
      Pars Distalis, Pigmentation, Hemosiderin        32 (64%)     20 (57%)     20 (61%)     31 (62%)                               
      Pars Distalis, Thrombosis                                     1 (3%)                                                          
      Pars Intermedia, Cyst                                         2 (6%)                    2 (4%)                                
   Thyroid Gland                                      (50)         (35)         (33)         (50)                                   
      Ultimobranchial Cyst                             1 (2%)                                                                       
      C-Cell, Hyperplasia                              7 (14%)      5 (14%)      5 (15%)      8 (16%)                               
      Follicle, Cyst                                                1 (3%)                    1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Clitoral Gland                                     (49)         (50)         (50)         (50)                                   
      Hyperplasia                                      2 (4%)       2 (4%)       1 (2%)      10 (20%)                               
      Inflammation, Chronic Active                     6 (12%)      4 (8%)       4 (8%)       7 (14%)                               
      Duct, Cyst                                       1 (2%)                    2 (4%)       2 (4%)                                
      Duct, Hyperplasia                                                          2 (4%)                                             
   Ovary                                              (50)         (35)         (33)         (50)                                   
      Cyst                                             3 (6%)       1 (3%)       2 (6%)       4 (8%)                                
      Inflammation, Chronic Active                                               1 (3%)                                             
      Interstitial Cell, Hyperplasia                                             2 (6%)                                             
   Uterus                                             (50)         (35)         (33)         (50)                                   
      Cyst                                             2 (4%)                    1 (3%)                                             
   Vagina                                             (1)          (1)          (1)                                                 
      Inflammation, Suppurative                                     1 (100%)                                                        
____________________________________________________________________________________________________________________________________
                                                                                                                                    

a  Number of animals examined microscopically at site and number of animals with lesion                                             

                                                             Page    4                                                              
NTP Experiment-Test: 05188-05         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                       SODIUM XYLENESULFONATE                                  Date: 04/04/96  
Route: SKIN APPLICATION                                                                                           Time: 04:28:15  
____________________________________________________________________________________________________________________________________

         FISCHER 344 RATS FEMALE                   0 MG/KG      60 MG/KG     120          240                                       
                                                                             MG/KG        MG/KG                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (50)         (35)         (33)         (48)                                   
      Hyperplasia                                     19 (38%)      4 (11%)     12 (36%)     10 (21%)                               
      Inflammation, Granulomatous                                                             1 (2%)                                
   Lymph Node                                         (45)         (32)         (27)         (43)                                   
      Lumbar, Hyperplasia, Lymphoid                                                           1 (2%)                                
      Mediastinal, Hyperplasia, Plasma Cell                                                   1 (2%)                                
      Mediastinal, Pigmentation, Hemosiderin          44 (98%)     31 (97%)     27 (100%)    40 (93%)                               
      Pancreatic, Pigmentation, Hemosiderin            1 (2%)                                                                       
      Renal, Pigmentation, Hemosiderin                 1 (2%)                                                                       
   Lymph Node, Mandibular                             (50)         (35)         (33)         (50)                                   
      Pigmentation, Hemosiderin                        2 (4%)       5 (14%)      6 (18%)      4 (8%)                                
   Lymph Node, Mesenteric                             (49)         (35)         (33)         (48)                                   
      Ectasia                                          1 (2%)                                                                       
      Inflammation, Suppurative                        1 (2%)                                                                       
      Pigmentation, Hemosiderin                        1 (2%)                                                                       
   Spleen                                             (50)         (35)         (33)         (50)                                   
      Accessory Spleen                                 2 (4%)                                                                       
      Fibrosis                                         3 (6%)                                                                       
      Hematopoietic Cell Proliferation                 2 (4%)       4 (11%)      3 (9%)       1 (2%)                                
      Necrosis                                                      1 (3%)                                                          
      Pigmentation, Hemosiderin                        4 (8%)       5 (14%)      9 (27%)     11 (22%)                               
      Capsule, Fibrosis                                             1 (3%)                                                          
      Capsule, Inflammation, Chronic Active                         1 (3%)                                                          
      Lymphoid Follicle, Depletion Cellular                         1 (3%)                                                          
   Thymus                                             (49)         (35)         (31)         (49)                                   
      Cyst                                             1 (2%)       1 (3%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Mammary Gland                                      (50)         (35)         (33)         (50)                                   
      Hyperplasia, Cystic                             42 (84%)     23 (66%)     27 (82%)     42 (84%)                               
      Duct, Cyst                                       1 (2%)                                 1 (2%)                                
   Skin                                               (50)         (50)         (50)         (50)                                   
      Hyperkeratosis                                                             1 (2%)                                             
      Hyperplasia, Basal Cell                                                    1 (2%)                                             
      Inflammation, Chronic Active                                               1 (2%)                                             
      Epidermis, Hyperplasia                                                     1 (2%)                                             
      Epidermis, Ulcer                                                           1 (2%)                                             
      Epidermis, Skin, Site of Application, Exudate                                           2 (4%)                                
      Epidermis, Skin, Site of Application,                                                                                         
          Hyperplasia                                  1 (2%)                    4 (8%)       5 (10%)                               
      Epidermis, Skin, Site of Application,                                                                                         
          Inflammation, Chronic Active                                                        1 (2%)                                
      Epidermis, Skin, Site of Application, Ulcer      1 (2%)                    2 (4%)       2 (4%)                                
      Sebaceous Gland, Skin, Site of Application,                                                                                   

a  Number of animals examined microscopically at site and number of animals with lesion                                             

                                                             Page    5                                                              
NTP Experiment-Test: 05188-05         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                       SODIUM XYLENESULFONATE                                  Date: 04/04/96  
Route: SKIN APPLICATION                                                                                           Time: 04:28:15  
____________________________________________________________________________________________________________________________________

         FISCHER 344 RATS FEMALE                   0 MG/KG      60 MG/KG     120          240                                       
                                                                             MG/KG        MG/KG                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
INTEGUMENTARY SYSTEM - CONT                                                                                                         
           Hyperplasia                                 2 (4%)                    2 (4%)       2 (4%)                                
      Skin, Site of Application, Inflammation,                                                                                      
           Chronic Active                              1 (2%)                    2 (4%)       2 (4%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Bone                                               (50)         (35)         (33)         (48)                                   
      Fibrous Osteodystrophy                           1 (2%)                    1 (3%)                                             
      Osteopetrosis                                    1 (2%)                    1 (3%)                                             
      Femur, Osteosclerosis                                         1 (3%)                    1 (2%)                                
      Femur, Tibia, Osteosclerosis                                                            1 (2%)                                
      Joint, Arthrosis                                                           1 (3%)                                             
      Joint, Tarsal, Arthrosis                                                   1 (3%)                                             
      Tibia, Fracture                                               1 (3%)                                                          
   Skeletal Muscle                                                 (1)                                                              
      Inflammation, Chronic Active                                  1 (100%)                                                        
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (50)         (35)         (33)         (50)                                   
      Hemorrhage, Acute                                1 (2%)                                 1 (2%)                                
      Hydrocephalus                                    8 (16%)      5 (14%)      3 (9%)       7 (14%)                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (50)         (35)         (33)         (50)                                   
      Congestion, Acute                               13 (26%)     14 (40%)      8 (24%)     16 (32%)                               
      Foreign Body                                                               1 (3%)                                             
      Inflammation, Chronic Active                     3 (6%)       2 (6%)       2 (6%)       4 (8%)                                
      Inflammation, Granulomatous                                                             2 (4%)                                
      Inflammation, Suppurative                        1 (2%)                                                                       
      Mineralization                                   1 (2%)                    1 (3%)                                             
      Pigmentation, Hemosiderin                                                  1 (3%)                                             
      Alveolar Epithelium, Hyperplasia                              1 (3%)                    4 (8%)                                
      Alveolus, Hemorrhage, Acute                                                1 (3%)                                             
      Alveolus, Infiltration Cellular, Histiocyte     32 (64%)     23 (66%)     20 (61%)     39 (78%)                               
      Interstitium, Inflammation, Chronic Active       9 (18%)      4 (11%)      2 (6%)       5 (10%)                               
   Nose                                               (50)         (35)         (33)         (50)                                   
      Inflammation, Chronic Active                     4 (8%)                    2 (6%)       6 (12%)                               
      Nasolacrimal Duct, Inflammation, Chronic                                                                                      
          Active                                       1 (2%)                                                                       
      Nasolacrimal Duct, Inflammation, Suppurative    10 (20%)      3 (9%)       1 (3%)       6 (12%)                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    

a  Number of animals examined microscopically at site and number of animals with lesion                                             

                                                             Page    6                                                              
NTP Experiment-Test: 05188-05         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                       SODIUM XYLENESULFONATE                                  Date: 04/04/96  
Route: SKIN APPLICATION                                                                                           Time: 04:28:15  
____________________________________________________________________________________________________________________________________

         FISCHER 344 RATS FEMALE                   0 MG/KG      60 MG/KG     120          240                                       
                                                                             MG/KG        MG/KG                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Eye                                                (3)          (2)          (2)          (5)                                    
      Cornea, Inflammation, Suppurative                1 (33%)                                                                      
      Lens, Cataract                                   1 (33%)      2 (100%)     2 (100%)     3 (60%)                               
      Retina, Degeneration                             1 (33%)      1 (50%)      2 (100%)     4 (80%)                               
      Retina, Hemorrhage                                                                      1 (20%)                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (50)         (35)         (33)         (50)                                   
      Infarct                                                       1 (3%)                                                          
      Mineralization                                  10 (20%)     22 (63%)      7 (21%)     11 (22%)                               
      Nephropathy, Chronic                            44 (88%)     25 (71%)     27 (82%)     37 (74%)                               
      Pelvis, Transitional Epithelium, Hyperplasia                  1 (3%)                                                          
      Renal Tubule, Pigmentation, Hemosiderin                                    1 (3%)                                             
                                                                                                                                    

a  Number of animals examined microscopically at site and number of animals with lesion                                             

                                                             Page    7                                                              
NTP Experiment-Test: 05188-05         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                       SODIUM XYLENESULFONATE                                  Date: 04/04/96  
Route: SKIN APPLICATION                                                                                           Time: 04:28:15  
____________________________________________________________________________________________________________________________________

         FISCHER 344 RATS MALE                     0 MG/KG      60 MG/KG     120          240                                       
                                                                             MG/KG        MG/KG                                     
____________________________________________________________________________________________________________________________________

DISPOSITION SUMMARY                                                                                                                 

  Animals Initially In Study                          50           50           50           50                                     
  Early Deaths                                                                                                                      
    Natural Death                                     15            8           19           10                                     
    Moribund Sacrifice                                28           25           22           30                                     
  Survivors                                                                                                                         
    Terminal Sacrifice                                 7           17            9           10                                     

  Animals Examined Microscopically                    50           50           50           50                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Intestine Large, Colon                             (50)         (33)         (41)         (50)                                   
      Parasite Metazoan                                4 (8%)       1 (3%)       2 (5%)       3 (6%)                                
   Intestine Large, Rectum                            (50)         (33)         (41)         (49)                                   
      Parasite Metazoan                                             2 (6%)       1 (2%)       2 (4%)                                
   Intestine Large, Cecum                             (50)         (33)         (41)         (50)                                   
      Inflammation, Chronic Active                                  1 (3%)       2 (5%)       1 (2%)                                
      Ulcer                                                         1 (3%)       1 (2%)       1 (2%)                                
   Intestine Small, Duodenum                          (50)         (33)         (41)         (50)                                   
      Inflammation, Chronic Active                     1 (2%)       1 (3%)                                                          
      Ulcer                                            1 (2%)       1 (3%)                                                          
   Intestine Small, Jejunum                           (50)         (33)         (41)         (50)                                   
      Diverticulum                                                               1 (2%)                                             
      Inflammation, Chronic Active                     1 (2%)       1 (3%)                                                          
      Necrosis                                         1 (2%)                                                                       
      Ulcer                                                         1 (3%)                                                          
   Intestine Small, Ileum                             (50)         (33)         (41)         (50)                                   
      Inflammation, Chronic Active                                  2 (6%)                    1 (2%)                                
      Parasite Metazoan                                                                       1 (2%)                                
      Ulcer                                                                                   1 (2%)                                
   Liver                                              (50)         (45)         (47)         (50)                                   
      Angiectasis                                                                             1 (2%)                                
      Basophilic Focus                                 3 (6%)                    3 (6%)       6 (12%)                               
      Clear Cell Focus                                 3 (6%)                                 1 (2%)                                
      Degeneration, Cystic                            12 (24%)      4 (9%)       8 (17%)      9 (18%)                               
      Hematopoietic Cell Proliferation                 1 (2%)       1 (2%)                    2 (4%)                                
      Hepatodiaphragmatic Nodule                       6 (12%)      2 (4%)       3 (6%)       9 (18%)                               
      Inflammation, Chronic                           20 (40%)      9 (20%)     10 (21%)     16 (32%)                               
      Necrosis                                         8 (16%)      4 (9%)       4 (9%)       2 (4%)                                
      Pigmentation, Hemosiderin                                     1 (2%)                                                          
      Bile Duct, Hyperplasia                          43 (86%)     29 (64%)     32 (68%)     43 (86%)                               
      Central Vein, Thrombosis                                      1 (2%)                                                          
      Hepatocyte, Hyperplasia                          1 (2%)       1 (2%)                    2 (4%)                                
      Hepatocyte, Vacuolization Cytoplasmic           21 (42%)     11 (24%)     16 (34%)     20 (40%)                               
      Hepatocyte, Centrilobular, Degeneration,                                                                                      

a  Number of animals examined microscopically at site and number of animals with lesion                                             

                                                             Page    8                                                              
NTP Experiment-Test: 05188-05         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                       SODIUM XYLENESULFONATE                                  Date: 04/04/96  
Route: SKIN APPLICATION                                                                                           Time: 04:28:15  
____________________________________________________________________________________________________________________________________

         FISCHER 344 RATS MALE                     0 MG/KG      60 MG/KG     120          240                                       
                                                                             MG/KG        MG/KG                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ALIMENTARY SYSTEM - CONT                                                                                                            
           Fatty                                       2 (4%)       4 (9%)                                                          
      Hepatocyte, Centrilobular, Necrosis              1 (2%)       3 (7%)                                                          
   Mesentery                                          (8)          (7)          (9)          (8)                                    
      Mineralization                                   3 (38%)      1 (14%)      2 (22%)      2 (25%)                               
      Artery, Inflammation, Chronic Active                          1 (14%)                                                         
      Fat, Inflammation, Chronic Active                4 (50%)      3 (43%)      4 (44%)      2 (25%)                               
      Fat, Necrosis                                                              1 (11%)                                            
   Oral Mucosa                                        (2)          (1)          (3)          (6)                                    
      Gingival, Dysplasia                                                        1 (33%)                                            
      Gingival, Inflammation, Chronic Active           1 (50%)      1 (100%)     2 (67%)      4 (67%)                               
   Pancreas                                           (50)         (33)         (41)         (50)                                   
      Inflammation, Chronic Active                                               1 (2%)                                             
      Acinus, Atrophy                                 25 (50%)     13 (39%)     16 (39%)     13 (26%)                               
      Acinus, Hyperplasia                              3 (6%)                    2 (5%)       1 (2%)                                
      Artery, Inflammation, Chronic Active                                       2 (5%)                                             
   Stomach, Forestomach                               (50)         (33)         (41)         (50)                                   
      Cyst                                             1 (2%)                                 1 (2%)                                
      Inflammation, Chronic Active                    12 (24%)     11 (33%)     11 (27%)     13 (26%)                               
      Mineralization                                   1 (2%)                    2 (5%)                                             
      Perforation                                                                             1 (2%)                                
      Ulcer                                            8 (16%)     10 (30%)     10 (24%)     11 (22%)                               
      Epithelium, Hyperplasia                         17 (34%)     11 (33%)     10 (24%)     17 (34%)                               
   Stomach, Glandular                                 (50)         (33)         (41)         (50)                                   
      Inflammation, Chronic Active                     3 (6%)       4 (12%)                   1 (2%)                                
      Mineralization                                   9 (18%)      1 (3%)       5 (12%)      4 (8%)                                
      Necrosis                                                      1 (3%)       1 (2%)       2 (4%)                                
      Ulcer                                            2 (4%)       3 (9%)                    1 (2%)                                
      Epithelium, Erosion                              1 (2%)       4 (12%)      3 (7%)       2 (4%)                                
      Epithelium, Hyperplasia                                       1 (3%)                                                          
   Tongue                                                          (1)                                                              
      Cyst                                                          1 (100%)                                                        
   Tooth                                              (1)                                                                           
      Inflammation, Chronic Active                     1 (100%)                                                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Blood Vessel                                       (50)         (33)         (41)         (50)                                   
      Mineralization                                   8 (16%)                   5 (12%)      2 (4%)                                
      Thrombosis                                                                 1 (2%)                                             
   Heart                                              (50)         (33)         (41)         (50)                                   
      Cardiomyopathy, Chronic                         29 (58%)     21 (64%)     27 (66%)     28 (56%)                               
      Inflammation, Chronic Active                     1 (2%)       1 (3%)                    1 (2%)                                
      Mineralization                                   7 (14%)      1 (3%)       4 (10%)      1 (2%)                                
      Atrium, Thrombosis                               4 (8%)       6 (18%)      6 (15%)      8 (16%)                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    

a  Number of animals examined microscopically at site and number of animals with lesion                                             

                                                             Page    9                                                              
NTP Experiment-Test: 05188-05         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                       SODIUM XYLENESULFONATE                                  Date: 04/04/96  
Route: SKIN APPLICATION                                                                                           Time: 04:28:15  
____________________________________________________________________________________________________________________________________

         FISCHER 344 RATS MALE                     0 MG/KG      60 MG/KG     120          240                                       
                                                                             MG/KG        MG/KG                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Cortex                                     (50)         (33)         (41)         (50)                                   
      Accessory Adrenal Cortical Nodule                1 (2%)                                 1 (2%)                                
      Atrophy                                                                    1 (2%)                                             
      Degeneration, Fatty                             34 (68%)     23 (70%)     29 (71%)     33 (66%)                               
      Hyperplasia                                     25 (50%)      6 (18%)     17 (41%)     17 (34%)                               
      Hypertrophy                                                   2 (6%)       1 (2%)                                             
      Necrosis                                                                                1 (2%)                                
   Adrenal Medulla                                    (50)         (33)         (41)         (50)                                   
      Hyperplasia                                     30 (60%)     10 (30%)     17 (41%)     25 (50%)                               
   Islets, Pancreatic                                 (50)         (33)         (41)         (50)                                   
      Hyperplasia                                                   2 (6%)       5 (12%)      1 (2%)                                
   Parathyroid Gland                                  (46)         (29)         (39)         (45)                                   
      Hyperplasia                                     13 (28%)      3 (10%)      8 (21%)      5 (11%)                               
   Pituitary Gland                                    (50)         (33)         (41)         (50)                                   
      Angiectasis                                     38 (76%)     26 (79%)     30 (73%)     35 (70%)                               
      Hemorrhage                                                    1 (3%)                                                          
      Mineralization                                   5 (10%)                   1 (2%)                                             
      Necrosis                                                      1 (3%)       1 (2%)                                             
      Pigmentation, Hematoidin                         2 (4%)       1 (3%)       1 (2%)                                             
      Pars Distalis, Atrophy                                                     1 (2%)                                             
      Pars Distalis, Cyst                              8 (16%)      5 (15%)     10 (24%)     14 (28%)                               
      Pars Distalis, Hyperplasia                      12 (24%)      5 (15%)      7 (17%)     17 (34%)                               
      Pars Distalis, Pigmentation, Hemosiderin        33 (66%)     20 (61%)     26 (63%)     35 (70%)                               
      Pars Distalis, Thrombosis                                     1 (3%)       1 (2%)                                             
      Pars Intermedia, Cyst                            2 (4%)       2 (6%)                    3 (6%)                                
      Pars Nervosa, Cyst                               1 (2%)                                                                       
   Thyroid Gland                                      (50)         (33)         (41)         (50)                                   
      C-Cell, Hyperplasia                              7 (14%)      8 (24%)      7 (17%)     12 (24%)                               
      Follicle, Cyst                                   2 (4%)                    1 (2%)       4 (8%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Coagulating Gland                                                            (1)          (2)                                    
      Inflammation, Chronic Active                                               1 (100%)     2 (100%)                              
   Epididymis                                         (50)         (33)         (41)         (50)                                   
      Atrophy                                         25 (50%)     10 (30%)     16 (39%)     25 (50%)                               
      Inflammation, Chronic Active                                  1 (3%)                                                          
      Mineralization                                   1 (2%)                    2 (5%)                                             
   Preputial Gland                                    (50)         (33)         (40)         (50)                                   
      Cyst                                                                                    2 (4%)                                

a  Number of animals examined microscopically at site and number of animals with lesion                                             

                                                             Page   10                                                              
NTP Experiment-Test: 05188-05         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                       SODIUM XYLENESULFONATE                                  Date: 04/04/96  
Route: SKIN APPLICATION                                                                                           Time: 04:28:15  
____________________________________________________________________________________________________________________________________

         FISCHER 344 RATS MALE                     0 MG/KG      60 MG/KG     120          240                                       
                                                                             MG/KG        MG/KG                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
GENITAL SYSTEM - CONT                                                                                                               
      Hyperplasia                                      1 (2%)       1 (3%)       1 (3%)       2 (4%)                                
      Inflammation, Chronic Active                    47 (94%)     27 (82%)     38 (95%)     46 (92%)                               
      Duct, Cyst                                       1 (2%)       1 (3%)       3 (8%)                                             
   Prostate                                           (50)         (33)         (41)         (50)                                   
      Atrophy                                                                                 1 (2%)                                
      Cyst                                                                                    3 (6%)                                
      Inflammation, Chronic Active                    49 (98%)     32 (97%)     38 (93%)     47 (94%)                               
      Mineralization                                   1 (2%)                                                                       
   Seminal Vesicle                                    (50)         (33)         (41)         (50)                                   
      Atrophy                                          3 (6%)       7 (21%)     11 (27%)     13 (26%)                               
      Inflammation, Chronic Active                     2 (4%)       1 (3%)                                                          
      Mineralization                                   1 (2%)                                                                       
   Testes                                             (50)         (33)         (41)         (50)                                   
      Artery, Inflammation, Chronic                   10 (20%)      2 (6%)       8 (20%)      9 (18%)                               
      Germinal Epithelium, Atrophy                    20 (40%)      6 (18%)     19 (46%)     13 (26%)                               
      Interstitial Cell, Hyperplasia                  20 (40%)     13 (39%)     11 (27%)     14 (28%)                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (50)         (32)         (41)         (50)                                   
      Hyperplasia                                     25 (50%)     13 (41%)     16 (39%)     38 (76%)                               
   Lymph Node                                         (41)         (25)         (31)         (41)                                   
      Lumbar, Hyperplasia, Lymphoid                                 1 (4%)                                                          
      Mediastinal, Atrophy                                                                    1 (2%)                                
      Mediastinal, Ectasia                             1 (2%)                                                                       
      Mediastinal, Infiltration Cellular,                                                                                           
          Histiocyte                                                1 (4%)                                                          
      Mediastinal, Pigmentation, Hemosiderin          37 (90%)     23 (92%)     27 (87%)     36 (88%)                               
      Renal, Ectasia                                                             2 (6%)       1 (2%)                                
      Renal, Erythrophagocytosis                                                              1 (2%)                                
      Renal, Pigmentation, Hemosiderin                                           1 (3%)       1 (2%)                                
   Lymph Node, Mesenteric                             (50)         (33)         (41)         (50)                                   
      Atrophy                                                                                 1 (2%)                                
      Ectasia                                          1 (2%)       3 (9%)       2 (5%)       6 (12%)                               
      Inflammation, Granulomatous                                                             1 (2%)                                
   Spleen                                             (50)         (46)         (47)         (50)                                   
      Fibrosis                                         6 (12%)                   4 (9%)       8 (16%)                               
      Hematopoietic Cell Proliferation                12 (24%)      6 (13%)      7 (15%)     10 (20%)                               
      Pigmentation, Hemosiderin                        4 (8%)                    1 (2%)       4 (8%)                                
      Lymphoid Follicle, Depletion Cellular            1 (2%)                                                                       
      Red Pulp, Depletion Cellular                                                            2 (4%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    

a  Number of animals examined microscopically at site and number of animals with lesion                                             

                                                             Page   11                                                              
NTP Experiment-Test: 05188-05         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                       SODIUM XYLENESULFONATE                                  Date: 04/04/96  
Route: SKIN APPLICATION                                                                                           Time: 04:28:15  
____________________________________________________________________________________________________________________________________

         FISCHER 344 RATS MALE                     0 MG/KG      60 MG/KG     120          240                                       
                                                                             MG/KG        MG/KG                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Mammary Gland                                      (50)         (32)         (40)         (50)                                   
      Hyperplasia, Cystic                             42 (84%)     26 (81%)     35 (88%)     41 (82%)                               
      Inflammation, Chronic Active                                                            1 (2%)                                
      Duct, Cyst                                                    1 (3%)       3 (8%)       2 (4%)                                
   Skin                                               (50)         (50)         (50)         (50)                                   
      Hyperkeratosis                                                1 (2%)                                                          
      Epidermis, Skin, Site of Application,                                                                                         
          Hyperplasia                                               1 (2%)       1 (2%)       2 (4%)                                
      Sebaceous Gland, Skin, Site of Application,                                                                                   
           Hyperplasia                                 1 (2%)       1 (2%)                                                          
      Skin, Site of Application, Inflammation,                                                                                      
           Chronic Active                                           1 (2%)                                                          
      Subcutaneous Tissue, Inflammation, Chronic                                                                                    
          Active                                                                              1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Bone                                               (50)         (32)         (41)         (50)                                   
      Fibrous Osteodystrophy                          10 (20%)      1 (3%)       9 (22%)      8 (16%)                               
      Femur, Osteosclerosis                                                                   1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (50)         (33)         (41)         (50)                                   
      Hemorrhage, Acute                                             1 (3%)                    4 (8%)                                
      Hydrocephalus                                   11 (22%)     12 (36%)      9 (22%)      5 (10%)                               
      Mineralization                                   1 (2%)                                                                       
      Necrosis                                         1 (2%)                                                                       
   Spinal Cord                                        (1)          (1)          (1)                                                 
      Axon, Degeneration                               1 (100%)                  1 (100%)                                           
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (50)         (33)         (41)         (50)                                   
      Congestion, Acute                               10 (20%)      9 (27%)     17 (41%)      6 (12%)                               
      Inflammation, Chronic Active                     3 (6%)       1 (3%)       2 (5%)       3 (6%)                                
      Inflammation, Granulomatous                      2 (4%)                    1 (2%)                                             
      Inflammation, Suppurative                                                  1 (2%)       1 (2%)                                
      Mineralization                                   7 (14%)                   5 (12%)                                            
      Necrosis                                                                   1 (2%)                                             
      Thrombosis                                                                              1 (2%)                                
      Alveolar Epithelium, Hyperplasia                 3 (6%)       2 (6%)       1 (2%)       3 (6%)                                
      Alveolus, Hemorrhage, Acute                      3 (6%)       1 (3%)       1 (2%)                                             

a  Number of animals examined microscopically at site and number of animals with lesion                                             

                                                             Page   12                                                              
NTP Experiment-Test: 05188-05         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                       SODIUM XYLENESULFONATE                                  Date: 04/04/96  
Route: SKIN APPLICATION                                                                                           Time: 04:28:15  
____________________________________________________________________________________________________________________________________

         FISCHER 344 RATS MALE                     0 MG/KG      60 MG/KG     120          240                                       
                                                                             MG/KG        MG/KG                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
RESPIRATORY SYSTEM - CONT                                                                                                           
      Alveolus, Infiltration Cellular, Histiocyte     24 (48%)     10 (30%)     16 (39%)     16 (32%)                               
      Interstitium, Inflammation, Chronic Active       7 (14%)                   4 (10%)      3 (6%)                                
   Nose                                               (50)         (32)         (41)         (50)                                   
      Inflammation, Chronic Active                     5 (10%)      8 (25%)      4 (10%)      5 (10%)                               
      Polyp Inflammatory                               1 (2%)                                                                       
      Thrombosis                                                    1 (3%)       1 (2%)                                             
      Nasolacrimal Duct, Inflammation, Suppurative     5 (10%)      3 (9%)       3 (7%)       3 (6%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Eye                                                (3)          (2)          (2)          (1)                                    
      Anterior Chamber, Hemorrhage, Acute              1 (33%)                                                                      
      Cornea, Inflammation, Suppurative                1 (33%)                                                                      
      Lens, Cataract                                   2 (67%)      1 (50%)      1 (50%)      1 (100%)                              
      Retina, Degeneration                             2 (67%)      2 (100%)     1 (50%)      1 (100%)                              
   Harderian Gland                                    (1)          (1)                       (1)                                    
      Inflammation, Chronic                            1 (100%)     1 (100%)                                                        
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (50)         (33)         (41)         (50)                                   
      Accumulation, Hyaline Droplet                                              1 (2%)                                             
      Infarct                                                                                 2 (4%)                                
      Mineralization                                   4 (8%)       3 (9%)       2 (5%)       1 (2%)                                
      Nephropathy, Chronic                            50 (100%)    32 (97%)     41 (100%)    50 (100%)                              
      Cortex, Cyst                                     8 (16%)      1 (3%)       1 (2%)      10 (20%)                               
   Urinary Bladder                                    (50)         (33)         (41)         (50)                                   
      Inflammation, Chronic Active                     1 (2%)                                                                       
      Mineralization                                   1 (2%)                                                                       
                                                                                                                                    

a  Number of animals examined microscopically at site and number of animals with lesion                                             

                                                             Page   13                                                              
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