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https://ntp.niehs.nih.gov/go/6769

TDMS Study 05188-05 Pathology Tables

                                                    NEOPLASMS BY INDIVIDUAL ANIMAL
                                                       SODIUM XYLENESULFONATE


NTP Experiment-Test: 05188-05                                                                                     Report: PEIRPT04
Study Type: CHRONIC                                                                                               Date: 09/19/95
Route: SKIN APPLICATION                                                                                           Time: 20:55:17


                                                           CORE STUDY


       Facility:  Battelle Columbus Laboratory

       Chemical CAS #:  1300-72-7

       Lock Date:  07/13/93

       Cage Range:  All

       Reasons For Removal:    All

       Removal Date Range:     All

       Treatment Groups:       Include All































Note:  Animals arranged according to CID number

                                                             Page   1
NTP Experiment-Test: 05188-05                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                       SODIUM XYLENESULFONATE                                  Date: 09/19/95  
Route: SKIN APPLICATION                                                                                           Time: 20:55:17  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 7| 7| 7| 7| 5| 6| 7| 5| 7| 6| 6| 4| 7| 6| 4| 7| 7| 6| 4| 6| 4| 7| 7|             
                             DAY ON TEST   | 3| 7| 3| 3| 3| 3| 9| 9| 3| 7| 1| 5| 5| 9| 3| 2| 8| 3| 3| 4| 2| 0| 8| 3| 3|             
                                           | 6| 4| 6| 6| 6| 6| 1| 2| 6| 5| 8| 6| 7| 0| 6| 9| 5| 6| 6| 6| 0| 5| 8| 6| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    0 MG/KG                                | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |    X        X  X              X     X        X  X  X                    X|             
                                            __________________________________________________________________________|             
   Mesentery                               |    +                                                                     |             
                                            __________________________________________________________________________|             
   Oral Mucosa                             |                                                                          |             
      Gingival, Squamous Cell Carcinoma    |                                                                          |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                               X                                         X|             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                         X|             
                                            __________________________________________________________________________|             
   Tooth                                   |                                                       +                  |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood Vessel                            | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                               X                                         X|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Adenoma                              |                                                                          |             
      Leukemia Mononuclear                 |             X                                   X                       X|             
                                            __________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |             X                                   X                        |             
      Pheochromocytoma Benign              |                                                                          |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Carcinoma                            |                                                                X         |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                 X                       X|             
      Pars Distalis, Adenoma               | X     X  X  X  X  X  X  X  X     X  X     X  X  X  X     X  X  X        X|             
      Pars Distalis, Adenoma, Multiple     |                                                       X              X   |             
      Pars Distalis, Carcinoma             |                                                                          |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      C-Cell, Adenoma                      |             X           X                                                |             
      Follicular Cell, Adenoma             |       X                                                                  |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   2                                                               
NTP Experiment-Test: 05188-05                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                       SODIUM XYLENESULFONATE                                  Date: 09/19/95  
Route: SKIN APPLICATION                                                                                           Time: 20:55:17  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 7| 7| 7| 7| 5| 6| 7| 5| 7| 6| 6| 4| 7| 6| 4| 7| 7| 6| 4| 6| 4| 7| 7|             
                             DAY ON TEST   | 3| 7| 3| 3| 3| 3| 9| 9| 3| 7| 1| 5| 5| 9| 3| 2| 8| 3| 3| 4| 2| 0| 8| 3| 3|             
                                           | 6| 4| 6| 6| 6| 6| 1| 2| 6| 5| 8| 6| 7| 0| 6| 9| 5| 6| 6| 6| 0| 5| 8| 6| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    0 MG/KG                                | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Clitoral Gland                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +|             
      Adenoma                              |                                                                          |             
      Leukemia Mononuclear                 |                                                                         X|             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibroma                              |          X                                                               |             
      Polyp Stromal                        |             X                                                            |             
                                            __________________________________________________________________________|             
   Vagina                                  |    +                                                                     |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                 X                       X|             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +     +  +  +  +|             
      Lumbar, Leukemia Mononuclear         |                                                                         X|             
      Mediastinal, Leukemia Mononuclear    |    X                                            X  X                    X|             
      Pancreatic, Leukemia Mononuclear     |                                                                         X|             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                    X                    X|             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |    X                                               X                    X|             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |    X        X  X           X  X     X        X  X  X                    X|             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                         X|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Carcinoma                            |                                                                          |             
      Fibroadenoma                         |             X  X                                   X                     |             
      Fibroadenoma, Multiple               |          X                                                           X  X|             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Pinna, Squamous Cell Papilloma       |       X                                                                  |             
      Subcutaneous Tissue, Schwannoma      |                                                                          |             
          Malignant                        |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Humerus, Osteosarcoma                |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Astrocytoma Malignant                |                                                                          |             
      Carcinoma, Metastatic, Pituitary     |                                                                          |             
          Gland                            |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   3                                                               
NTP Experiment-Test: 05188-05                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                       SODIUM XYLENESULFONATE                                  Date: 09/19/95  
Route: SKIN APPLICATION                                                                                           Time: 20:55:17  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 7| 7| 7| 7| 5| 6| 7| 5| 7| 6| 6| 4| 7| 6| 4| 7| 7| 6| 4| 6| 4| 7| 7|             
                             DAY ON TEST   | 3| 7| 3| 3| 3| 3| 9| 9| 3| 7| 1| 5| 5| 9| 3| 2| 8| 3| 3| 4| 2| 0| 8| 3| 3|             
                                           | 6| 4| 6| 6| 6| 6| 1| 2| 6| 5| 8| 6| 7| 0| 6| 9| 5| 6| 6| 6| 0| 5| 8| 6| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    0 MG/KG                                | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
      Leukemia Mononuclear                 |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Alveolar/Bronchiolar Adenoma         |          X                                                               |             
      Leukemia Mononuclear                 |    X        X  X              X     X        X  X  X                    X|             
      Osteosarcoma, Metastatic, Bone       |                                                                          |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                                                                +         |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |             X  X              X     X        X  X  X                    X|             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SYSTEMIC LESIONS                          |                                                                          |             
                                            __________________________________________________________________________|             
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |    X        X  X           X  X     X        X  X  X                    X|             
 _____________________________________________________________________________________________________________________|             
                                                             Page   4                                                               
NTP Experiment-Test: 05188-05                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                       SODIUM XYLENESULFONATE                                  Date: 09/19/95  
Route: SKIN APPLICATION                                                                                           Time: 20:55:17  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 3| 4| 7| 6| 7| 7| 7| 7| 3| 6| 7| 4| 7| 7| 4| 5| 7| 7| 7| 6| 4| 7| 7| 7|            |
                             DAY ON TEST   | 4| 9| 2| 3| 9| 3| 0| 3| 3| 0| 9| 3| 0| 3| 3| 8| 4| 3| 3| 3| 8| 9| 3| 1| 3|            |
                                           | 5| 3| 0| 6| 8| 6| 8| 6| 6| 3| 3| 6| 8| 6| 2| 0| 8| 6| 6| 6| 2| 0| 6| 9| 6|            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     T      |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|     A      |
    0 MG/KG                                | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|     L      |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Leukemia Mononuclear                 |             X           X        X        X              X           X  X|         16 |
                                            __________________________________________________________________________|____________|
   Mesentery                               |                                                          +               |   2        |
                                            __________________________________________________________________________|____________|
   Oral Mucosa                             |                                                    +                     |   1        |
      Gingival, Squamous Cell Carcinoma    |                                                    X                     |          1 |
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Leukemia Mononuclear                 |                                                                          |          2 |
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Leukemia Mononuclear                 |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Tooth                                   |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood Vessel                            | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Leukemia Mononuclear                 |                                                                          |          2 |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Adenoma                              |                                                                   X      |          1 |
      Leukemia Mononuclear                 |                                                                          |          3 |
                                            __________________________________________________________________________|____________|
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Leukemia Mononuclear                 |                                                                          |          2 |
      Pheochromocytoma Benign              |                                                                   X      |          1 |
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Carcinoma                            |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Leukemia Mononuclear                 |             X                                                           X|          4 |
      Pars Distalis, Adenoma               |          X        X           X           X  X  X  X        X        X  X|         29 |
      Pars Distalis, Adenoma, Multiple     |             X           X                                         X      |          5 |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page   5                                                               
NTP Experiment-Test: 05188-05                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                       SODIUM XYLENESULFONATE                                  Date: 09/19/95  
Route: SKIN APPLICATION                                                                                           Time: 20:55:17  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 3| 4| 7| 6| 7| 7| 7| 7| 3| 6| 7| 4| 7| 7| 4| 5| 7| 7| 7| 6| 4| 7| 7| 7|            |
                             DAY ON TEST   | 4| 9| 2| 3| 9| 3| 0| 3| 3| 0| 9| 3| 0| 3| 3| 8| 4| 3| 3| 3| 8| 9| 3| 1| 3|            |
                                           | 5| 3| 0| 6| 8| 6| 8| 6| 6| 3| 3| 6| 8| 6| 2| 0| 8| 6| 6| 6| 2| 0| 6| 9| 6|            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     T      |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|     A      |
    0 MG/KG                                | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|     L      |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 __________________________________________________________________________________________________________________________________ 
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
                                           |                                                                          |            |
      Pars Distalis, Carcinoma             |       X                                                                  |          1 |
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      C-Cell, Adenoma                      |             X  X              X  X                 X              X  X  X|         10 |
      Follicular Cell, Adenoma             |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Clitoral Gland                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Adenoma                              |                                        X                                 |          1 |
      Leukemia Mononuclear                 |                                                                         X|          2 |
                                            __________________________________________________________________________|____________|
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Fibroma                              |                                                                          |          1 |
      Polyp Stromal                        |                                     X                                    |          2 |
                                            __________________________________________________________________________|____________|
   Vagina                                  |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Leukemia Mononuclear                 |             X           X                 X                             X|          6 |
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +     +  +  +  +  +  +  +  +  +  +  +     +  +     +  +  +  +  +  +  +  +|  45        |
      Lumbar, Leukemia Mononuclear         |                                                                          |          1 |
      Mediastinal, Leukemia Mononuclear    |                                                                         X|          5 |
      Pancreatic, Leukemia Mononuclear     |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Leukemia Mononuclear                 |                                                                          |          2 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Leukemia Mononuclear                 |                         X                                                |          4 |
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Leukemia Mononuclear                 |             X           X        X        X              X           X  X|         17 |
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +|  49        |
      Leukemia Mononuclear                 |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Carcinoma                            |                                           X                              |          1 |
      Fibroadenoma                         |             X     X              X        X              X  X  X  X  X   |         12 |
      Fibroadenoma, Multiple               |                                                    X                     |          4 |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page   6                                                               
NTP Experiment-Test: 05188-05                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                       SODIUM XYLENESULFONATE                                  Date: 09/19/95  
Route: SKIN APPLICATION                                                                                           Time: 20:55:17  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 3| 4| 7| 6| 7| 7| 7| 7| 3| 6| 7| 4| 7| 7| 4| 5| 7| 7| 7| 6| 4| 7| 7| 7|            |
                             DAY ON TEST   | 4| 9| 2| 3| 9| 3| 0| 3| 3| 0| 9| 3| 0| 3| 3| 8| 4| 3| 3| 3| 8| 9| 3| 1| 3|            |
                                           | 5| 3| 0| 6| 8| 6| 8| 6| 6| 3| 3| 6| 8| 6| 2| 0| 8| 6| 6| 6| 2| 0| 6| 9| 6|            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     T      |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|     A      |
    0 MG/KG                                | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|     L      |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 __________________________________________________________________________________________________________________________________ 
 INTEGUMENTARY SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Pinna, Squamous Cell Papilloma       |                                                                          |          1 |
      Subcutaneous Tissue, Schwannoma      |                                                                          |            |
          Malignant                        |    X                                                                     |          1 |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Humerus, Osteosarcoma                |                                     X                                    |          1 |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Astrocytoma Malignant                |                            X                                             |          1 |
      Carcinoma, Metastatic, Pituitary     |                                                                          |            |
          Gland                            |       X                                                                  |          1 |
      Leukemia Mononuclear                 |                                                                         X|          1 |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Alveolar/Bronchiolar Adenoma         |                                                                          |          1 |
      Leukemia Mononuclear                 |             X           X        X        X              X              X|         15 |
      Osteosarcoma, Metastatic, Bone       |                                     X                                    |          1 |
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Eye                                     |                               +                             +            |   3        |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Leukemia Mononuclear                 |             X           X        X        X                             X|         13 |
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 __________________________________________________________________________________________________________________________________ 
 SYSTEMIC LESIONS                          |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Leukemia Mononuclear                 |             X           X        X        X              X           X  X|         17 |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page   7                                                               
NTP Experiment-Test: 05188-05                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                       SODIUM XYLENESULFONATE                                  Date: 09/19/95  
Route: SKIN APPLICATION                                                                                           Time: 20:55:17  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 2| 7| 7| 5| 6| 6| 6| 7| 4| 5| 6| 7| 7| 7| 7| 4| 7| 7| 6| 7| 7| 4| 6| 6|             
                             DAY ON TEST   | 8| 7| 3| 3| 2| 4| 2| 6| 3| 4| 9| 4| 0| 3| 3| 3| 9| 3| 3| 2| 3| 3| 4| 4| 4|             
                                           | 5| 7| 6| 6| 8| 4| 6| 6| 5| 7| 0| 3| 8| 6| 6| 6| 7| 6| 6| 2| 6| 6| 6| 5| 5|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    60 MG/KG                               | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +     +  +  +  +  +  +  +  +  +           +        +        +  +  +|             
      Periesophageal Tissue, Lipoma        |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +     +  +  +  +  +  +  +  +  +           +        +        +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +     +  +  +  +  +  +  +  +  +           +        +        +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +     +  +  +  +  +  +  +  +  +           +        +        +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +     +  +  +  +  +  +  +  +  +           +        +        +  +  +|             
      Leukemia Mononuclear                 |                      X                                                   |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +     +  +  +  +  +  +  +  +  +           +        +        +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +     +  +  +  +  +  +  +  +  +           +        +        +  +  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +     +  +  +  +  +  +  +  +  +           +        +        +  +  +|             
      Leukemia Mononuclear                 |       X              X                          X                        |             
                                            __________________________________________________________________________|             
   Mesentery                               |                      +     +        +                                    |             
      Leukemia Mononuclear                 |                      X                                                   |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +     +  +  +  +  +  +  +  +  +           +        +        +  +  +|             
      Leukemia Mononuclear                 |                      X                                                   |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +     +  +  +  +  +  +  +  +  +           +        +        +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +     +  +  +  +  +  +  +  +  +           +        +        +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +     +  +  +  +  +  +  +  +  +           +        +        +  +  +|             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood Vessel                            | +  +  +     +  +  +  +  +  +  +  +  +           +        +        +  +  +|             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +     +  +  +  +  +  +  +  +  +           +        +        +  +  +|             
      Leukemia Mononuclear                 |                      X                                                   |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +     +  +  +  +  +  +  +  +  +           +        +        +  +  +|             
      Adenoma                              |                                                                          |             
      Leukemia Mononuclear                 |                      X                                                   |             
                                            __________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +     +  +  +  +  +  +  +  +  +           +        +        +  +  +|             
      Leukemia Mononuclear                 |                      X                                                   |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +     +  +  +  +  +  +  +  +  +           +        +        +  +  +|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +     +  +  +  +  M  +  M  +  M           +        +        +  +  +|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +     +  +  +  +  +  +  +  +  +           +        +        +  +  +|             
      Leukemia Mononuclear                 |                      X                          X                        |             
      Pars Distalis, Adenoma               |       X     X                 X  X  X                    X           X  X|             
      Pars Distalis, Adenoma, Multiple     |                                                                          |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +     +  +  +  +  +  +  +  +  +           +        +        +  +  +|             
      C-Cell, Adenoma                      |                                                                         X|             
      Follicular Cell, Adenoma             |                         X           X                                    |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   8                                                               
NTP Experiment-Test: 05188-05                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                       SODIUM XYLENESULFONATE                                  Date: 09/19/95  
Route: SKIN APPLICATION                                                                                           Time: 20:55:17  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 2| 7| 7| 5| 6| 6| 6| 7| 4| 5| 6| 7| 7| 7| 7| 4| 7| 7| 6| 7| 7| 4| 6| 6|             
                             DAY ON TEST   | 8| 7| 3| 3| 2| 4| 2| 6| 3| 4| 9| 4| 0| 3| 3| 3| 9| 3| 3| 2| 3| 3| 4| 4| 4|             
                                           | 5| 7| 6| 6| 8| 4| 6| 6| 5| 7| 0| 3| 8| 6| 6| 6| 7| 6| 6| 2| 6| 6| 6| 5| 5|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    60 MG/KG                               | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Clitoral Gland                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Adenoma                              |                   X                                      X     X         |             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +     +  +  +  +  +  +  +  +  +           +        +        +  +  +|             
      Leukemia Mononuclear                 |                      X                          X                        |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +     +  +  +  +  +  +  +  +  +           +        +        +  +  +|             
      Polyp Stromal                        |                                                                          |             
      Sarcoma Stromal                      |                                                                   X      |             
                                            __________________________________________________________________________|             
   Vagina                                  |                      +                                                   |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +     +  +  +  +  +  +  +  +  +           +        +        +  +  +|             
      Leukemia Mononuclear                 |                      X                          X                        |             
                                            __________________________________________________________________________|             
   Lymph Node                              |    +  +     +  +  +  +  +  +  +  +  +           +        +        +  +  +|             
      Mediastinal, Leukemia Mononuclear    |                                                 X                        |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +     +  +  +  +  +  +  +  +  +           +        +        +  +  +|             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +     +  +  +  +  +  +  +  +  +           +        +        +  +  +|             
      Leukemia Mononuclear                 |                      X                          X                        |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +     +  +  +  +  +  +  +  +  +           +        +        +  +  +|             
      Leukemia Mononuclear                 |       X              X                          X                        |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +     +  +  +  +  +  +  +  +  +           +        +        +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +     +  +  +  +  +  +  +  +  +           +        +        +  +  +|             
      Carcinoma                            |                               X                                          |             
      Fibroadenoma                         |       X                                                           X     X|             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Subcutaneous Tissue, Lipoma          |                      X                                                   |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +     +  +  +  +  +  +  +  +  +           +        +        +  +  +|             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +     +  +  +  +  +  +  +  +  +           +        +        +  +  +|             
      Astrocytoma Malignant                |                                                          X               |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +     +  +  +  +  +  +  +  +  +           +        +        +  +  +|             
      Leukemia Mononuclear                 |                      X                          X                        |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +     +  +  +  +  +  +  +  +  +           +        +        +  +  +|             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +     +  +  +  +  +  +  +  +  +           +        +        +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   9                                                               
NTP Experiment-Test: 05188-05                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                       SODIUM XYLENESULFONATE                                  Date: 09/19/95  
Route: SKIN APPLICATION                                                                                           Time: 20:55:17  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 2| 7| 7| 5| 6| 6| 6| 7| 4| 5| 6| 7| 7| 7| 7| 4| 7| 7| 6| 7| 7| 4| 6| 6|             
                             DAY ON TEST   | 8| 7| 3| 3| 2| 4| 2| 6| 3| 4| 9| 4| 0| 3| 3| 3| 9| 3| 3| 2| 3| 3| 4| 4| 4|             
                                           | 5| 7| 6| 6| 8| 4| 6| 6| 5| 7| 0| 3| 8| 6| 6| 6| 7| 6| 6| 2| 6| 6| 6| 5| 5|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    60 MG/KG                               | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM - cont              |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                                                          +               |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +     +  +  +  +  +  +  +  +  +           +        +        +  +  +|             
      Leukemia Mononuclear                 |                      X                          X                        |             
      Lipoma                               |             X                                                            |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +     +  +  +  +  +  +  +  +  +           +        +        +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SYSTEMIC LESIONS                          |                                                                          |             
                                            __________________________________________________________________________|             
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |       X              X                          X                        |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  10                                                               
NTP Experiment-Test: 05188-05                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                       SODIUM XYLENESULFONATE                                  Date: 09/19/95  
Route: SKIN APPLICATION                                                                                           Time: 20:55:17  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 3| 5| 7| 5| 7| 5| 7| 3| 5| 2| 5| 7| 3| 7| 7| 5| 5| 7| 7| 5| 5| 4| 6| 7| 6|            |
                             DAY ON TEST   | 6| 2| 3| 4| 3| 3| 0| 0| 4| 0| 8| 2| 8| 3| 3| 6| 2| 3| 3| 5| 5| 8| 3| 3| 9|            |
                                           | 7| 5| 6| 7| 6| 7| 1| 1| 1| 1| 2| 2| 6| 6| 6| 3| 8| 6| 6| 9| 0| 6| 0| 6| 4|            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     T      |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3|     A      |
    60 MG/KG                               | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|     L      |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +     +     +  +  +  +  +  +  +  +        +  +        +  +  +  +     +|  35        |
      Periesophageal Tissue, Lipoma        |                                                             X            |          1 |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +     +     +  +  +  +  +  +  +  +        +  +        +  +  +  +     +|  35        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +     +     +  +  +  +  +  +  +  +        +  +        +  +  +  +     +|  35        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +     +     +  +  +  +  +  +  +  +        +  +        +  +  +  +     +|  35        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +     +     +  +  +  +  +  +  +  +        +  +        +  +  +  +     +|  35        |
      Leukemia Mononuclear                 |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +     +     +  +  +  +  +  +  +  +        +  +        +  +  +  +     +|  35        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +     +     +  +  +  +  +  +  +  +        +  +        +  +  +  +     +|  35        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +     +     +  +  +  +  +  +  +  +        +  +        +  +  +  +     +|  35        |
      Leukemia Mononuclear                 |                   X                                                     X|          5 |
                                            __________________________________________________________________________|____________|
   Mesentery                               |                                                                +         |   4        |
      Leukemia Mononuclear                 |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +     +     +  +  +  +  +  +  +  +        +  +        +  +  +  +     +|  35        |
      Leukemia Mononuclear                 |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +     +     +  +  +  +  +  +  +  +        +  +        +  +  +  +     +|  35        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +     +     +  +  +  +  +  +  +  +        +  +        +  +  +  +     +|  35        |
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +     +     +  +  +  +  +  +  +  +        +  +        +  +  +  +     +|  35        |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood Vessel                            | +  +     +     +  +  +  +  +  +  +  +        +  +        +  +  +  +     +|  35        |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +     +     +  +  +  +  +  +  +  +        +  +        +  +  +  +     +|  35        |
      Leukemia Mononuclear                 |                   X                                                      |          2 |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Cortex                          | +  +     +     +  +  +  +  +  +  +  +        +  +        +  +  +  +     +|  35        |
      Adenoma                              |                               X                                          |          1 |
      Leukemia Mononuclear                 |                   X                                                      |          2 |
                                            __________________________________________________________________________|____________|
   Adrenal Medulla                         | +  +     +     +  +  +  +  +  +  +  +        +  +        +  +  +  +     +|  35        |
      Leukemia Mononuclear                 |                   X                                                      |          2 |
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +     +     +  +  +  +  +  +  +  +        +  +        +  +  +  +     +|  35        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +     +     +  +  +  +  +  +  +  +        +  +        +  +  +  +     +|  32        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +     +     +  +  +  +  +  +  +  +        +  +        +  +  +  +     +|  35        |
      Leukemia Mononuclear                 |                   X                                                      |          3 |
      Pars Distalis, Adenoma               |    X     X     X        X                                X  X  X        X|         16 |
      Pars Distalis, Adenoma, Multiple     |                                  X                                       |          1 |
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +     +     +  +  +  +  +  +  +  +        +  +        +  +  +  +     +|  35        |
      C-Cell, Adenoma                      |                                                                          |          1 |
      Follicular Cell, Adenoma             |                                                                          |          2 |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  11                                                               
NTP Experiment-Test: 05188-05                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                       SODIUM XYLENESULFONATE                                  Date: 09/19/95  
Route: SKIN APPLICATION                                                                                           Time: 20:55:17  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 3| 5| 7| 5| 7| 5| 7| 3| 5| 2| 5| 7| 3| 7| 7| 5| 5| 7| 7| 5| 5| 4| 6| 7| 6|            |
                             DAY ON TEST   | 6| 2| 3| 4| 3| 3| 0| 0| 4| 0| 8| 2| 8| 3| 3| 6| 2| 3| 3| 5| 5| 8| 3| 3| 9|            |
                                           | 7| 5| 6| 7| 6| 7| 1| 1| 1| 1| 2| 2| 6| 6| 6| 3| 8| 6| 6| 9| 0| 6| 0| 6| 4|            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     T      |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3|     A      |
    60 MG/KG                               | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|     L      |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 __________________________________________________________________________________________________________________________________ 
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Clitoral Gland                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Adenoma                              |                                                                          |          3 |
                                            __________________________________________________________________________|____________|
   Ovary                                   | +  +     +     +  +  +  +  +  +  +  +        +  +        +  +  +  +     +|  35        |
      Leukemia Mononuclear                 |                   X                                                      |          3 |
                                            __________________________________________________________________________|____________|
   Uterus                                  | +  +     +     +  +  +  +  +  +  +  +        +  +        +  +  +  +     +|  35        |
      Polyp Stromal                        |                                                             X            |          1 |
      Sarcoma Stromal                      |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Vagina                                  |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +     +     +  +  +  +  +  +  +  +        +  +        +  +  +  +     +|  35        |
      Leukemia Mononuclear                 |                   X                                                      |          3 |
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +  +     +        +  +  +     +  +  +        +  +        +  +  +  +     +|  32        |
      Mediastinal, Leukemia Mononuclear    |                   X                                                     X|          3 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +     +     +  +  +  +  +  +  +  +        +  +        +  +  +  +     +|  35        |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +     +     +  +  +  +  +  +  +  +        +  +        +  +  +  +     +|  35        |
      Leukemia Mononuclear                 |                   X                                                      |          3 |
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +     +     +  +  +  +  +  +  +  +        +  +        +  +  +  +     +|  35        |
      Leukemia Mononuclear                 |                   X                                                     X|          5 |
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +     +     +  +  +  +  +  +  +  +        +  +        +  +  +  +     +|  35        |
      Leukemia Mononuclear                 |                   X                                                      |          1 |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  +     +     +  +  +  +  +  +  +  +        +  +        +  +  +  +     +|  35        |
      Carcinoma                            |                                                                          |          1 |
      Fibroadenoma                         |                                                                         X|          4 |
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Subcutaneous Tissue, Lipoma          |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +     +     +  +  +  +  +  +  +  +        +  +        +  +  +  +     +|  35        |
                                            __________________________________________________________________________|____________|
   Skeletal Muscle                         |                            +                                             |   1        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +     +     +  +  +  +  +  +  +  +        +  +        +  +  +  +     +|  35        |
      Astrocytoma Malignant                |                                                                          |          1 |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  12                                                               
NTP Experiment-Test: 05188-05                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                       SODIUM XYLENESULFONATE                                  Date: 09/19/95  
Route: SKIN APPLICATION                                                                                           Time: 20:55:17  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 3| 5| 7| 5| 7| 5| 7| 3| 5| 2| 5| 7| 3| 7| 7| 5| 5| 7| 7| 5| 5| 4| 6| 7| 6|            |
                             DAY ON TEST   | 6| 2| 3| 4| 3| 3| 0| 0| 4| 0| 8| 2| 8| 3| 3| 6| 2| 3| 3| 5| 5| 8| 3| 3| 9|            |
                                           | 7| 5| 6| 7| 6| 7| 1| 1| 1| 1| 2| 2| 6| 6| 6| 3| 8| 6| 6| 9| 0| 6| 0| 6| 4|            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     T      |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3|     A      |
    60 MG/KG                               | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|     L      |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 __________________________________________________________________________________________________________________________________ 
 NERVOUS SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +     +     +  +  +  +  +  +  +  +        +  +        +  +  +  +     +|  35        |
      Leukemia Mononuclear                 |                   X                                                     X|          4 |
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +     +     +  +  +  +  +  +  +  +        +  +        +  +  +  +     +|  35        |
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +     +     +  +  +  +  +  +  +  +        +  +        +  +  +  +     +|  35        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Eye                                     |                                                          +               |   2        |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +     +     +  +  +  +  +  +  +  +        +  +        +  +  +  +     +|  35        |
      Leukemia Mononuclear                 |                   X                                                     X|          4 |
      Lipoma                               |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +     +     +  +  +  +  +  +  +  +        +  +        +  +  +  +     +|  35        |
 __________________________________________________________________________________________________________________________________ 
 SYSTEMIC LESIONS                          |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Leukemia Mononuclear                 |                   X                                                     X|          5 |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  13                                                               
NTP Experiment-Test: 05188-05                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                       SODIUM XYLENESULFONATE                                  Date: 09/19/95  
Route: SKIN APPLICATION                                                                                           Time: 20:55:17  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 6| 7| 7| 7| 5| 5| 7| 6| 6| 5| 5| 7| 7| 7| 6| 5| 7| 7| 5| 6| 7| 5| 7| 7|             
                             DAY ON TEST   | 4| 6| 0| 1| 3| 2| 4| 3| 2| 4| 1| 6| 3| 3| 3| 4| 9| 0| 3| 3| 7| 3| 6| 3| 3|             
                                           | 5| 0| 6| 2| 6| 7| 7| 6| 5| 5| 7| 4| 6| 6| 6| 3| 4| 8| 6| 2| 3| 6| 8| 6| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    120                                    | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
    MG/KG                                  | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +     +  +     +  +  +  +           +  +  +     +  +     +      |             
      Periesophageal Tissue, Lipoma        |                                                 X                        |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +     +  +     +  +  +  +           +  +  +     +  +     +      |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +     +  +     +  +  +  +           +  +  +     +  +     +      |             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +     +  +     +  +  +  +           +  +  +     +  +     +      |             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +     +  +     +  +  +  +           +  +  +     +  +     +      |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +     +  +     +  +  +  +           +  +  +     +  +     +      |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +     +  +     +  +  +  +           +  +  +     +  +     +      |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +     +  +     +  +  +  +           +  +  +     +  +     +      |             
      Leukemia Mononuclear                 |       X  X                 X  X                          X  X            |             
                                            __________________________________________________________________________|             
   Mesentery                               |          +                 +                                      +      |             
      Leukemia Mononuclear                 |          X                                                               |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +     +  +     +  +  +  +           +  +  +     +  +     +      |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +     +  +     +  +  +  +           +  +  +     +  +     +      |             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +     +  +     +  +  +  +           +  +  +     +  +     +      |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +     +  +     +  +  +  +           +  +  +     +  +     +      |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood Vessel                            | +  +  +  +     +  +     +  +  +  +           +  +  +     +  +     +      |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +     +  +     +  +  +  +           +  +  +     +  +     +      |             
      Leukemia Mononuclear                 |                                                          X               |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +     +  +     +  +  +  +           +  +  +     +  +     +      |             
      Leukemia Mononuclear                 |                            X  X                          X  X            |             
                                            __________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +     +  +     +  +  +  +           +  +  +     +  +     +      |             
      Leukemia Mononuclear                 |                                                             X            |             
      Pheochromocytoma Benign              |       X                                                                  |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +     +  +     +  +  +  +           +  +  +     +  +     +      |             
      Adenoma                              |                                                                          |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +     +  +     +  +  +  +           +  +  +     +  +     +      |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +     +  +     +  +  +  +           +  +  +     +  +     +      |             
      Pars Distalis, Adenoma               |    X           X  X     X     X  X           X  X  X     X  X     X      |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +     +  +     +  +  +  +           +  +  +     +  +     +      |             
      C-Cell, Adenoma                      |                                              X                           |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Clitoral Gland                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Adenoma                              |                                     X                                    |             
      Carcinoma                            |                                                                          |             
      Bilateral, Adenoma                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  14                                                               
NTP Experiment-Test: 05188-05                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                       SODIUM XYLENESULFONATE                                  Date: 09/19/95  
Route: SKIN APPLICATION                                                                                           Time: 20:55:17  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 6| 7| 7| 7| 5| 5| 7| 6| 6| 5| 5| 7| 7| 7| 6| 5| 7| 7| 5| 6| 7| 5| 7| 7|             
                             DAY ON TEST   | 4| 6| 0| 1| 3| 2| 4| 3| 2| 4| 1| 6| 3| 3| 3| 4| 9| 0| 3| 3| 7| 3| 6| 3| 3|             
                                           | 5| 0| 6| 2| 6| 7| 7| 6| 5| 5| 7| 4| 6| 6| 6| 3| 4| 8| 6| 2| 3| 6| 8| 6| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    120                                    | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
    MG/KG                                  | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +  +     +  +     +  +  +  +           +  +  +     +  +     +      |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +     +  +     +  +  +  +           +  +  +     +  +     +      |             
      Polyp Stromal                        |                                                                          |             
      Sarcoma Stromal                      |       X                                                                  |             
                                            __________________________________________________________________________|             
   Vagina                                  |    +                                                                     |             
      Squamous Cell Carcinoma              |    X                                                                     |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +     +  +     +  +  +  +           +  +  +     +  +     +      |             
      Leukemia Mononuclear                 |          X                                                               |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +     +  +        +  +  +           +  +  +     +  +     +      |             
      Mediastinal, Leukemia Mononuclear    |       X  X                                               X  X            |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +     +  +     +  +  +  +           +  +  +     +  +     +      |             
      Leukemia Mononuclear                 |          X                                               X  X            |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +     +  +     +  +  +  +           +  +  +     +  +     +      |             
      Leukemia Mononuclear                 |       X  X                                               X  X            |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +     +  +     +  +  +  +           +  +  +     +  +     +      |             
      Leukemia Mononuclear                 |       X  X                 X  X                          X  X            |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  M     +  +     +  +  +  +           +  +  +     +  +     +      |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +     +  +     +  +  +  +           +  +  +     +  +     +      |             
      Fibroadenoma                         |    X     X     X                                   X                     |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Subcutaneous Tissue, Sarcoma         |    X                                                                     |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +     +  +     +  +  +  +           +  +  +     +  +     +      |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +     +  +     +  +  +  +           +  +  +     +  +     +      |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +     +  +     +  +  +  +           +  +  +     +  +     +      |             
      Leukemia Mononuclear                 |       X  X                 X  X                          X  X            |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +     +  +     +  +  +  +           +  +  +     +  +     +      |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +     +  +     +  +  +  +           +  +  +     +  +     +      |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                               +                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +     +  +     +  +  +  +           +  +  +     +  +     +      |             
      Leukemia Mononuclear                 |       X  X                 X  X                          X  X            |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  15                                                               
NTP Experiment-Test: 05188-05                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                       SODIUM XYLENESULFONATE                                  Date: 09/19/95  
Route: SKIN APPLICATION                                                                                           Time: 20:55:17  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 6| 7| 7| 7| 5| 5| 7| 6| 6| 5| 5| 7| 7| 7| 6| 5| 7| 7| 5| 6| 7| 5| 7| 7|             
                             DAY ON TEST   | 4| 6| 0| 1| 3| 2| 4| 3| 2| 4| 1| 6| 3| 3| 3| 4| 9| 0| 3| 3| 7| 3| 6| 3| 3|             
                                           | 5| 0| 6| 2| 6| 7| 7| 6| 5| 5| 7| 4| 6| 6| 6| 3| 4| 8| 6| 2| 3| 6| 8| 6| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    120                                    | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
    MG/KG                                  | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +     +  +     +  +  +  +           +  +  +     +  +     +      |             
 _____________________________________________________________________________________________________________________|             
 SYSTEMIC LESIONS                          |                                                                          |             
                                            __________________________________________________________________________|             
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |       X  X                 X  X                          X  X            |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  16                                                               
NTP Experiment-Test: 05188-05                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                       SODIUM XYLENESULFONATE                                  Date: 09/19/95  
Route: SKIN APPLICATION                                                                                           Time: 20:55:17  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 7| 7| 6| 6| 6| 6| 6| 4| 7| 6| 7| 7| 5| 7| 6| 5| 7| 4| 5| 7| 7| 7| 5| 4|            |
                             DAY ON TEST   | 4| 3| 3| 6| 4| 0| 0| 3| 4| 1| 9| 3| 3| 1| 3| 4| 4| 3| 6| 0| 1| 3| 3| 5| 9|            |
                                           | 4| 6| 6| 6| 8| 3| 2| 8| 1| 7| 7| 6| 6| 0| 6| 6| 2| 6| 2| 1| 2| 6| 6| 9| 2|            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     T      |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|     A      |
    120                                    | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|     L      |
    MG/KG                                  | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +        +  +  +  +  +  +  +  +        +     +  +     +  +  +        +  +|  33        |
      Periesophageal Tissue, Lipoma        |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +        +  +  +  +  +  +  +  +        +     +  +     +  +  +        +  +|  33        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +        +  +  +  +  +  +  +  +        +     +  +     +  +  +        +  +|  33        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +        +  +  +  +  +  +  +  +        +     +  +     +  +  +        +  +|  33        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +        +  +  +  +  +  +  +  +        +     +  +     +  +  +        +  +|  33        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +        +  +  +  +  +  +  +  +        +     +  +     +  +  +        +  +|  33        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +        M  +  +  +  +  +  +  +        +     +  +     +  +  +        +  +|  32        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +        +  +  +  +  +  +  +  +        +     +  +     +  +  +        +  +|  33        |
      Leukemia Mononuclear                 |                X  X        X                                             |          9 |
                                            __________________________________________________________________________|____________|
   Mesentery                               |                                              +                           |   4        |
      Leukemia Mononuclear                 |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Pancreas                                | +        +  +  +  +  +  +  +  +        +     +  +     +  +  +        +  +|  33        |
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +        +  +  +  +  +  +  +  +        +     +  +     +  +  +        +  +|  33        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +        +  +  +  +  +  +  +  +        +     +  +     +  +  +        +  +|  33        |
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +        +  +  +  +  +  +  +  +        +     +  +     +  +  +        +  +|  33        |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood Vessel                            | +        +  +  +  +  +  +  +  +        +     +  +     +  +  +        +  +|  33        |
                                            __________________________________________________________________________|____________|
   Heart                                   | +        +  +  +  +  +  +  +  +        +     +  +     +  +  +        +  +|  33        |
      Leukemia Mononuclear                 |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Cortex                          | +        +  +  +  +  +  +  +  +        +     +  +     +  +  +        +  +|  33        |
      Leukemia Mononuclear                 |                                                                          |          4 |
                                            __________________________________________________________________________|____________|
   Adrenal Medulla                         | +        +  +  +  +  +  +  +  +        +     +  +     +  +  +        +  +|  33        |
      Leukemia Mononuclear                 |                                                                          |          1 |
      Pheochromocytoma Benign              |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +        +  +  +  +  +  +  +  +        +     +  +     +  +  +        +  +|  33        |
      Adenoma                              |                            X                                             |          1 |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +        +  M  +  +  +  +  +  +        M     +  +     +  +  +        +  +|  31        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +        +  +  +  +  +  +  +  +        +     +  +     +  +  +        +  +|  33        |
      Pars Distalis, Adenoma               |          X     X     X  X  X  X                             X            |         19 |
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +        +  +  +  +  +  +  +  +        +     +  +     +  +  +        +  +|  33        |
      C-Cell, Adenoma                      |                                                                      X   |          2 |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  17                                                               
NTP Experiment-Test: 05188-05                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                       SODIUM XYLENESULFONATE                                  Date: 09/19/95  
Route: SKIN APPLICATION                                                                                           Time: 20:55:17  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 7| 7| 6| 6| 6| 6| 6| 4| 7| 6| 7| 7| 5| 7| 6| 5| 7| 4| 5| 7| 7| 7| 5| 4|            |
                             DAY ON TEST   | 4| 3| 3| 6| 4| 0| 0| 3| 4| 1| 9| 3| 3| 1| 3| 4| 4| 3| 6| 0| 1| 3| 3| 5| 9|            |
                                           | 4| 6| 6| 6| 8| 3| 2| 8| 1| 7| 7| 6| 6| 0| 6| 6| 2| 6| 2| 1| 2| 6| 6| 9| 2|            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     T      |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|     A      |
    120                                    | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|     L      |
    MG/KG                                  | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 __________________________________________________________________________________________________________________________________ 
 GENITAL SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Clitoral Gland                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Adenoma                              |                   X                       X                              |          3 |
      Carcinoma                            |                                                                         X|          1 |
      Bilateral, Adenoma                   |                                                             X            |          1 |
                                            __________________________________________________________________________|____________|
   Ovary                                   | +        +  +  +  +  +  +  +  +        +     +  +     +  +  +        +  +|  33        |
                                            __________________________________________________________________________|____________|
   Uterus                                  | +        +  +  +  +  +  +  +  +        +     +  +     +  +  +        +  +|  33        |
      Polyp Stromal                        |                                                                         X|          1 |
      Sarcoma Stromal                      |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Vagina                                  |                                                                          |   1        |
      Squamous Cell Carcinoma              |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +        +  +  +  +  +  +  +  +        +     +  +     +  +  +        +  +|  33        |
      Leukemia Mononuclear                 |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +        +  +           +  +  +        +        +     +  +  +        +   |  27        |
      Mediastinal, Leukemia Mononuclear    |                            X                                             |          5 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +        +  +  +  +  +  +  +  +        +     +  +     +  +  +        +  +|  33        |
      Leukemia Mononuclear                 |                                                                          |          3 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +        +  +  +  +  +  +  +  +        +     +  +     +  +  +        +  +|  33        |
      Leukemia Mononuclear                 |                            X                                             |          5 |
                                            __________________________________________________________________________|____________|
   Spleen                                  | +        +  +  +  +  +  +  +  +        +     +  +     +  +  +        +  +|  33        |
      Leukemia Mononuclear                 |                X  X        X                                             |          9 |
                                            __________________________________________________________________________|____________|
   Thymus                                  | +        +  +  M  +  +  +  +  +        +     +  +     +  +  +        +  +|  31        |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +        +  +  +  +  +  +  +  +        +     +  +     +  +  +        +  +|  33        |
      Fibroadenoma                         |          X           X  X  X                                             |          8 |
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Subcutaneous Tissue, Sarcoma         |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +        +  +  +  +  +  +  +  +        +     +  +     +  +  +        +  +|  33        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +        +  +  +  +  +  +  +  +        +     +  +     +  +  +        +  +|  33        |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    | +        +  +  +  +  +  +  +  +        +     +  +     +  +  +        +  +|  33        |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  18                                                               
NTP Experiment-Test: 05188-05                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                       SODIUM XYLENESULFONATE                                  Date: 09/19/95  
Route: SKIN APPLICATION                                                                                           Time: 20:55:17  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 7| 7| 6| 6| 6| 6| 6| 4| 7| 6| 7| 7| 5| 7| 6| 5| 7| 4| 5| 7| 7| 7| 5| 4|            |
                             DAY ON TEST   | 4| 3| 3| 6| 4| 0| 0| 3| 4| 1| 9| 3| 3| 1| 3| 4| 4| 3| 6| 0| 1| 3| 3| 5| 9|            |
                                           | 4| 6| 6| 6| 8| 3| 2| 8| 1| 7| 7| 6| 6| 0| 6| 6| 2| 6| 2| 1| 2| 6| 6| 9| 2|            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     T      |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|     A      |
    120                                    | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|     L      |
    MG/KG                                  | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 __________________________________________________________________________________________________________________________________ 
 RESPIRATORY SYSTEM - cont                 |                                                                          |            |
                                           |                                                                          |            |
      Leukemia Mononuclear                 |                X           X                                             |          8 |
                                            __________________________________________________________________________|____________|
   Nose                                    | +        +  +  +  +  +  +  +  +        +     +  +     +  +  +        +  +|  33        |
                                            __________________________________________________________________________|____________|
   Trachea                                 | +        +  +  +  +  +  +  +  +        +     +  +     +  +  +        +  +|  33        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Eye                                     |                                                                      +   |   2        |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +        +  +  +  +  +  +  +  +        +     +  +     +  +  +        +  +|  33        |
      Leukemia Mononuclear                 |                X  X        X                                             |          9 |
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +        +  +  +  +  +  +  +  +        +     +  +     +  +  +        +  +|  33        |
 __________________________________________________________________________________________________________________________________ 
 SYSTEMIC LESIONS                          |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Leukemia Mononuclear                 |                X  X        X                                             |          9 |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  19                                                               
NTP Experiment-Test: 05188-05                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                       SODIUM XYLENESULFONATE                                  Date: 09/19/95  
Route: SKIN APPLICATION                                                                                           Time: 20:55:17  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 5| 7| 7| 5| 7| 3| 7| 6| 7| 7| 2| 6| 6| 7| 3| 7| 7| 3| 7| 6| 4| 7| 5| 6|             
                             DAY ON TEST   | 9| 2| 0| 3| 2| 3| 3| 3| 7| 3| 1| 8| 9| 4| 3| 7| 3| 1| 2| 3| 4| 4| 3| 5| 9|             
                                           | 6| 6| 6| 6| 0| 6| 8| 6| 7| 6| 4| 9| 5| 6| 6| 9| 6| 1| 4| 6| 0| 1| 6| 6| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    240                                    | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|             
    MG/KG                                  | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |          X  X  X                       X                 X               |             
                                            __________________________________________________________________________|             
   Mesentery                               |             +  +                                                         |             
      Leukemia Mononuclear                 |                X                                                         |             
                                            __________________________________________________________________________|             
   Oral Mucosa                             |                               +                                          |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Tooth                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood Vessel                            | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                X                                                         |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Adenoma                              |                                                 X                        |             
      Leukemia Mononuclear                 |          X                                                               |             
                                            __________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |          X                                                               |             
      Pheochromocytoma Benign              |                                                                          |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  M  +  +  +  +  +  +  +  +  M  +  +  +  +  M  +  +  +  +  M  +|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |          X     X                                                         |             
      Pars Distalis, Adenoma               | X  X        X              X  X     X     X        X     X        X     X|             
      Pars Distalis, Adenoma, Multiple     |                                                 X                        |             
      Pars Intermedia, Adenoma             |                                                                          |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      C-Cell, Adenoma                      |                X                                   X                    X|             
      C-Cell, Adenoma, Multiple            |                                           X                              |             
      Follicular Cell, Adenoma             |                                                                          |             
      Follicular Cell, Carcinoma           |                         X                                                |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  20                                                               
NTP Experiment-Test: 05188-05                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                       SODIUM XYLENESULFONATE                                  Date: 09/19/95  
Route: SKIN APPLICATION                                                                                           Time: 20:55:17  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 5| 7| 7| 5| 7| 3| 7| 6| 7| 7| 2| 6| 6| 7| 3| 7| 7| 3| 7| 6| 4| 7| 5| 6|             
                             DAY ON TEST   | 9| 2| 0| 3| 2| 3| 3| 3| 7| 3| 1| 8| 9| 4| 3| 7| 3| 1| 2| 3| 4| 4| 3| 5| 9|             
                                           | 6| 6| 6| 6| 0| 6| 8| 6| 7| 6| 4| 9| 5| 6| 6| 9| 6| 1| 4| 6| 0| 1| 6| 6| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    240                                    | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|             
    MG/KG                                  | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Clitoral Gland                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Carcinoma                            |                                                                          |             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
      Mesothelioma Benign                  |                            X                                             |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Polyp Stromal                        |                                           X                              |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |          X  X  X                       X                                 |             
                                            __________________________________________________________________________|             
   Lymph Node                              |       +  +  +  +  +  +     +  +     +        +  +  +  +  +  +  +  +  +  +|             
      Mediastinal, Leukemia Mononuclear    |                X                                                         |             
      Pancreatic, Leukemia Mononuclear     |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                X                                                         |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |          X                                                               |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |          X  X  X                       X                 X               |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M|             
      Leukemia Mononuclear                 |                X                                                         |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Carcinoma                            |                                                                X         |             
      Fibroadenoma                         |       X                    X                    X  X        X            |             
      Fibroadenoma, Multiple               |                                                          X               |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |          X  X  X                       X                 X               |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  21                                                               
NTP Experiment-Test: 05188-05                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                       SODIUM XYLENESULFONATE                                  Date: 09/19/95  
Route: SKIN APPLICATION                                                                                           Time: 20:55:17  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 5| 7| 7| 5| 7| 3| 7| 6| 7| 7| 2| 6| 6| 7| 3| 7| 7| 3| 7| 6| 4| 7| 5| 6|             
                             DAY ON TEST   | 9| 2| 0| 3| 2| 3| 3| 3| 7| 3| 1| 8| 9| 4| 3| 7| 3| 1| 2| 3| 4| 4| 3| 5| 9|             
                                           | 6| 6| 6| 6| 0| 6| 8| 6| 7| 6| 4| 9| 5| 6| 6| 9| 6| 1| 4| 6| 0| 1| 6| 6| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    240                                    | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|             
    MG/KG                                  | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM - cont              |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |       +                                                           +      |             
                                            __________________________________________________________________________|             
   Zymbal's Gland                          |                   +                                                      |             
      Carcinoma                            |                   X                                                      |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |          X  X  X                       X                 X               |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                X                                                         |             
 _____________________________________________________________________________________________________________________|             
 SYSTEMIC LESIONS                          |                                                                          |             
                                            __________________________________________________________________________|             
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |          X  X  X                       X                 X               |             
      Mesothelioma Benign                  |                            X                                             |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  22                                                               
NTP Experiment-Test: 05188-05                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                       SODIUM XYLENESULFONATE                                  Date: 09/19/95  
Route: SKIN APPLICATION                                                                                           Time: 20:55:17  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 7| 7| 4| 7| 7| 3| 5| 7| 6| 5| 7| 5| 6| 6| 7| 6| 3| 6| 7| 5| 6| 7| 6| 6|            |
                             DAY ON TEST   | 7| 3| 3| 1| 3| 3| 9| 9| 3| 1| 8| 3| 1| 5| 7| 3| 3| 9| 1| 2| 0| 3| 3| 3| 5|            |
                                           | 2| 6| 6| 2| 6| 6| 6| 1| 6| 1| 9| 6| 5| 1| 4| 6| 3| 1| 5| 8| 7| 0| 6| 4| 3|            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     T      |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4|     A      |
    240                                    | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|     L      |
    MG/KG                                  | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Leukemia Mononuclear                 |                         X                    X                 X        X|          9 |
                                            __________________________________________________________________________|____________|
   Mesentery                               |                                                       +                 +|   4        |
      Leukemia Mononuclear                 |                                                                         X|          2 |
                                            __________________________________________________________________________|____________|
   Oral Mucosa                             |                         +                                                |   2        |
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Leukemia Mononuclear                 |                                                                         X|          1 |
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Tooth                                   |                         +                                                |   1        |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood Vessel                            | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Leukemia Mononuclear                 |                                                                         X|          2 |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Adenoma                              |                                                                          |          1 |
      Leukemia Mononuclear                 |                                                                X        X|          3 |
                                            __________________________________________________________________________|____________|
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Leukemia Mononuclear                 |                                                                         X|          2 |
      Pheochromocytoma Benign              |    X                                   X                                 |          2 |
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  45        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Leukemia Mononuclear                 |                                                                         X|          3 |
      Pars Distalis, Adenoma               | X  X        X     X  X  X  X  X  X  X  X  X           X  X           X  X|         27 |
      Pars Distalis, Adenoma, Multiple     |                                                                   X      |          2 |
      Pars Intermedia, Adenoma             |                                  X                                       |          1 |
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  23                                                               
NTP Experiment-Test: 05188-05                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                       SODIUM XYLENESULFONATE                                  Date: 09/19/95  
Route: SKIN APPLICATION                                                                                           Time: 20:55:17  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 7| 7| 4| 7| 7| 3| 5| 7| 6| 5| 7| 5| 6| 6| 7| 6| 3| 6| 7| 5| 6| 7| 6| 6|            |
                             DAY ON TEST   | 7| 3| 3| 1| 3| 3| 9| 9| 3| 1| 8| 3| 1| 5| 7| 3| 3| 9| 1| 2| 0| 3| 3| 3| 5|            |
                                           | 2| 6| 6| 2| 6| 6| 6| 1| 6| 1| 9| 6| 5| 1| 4| 6| 3| 1| 5| 8| 7| 0| 6| 4| 3|            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     T      |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4|     A      |
    240                                    | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|     L      |
    MG/KG                                  | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 __________________________________________________________________________________________________________________________________ 
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
                                           |                                                                          |            |
      C-Cell, Adenoma                      |             X           X        X        X                              |          7 |
      C-Cell, Adenoma, Multiple            |                                                                          |          1 |
      Follicular Cell, Adenoma             | X                                                                        |          1 |
      Follicular Cell, Carcinoma           |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Clitoral Gland                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Carcinoma                            |                X           X                                             |          2 |
                                            __________________________________________________________________________|____________|
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Leukemia Mononuclear                 |                                                                         X|          1 |
      Mesothelioma Benign                  |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Polyp Stromal                        |                                                    X              X      |          3 |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  M  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +|  48        |
      Leukemia Mononuclear                 |                                                                         X|          5 |
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  43        |
      Mediastinal, Leukemia Mononuclear    |                                                                X        X|          3 |
      Pancreatic, Leukemia Mononuclear     |                                                                         X|          1 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Leukemia Mononuclear                 |                                                                         X|          2 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +|  48        |
      Leukemia Mononuclear                 |                                                                         X|          2 |
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Leukemia Mononuclear                 |                         X              X     X                 X        X|         10 |
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Leukemia Mononuclear                 |                                                                         X|          2 |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Carcinoma                            |                                                                          |          1 |
      Fibroadenoma                         |                                     X                                    |          6 |
      Fibroadenoma, Multiple               |    X                                                              X      |          3 |
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  24                                                               
NTP Experiment-Test: 05188-05                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                       SODIUM XYLENESULFONATE                                  Date: 09/19/95  
Route: SKIN APPLICATION                                                                                           Time: 20:55:17  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 7| 7| 4| 7| 7| 3| 5| 7| 6| 5| 7| 5| 6| 6| 7| 6| 3| 6| 7| 5| 6| 7| 6| 6|            |
                             DAY ON TEST   | 7| 3| 3| 1| 3| 3| 9| 9| 3| 1| 8| 3| 1| 5| 7| 3| 3| 9| 1| 2| 0| 3| 3| 3| 5|            |
                                           | 2| 6| 6| 2| 6| 6| 6| 1| 6| 1| 9| 6| 5| 1| 4| 6| 3| 1| 5| 8| 7| 0| 6| 4| 3|            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     T      |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4|     A      |
    240                                    | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|     L      |
    MG/KG                                  | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 __________________________________________________________________________________________________________________________________ 
 MUSCULOSKELETAL SYSTEM - cont             |                                                                          |            |
                                           |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  M  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +|  48        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Leukemia Mononuclear                 |                                                                         X|          1 |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Leukemia Mononuclear                 |                                              X                 X        X|          8 |
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Eye                                     |                +                                                  +     +|   5        |
                                            __________________________________________________________________________|____________|
   Zymbal's Gland                          |                                                                          |   1        |
      Carcinoma                            |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Leukemia Mononuclear                 |                         X                                      X        X|          8 |
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Leukemia Mononuclear                 |                                                                         X|          2 |
 __________________________________________________________________________________________________________________________________ 
 SYSTEMIC LESIONS                          |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Leukemia Mononuclear                 |                         X              X     X                 X        X|         10 |
      Mesothelioma Benign                  |                                                                          |          1 |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  25                                                               
NTP Experiment-Test: 05188-05                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                       SODIUM XYLENESULFONATE                                  Date: 09/19/95  
Route: SKIN APPLICATION                                                                                           Time: 20:55:17  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 5| 7| 6| 4| 5| 5| 4| 6| 4| 6| 7| 5| 7| 6| 6| 6| 7| 7| 6| 6| 7| 7| 5| 7|             
                             DAY ON TEST   | 8| 6| 3| 5| 4| 6| 5| 4| 5| 9| 8| 3| 4| 0| 3| 1| 8| 0| 3| 4| 4| 0| 1| 9| 2|             
                                           | 3| 5| 5| 8| 7| 7| 4| 1| 2| 2| 1| 5| 7| 2| 6| 6| 2| 1| 5| 5| 8| 7| 5| 5| 8|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    0 MG/KG                                | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Mesothelioma Malignant, Metastatic,  |                                                                          |             
           Uncertain Primary Site          |    X                                                        X            |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Mesothelioma Malignant, Metastatic,  |                                                                          |             
           Uncertain Primary Site          |    X                                                                     |             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Mesothelioma Malignant, Metastatic,  |                                                                          |             
           Uncertain Primary Site          |    X                                                        X            |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Carcinoma                            |                                                                          |             
      Mesothelioma Malignant, Metastatic,  |                                                                          |             
           Uncertain Primary Site          |                                        X                    X            |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Mesothelioma Malignant, Metastatic,  |                                                                          |             
           Uncertain Primary Site          |    X                                                        X            |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |          X                          X  X     X  X              X         |             
                                            __________________________________________________________________________|             
   Mesentery                               |    +     +                             +     +              +  +         |             
      Leukemia Mononuclear                 |                                              X                           |             
      Mesothelioma Malignant, Metastatic,  |                                                                          |             
           Uncertain Primary Site          |    X                                   X                    X            |             
                                            __________________________________________________________________________|             
   Oral Mucosa                             |                                                                          |             
      Gingival, Squamous Cell Carcinoma    |                                                                          |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Mesothelioma Malignant, Metastatic,  |                                                                          |             
           Uncertain Primary Site          |    X                                   X                    X            |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                              X                           |             
      Mesothelioma Malignant, Metastatic,  |                                                                          |             
           Uncertain Primary Site          |    X                                                        X            |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Mesothelioma Malignant, Metastatic,  |                                                                          |             
           Uncertain Primary Site          |    X                                                        X            |             
                                            __________________________________________________________________________|             
   Tooth                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood Vessel                            | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  26                                                               
NTP Experiment-Test: 05188-05                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                       SODIUM XYLENESULFONATE                                  Date: 09/19/95  
Route: SKIN APPLICATION                                                                                           Time: 20:55:17  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 5| 7| 6| 4| 5| 5| 4| 6| 4| 6| 7| 5| 7| 6| 6| 6| 7| 7| 6| 6| 7| 7| 5| 7|             
                             DAY ON TEST   | 8| 6| 3| 5| 4| 6| 5| 4| 5| 9| 8| 3| 4| 0| 3| 1| 8| 0| 3| 4| 4| 0| 1| 9| 2|             
                                           | 3| 5| 5| 8| 7| 7| 4| 1| 2| 2| 1| 5| 7| 2| 6| 6| 2| 1| 5| 5| 8| 7| 5| 5| 8|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    0 MG/KG                                | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Adenoma                              |                   X                                                      |             
      Leukemia Mononuclear                 |                                     X        X  X                        |             
                                            __________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                     X                                    |             
      Pheochromocytoma Benign              |                   X              X                             X         |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Adenoma                              |                            X                                X     X      |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Adenoma, Multiple                    |             X                                                            |             
      Leukemia Mononuclear                 |                                     X                                    |             
      Pars Distalis, Adenoma               | X  X     X     X     X  X  X  X        X  X  X  X  X     X  X     X  X  X|             
      Pars Distalis, Adenoma, Multiple     |       X           X              X                    X                  |             
      Pars Distalis, Carcinoma             |                                                                          |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Bilateral, C-Cell, Adenoma           |                                        X                                 |             
      C-Cell, Adenoma                      |                                     X           X                        |             
      Follicular Cell, Carcinoma           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Peritoneum                              |    +                                         +              +            |             
      Mesothelioma Malignant, Metastatic,  |                                                                          |             
           Uncertain Primary Site          |    X                                         X              X            |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Mesothelioma Malignant               |                   X                                                      |             
      Mesothelioma Malignant, Metastatic,  |                                                                          |             
           Uncertain Primary Site          |    X                                   X     X              X  X         |             
                                            __________________________________________________________________________|             
   Preputial Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Adenoma                              |                                                                X         |             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                              X                           |             
      Mesothelioma Malignant, Metastatic,  |                                                                          |             
           Uncertain Primary Site          |                                                             X  X         |             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                              X                           |             
      Mesothelioma Malignant, Metastatic,  |                                                                          |             
           Uncertain Primary Site          |    X                                                        X            |             
                                            __________________________________________________________________________|             
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Mesothelioma Malignant, Metastatic,  |                                                                          |             
           Uncertain Primary Site          |    X                                   X     X              X  X         |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  27                                                               
NTP Experiment-Test: 05188-05                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                       SODIUM XYLENESULFONATE                                  Date: 09/19/95  
Route: SKIN APPLICATION                                                                                           Time: 20:55:17  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 5| 7| 6| 4| 5| 5| 4| 6| 4| 6| 7| 5| 7| 6| 6| 6| 7| 7| 6| 6| 7| 7| 5| 7|             
                             DAY ON TEST   | 8| 6| 3| 5| 4| 6| 5| 4| 5| 9| 8| 3| 4| 0| 3| 1| 8| 0| 3| 4| 4| 0| 1| 9| 2|             
                                           | 3| 5| 5| 8| 7| 7| 4| 1| 2| 2| 1| 5| 7| 2| 6| 6| 2| 1| 5| 5| 8| 7| 5| 5| 8|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    0 MG/KG                                | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
      Bilateral, Interstitial Cell, Adenoma|       X                          X  X  X  X                 X  X         |             
      Interstitial Cell, Adenoma           |    X           X                                   X  X  X        X     X|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |          X                          X  X     X  X                        |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +     +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +   |             
      Iliac, Leukemia Mononuclear          |          X                                                               |             
      Mediastinal, Leukemia Mononuclear    |                                              X                 X         |             
      Renal, Leukemia Mononuclear          |                                              X                           |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |          X                             X     X  X              X         |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                              X                 X         |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |          X                          X  X     X  X              X         |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |          X                                                               |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibroadenoma                         |                                                          X               |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Sebaceous Gland, Skin, Site of       |                                                                          |             
          Application, Carcinoma           |                X                                                         |             
      Subcutaneous Tissue, Pinna, Melanoma |                                                                          |             
          Malignant                        |                                                                         X|             
      Subcutaneous Tissue, Skin, Site of   |                                                                          |             
          Application, Fibroma, Multiple   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Astrocytoma Malignant                |                                                                          |             
      Carcinoma, Metastatic, Pituitary     |                                                                          |             
          Gland                            |                                                                          |             
                                            __________________________________________________________________________|             
   Peripheral Nerve                        |                                           +                              |             
                                            __________________________________________________________________________|             
   Spinal Cord                             |                                           +                              |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Alveolar/Bronchiolar Adenoma         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  28                                                               
NTP Experiment-Test: 05188-05                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                       SODIUM XYLENESULFONATE                                  Date: 09/19/95  
Route: SKIN APPLICATION                                                                                           Time: 20:55:17  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 5| 7| 6| 4| 5| 5| 4| 6| 4| 6| 7| 5| 7| 6| 6| 6| 7| 7| 6| 6| 7| 7| 5| 7|             
                             DAY ON TEST   | 8| 6| 3| 5| 4| 6| 5| 4| 5| 9| 8| 3| 4| 0| 3| 1| 8| 0| 3| 4| 4| 0| 1| 9| 2|             
                                           | 3| 5| 5| 8| 7| 7| 4| 1| 2| 2| 1| 5| 7| 2| 6| 6| 2| 1| 5| 5| 8| 7| 5| 5| 8|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    0 MG/KG                                | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
      Alveolar/Bronchiolar Carcinoma       |                                           X                              |             
      Carcinoma, Metastatic, Skin          |                X                                                         |             
      Leukemia Mononuclear                 |          X                          X  X     X  X              X         |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                         +                                                |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Adenoma, Tubular                     |          X                                                               |             
      Leukemia Mononuclear                 |          X                             X     X  X                        |             
      Mesothelioma Malignant, Metastatic,  |                                                                          |             
           Uncertain Primary Site          |    X                                                                     |             
      Renal Tubule, Adenoma                |                                                                          |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Mesothelioma Malignant, Metastatic,  |                                                                          |             
           Uncertain Primary Site          |    X                                   X                    X            |             
      Transitional Epithelium, Papilloma   |                                           X                              |             
 _____________________________________________________________________________________________________________________|             
 SYSTEMIC LESIONS                          |                                                                          |             
                                            __________________________________________________________________________|             
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |          X                          X  X     X  X              X         |             
      Mesothelioma Malignant               |                   X                                                      |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  29                                                               
NTP Experiment-Test: 05188-05                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                       SODIUM XYLENESULFONATE                                  Date: 09/19/95  
Route: SKIN APPLICATION                                                                                           Time: 20:55:17  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 6| 7| 5| 7| 5| 7| 6| 4| 6| 6| 6| 5| 5| 5| 7| 7| 6| 5| 7| 6| 7| 6| 5| 7|            |
                             DAY ON TEST   | 1| 5| 3| 4| 0| 6| 2| 7| 9| 1| 1| 1| 2| 9| 8| 3| 2| 3| 3| 3| 8| 1| 8| 5| 3|            |
                                           | 2| 0| 5| 6| 8| 0| 4| 2| 9| 6| 8| 7| 7| 0| 2| 5| 8| 9| 4| 5| 7| 3| 7| 7| 5|            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     T      |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     A      |
    0 MG/KG                                | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|     L      |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Mesothelioma Malignant, Metastatic,  |                                                                          |            |
           Uncertain Primary Site          |                                                                          |          2 |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Mesothelioma Malignant, Metastatic,  |                                                                          |            |
           Uncertain Primary Site          |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Mesothelioma Malignant, Metastatic,  |                                                                          |            |
           Uncertain Primary Site          |                                                                          |          2 |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Carcinoma                            |                                     X                                    |          1 |
      Mesothelioma Malignant, Metastatic,  |                                                                          |            |
           Uncertain Primary Site          |                                                                          |          2 |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Mesothelioma Malignant, Metastatic,  |                                                                          |            |
           Uncertain Primary Site          |                                                                          |          2 |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Leukemia Mononuclear                 | X           X  X           X                                X           X|         12 |
                                            __________________________________________________________________________|____________|
   Mesentery                               |                +                                            +            |   8        |
      Leukemia Mononuclear                 |                                                                          |          1 |
      Mesothelioma Malignant, Metastatic,  |                                                                          |            |
           Uncertain Primary Site          |                                                                          |          3 |
                                            __________________________________________________________________________|____________|
   Oral Mucosa                             | +        +                                                               |   2        |
      Gingival, Squamous Cell Carcinoma    |          X                                                               |          1 |
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Mesothelioma Malignant, Metastatic,  |                                                                          |            |
           Uncertain Primary Site          |                                                                          |          3 |
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Leukemia Mononuclear                 |                                                                          |          1 |
      Mesothelioma Malignant, Metastatic,  |                                                                          |            |
           Uncertain Primary Site          |                                                                          |          2 |
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Mesothelioma Malignant, Metastatic,  |                                                                          |            |
           Uncertain Primary Site          |                                                                          |          2 |
                                            __________________________________________________________________________|____________|
   Tooth                                   |                   +                                                      |   1        |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  30                                                               
NTP Experiment-Test: 05188-05                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                       SODIUM XYLENESULFONATE                                  Date: 09/19/95  
Route: SKIN APPLICATION                                                                                           Time: 20:55:17  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 6| 7| 5| 7| 5| 7| 6| 4| 6| 6| 6| 5| 5| 5| 7| 7| 6| 5| 7| 6| 7| 6| 5| 7|            |
                             DAY ON TEST   | 1| 5| 3| 4| 0| 6| 2| 7| 9| 1| 1| 1| 2| 9| 8| 3| 2| 3| 3| 3| 8| 1| 8| 5| 3|            |
                                           | 2| 0| 5| 6| 8| 0| 4| 2| 9| 6| 8| 7| 7| 0| 2| 5| 8| 9| 4| 5| 7| 3| 7| 7| 5|            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     T      |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     A      |
    0 MG/KG                                | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|     L      |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 __________________________________________________________________________________________________________________________________ 
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |            |
                                           |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood Vessel                            | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Adenoma                              |                                                                          |          1 |
      Leukemia Mononuclear                 | X                          X                                             |          5 |
                                            __________________________________________________________________________|____________|
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Leukemia Mononuclear                 |                            X                                             |          2 |
      Pheochromocytoma Benign              |    X                 X                          X              X  X      |          8 |
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Adenoma                              |                         X                                   X            |          5 |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  M  M  +  +  +  +  +  +|  46        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Adenoma, Multiple                    |                                                                          |          1 |
      Leukemia Mononuclear                 |                            X                                             |          2 |
      Pars Distalis, Adenoma               | X           X  X  X     X     X  X  X  X  X  X  X  X  X  X           X   |         34 |
      Pars Distalis, Adenoma, Multiple     |    X                 X                                      X     X     X|          9 |
      Pars Distalis, Carcinoma             |          X                                                               |          1 |
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Bilateral, C-Cell, Adenoma           |                                                                          |          1 |
      C-Cell, Adenoma                      |                   X                       X  X  X        X  X            |          8 |
      Follicular Cell, Carcinoma           |             X                                                            |          1 |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Peritoneum                              |                                                                          |   3        |
      Mesothelioma Malignant, Metastatic,  |                                                                          |            |
           Uncertain Primary Site          |                                                                          |          3 |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Mesothelioma Malignant               |                                                                          |          1 |
      Mesothelioma Malignant, Metastatic,  |                                                                          |            |
           Uncertain Primary Site          |                                                                          |          5 |
                                            __________________________________________________________________________|____________|
   Preputial Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Adenoma                              |                                                                          |          1 |
      Leukemia Mononuclear                 | X                                                                        |          1 |
                                            __________________________________________________________________________|____________|
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  31                                                               
NTP Experiment-Test: 05188-05                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                       SODIUM XYLENESULFONATE                                  Date: 09/19/95  
Route: SKIN APPLICATION                                                                                           Time: 20:55:17  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 6| 7| 5| 7| 5| 7| 6| 4| 6| 6| 6| 5| 5| 5| 7| 7| 6| 5| 7| 6| 7| 6| 5| 7|            |
                             DAY ON TEST   | 1| 5| 3| 4| 0| 6| 2| 7| 9| 1| 1| 1| 2| 9| 8| 3| 2| 3| 3| 3| 8| 1| 8| 5| 3|            |
                                           | 2| 0| 5| 6| 8| 0| 4| 2| 9| 6| 8| 7| 7| 0| 2| 5| 8| 9| 4| 5| 7| 3| 7| 7| 5|            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     T      |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     A      |
    0 MG/KG                                | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|     L      |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 __________________________________________________________________________________________________________________________________ 
 GENITAL SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
      Leukemia Mononuclear                 |                                                                          |          1 |
      Mesothelioma Malignant, Metastatic,  |                                                                          |            |
           Uncertain Primary Site          |                                                                          |          2 |
                                            __________________________________________________________________________|____________|
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Leukemia Mononuclear                 |                                                                          |          1 |
      Mesothelioma Malignant, Metastatic,  |                                                                          |            |
           Uncertain Primary Site          |                                                                          |          2 |
                                            __________________________________________________________________________|____________|
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Mesothelioma Malignant, Metastatic,  |                                                                          |            |
           Uncertain Primary Site          |                                                                          |          5 |
      Bilateral, Interstitial Cell, Adenoma|       X                                                  X     X  X      |         11 |
      Interstitial Cell, Adenoma           |             X     X  X     X                          X                 X|         13 |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Leukemia Mononuclear                 | X           X  X           X                                X           X|         11 |
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +  +        +  +        +  +  +  +  +  +  +  +  +     +  +  +  +     +  +|  41        |
      Iliac, Leukemia Mononuclear          |                                                                          |          1 |
      Mediastinal, Leukemia Mononuclear    |             X                                               X            |          4 |
      Renal, Leukemia Mononuclear          |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Leukemia Mononuclear                 |                                                                          |          5 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Leukemia Mononuclear                 |                                                             X            |          3 |
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Leukemia Mononuclear                 | X           X  X           X                                X           X|         12 |
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  M  M  +  +  +|  46        |
      Leukemia Mononuclear                 |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Fibroadenoma                         |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Sebaceous Gland, Skin, Site of       |                                                                          |            |
          Application, Carcinoma           |                                                                          |          1 |
      Subcutaneous Tissue, Pinna, Melanoma |                                                                          |            |
          Malignant                        |                                                                          |          1 |
      Subcutaneous Tissue, Skin, Site of   |                                                                          |            |
          Application, Fibroma, Multiple   |                      X                                                   |          1 |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  32                                                               
NTP Experiment-Test: 05188-05                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                       SODIUM XYLENESULFONATE                                  Date: 09/19/95  
Route: SKIN APPLICATION                                                                                           Time: 20:55:17  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 6| 7| 5| 7| 5| 7| 6| 4| 6| 6| 6| 5| 5| 5| 7| 7| 6| 5| 7| 6| 7| 6| 5| 7|            |
                             DAY ON TEST   | 1| 5| 3| 4| 0| 6| 2| 7| 9| 1| 1| 1| 2| 9| 8| 3| 2| 3| 3| 3| 8| 1| 8| 5| 3|            |
                                           | 2| 0| 5| 6| 8| 0| 4| 2| 9| 6| 8| 7| 7| 0| 2| 5| 8| 9| 4| 5| 7| 3| 7| 7| 5|            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     T      |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     A      |
    0 MG/KG                                | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|     L      |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 __________________________________________________________________________________________________________________________________ 
 INTEGUMENTARY SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Astrocytoma Malignant                |                                                                         X|          1 |
      Carcinoma, Metastatic, Pituitary     |                                                                          |            |
          Gland                            |          X                                                               |          1 |
                                            __________________________________________________________________________|____________|
   Peripheral Nerve                        |                                                                          |   1        |
                                            __________________________________________________________________________|____________|
   Spinal Cord                             |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Alveolar/Bronchiolar Adenoma         |                                  X                                       |          1 |
      Alveolar/Bronchiolar Carcinoma       | X                                                                        |          2 |
      Carcinoma, Metastatic, Skin          |                                                                          |          1 |
      Leukemia Mononuclear                 | X           X  X           X                                X            |         11 |
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Eye                                     |          +                                                           +   |   3        |
                                            __________________________________________________________________________|____________|
   Harderian Gland                         |                                                          +               |   1        |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Adenoma, Tubular                     |                                                                          |          1 |
      Leukemia Mononuclear                 | X           X  X           X                                            X|          9 |
      Mesothelioma Malignant, Metastatic,  |                                                                          |            |
           Uncertain Primary Site          |                                                                          |          1 |
      Renal Tubule, Adenoma                |                                                          X               |          1 |
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Mesothelioma Malignant, Metastatic,  |                                                                          |            |
           Uncertain Primary Site          |                                                                          |          3 |
      Transitional Epithelium, Papilloma   |                                                                          |          1 |
 __________________________________________________________________________________________________________________________________ 
 SYSTEMIC LESIONS                          |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Leukemia Mononuclear                 | X           X  X           X                                X           X|         12 |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  33                                                               
NTP Experiment-Test: 05188-05                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                       SODIUM XYLENESULFONATE                                  Date: 09/19/95  
Route: SKIN APPLICATION                                                                                           Time: 20:55:17  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 6| 7| 5| 7| 5| 7| 6| 4| 6| 6| 6| 5| 5| 5| 7| 7| 6| 5| 7| 6| 7| 6| 5| 7|            |
                             DAY ON TEST   | 1| 5| 3| 4| 0| 6| 2| 7| 9| 1| 1| 1| 2| 9| 8| 3| 2| 3| 3| 3| 8| 1| 8| 5| 3|            |
                                           | 2| 0| 5| 6| 8| 0| 4| 2| 9| 6| 8| 7| 7| 0| 2| 5| 8| 9| 4| 5| 7| 3| 7| 7| 5|            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     T      |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     A      |
    0 MG/KG                                | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|     L      |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 __________________________________________________________________________________________________________________________________ 
 SYSTEMIC LESIONS - cont                   |                                                                          |            |
                                           |                                                                          |            |
      Mesothelioma Malignant               |                                                                          |          1 |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  34                                                               
NTP Experiment-Test: 05188-05                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                       SODIUM XYLENESULFONATE                                  Date: 09/19/95  
Route: SKIN APPLICATION                                                                                           Time: 20:55:17  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 6| 5| 6| 4| 5| 7| 7| 7| 6| 7| 7| 7| 6| 5| 7| 7| 1| 5| 7| 4| 7| 7| 6|             
                             DAY ON TEST   | 0| 3| 4| 4| 3| 9| 4| 0| 3| 2| 1| 3| 3| 3| 4| 6| 3| 3| 9| 1| 3| 4| 3| 3| 5|             
                                           | 9| 5| 5| 7| 1| 1| 1| 2| 5| 6| 9| 5| 5| 5| 3| 5| 5| 5| 6| 6| 2| 1| 5| 5| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    60 MG/KG                               | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +     +  +  +  +  +  +     +  +           +  +        +  +  +  +        +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +     +  +  +  +  +  +     +  +           +  +        +  +  +  +        +|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +     +  +  +  +  +  +     +  +           +  +        +  +  +  +        +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +     +  +  +  +  +  +     +  +           +  +        +  +  +  +        +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +     +  +  +  +  +  +     +  +           +  +        +  +  +  +        +|             
      Mesothelioma Malignant, Metastatic,  |                                                                          |             
           Uncertain Primary Site          |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +     +  +  +  +  +  +     +  +           +  +        +  +  +  +        +|             
      Leiomyosarcoma                       |                   X                                                      |             
      Mesothelioma Malignant, Metastatic,  |                                                                          |             
           Uncertain Primary Site          |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +     +  +  +  +  +  +     +  +           +  +        +  +  +  +        +|             
      Mesothelioma Malignant, Metastatic,  |                                                                          |             
           Uncertain Primary Site          |                                                                          |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +     +  +  +  +  +  +  +|             
      Carcinoma, Metastatic, Kidney        |                                                                         X|             
      Hepatocellular Carcinoma             |                      X                                                   |             
      Leiomyosarcoma, Metastatic,          |                                                                          |             
          Intestine Small, Jejunum         |                   X                                                      |             
      Leukemia Mononuclear                 |    X  X        X     X  X        X  X           X           X     X  X   |             
                                            __________________________________________________________________________|             
   Mesentery                               |             +     +        +                                            +|             
      Carcinoma, Metastatic, Kidney        |                                                                         X|             
      Leiomyosarcoma, Metastatic,          |                                                                          |             
          Intestine Small, Jejunum         |                   X                                                      |             
      Leukemia Mononuclear                 |                                                                          |             
      Mesothelioma Malignant, Metastatic,  |                                                                          |             
           Uncertain Primary Site          |                                                                          |             
                                            __________________________________________________________________________|             
   Oral Mucosa                             |                                                                          |             
                                            __________________________________________________________________________|             
   Pancreas                                | +     +  +  +  +  +  +     +  +           +  +        +  +  +  +        +|             
      Carcinoma, Metastatic, Kidney        |                                                                         X|             
      Leiomyosarcoma, Metastatic,          |                                                                          |             
          Intestine Small, Jejunum         |                   X                                                      |             
      Leukemia Mononuclear                 |                                                                          |             
      Mesothelioma Malignant, Metastatic,  |                                                                          |             
           Uncertain Primary Site          |                                                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +     +  +  +  +  +  +     +  +           +  +        +  +  +  +        +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +     +  +  +  +  +  +     +  +           +  +        +  +  +  +        +|             
      Mesothelioma Malignant, Metastatic,  |                                                                          |             
           Uncertain Primary Site          |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +     +  +  +  +  +  +     +  +           +  +        +  +  +  +        +|             
      Mesothelioma Malignant, Metastatic,  |                                                                          |             
           Uncertain Primary Site          |                                                                          |             
                                            __________________________________________________________________________|             
   Tongue                                  |       +                                                                  |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  35                                                               
NTP Experiment-Test: 05188-05                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                       SODIUM XYLENESULFONATE                                  Date: 09/19/95  
Route: SKIN APPLICATION                                                                                           Time: 20:55:17  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 6| 5| 6| 4| 5| 7| 7| 7| 6| 7| 7| 7| 6| 5| 7| 7| 1| 5| 7| 4| 7| 7| 6|             
                             DAY ON TEST   | 0| 3| 4| 4| 3| 9| 4| 0| 3| 2| 1| 3| 3| 3| 4| 6| 3| 3| 9| 1| 3| 4| 3| 3| 5|             
                                           | 9| 5| 5| 7| 1| 1| 1| 2| 5| 6| 9| 5| 5| 5| 3| 5| 5| 5| 6| 6| 2| 1| 5| 5| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    60 MG/KG                               | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |             
                                           |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood Vessel                            | +     +  +  +  +  +  +     +  +           +  +        +  +  +  +        +|             
                                            __________________________________________________________________________|             
   Heart                                   | +     +  +  +  +  +  +     +  +           +  +        +  +  +  +        +|             
      Leukemia Mononuclear                 |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Cortex                          | +     +  +  +  +  +  +     +  +           +  +        +  +  +  +        +|             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Medulla                         | +     +  +  +  +  +  +     +  +           +  +        +  +  +  +        +|             
      Leukemia Mononuclear                 |                                                                          |             
      Pheochromocytoma Benign              |                      X                                      X            |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +     +  +  +  +  +  +     +  +           +  +        +  +  +  +        +|             
      Carcinoma                            |                            X                                             |             
      Carcinoma, Metastatic, Kidney        |                                                                         X|             
      Leiomyosarcoma, Metastatic,          |                                                                          |             
          Intestine Small, Jejunum         |                   X                                                      |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +     M  +  +  +  M  +     +  +           +  +        +  +  +  +        +|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +     +  +  +  +  +  +     +  +           +  +        +  +  +  +        +|             
      Leukemia Mononuclear                 |                                                                          |             
      Pars Distalis, Adenoma               | X     X  X  X     X  X     X  X           X  X           X  X  X         |             
      Pars Distalis, Adenoma, Multiple     |                                                                          |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +     +  +  +  +  +  +     +  +           +  +        +  +  +  +        +|             
      C-Cell, Adenoma                      |             X     X                       X                              |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Peritoneum                              |                                                                          |             
      Mesothelioma Malignant, Metastatic,  |                                                                          |             
           Uncertain Primary Site          |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              | +     +  +  +  +  +  +     +  +           +  +        +  +  +  +        +|             
      Mesothelioma Malignant, Metastatic,  |                                                                          |             
           Uncertain Primary Site          |                                                                          |             
                                            __________________________________________________________________________|             
   Preputial Gland                         | +     +  +  +  +  +  +     +  +           +  +        +  +  +  +        +|             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Prostate                                | +     +  +  +  +  +  +     +  +           +  +        +  +  +  +        +|             
      Leukemia Mononuclear                 |                                                                          |             
      Mesothelioma Malignant, Metastatic,  |                                                                          |             
           Uncertain Primary Site          |                                                                          |             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         | +     +  +  +  +  +  +     +  +           +  +        +  +  +  +        +|             
      Carcinoma, Metastatic, Kidney        |                                                                         X|             
      Leiomyosarcoma, Metastatic,          |                                                                          |             
          Intestine Small, Jejunum         |                   X                                                      |             
      Leukemia Mononuclear                 |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  36                                                               
NTP Experiment-Test: 05188-05                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                       SODIUM XYLENESULFONATE                                  Date: 09/19/95  
Route: SKIN APPLICATION                                                                                           Time: 20:55:17  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 6| 5| 6| 4| 5| 7| 7| 7| 6| 7| 7| 7| 6| 5| 7| 7| 1| 5| 7| 4| 7| 7| 6|             
                             DAY ON TEST   | 0| 3| 4| 4| 3| 9| 4| 0| 3| 2| 1| 3| 3| 3| 4| 6| 3| 3| 9| 1| 3| 4| 3| 3| 5|             
                                           | 9| 5| 5| 7| 1| 1| 1| 2| 5| 6| 9| 5| 5| 5| 3| 5| 5| 5| 6| 6| 2| 1| 5| 5| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    60 MG/KG                               | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
      Mesothelioma Malignant, Metastatic,  |                                                                          |             
           Uncertain Primary Site          |                                                                          |             
                                            __________________________________________________________________________|             
   Testes                                  | +     +  +  +  +  +  +     +  +           +  +        +  +  +  +        +|             
      Mesothelioma Malignant, Metastatic,  |                                                                          |             
           Uncertain Primary Site          |                                                                          |             
      Bilateral, Interstitial Cell, Adenoma|                            X              X                              |             
      Interstitial Cell, Adenoma           |                   X                                         X           X|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | M     +  +  +  +  +  +     +  +           +  +        +  +  +  +        +|             
      Leukemia Mononuclear                 |                X     X                                                   |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +     +  +  +     +  +     +  +              +        +        +        +|             
      Leukemia Mononuclear                 |                                                                          |             
      Deep Cervical, Leukemia Mononuclear  |                                                                          |             
      Inguinal, Leukemia Mononuclear       |                                                                          |             
      Lumbar, Leukemia Mononuclear         |                                                                          |             
      Mediastinal, Carcinoma, Metastatic,  |                                                                          |             
           Kidney                          |                                                                         X|             
      Mediastinal, Leukemia Mononuclear    |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +     +  +  +  +  +  +     +  +           +  +        +  +  +  +        +|             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +     +  +  +  +  +  +     +  +           +  +        +  +  +  +        +|             
      Carcinoma, Metastatic, Kidney        |                                                                         X|             
      Leiomyosarcoma, Metastatic,          |                                                                          |             
          Intestine Small, Jejunum         |                   X                                                      |             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +|             
      Fibroma                              |                                                                   X      |             
      Leukemia Mononuclear                 |    X  X        X     X  X     X  X  X  X        X           X     X  X   |             
                                            __________________________________________________________________________|             
   Thymus                                  | +     +  +  +  M  +  +     +  +           +  M        +  +  +  +        +|             
      Leukemia Mononuclear                 |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +     +  +  +  +  M  +     +  +           +  +        +  +  +  +        +|             
      Carcinoma                            |                                                             X            |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Keratoacanthoma                      |                                                                          |             
      Skin, Site of Application, Basal     |                                                                          |             
          Cell Adenoma                     |                                                             X            |             
      Subcutaneous Tissue, Fibroma         |             X                                                            |             
      Subcutaneous Tissue, Skin, Site of   |                                                                          |             
          Application, Fibrous Histiocytoma|                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  37                                                               
NTP Experiment-Test: 05188-05                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                       SODIUM XYLENESULFONATE                                  Date: 09/19/95  
Route: SKIN APPLICATION                                                                                           Time: 20:55:17  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 6| 5| 6| 4| 5| 7| 7| 7| 6| 7| 7| 7| 6| 5| 7| 7| 1| 5| 7| 4| 7| 7| 6|             
                             DAY ON TEST   | 0| 3| 4| 4| 3| 9| 4| 0| 3| 2| 1| 3| 3| 3| 4| 6| 3| 3| 9| 1| 3| 4| 3| 3| 5|             
                                           | 9| 5| 5| 7| 1| 1| 1| 2| 5| 6| 9| 5| 5| 5| 3| 5| 5| 5| 6| 6| 2| 1| 5| 5| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    60 MG/KG                               | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM - cont             |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | M     +  +  +  +  +  +     +  +           +  +        +  +  +  +        +|             
      Rib, Osteosarcoma                    |                                                                          |             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |                   +                                                     +|             
      Carcinoma, Metastatic, Kidney        |                                                                         X|             
      Leiomyosarcoma, Metastatic,          |                                                                          |             
          Intestine Small, Jejunum         |                   X                                                      |             
      Osteosarcoma, Metastatic, Bone       |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +     +  +  +  +  +  +     +  +           +  +        +  +  +  +        +|             
      Astrocytoma Malignant                |                                                                          |             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Peripheral Nerve                        |                                              +                           |             
                                            __________________________________________________________________________|             
   Spinal Cord                             |                                              +                           |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +     +  +  +  +  +  +     +  +           +  +        +  +  +  +        +|             
      Carcinoma, Metastatic, Kidney        |                                                                         X|             
      Leiomyosarcoma, Metastatic,          |                                                                          |             
          Intestine Small, Jejunum         |                   X                                                      |             
      Leukemia Mononuclear                 |       X              X                                      X            |             
      Mediastinum, Osteosarcoma,           |                                                                          |             
          Metastatic, Bone                 |                                                                          |             
                                            __________________________________________________________________________|             
   Nose                                    | M     +  +  +  +  +  +     +  +           +  +        +  +  +  +        +|             
                                            __________________________________________________________________________|             
   Trachea                                 | +     +  +  +  +  +  +     +  +           +  +        +  +  +  +        +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                                                          +               |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                                                       +                  |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +     +  +  +  +  +  +     +  +           +  +        +  +  +  +        +|             
      Carcinoma, Metastatic, Kidney        |                                                                         X|             
      Leukemia Mononuclear                 |       X              X                                      X            |             
      Sarcoma                              |                X                                                         |             
      Renal Tubule, Carcinoma              |                                                                         X|             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +     +  +  +  +  +  +     +  +           +  +        +  +  +  +        +|             
      Leukemia Mononuclear                 |                                                                          |             
      Mesothelioma Malignant, Metastatic,  |                                                                          |             
           Uncertain Primary Site          |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 SYSTEMIC LESIONS                          |                                                                          |             
                                            __________________________________________________________________________|             
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |    X  X        X     X  X     X  X  X  X        X           X     X  X   |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  38                                                               
NTP Experiment-Test: 05188-05                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                       SODIUM XYLENESULFONATE                                  Date: 09/19/95  
Route: SKIN APPLICATION                                                                                           Time: 20:55:17  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 6| 7| 7| 6| 7| 6| 6| 6| 3| 5| 6| 7| 7| 5| 7| 6| 7| 7| 3| 6| 6| 3| 7|            |
                             DAY ON TEST   | 3| 3| 3| 3| 1| 5| 3| 4| 0| 2| 6| 2| 0| 3| 0| 4| 3| 0| 3| 3| 9| 7| 0| 4| 0|            |
                                           | 5| 5| 1| 5| 0| 8| 5| 5| 3| 3| 2| 7| 9| 5| 2| 0| 5| 1| 5| 5| 3| 4| 3| 9| 2|            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     T      |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1|     A      |
    60 MG/KG                               | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|     L      |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               |       +     +  +     +  +  +  +  +  +     +  +     +        +  +  +  +  +|  33        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  |       +     +  +     +  +  +  +  +  +     +  +     +        +  +  +  +  +|  33        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 |       +     +  +     +  +  +  +  +  +     +  +     +        +  +  +  +  +|  33        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  |       +     +  +     +  +  +  +  +  +     +  +     +        +  +  +  +  +|  33        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               |       +     +  +     +  +  +  +  +  +     +  +     +        +  +  +  +  +|  33        |
      Mesothelioma Malignant, Metastatic,  |                                                                          |            |
           Uncertain Primary Site          |                                                                X         |          1 |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                |       +     +  +     +  +  +  +  +  +     +  +     +        +  +  +  +  +|  33        |
      Leiomyosarcoma                       |                                                                          |          1 |
      Mesothelioma Malignant, Metastatic,  |                                                                          |            |
           Uncertain Primary Site          |                                                                X         |          1 |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  |       +     +  +     +  +  +  +  +  +     +  +     +        +  +  +  +  +|  33        |
      Mesothelioma Malignant, Metastatic,  |                                                                          |            |
           Uncertain Primary Site          |                                                                X         |          1 |
                                            __________________________________________________________________________|____________|
   Liver                                   |       +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +|  45        |
      Carcinoma, Metastatic, Kidney        |                                                                          |          1 |
      Hepatocellular Carcinoma             |                                                                          |          1 |
      Leiomyosarcoma, Metastatic,          |                                                                          |            |
          Intestine Small, Jejunum         |                                                                          |          1 |
      Leukemia Mononuclear                 |       X  X     X  X     X  X     X     X        X  X  X                  |         22 |
                                            __________________________________________________________________________|____________|
   Mesentery                               |                                  +  +                          +         |   7        |
      Carcinoma, Metastatic, Kidney        |                                                                          |          1 |
      Leiomyosarcoma, Metastatic,          |                                                                          |            |
          Intestine Small, Jejunum         |                                                                          |          1 |
      Leukemia Mononuclear                 |                                  X                                       |          1 |
      Mesothelioma Malignant, Metastatic,  |                                                                          |            |
           Uncertain Primary Site          |                                                                X         |          1 |
                                            __________________________________________________________________________|____________|
   Oral Mucosa                             |                                                                +         |   1        |
                                            __________________________________________________________________________|____________|
   Pancreas                                |       +     +  +     +  +  +  +  +  +     +  +     +        +  +  +  +  +|  33        |
      Carcinoma, Metastatic, Kidney        |                                                                          |          1 |
      Leiomyosarcoma, Metastatic,          |                                                                          |            |
          Intestine Small, Jejunum         |                                                                          |          1 |
      Leukemia Mononuclear                 |                                  X                                       |          1 |
      Mesothelioma Malignant, Metastatic,  |                                                                          |            |
           Uncertain Primary Site          |                                                                X         |          1 |
                                            __________________________________________________________________________|____________|
   Salivary Glands                         |       +     +  +     +  +  +  +  +  +     +  +     +        +  +  +  +  +|  33        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    |       +     +  +     +  +  +  +  +  +     +  +     +        +  +  +  +  +|  33        |
      Mesothelioma Malignant, Metastatic,  |                                                                          |            |
           Uncertain Primary Site          |                                                                X         |          1 |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  39                                                               
NTP Experiment-Test: 05188-05                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                       SODIUM XYLENESULFONATE                                  Date: 09/19/95  
Route: SKIN APPLICATION                                                                                           Time: 20:55:17  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 6| 7| 7| 6| 7| 6| 6| 6| 3| 5| 6| 7| 7| 5| 7| 6| 7| 7| 3| 6| 6| 3| 7|            |
                             DAY ON TEST   | 3| 3| 3| 3| 1| 5| 3| 4| 0| 2| 6| 2| 0| 3| 0| 4| 3| 0| 3| 3| 9| 7| 0| 4| 0|            |
                                           | 5| 5| 1| 5| 0| 8| 5| 5| 3| 3| 2| 7| 9| 5| 2| 0| 5| 1| 5| 5| 3| 4| 3| 9| 2|            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     T      |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1|     A      |
    60 MG/KG                               | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|     L      |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      |       +     +  +     +  +  +  +  +  +     +  +     +        +  +  +  +  +|  33        |
      Mesothelioma Malignant, Metastatic,  |                                                                          |            |
           Uncertain Primary Site          |                                                                X         |          1 |
                                            __________________________________________________________________________|____________|
   Tongue                                  |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood Vessel                            |       +     +  +     +  +  +  +  +  +     +  +     +        +  +  +  +  +|  33        |
                                            __________________________________________________________________________|____________|
   Heart                                   |       +     +  +     +  +  +  +  +  +     +  +     +        +  +  +  +  +|  33        |
      Leukemia Mononuclear                 |       X                          X                 X                     |          3 |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Cortex                          |       +     +  +     +  +  +  +  +  +     +  +     +        +  +  +  +  +|  33        |
      Leukemia Mononuclear                 |                                  X                 X                     |          2 |
                                            __________________________________________________________________________|____________|
   Adrenal Medulla                         |       +     +  +     +  +  +  +  +  +     +  +     +        +  +  +  +  +|  33        |
      Leukemia Mononuclear                 |                                                    X                     |          1 |
      Pheochromocytoma Benign              |             X              X                                   X         |          5 |
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      |       +     +  +     +  +  +  +  +  +     +  +     +        +  +  +  +  +|  33        |
      Carcinoma                            |                                                                          |          1 |
      Carcinoma, Metastatic, Kidney        |                                                                          |          1 |
      Leiomyosarcoma, Metastatic,          |                                                                          |            |
          Intestine Small, Jejunum         |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       |       +     +  +     +  +  +  M  +  +     +  +     +        +  +  +  +  M|  29        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         |       +     +  +     +  +  +  +  +  +     +  +     +        +  +  +  +  +|  33        |
      Leukemia Mononuclear                 |                                                    X                     |          1 |
      Pars Distalis, Adenoma               |             X  X     X  X  X  X     X        X              X  X  X  X  X|         26 |
      Pars Distalis, Adenoma, Multiple     |                                           X                              |          1 |
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           |       +     +  +     +  +  +  +  +  +     +  +     +        +  +  +  +  +|  33        |
      C-Cell, Adenoma                      |                                                                          |          3 |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Peritoneum                              |                                                                +         |   1        |
      Mesothelioma Malignant, Metastatic,  |                                                                          |            |
           Uncertain Primary Site          |                                                                X         |          1 |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Epididymis                              |       +     +  +     +  +  +  +  +  +     +  +     +        +  +  +  +  +|  33        |
      Mesothelioma Malignant, Metastatic,  |                                                                          |            |
           Uncertain Primary Site          |                                                                X         |          1 |
                                            __________________________________________________________________________|____________|
   Preputial Gland                         |       +     +  +     +  +  +  +  +  +     +  +     +        +  +  +  +  +|  33        |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  40                                                               
NTP Experiment-Test: 05188-05                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                       SODIUM XYLENESULFONATE                                  Date: 09/19/95  
Route: SKIN APPLICATION                                                                                           Time: 20:55:17  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 6| 7| 7| 6| 7| 6| 6| 6| 3| 5| 6| 7| 7| 5| 7| 6| 7| 7| 3| 6| 6| 3| 7|            |
                             DAY ON TEST   | 3| 3| 3| 3| 1| 5| 3| 4| 0| 2| 6| 2| 0| 3| 0| 4| 3| 0| 3| 3| 9| 7| 0| 4| 0|            |
                                           | 5| 5| 1| 5| 0| 8| 5| 5| 3| 3| 2| 7| 9| 5| 2| 0| 5| 1| 5| 5| 3| 4| 3| 9| 2|            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     T      |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1|     A      |
    60 MG/KG                               | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|     L      |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 __________________________________________________________________________________________________________________________________ 
 GENITAL SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
      Leukemia Mononuclear                 |                            X     X                                       |          2 |
                                            __________________________________________________________________________|____________|
   Prostate                                |       +     +  +     +  +  +  +  +  +     +  +     +        +  +  +  +  +|  33        |
      Leukemia Mononuclear                 |                                  X                                       |          1 |
      Mesothelioma Malignant, Metastatic,  |                                                                          |            |
           Uncertain Primary Site          |                                                                X         |          1 |
                                            __________________________________________________________________________|____________|
   Seminal Vesicle                         |       +     +  +     +  +  +  +  +  +     +  +     +        +  +  +  +  +|  33        |
      Carcinoma, Metastatic, Kidney        |                                                                          |          1 |
      Leiomyosarcoma, Metastatic,          |                                                                          |            |
          Intestine Small, Jejunum         |                                                                          |          1 |
      Leukemia Mononuclear                 |                            X     X                                       |          2 |
      Mesothelioma Malignant, Metastatic,  |                                                                          |            |
           Uncertain Primary Site          |                                                                X         |          1 |
                                            __________________________________________________________________________|____________|
   Testes                                  |       +     +  +     +  +  +  +  +  +     +  +     +        +  +  +  +  +|  33        |
      Mesothelioma Malignant, Metastatic,  |                                                                          |            |
           Uncertain Primary Site          |                                                                X         |          1 |
      Bilateral, Interstitial Cell, Adenoma|                                                                          |          2 |
      Interstitial Cell, Adenoma           |             X        X              X                                    |          6 |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             |       +     +  +     +  +  +  +  +  +     +  +     +        +  +  +  +  +|  32        |
      Leukemia Mononuclear                 |                         X        X                 X                     |          5 |
                                            __________________________________________________________________________|____________|
   Lymph Node                              |       +     +  +        +  +  +  +  +     +  +                 +  +     +|  25        |
      Leukemia Mononuclear                 |                                  X                                       |          1 |
      Deep Cervical, Leukemia Mononuclear  |                                  X                                       |          1 |
      Inguinal, Leukemia Mononuclear       |                                  X                                       |          1 |
      Lumbar, Leukemia Mononuclear         |                                  X                                       |          1 |
      Mediastinal, Carcinoma, Metastatic,  |                                                                          |            |
           Kidney                          |                                                                          |          1 |
      Mediastinal, Leukemia Mononuclear    |                         X        X                                       |          2 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  |       +     +  +     +  +  +  +  +  +     +  +     +        +  +  +  +  +|  33        |
      Leukemia Mononuclear                 |                                  X                                       |          1 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  |       +     +  +     +  +  +  +  +  +     +  +     +        +  +  +  +  +|  33        |
      Carcinoma, Metastatic, Kidney        |                                                                          |          1 |
      Leiomyosarcoma, Metastatic,          |                                                                          |            |
          Intestine Small, Jejunum         |                                                                          |          1 |
      Leukemia Mononuclear                 |                                  X                                       |          1 |
                                            __________________________________________________________________________|____________|
   Spleen                                  |       +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +|  46        |
      Fibroma                              |                                                                          |          1 |
      Leukemia Mononuclear                 |       X  X     X  X     X  X     X     X        X  X  X                  |         24 |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  41                                                               
NTP Experiment-Test: 05188-05                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                       SODIUM XYLENESULFONATE                                  Date: 09/19/95  
Route: SKIN APPLICATION                                                                                           Time: 20:55:17  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 6| 7| 7| 6| 7| 6| 6| 6| 3| 5| 6| 7| 7| 5| 7| 6| 7| 7| 3| 6| 6| 3| 7|            |
                             DAY ON TEST   | 3| 3| 3| 3| 1| 5| 3| 4| 0| 2| 6| 2| 0| 3| 0| 4| 3| 0| 3| 3| 9| 7| 0| 4| 0|            |
                                           | 5| 5| 1| 5| 0| 8| 5| 5| 3| 3| 2| 7| 9| 5| 2| 0| 5| 1| 5| 5| 3| 4| 3| 9| 2|            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     T      |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1|     A      |
    60 MG/KG                               | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|     L      |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Thymus                                  |       +     +  +     +  +  +  +  +  +     +  +     +        +  +  +  +  +|  31        |
      Leukemia Mononuclear                 |                                  X                                       |          1 |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           |       +     +  +     +  +  +  +  +  +     +  +     +        +  +  +  +  +|  32        |
      Carcinoma                            |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Keratoacanthoma                      |                X                                                         |          1 |
      Skin, Site of Application, Basal     |                                                                          |            |
          Cell Adenoma                     |                                                                          |          1 |
      Subcutaneous Tissue, Fibroma         |                                                                          |          1 |
      Subcutaneous Tissue, Skin, Site of   |                                                                          |            |
          Application, Fibrous Histiocytoma|                X                                                         |          1 |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    |       +     +  +     +  +  +  +  +  +     +  +     +        +  +  +  +  +|  32        |
      Rib, Osteosarcoma                    |             X                                                            |          1 |
                                            __________________________________________________________________________|____________|
   Skeletal Muscle                         |             +                                                            |   3        |
      Carcinoma, Metastatic, Kidney        |                                                                          |          1 |
      Leiomyosarcoma, Metastatic,          |                                                                          |            |
          Intestine Small, Jejunum         |                                                                          |          1 |
      Osteosarcoma, Metastatic, Bone       |             X                                                            |          1 |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   |       +     +  +     +  +  +  +  +  +     +  +     +        +  +  +  +  +|  33        |
      Astrocytoma Malignant                |             X                                                            |          1 |
      Leukemia Mononuclear                 |                                                    X                     |          1 |
                                            __________________________________________________________________________|____________|
   Peripheral Nerve                        |                                                                          |   1        |
                                            __________________________________________________________________________|____________|
   Spinal Cord                             |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    |       +     +  +     +  +  +  +  +  +     +  +     +        +  +  +  +  +|  33        |
      Carcinoma, Metastatic, Kidney        |                                                                          |          1 |
      Leiomyosarcoma, Metastatic,          |                                                                          |            |
          Intestine Small, Jejunum         |                                                                          |          1 |
      Leukemia Mononuclear                 |       X        X        X  X     X                 X                     |          9 |
      Mediastinum, Osteosarcoma,           |                                                                          |            |
          Metastatic, Bone                 |             X                                                            |          1 |
                                            __________________________________________________________________________|____________|
   Nose                                    |       +     +  +     +  +  +  +  +  +     +  +     +        +  +  +  +  +|  32        |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  42                                                               
NTP Experiment-Test: 05188-05                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                       SODIUM XYLENESULFONATE                                  Date: 09/19/95  
Route: SKIN APPLICATION                                                                                           Time: 20:55:17  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 6| 7| 7| 6| 7| 6| 6| 6| 3| 5| 6| 7| 7| 5| 7| 6| 7| 7| 3| 6| 6| 3| 7|            |
                             DAY ON TEST   | 3| 3| 3| 3| 1| 5| 3| 4| 0| 2| 6| 2| 0| 3| 0| 4| 3| 0| 3| 3| 9| 7| 0| 4| 0|            |
                                           | 5| 5| 1| 5| 0| 8| 5| 5| 3| 3| 2| 7| 9| 5| 2| 0| 5| 1| 5| 5| 3| 4| 3| 9| 2|            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     T      |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1|     A      |
    60 MG/KG                               | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|     L      |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 __________________________________________________________________________________________________________________________________ 
 RESPIRATORY SYSTEM - cont                 |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Trachea                                 |       +     +  +     +  +  +  +  +  +     +  +     +        +  +  +  +  +|  33        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Eye                                     |                      +                                                   |   2        |
                                            __________________________________________________________________________|____________|
   Harderian Gland                         |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  |       +     +  +     +  +  +  +  +  +     +  +     +        +  +  +  +  +|  33        |
      Carcinoma, Metastatic, Kidney        |                                                                          |          1 |
      Leukemia Mononuclear                 |       X        X        X  X     X                 X                     |          9 |
      Sarcoma                              |                                                                          |          1 |
      Renal Tubule, Carcinoma              |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         |       +     +  +     +  +  +  +  +  +     +  +     +        +  +  +  +  +|  33        |
      Leukemia Mononuclear                 |                                  X                                       |          1 |
      Mesothelioma Malignant, Metastatic,  |                                                                          |            |
           Uncertain Primary Site          |                                                                X         |          1 |
 __________________________________________________________________________________________________________________________________ 
 SYSTEMIC LESIONS                          |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Leukemia Mononuclear                 |       X  X     X  X     X  X     X     X        X  X  X                  |         24 |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  43                                                               
NTP Experiment-Test: 05188-05                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                       SODIUM XYLENESULFONATE                                  Date: 09/19/95  
Route: SKIN APPLICATION                                                                                           Time: 20:55:17  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 5| 7| 6| 5| 7| 7| 6| 6| 5| 7| 7| 4| 7| 6| 7| 6| 6| 5| 7| 5| 6| 6| 6| 7|             
                             DAY ON TEST   | 0| 3| 3| 2| 7| 1| 3| 5| 0| 7| 0| 3| 3| 3| 5| 3| 2| 6| 9| 3| 7| 5| 4| 2| 0|             
                                           | 0| 8| 5| 2| 1| 8| 5| 2| 6| 3| 8| 5| 9| 5| 0| 5| 2| 6| 4| 5| 9| 3| 6| 1| 8|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    120                                    | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
    MG/KG                                  | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +     +  +  +     +  +  +  +     +     +     +  +  +     +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +     +  +  +     +  +  +  +     +     +     +  +  +     +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +     +  +  +     +  +  +  +     +     +     +  +  +     +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +     +  +  +     +  +  +  +     +     +     +  +  +     +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +     +  +  +     +  +  +  +     +     +     +  +  +     +  +  +  +  +|             
      Carcinoma, Metastatic, Kidney        |                                                                          |             
      Leiomyosarcoma, Metastatic, Stomach, |                                                                          |             
           Forestomach                     |                                                                          |             
      Sarcoma, Metastatic, Mesentery       |                                                 X                        |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +     +  +  +     +  +  +  +     +     +     +  +  +     +  +  +  +  +|             
      Leiomyosarcoma, Metastatic, Stomach, |                                                                          |             
           Forestomach                     |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +     +  +  +     +  +  +  +     +     +     +  +  +     +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +     +     +  +  +  +  +  +  +  +  +|             
      Histiocytic Sarcoma                  |                                                                X         |             
      Leiomyosarcoma, Metastatic, Stomach, |                                                                          |             
           Forestomach                     |                                                                          |             
      Leukemia Mononuclear                 | X     X           X              X        X        X     X              X|             
                                            __________________________________________________________________________|             
   Mesentery                               |                            +        +           +                        |             
      Carcinoma, Metastatic, Kidney        |                                                                          |             
      Leiomyosarcoma, Metastatic, Stomach, |                                                                          |             
           Forestomach                     |                                                                          |             
      Leukemia Mononuclear                 |                                                                          |             
      Sarcoma                              |                                                 X                        |             
                                            __________________________________________________________________________|             
   Oral Mucosa                             |                +                                                     +   |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +     +  +  +     +  +  +  +     +     +     +  +  +     +  +  +  +  +|             
      Carcinoma, Metastatic, Kidney        |                                                                          |             
      Histiocytic Sarcoma                  |                                                                X         |             
      Leiomyosarcoma, Metastatic, Stomach, |                                                                          |             
           Forestomach                     |                                                                          |             
      Leukemia Mononuclear                 |                                                                          |             
      Mixed Tumor Benign                   |                                                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +     +  +  +     +  +  +  +     +     +     +  +  +     +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +     +  +  +     +  +  +  +     +     +     +  +  +     +  +  +  +  +|             
      Leiomyosarcoma                       |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +     +  +  +     +  +  +  +     +     +     +  +  +     +  +  +  +  +|             
      Leiomyosarcoma                       |                                                                          |             
      Sarcoma, Metastatic, Mesentery       |                                                 X                        |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood Vessel                            | +  +     +  +  +     +  +  +  +     +     +     +  +  +     +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Heart                                   | +  +     +  +  +     +  +  +  +     +     +     +  +  +     +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                    X                     |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  44                                                               
NTP Experiment-Test: 05188-05                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                       SODIUM XYLENESULFONATE                                  Date: 09/19/95  
Route: SKIN APPLICATION                                                                                           Time: 20:55:17  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 5| 7| 6| 5| 7| 7| 6| 6| 5| 7| 7| 4| 7| 6| 7| 6| 6| 5| 7| 5| 6| 6| 6| 7|             
                             DAY ON TEST   | 0| 3| 3| 2| 7| 1| 3| 5| 0| 7| 0| 3| 3| 3| 5| 3| 2| 6| 9| 3| 7| 5| 4| 2| 0|             
                                           | 0| 8| 5| 2| 1| 8| 5| 2| 6| 3| 8| 5| 9| 5| 0| 5| 2| 6| 4| 5| 9| 3| 6| 1| 8|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    120                                    | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
    MG/KG                                  | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Cortex                          | +  +     +  +  +     +  +  +  +     +     +     +  +  +     +  +  +  +  +|             
      Leiomyosarcoma, Metastatic, Stomach, |                                                                          |             
           Forestomach                     |                                                                          |             
      Leukemia Mononuclear                 |                                           X        X                    X|             
                                            __________________________________________________________________________|             
   Adrenal Medulla                         | +  +     +  +  +     +  +  +  +     +     +     +  +  +     +  +  +  +  +|             
      Leukemia Mononuclear                 |                                           X        X                    X|             
      Pheochromocytoma Benign              |                               X                       X                  |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +     +  +  +     +  +  +  +     +     +     +  +  +     +  +  +  +  +|             
      Carcinoma, Metastatic, Kidney        |                                                                          |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +     M  +  +     +  +  +  +     +     +     +  +  +     +  +  +  M  +|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +     +  +  +     +  +  +  +     +     +     +  +  +     +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
      Pars Distalis, Adenoma               | X        X     X     X  X  X  X     X     X     X  X  X     X     X  X  X|             
      Pars Distalis, Adenoma, Multiple     |             X                                                            |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +     +  +  +     +  +  +  +     +     +     +  +  +     +  +  +  +  +|             
      C-Cell, Adenoma                      |                                                 X                        |             
      Follicular Cell, Carcinoma           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Coagulating Gland                       |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              | +  +     +  +  +     +  +  +  +     +     +     +  +  +     +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Preputial Gland                         | +  +     +  +  +     +  +  +  +     +     +     +  +  +     +  +  +  +  +|             
      Adenoma                              |                                                                          |             
      Carcinoma                            | X                                                                        |             
      Leukemia Mononuclear                 |                                           X                              |             
                                            __________________________________________________________________________|             
   Prostate                                | +  +     +  +  +     +  +  +  +     +     +     +  +  +     +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         | +  +     +  +  +     +  +  +  +     +     +     +  +  +     +  +  +  +  +|             
      Carcinoma, Metastatic, Kidney        |                                                                          |             
      Leiomyosarcoma, Metastatic, Stomach, |                                                                          |             
           Forestomach                     |                                                                          |             
                                            __________________________________________________________________________|             
   Testes                                  | +  +     +  +  +     +  +  +  +     +     +     +  +  +     +  +  +  +  +|             
      Bilateral, Interstitial Cell, Adenoma|    X     X                                                               |             
      Interstitial Cell, Adenoma           |                X        X                 X                              |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +     +  +  +     +  +  +  +     +     +     +  +  +     +  +  +  +  +|             
      Histiocytic Sarcoma                  |                                                                X         |             
      Leukemia Mononuclear                 |                                           X        X                    X|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  45                                                               
NTP Experiment-Test: 05188-05                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                       SODIUM XYLENESULFONATE                                  Date: 09/19/95  
Route: SKIN APPLICATION                                                                                           Time: 20:55:17  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 5| 7| 6| 5| 7| 7| 6| 6| 5| 7| 7| 4| 7| 6| 7| 6| 6| 5| 7| 5| 6| 6| 6| 7|             
                             DAY ON TEST   | 0| 3| 3| 2| 7| 1| 3| 5| 0| 7| 0| 3| 3| 3| 5| 3| 2| 6| 9| 3| 7| 5| 4| 2| 0|             
                                           | 0| 8| 5| 2| 1| 8| 5| 2| 6| 3| 8| 5| 9| 5| 0| 5| 2| 6| 4| 5| 9| 3| 6| 1| 8|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    120                                    | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
    MG/KG                                  | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node                              |    +           +     +  +  +  +     +     +        +           +  +  +  +|             
      Mediastinal, Carcinoma, Metastatic,  |                                                                          |             
           Kidney                          |                                                                          |             
      Mediastinal, Histiocytic Sarcoma     |                                                                X         |             
      Mediastinal, Leukemia Mononuclear    |                                           X                              |             
      Renal, Carcinoma, Metastatic, Kidney |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +     +  +  +     +  +  +  +     +     +     +  +  +     +  +  +  +  +|             
      Histiocytic Sarcoma                  |                                                                X         |             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +     +  +  +     +  +  +  +     +     +     +  +  +     +  +  +  +  +|             
      Carcinoma, Metastatic, Kidney        |                                                                          |             
      Leukemia Mononuclear                 |                                           X                              |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +     +     +  +  +  +  +  +  +  +  +|             
      Histiocytic Sarcoma                  |                                                                X         |             
      Leiomyosarcoma, Metastatic, Stomach, |                                                                          |             
           Forestomach                     |                                                                          |             
      Leukemia Mononuclear                 | X     X           X              X        X        X     X              X|             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +     +  +  +     +  +  +  +     +     +     +  +  +     +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +     +  +  +     +  +  +  +     +     +     +  +  +     +  M  +  +  +|             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Keratoacanthoma                      |                                                    X                     |             
      Squamous Cell Papilloma              |                                                                          |             
      Skin, Site of Application, Basal     |                                                                          |             
          Cell Adenoma                     |                                                                          |             
      Subcutaneous Tissue, Fibroma         |                                                    X                     |             
      Subcutaneous Tissue, Leukemia        |                                                                          |             
          Mononuclear                      |                                                                          |             
      Subcutaneous Tissue, Schwannoma      |                                                                          |             
          Malignant                        |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +     +  +  +     +  +  +  +     +     +     +  +  +     +  +  +  +  +|             
      Osteosarcoma                         |                                                                          |             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |                                                                +         |             
      Carcinoma, Metastatic, Kidney        |                                                                          |             
      Histiocytic Sarcoma                  |                                                                X         |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +     +  +  +     +  +  +  +     +     +     +  +  +     +  +  +  +  +|             
      Oligodendroglioma Malignant          |             X                                                            |             
                                            __________________________________________________________________________|             
   Peripheral Nerve                        |                      +                                                   |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  46                                                               
NTP Experiment-Test: 05188-05                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                       SODIUM XYLENESULFONATE                                  Date: 09/19/95  
Route: SKIN APPLICATION                                                                                           Time: 20:55:17  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 5| 7| 6| 5| 7| 7| 6| 6| 5| 7| 7| 4| 7| 6| 7| 6| 6| 5| 7| 5| 6| 6| 6| 7|             
                             DAY ON TEST   | 0| 3| 3| 2| 7| 1| 3| 5| 0| 7| 0| 3| 3| 3| 5| 3| 2| 6| 9| 3| 7| 5| 4| 2| 0|             
                                           | 0| 8| 5| 2| 1| 8| 5| 2| 6| 3| 8| 5| 9| 5| 0| 5| 2| 6| 4| 5| 9| 3| 6| 1| 8|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    120                                    | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
    MG/KG                                  | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Spinal Cord                             |                      +                                                   |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +     +  +  +     +  +  +  +     +     +     +  +  +     +  +  +  +  +|             
      Carcinoma, Metastatic, Kidney        |                                                                          |             
      Histiocytic Sarcoma                  |                                                                X         |             
      Leukemia Mononuclear                 | X                                         X        X                    X|             
      Osteosarcoma, Metastatic, Bone       |                                                                          |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +     +  +  +     +  +  +  +     +     +     +  +  +     +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +     +  +  +     +  +  +  +     +     +     +  +  +     +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |          +                                                               |             
                                            __________________________________________________________________________|             
   Zymbal's Gland                          |    +                                      +                              |             
      Adenoma                              |                                           X                              |             
      Carcinoma                            |    X                                                                     |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +     +  +  +     +  +  +  +     +     +     +  +  +     +  +  +  +  +|             
      Leukemia Mononuclear                 | X                                         X        X                    X|             
      Renal Tubule, Carcinoma              |                                                                          |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +     +  +  +     +  +  +  +     +     +     +  +  +     +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
      Transitional Epithelium, Carcinoma   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 SYSTEMIC LESIONS                          |                                                                          |             
                                            __________________________________________________________________________|             
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Histiocytic Sarcoma                  |                                                                X         |             
      Leukemia Mononuclear                 | X     X           X              X        X        X     X              X|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  47                                                               
NTP Experiment-Test: 05188-05                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                       SODIUM XYLENESULFONATE                                  Date: 09/19/95  
Route: SKIN APPLICATION                                                                                           Time: 20:55:17  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 6| 6| 7| 6| 7| 5| 6| 6| 5| 5| 2| 6| 6| 7| 5| 7| 6| 4| 7| 5| 6| 4| 7| 4|            |
                             DAY ON TEST   | 9| 2| 7| 1| 1| 3| 3| 7| 0| 2| 6| 5| 5| 4| 3| 6| 2| 7| 8| 0| 9| 3| 7| 3| 8|            |
                                           | 5| 2| 2| 5| 2| 5| 5| 3| 9| 7| 8| 7| 9| 6| 5| 2| 6| 2| 9| 4| 6| 7| 7| 5| 7|            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     T      |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|     A      |
    120                                    | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|     L      |
    MG/KG                                  | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +     +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +     +|  41        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +     +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +     +|  41        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +     +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +     +|  41        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +     +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +     +|  41        |
      Leukemia Mononuclear                 |                      X                                                   |          1 |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +     +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +     +|  41        |
      Carcinoma, Metastatic, Kidney        |                   X                                                      |          1 |
      Leiomyosarcoma, Metastatic, Stomach, |                                                                          |            |
           Forestomach                     |                                                       X                  |          1 |
      Sarcoma, Metastatic, Mesentery       |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +     +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +     +|  41        |
      Leiomyosarcoma, Metastatic, Stomach, |                                                                          |            |
           Forestomach                     |                                                       X                  |          1 |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +     +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +     +|  41        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +|  47        |
      Histiocytic Sarcoma                  |                                                                          |          1 |
      Leiomyosarcoma, Metastatic, Stomach, |                                                                          |            |
           Forestomach                     |                                                       X                  |          1 |
      Leukemia Mononuclear                 |       X        X     X                       X                    X  X   |         14 |
                                            __________________________________________________________________________|____________|
   Mesentery                               |                   +  +     +                       +  +           +      |   9        |
      Carcinoma, Metastatic, Kidney        |                   X                                                      |          1 |
      Leiomyosarcoma, Metastatic, Stomach, |                                                                          |            |
           Forestomach                     |                                                       X                  |          1 |
      Leukemia Mononuclear                 |                      X                                                   |          1 |
      Sarcoma                              |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Oral Mucosa                             |          +                                                               |   3        |
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +     +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +     +|  41        |
      Carcinoma, Metastatic, Kidney        |                   X                                                      |          1 |
      Histiocytic Sarcoma                  |                                                                          |          1 |
      Leiomyosarcoma, Metastatic, Stomach, |                                                                          |            |
           Forestomach                     |                                                       X                  |          1 |
      Leukemia Mononuclear                 |                      X                                                   |          1 |
      Mixed Tumor Benign                   |                                              X                           |          1 |
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +     +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +     +|  41        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +     +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +     +|  41        |
      Leiomyosarcoma                       |                                                       X                  |          1 |
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +     +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +     +|  41        |
      Leiomyosarcoma                       |                                                       X                  |          1 |
      Sarcoma, Metastatic, Mesentery       |                                                                          |          1 |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  48                                                               
NTP Experiment-Test: 05188-05                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                       SODIUM XYLENESULFONATE                                  Date: 09/19/95  
Route: SKIN APPLICATION                                                                                           Time: 20:55:17  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 6| 6| 7| 6| 7| 5| 6| 6| 5| 5| 2| 6| 6| 7| 5| 7| 6| 4| 7| 5| 6| 4| 7| 4|            |
                             DAY ON TEST   | 9| 2| 7| 1| 1| 3| 3| 7| 0| 2| 6| 5| 5| 4| 3| 6| 2| 7| 8| 0| 9| 3| 7| 3| 8|            |
                                           | 5| 2| 2| 5| 2| 5| 5| 3| 9| 7| 8| 7| 9| 6| 5| 2| 6| 2| 9| 4| 6| 7| 7| 5| 7|            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     T      |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|     A      |
    120                                    | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|     L      |
    MG/KG                                  | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
                                           |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood Vessel                            | +  +  +  +  +     +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +     +|  41        |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +     +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +     +|  41        |
      Leukemia Mononuclear                 |                                                                   X      |          2 |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Cortex                          | +  +  +  +  +     +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +     +|  41        |
      Leiomyosarcoma, Metastatic, Stomach, |                                                                          |            |
           Forestomach                     |                                                       X                  |          1 |
      Leukemia Mononuclear                 |                      X                                            X      |          5 |
                                            __________________________________________________________________________|____________|
   Adrenal Medulla                         | +  +  +  +  +     +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +     +|  41        |
      Leukemia Mononuclear                 |                      X                                            X      |          5 |
      Pheochromocytoma Benign              |                                                                X         |          3 |
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +     +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +     +|  41        |
      Carcinoma, Metastatic, Kidney        |                   X                                                      |          1 |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +  +  +     +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +     +|  39        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +     +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +     +|  41        |
      Leukemia Mononuclear                 |                      X                                                   |          1 |
      Pars Distalis, Adenoma               | X  X        X        X  X           X        X  X  X  X  X  X  X  X      |         30 |
      Pars Distalis, Adenoma, Multiple     |          X                 X  X                                          |          4 |
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +     +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +     +|  41        |
      C-Cell, Adenoma                      |                                                                          |          1 |
      Follicular Cell, Carcinoma           |                            X                                             |          1 |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Coagulating Gland                       |                                                 +                        |   1        |
                                            __________________________________________________________________________|____________|
   Epididymis                              | +  +  +  +  +     +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +     +|  41        |
                                            __________________________________________________________________________|____________|
   Preputial Gland                         | +  +  +  +  +     +  +  +  +  +  +  M  +     +  +  +  +  +  +  +  +     +|  40        |
      Adenoma                              |                            X                                             |          1 |
      Carcinoma                            |                                                                          |          1 |
      Leukemia Mononuclear                 |                      X                                                   |          2 |
                                            __________________________________________________________________________|____________|
   Prostate                                | +  +  +  +  +     +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +     +|  41        |
      Leukemia Mononuclear                 |                      X                                                   |          1 |
                                            __________________________________________________________________________|____________|
   Seminal Vesicle                         | +  +  +  +  +     +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +     +|  41        |
      Carcinoma, Metastatic, Kidney        |                   X                                                      |          1 |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  49                                                               
NTP Experiment-Test: 05188-05                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                       SODIUM XYLENESULFONATE                                  Date: 09/19/95  
Route: SKIN APPLICATION                                                                                           Time: 20:55:17  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 6| 6| 7| 6| 7| 5| 6| 6| 5| 5| 2| 6| 6| 7| 5| 7| 6| 4| 7| 5| 6| 4| 7| 4|            |
                             DAY ON TEST   | 9| 2| 7| 1| 1| 3| 3| 7| 0| 2| 6| 5| 5| 4| 3| 6| 2| 7| 8| 0| 9| 3| 7| 3| 8|            |
                                           | 5| 2| 2| 5| 2| 5| 5| 3| 9| 7| 8| 7| 9| 6| 5| 2| 6| 2| 9| 4| 6| 7| 7| 5| 7|            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     T      |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|     A      |
    120                                    | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|     L      |
    MG/KG                                  | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 __________________________________________________________________________________________________________________________________ 
 GENITAL SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
      Leiomyosarcoma, Metastatic, Stomach, |                                                                          |            |
           Forestomach                     |                                                       X                  |          1 |
                                            __________________________________________________________________________|____________|
   Testes                                  | +  +  +  +  +     +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +     +|  41        |
      Bilateral, Interstitial Cell, Adenoma| X     X                                                  X               |          5 |
      Interstitial Cell, Adenoma           |                   X           X        X     X  X                        |          8 |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +     +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +     +|  41        |
      Histiocytic Sarcoma                  |                                                                          |          1 |
      Leukemia Mononuclear                 |                      X                                                   |          4 |
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +  +  +  +  +     +  +  +  +  +  +  +        +  +     +        +  +     +|  31        |
      Mediastinal, Carcinoma, Metastatic,  |                                                                          |            |
           Kidney                          |                   X                                                      |          1 |
      Mediastinal, Histiocytic Sarcoma     |                                                                          |          1 |
      Mediastinal, Leukemia Mononuclear    |                      X                                                   |          2 |
      Renal, Carcinoma, Metastatic, Kidney |                   X                                                      |          1 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +  +  +     +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  M     +|  40        |
      Histiocytic Sarcoma                  |                                                                          |          1 |
      Leukemia Mononuclear                 |                      X                                                   |          1 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +     +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +     +|  41        |
      Carcinoma, Metastatic, Kidney        |                   X                                                      |          1 |
      Leukemia Mononuclear                 |                      X                                                   |          2 |
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +|  47        |
      Histiocytic Sarcoma                  |                                                                          |          1 |
      Leiomyosarcoma, Metastatic, Stomach, |                                                                          |            |
           Forestomach                     |                                                       X                  |          1 |
      Leukemia Mononuclear                 |       X        X     X              X        X                    X  X   |         15 |
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +  +  +  +     +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +     +|  41        |
      Leukemia Mononuclear                 |                      X                                                   |          1 |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +  +  +     +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +     +|  40        |
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Keratoacanthoma                      |                                                                          |          1 |
      Squamous Cell Papilloma              |                                           X                              |          1 |
      Skin, Site of Application, Basal     |                                                                          |            |
          Cell Adenoma                     |                                                    X                     |          1 |
      Subcutaneous Tissue, Fibroma         |                                                                          |          1 |
      Subcutaneous Tissue, Leukemia        |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  50                                                               
NTP Experiment-Test: 05188-05                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                       SODIUM XYLENESULFONATE                                  Date: 09/19/95  
Route: SKIN APPLICATION                                                                                           Time: 20:55:17  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 6| 6| 7| 6| 7| 5| 6| 6| 5| 5| 2| 6| 6| 7| 5| 7| 6| 4| 7| 5| 6| 4| 7| 4|            |
                             DAY ON TEST   | 9| 2| 7| 1| 1| 3| 3| 7| 0| 2| 6| 5| 5| 4| 3| 6| 2| 7| 8| 0| 9| 3| 7| 3| 8|            |
                                           | 5| 2| 2| 5| 2| 5| 5| 3| 9| 7| 8| 7| 9| 6| 5| 2| 6| 2| 9| 4| 6| 7| 7| 5| 7|            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     T      |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|     A      |
    120                                    | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|     L      |
    MG/KG                                  | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 __________________________________________________________________________________________________________________________________ 
 INTEGUMENTARY SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
          Mononuclear                      |                      X                                                   |          1 |
      Subcutaneous Tissue, Schwannoma      |                                                                          |            |
          Malignant                        |                                                             X            |          1 |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +     +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +     +|  41        |
      Osteosarcoma                         |                               X                                          |          1 |
                                            __________________________________________________________________________|____________|
   Skeletal Muscle                         |                   +                                                      |   2        |
      Carcinoma, Metastatic, Kidney        |                   X                                                      |          1 |
      Histiocytic Sarcoma                  |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +     +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +     +|  41        |
      Oligodendroglioma Malignant          |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Peripheral Nerve                        |                                                                          |   1        |
                                            __________________________________________________________________________|____________|
   Spinal Cord                             |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +     +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +     +|  41        |
      Carcinoma, Metastatic, Kidney        |                   X                                                      |          1 |
      Histiocytic Sarcoma                  |                                                                          |          1 |
      Leukemia Mononuclear                 |       X              X              X        X                    X      |          9 |
      Osteosarcoma, Metastatic, Bone       |                               X                                          |          1 |
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +     +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +     +|  41        |
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +     +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +     +|  41        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Eye                                     |                                     +                                    |   2        |
                                            __________________________________________________________________________|____________|
   Zymbal's Gland                          |                                                                          |   2        |
      Adenoma                              |                                                                          |          1 |
      Carcinoma                            |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +     +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +     +|  41        |
      Leukemia Mononuclear                 |       X              X              X        X                    X      |          9 |
      Renal Tubule, Carcinoma              |                   X                                                      |          1 |
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +     +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +     +|  41        |
      Leukemia Mononuclear                 |                      X                                                   |          1 |
      Transitional Epithelium, Carcinoma   |                                                    X                     |          1 |
 __________________________________________________________________________________________________________________________________ 
 SYSTEMIC LESIONS                          |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  51                                                               
NTP Experiment-Test: 05188-05                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                       SODIUM XYLENESULFONATE                                  Date: 09/19/95  
Route: SKIN APPLICATION                                                                                           Time: 20:55:17  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 6| 6| 7| 6| 7| 5| 6| 6| 5| 5| 2| 6| 6| 7| 5| 7| 6| 4| 7| 5| 6| 4| 7| 4|            |
                             DAY ON TEST   | 9| 2| 7| 1| 1| 3| 3| 7| 0| 2| 6| 5| 5| 4| 3| 6| 2| 7| 8| 0| 9| 3| 7| 3| 8|            |
                                           | 5| 2| 2| 5| 2| 5| 5| 3| 9| 7| 8| 7| 9| 6| 5| 2| 6| 2| 9| 4| 6| 7| 7| 5| 7|            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     T      |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|     A      |
    120                                    | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|     L      |
    MG/KG                                  | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 __________________________________________________________________________________________________________________________________ 
 SYSTEMIC LESIONS - cont                   |                                                                          |            |
                                           |                                                                          |            |
      Histiocytic Sarcoma                  |                                                                          |          1 |
      Leukemia Mononuclear                 |       X        X     X              X        X                    X  X   |         15 |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  52                                                               
NTP Experiment-Test: 05188-05                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                       SODIUM XYLENESULFONATE                                  Date: 09/19/95  
Route: SKIN APPLICATION                                                                                           Time: 20:55:17  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 6| 7| 5| 7| 7| 4| 6| 5| 7| 7| 6| 6| 6| 5| 7| 7| 7| 5| 5| 7| 4| 3| 7|             
                             DAY ON TEST   | 3| 3| 6| 3| 6| 3| 3| 2| 5| 4| 3| 1| 3| 2| 4| 2| 3| 2| 3| 2| 6| 3| 8| 8| 3|             
                                           | 5| 5| 7| 5| 8| 1| 5| 8| 8| 7| 5| 9| 8| 9| 2| 4| 5| 6| 5| 5| 1| 0| 0| 2| 5|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    240                                    | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|             
    MG/KG                                  | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoid Tissue, Leukemia Mononuclear|                         X                                                |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Carcinoma                            |                                                                          |             
      Mesothelioma Malignant, Metastatic,  |                                                                          |             
           Uncertain Primary Site          |                            X                                             |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Mesothelioma Malignant, Metastatic,  |                                                                          |             
           Uncertain Primary Site          |                            X                                             |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Histiocytic Sarcoma                  |                                  X                                       |             
      Leukemia Mononuclear                 | X  X     X  X  X  X     X     X        X        X     X                 X|             
                                            __________________________________________________________________________|             
   Mesentery                               |    +                    +  +     +     +                                 |             
      Histiocytic Sarcoma                  |                                  X                                       |             
      Leukemia Mononuclear                 |                                        X                                 |             
      Mesothelioma Malignant, Metastatic,  |                                                                          |             
           Uncertain Primary Site          |                            X                                             |             
                                            __________________________________________________________________________|             
   Oral Mucosa                             |                                        +  +                             +|             
      Gingival, Squamous Cell Carcinoma    |                                           X                              |             
      Pharyngeal, Squamous Cell Carcinoma  |                                                                          |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Histiocytic Sarcoma                  |                                  X                                       |             
      Leukemia Mononuclear                 |                                                                          |             
      Mesothelioma Malignant, Metastatic,  |                                                                          |             
           Uncertain Primary Site          |                            X                                             |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
      Mesothelioma Malignant, Metastatic,  |                                                                          |             
           Uncertain Primary Site          |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood Vessel                            | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                         X              X                                 |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Histiocytic Sarcoma                  |                                  X                                       |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  53                                                               
NTP Experiment-Test: 05188-05                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                       SODIUM XYLENESULFONATE                                  Date: 09/19/95  
Route: SKIN APPLICATION                                                                                           Time: 20:55:17  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 6| 7| 5| 7| 7| 4| 6| 5| 7| 7| 6| 6| 6| 5| 7| 7| 7| 5| 5| 7| 4| 3| 7|             
                             DAY ON TEST   | 3| 3| 6| 3| 6| 3| 3| 2| 5| 4| 3| 1| 3| 2| 4| 2| 3| 2| 3| 2| 6| 3| 8| 8| 3|             
                                           | 5| 5| 7| 5| 8| 1| 5| 8| 8| 7| 5| 9| 8| 9| 2| 4| 5| 6| 5| 5| 1| 0| 0| 2| 5|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    240                                    | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|             
    MG/KG                                  | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
      Leukemia Mononuclear                 |             X     X     X     X        X                                X|             
                                            __________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |             X     X     X     X        X                                X|             
      Pheochromocytoma Malignant           |                                                             X            |             
      Pheochromocytoma Benign              |    X              X                       X        X                     |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Adenoma                              |          X                                                               |             
      Carcinoma                            |                                                                          |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  M  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                         X              X                                 |             
      Pars Distalis, Adenoma               | X  X  X  X     X  X  X  X        X  X  X     X                 X  X     X|             
      Pars Distalis, Adenoma, Multiple     |                                                    X                     |             
      Pars Distalis, Craniopharyngioma     |                   X                                                      |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Bilateral, C-Cell, Adenoma           |                                                                          |             
      Bilateral, C-Cell, Carcinoma         |    X                                                                     |             
      C-Cell, Adenoma                      | X           X  X                                      X                  |             
      Follicular Cell, Carcinoma           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Peritoneum                              |                            +                                             |             
      Mesothelioma Malignant, Metastatic,  |                                                                          |             
           Uncertain Primary Site          |                            X                                             |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Coagulating Gland                       |                                                                +         |             
                                            __________________________________________________________________________|             
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
      Mesothelioma Malignant, Metastatic,  |                                                                          |             
           Uncertain Primary Site          |                            X                                             |             
                                            __________________________________________________________________________|             
   Preputial Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                        X              X                  |             
      Mesothelioma Malignant, Metastatic,  |                                                                          |             
           Uncertain Primary Site          |                            X                                             |             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                        X                                 |             
      Mesothelioma Malignant, Metastatic,  |                                                                          |             
           Uncertain Primary Site          |                                                                          |             
                                            __________________________________________________________________________|             
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Mesothelioma Malignant, Metastatic,  |                                                                          |             
           Uncertain Primary Site          |                            X                                             |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  54                                                               
NTP Experiment-Test: 05188-05                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                       SODIUM XYLENESULFONATE                                  Date: 09/19/95  
Route: SKIN APPLICATION                                                                                           Time: 20:55:17  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 6| 7| 5| 7| 7| 4| 6| 5| 7| 7| 6| 6| 6| 5| 7| 7| 7| 5| 5| 7| 4| 3| 7|             
                             DAY ON TEST   | 3| 3| 6| 3| 6| 3| 3| 2| 5| 4| 3| 1| 3| 2| 4| 2| 3| 2| 3| 2| 6| 3| 8| 8| 3|             
                                           | 5| 5| 7| 5| 8| 1| 5| 8| 8| 7| 5| 9| 8| 9| 2| 4| 5| 6| 5| 5| 1| 0| 0| 2| 5|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    240                                    | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|             
    MG/KG                                  | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
      Bilateral, Interstitial Cell, Adenoma|    X  X     X           X  X  X           X     X  X  X  X  X            |             
      Interstitial Cell, Adenoma           | X        X     X     X              X                             X     X|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Histiocytic Sarcoma                  |                                  X                                       |             
      Leukemia Mononuclear                 |    X     X  X     X           X        X              X                 X|             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +     +|             
      Lumbar, Leukemia Mononuclear         |             X                                                            |             
      Mediastinal, Histiocytic Sarcoma     |                                  X                                       |             
      Mediastinal, Leukemia Mononuclear    |             X                 X        X                                X|             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |             X                 X        X                                X|             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |             X           X              X                                X|             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Histiocytic Sarcoma                  |                                  X                                       |             
      Leukemia Mononuclear                 | X  X     X  X  X  X     X     X        X        X     X                 X|             
      Mesothelioma Malignant, Metastatic,  |                                                                          |             
           Uncertain Primary Site          |                                                                          |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |             X                 X        X                                 |             
      Thymoma Benign                       |                                                          X               |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Basal Cell Adenoma                   |                                                    X                     |             
      Squamous Cell Papilloma              | X                                                                        |             
      Subcutaneous Tissue, Fibroma         |                   X                                                      |             
      Subcutaneous Tissue, Histiocytic     |                                                                          |             
          Sarcoma                          |                                  X                                       |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                         X                                                |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Histiocytic Sarcoma                  |                                  X                                       |             
      Leukemia Mononuclear                 | X  X     X  X     X     X     X        X              X                 X|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  55                                                               
NTP Experiment-Test: 05188-05                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                       SODIUM XYLENESULFONATE                                  Date: 09/19/95  
Route: SKIN APPLICATION                                                                                           Time: 20:55:17  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 6| 7| 5| 7| 7| 4| 6| 5| 7| 7| 6| 6| 6| 5| 7| 7| 7| 5| 5| 7| 4| 3| 7|             
                             DAY ON TEST   | 3| 3| 6| 3| 6| 3| 3| 2| 5| 4| 3| 1| 3| 2| 4| 2| 3| 2| 3| 2| 6| 3| 8| 8| 3|             
                                           | 5| 5| 7| 5| 8| 1| 5| 8| 8| 7| 5| 9| 8| 9| 2| 4| 5| 6| 5| 5| 1| 0| 0| 2| 5|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    240                                    | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|             
    MG/KG                                  | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |             +                                                            |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                                           +                              |             
      Squamous Cell Carcinoma, Metastatic, |                                                                          |             
           Oral Mucosa                     |                                           X                              |             
                                            __________________________________________________________________________|             
   Zymbal's Gland                          |                                                          +               |             
      Carcinoma                            |                                                          X               |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 | X  X     X  X           X     X        X        X     X                 X|             
      Mesothelioma Malignant, Metastatic,  |                                                                          |             
           Uncertain Primary Site          |                            X                                             |             
      Renal Tubule, Adenoma                |                   X                                                      |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                        X                                 |             
      Mesothelioma Malignant, Metastatic,  |                                                                          |             
           Uncertain Primary Site          |                            X                                             |             
 _____________________________________________________________________________________________________________________|             
 SYSTEMIC LESIONS                          |                                                                          |             
                                            __________________________________________________________________________|             
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Histiocytic Sarcoma                  |                                  X                                       |             
      Leukemia Mononuclear                 | X  X     X  X  X  X     X     X        X        X     X                 X|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  56                                                               
NTP Experiment-Test: 05188-05                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                       SODIUM XYLENESULFONATE                                  Date: 09/19/95  
Route: SKIN APPLICATION                                                                                           Time: 20:55:17  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 6| 5| 6| 5| 5| 7| 7| 6| 5| 5| 5| 6| 7| 6| 5| 7| 5| 7| 5| 5| 7| 6| 7| 7|            |
                             DAY ON TEST   | 3| 8| 4| 6| 6| 9| 2| 3| 7| 5| 3| 9| 5| 0| 1| 2| 0| 8| 3| 6| 2| 1| 3| 1| 2|            |
                                           | 3| 7| 1| 9| 2| 4| 8| 5| 9| 6| 0| 0| 2| 2| 6| 0| 2| 2| 5| 7| 7| 9| 1| 4| 6|            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     T      |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2|     A      |
    240                                    | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|     L      |
    MG/KG                                  | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Lymphoid Tissue, Leukemia Mononuclear|                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Carcinoma                            | X                                                                        |          1 |
      Mesothelioma Malignant, Metastatic,  |                                                                          |            |
           Uncertain Primary Site          |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Mesothelioma Malignant, Metastatic,  |                                                                          |            |
           Uncertain Primary Site          |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Histiocytic Sarcoma                  |                                                                          |          1 |
      Leukemia Mononuclear                 |       X     X     X  X     X     X        X     X     X  X     X     X  X|         25 |
                                            __________________________________________________________________________|____________|
   Mesentery                               |                                  +     +        +                        |   8        |
      Histiocytic Sarcoma                  |                                                                          |          1 |
      Leukemia Mononuclear                 |                                  X              X                        |          3 |
      Mesothelioma Malignant, Metastatic,  |                                                                          |            |
           Uncertain Primary Site          |                                        X                                 |          2 |
                                            __________________________________________________________________________|____________|
   Oral Mucosa                             |                      +                          +                    +   |   6        |
      Gingival, Squamous Cell Carcinoma    |                                                                          |          1 |
      Pharyngeal, Squamous Cell Carcinoma  |                      X                                                   |          1 |
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Histiocytic Sarcoma                  |                                                                          |          1 |
      Leukemia Mononuclear                 |                                  X              X                        |          2 |
      Mesothelioma Malignant, Metastatic,  |                                                                          |            |
           Uncertain Primary Site          |                                        X                                 |          2 |
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Leukemia Mononuclear                 |                                                 X                        |          1 |
      Mesothelioma Malignant, Metastatic,  |                                                                          |            |
           Uncertain Primary Site          |                                        X                                 |          1 |
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood Vessel                            | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  57                                                               
NTP Experiment-Test: 05188-05                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                       SODIUM XYLENESULFONATE                                  Date: 09/19/95  
Route: SKIN APPLICATION                                                                                           Time: 20:55:17  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 6| 5| 6| 5| 5| 7| 7| 6| 5| 5| 5| 6| 7| 6| 5| 7| 5| 7| 5| 5| 7| 6| 7| 7|            |
                             DAY ON TEST   | 3| 8| 4| 6| 6| 9| 2| 3| 7| 5| 3| 9| 5| 0| 1| 2| 0| 8| 3| 6| 2| 1| 3| 1| 2|            |
                                           | 3| 7| 1| 9| 2| 4| 8| 5| 9| 6| 0| 0| 2| 2| 6| 0| 2| 2| 5| 7| 7| 9| 1| 4| 6|            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     T      |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2|     A      |
    240                                    | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|     L      |
    MG/KG                                  | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 __________________________________________________________________________________________________________________________________ 
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |            |
                                           |                                                                          |            |
      Leukemia Mononuclear                 |                                  X        X                              |          4 |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Histiocytic Sarcoma                  |                                                                          |          1 |
      Leukemia Mononuclear                 |       X     X              X     X              X                        |         11 |
                                            __________________________________________________________________________|____________|
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Leukemia Mononuclear                 |       X     X              X     X              X                        |         11 |
      Pheochromocytoma Malignant           |                                                                          |          1 |
      Pheochromocytoma Benign              |                                        X        X     X        X     X   |          9 |
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Adenoma                              |    X                       X                                             |          3 |
      Carcinoma                            |                                                          X               |          1 |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +  +  +  M  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +|  45        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Leukemia Mononuclear                 |             X                                   X                        |          4 |
      Pars Distalis, Adenoma               |          X     X  X        X  X  X  X  X  X  X  X  X  X  X        X  X   |         31 |
      Pars Distalis, Adenoma, Multiple     |             X           X                                   X           X|          5 |
      Pars Distalis, Craniopharyngioma     |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Bilateral, C-Cell, Adenoma           |                                                 X                        |          1 |
      Bilateral, C-Cell, Carcinoma         |                                                                          |          1 |
      C-Cell, Adenoma                      |                                                                         X|          5 |
      Follicular Cell, Carcinoma           |                                                       X                  |          1 |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Peritoneum                              |                                        +                                 |   2        |
      Mesothelioma Malignant, Metastatic,  |                                                                          |            |
           Uncertain Primary Site          |                                        X                                 |          2 |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Coagulating Gland                       |                         +                                                |   2        |
                                            __________________________________________________________________________|____________|
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Leukemia Mononuclear                 |                                                 X                        |          1 |
      Mesothelioma Malignant, Metastatic,  |                                                                          |            |
           Uncertain Primary Site          |                                        X                                 |          2 |
                                            __________________________________________________________________________|____________|
   Preputial Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Leukemia Mononuclear                 |                                                          X           X   |          2 |
                                            __________________________________________________________________________|____________|
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  58                                                               
NTP Experiment-Test: 05188-05                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                       SODIUM XYLENESULFONATE                                  Date: 09/19/95  
Route: SKIN APPLICATION                                                                                           Time: 20:55:17  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 6| 5| 6| 5| 5| 7| 7| 6| 5| 5| 5| 6| 7| 6| 5| 7| 5| 7| 5| 5| 7| 6| 7| 7|            |
                             DAY ON TEST   | 3| 8| 4| 6| 6| 9| 2| 3| 7| 5| 3| 9| 5| 0| 1| 2| 0| 8| 3| 6| 2| 1| 3| 1| 2|            |
                                           | 3| 7| 1| 9| 2| 4| 8| 5| 9| 6| 0| 0| 2| 2| 6| 0| 2| 2| 5| 7| 7| 9| 1| 4| 6|            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     T      |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2|     A      |
    240                                    | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|     L      |
    MG/KG                                  | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 __________________________________________________________________________________________________________________________________ 
 GENITAL SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
      Leukemia Mononuclear                 |             X                    X              X                        |          5 |
      Mesothelioma Malignant, Metastatic,  |                                                                          |            |
           Uncertain Primary Site          |                                        X                                 |          2 |
                                            __________________________________________________________________________|____________|
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Leukemia Mononuclear                 |                                  X              X                        |          3 |
      Mesothelioma Malignant, Metastatic,  |                                                                          |            |
           Uncertain Primary Site          |                                        X                                 |          1 |
                                            __________________________________________________________________________|____________|
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Mesothelioma Malignant, Metastatic,  |                                                                          |            |
           Uncertain Primary Site          |                                        X                                 |          2 |
      Bilateral, Interstitial Cell, Adenoma|                      X  X                       X              X     X   |         17 |
      Interstitial Cell, Adenoma           | X     X                                X  X           X  X               |         13 |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Histiocytic Sarcoma                  |                                                                          |          1 |
      Leukemia Mononuclear                 |       X     X              X     X        X     X     X                  |         15 |
                                            __________________________________________________________________________|____________|
   Lymph Node                              |       +     +  +  +  +  +  +  +  +  +  +     +  +     +  +  +  +  +      |  41        |
      Lumbar, Leukemia Mononuclear         |                                                                          |          1 |
      Mediastinal, Histiocytic Sarcoma     |                                                                          |          1 |
      Mediastinal, Leukemia Mononuclear    |       X     X                    X              X                        |          8 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Leukemia Mononuclear                 |             X                                   X                        |          6 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Leukemia Mononuclear                 |       X     X                    X              X     X                  |          9 |
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Histiocytic Sarcoma                  |                                                                          |          1 |
      Leukemia Mononuclear                 |       X     X     X  X     X     X        X     X     X  X           X  X|         24 |
      Mesothelioma Malignant, Metastatic,  |                                                                          |            |
           Uncertain Primary Site          |                                        X                                 |          1 |
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Leukemia Mononuclear                 |                                  X              X                        |          5 |
      Thymoma Benign                       |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Basal Cell Adenoma                   |                                                                          |          1 |
      Squamous Cell Papilloma              |                                                                          |          1 |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  59                                                               
NTP Experiment-Test: 05188-05                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                       SODIUM XYLENESULFONATE                                  Date: 09/19/95  
Route: SKIN APPLICATION                                                                                           Time: 20:55:17  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 6| 5| 6| 5| 5| 7| 7| 6| 5| 5| 5| 6| 7| 6| 5| 7| 5| 7| 5| 5| 7| 6| 7| 7|            |
                             DAY ON TEST   | 3| 8| 4| 6| 6| 9| 2| 3| 7| 5| 3| 9| 5| 0| 1| 2| 0| 8| 3| 6| 2| 1| 3| 1| 2|            |
                                           | 3| 7| 1| 9| 2| 4| 8| 5| 9| 6| 0| 0| 2| 2| 6| 0| 2| 2| 5| 7| 7| 9| 1| 4| 6|            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     T      |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2|     A      |
    240                                    | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|     L      |
    MG/KG                                  | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 __________________________________________________________________________________________________________________________________ 
 INTEGUMENTARY SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
      Subcutaneous Tissue, Fibroma         |                   X                                         X            |          3 |
      Subcutaneous Tissue, Histiocytic     |                                                                          |            |
          Sarcoma                          |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Leukemia Mononuclear                 |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Histiocytic Sarcoma                  |                                                                          |          1 |
      Leukemia Mononuclear                 |       X     X     X  X     X     X        X     X     X  X               |         20 |
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Eye                                     |                                                                          |   1        |
                                            __________________________________________________________________________|____________|
   Harderian Gland                         |                                                                          |   1        |
      Squamous Cell Carcinoma, Metastatic, |                                                                          |            |
           Oral Mucosa                     |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Zymbal's Gland                          |                                                                         +|   2        |
      Carcinoma                            |                                                                         X|          2 |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Leukemia Mononuclear                 |       X     X     X  X     X     X        X     X     X  X           X  X|         22 |
      Mesothelioma Malignant, Metastatic,  |                                                                          |            |
           Uncertain Primary Site          |                                        X                                 |          2 |
      Renal Tubule, Adenoma                |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Leukemia Mononuclear                 |                                                 X                        |          2 |
      Mesothelioma Malignant, Metastatic,  |                                                                          |            |
           Uncertain Primary Site          |                                        X                                 |          2 |
 __________________________________________________________________________________________________________________________________ 
 SYSTEMIC LESIONS                          |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Histiocytic Sarcoma                  |                                                                          |          1 |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  60                                                               
NTP Experiment-Test: 05188-05                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                       SODIUM XYLENESULFONATE                                  Date: 09/19/95  
Route: SKIN APPLICATION                                                                                           Time: 20:55:17  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 6| 5| 6| 5| 5| 7| 7| 6| 5| 5| 5| 6| 7| 6| 5| 7| 5| 7| 5| 5| 7| 6| 7| 7|            |
                             DAY ON TEST   | 3| 8| 4| 6| 6| 9| 2| 3| 7| 5| 3| 9| 5| 0| 1| 2| 0| 8| 3| 6| 2| 1| 3| 1| 2|            |
                                           | 3| 7| 1| 9| 2| 4| 8| 5| 9| 6| 0| 0| 2| 2| 6| 0| 2| 2| 5| 7| 7| 9| 1| 4| 6|            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     T      |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2|     A      |
    240                                    | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|     L      |
    MG/KG                                  | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 __________________________________________________________________________________________________________________________________ 
 SYSTEMIC LESIONS - cont                   |                                                                          |            |
                                           |                                                                          |            |
      Leukemia Mononuclear                 |       X     X     X  X     X     X        X     X     X  X     X     X  X|         25 |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  61                                                               
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                                  ----------              END OF REPORT             ----------                                      
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