Skip to Main Navigation
Skip to Page Content
Share This:
https://ntp.niehs.nih.gov/go/6771

TDMS Study 05188-05 Pathology Tables

NTP Experiment-Test: 05188-05  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                       SODIUM XYLENESULFONATE                                  Date: 04/04/96
Route: SKIN APPLICATION                                                                                           Time: 04:28:16




       Facility:  Battelle Columbus Laboratory

       Chemical CAS #:  1300-72-7

       Lock Date:  07/13/93

       Cage Range:  All

       Reasons For Removal:    All

       Removal Date Range:     All

       Treatment Groups:       Include All




































a  Number of animals examined microscopically at site and number of animals with lesion

                                                              Page   1


NTP Experiment-Test: 05188-05  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                       SODIUM XYLENESULFONATE                                  Date: 04/04/96  
Route: SKIN APPLICATION                                                                                           Time: 04:28:16  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS FEMALE                   0 MG/KG      60 MG/KG     120          240                                       
                                                                             MG/KG        MG/KG                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
DISPOSITION SUMMARY                                                                                                                 

  Animals Initially in Study                          50           50           50           50                                     
  Early Deaths                                                                                                                      
    Moribund Sacrifice                                14           10           15           12                                     
    Natural Death                                     13           24           18           22                                     
    Accidently Killed                                  1                                                                            
  Survivors                                                                                                                         
    Terminal Sacrifice                                22           15           17           16                                     
    Natural Death                                                   1                                                               

  Animals Examined Microscopically                    50           50           50           50                                     
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Esophagus                                          (50)         (35)         (33)         (50)                                   
      Periesophageal Tissue, Lipoma                                 1 (3%)       1 (3%)                                             
   Intestine Small, Duodenum                          (50)         (35)         (33)         (50)                                   
   Liver                                              (50)         (35)         (33)         (50)                                   
   Mesentery                                          (2)          (4)          (4)          (4)                                    
   Oral Mucosa                                        (1)                                    (2)                                    
      Gingival, Squamous Cell Carcinoma                1 (100%)                                                                     
   Pancreas                                           (50)         (35)         (33)         (50)                                   
   Stomach, Glandular                                 (50)         (35)         (33)         (50)                                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Heart                                              (50)         (35)         (33)         (50)                                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Cortex                                     (50)         (35)         (33)         (50)                                   
      Adenoma                                          1 (2%)       1 (3%)                    1 (2%)                                
   Adrenal Medulla                                    (50)         (35)         (33)         (50)                                   
      Pheochromocytoma Benign                          1 (2%)                    1 (3%)       2 (4%)                                
   Islets, Pancreatic                                 (50)         (35)         (33)         (50)                                   
      Adenoma                                                                    1 (3%)                                             
      Carcinoma                                        1 (2%)                                                                       
   Pituitary Gland                                    (50)         (35)         (33)         (50)                                   
      Pars Distalis, Adenoma                          29 (58%)     16 (46%)     19 (58%)     27 (54%)                               
      Pars Distalis, Adenoma, Multiple                 5 (10%)      1 (3%)                    2 (4%)                                
      Pars Distalis, Carcinoma                         1 (2%)                                                                       
      Pars Intermedia, Adenoma                                                                1 (2%)                                
   Thyroid Gland                                      (50)         (35)         (33)         (50)                                   

                                                             Page   2                                                               
NTP Experiment-Test: 05188-05  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                       SODIUM XYLENESULFONATE                                  Date: 04/04/96  
Route: SKIN APPLICATION                                                                                           Time: 04:28:16  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS FEMALE                   0 MG/KG      60 MG/KG     120          240                                       
                                                                             MG/KG        MG/KG                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ENDOCRINE SYSTEM - cont                                                                                                             
      C-Cell, Adenoma                                 10 (20%)      1 (3%)       2 (6%)       7 (14%)                               
      C-Cell, Adenoma, Multiple                                                               1 (2%)                                
      Follicular Cell, Adenoma                         1 (2%)       2 (6%)                    1 (2%)                                
      Follicular Cell, Carcinoma                                                              1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Clitoral Gland                                     (49)         (50)         (50)         (50)                                   
      Adenoma                                          1 (2%)       3 (6%)       3 (6%)                                             
      Carcinoma                                                                  1 (2%)       2 (4%)                                
      Bilateral, Adenoma                                                         1 (2%)                                             
   Ovary                                              (50)         (35)         (33)         (50)                                   
   Uterus                                             (50)         (35)         (33)         (50)                                   
      Fibroma                                          1 (2%)                                                                       
      Polyp Stromal                                    2 (4%)       1 (3%)       1 (3%)       3 (6%)                                
      Sarcoma Stromal                                               1 (3%)       1 (3%)                                             
   Vagina                                             (1)          (1)          (1)                                                 
      Squamous Cell Carcinoma                                                    1 (100%)                                           
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (50)         (35)         (33)         (48)                                   
   Lymph Node                                         (45)         (32)         (27)         (43)                                   
   Lymph Node, Mandibular                             (50)         (35)         (33)         (50)                                   
   Lymph Node, Mesenteric                             (49)         (35)         (33)         (48)                                   
   Spleen                                             (50)         (35)         (33)         (50)                                   
   Thymus                                             (49)         (35)         (31)         (49)                                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Mammary Gland                                      (50)         (35)         (33)         (50)                                   
      Carcinoma                                        1 (2%)       1 (3%)                    1 (2%)                                
      Fibroadenoma                                    12 (24%)      4 (11%)      8 (24%)      6 (12%)                               
      Fibroadenoma, Multiple                           4 (8%)                                 3 (6%)                                
   Skin                                               (50)         (50)         (50)         (50)                                   
      Pinna, Squamous Cell Papilloma                   1 (2%)                                                                       
      Subcutaneous Tissue, Lipoma                                   1 (2%)                                                          
      Subcutaneous Tissue, Sarcoma                                               1 (2%)                                             
      Subcutaneous Tissue, Schwannoma Malignant        1 (2%)                                                                       

                                                             Page   3                                                               
NTP Experiment-Test: 05188-05  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                       SODIUM XYLENESULFONATE                                  Date: 04/04/96  
Route: SKIN APPLICATION                                                                                           Time: 04:28:16  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS FEMALE                   0 MG/KG      60 MG/KG     120          240                                       
                                                                             MG/KG        MG/KG                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Bone                                               (50)         (35)         (33)         (48)                                   
      Humerus, Osteosarcoma                            1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (50)         (35)         (33)         (50)                                   
      Astrocytoma Malignant                            1 (2%)       1 (3%)                                                          
      Carcinoma, Metastatic, Pituitary Gland           1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (50)         (35)         (33)         (50)                                   
      Alveolar/Bronchiolar Adenoma                     1 (2%)                                                                       
      Osteosarcoma, Metastatic, Bone                   1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Zymbal's Gland                                                                            (1)                                    
      Carcinoma                                                                               1 (100%)                              
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (50)         (35)         (33)         (50)                                   
      Lipoma                                                        1 (3%)                                                          
   Urinary Bladder                                    (50)         (35)         (33)         (50)                                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SYSTEMIC LESIONS                                                                                                                   

   Multiple Organs                                   *(50)        *(50)        *(50)        *(50)                                   
      Leukemia Mononuclear                            17 (34%)      5 (10%)      9 (18%)     10 (20%)                               
      Mesothelioma Benign                                                                     1 (2%)                                
____________________________________________________________________________________________________________________________________

                                                                                                                                    
     *   Number of animals with any tissue examined microscopically                                                                 

                                                             Page   4                                                               
NTP Experiment-Test: 05188-05  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                       SODIUM XYLENESULFONATE                                  Date: 04/04/96  
Route: SKIN APPLICATION                                                                                           Time: 04:28:16  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS FEMALE                   0 MG/KG      60 MG/KG     120          240                                       
                                                                             MG/KG        MG/KG                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
TUMOR SUMMARY                                                                                                                       
                                                                                                                                    
   Total Animals with Primary Neoplasms (b)            45          25          27          41                                       
     Total Primary Neoplasms                           93          40          50          70                                       
                                                                                                                                    
   Total Animals with Benign Neoplasms                 40          23          26          33                                       
     Total Benign Neoplasms                            69          32          37          55                                       
                                                                                                                                    
   Total Animals with Malignant Neoplasms              23           8          11          15                                       
     Total Malignant Neoplasms                         24           8          13          15                                       
                                                                                                                                    
   Total Animals with Metastatic Neoplasms              2                                                                           
     Total Metastatic Neoplasm                          2                                                                           
                                                                                                                                    
   Total Animals with Malignant Neoplasms                                                                                           
   Uncertain Primary Site                                                                                                           
                                                                                                                                    
   Total Animals with Neoplasms Uncertain-                                                                                          
   Benign or Malignant                                                                                                              
     Total Uncertain Neoplasms                                                                                                      
                                                                                                                                    

____________________________________________________________________________________________________________________________________
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Primary tumors: all tumors except metastatic tumors                                                                              

                                                             Page   5                                                               
NTP Experiment-Test: 05188-05  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                       SODIUM XYLENESULFONATE                                  Date: 04/04/96  
Route: SKIN APPLICATION                                                                                           Time: 04:28:16  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     0 MG/KG      60 MG/KG     120          240                                       
                                                                             MG/KG        MG/KG                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
DISPOSITION SUMMARY                                                                                                                 

  Animals Initially in Study                          50           50           50           50                                     
  Early Deaths                                                                                                                      
    Natural Death                                     15            8           19           10                                     
    Moribund Sacrifice                                28           25           22           30                                     
  Survivors                                                                                                                         
    Terminal Sacrifice                                 7           17            9           10                                     

  Animals Examined Microscopically                    50           50           50           50                                     
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Intestine Large, Colon                             (50)         (33)         (41)         (50)                                   
   Intestine Large, Cecum                             (50)         (33)         (41)         (50)                                   
   Intestine Small, Duodenum                          (50)         (33)         (41)         (50)                                   
      Carcinoma, Metastatic, Kidney                                              1 (2%)                                             
      Leiomyosarcoma, Metastatic, Stomach,                                                                                          
          Forestomach                                                            1 (2%)                                             
      Sarcoma, Metastatic, Mesentery                                             1 (2%)                                             
   Intestine Small, Jejunum                           (50)         (33)         (41)         (50)                                   
      Carcinoma                                        1 (2%)                                 1 (2%)                                
      Leiomyosarcoma                                                1 (3%)                                                          
      Leiomyosarcoma, Metastatic, Stomach,                                                                                          
          Forestomach                                                            1 (2%)                                             
   Intestine Small, Ileum                             (50)         (33)         (41)         (50)                                   
   Liver                                              (50)         (45)         (47)         (50)                                   
      Carcinoma, Metastatic, Kidney                                 1 (2%)                                                          
      Hepatocellular Carcinoma                                      1 (2%)                                                          
      Histiocytic Sarcoma                                                        1 (2%)       1 (2%)                                
      Leiomyosarcoma, Metastatic, Intestine Small,                                                                                  
           Jejunum                                                  1 (2%)                                                          
      Leiomyosarcoma, Metastatic, Stomach,                                                                                          
          Forestomach                                                            1 (2%)                                             
   Mesentery                                          (8)          (7)          (9)          (8)                                    
      Carcinoma, Metastatic, Kidney                                 1 (14%)      1 (11%)                                            
      Histiocytic Sarcoma                                                                     1 (13%)                               
      Leiomyosarcoma, Metastatic, Intestine Small,                                                                                  
           Jejunum                                                  1 (14%)                                                         
      Leiomyosarcoma, Metastatic, Stomach,                                                                                          
          Forestomach                                                            1 (11%)                                            
      Sarcoma                                                                    1 (11%)                                            
   Oral Mucosa                                        (2)          (1)          (3)          (6)                                    
      Gingival, Squamous Cell Carcinoma                1 (50%)                                1 (17%)                               
      Pharyngeal, Squamous Cell Carcinoma                                                     1 (17%)                               
   Pancreas                                           (50)         (33)         (41)         (50)                                   

                                                             Page   6                                                               
NTP Experiment-Test: 05188-05  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                       SODIUM XYLENESULFONATE                                  Date: 04/04/96  
Route: SKIN APPLICATION                                                                                           Time: 04:28:16  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     0 MG/KG      60 MG/KG     120          240                                       
                                                                             MG/KG        MG/KG                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ALIMENTARY SYSTEM - cont                                                                                                            
      Carcinoma, Metastatic, Kidney                                 1 (3%)       1 (2%)                                             
      Histiocytic Sarcoma                                                        1 (2%)       1 (2%)                                
      Leiomyosarcoma, Metastatic, Intestine Small,                                                                                  
           Jejunum                                                  1 (3%)                                                          
      Leiomyosarcoma, Metastatic, Stomach,                                                                                          
          Forestomach                                                            1 (2%)                                             
      Mixed Tumor Benign                                                         1 (2%)                                             
   Stomach, Forestomach                               (50)         (33)         (41)         (50)                                   
      Leiomyosarcoma                                                             1 (2%)                                             
   Stomach, Glandular                                 (50)         (33)         (41)         (50)                                   
      Leiomyosarcoma                                                             1 (2%)                                             
      Sarcoma, Metastatic, Mesentery                                             1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Heart                                              (50)         (33)         (41)         (50)                                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Cortex                                     (50)         (33)         (41)         (50)                                   
      Adenoma                                          1 (2%)                                                                       
      Histiocytic Sarcoma                                                                     1 (2%)                                
      Leiomyosarcoma, Metastatic, Stomach,                                                                                          
          Forestomach                                                            1 (2%)                                             
   Adrenal Medulla                                    (50)         (33)         (41)         (50)                                   
      Pheochromocytoma Malignant                                                              1 (2%)                                
      Pheochromocytoma Benign                          8 (16%)      5 (15%)      3 (7%)       9 (18%)                               
   Islets, Pancreatic                                 (50)         (33)         (41)         (50)                                   
      Adenoma                                          5 (10%)                                3 (6%)                                
      Carcinoma                                                     1 (3%)                    1 (2%)                                
      Carcinoma, Metastatic, Kidney                                 1 (3%)       1 (2%)                                             
      Leiomyosarcoma, Metastatic, Intestine Small,                                                                                  
           Jejunum                                                  1 (3%)                                                          
   Pituitary Gland                                    (50)         (33)         (41)         (50)                                   
      Adenoma, Multiple                                1 (2%)                                                                       
      Pars Distalis, Adenoma                          34 (68%)     26 (79%)     30 (73%)     31 (62%)                               
      Pars Distalis, Adenoma, Multiple                 9 (18%)      1 (3%)       4 (10%)      5 (10%)                               
      Pars Distalis, Carcinoma                         1 (2%)                                                                       
      Pars Distalis, Craniopharyngioma                                                        1 (2%)                                
   Thyroid Gland                                      (50)         (33)         (41)         (50)                                   
      Bilateral, C-Cell, Adenoma                       1 (2%)                                 1 (2%)                                
      Bilateral, C-Cell, Carcinoma                                                            1 (2%)                                
      C-Cell, Adenoma                                  8 (16%)      3 (9%)       1 (2%)       5 (10%)                               
      Follicular Cell, Carcinoma                       1 (2%)                    1 (2%)       1 (2%)                                
____________________________________________________________________________________________________________________________________

                                                             Page   7                                                               
NTP Experiment-Test: 05188-05  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                       SODIUM XYLENESULFONATE                                  Date: 04/04/96  
Route: SKIN APPLICATION                                                                                           Time: 04:28:16  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     0 MG/KG      60 MG/KG     120          240                                       
                                                                             MG/KG        MG/KG                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   Peritoneum                                         (3)          (1)                       (2)                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Epididymis                                         (50)         (33)         (41)         (50)                                   
   Preputial Gland                                    (50)         (33)         (40)         (50)                                   
      Adenoma                                          1 (2%)                    1 (3%)                                             
      Carcinoma                                                                  1 (3%)                                             
   Prostate                                           (50)         (33)         (41)         (50)                                   
   Seminal Vesicle                                    (50)         (33)         (41)         (50)                                   
      Carcinoma, Metastatic, Kidney                                 1 (3%)       1 (2%)                                             
      Leiomyosarcoma, Metastatic, Intestine Small,                                                                                  
           Jejunum                                                  1 (3%)                                                          
      Leiomyosarcoma, Metastatic, Stomach,                                                                                          
          Forestomach                                                            1 (2%)                                             
   Testes                                             (50)         (33)         (41)         (50)                                   
      Bilateral, Interstitial Cell, Adenoma           11 (22%)      2 (6%)       5 (12%)     17 (34%)                               
      Interstitial Cell, Adenoma                      13 (26%)      6 (18%)      8 (20%)     13 (26%)                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (50)         (32)         (41)         (50)                                   
      Histiocytic Sarcoma                                                        1 (2%)       1 (2%)                                
   Lymph Node                                         (41)         (25)         (31)         (41)                                   
      Mediastinal, Carcinoma, Metastatic, Kidney                    1 (4%)       1 (3%)                                             
      Mediastinal, Histiocytic Sarcoma                                           1 (3%)       1 (2%)                                
      Renal, Carcinoma, Metastatic, Kidney                                       1 (3%)                                             
   Lymph Node, Mandibular                             (50)         (33)         (40)         (49)                                   
      Histiocytic Sarcoma                                                        1 (3%)                                             
   Lymph Node, Mesenteric                             (50)         (33)         (41)         (50)                                   
      Carcinoma, Metastatic, Kidney                                 1 (3%)       1 (2%)                                             
      Leiomyosarcoma, Metastatic, Intestine Small,                                                                                  
           Jejunum                                                  1 (3%)                                                          
   Spleen                                             (50)         (46)         (47)         (50)                                   
      Fibroma                                                       1 (2%)                                                          
      Histiocytic Sarcoma                                                        1 (2%)       1 (2%)                                
      Leiomyosarcoma, Metastatic, Stomach,                                                                                          
          Forestomach                                                            1 (2%)                                             
   Thymus                                             (46)         (31)         (41)         (50)                                   
      Thymoma Benign                                                                          1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    

                                                             Page   8                                                               
NTP Experiment-Test: 05188-05  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                       SODIUM XYLENESULFONATE                                  Date: 04/04/96  
Route: SKIN APPLICATION                                                                                           Time: 04:28:16  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     0 MG/KG      60 MG/KG     120          240                                       
                                                                             MG/KG        MG/KG                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Mammary Gland                                      (50)         (32)         (40)         (50)                                   
      Carcinoma                                                     1 (3%)                                                          
      Fibroadenoma                                     1 (2%)                                                                       
   Skin                                               (50)         (50)         (50)         (50)                                   
      Basal Cell Adenoma                                                                      1 (2%)                                
      Keratoacanthoma                                               1 (2%)       1 (2%)                                             
      Squamous Cell Papilloma                                                    1 (2%)       1 (2%)                                
      Sebaceous Gland, Skin, Site of Application,                                                                                   
           Carcinoma                                   1 (2%)                                                                       
      Skin, Site of Application, Basal Cell Adenoma                 1 (2%)       1 (2%)                                             
      Subcutaneous Tissue, Fibroma                                  1 (2%)       1 (2%)       3 (6%)                                
      Subcutaneous Tissue, Histiocytic Sarcoma                                                1 (2%)                                
      Subcutaneous Tissue, Schwannoma Malignant                                  1 (2%)                                             
      Subcutaneous Tissue, Pinna, Melanoma                                                                                          
          Malignant                                    1 (2%)                                                                       
      Subcutaneous Tissue, Skin, Site of                                                                                            
          Application, Fibroma, Multiple               1 (2%)                                                                       
      Subcutaneous Tissue, Skin, Site of                                                                                            
          Application, Fibrous Histiocytoma                         1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Bone                                               (50)         (32)         (41)         (50)                                   
      Osteosarcoma                                                               1 (2%)                                             
      Rib, Osteosarcoma                                             1 (3%)                                                          
   Skeletal Muscle                                                 (3)          (2)                                                 
      Carcinoma, Metastatic, Kidney                                 1 (33%)      1 (50%)                                            
      Histiocytic Sarcoma                                                        1 (50%)                                            
      Leiomyosarcoma, Metastatic, Intestine Small,                                                                                  
           Jejunum                                                  1 (33%)                                                         
      Osteosarcoma, Metastatic, Bone                                1 (33%)                                                         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (50)         (33)         (41)         (50)                                   
      Astrocytoma Malignant                            1 (2%)       1 (3%)                                                          
      Carcinoma, Metastatic, Pituitary Gland           1 (2%)                                                                       
      Oligodendroglioma Malignant                                                1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    

                                                             Page   9                                                               
NTP Experiment-Test: 05188-05  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                       SODIUM XYLENESULFONATE                                  Date: 04/04/96  
Route: SKIN APPLICATION                                                                                           Time: 04:28:16  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     0 MG/KG      60 MG/KG     120          240                                       
                                                                             MG/KG        MG/KG                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (50)         (33)         (41)         (50)                                   
      Alveolar/Bronchiolar Adenoma                     1 (2%)                                                                       
      Alveolar/Bronchiolar Carcinoma                   2 (4%)                                                                       
      Carcinoma, Metastatic, Kidney                                 1 (3%)       1 (2%)                                             
      Carcinoma, Metastatic, Skin                      1 (2%)                                                                       
      Histiocytic Sarcoma                                                        1 (2%)       1 (2%)                                
      Leiomyosarcoma, Metastatic, Intestine Small,                                                                                  
           Jejunum                                                  1 (3%)                                                          
      Osteosarcoma, Metastatic, Bone                                             1 (2%)                                             
      Mediastinum, Osteosarcoma, Metastatic, Bone                   1 (3%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Harderian Gland                                    (1)          (1)                       (1)                                    
      Squamous Cell Carcinoma, Metastatic, Oral                                                                                     
          Mucosa                                                                              1 (100%)                              
   Zymbal's Gland                                                               (2)          (2)                                    
      Adenoma                                                                    1 (50%)                                            
      Carcinoma                                                                  1 (50%)      2 (100%)                              
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (50)         (33)         (41)         (50)                                   
      Adenoma, Tubular                                 1 (2%)                                                                       
      Carcinoma, Metastatic, Kidney                                 1 (3%)                                                          
      Sarcoma                                                       1 (3%)                                                          
      Renal Tubule, Adenoma                            1 (2%)                                 1 (2%)                                
      Renal Tubule, Carcinoma                                       1 (3%)       1 (2%)                                             
   Urinary Bladder                                    (50)         (33)         (41)         (50)                                   
      Transitional Epithelium, Carcinoma                                         1 (2%)                                             
      Transitional Epithelium, Papilloma               1 (2%)                                                                       
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SYSTEMIC LESIONS                                                                                                                   

   Multiple Organs                                   *(50)        *(50)        *(50)        *(50)                                   
      Histiocytic Sarcoma                                                        1 (2%)       1 (2%)                                
      Leukemia Mononuclear                            12 (24%)     24 (48%)     15 (30%)     25 (50%)                               
      Mesothelioma Malignant                           1 (2%)                                                                       
____________________________________________________________________________________________________________________________________

                                                                                                                                    
     *   Number of animals with any tissue examined microscopically                                                                 

                                                             Page  10                                                               
NTP Experiment-Test: 05188-05  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                       SODIUM XYLENESULFONATE                                  Date: 04/04/96  
Route: SKIN APPLICATION                                                                                           Time: 04:28:16  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     0 MG/KG      60 MG/KG     120          240                                       
                                                                             MG/KG        MG/KG                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
TUMOR SUMMARY                                                                                                                       
                                                                                                                                    
   Total Animals with Primary Neoplasms (b)            50          45          46          49                                       
     Total Primary Neoplasms                          120          80          85         127                                       
                                                                                                                                    
   Total Animals with Benign Neoplasms                 49          29          39          49                                       
     Total Benign Neoplasms                            98          47          58          92                                       
                                                                                                                                    
   Total Animals with Malignant Neoplasms              18          28          25          30                                       
     Total Malignant Neoplasms                         22          33          27          35                                       
                                                                                                                                    
   Total Animals with Metastatic Neoplasms              7           4           4           3                                       
     Total Metastatic Neoplasm                         42          33          21          22                                       
                                                                                                                                    
   Total Animals with Malignant Neoplasms               5           1                       2                                       
   Uncertain Primary Site                                                                                                           
                                                                                                                                    
   Total Animals with Neoplasms Uncertain-                                                                                          
   Benign or Malignant                                                                                                              
     Total Uncertain Neoplasms                                                                                                      
                                                                                                                                    

____________________________________________________________________________________________________________________________________
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Primary tumors: all tumors except metastatic tumors                                                                              

                                                             Page  11                                                               
                             ------------------------------------------------------------                                           
                             ----------              END OF REPORT             ----------                                           
                             ------------------------------------------------------------