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TDMS Study 05188-05 Pathology Tables

NTP                                        STATISTICAL ANALYSIS OF PRIMARY TUMORS                              REPORT: PEIRPT08     
LAB: Battelle Columbus                                   SODIUM XYLENESULFONATE                                DATE: 04/04/96       
EXPERIMENT: 05188 TEST: 05                                                                                     TIME: 04:41:38       
TEST TYPE:  CHRONIC                             CAGES FROM 0000 TO LAST CAGE                                   PAGE:       1        
CONT: N01-ES-05293                              ROUTE: SKIN APPLICATION                                        NTP C#: 55403D       
PATHOLOGIST: TOFT, J.                                                                                          CAS: 1300-72-7       
------------------------------------------------------------------------------------------------------------------------------------
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    

               REASONS FOR REMOVAL:    ALL                                                                                          
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
               REMOVAL DATE RANGE:     ALL                                                                                          
                                                                                                                                    
               TREATMENT GROUPS:       INCLUDE ALL                                                                                  
NTP                                        STATISTICAL ANALYSIS OF PRIMARY TUMORS                              REPORT: PEIRPT08     
LAB: Battelle Columbus                                   SODIUM XYLENESULFONATE                                DATE: 04/04/96       
EXPERIMENT: 05188 TEST: 05                                                                                     TIME: 04:41:38       
TEST TYPE:  CHRONIC                             CAGES FROM 0000 TO LAST CAGE                                                        
CONT: N01-ES-05293                              ROUTE: SKIN APPLICATION                                        NTP C#: 55403D       
PATHOLOGIST: TOFT, J.                                                                                          CAS: 1300-72-7       




                                                    RATS(FISCHER344)
                                              ----------------------------
             FOR ALL DOSES THE TUMOR RATES IN THE FOLLOWING TISSUES/ORGANS ARE BASED ON NUMBER OF TISSUES EXAMINED.
             IN OTHER TISSUES/ORGANS, RATES ARE BASED ON NUMBER OF ANIMALS NECROPSIED.
                                                                    

                                                    ----------------

                                                    Adrenal Cortex
                                                    Adrenal Medulla
                                                    Bone Marrow
                                                    Brain
                                                    Clitoral Gland
                                                    Clitoral/Preputial Gland
                                                    Epididymis
                                                    Heart
                                                    Islets, Pancreatic
                                                    Kidney
                                                    Liver
                                                    Lung
                                                    Nose
                                                    Ovary
                                                    Pancreas
                                                    Parathyroid Gland
                                                    Pituitary Gland
                                                    Preputial Gland
                                                    Prostate
                                                    Salivary Glands
                                                    Spleen
                                                    Testes
                                                    Thymus
                                                    Thyroid Gland
                                                    Urinary Bladder
NTP                                        STATISTICAL ANALYSIS OF PRIMARY TUMORS                              REPORT: PEIRPT08     
LAB: Battelle Columbus                                   SODIUM XYLENESULFONATE                                DATE: 04/04/96       
EXPERIMENT: 05188 TEST: 05                                                                                     TIME: 04:41:38       
TEST TYPE:  CHRONIC                             CAGES FROM 0000 TO LAST CAGE                                                        
CONT: N01-ES-05293                              ROUTE: SKIN APPLICATION                                        NTP C#: 55403D       
PATHOLOGIST: TOFT, J.                                                                                          CAS: 1300-72-7       




                                     SUMMARY OF STATISTICALLY SIGNIFICANT (P<=.05) RESULTS
                                     IN THE ANALYSIS OF THE STUDY OF SODIUM XYLENESULFONATE

              ====================================================================================================

                                                           MALE RATS
                                                          -------------
                  ORGAN                               MORPHOLOGY
                 -------                             ------------

              Islets, Pancreatic            Adenoma
                                            Carcinoma or Adenoma
              Lung                          Alveolar/Bronchiolar Carcinoma or Alveolar/Bronchiolar Adenoma
              Pituitary Gland: Pars Distalis or Unspecified Site
                                            Adenoma
                                            Carcinoma or Adenoma
              Testes                        Adenoma
              Thyroid Gland: C-Cell         Adenoma
                                            Carcinoma or Adenoma
              All Organs                    Leukemia: Lymphocytic, Monocytic, Mononuclear, or Undifferentiated
                                            Benign Tumors
                                            Malignant Tumors

              ====================================================================================================

                                                           FEMALE RATS
                                                          -------------
                  ORGAN                               MORPHOLOGY
                 -------                             ------------

              Mammary Gland                 Fibroadenoma
                                            Fibroma, Fibroadenoma, Carcinoma, or Adenoma
              Pituitary Gland: Pars Distalis or Unspecified Site
                                            Carcinoma or Adenoma
              Thyroid Gland: C-Cell         Adenoma
                                            Carcinoma or Adenoma
              Thyroid Gland: Follicular Cell
                                            Adenoma
                                            Carcinoma or Adenoma
              All Organs                    Leukemia: Lymphocytic, Monocytic, Mononuclear, or Undifferentiated
                                            Benign Tumors
                                            Malignant Tumors
                                            Malignant and Benign Tumors

              ====================================================================================================
         DATE: 04/04/96                     EXPERIMENT: 05188 TEST: 05                                                 PAGE   1
                         STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- SODIUM XYLENESULFONATE

                                                 MALE TERMINAL SACRIFICE AT 105 WEEKS
                                                 FEMALE TERMINAL SACRIFICE AT 106 WEEKS

|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   0 MG/KG      60 MG/KG     120          240       |   0 MG/KG      60 MG/KG     120          240       |
|                       |                             MG/KG        MG/KG     |                             MG/KG        MG/KG     |
|=================================================================================================================================|
|                                                                                                                                 |
|Adrenal Medulla                                                                                                                  |
|     Pheochromocytoma Benign                                                                                                     |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  8/50 (16%)   5/33 (15%)   3/41 (7%)    9/50 (18%) |  1/50 (2%)    0/35 (0%)    1/33 (3%)    2/50 (4%)  |
|ADJUSTED (b)           |  44.8%        24.4%        14.4%        49.7%      |   4.5%         0.0%         4.5%         9.9%      |
|TERMINAL (d)           |  1/7 (14%)    0/0          0/0          3/10 (30%) |  1/22 (5%)    0/1 (0%)     0/0          1/16 (6%)  |
|FIRST INCIDENCE (DAYS) |   554          623          594          642       |   736 (T)      ---          706          651       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.506N     P=0.317N     P=0.234N     P=0.482N   |  P=0.247      P=0.987N     P=0.467      P=0.399    |
|INCIDENTAL TUMOR       |  P=0.463      P=0.474      P=0.194N     P=0.428    |  P=0.268      P=0.987N     P=0.500      P=0.416    |
|LOGISTIC REGRESSION    |  P=0.518N     P=0.355      P=0.277N     P=0.557    |  P=0.272      P=0.987N     P=0.343      P=0.443    |
|COCHRAN-ARMITAGE       |  P=0.459                                           |  P=0.280                                           |
|FISHER EXACT           |               P=0.586N     P=0.174N     P=0.500    |               P=0.588N     P=0.640      P=0.500    |
|=================================================================================================================================|
|                                                                                                                                 |
|Adrenal Medulla                                                                                                                  |
|     Pheochromocytoma: Benign, Complex, Malignant, NOS                                                                           |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  8/50 (16%)   5/33 (15%)   3/41 (7%)   10/50 (20%) |  1/50 (2%)    0/35 (0%)    1/33 (3%)    2/50 (4%)  |
|ADJUSTED (b)           |  44.8%        24.4%        14.4%        51.0%      |   4.5%         0.0%         4.5%         9.9%      |
|TERMINAL (d)           |  1/7 (14%)    0/0          0/0          3/10 (30%) |  1/22 (5%)    0/1 (0%)     0/0          1/16 (6%)  |
|FIRST INCIDENCE (DAYS) |   554          623          594          561       |   736 (T)      ---          706          651       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.482      P=0.317N     P=0.234N     P=0.580N   |  P=0.247      P=0.987N     P=0.467      P=0.399    |
|INCIDENTAL TUMOR       |  P=0.343      P=0.474      P=0.194N     P=0.321    |  P=0.268      P=0.987N     P=0.500      P=0.416    |
|LOGISTIC REGRESSION    |  P=0.457      P=0.355      P=0.277N     P=0.429    |  P=0.272      P=0.987N     P=0.343      P=0.443    |
|COCHRAN-ARMITAGE       |  P=0.345                                           |  P=0.280                                           |
|FISHER EXACT           |               P=0.586N     P=0.174N     P=0.398    |               P=0.588N     P=0.640      P=0.500    |
|=================================================================================================================================|
         DATE: 04/04/96                     EXPERIMENT: 05188 TEST: 05                                                 PAGE   2
                         STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- SODIUM XYLENESULFONATE

                                                 MALE TERMINAL SACRIFICE AT 105 WEEKS
                                                 FEMALE TERMINAL SACRIFICE AT 106 WEEKS

|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   0 MG/KG      60 MG/KG     120          240       |   0 MG/KG      60 MG/KG     120          240       |
|                       |                             MG/KG        MG/KG     |                             MG/KG        MG/KG     |
|=================================================================================================================================|
|                                                                                                                                 |
|Clitoral/Preputial Gland                                                                                                         |
|     Adenoma                                                                                                                     |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  1/50 (2%)    0/33 (0%)    1/40 (3%)    0/50 (0%)  |  1/49 (2%)    3/50 (6%)    4/50 (8%)    0/50 (0%)  |
|ADJUSTED (b)           |   6.7%         0.0%         2.3%         0.0%      |   4.5%        12.7%        18.6%         0.0%      |
|TERMINAL (d)           |  0/7 (0%)     0/0          0/0          0/10 (0%)  |  1/22 (5%)    1/16 (6%)    2/17 (12%)   0/16 (0%)  |
|FIRST INCIDENCE (DAYS) |   707          ---          527          ---       |   736 (T)      622          602          ---       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.395N     P=0.487N     P=0.728      P=0.464N   |  P=0.388N     P=0.220      P=0.124      P=0.564N   |
|INCIDENTAL TUMOR       |  P=0.379N     P=0.619N     P=0.742      P=0.545N   |  P=0.294N     P=0.396      P=0.172      P=0.564N   |
|LOGISTIC REGRESSION    |  P=0.390N     P=0.727N     P=0.722      P=0.478N   |  P=0.340N     P=0.263      P=0.146      P=0.564N   |
|COCHRAN-ARMITAGE       |  P=0.390N                                          |  P=0.307N                                          |
|FISHER EXACT           |               P=0.602N     P=0.694      P=0.500N   |               P=0.316      P=0.187      P=0.495N   |
|=================================================================================================================================|
|                                                                                                                                 |
|Clitoral/Preputial Gland                                                                                                         |
|     Carcinoma                                                                                                                   |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  0/50 (0%)    0/33 (0%)    1/40 (3%)    0/50 (0%)  |  0/49 (0%)    0/50 (0%)    1/50 (2%)    2/50 (4%)  |
|ADJUSTED (b)           |   0.0%         0.0%         7.1%         0.0%      |   0.0%         0.0%         2.2%         9.1%      |
|TERMINAL (d)           |  0/7 (0%)     0/0          0/0          0/10 (0%)  |  0/22 (0%)    0/16 (0%)    0/17 (0%)    1/16 (6%)  |
|FIRST INCIDENCE (DAYS) |   ---          ---          700          ---       |   ---          ---          492          611       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.702        (e)        P=0.461        (e)      |  P=0.066        (e)        P=0.528      P=0.199    |
|INCIDENTAL TUMOR       |  P=0.677        (e)        P=0.468        (e)      |  P=0.070        (e)        P=0.540      P=0.282    |
|LOGISTIC REGRESSION    |  P=0.714        (e)        P=0.341        (e)      |  P=0.073        (e)        P=0.437      P=0.223    |
|COCHRAN-ARMITAGE       |  P=0.697                                           |  P=0.071                                           |
|FISHER EXACT           |                 (e)        P=0.444        (e)      |                 (e)        P=0.505      P=0.253    |
|=================================================================================================================================|
         DATE: 04/04/96                     EXPERIMENT: 05188 TEST: 05                                                 PAGE   3
                         STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- SODIUM XYLENESULFONATE

                                                 MALE TERMINAL SACRIFICE AT 105 WEEKS
                                                 FEMALE TERMINAL SACRIFICE AT 106 WEEKS

|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   0 MG/KG      60 MG/KG     120          240       |   0 MG/KG      60 MG/KG     120          240       |
|                       |                             MG/KG        MG/KG     |                             MG/KG        MG/KG     |
|=================================================================================================================================|
|                                                                                                                                 |
|Clitoral/Preputial Gland                                                                                                         |
|     Carcinoma or Adenoma                                                                                                        |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  1/50 (2%)    0/33 (0%)    2/40 (5%)    0/50 (0%)  |  1/49 (2%)    3/50 (6%)    5/50 (10%)   2/50 (4%)  |
|ADJUSTED (b)           |   6.7%         0.0%         9.3%         0.0%      |   4.5%        12.7%        20.4%         9.1%      |
|TERMINAL (d)           |  0/7 (0%)     0/0          0/0          0/10 (0%)  |  1/22 (5%)    1/16 (6%)    2/17 (12%)   1/16 (6%)  |
|FIRST INCIDENCE (DAYS) |   707          ---          527          ---       |   736 (T)      622          492          611       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.442N     P=0.487N     P=0.444      P=0.464N   |  P=0.364      P=0.220      P=0.075      P=0.420    |
|INCIDENTAL TUMOR       |  P=0.444N     P=0.619N     P=0.462      P=0.545N   |  P=0.459      P=0.396      P=0.108      P=0.514    |
|LOGISTIC REGRESSION    |  P=0.430N     P=0.727N     P=0.392      P=0.478N   |  P=0.420      P=0.263      P=0.100      P=0.460    |
|COCHRAN-ARMITAGE       |  P=0.437N                                          |  P=0.445                                           |
|FISHER EXACT           |               P=0.602N     P=0.416      P=0.500N   |               P=0.316      P=0.107      P=0.508    |
|=================================================================================================================================|
|                                                                                                                                 |
|Islets, Pancreatic                                                                                                               |
|     Adenoma                                                                                                                     |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  5/50 (10%)   0/33 (0%)    0/41 (0%)    3/50 (6%)  |  0/50 (0%)    0/35 (0%)    1/33 (3%)    0/50 (0%)  |
|ADJUSTED (b)           |  20.6%         0.0%         0.0%        16.5%      |   0.0%         0.0%         5.6%         0.0%      |
|TERMINAL (d)           |  0/7 (0%)     0/0          0/0          1/10 (10%) |  0/22 (0%)    0/1 (0%)     0/0          0/16 (0%)  |
|FIRST INCIDENCE (DAYS) |   492          ---          ---          556       |   ---          ---          717          ---       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.334N     P=0.040N*    P=0.050N*    P=0.305N   |  P=0.648        (e)        P=0.434        (e)      |
|INCIDENTAL TUMOR       |  P=0.339N     P=0.068N     P=0.038N*    P=0.354N   |  P=0.695        (e)        P=0.500        (e)      |
|LOGISTIC REGRESSION    |  P=0.363N     P=0.067N     P=0.043N*    P=0.354N   |  P=0.654        (e)        P=0.170        (e)      |
|COCHRAN-ARMITAGE       |  P=0.366N                                          |  P=0.691                                           |
|FISHER EXACT           |               P=0.073N     P=0.046N*    P=0.357N   |                 (e)        P=0.398        (e)      |
|=================================================================================================================================|
         DATE: 04/04/96                     EXPERIMENT: 05188 TEST: 05                                                 PAGE   4
                         STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- SODIUM XYLENESULFONATE

                                                 MALE TERMINAL SACRIFICE AT 105 WEEKS
                                                 FEMALE TERMINAL SACRIFICE AT 106 WEEKS

|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   0 MG/KG      60 MG/KG     120          240       |   0 MG/KG      60 MG/KG     120          240       |
|                       |                             MG/KG        MG/KG     |                             MG/KG        MG/KG     |
|=================================================================================================================================|
|                                                                                                                                 |
|Islets, Pancreatic                                                                                                               |
|     Carcinoma or Adenoma                                                                                                        |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  5/50 (10%)   1/33 (3%)    0/41 (0%)    4/50 (8%)  |  1/50 (2%)    0/35 (0%)    1/33 (3%)    0/50 (0%)  |
|ADJUSTED (b)           |  20.6%         6.7%         0.0%        18.8%      |   2.8%         0.0%         5.6%         0.0%      |
|TERMINAL (d)           |  0/7 (0%)     0/0          0/0          1/10 (10%) |  0/22 (0%)    0/1 (0%)     0/0          0/16 (0%)  |
|FIRST INCIDENCE (DAYS) |   492          726          ---          556       |   605          ---          717          ---       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.452N     P=0.097N     P=0.050N*    P=0.446N   |  P=0.445N     P=0.543N     P=0.710      P=0.517N   |
|INCIDENTAL TUMOR       |  P=0.478N     P=0.209N     P=0.038N*    P=0.507N   |  P=0.355N     P=0.326N     P=0.686N     P=0.343N   |
|LOGISTIC REGRESSION    |  P=0.485N     P=0.239N     P=0.043N*    P=0.494N   |  P=0.408N     P=0.571N     P=0.622      P=0.491N   |
|COCHRAN-ARMITAGE       |  P=0.491N                                          |  P=0.397N                                          |
|FISHER EXACT           |               P=0.227N     P=0.046N*    P=0.500N   |               P=0.588N     P=0.640      P=0.500N   |
|=================================================================================================================================|
|                                                                                                                                 |
|Kidney: Renal Tubule                                                                                                             |
|     Adenoma                                                                                                                     |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  2/50 (4%)    0/33 (0%)    0/41 (0%)    1/50 (2%)  |  0/50 (0%)    0/35 (0%)    0/33 (0%)    0/50 (0%)  |
|ADJUSTED (b)           |  18.0%         0.0%         0.0%        10.0%      |   0.0%         0.0%         0.0%         0.0%      |
|TERMINAL (d)           |  1/7 (14%)    0/0          0/0          1/10 (10%) |  0/22 (0%)    0/1 (0%)     0/0          0/16 (0%)  |
|FIRST INCIDENCE (DAYS) |   658          ---          ---          735 (T)   |   ---          ---          ---          ---       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.313N     P=0.518N     P=0.528N     P=0.407N   |    (e)          (e)          (e)          (e)      |
|INCIDENTAL TUMOR       |  P=0.324N     P=0.619N     P=0.521N     P=0.443N   |    (e)          (e)          (e)          (e)      |
|LOGISTIC REGRESSION    |  P=0.362N     P=0.465N     P=0.391N     P=0.458N   |    (e)          (e)          (e)          (e)      |
|COCHRAN-ARMITAGE       |  P=0.436N                                          |    (e)                                             |
|FISHER EXACT           |               P=0.360N     P=0.299N     P=0.500N   |                 (e)          (e)          (e)      |
|=================================================================================================================================|
         DATE: 04/04/96                     EXPERIMENT: 05188 TEST: 05                                                 PAGE   5
                         STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- SODIUM XYLENESULFONATE

                                                 MALE TERMINAL SACRIFICE AT 105 WEEKS
                                                 FEMALE TERMINAL SACRIFICE AT 106 WEEKS

|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   0 MG/KG      60 MG/KG     120          240       |   0 MG/KG      60 MG/KG     120          240       |
|                       |                             MG/KG        MG/KG     |                             MG/KG        MG/KG     |
|=================================================================================================================================|
|                                                                                                                                 |
|Kidney: Renal Tubule                                                                                                             |
|     Carcinoma or Adenoma                                                                                                        |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  2/50 (4%)    1/33 (3%)    1/41 (2%)    1/50 (2%)  |  0/50 (0%)    0/35 (0%)    0/33 (0%)    0/50 (0%)  |
|ADJUSTED (b)           |  18.0%         4.5%         2.4%        10.0%      |   0.0%         0.0%         0.0%         0.0%      |
|TERMINAL (d)           |  1/7 (14%)    0/0          0/0          1/10 (10%) |  0/22 (0%)    0/1 (0%)     0/0          0/16 (0%)  |
|FIRST INCIDENCE (DAYS) |   658          656          535          735 (T)   |   ---          ---          ---          ---       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.293N     P=0.745      P=0.740      P=0.407N   |    (e)          (e)          (e)          (e)      |
|INCIDENTAL TUMOR       |  P=0.290N     P=0.624      P=0.749      P=0.443N   |    (e)          (e)          (e)          (e)      |
|LOGISTIC REGRESSION    |  P=0.360N     P=0.707      P=0.595N     P=0.458N   |    (e)          (e)          (e)          (e)      |
|COCHRAN-ARMITAGE       |  P=0.380N                                          |    (e)                                             |
|FISHER EXACT           |               P=0.653N     P=0.575N     P=0.500N   |                 (e)          (e)          (e)      |
|=================================================================================================================================|
|                                                                                                                                 |
|Lung                                                                                                                             |
|     Alveolar/Bronchiolar Carcinoma                                                                                              |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  2/50 (4%)    0/33 (0%)    0/41 (0%)    0/50 (0%)  |  0/50 (0%)    0/35 (0%)    0/33 (0%)    0/50 (0%)  |
|ADJUSTED (b)           |  10.9%         0.0%         0.0%         0.0%      |   0.0%         0.0%         0.0%         0.0%      |
|TERMINAL (d)           |  0/7 (0%)     0/0          0/0          0/10 (0%)  |  0/22 (0%)    0/1 (0%)     0/0          0/16 (0%)  |
|FIRST INCIDENCE (DAYS) |   636          ---          ---          ---       |   ---          ---          ---          ---       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.111N     P=0.240N     P=0.281N     P=0.208N   |    (e)          (e)          (e)          (e)      |
|INCIDENTAL TUMOR       |  P=0.127N     P=0.340N     P=0.259N     P=0.280N   |    (e)          (e)          (e)          (e)      |
|LOGISTIC REGRESSION    |  P=0.116N     P=0.414N     P=0.336N     P=0.233N   |    (e)          (e)          (e)          (e)      |
|COCHRAN-ARMITAGE       |  P=0.117N                                          |    (e)                                             |
|FISHER EXACT           |               P=0.360N     P=0.299N     P=0.247N   |                 (e)          (e)          (e)      |
|=================================================================================================================================|
         DATE: 04/04/96                     EXPERIMENT: 05188 TEST: 05                                                 PAGE   6
                         STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- SODIUM XYLENESULFONATE

                                                 MALE TERMINAL SACRIFICE AT 105 WEEKS
                                                 FEMALE TERMINAL SACRIFICE AT 106 WEEKS

|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   0 MG/KG      60 MG/KG     120          240       |   0 MG/KG      60 MG/KG     120          240       |
|                       |                             MG/KG        MG/KG     |                             MG/KG        MG/KG     |
|=================================================================================================================================|
|                                                                                                                                 |
|Lung                                                                                                                             |
|     Alveolar/Bronchiolar Carcinoma or Alveolar/Bronchiolar Adenoma                                                              |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  3/50 (6%)    0/33 (0%)    0/41 (0%)    0/50 (0%)  |  1/50 (2%)    0/35 (0%)    0/33 (0%)    0/50 (0%)  |
|ADJUSTED (b)           |  13.8%         0.0%         0.0%         0.0%      |   4.5%         0.0%         0.0%         0.0%      |
|TERMINAL (d)           |  0/7 (0%)     0/0          0/0          0/10 (0%)  |  1/22 (5%)    0/1 (0%)     0/0          0/16 (0%)  |
|FIRST INCIDENCE (DAYS) |   617          ---          ---          ---       |   736 (T)      ---          ---          ---       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.048N*    P=0.128N     P=0.149N     P=0.109N   |  P=0.366N     P=0.987N       (e)        P=0.564N   |
|INCIDENTAL TUMOR       |  P=0.055N     P=0.197N     P=0.136N     P=0.152N   |  P=0.366N     P=0.987N       (e)        P=0.564N   |
|LOGISTIC REGRESSION    |  P=0.050N     P=0.247N     P=0.179N     P=0.120N   |  P=0.366N     P=0.987N       (e)        P=0.564N   |
|COCHRAN-ARMITAGE       |  P=0.050N*                                         |  P=0.309N                                          |
|FISHER EXACT           |               P=0.213N     P=0.161N     P=0.121N   |               P=0.588N     P=0.602N     P=0.500N   |
|=================================================================================================================================|
|                                                                                                                                 |
|Mammary Gland                                                                                                                    |
|     Fibroadenoma                                                                                                                |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #        |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  1/50 (2%)    0/46 (0%)    0/48 (0%)    0/50 (0%)  | 16/50 (32%)   4/50 (8%)    8/50 (16%)   9/50 (18%) |
|ADJUSTED (b)           |   3.7%         0.0%         0.0%         0.0%      |  56.3%        16.3%        27.0%        41.8%      |
|TERMINAL (d)           |  0/7 (0%)     0/13 (0%)    0/7 (0%)     0/10 (0%)  | 10/22 (45%)   1/16 (6%)    0/17 (0%)    5/16 (31%) |
|FIRST INCIDENCE (DAYS) |   645          ---          ---          ---       |   490          446          441          515       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.310N     P=0.523N     P=0.515N     P=0.508N   |  P=0.345N     P=0.022N*    P=0.162N     P=0.285N   |
|INCIDENTAL TUMOR       |  P=0.320N     P=0.619N     P=0.521N     P=0.545N   |  P=0.230N     P=0.018N*    P=0.068N     P=0.191N   |
|LOGISTIC REGRESSION    |  P=0.305N     P=0.519N     P=0.511N     P=0.500N   |  P=0.208N     P=0.007N**   P=0.062N     P=0.151N   |
|COCHRAN-ARMITAGE       |  P=0.305N                                          |  P=0.170N                                          |
|FISHER EXACT           |               P=0.521N     P=0.510N     P=0.500N   |               P=0.003N**   P=0.050N     P=0.083N   |
|=================================================================================================================================|
         DATE: 04/04/96                     EXPERIMENT: 05188 TEST: 05                                                 PAGE   7
                         STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- SODIUM XYLENESULFONATE

                                                 MALE TERMINAL SACRIFICE AT 105 WEEKS
                                                 FEMALE TERMINAL SACRIFICE AT 106 WEEKS

|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   0 MG/KG      60 MG/KG     120          240       |   0 MG/KG      60 MG/KG     120          240       |
|                       |                             MG/KG        MG/KG     |                             MG/KG        MG/KG     |
|=================================================================================================================================|
|                                                                                                                                 |
|Mammary Gland                                                                                                                    |
|     Fibroma, Fibroadenoma, Carcinoma, or Adenoma                                                                                |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #        |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  1/50 (2%)    1/46 (2%)    0/48 (0%)    0/50 (0%)  | 16/50 (32%)   5/50 (10%)   8/50 (16%)  10/50 (20%) |
|ADJUSTED (b)           |   3.7%         7.1%         0.0%         0.0%      |  56.3%        19.1%        27.0%        43.1%      |
|TERMINAL (d)           |  0/7 (0%)     0/13 (0%)    0/7 (0%)     0/10 (0%)  | 10/22 (45%)   1/16 (6%)    0/17 (0%)    5/16 (31%) |
|FIRST INCIDENCE (DAYS) |   645          732          ---          ---       |   490          446          441          441       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.231N     P=0.701N     P=0.515N     P=0.508N   |  P=0.414N     P=0.046N*    P=0.162N     P=0.373N   |
|INCIDENTAL TUMOR       |  P=0.253N     P=0.624      P=0.521N     P=0.545N   |  P=0.289N     P=0.029N*    P=0.068N     P=0.273N   |
|LOGISTIC REGRESSION    |  P=0.232N     P=0.756      P=0.511N     P=0.500N   |  P=0.263N     P=0.016N*    P=0.062N     P=0.202N   |
|COCHRAN-ARMITAGE       |  P=0.234N                                          |  P=0.225N                                          |
|FISHER EXACT           |               P=0.731      P=0.510N     P=0.500N   |               P=0.006N**   P=0.050N     P=0.127N   |
|=================================================================================================================================|
|                                                                                                                                 |
|Oral Cavity (Oral Mucosa, Tongue, Pharynx, Tooth, Gingiva)                                                                       |
|     Squamous Cell Carcinoma                                                                                                     |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #        |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  1/50 (2%)    0/46 (0%)    0/48 (0%)    2/50 (4%)  |  1/50 (2%)    0/50 (0%)    0/50 (0%)    0/50 (0%)  |
|ADJUSTED (b)           |   2.3%         0.0%         0.0%        13.3%      |   4.5%         0.0%         0.0%         0.0%      |
|TERMINAL (d)           |  0/7 (0%)     0/13 (0%)    0/7 (0%)     1/10 (10%) |  1/22 (5%)    0/16 (0%)    0/17 (0%)    0/16 (0%)  |
|FIRST INCIDENCE (DAYS) |   546          ---          ---          642       |   736 (T)      ---          ---          ---       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.254      P=0.540N     P=0.519N     P=0.530    |  P=0.342N     P=0.564N     P=0.551N     P=0.564N   |
|INCIDENTAL TUMOR       |  P=0.282      P=0.500N     P=0.500N     P=0.566    |  P=0.342N     P=0.564N     P=0.551N     P=0.564N   |
|LOGISTIC REGRESSION    |  P=0.253      P=0.465N     P=0.464N     P=0.500    |  P=0.342N     P=0.564N     P=0.551N     P=0.564N   |
|COCHRAN-ARMITAGE       |  P=0.253                                           |  P=0.306N                                          |
|FISHER EXACT           |               P=0.521N     P=0.510N     P=0.500    |               P=0.500N     P=0.500N     P=0.500N   |
|=================================================================================================================================|
         DATE: 04/04/96                     EXPERIMENT: 05188 TEST: 05                                                 PAGE   8
                         STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- SODIUM XYLENESULFONATE

                                                 MALE TERMINAL SACRIFICE AT 105 WEEKS
                                                 FEMALE TERMINAL SACRIFICE AT 106 WEEKS

|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   0 MG/KG      60 MG/KG     120          240       |   0 MG/KG      60 MG/KG     120          240       |
|                       |                             MG/KG        MG/KG     |                             MG/KG        MG/KG     |
|=================================================================================================================================|
|                                                                                                                                 |
|Oral Cavity (Oral Mucosa, Tongue, Pharynx, Tooth, Gingiva)                                                                       |
|     Squamous Cell Carcinoma, Papilloma Squamous, or Papilloma                                                                   |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #        |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  1/50 (2%)    0/46 (0%)    0/48 (0%)    2/50 (4%)  |  1/50 (2%)    0/50 (0%)    0/50 (0%)    0/50 (0%)  |
|ADJUSTED (b)           |   2.3%         0.0%         0.0%        13.3%      |   4.5%         0.0%         0.0%         0.0%      |
|TERMINAL (d)           |  0/7 (0%)     0/13 (0%)    0/7 (0%)     1/10 (10%) |  1/22 (5%)    0/16 (0%)    0/17 (0%)    0/16 (0%)  |
|FIRST INCIDENCE (DAYS) |   546          ---          ---          642       |   736 (T)      ---          ---          ---       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.254      P=0.540N     P=0.519N     P=0.530    |  P=0.342N     P=0.564N     P=0.551N     P=0.564N   |
|INCIDENTAL TUMOR       |  P=0.282      P=0.500N     P=0.500N     P=0.566    |  P=0.342N     P=0.564N     P=0.551N     P=0.564N   |
|LOGISTIC REGRESSION    |  P=0.253      P=0.465N     P=0.464N     P=0.500    |  P=0.342N     P=0.564N     P=0.551N     P=0.564N   |
|COCHRAN-ARMITAGE       |  P=0.253                                           |  P=0.306N                                          |
|FISHER EXACT           |               P=0.521N     P=0.510N     P=0.500    |               P=0.500N     P=0.500N     P=0.500N   |
|=================================================================================================================================|
|                                                                                                                                 |
|Oral Mucosa                                                                                                                      |
|     Squamous Cell Carcinoma                                                                                                     |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #        |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  1/50 (2%)    0/46 (0%)    0/48 (0%)    2/50 (4%)  |  1/50 (2%)    0/50 (0%)    0/50 (0%)    0/50 (0%)  |
|ADJUSTED (b)           |   2.3%         0.0%         0.0%        13.3%      |   4.5%         0.0%         0.0%         0.0%      |
|TERMINAL (d)           |  0/7 (0%)     0/13 (0%)    0/7 (0%)     1/10 (10%) |  1/22 (5%)    0/16 (0%)    0/17 (0%)    0/16 (0%)  |
|FIRST INCIDENCE (DAYS) |   546          ---          ---          642       |   736 (T)      ---          ---          ---       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.254      P=0.540N     P=0.519N     P=0.530    |  P=0.342N     P=0.564N     P=0.551N     P=0.564N   |
|INCIDENTAL TUMOR       |  P=0.282      P=0.500N     P=0.500N     P=0.566    |  P=0.342N     P=0.564N     P=0.551N     P=0.564N   |
|LOGISTIC REGRESSION    |  P=0.253      P=0.465N     P=0.464N     P=0.500    |  P=0.342N     P=0.564N     P=0.551N     P=0.564N   |
|COCHRAN-ARMITAGE       |  P=0.253                                           |  P=0.306N                                          |
|FISHER EXACT           |               P=0.521N     P=0.510N     P=0.500    |               P=0.500N     P=0.500N     P=0.500N   |
|=================================================================================================================================|
         DATE: 04/04/96                     EXPERIMENT: 05188 TEST: 05                                                 PAGE   9
                         STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- SODIUM XYLENESULFONATE

                                                 MALE TERMINAL SACRIFICE AT 105 WEEKS
                                                 FEMALE TERMINAL SACRIFICE AT 106 WEEKS

|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   0 MG/KG      60 MG/KG     120          240       |   0 MG/KG      60 MG/KG     120          240       |
|                       |                             MG/KG        MG/KG     |                             MG/KG        MG/KG     |
|=================================================================================================================================|
|                                                                                                                                 |
|Pituitary Gland: Pars Distalis or Unspecified Site                                                                               |
|     Adenoma                                                                                                                     |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            | 44/50 (88%)  27/33 (82%)  34/41 (83%)  36/50 (72%) | 34/50 (68%)  17/35 (49%)  19/33 (58%)  29/50 (58%) |
|ADJUSTED (b)           |  97.5%        65.9%        81.4%        89.0%      |  84.5%       100.0%        48.1%        81.4%      |
|TERMINAL (d)           |  6/7 (86%)    0/0          0/0          6/10 (60%) | 16/22 (73%)   1/1 (100%)   0/0         10/16 (63%) |
|FIRST INCIDENCE (DAYS) |   441          349          439          428       |   420          486          441          396       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.146N     P=0.119N     P=0.517N     P=0.080N   |  P=0.407      P=0.431      P=0.356      P=0.429    |
|INCIDENTAL TUMOR       |  P=0.044N*    P=0.440N     P=0.458N     P=0.063N   |  P=0.302N     P=0.255N     P=0.218N     P=0.232N   |
|LOGISTIC REGRESSION    |  P=0.022N*    P=0.451N     P=0.442N     P=0.041N*  |  P=0.296N     P=0.120N     P=0.484N     P=0.243N   |
|COCHRAN-ARMITAGE       |  P=0.030N*                                         |  P=0.299N                                          |
|FISHER EXACT           |               P=0.317N     P=0.348N     P=0.039N*  |               P=0.058N     P=0.231N     P=0.204N   |
|=================================================================================================================================|
|                                                                                                                                 |
|Pituitary Gland: Pars Distalis or Unspecified Site                                                                               |
|     Carcinoma or Adenoma                                                                                                        |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            | 45/50 (90%)  27/33 (82%)  34/41 (83%)  36/50 (72%) | 35/50 (70%)  17/35 (49%)  19/33 (58%)  29/50 (58%) |
|ADJUSTED (b)           |  97.5%        65.9%        81.4%        89.0%      |  84.8%       100.0%        48.1%        81.4%      |
|TERMINAL (d)           |  6/7 (86%)    0/0          0/0          6/10 (60%) | 16/22 (73%)   1/1 (100%)   0/0         10/16 (63%) |
|FIRST INCIDENCE (DAYS) |   441          349          439          428       |   420          486          441          396       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.126N     P=0.100N     P=0.472N     P=0.066N   |  P=0.456      P=0.497      P=0.422      P=0.486    |
|INCIDENTAL TUMOR       |  P=0.024N*    P=0.304N     P=0.328N     P=0.032N*  |  P=0.244N     P=0.174N     P=0.142N     P=0.174N   |
|LOGISTIC REGRESSION    |  P=0.012N*    P=0.320N     P=0.316N     P=0.021N*  |  P=0.239N     P=0.232N     P=0.363N     P=0.182N   |
|COCHRAN-ARMITAGE       |  P=0.016N*                                         |  P=0.240N                                          |
|FISHER EXACT           |               P=0.226N     P=0.247N     P=0.020N*  |               P=0.039N*    P=0.177N     P=0.149N   |
|=================================================================================================================================|
         DATE: 04/04/96                     EXPERIMENT: 05188 TEST: 05                                                 PAGE  10
                         STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- SODIUM XYLENESULFONATE

                                                 MALE TERMINAL SACRIFICE AT 105 WEEKS
                                                 FEMALE TERMINAL SACRIFICE AT 106 WEEKS

|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   0 MG/KG      60 MG/KG     120          240       |   0 MG/KG      60 MG/KG     120          240       |
|                       |                             MG/KG        MG/KG     |                             MG/KG        MG/KG     |
|=================================================================================================================================|
|                                                                                                                                 |
|Skin                                                                                                                             |
|     Basal or Sq. Cell Carcinoma, Carcinoma, Basosq. Tumor (M or B), Basal                                                       |
|     Cell Adenoma, Adenoma, Papilloma, Sq Papilloma, Keratoacanthoma, Trichoepithelioma                                          |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #        |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  0/50 (0%)    2/46 (4%)    3/48 (6%)    2/50 (4%)  |  1/50 (2%)    0/50 (0%)    0/50 (0%)    0/50 (0%)  |
|ADJUSTED (b)           |   0.0%        11.6%        23.3%        16.0%      |   4.5%         0.0%         0.0%         0.0%      |
|TERMINAL (d)           |  0/7 (0%)     0/13 (0%)    1/7 (14%)    1/10 (10%) |  1/22 (5%)    0/16 (0%)    0/17 (0%)    0/16 (0%)  |
|FIRST INCIDENCE (DAYS) |   ---          658          666          726       |   736 (T)      ---          ---          ---       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.283      P=0.302      P=0.104      P=0.339    |  P=0.342N     P=0.564N     P=0.551N     P=0.564N   |
|INCIDENTAL TUMOR       |  P=0.231      P=0.117      P=0.110      P=0.252    |  P=0.342N     P=0.564N     P=0.551N     P=0.564N   |
|LOGISTIC REGRESSION    |  P=0.264      P=0.231      P=0.101      P=0.313    |  P=0.342N     P=0.564N     P=0.551N     P=0.564N   |
|COCHRAN-ARMITAGE       |  P=0.247                                           |  P=0.306N                                          |
|FISHER EXACT           |               P=0.227      P=0.114      P=0.247    |               P=0.500N     P=0.500N     P=0.500N   |
|=================================================================================================================================|
|                                                                                                                                 |
|Skin                                                                                                                             |
|     Fibroma                                                                                                                     |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #        |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  1/50 (2%)    1/46 (2%)    1/48 (2%)    3/50 (6%)  |  0/50 (0%)    0/50 (0%)    0/50 (0%)    0/50 (0%)  |
|ADJUSTED (b)           |   4.5%         3.7%         5.3%        18.9%      |   0.0%         0.0%         0.0%         0.0%      |
|TERMINAL (d)           |  0/7 (0%)     0/13 (0%)    0/7 (0%)     1/10 (10%) |  0/22 (0%)    0/16 (0%)    0/17 (0%)    0/16 (0%)  |
|FIRST INCIDENCE (DAYS) |   672          631          666          527       |   ---          ---          ---          ---       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.189      P=0.742      P=0.721      P=0.367    |    (e)          (e)          (e)          (e)      |
|INCIDENTAL TUMOR       |  P=0.179      P=0.660      P=0.740      P=0.329    |    (e)          (e)          (e)          (e)      |
|LOGISTIC REGRESSION    |  P=0.173      P=0.742      P=0.746      P=0.307    |    (e)          (e)          (e)          (e)      |
|COCHRAN-ARMITAGE       |  P=0.172                                           |    (e)                                             |
|FISHER EXACT           |               P=0.731      P=0.742      P=0.309    |                 (e)          (e)          (e)      |
|=================================================================================================================================|
         DATE: 04/04/96                     EXPERIMENT: 05188 TEST: 05                                                 PAGE  11
                         STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- SODIUM XYLENESULFONATE

                                                 MALE TERMINAL SACRIFICE AT 105 WEEKS
                                                 FEMALE TERMINAL SACRIFICE AT 106 WEEKS

|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   0 MG/KG      60 MG/KG     120          240       |   0 MG/KG      60 MG/KG     120          240       |
|                       |                             MG/KG        MG/KG     |                             MG/KG        MG/KG     |
|=================================================================================================================================|
|                                                                                                                                 |
|Skin                                                                                                                             |
|     Fibroma, Fibrosarcoma, Sarcoma, Myxoma, Myxosarcoma, or Fibrous Histiocytoma                                                |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #        |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  1/50 (2%)    2/46 (4%)    1/48 (2%)    3/50 (6%)  |  0/50 (0%)    0/50 (0%)    1/50 (2%)    0/50 (0%)  |
|ADJUSTED (b)           |   4.5%         8.3%         5.3%        18.9%      |   0.0%         0.0%         3.8%         0.0%      |
|TERMINAL (d)           |  0/7 (0%)     0/13 (0%)    0/7 (0%)     1/10 (10%) |  0/22 (0%)    0/16 (0%)    0/17 (0%)    0/16 (0%)  |
|FIRST INCIDENCE (DAYS) |   672          631          666          527       |   ---          ---          660          ---       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.270      P=0.470      P=0.721      P=0.367    |  P=0.669        (e)        P=0.465        (e)      |
|INCIDENTAL TUMOR       |  P=0.249      P=0.331      P=0.740      P=0.329    |  P=0.695        (e)        P=0.500        (e)      |
|LOGISTIC REGRESSION    |  P=0.249      P=0.467      P=0.746      P=0.307    |  P=0.690        (e)        P=0.498        (e)      |
|COCHRAN-ARMITAGE       |  P=0.247                                           |  P=0.694                                           |
|FISHER EXACT           |               P=0.468      P=0.742      P=0.309    |                 (e)        P=0.500        (e)      |
|=================================================================================================================================|
|                                                                                                                                 |
|Skin                                                                                                                             |
|     Squamous Cell Papilloma, Papilloma, Squamous Cell Carcinoma or Keratoacanthoma                                              |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #        |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  0/50 (0%)    1/46 (2%)    2/48 (4%)    1/50 (2%)  |  1/50 (2%)    0/50 (0%)    0/50 (0%)    0/50 (0%)  |
|ADJUSTED (b)           |   0.0%         4.8%        18.8%        10.0%      |   4.5%         0.0%         0.0%         0.0%      |
|TERMINAL (d)           |  0/7 (0%)     0/13 (0%)    1/7 (14%)    1/10 (10%) |  1/22 (5%)    0/16 (0%)    0/17 (0%)    0/16 (0%)  |
|FIRST INCIDENCE (DAYS) |   ---          658          666          735 (T)   |   736 (T)      ---          ---          ---       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.400      P=0.482      P=0.224      P=0.571    |  P=0.342N     P=0.564N     P=0.551N     P=0.564N   |
|INCIDENTAL TUMOR       |  P=0.372      P=0.381      P=0.228      P=0.571    |  P=0.342N     P=0.564N     P=0.551N     P=0.564N   |
|LOGISTIC REGRESSION    |  P=0.387      P=0.482      P=0.209      P=0.571    |  P=0.342N     P=0.564N     P=0.551N     P=0.564N   |
|COCHRAN-ARMITAGE       |  P=0.374                                           |  P=0.306N                                          |
|FISHER EXACT           |               P=0.479      P=0.237      P=0.500    |               P=0.500N     P=0.500N     P=0.500N   |
|=================================================================================================================================|
         DATE: 04/04/96                     EXPERIMENT: 05188 TEST: 05                                                 PAGE  12
                         STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- SODIUM XYLENESULFONATE

                                                 MALE TERMINAL SACRIFICE AT 105 WEEKS
                                                 FEMALE TERMINAL SACRIFICE AT 106 WEEKS

|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   0 MG/KG      60 MG/KG     120          240       |   0 MG/KG      60 MG/KG     120          240       |
|                       |                             MG/KG        MG/KG     |                             MG/KG        MG/KG     |
|=================================================================================================================================|
|                                                                                                                                 |
|Skin                                                                                                                             |
|     Squamous Cell Papilloma, Papilloma, or Keratoacanthoma                                                                      |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #        |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  0/50 (0%)    1/46 (2%)    2/48 (4%)    1/50 (2%)  |  1/50 (2%)    0/50 (0%)    0/50 (0%)    0/50 (0%)  |
|ADJUSTED (b)           |   0.0%         4.8%        18.8%        10.0%      |   4.5%         0.0%         0.0%         0.0%      |
|TERMINAL (d)           |  0/7 (0%)     0/13 (0%)    1/7 (14%)    1/10 (10%) |  1/22 (5%)    0/16 (0%)    0/17 (0%)    0/16 (0%)  |
|FIRST INCIDENCE (DAYS) |   ---          658          666          735 (T)   |   736 (T)      ---          ---          ---       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.400      P=0.482      P=0.224      P=0.571    |  P=0.342N     P=0.564N     P=0.551N     P=0.564N   |
|INCIDENTAL TUMOR       |  P=0.372      P=0.381      P=0.228      P=0.571    |  P=0.342N     P=0.564N     P=0.551N     P=0.564N   |
|LOGISTIC REGRESSION    |  P=0.387      P=0.482      P=0.209      P=0.571    |  P=0.342N     P=0.564N     P=0.551N     P=0.564N   |
|COCHRAN-ARMITAGE       |  P=0.374                                           |  P=0.306N                                          |
|FISHER EXACT           |               P=0.479      P=0.237      P=0.500    |               P=0.500N     P=0.500N     P=0.500N   |
|=================================================================================================================================|
|                                                                                                                                 |
|Testes                                                                                                                           |
|     Adenoma                                                                                                                     |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            | 24/50 (48%)   8/33 (24%)  13/41 (32%)  30/50 (60%) |                                                    |
|ADJUSTED (b)           |  94.8%        32.8%        50.8%        95.7%      |                                                    |
|TERMINAL (d)           |  6/7 (86%)    0/0          0/0          9/10 (90%) |                                                    |
|FIRST INCIDENCE (DAYS) |   534          541          535          428       |                                                    |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.209      P=0.027N*    P=0.339N     P=0.484    |                                                    |
|INCIDENTAL TUMOR       |  P=0.089      P=0.210N     P=0.266N     P=0.173    |                                                    |
|LOGISTIC REGRESSION    |  P=0.055      P=0.135N     P=0.185N     P=0.137    |                                                    |
|COCHRAN-ARMITAGE       |  P=0.046 *                                         |                                                    |
|FISHER EXACT           |               P=0.025N*    P=0.087N     P=0.158    |                                                    |
|=================================================================================================================================|
         DATE: 04/04/96                     EXPERIMENT: 05188 TEST: 05                                                 PAGE  13
                         STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- SODIUM XYLENESULFONATE

                                                 MALE TERMINAL SACRIFICE AT 105 WEEKS
                                                 FEMALE TERMINAL SACRIFICE AT 106 WEEKS

|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   0 MG/KG      60 MG/KG     120          240       |   0 MG/KG      60 MG/KG     120          240       |
|                       |                             MG/KG        MG/KG     |                             MG/KG        MG/KG     |
|=================================================================================================================================|
|                                                                                                                                 |
|Thyroid Gland: C-Cell                                                                                                            |
|     Adenoma                                                                                                                     |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  9/50 (18%)   3/33 (9%)    1/41 (2%)    6/50 (12%) | 10/50 (20%)   1/35 (3%)    2/33 (6%)    8/50 (16%) |
|ADJUSTED (b)           |  54.2%        10.1%         3.4%        37.4%      |  39.3%         4.2%         5.9%        40.6%      |
|TERMINAL (d)           |  2/7 (29%)    0/0          0/0          2/10 (20%) |  7/22 (32%)   0/1 (0%)     0/0          5/16 (31%) |
|FIRST INCIDENCE (DAYS) |   547          541          622          568       |   693          645          559          674       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.175N     P=0.155N     P=0.062N     P=0.157N   |  P=0.437      P=0.323N     P=0.577N     P=0.529    |
|INCIDENTAL TUMOR       |  P=0.209N     P=0.368N     P=0.042N*    P=0.322N   |  P=0.521      P=0.344N     P=0.375N     P=0.593    |
|LOGISTIC REGRESSION    |  P=0.203N     P=0.350N     P=0.042N*    P=0.255N   |  P=0.516      P=0.294N     P=0.377N     P=0.601    |
|COCHRAN-ARMITAGE       |  P=0.247N                                          |  P=0.522N                                          |
|FISHER EXACT           |               P=0.211N     P=0.018N*    P=0.288N   |               P=0.019N*    P=0.070N     P=0.398N   |
|=================================================================================================================================|
|                                                                                                                                 |
|Thyroid Gland: C-Cell                                                                                                            |
|     Carcinoma or Adenoma                                                                                                        |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  9/50 (18%)   3/33 (9%)    1/41 (2%)    7/50 (14%) | 10/50 (20%)   1/35 (3%)    2/33 (6%)    8/50 (16%) |
|ADJUSTED (b)           |  54.2%        10.1%         3.4%        45.2%      |  39.3%         4.2%         5.9%        40.6%      |
|TERMINAL (d)           |  2/7 (29%)    0/0          0/0          3/10 (30%) |  7/22 (32%)   0/1 (0%)     0/0          5/16 (31%) |
|FIRST INCIDENCE (DAYS) |   547          541          622          568       |   693          645          559          674       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.249N     P=0.155N     P=0.062N     P=0.220N   |  P=0.437      P=0.323N     P=0.577N     P=0.529    |
|INCIDENTAL TUMOR       |  P=0.291N     P=0.368N     P=0.042N*    P=0.412N   |  P=0.521      P=0.344N     P=0.375N     P=0.593    |
|LOGISTIC REGRESSION    |  P=0.304N     P=0.350N     P=0.042N*    P=0.351N   |  P=0.516      P=0.294N     P=0.377N     P=0.601    |
|COCHRAN-ARMITAGE       |  P=0.369N                                          |  P=0.522N                                          |
|FISHER EXACT           |               P=0.211N     P=0.018N*    P=0.393N   |               P=0.019N*    P=0.070N     P=0.398N   |
|=================================================================================================================================|
         DATE: 04/04/96                     EXPERIMENT: 05188 TEST: 05                                                 PAGE  14
                         STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- SODIUM XYLENESULFONATE

                                                 MALE TERMINAL SACRIFICE AT 105 WEEKS
                                                 FEMALE TERMINAL SACRIFICE AT 106 WEEKS

|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   0 MG/KG      60 MG/KG     120          240       |   0 MG/KG      60 MG/KG     120          240       |
|                       |                             MG/KG        MG/KG     |                             MG/KG        MG/KG     |
|=================================================================================================================================|
|                                                                                                                                 |
|Thyroid Gland: Follicular Cell                                                                                                   |
|     Adenoma                                                                                                                     |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  0/50 (0%)    0/33 (0%)    0/41 (0%)    0/50 (0%)  |  1/50 (2%)    2/35 (6%)    0/33 (0%)    1/50 (2%)  |
|ADJUSTED (b)           |   0.0%         0.0%         0.0%         0.0%      |   4.5%        10.8%         0.0%         2.7%      |
|TERMINAL (d)           |  0/7 (0%)     0/0          0/0          0/10 (0%)  |  1/22 (5%)    0/1 (0%)     0/0          0/16 (0%)  |
|FIRST INCIDENCE (DAYS) |   ---          ---          ---          ---       |   736 (T)      708          ---          572       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |    (e)          (e)          (e)          (e)      |  P=0.545N     P=0.206        (e)        P=0.722    |
|INCIDENTAL TUMOR       |    (e)          (e)          (e)          (e)      |  P=0.475N     P=0.176        (e)        P=0.718N   |
|LOGISTIC REGRESSION    |    (e)          (e)          (e)          (e)      |  P=0.499N     P=0.032 *      (e)        P=0.756    |
|COCHRAN-ARMITAGE       |    (e)                                             |  P=0.479N                                          |
|FISHER EXACT           |                 (e)          (e)          (e)      |               P=0.367      P=0.602N     P=0.753N   |
|=================================================================================================================================|
|                                                                                                                                 |
|Thyroid Gland: Follicular Cell                                                                                                   |
|     Carcinoma or Adenoma                                                                                                        |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  1/50 (2%)    0/33 (0%)    1/41 (2%)    1/50 (2%)  |  1/50 (2%)    2/35 (6%)    0/33 (0%)    2/50 (4%)  |
|ADJUSTED (b)           |   7.1%         0.0%         2.3%        10.0%      |   4.5%        10.8%         0.0%         6.9%      |
|TERMINAL (d)           |  0/7 (0%)     0/0          0/0          1/10 (10%) |  1/22 (5%)    0/1 (0%)     0/0          0/16 (0%)  |
|FIRST INCIDENCE (DAYS) |   708          ---          527          735 (T)   |   736 (T)      708          ---          572       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.629      P=0.473N     P=0.736      P=0.691N   |  P=0.420      P=0.206        (e)        P=0.430    |
|INCIDENTAL TUMOR       |  P=0.630N     P=0.619N     P=0.749      P=0.748N   |  P=0.496      P=0.176        (e)        P=0.541    |
|LOGISTIC REGRESSION    |  P=0.576      P=0.731N     P=0.727      P=0.720N   |  P=0.476      P=0.032 *      (e)        P=0.483    |
|COCHRAN-ARMITAGE       |  P=0.564                                           |  P=0.495                                           |
|FISHER EXACT           |               P=0.602N     P=0.701      P=0.753N   |               P=0.367      P=0.602N     P=0.500    |
|=================================================================================================================================|
         DATE: 04/04/96                     EXPERIMENT: 05188 TEST: 05                                                 PAGE  15
                         STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- SODIUM XYLENESULFONATE

                                                 MALE TERMINAL SACRIFICE AT 105 WEEKS
                                                 FEMALE TERMINAL SACRIFICE AT 106 WEEKS

|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   0 MG/KG      60 MG/KG     120          240       |   0 MG/KG      60 MG/KG     120          240       |
|                       |                             MG/KG        MG/KG     |                             MG/KG        MG/KG     |
|=================================================================================================================================|
|                                                                                                                                 |
|Uterus                                                                                                                           |
|     Polyp Stromal                                                                                                               |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |                                                    |  2/50 (4%)    1/50 (2%)    1/50 (2%)    3/50 (6%)  |
|ADJUSTED (b)           |                                                    |   6.5%         2.9%         2.2%        14.4%      |
|TERMINAL (d)           |                                                    |  1/22 (5%)    0/16 (0%)    0/17 (0%)    2/16 (13%) |
|FIRST INCIDENCE (DAYS) |                                                    |   408          550          492          391       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |                                                    |  P=0.286      P=0.553N     P=0.509N     P=0.401    |
|INCIDENTAL TUMOR       |                                                    |  P=0.286      P=0.429N     P=0.508N     P=0.394    |
|LOGISTIC REGRESSION    |                                                    |  P=0.340      P=0.451N     P=0.541N     P=0.524    |
|COCHRAN-ARMITAGE       |                                                    |  P=0.324                                           |
|FISHER EXACT           |                                                    |               P=0.500N     P=0.500N     P=0.500    |
|=================================================================================================================================|
|                                                                                                                                 |
|Uterus                                                                                                                           |
|     Sarcoma Stromal or Polyp Stromal                                                                                            |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |                                                    |  2/50 (4%)    2/50 (4%)    2/50 (4%)    3/50 (6%)  |
|ADJUSTED (b)           |                                                    |   6.5%         5.0%         6.6%        14.4%      |
|TERMINAL (d)           |                                                    |  1/22 (5%)    0/16 (0%)    0/17 (0%)    2/16 (13%) |
|FIRST INCIDENCE (DAYS) |                                                    |   408          446          492          391       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |                                                    |  P=0.339      P=0.650      P=0.670      P=0.401    |
|INCIDENTAL TUMOR       |                                                    |  P=0.346      P=0.632N     P=0.688      P=0.394    |
|LOGISTIC REGRESSION    |                                                    |  P=0.406      P=0.623N     P=0.687      P=0.524    |
|COCHRAN-ARMITAGE       |                                                    |  P=0.387                                           |
|FISHER EXACT           |                                                    |               P=0.691N     P=0.691N     P=0.500    |
|=================================================================================================================================|
         DATE: 04/04/96                     EXPERIMENT: 05188 TEST: 05                                                 PAGE  16
                         STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- SODIUM XYLENESULFONATE

                                                 MALE TERMINAL SACRIFICE AT 105 WEEKS
                                                 FEMALE TERMINAL SACRIFICE AT 106 WEEKS

|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   0 MG/KG      60 MG/KG     120          240       |   0 MG/KG      60 MG/KG     120          240       |
|                       |                             MG/KG        MG/KG     |                             MG/KG        MG/KG     |
|=================================================================================================================================|
|                                                                                                                                 |
|Zymbal's Gland                                                                                                                   |
|     Carcinoma                                                                                                                   |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #        |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  0/50 (0%)    0/46 (0%)    1/48 (2%)    2/50 (4%)  |  0/50 (0%)    0/50 (0%)    0/50 (0%)    1/50 (2%)  |
|ADJUSTED (b)           |   0.0%         0.0%         2.4%         8.8%      |   0.0%         0.0%         0.0%         2.1%      |
|TERMINAL (d)           |  0/7 (0%)     0/13 (0%)    0/7 (0%)     0/10 (0%)  |  0/22 (0%)    0/16 (0%)    0/17 (0%)    0/16 (0%)  |
|FIRST INCIDENCE (DAYS) |   ---          ---          538          525       |   ---          ---          ---          338       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.086        (e)        P=0.486      P=0.289    |  P=0.198        (e)          (e)        P=0.496    |
|INCIDENTAL TUMOR       |  P=0.102        (e)        P=0.500      P=0.252    |  P=0.301        (e)          (e)        P=0.718    |
|LOGISTIC REGRESSION    |  P=0.073        (e)        P=0.542      P=0.239    |  P=0.187        (e)          (e)        P=0.655    |
|COCHRAN-ARMITAGE       |  P=0.075                                           |  P=0.198                                           |
|FISHER EXACT           |                 (e)        P=0.490      P=0.247    |                 (e)          (e)        P=0.500    |
|=================================================================================================================================|
|                                                                                                                                 |
|Zymbal's Gland                                                                                                                   |
|     Carcinoma or Adenoma                                                                                                        |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #        |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  0/50 (0%)    0/46 (0%)    2/48 (4%)    2/50 (4%)  |  0/50 (0%)    0/50 (0%)    0/50 (0%)    1/50 (2%)  |
|ADJUSTED (b)           |   0.0%         0.0%         6.7%         8.8%      |   0.0%         0.0%         0.0%         2.1%      |
|TERMINAL (d)           |  0/7 (0%)     0/13 (0%)    0/7 (0%)     0/10 (0%)  |  0/22 (0%)    0/16 (0%)    0/17 (0%)    0/16 (0%)  |
|FIRST INCIDENCE (DAYS) |   ---          ---          538          525       |   ---          ---          ---          338       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.105        (e)        P=0.223      P=0.289    |  P=0.198        (e)          (e)        P=0.496    |
|INCIDENTAL TUMOR       |  P=0.114        (e)        P=0.228      P=0.252    |  P=0.301        (e)          (e)        P=0.718    |
|LOGISTIC REGRESSION    |  P=0.090        (e)        P=0.241      P=0.239    |  P=0.187        (e)          (e)        P=0.655    |
|COCHRAN-ARMITAGE       |  P=0.091                                           |  P=0.198                                           |
|FISHER EXACT           |                 (e)        P=0.237      P=0.247    |                 (e)          (e)        P=0.500    |
|=================================================================================================================================|
         DATE: 04/04/96                     EXPERIMENT: 05188 TEST: 05                                                 PAGE  17
                         STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- SODIUM XYLENESULFONATE

                                                 MALE TERMINAL SACRIFICE AT 105 WEEKS
                                                 FEMALE TERMINAL SACRIFICE AT 106 WEEKS

|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   0 MG/KG      60 MG/KG     120          240       |   0 MG/KG      60 MG/KG     120          240       |
|                       |                             MG/KG        MG/KG     |                             MG/KG        MG/KG     |
|=================================================================================================================================|
|                                                                                                                                 |
|All Organs                                                                                                                       |
|     Leukemia: Lymphocytic, Monocytic, Mononuclear, or Undifferentiated                                                          |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #        |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            | 12/50 (24%)  24/46 (52%)  15/48 (31%)  25/50 (50%) | 17/50 (34%)   5/50 (10%)   9/50 (18%)  10/50 (20%) |
|ADJUSTED (b)           |  50.5%       100.0%        91.2%       100.0%      |  53.3%        21.0%        28.9%        42.3%      |
|TERMINAL (d)           |  1/7 (14%)   13/13 (100%)  6/7 (86%)   10/10 (100%)|  8/22 (36%)   1/16 (6%)    0/17 (0%)    5/16 (31%) |
|FIRST INCIDENCE (DAYS) |   547          491          477          541       |   485          497          517          520       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.068      P=0.090      P=0.238      P=0.060    |  P=0.350N     P=0.036N*    P=0.183N     P=0.301N   |
|INCIDENTAL TUMOR       |  P=0.020 *    P=0.005 **   P=0.248      P=0.004 ** |  P=0.198N     P=0.013N*    P=0.040N*    P=0.143N   |
|LOGISTIC REGRESSION    |  P=0.022 *    P=0.002 **   P=0.238      P=0.005 ** |  P=0.212N     P=0.009N**   P=0.028N*    P=0.136N   |
|COCHRAN-ARMITAGE       |  P=0.031 *                                         |  P=0.179N                                          |
|FISHER EXACT           |               P=0.004 **   P=0.282      P=0.006 ** |               P=0.004N**   P=0.055N     P=0.088N   |
|=================================================================================================================================|
|                                                                                                                                 |
|All Organs                                                                                                                       |
|     Benign Tumors                                                                                                               |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #        |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            | 49/50 (98%)  29/46 (63%)  39/48 (81%)  49/50 (98%) | 40/50 (80%)  23/50 (46%)  26/50 (52%)  33/50 (66%) |
|ADJUSTED (b)           | 100.0%        69.9%        86.3%       100.0%      |  95.1%        59.4%        61.7%        86.1%      |
|TERMINAL (d)           |  7/7 (100%)   1/13 (8%)    1/7 (14%)   10/10 (100%)| 20/22 (91%)   2/16 (13%)   2/17 (12%)  11/16 (69%) |
|FIRST INCIDENCE (DAYS) |   441          349          439          428       |   408          446          441          391       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.386      P=0.008N**   P=0.284N     P=0.286N   |  P=0.433      P=0.113N     P=0.141N     P=0.484    |
|INCIDENTAL TUMOR       |  P=0.051      P<0.001N**   P=0.009N**   P=0.684    |  P=0.215N     P<0.001N**   P<0.001N**   P=0.126N   |
|LOGISTIC REGRESSION    |  P=0.074      P<0.001N**   P=0.007N**   P=0.633    |  P=0.272N     P<0.001N**   P<0.001N**   P=0.141N   |
|COCHRAN-ARMITAGE       |  P=0.101                                           |  P=0.295N                                          |
|FISHER EXACT           |               P<0.001N**   P=0.006N**   P=0.753N   |               P<0.001N**   P=0.003N**   P=0.088N   |
|=================================================================================================================================|
         DATE: 04/04/96                     EXPERIMENT: 05188 TEST: 05                                                 PAGE  18
                         STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- SODIUM XYLENESULFONATE

                                                 MALE TERMINAL SACRIFICE AT 105 WEEKS
                                                 FEMALE TERMINAL SACRIFICE AT 106 WEEKS

|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   0 MG/KG      60 MG/KG     120          240       |   0 MG/KG      60 MG/KG     120          240       |
|                       |                             MG/KG        MG/KG     |                             MG/KG        MG/KG     |
|=================================================================================================================================|
|                                                                                                                                 |
|All Organs                                                                                                                       |
|     Malignant Tumors                                                                                                            |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #        |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            | 20/50 (40%)  29/46 (63%)  25/48 (52%)  32/50 (64%) | 23/50 (46%)   8/50 (16%)  11/50 (22%)  15/50 (30%) |
|ADJUSTED (b)           |  63.8%       100.0%        93.6%       100.0%      |  61.2%        27.9%        33.1%        53.5%      |
|TERMINAL (d)           |  1/7 (14%)   13/13 (100%)  6/7 (86%)   10/10 (100%)|  9/22 (41%)   1/16 (6%)    0/17 (0%)    6/16 (38%) |
|FIRST INCIDENCE (DAYS) |   527          491          477          433       |   303          446          492          338       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.120      P=0.266      P=0.175      P=0.139    |  P=0.361N     P=0.025N*    P=0.070N     P=0.312N   |
|INCIDENTAL TUMOR       |  P=0.036 *    P=0.012 *    P=0.142      P=0.010 *  |  P=0.166N     P=0.002N**   P=0.009N**   P=0.082N   |
|LOGISTIC REGRESSION    |  P=0.028 *    P=0.012 *    P=0.154      P=0.012 *  |  P=0.179N     P=0.001N**   P=0.010N**   P=0.077N   |
|COCHRAN-ARMITAGE       |  P=0.033 *                                         |  P=0.177N                                          |
|FISHER EXACT           |               P=0.020 *    P=0.159      P=0.014 *  |               P=0.001N**   P=0.010N**   P=0.074N   |
|=================================================================================================================================|
|                                                                                                                                 |
|All Organs                                                                                                                       |
|     Malignant and Benign Tumors                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #        |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            | 50/50 (100%) 45/46 (98%)  46/48 (96%)  49/50 (98%) | 45/50 (90%)  25/50 (50%)  27/50 (54%)  41/50 (82%) |
|ADJUSTED (b)           | 100.0%       100.0%       100.0%       100.0%      |  95.7%        62.3%        63.1%        95.3%      |
|TERMINAL (d)           |  7/7 (100%)  13/13 (100%)  7/7 (100%)  10/10 (100%)| 20/22 (91%)   2/16 (13%)   2/17 (12%)  14/16 (88%) |
|FIRST INCIDENCE (DAYS) |   441          349          439          428       |   303          446          441          338       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.380N     P=0.144N     P=0.541N     P=0.252N   |  P=0.233      P=0.072N     P=0.068N     P=0.272    |
|INCIDENTAL TUMOR       |  P=0.240N       (e)        P=0.500N     P=0.571N   |  P=0.507N     P<0.001N**   P<0.001N**   P=0.249N   |
|LOGISTIC REGRESSION    |  P=0.221N       (e)        P=0.458N     P=0.571N   |  P=0.490      P<0.001N**   P<0.001N**   P=0.273N   |
|COCHRAN-ARMITAGE       |  P=0.374N                                          |  P=0.479                                           |
|FISHER EXACT           |               P=0.479N     P=0.237N     P=0.500N   |               P<0.001N**   P<0.001N**   P=0.194N   |
|=================================================================================================================================|
         DATE: 04/04/96                     EXPERIMENT: 05188 TEST: 05                                                 PAGE  19
                         STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- SODIUM XYLENESULFONATE

                                                 MALE TERMINAL SACRIFICE AT 105 WEEKS
                                                 FEMALE TERMINAL SACRIFICE AT 106 WEEKS
                                                                           

 (a)  Number of tumor-bearing animals / number of animals examined at site.
 (b)  Kaplan-Meier estimated lifetime tumor incidence after adjustment for 
      intercurrent mortality.
 (d)  Observed incidence at terminal kill.
 (f)  Beneath the control incidence are the P-values associated with the trend 
      test.  Beneath the dosed group incidence are the P-values corresponding to 
      pairwise comparisons between the controls and that dosed group.  The life
      table analysis regards tumors in animals dying  prior to terminal kill as
      being (directly or indirectly) the cause of death.  The incidental tumor 
      test regards these lesions as non-fatal.  Logistic regression is an alternative
      method for analyzing the incidence of non-fatal tumors.  The Cochran-Armitage
      and Fisher's exact tests compare directly the overall incidence rates.  
      For all tests, a negative trend is indicated by "N".
 (e)  Value of Statistic cannot be computed. 
 (I)  Interim sacrifice
 (T)  Terminal sacrifice
  #   Tumor rates based on number of animals necropsied.

  *   To the right of any statistical result, indicates significance at (P<=0.05).
  **  To the right of any statistical result, indicates significance at (P<=0.01).