TDMS Study 05188-05 Pathology Tables
NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL
SODIUM XYLENESULFONATE
NTP Experiment-Test: 05188-05 Report: PEIRPT09
Study Type: CHRONIC Date: 09/19/95
Route: SKIN APPLICATION Time: 21:28:07
CORE STUDY
Facility: Battelle Columbus Laboratory
Chemical CAS #: 1300-72-7
Lock Date: 07/13/93
Cage Range: All
Reasons For Removal: All
Removal Date Range: All
Treatment Groups: Include All
Page 1
NTP Experiment-Test: 05188-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC SODIUM XYLENESULFONATE Date: 09/19/95
Route: SKIN APPLICATION Time: 21:28:07
_____________________________________________________________________________________________________________________
| 7| 6| 7| 7| 7| 7| 5| 6| 7| 5| 7| 6| 6| 4| 7| 6| 4| 7| 7| 6| 4| 6| 4| 7| 7|
DAY ON TEST | 3| 7| 3| 3| 3| 3| 9| 9| 3| 7| 1| 5| 5| 9| 3| 2| 8| 3| 3| 4| 2| 0| 8| 3| 3|
| 6| 4| 6| 6| 6| 6| 1| 2| 6| 5| 8| 6| 7| 0| 6| 9| 5| 6| 6| 6| 0| 5| 8| 6| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
0 MG/KG | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | X |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | X X |
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ulcer | 3 |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | X X X X X X X X X X X X X X |
Clear Cell Focus | |
Hepatodiaphragmatic Nodule | X X X X X X |
Inflammation, Chronic | 1 2 2 1 1 1 2 1 2 1 |
Necrosis | 3 3 |
Pigmentation, Hemosiderin | 2 2 |
Pigmentation, Melanin | 2 |
Bile Duct, Hyperplasia | 3 2 1 2 2 1 1 1 1 2 1 2 1 1|
Central Vein, Thrombosis | 3 |
Hepatocyte, Hyperplasia | 3 |
Hepatocyte, Vacuolization Cytoplasmic| 1 2 2 4 1 1 1 2 1 1 |
Hepatocyte, Centrilobular, | |
Degeneration, Fatty | 4 4 |
__________________________________________________________________________|
Mesentery | + |
Mineralization | |
Fat, Inflammation, Chronic Active | 2 |
Fat, Necrosis | |
__________________________________________________________________________|
Oral Mucosa | |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Acinus, Atrophy | 1 1 1 2 3 1 1 1 1|
Artery, Inflammation, Chronic Active | 3 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | 3 |
Ulcer | 4 |
Epithelium, Hyperplasia | 3 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mineralization | 3 |
Necrosis | 4 |
Epithelium, Erosion | 3 |
Epithelium, Hemorrhage | 2 |
Epithelium, Necrosis | 4 |
__________________________________________________________________________|
Tooth | + |
_____________________________________________________________________________________________________________________|
Page 2
NTP Experiment-Test: 05188-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC SODIUM XYLENESULFONATE Date: 09/19/95
Route: SKIN APPLICATION Time: 21:28:07
_____________________________________________________________________________________________________________________
| 7| 6| 7| 7| 7| 7| 5| 6| 7| 5| 7| 6| 6| 4| 7| 6| 4| 7| 7| 6| 4| 6| 4| 7| 7|
DAY ON TEST | 3| 7| 3| 3| 3| 3| 9| 9| 3| 7| 1| 5| 5| 9| 3| 2| 8| 3| 3| 4| 2| 0| 8| 3| 3|
| 6| 4| 6| 6| 6| 6| 1| 2| 6| 5| 8| 6| 7| 0| 6| 9| 5| 6| 6| 6| 0| 5| 8| 6| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
0 MG/KG | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
Peridontal Tissue, Inflammation, | |
Chronic Active | 3 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mineralization | 3 |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy, Chronic | 2 3 2 3 2 1 1 2 |
Mineralization | 2 |
Atrium, Thrombosis | 4 4 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Accessory Adrenal Cortical Nodule | 3|
Atrophy | 2 |
Degeneration, Fatty | 1 2 2 1 1 3 3 2 3 1 |
Hyperplasia | 1 2 2 1 1 1 2 1 1 2 |
Hypertrophy | 1 |
Necrosis | |
Pigmentation, Hemosiderin | |
Pigmentation, Lipofuscin | 1 2 |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 3 1 1 1 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 |
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + M + + + + + + + + + + + +|
Hyperplasia | 3 |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 3 2 3 3 3 4 4 4 4 2 3 2 2 1 3 3 4 2 3 |
Mineralization | 2 |
Pigmentation, Hematoidin | 2 |
Pars Distalis, Atypia Cellular | |
Pars Distalis, Cyst | 2 2 2 2 3 3 |
Pars Distalis, Hyperplasia | 2 2 |
Pars Distalis, Pigmentation, | |
Hemosiderin | 2 1 1 1 2 3 1 1 1 2 2 2 2 2 1 1 2 2|
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ultimobranchial Cyst | |
C-Cell, Hyperplasia | 1 1 1|
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
_____________________________________________________________________________________________________________________|
Page 3
NTP Experiment-Test: 05188-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC SODIUM XYLENESULFONATE Date: 09/19/95
Route: SKIN APPLICATION Time: 21:28:07
_____________________________________________________________________________________________________________________
| 7| 6| 7| 7| 7| 7| 5| 6| 7| 5| 7| 6| 6| 4| 7| 6| 4| 7| 7| 6| 4| 6| 4| 7| 7|
DAY ON TEST | 3| 7| 3| 3| 3| 3| 9| 9| 3| 7| 1| 5| 5| 9| 3| 2| 8| 3| 3| 4| 2| 0| 8| 3| 3|
| 6| 4| 6| 6| 6| 6| 1| 2| 6| 5| 8| 6| 7| 0| 6| 9| 5| 6| 6| 6| 0| 5| 8| 6| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
0 MG/KG | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
__________________________________________________________________________|
Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + M + +|
Hyperplasia | 2 |
Inflammation, Chronic Active | 2 2 2 2 |
Duct, Cyst | |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | 4 |
__________________________________________________________________________|
Vagina | + |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 3 4 3 4 3 3 4 4 4 4|
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + +|
Mediastinal, Pigmentation, | |
Hemosiderin | 2 1 1 1 2 1 1 2 2 2 1 2 2 2 1 2 1 2 1 2 2 1 |
Pancreatic, Pigmentation, Hemosiderin| |
Renal, Pigmentation, Hemosiderin | 3 |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pigmentation, Hemosiderin | |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ectasia | 3 |
Inflammation, Suppurative | 3 |
Pigmentation, Hemosiderin | |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Accessory Spleen | |
Fibrosis | 2 |
Hematopoietic Cell Proliferation | 2 |
Pigmentation, Hemosiderin | 2 |
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | 2 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Cystic | 2 3 2 2 3 2 2 2 2 2 3 1 3 2 3 2 2 1 2 2 2 1 3 3|
Duct, Cyst | |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Epidermis, Skin, Site of Application,| |
Hyperplasia | 2 |
Epidermis, Skin, Site of Application,| |
Ulcer | 3 |
Sebaceous Gland, Skin, Site of | |
Application, Hyperplasia | 2 |
Skin, Site of Application, | |
_____________________________________________________________________________________________________________________|
Page 4
NTP Experiment-Test: 05188-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC SODIUM XYLENESULFONATE Date: 09/19/95
Route: SKIN APPLICATION Time: 21:28:07
_____________________________________________________________________________________________________________________
| 7| 6| 7| 7| 7| 7| 5| 6| 7| 5| 7| 6| 6| 4| 7| 6| 4| 7| 7| 6| 4| 6| 4| 7| 7|
DAY ON TEST | 3| 7| 3| 3| 3| 3| 9| 9| 3| 7| 1| 5| 5| 9| 3| 2| 8| 3| 3| 4| 2| 0| 8| 3| 3|
| 6| 4| 6| 6| 6| 6| 1| 2| 6| 5| 8| 6| 7| 0| 6| 9| 5| 6| 6| 6| 0| 5| 8| 6| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
0 MG/KG | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM - cont | |
| |
Inflammation, Chronic Active | 2 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrous Osteodystrophy | 4 |
Osteopetrosis | 3 |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage, Acute | |
Hydrocephalus | 3 3 2 |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion, Acute | 4 4 3 4 4 4 4 4 4 |
Inflammation, Chronic Active | 1 1 |
Inflammation, Suppurative | |
Mineralization | 2 |
Alveolus, Infiltration Cellular, | |
Histiocyte | 1 1 1 1 1 1 1 1 1 1 1 1 1 |
Interstitium, Inflammation, Chronic | |
Active | 1 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | 2 3 |
Nasolacrimal Duct, Inflammation, | |
Chronic Active | 2 |
Nasolacrimal Duct, Inflammation, | |
Suppurative | 2 1 2|
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + |
Cornea, Inflammation, Suppurative | |
Lens, Cataract | |
Retina, Degeneration | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mineralization | 1 1 1 1 |
Nephropathy, Chronic | 2 2 3 2 4 2 2 3 1 1 1 2 1 2 1 2 2 1 2 1 3 1|
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 5
NTP Experiment-Test: 05188-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC SODIUM XYLENESULFONATE Date: 09/19/95
Route: SKIN APPLICATION Time: 21:28:07
__________________________________________________________________________________________________________________________________
| 5| 3| 4| 7| 6| 7| 7| 7| 7| 3| 6| 7| 4| 7| 7| 4| 5| 7| 7| 7| 6| 4| 7| 7| 7| |
DAY ON TEST | 4| 9| 2| 3| 9| 3| 0| 3| 3| 0| 9| 3| 0| 3| 3| 8| 4| 3| 3| 3| 8| 9| 3| 1| 3| |
| 5| 3| 0| 6| 8| 6| 8| 6| 6| 3| 3| 6| 8| 6| 2| 0| 8| 6| 6| 6| 2| 0| 6| 9| 6| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| A |
0 MG/KG | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Parasite Metazoan | X | 2 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Parasite Metazoan | X X | 4 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Ulcer | | 1 3.0|
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Basophilic Focus | X X X X X X X X X X X X X X X X| 30 |
Clear Cell Focus | X | 1 |
Hepatodiaphragmatic Nodule | X X X X | 10 |
Inflammation, Chronic | 1 2 1 1 1 1 1 2 1 2 1 | 21 1.3|
Necrosis | 2 | 3 2.7|
Pigmentation, Hemosiderin | 2 | 3 2.0|
Pigmentation, Melanin | | 1 2.0|
Bile Duct, Hyperplasia | 1 1 1 2 1 1 1 1 1 1 2 1 2 2| 28 1.4|
Central Vein, Thrombosis | | 1 3.0|
Hepatocyte, Hyperplasia | 3 | 2 3.0|
Hepatocyte, Vacuolization Cytoplasmic| 1 2 2 1 2 | 15 1.6|
Hepatocyte, Centrilobular, | | |
Degeneration, Fatty | 4 4 | 4 4.0|
__________________________________________________________________________|____________|
Mesentery | + | 2 |
Mineralization | 3 | 1 3.0|
Fat, Inflammation, Chronic Active | | 1 2.0|
Fat, Necrosis | 4 | 1 4.0|
__________________________________________________________________________|____________|
Oral Mucosa | + | 1 |
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Acinus, Atrophy | 1 2 2 | 12 1.4|
Artery, Inflammation, Chronic Active | | 1 3.0|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Chronic Active | 3 | 2 3.0|
Ulcer | 4 | 2 4.0|
Epithelium, Hyperplasia | 3 | 2 3.0|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Mineralization | | 1 3.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 6
NTP Experiment-Test: 05188-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC SODIUM XYLENESULFONATE Date: 09/19/95
Route: SKIN APPLICATION Time: 21:28:07
__________________________________________________________________________________________________________________________________
| 5| 3| 4| 7| 6| 7| 7| 7| 7| 3| 6| 7| 4| 7| 7| 4| 5| 7| 7| 7| 6| 4| 7| 7| 7| |
DAY ON TEST | 4| 9| 2| 3| 9| 3| 0| 3| 3| 0| 9| 3| 0| 3| 3| 8| 4| 3| 3| 3| 8| 9| 3| 1| 3| |
| 5| 3| 0| 6| 8| 6| 8| 6| 6| 3| 3| 6| 8| 6| 2| 0| 8| 6| 6| 6| 2| 0| 6| 9| 6| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| A |
0 MG/KG | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
Necrosis | | 1 4.0|
Epithelium, Erosion | | 1 3.0|
Epithelium, Hemorrhage | | 1 2.0|
Epithelium, Necrosis | | 1 4.0|
__________________________________________________________________________|____________|
Tooth | | 1 |
Peridontal Tissue, Inflammation, | | |
Chronic Active | | 1 3.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Mineralization | | 1 3.0|
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cardiomyopathy, Chronic | 1 1 2 2 1 1 1 1 | 16 1.6|
Mineralization | | 1 2.0|
Atrium, Thrombosis | 4 3 | 4 3.8|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Accessory Adrenal Cortical Nodule | 2 | 2 2.5|
Atrophy | | 1 2.0|
Degeneration, Fatty | 1 1 2 2 1 1 1 1 2 1 1 2 1 2| 24 1.6|
Hyperplasia | 1 1 1 2 1 1 1 | 17 1.3|
Hypertrophy | | 1 1.0|
Necrosis | 3 | 1 3.0|
Pigmentation, Hemosiderin | 2 | 1 2.0|
Pigmentation, Lipofuscin | 2 | 3 1.7|
__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | 1 1 1 1 1| 9 1.2|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | | 1 2.0|
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + + M + + + + + + + + + + + + + + + + +| 48 |
Hyperplasia | | 1 3.0|
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Angiectasis | 4 2 2 1 3 4 2 2 2 4 3 2 1 3 2 4 4| 36 2.8|
Mineralization | | 1 2.0|
Pigmentation, Hematoidin | | 1 2.0|
Pars Distalis, Atypia Cellular | 2 | 1 2.0|
Pars Distalis, Cyst | 1 2 2 2 2 2 1 2 1 2 2 1 2 1 2 | 21 1.9|
Pars Distalis, Hyperplasia | 2 2 2 2 2 2 2 | 9 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 7
NTP Experiment-Test: 05188-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC SODIUM XYLENESULFONATE Date: 09/19/95
Route: SKIN APPLICATION Time: 21:28:07
__________________________________________________________________________________________________________________________________
| 5| 3| 4| 7| 6| 7| 7| 7| 7| 3| 6| 7| 4| 7| 7| 4| 5| 7| 7| 7| 6| 4| 7| 7| 7| |
DAY ON TEST | 4| 9| 2| 3| 9| 3| 0| 3| 3| 0| 9| 3| 0| 3| 3| 8| 4| 3| 3| 3| 8| 9| 3| 1| 3| |
| 5| 3| 0| 6| 8| 6| 8| 6| 6| 3| 3| 6| 8| 6| 2| 0| 8| 6| 6| 6| 2| 0| 6| 9| 6| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| A |
0 MG/KG | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
Pars Distalis, Pigmentation, | | |
Hemosiderin | 2 2 1 1 2 2 1 2 2 2 1 2 2 2| 32 1.7|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Ultimobranchial Cyst | 2 | 1 2.0|
C-Cell, Hyperplasia | 1 1 1 2 | 7 1.1|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Hyperplasia | 2 | 2 2.0|
Inflammation, Chronic Active | 1 1 | 6 1.7|
Duct, Cyst | 4 | 1 4.0|
__________________________________________________________________________|____________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cyst | 2 3 2 | 3 2.3|
__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cyst | 3 | 2 3.5|
__________________________________________________________________________|____________|
Vagina | | 1 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | 4 3 4 4 4 3 4 4 4| 19 3.7|
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + +| 45 |
Mediastinal, Pigmentation, | | |
Hemosiderin | 1 2 2 1 2 2 1 1 1 1 1 1 2 1 2 1 1 2 2 2 1 1| 44 1.5|
Pancreatic, Pigmentation, Hemosiderin| 2 | 1 2.0|
Renal, Pigmentation, Hemosiderin | | 1 3.0|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Pigmentation, Hemosiderin | 1 1 | 2 1.0|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + M + + + + + + + + + + + + + +| 49 |
Ectasia | | 1 3.0|
Inflammation, Suppurative | | 1 3.0|
Pigmentation, Hemosiderin | 2 | 1 2.0|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Accessory Spleen | X X | 2 |
Fibrosis | 3 3| 3 2.7|
Hematopoietic Cell Proliferation | 2 | 2 2.0|
Pigmentation, Hemosiderin | 3 3 3 | 4 2.8|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 8
NTP Experiment-Test: 05188-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC SODIUM XYLENESULFONATE Date: 09/19/95
Route: SKIN APPLICATION Time: 21:28:07
__________________________________________________________________________________________________________________________________
| 5| 3| 4| 7| 6| 7| 7| 7| 7| 3| 6| 7| 4| 7| 7| 4| 5| 7| 7| 7| 6| 4| 7| 7| 7| |
DAY ON TEST | 4| 9| 2| 3| 9| 3| 0| 3| 3| 0| 9| 3| 0| 3| 3| 8| 4| 3| 3| 3| 8| 9| 3| 1| 3| |
| 5| 3| 0| 6| 8| 6| 8| 6| 6| 3| 3| 6| 8| 6| 2| 0| 8| 6| 6| 6| 2| 0| 6| 9| 6| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| A |
0 MG/KG | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Thymus | + + + + + + + + + + + + + + + + + M + + + + + + +| 49 |
Cyst | | 1 2.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia, Cystic | 2 2 2 2 2 2 2 2 2 2 3 2 2 1 1 2 2 2| 42 2.1|
Duct, Cyst | 4 | 1 4.0|
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Epidermis, Skin, Site of Application,| | |
Hyperplasia | | 1 2.0|
Epidermis, Skin, Site of Application,| | |
Ulcer | | 1 3.0|
Sebaceous Gland, Skin, Site of | | |
Application, Hyperplasia | 1 | 2 1.5|
Skin, Site of Application, | | |
Inflammation, Chronic Active | | 1 2.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Fibrous Osteodystrophy | | 1 4.0|
Osteopetrosis | | 1 3.0|
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hemorrhage, Acute | 4| 1 4.0|
Hydrocephalus | 3 3 2 3 3| 8 2.8|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Congestion, Acute | 3 4 4 4 | 13 3.8|
Inflammation, Chronic Active | 1 | 3 1.0|
Inflammation, Suppurative | 4 | 1 4.0|
Mineralization | | 1 2.0|
Alveolus, Infiltration Cellular, | | |
Histiocyte | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1| 32 1.0|
Interstitium, Inflammation, Chronic | | |
Active | 2 2 1 2 1 2 1 1 | 9 1.4|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Chronic Active | 2 2| 4 2.3|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 9
NTP Experiment-Test: 05188-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC SODIUM XYLENESULFONATE Date: 09/19/95
Route: SKIN APPLICATION Time: 21:28:07
__________________________________________________________________________________________________________________________________
| 5| 3| 4| 7| 6| 7| 7| 7| 7| 3| 6| 7| 4| 7| 7| 4| 5| 7| 7| 7| 6| 4| 7| 7| 7| |
DAY ON TEST | 4| 9| 2| 3| 9| 3| 0| 3| 3| 0| 9| 3| 0| 3| 3| 8| 4| 3| 3| 3| 8| 9| 3| 1| 3| |
| 5| 3| 0| 6| 8| 6| 8| 6| 6| 3| 3| 6| 8| 6| 2| 0| 8| 6| 6| 6| 2| 0| 6| 9| 6| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| A |
0 MG/KG | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont | | |
| | |
Nasolacrimal Duct, Inflammation, | | |
Chronic Active | | 1 2.0|
Nasolacrimal Duct, Inflammation, | | |
Suppurative | 2 2 2 1 3 1 2 | 10 1.8|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | + + | 3 |
Cornea, Inflammation, Suppurative | 3 | 1 3.0|
Lens, Cataract | 3 | 1 3.0|
Retina, Degeneration | 3 | 1 3.0|
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Mineralization | 1 1 1 1 1 1 | 10 1.0|
Nephropathy, Chronic | 2 1 2 1 2 2 2 1 2 2 1 1 1 1 3 2 1 2 2 2 2 1| 44 1.8|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 10
NTP Experiment-Test: 05188-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC SODIUM XYLENESULFONATE Date: 09/19/95
Route: SKIN APPLICATION Time: 21:28:07
_____________________________________________________________________________________________________________________
| 5| 2| 7| 7| 5| 6| 6| 6| 7| 4| 5| 6| 7| 7| 7| 7| 4| 7| 7| 6| 7| 7| 4| 6| 6|
DAY ON TEST | 8| 7| 3| 3| 2| 4| 2| 6| 3| 4| 9| 4| 0| 3| 3| 3| 9| 3| 3| 2| 3| 3| 4| 4| 4|
| 5| 7| 6| 6| 8| 4| 6| 6| 5| 7| 0| 3| 8| 6| 6| 6| 7| 6| 6| 2| 6| 6| 6| 5| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
60 MG/KG | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + +|
Parasite Metazoan | |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + +|
Parasite Metazoan | X |
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | 2 |
Ulcer | 3 |
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + +|
Basophilic Focus | X X X X X X X |
Hepatodiaphragmatic Nodule | X X X |
Inflammation, Chronic | 2 1 1 1 2 1 2 |
Necrosis | 2 |
Pigmentation, Hemosiderin | 2 |
Bile Duct, Hyperplasia | 1 2 1 1 2 1 1 1 1|
Hepatocyte, Centrilobular, | |
Degeneration, Fatty | 3 |
__________________________________________________________________________|
Mesentery | + + + |
Artery, Inflammation, Chronic Active | 3 |
Fat, Inflammation, Chronic Active | 4 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | |
Acinus, Atrophy | 1 1 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | 3 2 2 |
Ulcer | 4 3 |
Epithelium, Hyperplasia | 3 3 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | 2 |
Necrosis | 3 |
Epithelium, Erosion | 3 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + +|
Cardiomyopathy, Chronic | 3 2 1 2 1 1|
Atrium, Thrombosis | 4 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 11
NTP Experiment-Test: 05188-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC SODIUM XYLENESULFONATE Date: 09/19/95
Route: SKIN APPLICATION Time: 21:28:07
_____________________________________________________________________________________________________________________
| 5| 2| 7| 7| 5| 6| 6| 6| 7| 4| 5| 6| 7| 7| 7| 7| 4| 7| 7| 6| 7| 7| 4| 6| 6|
DAY ON TEST | 8| 7| 3| 3| 2| 4| 2| 6| 3| 4| 9| 4| 0| 3| 3| 3| 9| 3| 3| 2| 3| 3| 4| 4| 4|
| 5| 7| 6| 6| 8| 4| 6| 6| 5| 7| 0| 3| 8| 6| 6| 6| 7| 6| 6| 2| 6| 6| 6| 5| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
60 MG/KG | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
Degeneration, Fatty | 1 3 2 1 1 2 1 1 1 1|
Hyperplasia | 1 3 1 1 2|
Pigmentation, Lipofuscin | 1 2 |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + +|
Hyperplasia | 1 1 2 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + M + M + M + + + + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + +|
Angiectasis | 2 2 1 2 2 3 4 2 3 4 4|
Pigmentation, Hematoidin | 2 |
Pars Distalis, Cyst | 2 2 2 2 3 |
Pars Distalis, Hyperplasia | 2 2 2 2 2 2 2 |
Pars Distalis, Pigmentation, | |
Hemosiderin | 1 2 1 2 2 3 1 2 2 2|
Pars Distalis, Thrombosis | |
Pars Intermedia, Cyst | 2 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + +|
C-Cell, Hyperplasia | 2 |
Follicle, Cyst | 2 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | |
Inflammation, Chronic Active | 3 1 1|
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + +|
Cyst | 4 |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Vagina | + |
Inflammation, Suppurative | 3 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + +|
Hyperplasia | 4 3 3 |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + +|
Mediastinal, Pigmentation, | |
Hemosiderin | 1 1 2 1 1 2 2 2 2 1 2 1 1 1 2|
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + +|
Pigmentation, Hemosiderin | 1 1 1 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + +|
Hematopoietic Cell Proliferation | 4 |
_____________________________________________________________________________________________________________________|
Page 12
NTP Experiment-Test: 05188-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC SODIUM XYLENESULFONATE Date: 09/19/95
Route: SKIN APPLICATION Time: 21:28:07
_____________________________________________________________________________________________________________________
| 5| 2| 7| 7| 5| 6| 6| 6| 7| 4| 5| 6| 7| 7| 7| 7| 4| 7| 7| 6| 7| 7| 4| 6| 6|
DAY ON TEST | 8| 7| 3| 3| 2| 4| 2| 6| 3| 4| 9| 4| 0| 3| 3| 3| 9| 3| 3| 2| 3| 3| 4| 4| 4|
| 5| 7| 6| 6| 8| 4| 6| 6| 5| 7| 0| 3| 8| 6| 6| 6| 7| 6| 6| 2| 6| 6| 6| 5| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
60 MG/KG | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Necrosis | 4 |
Pigmentation, Hemosiderin | 3 3 3 |
Capsule, Fibrosis | 3 |
Capsule, Inflammation, Chronic Active| 2 |
Lymphoid Follicle, Depletion Cellular| 3 |
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + + + +|
Cyst | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + +|
Hyperplasia, Cystic | 2 3 2 2 2 1 2 2 3 2 2 2 4|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + +|
Femur, Osteosclerosis | 3 |
Tibia, Fracture | |
__________________________________________________________________________|
Skeletal Muscle | |
Inflammation, Chronic Active | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + +|
Hydrocephalus | 3 3 3|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + +|
Congestion, Acute | 4 4 4 4 4 4 |
Inflammation, Chronic Active | 1 |
Alveolar Epithelium, Hyperplasia | 1 |
Alveolus, Infiltration Cellular, | |
Histiocyte | 2 1 1 1 1 1 1 1 1 1 2 1 1 1|
Interstitium, Inflammation, Chronic | |
Active | 2 1 1|
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + +|
Nasolacrimal Duct, Inflammation, | |
Suppurative | 2|
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + |
Lens, Cataract | 4 |
Retina, Degeneration | 4 |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
_____________________________________________________________________________________________________________________|
Page 13
NTP Experiment-Test: 05188-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC SODIUM XYLENESULFONATE Date: 09/19/95
Route: SKIN APPLICATION Time: 21:28:07
_____________________________________________________________________________________________________________________
| 5| 2| 7| 7| 5| 6| 6| 6| 7| 4| 5| 6| 7| 7| 7| 7| 4| 7| 7| 6| 7| 7| 4| 6| 6|
DAY ON TEST | 8| 7| 3| 3| 2| 4| 2| 6| 3| 4| 9| 4| 0| 3| 3| 3| 9| 3| 3| 2| 3| 3| 4| 4| 4|
| 5| 7| 6| 6| 8| 4| 6| 6| 5| 7| 0| 3| 8| 6| 6| 6| 7| 6| 6| 2| 6| 6| 6| 5| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
60 MG/KG | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM - cont | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + +|
Infarct | 3 |
Mineralization | 1 1 1 1 1 1 1 1 1 1 1 |
Nephropathy, Chronic | 1 2 1 1 1 2 2 2 1 2 2 2|
Pelvis, Transitional Epithelium, | |
Hyperplasia | 4 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 14
NTP Experiment-Test: 05188-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC SODIUM XYLENESULFONATE Date: 09/19/95
Route: SKIN APPLICATION Time: 21:28:07
__________________________________________________________________________________________________________________________________
| 3| 5| 7| 5| 7| 5| 7| 3| 5| 2| 5| 7| 3| 7| 7| 5| 5| 7| 7| 5| 5| 4| 6| 7| 6| |
DAY ON TEST | 6| 2| 3| 4| 3| 3| 0| 0| 4| 0| 8| 2| 8| 3| 3| 6| 2| 3| 3| 5| 5| 8| 3| 3| 9| |
| 7| 5| 6| 7| 6| 7| 1| 1| 1| 1| 2| 2| 6| 6| 6| 3| 8| 6| 6| 9| 0| 6| 0| 6| 4| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| A |
60 MG/KG | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + +| 35 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + +| 35 |
Parasite Metazoan | X | 1 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + +| 35 |
Parasite Metazoan | X X | 3 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + +| 35 |
Inflammation, Chronic Active | | 1 2.0|
Ulcer | | 1 3.0|
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + +| 35 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + +| 35 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + +| 35 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + +| 35 |
Basophilic Focus | X X X X X| 12 |
Hepatodiaphragmatic Nodule | X X X| 6 |
Inflammation, Chronic | 1 1 2 1 1 1 1 1 1 1 | 17 1.2|
Necrosis | | 1 2.0|
Pigmentation, Hemosiderin | | 1 2.0|
Bile Duct, Hyperplasia | 2 2 1 1 | 13 1.3|
Hepatocyte, Centrilobular, | | |
Degeneration, Fatty | | 1 3.0|
__________________________________________________________________________|____________|
Mesentery | + | 4 |
Artery, Inflammation, Chronic Active | | 1 3.0|
Fat, Inflammation, Chronic Active | 3 | 2 3.5|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + +| 35 |
Inflammation, Chronic Active | 1 | 1 1.0|
Acinus, Atrophy | 1 | 3 1.0|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + +| 35 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + +| 35 |
Inflammation, Chronic Active | 3 | 4 2.5|
Ulcer | | 2 3.5|
Epithelium, Hyperplasia | 2 3 | 4 2.8|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + +| 35 |
Inflammation, Chronic Active | | 1 2.0|
Necrosis | | 1 3.0|
Epithelium, Erosion | | 1 3.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood Vessel | + + + + + + + + + + + + + + + + + +| 35 |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + +| 35 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 15
NTP Experiment-Test: 05188-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC SODIUM XYLENESULFONATE Date: 09/19/95
Route: SKIN APPLICATION Time: 21:28:07
__________________________________________________________________________________________________________________________________
| 3| 5| 7| 5| 7| 5| 7| 3| 5| 2| 5| 7| 3| 7| 7| 5| 5| 7| 7| 5| 5| 4| 6| 7| 6| |
DAY ON TEST | 6| 2| 3| 4| 3| 3| 0| 0| 4| 0| 8| 2| 8| 3| 3| 6| 2| 3| 3| 5| 5| 8| 3| 3| 9| |
| 7| 5| 6| 7| 6| 7| 1| 1| 1| 1| 2| 2| 6| 6| 6| 3| 8| 6| 6| 9| 0| 6| 0| 6| 4| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| A |
60 MG/KG | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM - cont | | |
| | |
Cardiomyopathy, Chronic | 1 1 1 3| 10 1.6|
Atrium, Thrombosis | | 1 4.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + +| 35 |
Degeneration, Fatty | 2 1| 12 1.4|
Hyperplasia | 2 1 3 1 1| 10 1.6|
Pigmentation, Lipofuscin | | 2 1.5|
__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + +| 35 |
Hyperplasia | | 3 1.3|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + +| 35 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + +| 32 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + + +| 35 |
Angiectasis | 2 4 4 4 2 1 3 3 2 3| 21 2.7|
Pigmentation, Hematoidin | | 1 2.0|
Pars Distalis, Cyst | 2 1 2 2 2 4| 11 2.2|
Pars Distalis, Hyperplasia | 2 2 2 2 | 11 2.0|
Pars Distalis, Pigmentation, | | |
Hemosiderin | 2 2 2 3 1 1 1 2 1 2| 20 1.8|
Pars Distalis, Thrombosis | 4 | 1 4.0|
Pars Intermedia, Cyst | 4 | 2 3.0|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + +| 35 |
C-Cell, Hyperplasia | 1 3 2 3 | 5 2.2|
Follicle, Cyst | | 1 2.0|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | 1 2 | 2 1.5|
Inflammation, Chronic Active | 3 | 4 2.0|
__________________________________________________________________________|____________|
Ovary | + + + + + + + + + + + + + + + + + +| 35 |
Cyst | | 1 4.0|
__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + + + + + + + + +| 35 |
__________________________________________________________________________|____________|
Vagina | | 1 |
Inflammation, Suppurative | | 1 3.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 16
NTP Experiment-Test: 05188-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC SODIUM XYLENESULFONATE Date: 09/19/95
Route: SKIN APPLICATION Time: 21:28:07
__________________________________________________________________________________________________________________________________
| 3| 5| 7| 5| 7| 5| 7| 3| 5| 2| 5| 7| 3| 7| 7| 5| 5| 7| 7| 5| 5| 4| 6| 7| 6| |
DAY ON TEST | 6| 2| 3| 4| 3| 3| 0| 0| 4| 0| 8| 2| 8| 3| 3| 6| 2| 3| 3| 5| 5| 8| 3| 3| 9| |
| 7| 5| 6| 7| 6| 7| 1| 1| 1| 1| 2| 2| 6| 6| 6| 3| 8| 6| 6| 9| 0| 6| 0| 6| 4| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| A |
60 MG/KG | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + +| 35 |
Hyperplasia | 4 | 4 3.5|
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + + + + + + +| 32 |
Mediastinal, Pigmentation, | | |
Hemosiderin | 1 2 2 2 2 1 1 2 2 2 1 2 2 2 1 2| 31 1.6|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + +| 35 |
Pigmentation, Hemosiderin | 1 2| 5 1.2|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + +| 35 |
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + +| 35 |
Hematopoietic Cell Proliferation | 3 3 3 | 4 3.3|
Necrosis | | 1 4.0|
Pigmentation, Hemosiderin | 3 3 | 5 3.0|
Capsule, Fibrosis | | 1 3.0|
Capsule, Inflammation, Chronic Active| | 1 2.0|
Lymphoid Follicle, Depletion Cellular| | 1 3.0|
__________________________________________________________________________|____________|
Thymus | + + + + + + + + + + + + + + + + + +| 35 |
Cyst | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + + + + + + + + +| 35 |
Hyperplasia, Cystic | 2 3 2 2 2 2 2 2 2 3| 23 2.2|
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + +| 35 |
Femur, Osteosclerosis | | 1 3.0|
Tibia, Fracture | X | 1 |
__________________________________________________________________________|____________|
Skeletal Muscle | + | 1 |
Inflammation, Chronic Active | 3 | 1 3.0|
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + +| 35 |
Hydrocephalus | 2 3 | 5 2.8|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + +| 35 |
Congestion, Acute | 4 4 4 4 4 4 4 4 | 14 4.0|
Inflammation, Chronic Active | 1 | 2 1.0|
Alveolar Epithelium, Hyperplasia | | 1 1.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 17
NTP Experiment-Test: 05188-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC SODIUM XYLENESULFONATE Date: 09/19/95
Route: SKIN APPLICATION Time: 21:28:07
__________________________________________________________________________________________________________________________________
| 3| 5| 7| 5| 7| 5| 7| 3| 5| 2| 5| 7| 3| 7| 7| 5| 5| 7| 7| 5| 5| 4| 6| 7| 6| |
DAY ON TEST | 6| 2| 3| 4| 3| 3| 0| 0| 4| 0| 8| 2| 8| 3| 3| 6| 2| 3| 3| 5| 5| 8| 3| 3| 9| |
| 7| 5| 6| 7| 6| 7| 1| 1| 1| 1| 2| 2| 6| 6| 6| 3| 8| 6| 6| 9| 0| 6| 0| 6| 4| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| A |
60 MG/KG | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont | | |
| | |
Alveolus, Infiltration Cellular, | | |
Histiocyte | 1 1 1 1 1 2 1 1 1| 23 1.1|
Interstitium, Inflammation, Chronic | | |
Active | 1 | 4 1.3|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + +| 35 |
Nasolacrimal Duct, Inflammation, | | |
Suppurative | 2 2 | 3 2.0|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + +| 35 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | + | 2 |
Lens, Cataract | 3 | 2 3.5|
Retina, Degeneration | | 1 4.0|
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + +| 35 |
Infarct | | 1 3.0|
Mineralization | 1 1 1 1 1 1 1 1 1 1 1| 22 1.0|
Nephropathy, Chronic | 1 1 1 2 1 1 1 1 1 1 1 1 2| 25 1.4|
Pelvis, Transitional Epithelium, | | |
Hyperplasia | | 1 4.0|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + +| 35 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 18
NTP Experiment-Test: 05188-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC SODIUM XYLENESULFONATE Date: 09/19/95
Route: SKIN APPLICATION Time: 21:28:07
_____________________________________________________________________________________________________________________
| 4| 6| 7| 7| 7| 5| 5| 7| 6| 6| 5| 5| 7| 7| 7| 6| 5| 7| 7| 5| 6| 7| 5| 7| 7|
DAY ON TEST | 4| 6| 0| 1| 3| 2| 4| 3| 2| 4| 1| 6| 3| 3| 3| 4| 9| 0| 3| 3| 7| 3| 6| 3| 3|
| 5| 0| 6| 2| 6| 7| 7| 6| 5| 5| 7| 4| 6| 6| 6| 3| 4| 8| 6| 2| 3| 6| 8| 6| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
120 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
MG/KG | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + |
Parasite Metazoan | |
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + |
Inflammation, Chronic Active | |
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + |
Inflammation, Chronic Active | 4 |
Ulcer | 4 |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + |
Basophilic Focus | X X X X X |
Hepatodiaphragmatic Nodule | X X X X X X X |
Inflammation, Chronic | 1 1 1 3 3 1 1 1 1 |
Necrosis | 2 2 |
Bile Duct, Hyperplasia | 1 1 1 2 2 1 1 1 2 1 |
Hepatocyte, Hyperplasia | 4 |
Hepatocyte, Vacuolization Cytoplasmic| 3 2 |
Hepatocyte, Centrilobular, | |
Degeneration, Fatty | 4 3 |
__________________________________________________________________________|
Mesentery | + + + |
Mineralization | 2 |
Fat, Inflammation, Chronic Active | |
Fat, Necrosis | 4 4 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + |
Cyst | |
Inflammation, Chronic Active | 4 |
Acinus, Atrophy | 2 2 1 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + |
Inflammation, Chronic Active | 3 |
Ulcer | 4 |
Epithelium, Hyperplasia | 2 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + |
Inflammation, Chronic Active | 2 |
Mineralization | |
Ulcer | 3 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | + + + + + + + + + + + + + + + + |
Mineralization | |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + |
Cardiomyopathy, Chronic | 2 2 1 1 1 2 2 |
_____________________________________________________________________________________________________________________|
Page 19
NTP Experiment-Test: 05188-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC SODIUM XYLENESULFONATE Date: 09/19/95
Route: SKIN APPLICATION Time: 21:28:07
_____________________________________________________________________________________________________________________
| 4| 6| 7| 7| 7| 5| 5| 7| 6| 6| 5| 5| 7| 7| 7| 6| 5| 7| 7| 5| 6| 7| 5| 7| 7|
DAY ON TEST | 4| 6| 0| 1| 3| 2| 4| 3| 2| 4| 1| 6| 3| 3| 3| 4| 9| 0| 3| 3| 7| 3| 6| 3| 3|
| 5| 0| 6| 2| 6| 7| 7| 6| 5| 5| 7| 4| 6| 6| 6| 3| 4| 8| 6| 2| 3| 6| 8| 6| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
120 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
MG/KG | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM - cont | |
| |
Inflammation, Chronic Active | 2 |
Mineralization | |
Atrium, Thrombosis | 4 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + |
Accessory Adrenal Cortical Nodule | 2 |
Degeneration, Fatty | 1 3 2 |
Hyperplasia | 2 2 1 1 2 |
Hypertrophy | 3 |
Karyomegaly | |
Pigmentation, Lipofuscin | 2 2 |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + |
Hyperplasia | |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + + + + |
Hyperplasia | |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + |
Angiectasis | 4 2 2 2 3 3 3 2 3 2 2 2 |
Mineralization | |
Pars Distalis, Cyst | 1 3 1 2 2 3 3 |
Pars Distalis, Hyperplasia | 3 2 |
Pars Distalis, Pigmentation, | |
Hemosiderin | 2 2 2 2 2 1 2 2 2 2 2 2 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + |
C-Cell, Hyperplasia | 2 1 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 |
Inflammation, Chronic Active | 2 |
Duct, Cyst | 4 |
Duct, Hyperplasia | 2 |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + |
Cyst | |
Inflammation, Chronic Active | |
Interstitial Cell, Hyperplasia | |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + |
Cyst | 3 |
__________________________________________________________________________|
Vagina | + |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
_____________________________________________________________________________________________________________________|
Page 20
NTP Experiment-Test: 05188-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC SODIUM XYLENESULFONATE Date: 09/19/95
Route: SKIN APPLICATION Time: 21:28:07
_____________________________________________________________________________________________________________________
| 4| 6| 7| 7| 7| 5| 5| 7| 6| 6| 5| 5| 7| 7| 7| 6| 5| 7| 7| 5| 6| 7| 5| 7| 7|
DAY ON TEST | 4| 6| 0| 1| 3| 2| 4| 3| 2| 4| 1| 6| 3| 3| 3| 4| 9| 0| 3| 3| 7| 3| 6| 3| 3|
| 5| 0| 6| 2| 6| 7| 7| 6| 5| 5| 7| 4| 6| 6| 6| 3| 4| 8| 6| 2| 3| 6| 8| 6| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
120 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
MG/KG | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + |
Hyperplasia | 3 3 4 4 4 4 4 |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + |
Mediastinal, Pigmentation, | |
Hemosiderin | 2 2 2 1 1 2 2 1 2 2 2 1 1 1 1 |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + |
Pigmentation, Hemosiderin | 1 1 2 1 1 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + |
Hematopoietic Cell Proliferation | 2 |
Pigmentation, Hemosiderin | 3 3 2 3 3 |
__________________________________________________________________________|
Thymus | + + + M + + + + + + + + + + + + |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + |
Hyperplasia, Cystic | 2 2 2 2 2 2 1 2 2 1 2 2 2 2 1 |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperkeratosis | |
Hyperplasia, Basal Cell | 3 |
Inflammation, Chronic Active | 3|
Epidermis, Hyperplasia | 2|
Epidermis, Ulcer | 4|
Epidermis, Skin, Site of Application,| |
Hyperplasia | 1 |
Epidermis, Skin, Site of Application,| |
Ulcer | |
Sebaceous Gland, Skin, Site of | |
Application, Hyperplasia | |
Skin, Site of Application, | |
Inflammation, Chronic Active | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + |
Fibrous Osteodystrophy | |
Osteopetrosis | 3 |
Joint, Arthrosis | |
Joint, Tarsal, Arthrosis | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + |
Hydrocephalus | 3 3 |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
_____________________________________________________________________________________________________________________|
Page 21
NTP Experiment-Test: 05188-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC SODIUM XYLENESULFONATE Date: 09/19/95
Route: SKIN APPLICATION Time: 21:28:07
_____________________________________________________________________________________________________________________
| 4| 6| 7| 7| 7| 5| 5| 7| 6| 6| 5| 5| 7| 7| 7| 6| 5| 7| 7| 5| 6| 7| 5| 7| 7|
DAY ON TEST | 4| 6| 0| 1| 3| 2| 4| 3| 2| 4| 1| 6| 3| 3| 3| 4| 9| 0| 3| 3| 7| 3| 6| 3| 3|
| 5| 0| 6| 2| 6| 7| 7| 6| 5| 5| 7| 4| 6| 6| 6| 3| 4| 8| 6| 2| 3| 6| 8| 6| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
120 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
MG/KG | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + |
Congestion, Acute | 4 4 |
Foreign Body | |
Inflammation, Chronic Active | |
Mineralization | |
Pigmentation, Hemosiderin | 2 |
Alveolus, Hemorrhage, Acute | |
Alveolus, Infiltration Cellular, | |
Histiocyte | 1 1 1 1 2 1 1 1 1 1 |
Interstitium, Inflammation, Chronic | |
Active | 2 2 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + |
Inflammation, Chronic Active | 2 |
Nasolacrimal Duct, Inflammation, | |
Suppurative | 2 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + |
Lens, Cataract | 3 |
Retina, Degeneration | 3 |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + |
Mineralization | 1 |
Nephropathy, Chronic | 1 1 1 1 1 2 3 1 1 3 1 1 1 2 1 |
Renal Tubule, Pigmentation, | |
Hemosiderin | |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + |
_____________________________________________________________________________________________________________________|
Page 22
NTP Experiment-Test: 05188-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC SODIUM XYLENESULFONATE Date: 09/19/95
Route: SKIN APPLICATION Time: 21:28:07
__________________________________________________________________________________________________________________________________
| 4| 7| 7| 6| 6| 6| 6| 6| 4| 7| 6| 7| 7| 5| 7| 6| 5| 7| 4| 5| 7| 7| 7| 5| 4| |
DAY ON TEST | 4| 3| 3| 6| 4| 0| 0| 3| 4| 1| 9| 3| 3| 1| 3| 4| 4| 3| 6| 0| 1| 3| 3| 5| 9| |
| 4| 6| 6| 6| 8| 3| 2| 8| 1| 7| 7| 6| 6| 0| 6| 6| 2| 6| 2| 1| 2| 6| 6| 9| 2| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| A |
120 | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
MG/KG | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + +| 33 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + +| 33 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + +| 33 |
Parasite Metazoan | X | 1 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + +| 33 |
Inflammation, Chronic Active | 2 | 1 2.0|
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + +| 33 |
Inflammation, Chronic Active | | 1 4.0|
Ulcer | | 1 4.0|
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + +| 33 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + M + + + + + + + + + + + + + + +| 32 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + +| 33 |
Basophilic Focus | X X X X X X | 11 |
Hepatodiaphragmatic Nodule | X X X X| 11 |
Inflammation, Chronic | 1 2 1 1 1 1 1 1 3 1 | 19 1.4|
Necrosis | 2 | 3 2.0|
Bile Duct, Hyperplasia | 1 1 1 1 2 1 1 | 17 1.2|
Hepatocyte, Hyperplasia | | 1 4.0|
Hepatocyte, Vacuolization Cytoplasmic| 1 2 | 4 2.0|
Hepatocyte, Centrilobular, | | |
Degeneration, Fatty | 4 | 3 3.7|
__________________________________________________________________________|____________|
Mesentery | + | 4 |
Mineralization | 3 | 2 2.5|
Fat, Inflammation, Chronic Active | 3 | 1 3.0|
Fat, Necrosis | | 2 4.0|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + +| 33 |
Cyst | 2 | 1 2.0|
Inflammation, Chronic Active | | 1 4.0|
Acinus, Atrophy | 3 1 | 5 1.8|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + +| 33 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + +| 33 |
Inflammation, Chronic Active | 2 3 | 3 2.7|
Ulcer | 4 4 | 3 4.0|
Epithelium, Hyperplasia | 3 3 | 3 2.7|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + +| 33 |
Inflammation, Chronic Active | | 1 2.0|
Mineralization | 3 | 1 3.0|
Ulcer | | 1 3.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 23
NTP Experiment-Test: 05188-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC SODIUM XYLENESULFONATE Date: 09/19/95
Route: SKIN APPLICATION Time: 21:28:07
__________________________________________________________________________________________________________________________________
| 4| 7| 7| 6| 6| 6| 6| 6| 4| 7| 6| 7| 7| 5| 7| 6| 5| 7| 4| 5| 7| 7| 7| 5| 4| |
DAY ON TEST | 4| 3| 3| 6| 4| 0| 0| 3| 4| 1| 9| 3| 3| 1| 3| 4| 4| 3| 6| 0| 1| 3| 3| 5| 9| |
| 4| 6| 6| 6| 8| 3| 2| 8| 1| 7| 7| 6| 6| 0| 6| 6| 2| 6| 2| 1| 2| 6| 6| 9| 2| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| A |
120 | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
MG/KG | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM - cont | | |
| | |
| | |
__________________________________________________________________________|____________|
Blood Vessel | + + + + + + + + + + + + + + + + +| 33 |
Mineralization | 3 | 1 3.0|
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + +| 33 |
Cardiomyopathy, Chronic | 1 1 1 2 2 3 1 2 | 15 1.6|
Inflammation, Chronic Active | | 1 2.0|
Mineralization | 3 | 1 3.0|
Atrium, Thrombosis | 3 | 2 3.5|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + + + + + + + +| 33 |
Accessory Adrenal Cortical Nodule | | 1 2.0|
Degeneration, Fatty | 1 1 1 1 | 7 1.4|
Hyperplasia | 1 | 6 1.5|
Hypertrophy | | 1 3.0|
Karyomegaly | 1 | 1 1.0|
Pigmentation, Lipofuscin | 1 2 | 4 1.8|
__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + + + + + + + +| 33 |
Hyperplasia | 2 | 1 2.0|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + +| 33 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + M + + + + + + M + + + + + + +| 31 |
Hyperplasia | 4 | 1 4.0|
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + +| 33 |
Angiectasis | 4 3 2 2 4 3 4 | 19 2.7|
Mineralization | 2 | 1 2.0|
Pars Distalis, Cyst | 1 2 2 2 2 4 2 1 | 15 2.1|
Pars Distalis, Hyperplasia | 2 2 2 2 2 | 7 2.1|
Pars Distalis, Pigmentation, | | |
Hemosiderin | 1 1 1 1 2 2 1 1 | 20 1.7|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + +| 33 |
C-Cell, Hyperplasia | 2 3 1 | 5 1.8|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | | 1 2.0|
Inflammation, Chronic Active | 3 4 4| 4 3.3|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 24
NTP Experiment-Test: 05188-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC SODIUM XYLENESULFONATE Date: 09/19/95
Route: SKIN APPLICATION Time: 21:28:07
__________________________________________________________________________________________________________________________________
| 4| 7| 7| 6| 6| 6| 6| 6| 4| 7| 6| 7| 7| 5| 7| 6| 5| 7| 4| 5| 7| 7| 7| 5| 4| |
DAY ON TEST | 4| 3| 3| 6| 4| 0| 0| 3| 4| 1| 9| 3| 3| 1| 3| 4| 4| 3| 6| 0| 1| 3| 3| 5| 9| |
| 4| 6| 6| 6| 8| 3| 2| 8| 1| 7| 7| 6| 6| 0| 6| 6| 2| 6| 2| 1| 2| 6| 6| 9| 2| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| A |
120 | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
MG/KG | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont | | |
| | |
Duct, Cyst | 3 | 2 3.5|
Duct, Hyperplasia | 2 | 2 2.0|
__________________________________________________________________________|____________|
Ovary | + + + + + + + + + + + + + + + + +| 33 |
Cyst | 2 2| 2 2.0|
Inflammation, Chronic Active | 4 | 1 4.0|
Interstitial Cell, Hyperplasia | 3 3 | 2 3.0|
__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + + + + + + + +| 33 |
Cyst | | 1 3.0|
__________________________________________________________________________|____________|
Vagina | | 1 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + +| 33 |
Hyperplasia | 4 4 3 4 4| 12 3.8|
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + + + | 27 |
Mediastinal, Pigmentation, | | |
Hemosiderin | 1 1 2 1 2 2 1 2 2 1 1 2 | 27 1.5|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + +| 33 |
Pigmentation, Hemosiderin | 2 | 6 1.3|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + +| 33 |
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + +| 33 |
Hematopoietic Cell Proliferation | 3 4| 3 3.0|
Pigmentation, Hemosiderin | 3 3 3 3 | 9 2.9|
__________________________________________________________________________|____________|
Thymus | + + + M + + + + + + + + + + + + +| 31 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + + + + + + + +| 33 |
Hyperplasia, Cystic | 2 1 2 2 4 2 2 1 2 3 2 2| 27 1.9|
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperkeratosis | 3 | 1 3.0|
Hyperplasia, Basal Cell | | 1 3.0|
Inflammation, Chronic Active | | 1 3.0|
Epidermis, Hyperplasia | | 1 2.0|
Epidermis, Ulcer | | 1 4.0|
Epidermis, Skin, Site of Application,| | |
Hyperplasia | 2 3 1 | 4 1.8|
Epidermis, Skin, Site of Application,| | |
Ulcer | 3 3 | 2 3.0|
Sebaceous Gland, Skin, Site of | | |
Application, Hyperplasia | 2 3 | 2 2.5|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 25
NTP Experiment-Test: 05188-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC SODIUM XYLENESULFONATE Date: 09/19/95
Route: SKIN APPLICATION Time: 21:28:07
__________________________________________________________________________________________________________________________________
| 4| 7| 7| 6| 6| 6| 6| 6| 4| 7| 6| 7| 7| 5| 7| 6| 5| 7| 4| 5| 7| 7| 7| 5| 4| |
DAY ON TEST | 4| 3| 3| 6| 4| 0| 0| 3| 4| 1| 9| 3| 3| 1| 3| 4| 4| 3| 6| 0| 1| 3| 3| 5| 9| |
| 4| 6| 6| 6| 8| 3| 2| 8| 1| 7| 7| 6| 6| 0| 6| 6| 2| 6| 2| 1| 2| 6| 6| 9| 2| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| A |
120 | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
MG/KG | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM - cont | | |
| | |
Skin, Site of Application, | | |
Inflammation, Chronic Active | 3 3 | 2 3.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + +| 33 |
Fibrous Osteodystrophy | 3 | 1 3.0|
Osteopetrosis | | 1 3.0|
Joint, Arthrosis | 4 | 1 4.0|
Joint, Tarsal, Arthrosis | 3 | 1 3.0|
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + +| 33 |
Hydrocephalus | 3 | 3 3.0|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + +| 33 |
Congestion, Acute | 4 4 4 4 4 4 | 8 4.0|
Foreign Body | X | 1 |
Inflammation, Chronic Active | 1 3 | 2 2.0|
Mineralization | 3 | 1 3.0|
Pigmentation, Hemosiderin | | 1 2.0|
Alveolus, Hemorrhage, Acute | 3 | 1 3.0|
Alveolus, Infiltration Cellular, | | |
Histiocyte | 1 1 1 1 1 1 1 1 1 1| 20 1.1|
Interstitium, Inflammation, Chronic | | |
Active | | 2 2.0|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + +| 33 |
Inflammation, Chronic Active | 3 | 2 2.5|
Nasolacrimal Duct, Inflammation, | | |
Suppurative | | 1 2.0|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + +| 33 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | + | 2 |
Lens, Cataract | 4 | 2 3.5|
Retina, Degeneration | 4 | 2 3.5|
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + +| 33 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 26
NTP Experiment-Test: 05188-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC SODIUM XYLENESULFONATE Date: 09/19/95
Route: SKIN APPLICATION Time: 21:28:07
__________________________________________________________________________________________________________________________________
| 4| 7| 7| 6| 6| 6| 6| 6| 4| 7| 6| 7| 7| 5| 7| 6| 5| 7| 4| 5| 7| 7| 7| 5| 4| |
DAY ON TEST | 4| 3| 3| 6| 4| 0| 0| 3| 4| 1| 9| 3| 3| 1| 3| 4| 4| 3| 6| 0| 1| 3| 3| 5| 9| |
| 4| 6| 6| 6| 8| 3| 2| 8| 1| 7| 7| 6| 6| 0| 6| 6| 2| 6| 2| 1| 2| 6| 6| 9| 2| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| A |
120 | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
MG/KG | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
URINARY SYSTEM - cont | | |
| | |
Mineralization | 1 1 1 1 1 1| 7 1.0|
Nephropathy, Chronic | 2 1 2 1 2 2 4 1 2 2 1 1| 27 1.6|
Renal Tubule, Pigmentation, | | |
Hemosiderin | 4 | 1 4.0|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + +| 33 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 27
NTP Experiment-Test: 05188-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC SODIUM XYLENESULFONATE Date: 09/19/95
Route: SKIN APPLICATION Time: 21:28:07
_____________________________________________________________________________________________________________________
| 5| 5| 7| 7| 5| 7| 3| 7| 6| 7| 7| 2| 6| 6| 7| 3| 7| 7| 3| 7| 6| 4| 7| 5| 6|
DAY ON TEST | 9| 2| 0| 3| 2| 3| 3| 3| 7| 3| 1| 8| 9| 4| 3| 7| 3| 1| 2| 3| 4| 4| 3| 5| 9|
| 6| 6| 6| 6| 0| 6| 8| 6| 7| 6| 4| 9| 5| 6| 6| 9| 6| 1| 4| 6| 0| 1| 6| 6| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
240 | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
MG/KG | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | X X|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | X |
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | |
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | |
Basophilic Focus | X X X X X X X X X X X|
Clear Cell Focus | |
Hematopoietic Cell Proliferation | 2 |
Hepatodiaphragmatic Nodule | X |
Inflammation, Chronic | 1 1 2 2 1 1 1 2 1 |
Mixed Cell Focus | |
Necrosis | 1 2 |
Bile Duct, Hyperplasia | 1 1 2 1 1 1 1 1 1 1 3 1 1 1|
Hepatocyte, Hyperplasia | |
Hepatocyte, Vacuolization Cytoplasmic| 1 1 1 |
Hepatocyte, Centrilobular, | |
Degeneration, Fatty | 4 |
Portal Vein, Thrombosis | |
__________________________________________________________________________|
Mesentery | + + |
Mineralization | 1 |
Fat, Inflammation, Chronic Active | 3 |
__________________________________________________________________________|
Oral Mucosa | + |
Gingival, Inflammation, Chronic | |
Active | 3 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hypertrophy, Focal | 4 |
Acinus, Atrophy | 2 2 1 1 |
Artery, Inflammation, Chronic Active | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | 2 3 |
Ulcer | 4 4 |
Epithelium, Hyperplasia | 2 3 2 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Tooth | |
Inflammation | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
_____________________________________________________________________________________________________________________|
Page 28
NTP Experiment-Test: 05188-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC SODIUM XYLENESULFONATE Date: 09/19/95
Route: SKIN APPLICATION Time: 21:28:07
_____________________________________________________________________________________________________________________
| 5| 5| 7| 7| 5| 7| 3| 7| 6| 7| 7| 2| 6| 6| 7| 3| 7| 7| 3| 7| 6| 4| 7| 5| 6|
DAY ON TEST | 9| 2| 0| 3| 2| 3| 3| 3| 7| 3| 1| 8| 9| 4| 3| 7| 3| 1| 2| 3| 4| 4| 3| 5| 9|
| 6| 6| 6| 6| 0| 6| 8| 6| 7| 6| 4| 9| 5| 6| 6| 9| 6| 1| 4| 6| 0| 1| 6| 6| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
240 | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
MG/KG | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM - cont | |
| |
| |
__________________________________________________________________________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy, Chronic | 1 2 2 1 1 1 2 1 2|
Atrium, Thrombosis | 4 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Accessory Adrenal Cortical Nodule | |
Degeneration, Fatty | 1 1 1 2 1 3 2 1 |
Hyperplasia | 1 2 2 2 1 1 1 2 |
Hypertrophy | 2 |
Karyomegaly | 2 |
Pigmentation, Lipofuscin | 2 2 1 |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 1 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | |
__________________________________________________________________________|
Parathyroid Gland | + + + + M + + + + + + + + M + + + + M + + + + M +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 2 2 4 3 2 4 3 3 2 2 2 3 2|
Pigmentation, Hematoidin | |
Pars Distalis, Cyst | 3 3 2 1 3 2 2 3 2 4 2 2 2 1 2 |
Pars Distalis, Hyperplasia | 2 2 2 2 2 2 2 2 3 |
Pars Distalis, Pigmentation, | |
Hemosiderin | 1 2 1 2 1 1 2 2 2 2 2 2 2 1 2 |
Pars Intermedia, Cyst | |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
C-Cell, Hyperplasia | 1 1 1 1 1 |
Follicle, Cyst | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 2 2 2 2 |
Inflammation, Chronic Active | 3 1 |
Duct, Cyst | |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | 4 4|
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
_____________________________________________________________________________________________________________________|
Page 29
NTP Experiment-Test: 05188-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC SODIUM XYLENESULFONATE Date: 09/19/95
Route: SKIN APPLICATION Time: 21:28:07
_____________________________________________________________________________________________________________________
| 5| 5| 7| 7| 5| 7| 3| 7| 6| 7| 7| 2| 6| 6| 7| 3| 7| 7| 3| 7| 6| 4| 7| 5| 6|
DAY ON TEST | 9| 2| 0| 3| 2| 3| 3| 3| 7| 3| 1| 8| 9| 4| 3| 7| 3| 1| 2| 3| 4| 4| 3| 5| 9|
| 6| 6| 6| 6| 0| 6| 8| 6| 7| 6| 4| 9| 5| 6| 6| 9| 6| 1| 4| 6| 0| 1| 6| 6| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
240 | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
MG/KG | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 4 4 4 4 3 4 3 |
Inflammation, Granulomatous | 2 |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + +|
Lumbar, Hyperplasia, Lymphoid | |
Mediastinal, Hyperplasia, Plasma Cell| 3 |
Mediastinal, Pigmentation, | |
Hemosiderin | 2 2 2 2 2 2 2 1 1 1 1 1 2 2 2 1 1|
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pigmentation, Hemosiderin | 2 1 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hematopoietic Cell Proliferation | 4 |
Pigmentation, Hemosiderin | 2 2 2 2 |
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + + + + + + + + + + + M|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Cystic | 2 2 3 3 1 2 2 2 2 3 1 2 4 2 2 1 2 2 1 2|
Duct, Cyst | 4 |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Epidermis, Skin, Site of Application,| |
Exudate | 1 |
Epidermis, Skin, Site of Application,| |
Hyperplasia | 1 1 1 |
Epidermis, Skin, Site of Application,| |
Inflammation, Chronic Active | 1 |
Epidermis, Skin, Site of Application,| |
Ulcer | |
Sebaceous Gland, Skin, Site of | |
Application, Hyperplasia | |
Skin, Site of Application, | |
Inflammation, Chronic Active | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Femur, Osteosclerosis | 2 |
Femur, Tibia, Osteosclerosis | 2 |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage, Acute | |
Hydrocephalus | 3 3 3 |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
_____________________________________________________________________________________________________________________|
Page 30
NTP Experiment-Test: 05188-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC SODIUM XYLENESULFONATE Date: 09/19/95
Route: SKIN APPLICATION Time: 21:28:07
_____________________________________________________________________________________________________________________
| 5| 5| 7| 7| 5| 7| 3| 7| 6| 7| 7| 2| 6| 6| 7| 3| 7| 7| 3| 7| 6| 4| 7| 5| 6|
DAY ON TEST | 9| 2| 0| 3| 2| 3| 3| 3| 7| 3| 1| 8| 9| 4| 3| 7| 3| 1| 2| 3| 4| 4| 3| 5| 9|
| 6| 6| 6| 6| 0| 6| 8| 6| 7| 6| 4| 9| 5| 6| 6| 9| 6| 1| 4| 6| 0| 1| 6| 6| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
240 | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
MG/KG | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion, Acute | 4 4 4 4 4 4 4 4|
Inflammation, Chronic Active | 2 1 |
Inflammation, Granulomatous | 1 |
Alveolar Epithelium, Hyperplasia | |
Alveolus, Infiltration Cellular, | |
Histiocyte | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 |
Interstitium, Inflammation, Chronic | |
Active | 2 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | 2 1 2 2 1 |
Nasolacrimal Duct, Inflammation, | |
Suppurative | 3 1 1 3 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + + |
Lens, Cataract | 4 |
Retina, Degeneration | 3 4 |
Retina, Hemorrhage | |
__________________________________________________________________________|
Zymbal's Gland | + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mineralization | 1 1 1 1 1 1 1 |
Nephropathy, Chronic | 1 1 1 1 1 1 2 2 2 1 2 2 2 2 2 2 2 2|
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 31
NTP Experiment-Test: 05188-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC SODIUM XYLENESULFONATE Date: 09/19/95
Route: SKIN APPLICATION Time: 21:28:07
__________________________________________________________________________________________________________________________________
| 5| 7| 7| 4| 7| 7| 3| 5| 7| 6| 5| 7| 5| 6| 6| 7| 6| 3| 6| 7| 5| 6| 7| 6| 6| |
DAY ON TEST | 7| 3| 3| 1| 3| 3| 9| 9| 3| 1| 8| 3| 1| 5| 7| 3| 3| 9| 1| 2| 0| 3| 3| 3| 5| |
| 2| 6| 6| 2| 6| 6| 6| 1| 6| 1| 9| 6| 5| 1| 4| 6| 3| 1| 5| 8| 7| 0| 6| 4| 3| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| A |
240 | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L |
MG/KG | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Parasite Metazoan | X | 3 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Parasite Metazoan | X X | 3 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Chronic Active | 2 | 1 2.0|
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Angiectasis | 2 | 1 2.0|
Basophilic Focus | X X X X X X X X X X X X X X X | 26 |
Clear Cell Focus | X | 1 |
Hematopoietic Cell Proliferation | | 1 2.0|
Hepatodiaphragmatic Nodule | X X | 3 |
Inflammation, Chronic | 1 1 1 2 3 1 2 1 1 2 2 1 2 3 1 | 24 1.5|
Mixed Cell Focus | X | 1 |
Necrosis | 4 | 3 2.3|
Bile Duct, Hyperplasia | 2 1 1 1 2 2 2 | 21 1.3|
Hepatocyte, Hyperplasia | 4 | 1 4.0|
Hepatocyte, Vacuolization Cytoplasmic| 3 | 4 1.5|
Hepatocyte, Centrilobular, | | |
Degeneration, Fatty | 4 | 2 4.0|
Portal Vein, Thrombosis | 2 | 1 2.0|
__________________________________________________________________________|____________|
Mesentery | + +| 4 |
Mineralization | | 1 1.0|
Fat, Inflammation, Chronic Active | 3 | 2 3.0|
__________________________________________________________________________|____________|
Oral Mucosa | + | 2 |
Gingival, Inflammation, Chronic | | |
Active | 2 | 2 2.5|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hypertrophy, Focal | | 1 4.0|
Acinus, Atrophy | 2 1 1 1 | 8 1.4|
Artery, Inflammation, Chronic Active | 3 | 1 3.0|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Chronic Active | 2 3| 4 2.5|
Ulcer | 4 | 3 4.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 32
NTP Experiment-Test: 05188-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC SODIUM XYLENESULFONATE Date: 09/19/95
Route: SKIN APPLICATION Time: 21:28:07
__________________________________________________________________________________________________________________________________
| 5| 7| 7| 4| 7| 7| 3| 5| 7| 6| 5| 7| 5| 6| 6| 7| 6| 3| 6| 7| 5| 6| 7| 6| 6| |
DAY ON TEST | 7| 3| 3| 1| 3| 3| 9| 9| 3| 1| 8| 3| 1| 5| 7| 3| 3| 9| 1| 2| 0| 3| 3| 3| 5| |
| 2| 6| 6| 2| 6| 6| 6| 1| 6| 1| 9| 6| 5| 1| 4| 6| 3| 1| 5| 8| 7| 0| 6| 4| 3| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| A |
240 | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L |
MG/KG | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
Epithelium, Hyperplasia | 2 3| 5 2.4|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Tooth | + | 1 |
Inflammation | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cardiomyopathy, Chronic | 1 2 2 2 1 1 1 1 1 1 1 2 1 2 | 23 1.4|
Atrium, Thrombosis | 2 | 2 3.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Accessory Adrenal Cortical Nodule | 3 | 1 3.0|
Degeneration, Fatty | 3 2 3 1 2 2| 14 1.8|
Hyperplasia | 1 2 2 1 1 2 2 1 1| 17 1.5|
Hypertrophy | | 1 2.0|
Karyomegaly | | 1 2.0|
Pigmentation, Lipofuscin | 2 2 2 1| 7 1.7|
__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | 2 1 2| 5 1.6|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | 2 | 1 2.0|
__________________________________________________________________________|____________|
Parathyroid Gland | + + + M + + + + + + + + + + + + + + + + + + + + +| 45 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Angiectasis | 4 3 2 2 2 4 4 3 2 4 4 2 2 4 4 2 4 1| 31 2.8|
Pigmentation, Hematoidin | 2 | 1 2.0|
Pars Distalis, Cyst | 3 2 1 2 2 4 3 1 2 2 3 1 3 2 | 29 2.2|
Pars Distalis, Hyperplasia | 3 2 2 2 2 3 1 1 | 17 2.1|
Pars Distalis, Pigmentation, | | |
Hemosiderin | 2 2 1 2 2 2 1 1 1 2 2 1 2 2 1 2| 31 1.6|
Pars Intermedia, Cyst | 2 2 | 2 2.0|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
C-Cell, Hyperplasia | 2 2 1| 8 1.3|
Follicle, Cyst | 3 | 1 3.0|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 33
NTP Experiment-Test: 05188-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC SODIUM XYLENESULFONATE Date: 09/19/95
Route: SKIN APPLICATION Time: 21:28:07
__________________________________________________________________________________________________________________________________
| 5| 7| 7| 4| 7| 7| 3| 5| 7| 6| 5| 7| 5| 6| 6| 7| 6| 3| 6| 7| 5| 6| 7| 6| 6| |
DAY ON TEST | 7| 3| 3| 1| 3| 3| 9| 9| 3| 1| 8| 3| 1| 5| 7| 3| 3| 9| 1| 2| 0| 3| 3| 3| 5| |
| 2| 6| 6| 2| 6| 6| 6| 1| 6| 1| 9| 6| 5| 1| 4| 6| 3| 1| 5| 8| 7| 0| 6| 4| 3| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| A |
240 | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L |
MG/KG | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont | | |
| | |
| | |
__________________________________________________________________________|____________|
Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | 3 3 1 2 2 | 10 2.1|
Inflammation, Chronic Active | 2 1 2 1 2| 7 1.7|
Duct, Cyst | 3 3 | 2 3.0|
__________________________________________________________________________|____________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cyst | 1 3 | 4 3.0|
__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + M + + + + + + M + + + + + + + + + +| 48 |
Hyperplasia | 4 4 4| 10 3.8|
Inflammation, Granulomatous | | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + +| 43 |
Lumbar, Hyperplasia, Lymphoid | 3 | 1 3.0|
Mediastinal, Hyperplasia, Plasma Cell| | 1 3.0|
Mediastinal, Pigmentation, | | |
Hemosiderin | 2 2 2 2 2 1 2 1 2 1 1 2 1 1 3 2 1 2 2 1 2 2 1| 40 1.6|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Pigmentation, Hemosiderin | 1 2 | 4 1.5|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + M + + + + + + + + + + + + + M + + + + + + + +| 48 |
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hematopoietic Cell Proliferation | | 1 4.0|
Pigmentation, Hemosiderin | 3 3 3 3 3 3 3 | 11 2.6|
__________________________________________________________________________|____________|
Thymus | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia, Cystic | 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 4 2 1 2 2 2| 42 2.0|
Duct, Cyst | | 1 4.0|
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Epidermis, Skin, Site of Application,| | |
Exudate | 1 | 2 1.0|
Epidermis, Skin, Site of Application,| | |
Hyperplasia | 2 2 | 5 1.4|
Epidermis, Skin, Site of Application,| | |
Inflammation, Chronic Active | | 1 1.0|
Epidermis, Skin, Site of Application,| | |
Ulcer | 4 2 | 2 3.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 34
NTP Experiment-Test: 05188-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC SODIUM XYLENESULFONATE Date: 09/19/95
Route: SKIN APPLICATION Time: 21:28:07
__________________________________________________________________________________________________________________________________
| 5| 7| 7| 4| 7| 7| 3| 5| 7| 6| 5| 7| 5| 6| 6| 7| 6| 3| 6| 7| 5| 6| 7| 6| 6| |
DAY ON TEST | 7| 3| 3| 1| 3| 3| 9| 9| 3| 1| 8| 3| 1| 5| 7| 3| 3| 9| 1| 2| 0| 3| 3| 3| 5| |
| 2| 6| 6| 2| 6| 6| 6| 1| 6| 1| 9| 6| 5| 1| 4| 6| 3| 1| 5| 8| 7| 0| 6| 4| 3| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| A |
240 | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L |
MG/KG | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM - cont | | |
| | |
Sebaceous Gland, Skin, Site of | | |
Application, Hyperplasia | 2 2 | 2 2.0|
Skin, Site of Application, | | |
Inflammation, Chronic Active | 3 2 | 2 2.5|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + M + + + + + + M + + + + + + + + + +| 48 |
Femur, Osteosclerosis | | 1 2.0|
Femur, Tibia, Osteosclerosis | | 1 2.0|
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hemorrhage, Acute | 3| 1 3.0|
Hydrocephalus | 3 3 3 3 | 7 3.0|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Congestion, Acute | 4 4 3 3 3 4 4 4 | 16 3.8|
Inflammation, Chronic Active | 1 2 | 4 1.5|
Inflammation, Granulomatous | 1 | 2 1.0|
Alveolar Epithelium, Hyperplasia | 3 2 2 2 | 4 2.3|
Alveolus, Infiltration Cellular, | | |
Histiocyte | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 2 1 1 1 1 1| 39 1.0|
Interstitium, Inflammation, Chronic | | |
Active | 1 1 3 1 | 5 1.6|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Chronic Active | 2 | 6 1.7|
Nasolacrimal Duct, Inflammation, | | |
Suppurative | 2 3 | 6 2.2|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | + + +| 5 |
Lens, Cataract | 4 3 | 3 3.7|
Retina, Degeneration | 4 3 | 4 3.5|
Retina, Hemorrhage | 3| 1 3.0|
__________________________________________________________________________|____________|
Zymbal's Gland | | 1 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 35
NTP Experiment-Test: 05188-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC SODIUM XYLENESULFONATE Date: 09/19/95
Route: SKIN APPLICATION Time: 21:28:07
__________________________________________________________________________________________________________________________________
| 5| 7| 7| 4| 7| 7| 3| 5| 7| 6| 5| 7| 5| 6| 6| 7| 6| 3| 6| 7| 5| 6| 7| 6| 6| |
DAY ON TEST | 7| 3| 3| 1| 3| 3| 9| 9| 3| 1| 8| 3| 1| 5| 7| 3| 3| 9| 1| 2| 0| 3| 3| 3| 5| |
| 2| 6| 6| 2| 6| 6| 6| 1| 6| 1| 9| 6| 5| 1| 4| 6| 3| 1| 5| 8| 7| 0| 6| 4| 3| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| A |
240 | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L |
MG/KG | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
URINARY SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Mineralization | 1 1 1 1 | 11 1.0|
Nephropathy, Chronic | 2 2 1 2 2 2 1 2 2 2 2 2 1 1 2 2 1 1 2| 37 1.6|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 36
NTP Experiment-Test: 05188-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC SODIUM XYLENESULFONATE Date: 09/19/95
Route: SKIN APPLICATION Time: 21:28:07
_____________________________________________________________________________________________________________________
| 5| 5| 7| 6| 4| 5| 5| 4| 6| 4| 6| 7| 5| 7| 6| 6| 6| 7| 7| 6| 6| 7| 7| 5| 7|
DAY ON TEST | 8| 6| 3| 5| 4| 6| 5| 4| 5| 9| 8| 3| 4| 0| 3| 1| 8| 0| 3| 4| 4| 0| 1| 9| 2|
| 3| 5| 5| 8| 7| 7| 4| 1| 2| 2| 1| 5| 7| 2| 6| 6| 2| 1| 5| 5| 8| 7| 5| 5| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
0 MG/KG | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | X X |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | |
Ulcer | |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | 4 |
Necrosis | 4 |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | X X |
Clear Cell Focus | X X |
Degeneration, Cystic | 1 2 1 2 2 2 1 2 2 2|
Hematopoietic Cell Proliferation | 2 |
Hepatodiaphragmatic Nodule | |
Inflammation, Chronic | 1 1 1 1 1 1 1 1 2 |
Necrosis | 1 1 2 3 1 |
Bile Duct, Hyperplasia | 1 2 1 2 1 2 2 1 1 2 2 2 1 3 3 1 2 2 3 2 1 1|
Hepatocyte, Hyperplasia | |
Hepatocyte, Vacuolization Cytoplasmic| 2 1 3 2 1 3 2 2 3|
Hepatocyte, Centrilobular, | |
Degeneration, Fatty | 4 |
Hepatocyte, Centrilobular, Necrosis | 3 |
__________________________________________________________________________|
Mesentery | + + + + + + |
Mineralization | 2 2 |
Fat, Inflammation, Chronic Active | 3 3 |
__________________________________________________________________________|
Oral Mucosa | |
Gingival, Inflammation, Chronic | |
Active | |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Acinus, Atrophy | 1 2 2 2 2 1 1 1 1 4 2 2 |
Acinus, Hyperplasia | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | |
Inflammation, Chronic Active | 3 3 3 |
Mineralization | 3 |
Ulcer | 4 4 4 |
Epithelium, Hyperplasia | 3 3 2 2 2|
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | |
_____________________________________________________________________________________________________________________|
Page 37
NTP Experiment-Test: 05188-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC SODIUM XYLENESULFONATE Date: 09/19/95
Route: SKIN APPLICATION Time: 21:28:07
_____________________________________________________________________________________________________________________
| 5| 5| 7| 6| 4| 5| 5| 4| 6| 4| 6| 7| 5| 7| 6| 6| 6| 7| 7| 6| 6| 7| 7| 5| 7|
DAY ON TEST | 8| 6| 3| 5| 4| 6| 5| 4| 5| 9| 8| 3| 4| 0| 3| 1| 8| 0| 3| 4| 4| 0| 1| 9| 2|
| 3| 5| 5| 8| 7| 7| 4| 1| 2| 2| 1| 5| 7| 2| 6| 6| 2| 1| 5| 5| 8| 7| 5| 5| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
0 MG/KG | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
Mineralization | 3 3 3 3|
Ulcer | |
Epithelium, Erosion | |
__________________________________________________________________________|
Tooth | |
Inflammation, Chronic Active | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mineralization | 3 1 4 4 4|
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy, Chronic | 2 2 3 1 2 3 1 2 2 2 2 3 2 2 2 |
Inflammation, Chronic Active | |
Mineralization | 3 2 3 2 3|
Atrium, Thrombosis | 4 4 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Accessory Adrenal Cortical Nodule | |
Degeneration, Fatty | 2 2 2 1 3 3 1 1 2 2 2 1 2|
Hyperplasia | 1 1 2 2 1 1 2 1 1 1 1 2|
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 1 1 2 1 1 2 1 1 1 1 1 1 2 2 1 2 1|
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + + + + M + + + + + + + +|
Hyperplasia | 4 4 2 2 2 3 4 4|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 4 2 2 2 2 3 3 4 4 2 2 2 4 3 2 3 4 4|
Mineralization | 1 2 3|
Pigmentation, Hematoidin | |
Pars Distalis, Cyst | 1 1 2 2 3 |
Pars Distalis, Hyperplasia | 2 2 2 1 2 2 2 |
Pars Distalis, Pigmentation, | |
Hemosiderin | 2 2 1 1 1 2 1 2 2 2 1 2 1|
Pars Intermedia, Cyst | 1 2 |
Pars Nervosa, Cyst | 3 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
C-Cell, Hyperplasia | 1 1|
Follicle, Cyst | 2 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Peritoneum | + + + |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 38
NTP Experiment-Test: 05188-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC SODIUM XYLENESULFONATE Date: 09/19/95
Route: SKIN APPLICATION Time: 21:28:07
_____________________________________________________________________________________________________________________
| 5| 5| 7| 6| 4| 5| 5| 4| 6| 4| 6| 7| 5| 7| 6| 6| 6| 7| 7| 6| 6| 7| 7| 5| 7|
DAY ON TEST | 8| 6| 3| 5| 4| 6| 5| 4| 5| 9| 8| 3| 4| 0| 3| 1| 8| 0| 3| 4| 4| 0| 1| 9| 2|
| 3| 5| 5| 8| 7| 7| 4| 1| 2| 2| 1| 5| 7| 2| 6| 6| 2| 1| 5| 5| 8| 7| 5| 5| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
0 MG/KG | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
Atrophy | 4 3 3 3 3 4 2 4 4 4 4 4 4 4|
Mineralization | 3 |
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 |
Inflammation, Chronic Active | 2 1 2 1 2 1 2 2 2 1 1 2 2 2 2 2 4 2 3 2 2 2 2 2|
Duct, Cyst | |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | 3 1 2 4 2 2 3 3 3 2 1 1 1 3 3 3 4 2 2 2 2 3 2 2|
Mineralization | 2|
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 3 3 |
Inflammation, Chronic Active | 2 |
Mineralization | 2|
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Artery, Inflammation, Chronic | 1 2 2 2 |
Germinal Epithelium, Atrophy | 3 3 3 1 4 1 4 1 4 4|
Interstitial Cell, Hyperplasia | 2 1 1 1 1 1 1 1 1 1 1|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 4 4 4 4 4 4 4 3 4 4 4 |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + |
Mediastinal, Ectasia | 2 |
Mediastinal, Pigmentation, | |
Hemosiderin | 1 2 1 1 2 1 2 1 1 1 2 2 1 1 2 2 2 2 2 |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ectasia | 4 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrosis | 3 3 |
Hematopoietic Cell Proliferation | 3 3 3 2 3 3 |
Pigmentation, Hemosiderin | |
Lymphoid Follicle, Depletion Cellular| |
__________________________________________________________________________|
Thymus | + + + + + + + + M + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Cystic | 2 1 2 3 1 1 2 4 3 2 2 2 2 2 2 2 2 2 2 3 2 4|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Sebaceous Gland, Skin, Site of | |
Application, Hyperplasia | 2 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 39
NTP Experiment-Test: 05188-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC SODIUM XYLENESULFONATE Date: 09/19/95
Route: SKIN APPLICATION Time: 21:28:07
_____________________________________________________________________________________________________________________
| 5| 5| 7| 6| 4| 5| 5| 4| 6| 4| 6| 7| 5| 7| 6| 6| 6| 7| 7| 6| 6| 7| 7| 5| 7|
DAY ON TEST | 8| 6| 3| 5| 4| 6| 5| 4| 5| 9| 8| 3| 4| 0| 3| 1| 8| 0| 3| 4| 4| 0| 1| 9| 2|
| 3| 5| 5| 8| 7| 7| 4| 1| 2| 2| 1| 5| 7| 2| 6| 6| 2| 1| 5| 5| 8| 7| 5| 5| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
0 MG/KG | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM - cont | |
| |
Fibrous Osteodystrophy | 3 3 4 4|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hydrocephalus | 3 3 4 3 2 2|
Mineralization | 2 |
Necrosis | 4 |
__________________________________________________________________________|
Peripheral Nerve | + |
__________________________________________________________________________|
Spinal Cord | + |
Axon, Degeneration | 1 |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion, Acute | 4 4 4 4 |
Inflammation, Chronic Active | 1 1 1 |
Inflammation, Granulomatous | |
Mineralization | 3 2 3|
Alveolar Epithelium, Hyperplasia | |
Alveolus, Hemorrhage, Acute | 3 |
Alveolus, Infiltration Cellular, | |
Histiocyte | 1 1 1 1 1 1 1 2 2 |
Interstitium, Inflammation, Chronic | |
Active | 2 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | 3 2 |
Polyp Inflammatory | 3 |
Nasolacrimal Duct, Inflammation, | |
Suppurative | 2 2 2 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + |
Anterior Chamber, Hemorrhage, Acute | |
Cornea, Inflammation, Suppurative | |
Lens, Cataract | 3 |
Retina, Degeneration | 4 |
__________________________________________________________________________|
Harderian Gland | |
Inflammation, Chronic | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mineralization | 1 1 |
Nephropathy, Chronic | 2 2 3 4 2 2 1 3 4 2 2 3 2 3 3 2 3 4 3 4 2 3 3 3 4|
Cortex, Cyst | 2 2 3|
_____________________________________________________________________________________________________________________|
Page 40
NTP Experiment-Test: 05188-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC SODIUM XYLENESULFONATE Date: 09/19/95
Route: SKIN APPLICATION Time: 21:28:07
_____________________________________________________________________________________________________________________
| 5| 5| 7| 6| 4| 5| 5| 4| 6| 4| 6| 7| 5| 7| 6| 6| 6| 7| 7| 6| 6| 7| 7| 5| 7|
DAY ON TEST | 8| 6| 3| 5| 4| 6| 5| 4| 5| 9| 8| 3| 4| 0| 3| 1| 8| 0| 3| 4| 4| 0| 1| 9| 2|
| 3| 5| 5| 8| 7| 7| 4| 1| 2| 2| 1| 5| 7| 2| 6| 6| 2| 1| 5| 5| 8| 7| 5| 5| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
0 MG/KG | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM - cont | |
| |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | |
Mineralization | |
_____________________________________________________________________________________________________________________|
Page 41
NTP Experiment-Test: 05188-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC SODIUM XYLENESULFONATE Date: 09/19/95
Route: SKIN APPLICATION Time: 21:28:07
__________________________________________________________________________________________________________________________________
| 7| 6| 7| 5| 7| 5| 7| 6| 4| 6| 6| 6| 5| 5| 5| 7| 7| 6| 5| 7| 6| 7| 6| 5| 7| |
DAY ON TEST | 1| 5| 3| 4| 0| 6| 2| 7| 9| 1| 1| 1| 2| 9| 8| 3| 2| 3| 3| 3| 8| 1| 8| 5| 3| |
| 2| 0| 5| 6| 8| 0| 4| 2| 9| 6| 8| 7| 7| 0| 2| 5| 8| 9| 4| 5| 7| 3| 7| 7| 5| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| A |
0 MG/KG | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Parasite Metazoan | X X | 4 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Chronic Active | 2 | 1 2.0|
Ulcer | 4 | 1 4.0|
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Chronic Active | | 1 4.0|
Necrosis | | 1 4.0|
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Basophilic Focus | X | 3 |
Clear Cell Focus | X | 3 |
Degeneration, Cystic | 2 1 | 12 1.7|
Hematopoietic Cell Proliferation | | 1 2.0|
Hepatodiaphragmatic Nodule | X X X X X X | 6 |
Inflammation, Chronic | 2 1 2 2 2 1 1 1 1 1 1 | 20 1.3|
Necrosis | 2 3 2 | 8 1.9|
Bile Duct, Hyperplasia | 2 2 2 3 1 1 1 3 1 1 2 2 2 1 1 2 1 3 1 1 2| 43 1.7|
Hepatocyte, Hyperplasia | 3 | 1 3.0|
Hepatocyte, Vacuolization Cytoplasmic| 3 3 3 2 3 1 1 1 4 2 1 2| 21 2.1|
Hepatocyte, Centrilobular, | | |
Degeneration, Fatty | 4 | 2 4.0|
Hepatocyte, Centrilobular, Necrosis | | 1 3.0|
__________________________________________________________________________|____________|
Mesentery | + + | 8 |
Mineralization | 1 | 3 1.7|
Fat, Inflammation, Chronic Active | 3 3 | 4 3.0|
__________________________________________________________________________|____________|
Oral Mucosa | + + | 2 |
Gingival, Inflammation, Chronic | | |
Active | 3 | 1 3.0|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Acinus, Atrophy | 1 2 1 1 1 1 1 1 1 1 1 1 2 | 25 1.4|
Acinus, Hyperplasia | 2 2 2| 3 2.0|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cyst | 4 | 1 4.0|
Inflammation, Chronic Active | 3 3 2 3 3 2 2 3 4 | 12 2.8|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 42
NTP Experiment-Test: 05188-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC SODIUM XYLENESULFONATE Date: 09/19/95
Route: SKIN APPLICATION Time: 21:28:07
__________________________________________________________________________________________________________________________________
| 7| 6| 7| 5| 7| 5| 7| 6| 4| 6| 6| 6| 5| 5| 5| 7| 7| 6| 5| 7| 6| 7| 6| 5| 7| |
DAY ON TEST | 1| 5| 3| 4| 0| 6| 2| 7| 9| 1| 1| 1| 2| 9| 8| 3| 2| 3| 3| 3| 8| 1| 8| 5| 3| |
| 2| 0| 5| 6| 8| 0| 4| 2| 9| 6| 8| 7| 7| 0| 2| 5| 8| 9| 4| 5| 7| 3| 7| 7| 5| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| A |
0 MG/KG | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
Mineralization | | 1 3.0|
Ulcer | 4 4 4 4 4 | 8 4.0|
Epithelium, Hyperplasia | 3 4 3 2 2 3 3 3 2 3 4 3 | 17 2.8|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Chronic Active | 2 2 2 | 3 2.0|
Mineralization | 3 2 3 2 2 | 9 2.7|
Ulcer | 4 4 | 2 4.0|
Epithelium, Erosion | 2 | 1 2.0|
__________________________________________________________________________|____________|
Tooth | + | 1 |
Inflammation, Chronic Active | 3 | 1 3.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Mineralization | 4 2 4 | 8 3.3|
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cardiomyopathy, Chronic | 3 2 2 2 2 3 2 2 2 2 2 1 2 2| 29 2.1|
Inflammation, Chronic Active | 1 | 1 1.0|
Mineralization | 2 3 | 7 2.6|
Atrium, Thrombosis | 4 4 | 4 4.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Accessory Adrenal Cortical Nodule | 2 | 1 2.0|
Degeneration, Fatty | 2 1 1 2 3 3 3 1 1 1 3 2 2 1 3 2 1 1 2 2 2| 34 1.9|
Hyperplasia | 2 2 2 2 2 2 1 1 1 1 2 2 3| 25 1.6|
__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | 1 1 2 2 1 1 1 1 2 1 2 1 2| 30 1.3|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + + + + + + + + + M + + M M + + + + + +| 46 |
Hyperplasia | 4 4 4 3 4 | 13 3.4|
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Angiectasis | 3 2 4 2 2 3 2 4 3 2 4 4 4 3 3 4 4 2 3 2| 38 2.9|
Mineralization | 2 1 | 5 1.8|
Pigmentation, Hematoidin | 2 2 | 2 2.0|
Pars Distalis, Cyst | 3 2 2 | 8 2.0|
Pars Distalis, Hyperplasia | 2 2 1 2 2 | 12 1.8|
Pars Distalis, Pigmentation, | | |
Hemosiderin | 2 2 2 1 2 2 1 1 2 2 1 2 2 2 1 1 3 3 2 2| 33 1.7|
Pars Intermedia, Cyst | | 2 1.5|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 43
NTP Experiment-Test: 05188-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC SODIUM XYLENESULFONATE Date: 09/19/95
Route: SKIN APPLICATION Time: 21:28:07
__________________________________________________________________________________________________________________________________
| 7| 6| 7| 5| 7| 5| 7| 6| 4| 6| 6| 6| 5| 5| 5| 7| 7| 6| 5| 7| 6| 7| 6| 5| 7| |
DAY ON TEST | 1| 5| 3| 4| 0| 6| 2| 7| 9| 1| 1| 1| 2| 9| 8| 3| 2| 3| 3| 3| 8| 1| 8| 5| 3| |
| 2| 0| 5| 6| 8| 0| 4| 2| 9| 6| 8| 7| 7| 0| 2| 5| 8| 9| 4| 5| 7| 3| 7| 7| 5| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| A |
0 MG/KG | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
Pars Nervosa, Cyst | | 1 3.0|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
C-Cell, Hyperplasia | 2 2 2 2 1 | 7 1.6|
Follicle, Cyst | 2 | 2 2.0|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Peritoneum | | 3 |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Atrophy | 4 4 4 4 4 2 2 4 3 4 4 | 25 3.6|
Mineralization | | 1 3.0|
__________________________________________________________________________|____________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | | 1 2.0|
Inflammation, Chronic Active | 1 2 2 2 2 2 2 2 2 2 1 2 1 2 2 2 1 2 1 2 2 2 2| 47 1.9|
Duct, Cyst | 3 | 1 3.0|
__________________________________________________________________________|____________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Chronic Active | 2 2 3 3 3 4 3 4 3 2 3 3 2 3 3 3 3 3 3 1 3 2 3 3 3| 49 2.6|
Mineralization | | 1 2.0|
__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Atrophy | 3 | 3 3.0|
Inflammation, Chronic Active | 4 | 2 3.0|
Mineralization | | 1 2.0|
__________________________________________________________________________|____________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Artery, Inflammation, Chronic | 2 2 3 2 1 2| 10 1.9|
Germinal Epithelium, Atrophy | 3 4 4 4 2 2 1 4 1 1 | 20 2.7|
Interstitial Cell, Hyperplasia | 1 2 1 1 1 1 1 1 1| 20 1.1|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | 4 3 4 4 4 4 4 4 4 2 4 4 3 3| 25 3.8|
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + + + + + + + + + +| 41 |
Mediastinal, Ectasia | | 1 2.0|
Mediastinal, Pigmentation, | | |
Hemosiderin | 1 1 3 1 1 1 2 1 1 2 2 2 1 1 1 1 1 2| 37 1.5|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Ectasia | | 1 4.0|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 44
NTP Experiment-Test: 05188-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC SODIUM XYLENESULFONATE Date: 09/19/95
Route: SKIN APPLICATION Time: 21:28:07
__________________________________________________________________________________________________________________________________
| 7| 6| 7| 5| 7| 5| 7| 6| 4| 6| 6| 6| 5| 5| 5| 7| 7| 6| 5| 7| 6| 7| 6| 5| 7| |
DAY ON TEST | 1| 5| 3| 4| 0| 6| 2| 7| 9| 1| 1| 1| 2| 9| 8| 3| 2| 3| 3| 3| 8| 1| 8| 5| 3| |
| 2| 0| 5| 6| 8| 0| 4| 2| 9| 6| 8| 7| 7| 0| 2| 5| 8| 9| 4| 5| 7| 3| 7| 7| 5| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| A |
0 MG/KG | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
Fibrosis | 3 2 3 2| 6 2.7|
Hematopoietic Cell Proliferation | 2 3 4 2 2 2 | 12 2.7|
Pigmentation, Hemosiderin | 3 2 2 2 | 4 2.3|
Lymphoid Follicle, Depletion Cellular| 3 | 1 3.0|
__________________________________________________________________________|____________|
Thymus | + + + + + + + M + + + + + + + + + + + + M M + + +| 46 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia, Cystic | 2 1 2 2 2 4 2 4 3 4 3 4 3 4 1 1 4 4 2 3| 42 2.5|
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Sebaceous Gland, Skin, Site of | | |
Application, Hyperplasia | | 1 2.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Fibrous Osteodystrophy | 3 4 2 4 3 2| 10 3.2|
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hydrocephalus | 2 3 2 2 3 | 11 2.6|
Mineralization | | 1 2.0|
Necrosis | | 1 4.0|
__________________________________________________________________________|____________|
Peripheral Nerve | | 1 |
__________________________________________________________________________|____________|
Spinal Cord | | 1 |
Axon, Degeneration | | 1 1.0|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Congestion, Acute | 4 3 3 4 4 4 | 10 3.8|
Inflammation, Chronic Active | | 3 1.0|
Inflammation, Granulomatous | 2 2 | 2 2.0|
Mineralization | 3 2 3 1 | 7 2.4|
Alveolar Epithelium, Hyperplasia | 3 3 3 | 3 3.0|
Alveolus, Hemorrhage, Acute | 3 2 | 3 2.7|
Alveolus, Infiltration Cellular, | | |
Histiocyte | 1 1 1 1 4 3 1 1 1 1 2 1 2 1 1| 24 1.4|
Interstitium, Inflammation, Chronic | | |
Active | 4 3 1 1 3 2 | 7 2.3|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 45
NTP Experiment-Test: 05188-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC SODIUM XYLENESULFONATE Date: 09/19/95
Route: SKIN APPLICATION Time: 21:28:07
__________________________________________________________________________________________________________________________________
| 7| 6| 7| 5| 7| 5| 7| 6| 4| 6| 6| 6| 5| 5| 5| 7| 7| 6| 5| 7| 6| 7| 6| 5| 7| |
DAY ON TEST | 1| 5| 3| 4| 0| 6| 2| 7| 9| 1| 1| 1| 2| 9| 8| 3| 2| 3| 3| 3| 8| 1| 8| 5| 3| |
| 2| 0| 5| 6| 8| 0| 4| 2| 9| 6| 8| 7| 7| 0| 2| 5| 8| 9| 4| 5| 7| 3| 7| 7| 5| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| A |
0 MG/KG | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont | | |
| | |
Inflammation, Chronic Active | 2 2 2 | 5 2.2|
Polyp Inflammatory | | 1 3.0|
Nasolacrimal Duct, Inflammation, | | |
Suppurative | 1 3 | 5 2.0|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | + + | 3 |
Anterior Chamber, Hemorrhage, Acute | 3 | 1 3.0|
Cornea, Inflammation, Suppurative | 2 | 1 2.0|
Lens, Cataract | 3 | 2 3.0|
Retina, Degeneration | 4 | 2 4.0|
__________________________________________________________________________|____________|
Harderian Gland | + | 1 |
Inflammation, Chronic | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Mineralization | 3 3 | 4 2.0|
Nephropathy, Chronic | 3 4 3 3 3 3 4 4 2 1 4 3 1 2 2 3 4 3 1 3 3 4 4 2 4| 50 2.8|
Cortex, Cyst | 3 3 3 2 2 | 8 2.5|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Chronic Active | 3 | 1 3.0|
Mineralization | 2 | 1 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 46
NTP Experiment-Test: 05188-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC SODIUM XYLENESULFONATE Date: 09/19/95
Route: SKIN APPLICATION Time: 21:28:07
_____________________________________________________________________________________________________________________
| 6| 7| 6| 5| 6| 4| 5| 7| 7| 7| 6| 7| 7| 7| 6| 5| 7| 7| 1| 5| 7| 4| 7| 7| 6|
DAY ON TEST | 0| 3| 4| 4| 3| 9| 4| 0| 3| 2| 1| 3| 3| 3| 4| 6| 3| 3| 9| 1| 3| 4| 3| 3| 5|
| 9| 5| 5| 7| 1| 1| 1| 2| 5| 6| 9| 5| 5| 5| 3| 5| 5| 5| 6| 6| 2| 1| 5| 5| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
60 MG/KG | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + +|
Parasite Metazoan | |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + +|
Parasite Metazoan | X X |
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | |
Ulcer | |
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | |
Ulcer | |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | |
Ulcer | |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | 3 |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + +|
Degeneration, Cystic | |
Hematopoietic Cell Proliferation | 2 |
Hepatodiaphragmatic Nodule | X |
Inflammation, Chronic | 1 1 1 1 1 |
Necrosis | 3 |
Pigmentation, Hemosiderin | 2 |
Bile Duct, Hyperplasia | 2 2 2 2 3 3 2 2 1 2 1 2 1 2|
Central Vein, Thrombosis | 2 |
Hepatocyte, Hyperplasia | |
Hepatocyte, Vacuolization Cytoplasmic| 4 1 3 1 1 3 |
Hepatocyte, Centrilobular, | |
Degeneration, Fatty | 4 |
Hepatocyte, Centrilobular, Necrosis | 2 3 4 |
__________________________________________________________________________|
Mesentery | + + + +|
Mineralization | 3|
Artery, Inflammation, Chronic Active | 3 |
Fat, Inflammation, Chronic Active | 4 3|
__________________________________________________________________________|
Oral Mucosa | |
Gingival, Inflammation, Chronic | |
Active | |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + +|
Acinus, Atrophy | 2 1 3 1 1 1 2 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | 3 2 3 2|
Ulcer | 3 3 4 2|
Epithelium, Hyperplasia | 3 2 3 2|
_____________________________________________________________________________________________________________________|
Page 47
NTP Experiment-Test: 05188-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC SODIUM XYLENESULFONATE Date: 09/19/95
Route: SKIN APPLICATION Time: 21:28:07
_____________________________________________________________________________________________________________________
| 6| 7| 6| 5| 6| 4| 5| 7| 7| 7| 6| 7| 7| 7| 6| 5| 7| 7| 1| 5| 7| 4| 7| 7| 6|
DAY ON TEST | 0| 3| 4| 4| 3| 9| 4| 0| 3| 2| 1| 3| 3| 3| 4| 6| 3| 3| 9| 1| 3| 4| 3| 3| 5|
| 9| 5| 5| 7| 1| 1| 1| 2| 5| 6| 9| 5| 5| 5| 3| 5| 5| 5| 6| 6| 2| 1| 5| 5| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
60 MG/KG | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | 3|
Mineralization | |
Necrosis | 2 |
Ulcer | 4|
Epithelium, Erosion | 3|
Epithelium, Hyperplasia | |
__________________________________________________________________________|
Tongue | + |
Cyst | 3 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + +|
Cardiomyopathy, Chronic | 2 2 2 2 2 2 2 2 1 3 2 |
Inflammation, Chronic Active | |
Mineralization | 2 |
Atrium, Thrombosis | 3 3 4 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + +|
Degeneration, Fatty | 3 2 3 1 1 2 2 2 2|
Hyperplasia | 1|
Hypertrophy | 2 |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + +|
Hyperplasia | 1 2 2|
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + +|
Hyperplasia | 2 |
__________________________________________________________________________|
Parathyroid Gland | + M + + + M + + + + + + + + + +|
Hyperplasia | |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + +|
Angiectasis | 2 4 3 2 2 3 4 3 4 4 2 2 |
Hemorrhage | |
Necrosis | |
Pigmentation, Hematoidin | 2 |
Pars Distalis, Cyst | 2 2 2 |
Pars Distalis, Hyperplasia | 2 2|
Pars Distalis, Pigmentation, | |
Hemosiderin | 1 2 1 2 3 1 2 1 1 1 2 |
Pars Distalis, Thrombosis | |
Pars Intermedia, Cyst | |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + +|
C-Cell, Hyperplasia | 1 2 2 2 2|
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
_____________________________________________________________________________________________________________________|
Page 48
NTP Experiment-Test: 05188-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC SODIUM XYLENESULFONATE Date: 09/19/95
Route: SKIN APPLICATION Time: 21:28:07
_____________________________________________________________________________________________________________________
| 6| 7| 6| 5| 6| 4| 5| 7| 7| 7| 6| 7| 7| 7| 6| 5| 7| 7| 1| 5| 7| 4| 7| 7| 6|
DAY ON TEST | 0| 3| 4| 4| 3| 9| 4| 0| 3| 2| 1| 3| 3| 3| 4| 6| 3| 3| 9| 1| 3| 4| 3| 3| 5|
| 9| 5| 5| 7| 1| 1| 1| 2| 5| 6| 9| 5| 5| 5| 3| 5| 5| 5| 6| 6| 2| 1| 5| 5| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
60 MG/KG | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM - cont | |
| |
__________________________________________________________________________|
Peritoneum | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + +|
Atrophy | 4 4 3 4 4|
Inflammation, Chronic Active | 3 |
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + +|
Hyperplasia | 4 |
Inflammation, Chronic Active | 2 2 2 2 2 2 2 2 1 2 1 3 2|
Duct, Cyst | |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | 2 2 2 2 2 1 4 3 3 3 3 2 2 3 3|
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + +|
Atrophy | 3 3 3 |
Inflammation, Chronic Active | |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + +|
Artery, Inflammation, Chronic | 1 |
Germinal Epithelium, Atrophy | 2 4 |
Interstitial Cell, Hyperplasia | 1 1 1 1 1 1 2|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | M + + + + + + + + + + + + + + +|
Hyperplasia | 4 4 4 4 4|
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + +|
Lumbar, Hyperplasia, Lymphoid | 4 |
Mediastinal, Infiltration Cellular, | |
Histiocyte | |
Mediastinal, Pigmentation, | |
Hemosiderin | 2 2 1 2 1 1 2 1 1 1 1 |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + +|
Ectasia | 2 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + +|
Hematopoietic Cell Proliferation | 3 3 2 3|
__________________________________________________________________________|
Thymus | + + + + M + + + + + M + + + + +|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + M + + + + + + + + + +|
Hyperplasia, Cystic | 2 1 2 2 3 2 2 3 2 2 2 4 1|
Duct, Cyst | |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperkeratosis | 3 |
Epidermis, Skin, Site of Application,| |
Hyperplasia | 1 |
_____________________________________________________________________________________________________________________|
Page 49
NTP Experiment-Test: 05188-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC SODIUM XYLENESULFONATE Date: 09/19/95
Route: SKIN APPLICATION Time: 21:28:07
_____________________________________________________________________________________________________________________
| 6| 7| 6| 5| 6| 4| 5| 7| 7| 7| 6| 7| 7| 7| 6| 5| 7| 7| 1| 5| 7| 4| 7| 7| 6|
DAY ON TEST | 0| 3| 4| 4| 3| 9| 4| 0| 3| 2| 1| 3| 3| 3| 4| 6| 3| 3| 9| 1| 3| 4| 3| 3| 5|
| 9| 5| 5| 7| 1| 1| 1| 2| 5| 6| 9| 5| 5| 5| 3| 5| 5| 5| 6| 6| 2| 1| 5| 5| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
60 MG/KG | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM - cont | |
| |
Sebaceous Gland, Skin, Site of | |
Application, Hyperplasia | |
Skin, Site of Application, | |
Inflammation, Chronic Active | 1 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | M + + + + + + + + + + + + + + +|
Fibrous Osteodystrophy | |
__________________________________________________________________________|
Skeletal Muscle | + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + +|
Hemorrhage, Acute | |
Hydrocephalus | 4 2 4 2 |
__________________________________________________________________________|
Peripheral Nerve | + |
__________________________________________________________________________|
Spinal Cord | + |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + +|
Congestion, Acute | 4 4 4 4 3 4 |
Inflammation, Chronic Active | |
Alveolar Epithelium, Hyperplasia | 1 2 |
Alveolus, Hemorrhage, Acute | |
Alveolus, Infiltration Cellular, | |
Histiocyte | 1 1 1 1 1 1 |
__________________________________________________________________________|
Nose | M + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | 2 2 3 |
Thrombosis | |
Nasolacrimal Duct, Inflammation, | |
Suppurative | 1 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + |
Lens, Cataract | |
Retina, Degeneration | 4 |
__________________________________________________________________________|
Harderian Gland | + |
Inflammation, Chronic | 2 |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + +|
Mineralization | 1 |
Nephropathy, Chronic | 3 3 2 2 2 3 3 2 3 2 1 2 3 3 2|
Cortex, Cyst | |
_____________________________________________________________________________________________________________________|
Page 50
NTP Experiment-Test: 05188-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC SODIUM XYLENESULFONATE Date: 09/19/95
Route: SKIN APPLICATION Time: 21:28:07
_____________________________________________________________________________________________________________________
| 6| 7| 6| 5| 6| 4| 5| 7| 7| 7| 6| 7| 7| 7| 6| 5| 7| 7| 1| 5| 7| 4| 7| 7| 6|
DAY ON TEST | 0| 3| 4| 4| 3| 9| 4| 0| 3| 2| 1| 3| 3| 3| 4| 6| 3| 3| 9| 1| 3| 4| 3| 3| 5|
| 9| 5| 5| 7| 1| 1| 1| 2| 5| 6| 9| 5| 5| 5| 3| 5| 5| 5| 6| 6| 2| 1| 5| 5| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
60 MG/KG | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM - cont | |
| |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 51
NTP Experiment-Test: 05188-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC SODIUM XYLENESULFONATE Date: 09/19/95
Route: SKIN APPLICATION Time: 21:28:07
__________________________________________________________________________________________________________________________________
| 7| 7| 6| 7| 7| 6| 7| 6| 6| 6| 3| 5| 6| 7| 7| 5| 7| 6| 7| 7| 3| 6| 6| 3| 7| |
DAY ON TEST | 3| 3| 3| 3| 1| 5| 3| 4| 0| 2| 6| 2| 0| 3| 0| 4| 3| 0| 3| 3| 9| 7| 0| 4| 0| |
| 5| 5| 1| 5| 0| 8| 5| 5| 3| 3| 2| 7| 9| 5| 2| 0| 5| 1| 5| 5| 3| 4| 3| 9| 2| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| A |
60 MG/KG | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + +| 33 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + +| 33 |
Parasite Metazoan | X | 1 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + +| 33 |
Parasite Metazoan | | 2 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + +| 33 |
Inflammation, Chronic Active | 3 | 1 3.0|
Ulcer | 4 | 1 4.0|
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + +| 33 |
Inflammation, Chronic Active | 2 | 1 2.0|
Ulcer | 4 | 1 4.0|
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + +| 33 |
Inflammation, Chronic Active | 4 | 1 4.0|
Ulcer | 4 | 1 4.0|
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + +| 33 |
Inflammation, Chronic Active | 3 | 2 3.0|
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + +| 45 |
Degeneration, Cystic | 4 3 1 2 | 4 2.5|
Hematopoietic Cell Proliferation | | 1 2.0|
Hepatodiaphragmatic Nodule | X | 2 |
Inflammation, Chronic | 1 1 1 1 | 9 1.0|
Necrosis | 3 2 2 | 4 2.5|
Pigmentation, Hemosiderin | | 1 2.0|
Bile Duct, Hyperplasia | 3 2 1 1 2 2 2 2 1 3 2 1 1 1 1| 29 1.8|
Central Vein, Thrombosis | | 1 2.0|
Hepatocyte, Hyperplasia | 4 | 1 4.0|
Hepatocyte, Vacuolization Cytoplasmic| 1 2 3 2 1| 11 2.0|
Hepatocyte, Centrilobular, | | |
Degeneration, Fatty | 4 4 4 | 4 4.0|
Hepatocyte, Centrilobular, Necrosis | | 3 3.0|
__________________________________________________________________________|____________|
Mesentery | + + + | 7 |
Mineralization | | 1 3.0|
Artery, Inflammation, Chronic Active | | 1 3.0|
Fat, Inflammation, Chronic Active | 2 | 3 3.0|
__________________________________________________________________________|____________|
Oral Mucosa | + | 1 |
Gingival, Inflammation, Chronic | | |
Active | 2 | 1 2.0|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + +| 33 |
Acinus, Atrophy | 2 1 1 3 1 3 | 13 1.7|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 52
NTP Experiment-Test: 05188-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC SODIUM XYLENESULFONATE Date: 09/19/95
Route: SKIN APPLICATION Time: 21:28:07
__________________________________________________________________________________________________________________________________
| 7| 7| 6| 7| 7| 6| 7| 6| 6| 6| 3| 5| 6| 7| 7| 5| 7| 6| 7| 7| 3| 6| 6| 3| 7| |
DAY ON TEST | 3| 3| 3| 3| 1| 5| 3| 4| 0| 2| 6| 2| 0| 3| 0| 4| 3| 0| 3| 3| 9| 7| 0| 4| 0| |
| 5| 5| 1| 5| 0| 8| 5| 5| 3| 3| 2| 7| 9| 5| 2| 0| 5| 1| 5| 5| 3| 4| 3| 9| 2| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| A |
60 MG/KG | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + +| 33 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + +| 33 |
Inflammation, Chronic Active | 3 3 2 3 3 3 3| 11 2.7|
Ulcer | 4 3 4 4 4 4| 10 3.5|
Epithelium, Hyperplasia | 4 2 3 3 4 3 3| 11 2.9|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + +| 33 |
Inflammation, Chronic Active | 2 3 3 | 4 2.8|
Mineralization | 2 | 1 2.0|
Necrosis | | 1 2.0|
Ulcer | 4 4 | 3 4.0|
Epithelium, Erosion | 4 2 4 | 4 3.3|
Epithelium, Hyperplasia | 2| 1 2.0|
__________________________________________________________________________|____________|
Tongue | | 1 |
Cyst | | 1 3.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood Vessel | + + + + + + + + + + + + + + + + +| 33 |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + +| 33 |
Cardiomyopathy, Chronic | 2 2 2 2 2 1 2 2 1 2| 21 1.9|
Inflammation, Chronic Active | 2 | 1 2.0|
Mineralization | | 1 2.0|
Atrium, Thrombosis | 4 4 4 | 6 3.7|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + + + + + + + +| 33 |
Degeneration, Fatty | 2 1 1 2 2 1 1 3 2 1 3 2 1 2| 23 1.8|
Hyperplasia | 2 1 1 3 2| 6 1.7|
Hypertrophy | 1 | 2 1.5|
__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + + + + + + + +| 33 |
Hyperplasia | 1 1 2 1 2 2 2| 10 1.6|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + +| 33 |
Hyperplasia | 2 | 2 2.0|
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + M + + + + + + + + + M| 29 |
Hyperplasia | 2 2 3 | 3 2.3|
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + +| 33 |
Angiectasis | 2 4 2 3 4 3 1 4 1 4 2 4 4 4| 26 3.0|
Hemorrhage | 4 | 1 4.0|
Necrosis | 2 | 1 2.0|
Pigmentation, Hematoidin | | 1 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 53
NTP Experiment-Test: 05188-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC SODIUM XYLENESULFONATE Date: 09/19/95
Route: SKIN APPLICATION Time: 21:28:07
__________________________________________________________________________________________________________________________________
| 7| 7| 6| 7| 7| 6| 7| 6| 6| 6| 3| 5| 6| 7| 7| 5| 7| 6| 7| 7| 3| 6| 6| 3| 7| |
DAY ON TEST | 3| 3| 3| 3| 1| 5| 3| 4| 0| 2| 6| 2| 0| 3| 0| 4| 3| 0| 3| 3| 9| 7| 0| 4| 0| |
| 5| 5| 1| 5| 0| 8| 5| 5| 3| 3| 2| 7| 9| 5| 2| 0| 5| 1| 5| 5| 3| 4| 3| 9| 2| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| A |
60 MG/KG | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
Pars Distalis, Cyst | 2 2 | 5 2.0|
Pars Distalis, Hyperplasia | 2 2 2 | 5 2.0|
Pars Distalis, Pigmentation, | | |
Hemosiderin | 1 1 1 2 1 2 2 1 2| 20 1.5|
Pars Distalis, Thrombosis | 4 | 1 4.0|
Pars Intermedia, Cyst | 2 2 | 2 2.0|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + +| 33 |
C-Cell, Hyperplasia | 1 1 2 | 8 1.6|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Peritoneum | + | 1 |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + + + + + + + +| 33 |
Atrophy | 4 4 4 4 2| 10 3.7|
Inflammation, Chronic Active | | 1 3.0|
__________________________________________________________________________|____________|
Preputial Gland | + + + + + + + + + + + + + + + + +| 33 |
Hyperplasia | | 1 4.0|
Inflammation, Chronic Active | 2 2 1 3 2 2 3 3 1 1 2 1 2 2| 27 1.9|
Duct, Cyst | 2 | 1 2.0|
__________________________________________________________________________|____________|
Prostate | + + + + + + + + + + + + + + + + +| 33 |
Inflammation, Chronic Active | 2 3 2 2 3 3 1 2 3 4 1 2 3 3 2 4 3| 32 2.5|
__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + + + + + + + + + + + + +| 33 |
Atrophy | 3 3 4 3| 7 3.1|
Inflammation, Chronic Active | 3 | 1 3.0|
__________________________________________________________________________|____________|
Testes | + + + + + + + + + + + + + + + + +| 33 |
Artery, Inflammation, Chronic | 2 | 2 1.5|
Germinal Epithelium, Atrophy | 4 4 4 2| 6 3.3|
Interstitial Cell, Hyperplasia | 1 1 1 1 1 1| 13 1.1|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + +| 32 |
Hyperplasia | 3 3 4 4 4 4 4 4 | 13 3.8|
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + + + +| 25 |
Lumbar, Hyperplasia, Lymphoid | | 1 4.0|
Mediastinal, Infiltration Cellular, | | |
Histiocyte | 4 | 1 4.0|
Mediastinal, Pigmentation, | | |
Hemosiderin | 1 1 1 1 1 2 1 1 2 3 2 1| 23 1.4|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 54
NTP Experiment-Test: 05188-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC SODIUM XYLENESULFONATE Date: 09/19/95
Route: SKIN APPLICATION Time: 21:28:07
__________________________________________________________________________________________________________________________________
| 7| 7| 6| 7| 7| 6| 7| 6| 6| 6| 3| 5| 6| 7| 7| 5| 7| 6| 7| 7| 3| 6| 6| 3| 7| |
DAY ON TEST | 3| 3| 3| 3| 1| 5| 3| 4| 0| 2| 6| 2| 0| 3| 0| 4| 3| 0| 3| 3| 9| 7| 0| 4| 0| |
| 5| 5| 1| 5| 0| 8| 5| 5| 3| 3| 2| 7| 9| 5| 2| 0| 5| 1| 5| 5| 3| 4| 3| 9| 2| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| A |
60 MG/KG | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + +| 33 |
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + +| 33 |
Ectasia | 4 2 | 3 2.7|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + +| 46 |
Hematopoietic Cell Proliferation | 2 3 | 6 2.7|
__________________________________________________________________________|____________|
Thymus | + + + + + + + + + + + + + + + + +| 31 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + + + + + + + +| 32 |
Hyperplasia, Cystic | 1 2 2 2 1 1 1 2 1 3 2 2 4| 26 2.0|
Duct, Cyst | 4| 1 4.0|
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperkeratosis | | 1 3.0|
Epidermis, Skin, Site of Application,| | |
Hyperplasia | | 1 1.0|
Sebaceous Gland, Skin, Site of | | |
Application, Hyperplasia | 1 | 1 1.0|
Skin, Site of Application, | | |
Inflammation, Chronic Active | | 1 1.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + +| 32 |
Fibrous Osteodystrophy | 3 | 1 3.0|
__________________________________________________________________________|____________|
Skeletal Muscle | + | 3 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + +| 33 |
Hemorrhage, Acute | 4 | 1 4.0|
Hydrocephalus | 3 3 3 3 2 3 3 3| 12 2.9|
__________________________________________________________________________|____________|
Peripheral Nerve | | 1 |
__________________________________________________________________________|____________|
Spinal Cord | | 1 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + +| 33 |
Congestion, Acute | 4 3 4 | 9 3.8|
Inflammation, Chronic Active | 1 | 1 1.0|
Alveolar Epithelium, Hyperplasia | | 2 1.5|
Alveolus, Hemorrhage, Acute | 2 | 1 2.0|
Alveolus, Infiltration Cellular, | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 55
NTP Experiment-Test: 05188-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC SODIUM XYLENESULFONATE Date: 09/19/95
Route: SKIN APPLICATION Time: 21:28:07
__________________________________________________________________________________________________________________________________
| 7| 7| 6| 7| 7| 6| 7| 6| 6| 6| 3| 5| 6| 7| 7| 5| 7| 6| 7| 7| 3| 6| 6| 3| 7| |
DAY ON TEST | 3| 3| 3| 3| 1| 5| 3| 4| 0| 2| 6| 2| 0| 3| 0| 4| 3| 0| 3| 3| 9| 7| 0| 4| 0| |
| 5| 5| 1| 5| 0| 8| 5| 5| 3| 3| 2| 7| 9| 5| 2| 0| 5| 1| 5| 5| 3| 4| 3| 9| 2| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| A |
60 MG/KG | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont | | |
| | |
Histiocyte | 1 1 1 1 | 10 1.0|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + +| 32 |
Inflammation, Chronic Active | 2 1 2 3 3 | 8 2.3|
Thrombosis | 2 | 1 2.0|
Nasolacrimal Duct, Inflammation, | | |
Suppurative | 3 1 | 3 1.7|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + +| 33 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | + | 2 |
Lens, Cataract | 3 | 1 3.0|
Retina, Degeneration | 4 | 2 4.0|
__________________________________________________________________________|____________|
Harderian Gland | | 1 |
Inflammation, Chronic | | 1 2.0|
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + +| 33 |
Mineralization | 1 1 | 3 1.0|
Nephropathy, Chronic | 2 2 3 3 2 2 2 1 4 4 2 3 2 2 2 2 3| 32 2.4|
Cortex, Cyst | 2 | 1 2.0|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + +| 33 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 56
NTP Experiment-Test: 05188-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC SODIUM XYLENESULFONATE Date: 09/19/95
Route: SKIN APPLICATION Time: 21:28:07
_____________________________________________________________________________________________________________________
| 7| 5| 7| 6| 5| 7| 7| 6| 6| 5| 7| 7| 4| 7| 6| 7| 6| 6| 5| 7| 5| 6| 6| 6| 7|
DAY ON TEST | 0| 3| 3| 2| 7| 1| 3| 5| 0| 7| 0| 3| 3| 3| 5| 3| 2| 6| 9| 3| 7| 5| 4| 2| 0|
| 0| 8| 5| 2| 1| 8| 5| 2| 6| 3| 8| 5| 9| 5| 0| 5| 2| 6| 4| 5| 9| 3| 6| 1| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
120 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
MG/KG | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | X |
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | 2 |
Ulcer | 4 |
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + +|
Diverticulum | |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | X |
Degeneration, Cystic | 1 1 1 1 |
Hepatodiaphragmatic Nodule | X X|
Inflammation, Chronic | 2 1 1 1 1 2 1 |
Necrosis | 2|
Bile Duct, Hyperplasia | 1 2 2 2 2 1 2 2 2 1 3 2 1 2 1 3|
Hepatocyte, Vacuolization Cytoplasmic| 3 1 3 3 3 2 1 2 3|
__________________________________________________________________________|
Mesentery | + + + |
Mineralization | |
Fat, Inflammation, Chronic Active | 3 4 |
Fat, Necrosis | |
__________________________________________________________________________|
Oral Mucosa | + + |
Gingival, Dysplasia | 2 |
Gingival, Inflammation, Chronic | |
Active | 2 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | 1 |
Acinus, Atrophy | 1 2 2 1 2 2 1 1 1|
Acinus, Hyperplasia | |
Artery, Inflammation, Chronic Active | 2 3 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | 4 3 2 3 2|
Mineralization | 3 |
Ulcer | 4 4 4 4 2|
Epithelium, Hyperplasia | 3 3 3 3 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + +|
Mineralization | 3 3 2 |
Necrosis | |
Epithelium, Erosion | 2 3 2|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
_____________________________________________________________________________________________________________________|
Page 57
NTP Experiment-Test: 05188-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC SODIUM XYLENESULFONATE Date: 09/19/95
Route: SKIN APPLICATION Time: 21:28:07
_____________________________________________________________________________________________________________________
| 7| 5| 7| 6| 5| 7| 7| 6| 6| 5| 7| 7| 4| 7| 6| 7| 6| 6| 5| 7| 5| 6| 6| 6| 7|
DAY ON TEST | 0| 3| 3| 2| 7| 1| 3| 5| 0| 7| 0| 3| 3| 3| 5| 3| 2| 6| 9| 3| 7| 5| 4| 2| 0|
| 0| 8| 5| 2| 1| 8| 5| 2| 6| 3| 8| 5| 9| 5| 0| 5| 2| 6| 4| 5| 9| 3| 6| 1| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
120 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
MG/KG | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM - cont | |
| |
| |
__________________________________________________________________________|
Blood Vessel | + + + + + + + + + + + + + + + + + + +|
Mineralization | 3 4 |
Thrombosis | |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy, Chronic | 2 2 2 2 3 2 2 1 2 2 3 1 2 |
Mineralization | 3 3 |
Atrium, Thrombosis | 4 4 4 3|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + +|
Atrophy | |
Degeneration, Fatty | 2 2 1 2 1 1 2 2 3 2 2 2 2 3 1 2|
Hyperplasia | 1 1 1 1 1 2 2 |
Hypertrophy | |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 1 2 2 2 1 2|
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 2 2 |
__________________________________________________________________________|
Parathyroid Gland | + + M + + + + + + + + + + + + + + M +|
Hyperplasia | 3 2 4 3 |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + +|
Angiectasis | 4 4 2 3 3 2 3 3 4 4 1 4 4 4|
Mineralization | 3 |
Necrosis | |
Pigmentation, Hematoidin | 2 |
Pars Distalis, Atrophy | |
Pars Distalis, Cyst | 2 |
Pars Distalis, Hyperplasia | 1 1 3 |
Pars Distalis, Pigmentation, | |
Hemosiderin | 2 1 1 2 1 1 1 1 2 1 2 2|
Pars Distalis, Thrombosis | 4|
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + +|
C-Cell, Hyperplasia | 1 2 1 1 2 1 |
Follicle, Cyst | 3 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Coagulating Gland | |
Inflammation, Chronic Active | |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + +|
Atrophy | 4 3 4 2 2 3|
_____________________________________________________________________________________________________________________|
Page 58
NTP Experiment-Test: 05188-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC SODIUM XYLENESULFONATE Date: 09/19/95
Route: SKIN APPLICATION Time: 21:28:07
_____________________________________________________________________________________________________________________
| 7| 5| 7| 6| 5| 7| 7| 6| 6| 5| 7| 7| 4| 7| 6| 7| 6| 6| 5| 7| 5| 6| 6| 6| 7|
DAY ON TEST | 0| 3| 3| 2| 7| 1| 3| 5| 0| 7| 0| 3| 3| 3| 5| 3| 2| 6| 9| 3| 7| 5| 4| 2| 0|
| 0| 8| 5| 2| 1| 8| 5| 2| 6| 3| 8| 5| 9| 5| 0| 5| 2| 6| 4| 5| 9| 3| 6| 1| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
120 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
MG/KG | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
Mineralization | 3 |
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + + + + +|
Hyperplasia | |
Inflammation, Chronic Active | 2 2 2 1 4 2 2 2 2 1 2 2 2 2 3 2 2|
Duct, Cyst | 4 2 |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | 3 2 2 2 4 2 2 1 2 3 1 2 2 2 3 1 3 2 3|
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + +|
Atrophy | 3 2 2 3|
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + +|
Artery, Inflammation, Chronic | 1 1 2 1 |
Germinal Epithelium, Atrophy | 4 1 3 4 2 2 1 3|
Interstitial Cell, Hyperplasia | 2 2 1 1 1 1 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 4 3 4 4 3 4 3 3|
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + +|
Mediastinal, Pigmentation, | |
Hemosiderin | 1 1 2 2 2 1 3 1 1 2 1|
Renal, Ectasia | 2 |
Renal, Pigmentation, Hemosiderin | |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + +|
Ectasia | 4|
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + +|
Fibrosis | 3 |
Hematopoietic Cell Proliferation | 3 3 3 |
Pigmentation, Hemosiderin | 3 |
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + M + + +|
Hyperplasia, Cystic | 2 1 2 1 3 4 4 2 2 2 3 2 3 3 2 3 3 3|
Duct, Cyst | 4 3|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Epidermis, Skin, Site of Application,| |
Hyperplasia | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + +|
Fibrous Osteodystrophy | 4 3 4 3 |
__________________________________________________________________________|
Skeletal Muscle | + |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
_____________________________________________________________________________________________________________________|
Page 59
NTP Experiment-Test: 05188-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC SODIUM XYLENESULFONATE Date: 09/19/95
Route: SKIN APPLICATION Time: 21:28:07
_____________________________________________________________________________________________________________________
| 7| 5| 7| 6| 5| 7| 7| 6| 6| 5| 7| 7| 4| 7| 6| 7| 6| 6| 5| 7| 5| 6| 6| 6| 7|
DAY ON TEST | 0| 3| 3| 2| 7| 1| 3| 5| 0| 7| 0| 3| 3| 3| 5| 3| 2| 6| 9| 3| 7| 5| 4| 2| 0|
| 0| 8| 5| 2| 1| 8| 5| 2| 6| 3| 8| 5| 9| 5| 0| 5| 2| 6| 4| 5| 9| 3| 6| 1| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
120 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
MG/KG | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM - cont | |
| |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + +|
Hydrocephalus | 3 3 3 3 3 |
__________________________________________________________________________|
Peripheral Nerve | + |
__________________________________________________________________________|
Spinal Cord | + |
Axon, Degeneration | 1 |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + +|
Congestion, Acute | 4 4 4 3 4 4 4 3 4 |
Inflammation, Chronic Active | |
Inflammation, Granulomatous | 2 |
Inflammation, Suppurative | |
Mineralization | 3 3 |
Necrosis | |
Alveolar Epithelium, Hyperplasia | |
Alveolus, Hemorrhage, Acute | |
Alveolus, Infiltration Cellular, | |
Histiocyte | 1 1 1 1 1 1 |
Interstitium, Inflammation, Chronic | |
Active | 1 1 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | 4 2 |
Thrombosis | 4 |
Nasolacrimal Duct, Inflammation, | |
Suppurative | 2 2|
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM |