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TDMS Study 05188-05 Pathology Tables

                                              NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL
                                                       SODIUM XYLENESULFONATE


NTP Experiment-Test: 05188-05                                                                                     Report: PEIRPT09
Study Type: CHRONIC                                                                                               Date: 09/19/95
Route: SKIN APPLICATION                                                                                           Time: 21:28:07


                                                           CORE STUDY


       Facility:  Battelle Columbus Laboratory

       Chemical CAS #:  1300-72-7

       Lock Date:  07/13/93

       Cage Range:  All

       Reasons For Removal:    All

       Removal Date Range:     All

       Treatment Groups:       Include All

































                                                             Page   1
NTP Experiment-Test: 05188-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                       SODIUM XYLENESULFONATE                                  Date: 09/19/95  
Route: SKIN APPLICATION                                                                                           Time: 21:28:07  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 7| 7| 7| 7| 5| 6| 7| 5| 7| 6| 6| 4| 7| 6| 4| 7| 7| 6| 4| 6| 4| 7| 7|             
                             DAY ON TEST   | 3| 7| 3| 3| 3| 3| 9| 9| 3| 7| 1| 5| 5| 9| 3| 2| 8| 3| 3| 4| 2| 0| 8| 3| 3|             
                                           | 6| 4| 6| 6| 6| 6| 1| 2| 6| 5| 8| 6| 7| 0| 6| 9| 5| 6| 6| 6| 0| 5| 8| 6| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    0 MG/KG                                | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Parasite Metazoan                    |                                           X                              |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Parasite Metazoan                    |                         X                                         X      |             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Ulcer                                |                                                          3               |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Basophilic Focus                     | X     X  X  X     X  X  X  X  X     X     X        X  X        X         |             
      Clear Cell Focus                     |                                                                          |             
      Hepatodiaphragmatic Nodule           | X                 X  X              X        X     X                     |             
      Inflammation, Chronic                | 1     2     2        1  1        1  2  1                 2  1            |             
      Necrosis                             |    3                                                     3               |             
      Pigmentation, Hemosiderin            |                            2                             2               |             
      Pigmentation, Melanin                |                   2                                                      |             
      Bile Duct, Hyperplasia               |    3        2     1        2  2  1  1     1  1     2  1  2  1           1|             
      Central Vein, Thrombosis             |    3                                                                     |             
      Hepatocyte, Hyperplasia              |                               3                                          |             
      Hepatocyte, Vacuolization Cytoplasmic| 1     2  2     4     1  1     1     2     1                          1   |             
      Hepatocyte, Centrilobular,           |                                                                          |             
          Degeneration, Fatty              |    4                                         4                           |             
                                            __________________________________________________________________________|             
   Mesentery                               |    +                                                                     |             
      Mineralization                       |                                                                          |             
      Fat, Inflammation, Chronic Active    |    2                                                                     |             
      Fat, Necrosis                        |                                                                          |             
                                            __________________________________________________________________________|             
   Oral Mucosa                             |                                                                          |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Acinus, Atrophy                      | 1     1                 1  2     3              1     1              1  1|             
      Artery, Inflammation, Chronic Active |                3                                                         |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic Active         |    3                                                                     |             
      Ulcer                                |    4                                                                     |             
      Epithelium, Hyperplasia              |                3                                                         |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Mineralization                       |                3                                                         |             
      Necrosis                             |                4                                                         |             
      Epithelium, Erosion                  |                                                          3               |             
      Epithelium, Hemorrhage               |    2                                                                     |             
      Epithelium, Necrosis                 |    4                                                                     |             
                                            __________________________________________________________________________|             
   Tooth                                   |                                                       +                  |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   2                                                               
NTP Experiment-Test: 05188-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                       SODIUM XYLENESULFONATE                                  Date: 09/19/95  
Route: SKIN APPLICATION                                                                                           Time: 21:28:07  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 7| 7| 7| 7| 5| 6| 7| 5| 7| 6| 6| 4| 7| 6| 4| 7| 7| 6| 4| 6| 4| 7| 7|             
                             DAY ON TEST   | 3| 7| 3| 3| 3| 3| 9| 9| 3| 7| 1| 5| 5| 9| 3| 2| 8| 3| 3| 4| 2| 0| 8| 3| 3|             
                                           | 6| 4| 6| 6| 6| 6| 1| 2| 6| 5| 8| 6| 7| 0| 6| 9| 5| 6| 6| 6| 0| 5| 8| 6| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    0 MG/KG                                | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
                                           |                                                                          |             
      Peridontal Tissue, Inflammation,     |                                                                          |             
           Chronic Active                  |                                                       3                  |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood Vessel                            | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Mineralization                       |                3                                                         |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cardiomyopathy, Chronic              |          2     3     2        3  2        1           1              2   |             
      Mineralization                       |                2                                                         |             
      Atrium, Thrombosis                   |    4                                                     4               |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Accessory Adrenal Cortical Nodule    |                                                                         3|             
      Atrophy                              |                                              2                           |             
      Degeneration, Fatty                  | 1     2        2  1  1  3                 3        2     3           1   |             
      Hyperplasia                          | 1     2     2  1  1  1  2                    1  1                    2   |             
      Hypertrophy                          |                1                                                         |             
      Necrosis                             |                                                                          |             
      Pigmentation, Hemosiderin            |                                                                          |             
      Pigmentation, Lipofuscin             |                         1                    2                           |             
                                            __________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |    3           1                 1           1                           |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                               2                                          |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                3                                                         |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          | 3     2  3  3  3  4  4  4  4  2  3  2     2  1  3  3        4  2     3   |             
      Mineralization                       |                2                                                         |             
      Pigmentation, Hematoidin             |                   2                                                      |             
      Pars Distalis, Atypia Cellular       |                                                                          |             
      Pars Distalis, Cyst                  |    2  2  2  2                       3                    3               |             
      Pars Distalis, Hyperplasia           |    2                          2                                          |             
      Pars Distalis, Pigmentation,         |                                                                          |             
          Hemosiderin                      | 2        1  1  1  2  3  1  1     1  2     2  2  2  2        1  1     2  2|             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Ultimobranchial Cyst                 |                                                                          |             
      C-Cell, Hyperplasia                  | 1                                                        1              1|             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   3                                                               
NTP Experiment-Test: 05188-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                       SODIUM XYLENESULFONATE                                  Date: 09/19/95  
Route: SKIN APPLICATION                                                                                           Time: 21:28:07  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 7| 7| 7| 7| 5| 6| 7| 5| 7| 6| 6| 4| 7| 6| 4| 7| 7| 6| 4| 6| 4| 7| 7|             
                             DAY ON TEST   | 3| 7| 3| 3| 3| 3| 9| 9| 3| 7| 1| 5| 5| 9| 3| 2| 8| 3| 3| 4| 2| 0| 8| 3| 3|             
                                           | 6| 4| 6| 6| 6| 6| 1| 2| 6| 5| 8| 6| 7| 0| 6| 9| 5| 6| 6| 6| 0| 5| 8| 6| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    0 MG/KG                                | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Clitoral Gland                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +|             
      Hyperplasia                          |             2                                                            |             
      Inflammation, Chronic Active         | 2           2                 2                                2         |             
      Duct, Cyst                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                                                          |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                                                      4   |             
                                            __________________________________________________________________________|             
   Vagina                                  |    +                                                                     |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |    3           4           3  4     3        3  4  4     4              4|             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +     +  +  +  +|             
      Mediastinal, Pigmentation,           |                                                                          |             
          Hemosiderin                      | 2  1  1  1  2  1  1  2  2  2     1  2  2  2  1  2  1  2  1     2  2  1   |             
      Pancreatic, Pigmentation, Hemosiderin|                                                                          |             
      Renal, Pigmentation, Hemosiderin     |                                              3                           |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Pigmentation, Hemosiderin            |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Ectasia                              |    3                                                                     |             
      Inflammation, Suppurative            |    3                                                                     |             
      Pigmentation, Hemosiderin            |                                                                          |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Accessory Spleen                     |                                                                          |             
      Fibrosis                             |                                                          2               |             
      Hematopoietic Cell Proliferation     |                2                                                         |             
      Pigmentation, Hemosiderin            |                                                          2               |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                        2                                 |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Cystic                  | 2  3  2  2  3  2  2  2  2  2  3  1  3     2  3  2  2  1  2  2  2  1  3  3|             
      Duct, Cyst                           |                                                                          |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Epidermis, Skin, Site of Application,|                                                                          |             
           Hyperplasia                     |                                                             2            |             
      Epidermis, Skin, Site of Application,|                                                                          |             
           Ulcer                           |                                                             3            |             
      Sebaceous Gland, Skin, Site of       |                                                                          |             
          Application, Hyperplasia         |                                                             2            |             
      Skin, Site of Application,           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   4                                                               
NTP Experiment-Test: 05188-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                       SODIUM XYLENESULFONATE                                  Date: 09/19/95  
Route: SKIN APPLICATION                                                                                           Time: 21:28:07  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 7| 7| 7| 7| 5| 6| 7| 5| 7| 6| 6| 4| 7| 6| 4| 7| 7| 6| 4| 6| 4| 7| 7|             
                             DAY ON TEST   | 3| 7| 3| 3| 3| 3| 9| 9| 3| 7| 1| 5| 5| 9| 3| 2| 8| 3| 3| 4| 2| 0| 8| 3| 3|             
                                           | 6| 4| 6| 6| 6| 6| 1| 2| 6| 5| 8| 6| 7| 0| 6| 9| 5| 6| 6| 6| 0| 5| 8| 6| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    0 MG/KG                                | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
          Inflammation, Chronic Active     |                                                             2            |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrous Osteodystrophy               |                4                                                         |             
      Osteopetrosis                        |    3                                                                     |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage, Acute                    |                                                                          |             
      Hydrocephalus                        | 3                 3                                         2            |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Congestion, Acute                    |                   4  4  3  4     4  4  4                       4  4      |             
      Inflammation, Chronic Active         | 1                                                           1            |             
      Inflammation, Suppurative            |                                                                          |             
      Mineralization                       |                2                                                         |             
      Alveolus, Infiltration Cellular,     |                                                                          |             
           Histiocyte                      | 1     1  1  1  1     1     1     1        1     1  1     1     1         |             
      Interstitium, Inflammation, Chronic  |                                                                          |             
          Active                           |                                                    1                     |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic Active         |    2                                   3                                 |             
      Nasolacrimal Duct, Inflammation,     |                                                                          |             
           Chronic Active                  | 2                                                                        |             
      Nasolacrimal Duct, Inflammation,     |                                                                          |             
           Suppurative                     |                   2                                         1           2|             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                                                                +         |             
      Cornea, Inflammation, Suppurative    |                                                                          |             
      Lens, Cataract                       |                                                                          |             
      Retina, Degeneration                 |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Mineralization                       |                                        1        1           1     1      |             
      Nephropathy, Chronic                 | 2     2  3  2  4  2  2  3  1  1  1  2  1  2     1  2  2  1  2  1     3  1|             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page   5                                                               
NTP Experiment-Test: 05188-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                       SODIUM XYLENESULFONATE                                  Date: 09/19/95  
Route: SKIN APPLICATION                                                                                           Time: 21:28:07  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 3| 4| 7| 6| 7| 7| 7| 7| 3| 6| 7| 4| 7| 7| 4| 5| 7| 7| 7| 6| 4| 7| 7| 7|            |
                             DAY ON TEST   | 4| 9| 2| 3| 9| 3| 0| 3| 3| 0| 9| 3| 0| 3| 3| 8| 4| 3| 3| 3| 8| 9| 3| 1| 3|            |
                                           | 5| 3| 0| 6| 8| 6| 8| 6| 6| 3| 3| 6| 8| 6| 2| 0| 8| 6| 6| 6| 2| 0| 6| 9| 6|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|      A     |
    0 MG/KG                                | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Parasite Metazoan                    |                X                                                         |      2     |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Parasite Metazoan                    |                            X     X                                       |      4     |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Ulcer                                |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Basophilic Focus                     | X        X     X  X  X  X        X              X  X  X  X  X  X  X  X  X|     30     |
      Clear Cell Focus                     |                      X                                                   |      1     |
      Hepatodiaphragmatic Nodule           |             X                 X                             X  X         |     10     |
      Inflammation, Chronic                | 1  2  1        1     1  1           1  2     1  2              1         |     21  1.3|
      Necrosis                             |                                                          2               |      3  2.7|
      Pigmentation, Hemosiderin            |             2                                                            |      3  2.0|
      Pigmentation, Melanin                |                                                                          |      1  2.0|
      Bile Duct, Hyperplasia               |    1  1           1  2  1     1  1           1  1  1     2        1  2  2|     28  1.4|
      Central Vein, Thrombosis             |                                                                          |      1  3.0|
      Hepatocyte, Hyperplasia              |             3                                                            |      2  3.0|
      Hepatocyte, Vacuolization Cytoplasmic|                                  1                       2  2     1  2   |     15  1.6|
      Hepatocyte, Centrilobular,           |                                                                          |            |
          Degeneration, Fatty              |             4                             4                              |      4  4.0|
                                            __________________________________________________________________________|____________|
   Mesentery                               |                                                          +               |   2        |
      Mineralization                       |                                                          3               |      1  3.0|
      Fat, Inflammation, Chronic Active    |                                                                          |      1  2.0|
      Fat, Necrosis                        |                                                          4               |      1  4.0|
                                            __________________________________________________________________________|____________|
   Oral Mucosa                             |                                                    +                     |   1        |
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Acinus, Atrophy                      |    1           2     2                                                   |     12  1.4|
      Artery, Inflammation, Chronic Active |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inflammation, Chronic Active         |             3                                                            |      2  3.0|
      Ulcer                                |             4                                                            |      2  4.0|
      Epithelium, Hyperplasia              |             3                                                            |      2  3.0|
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Mineralization                       |                                                                          |      1  3.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page   6                                                               
NTP Experiment-Test: 05188-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                       SODIUM XYLENESULFONATE                                  Date: 09/19/95  
Route: SKIN APPLICATION                                                                                           Time: 21:28:07  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 3| 4| 7| 6| 7| 7| 7| 7| 3| 6| 7| 4| 7| 7| 4| 5| 7| 7| 7| 6| 4| 7| 7| 7|            |
                             DAY ON TEST   | 4| 9| 2| 3| 9| 3| 0| 3| 3| 0| 9| 3| 0| 3| 3| 8| 4| 3| 3| 3| 8| 9| 3| 1| 3|            |
                                           | 5| 3| 0| 6| 8| 6| 8| 6| 6| 3| 3| 6| 8| 6| 2| 0| 8| 6| 6| 6| 2| 0| 6| 9| 6|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|      A     |
    0 MG/KG                                | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
                                           |                                                                          |            |
      Necrosis                             |                                                                          |      1  4.0|
      Epithelium, Erosion                  |                                                                          |      1  3.0|
      Epithelium, Hemorrhage               |                                                                          |      1  2.0|
      Epithelium, Necrosis                 |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Tooth                                   |                                                                          |   1        |
      Peridontal Tissue, Inflammation,     |                                                                          |            |
           Chronic Active                  |                                                                          |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood Vessel                            | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Mineralization                       |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cardiomyopathy, Chronic              | 1  1     2                       2     1              1  1  1            |     16  1.6|
      Mineralization                       |                                                                          |      1  2.0|
      Atrium, Thrombosis                   |             4                             3                              |      4  3.8|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Accessory Adrenal Cortical Nodule    |                                                 2                        |      2  2.5|
      Atrophy                              |                                                                          |      1  2.0|
      Degeneration, Fatty                  | 1        1  2  2  1  1  1     1  2                 1  1     2        1  2|     24  1.6|
      Hyperplasia                          |                   1  1  1     2                 1     1              1   |     17  1.3|
      Hypertrophy                          |                                                                          |      1  1.0|
      Necrosis                             |                                           3                              |      1  3.0|
      Pigmentation, Hemosiderin            |                2                                                         |      1  2.0|
      Pigmentation, Lipofuscin             |                                                 2                        |      3  1.7|
                                            __________________________________________________________________________|____________|
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia                          |             1        1                                1  1              1|      9  1.2|
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia                          |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Hyperplasia                          |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Angiectasis                          |       4  2  2     1     3     4     2  2  2  4  3  2  1     3     2  4  4|     36  2.8|
      Mineralization                       |                                                                          |      1  2.0|
      Pigmentation, Hematoidin             |                                                                          |      1  2.0|
      Pars Distalis, Atypia Cellular       |                      2                                                   |      1  2.0|
      Pars Distalis, Cyst                  | 1           2  2  2  2  2  1     2  1  2  2           1  2     1  2      |     21  1.9|
      Pars Distalis, Hyperplasia           | 2                    2           2     2              2  2     2         |      9  2.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page   7                                                               
NTP Experiment-Test: 05188-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                       SODIUM XYLENESULFONATE                                  Date: 09/19/95  
Route: SKIN APPLICATION                                                                                           Time: 21:28:07  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 3| 4| 7| 6| 7| 7| 7| 7| 3| 6| 7| 4| 7| 7| 4| 5| 7| 7| 7| 6| 4| 7| 7| 7|            |
                             DAY ON TEST   | 4| 9| 2| 3| 9| 3| 0| 3| 3| 0| 9| 3| 0| 3| 3| 8| 4| 3| 3| 3| 8| 9| 3| 1| 3|            |
                                           | 5| 3| 0| 6| 8| 6| 8| 6| 6| 3| 3| 6| 8| 6| 2| 0| 8| 6| 6| 6| 2| 0| 6| 9| 6|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|      A     |
    0 MG/KG                                | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 __________________________________________________________________________________________________________________________________ 
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
                                           |                                                                          |            |
      Pars Distalis, Pigmentation,         |                                                                          |            |
          Hemosiderin                      |          2  2     1  1  2     2        1     2  2  2        1     2  2  2|     32  1.7|
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Ultimobranchial Cyst                 |                                                 2                        |      1  2.0|
      C-Cell, Hyperplasia                  |                         1              1        1        2               |      7  1.1|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Clitoral Gland                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Hyperplasia                          |                                        2                                 |      2  2.0|
      Inflammation, Chronic Active         |                                              1           1               |      6  1.7|
      Duct, Cyst                           |                                                          4               |      1  4.0|
                                            __________________________________________________________________________|____________|
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cyst                                 |                                     2              3           2         |      3  2.3|
                                            __________________________________________________________________________|____________|
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cyst                                 |                                                    3                     |      2  3.5|
                                            __________________________________________________________________________|____________|
   Vagina                                  |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia                          |             4     3     4     4           4              3     4  4     4|     19  3.7|
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +     +  +  +  +  +  +  +  +  +  +  +     +  +     +  +  +  +  +  +  +  +|  45        |
      Mediastinal, Pigmentation,           |                                                                          |            |
          Hemosiderin                      | 1     2  2  1  2  2  1  1  1  1  1  1     2  1     2  1  1  2  2  2  1  1|     44  1.5|
      Pancreatic, Pigmentation, Hemosiderin|                                                          2               |      1  2.0|
      Renal, Pigmentation, Hemosiderin     |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Pigmentation, Hemosiderin            |                                                             1        1   |      2  1.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Ectasia                              |                                                                          |      1  3.0|
      Inflammation, Suppurative            |                                                                          |      1  3.0|
      Pigmentation, Hemosiderin            |             2                                                            |      1  2.0|
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Accessory Spleen                     |                         X        X                                       |      2     |
      Fibrosis                             |                                                                      3  3|      3  2.7|
      Hematopoietic Cell Proliferation     |                                     2                                    |      2  2.0|
      Pigmentation, Hemosiderin            |                               3                       3     3            |      4  2.8|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page   8                                                               
NTP Experiment-Test: 05188-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                       SODIUM XYLENESULFONATE                                  Date: 09/19/95  
Route: SKIN APPLICATION                                                                                           Time: 21:28:07  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 3| 4| 7| 6| 7| 7| 7| 7| 3| 6| 7| 4| 7| 7| 4| 5| 7| 7| 7| 6| 4| 7| 7| 7|            |
                             DAY ON TEST   | 4| 9| 2| 3| 9| 3| 0| 3| 3| 0| 9| 3| 0| 3| 3| 8| 4| 3| 3| 3| 8| 9| 3| 1| 3|            |
                                           | 5| 3| 0| 6| 8| 6| 8| 6| 6| 3| 3| 6| 8| 6| 2| 0| 8| 6| 6| 6| 2| 0| 6| 9| 6|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|      A     |
    0 MG/KG                                | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +|  49        |
      Cyst                                 |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia, Cystic                  |       2  2     2     2  2     2  2     2  2  2     3  2  2  1  1  2  2  2|     42  2.1|
      Duct, Cyst                           |                                                    4                     |      1  4.0|
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Epidermis, Skin, Site of Application,|                                                                          |            |
           Hyperplasia                     |                                                                          |      1  2.0|
      Epidermis, Skin, Site of Application,|                                                                          |            |
           Ulcer                           |                                                                          |      1  3.0|
      Sebaceous Gland, Skin, Site of       |                                                                          |            |
          Application, Hyperplasia         |                                                                1         |      2  1.5|
      Skin, Site of Application,           |                                                                          |            |
          Inflammation, Chronic Active     |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Fibrous Osteodystrophy               |                                                                          |      1  4.0|
      Osteopetrosis                        |                                                                          |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hemorrhage, Acute                    |                                                                         4|      1  4.0|
      Hydrocephalus                        |       3                       3              2  3                       3|      8  2.8|
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Congestion, Acute                    | 3                 4           4                 4                        |     13  3.8|
      Inflammation, Chronic Active         |    1                                                                     |      3  1.0|
      Inflammation, Suppurative            |                               4                                          |      1  4.0|
      Mineralization                       |                                                                          |      1  2.0|
      Alveolus, Infiltration Cellular,     |                                                                          |            |
           Histiocyte                      | 1  1     1  1  1  1  1  1        1        1  1     1  1  1  1  1  1  1  1|     32  1.0|
      Interstitium, Inflammation, Chronic  |                                                                          |            |
          Active                           | 2                       2        1                 2  1  2        1  1   |      9  1.4|
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inflammation, Chronic Active         |             2                                                           2|      4  2.3|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page   9                                                               
NTP Experiment-Test: 05188-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                       SODIUM XYLENESULFONATE                                  Date: 09/19/95  
Route: SKIN APPLICATION                                                                                           Time: 21:28:07  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 3| 4| 7| 6| 7| 7| 7| 7| 3| 6| 7| 4| 7| 7| 4| 5| 7| 7| 7| 6| 4| 7| 7| 7|            |
                             DAY ON TEST   | 4| 9| 2| 3| 9| 3| 0| 3| 3| 0| 9| 3| 0| 3| 3| 8| 4| 3| 3| 3| 8| 9| 3| 1| 3|            |
                                           | 5| 3| 0| 6| 8| 6| 8| 6| 6| 3| 3| 6| 8| 6| 2| 0| 8| 6| 6| 6| 2| 0| 6| 9| 6|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|      A     |
    0 MG/KG                                | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 __________________________________________________________________________________________________________________________________ 
 RESPIRATORY SYSTEM - cont                 |                                                                          |            |
                                           |                                                                          |            |
      Nasolacrimal Duct, Inflammation,     |                                                                          |            |
           Chronic Active                  |                                                                          |      1  2.0|
      Nasolacrimal Duct, Inflammation,     |                                                                          |            |
           Suppurative                     |       2                       2     2        1  3                 1  2   |     10  1.8|
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Eye                                     |                               +                             +            |   3        |
      Cornea, Inflammation, Suppurative    |                               3                                          |      1  3.0|
      Lens, Cataract                       |                                                             3            |      1  3.0|
      Retina, Degeneration                 |                                                             3            |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Mineralization                       |    1  1                    1        1        1                 1         |     10  1.0|
      Nephropathy, Chronic                 | 2     1  2  1  2     2  2  1  2  2  1  1  1  1  3  2  1  2  2     2  2  1|     44  1.8|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  10                                                               
NTP Experiment-Test: 05188-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                       SODIUM XYLENESULFONATE                                  Date: 09/19/95  
Route: SKIN APPLICATION                                                                                           Time: 21:28:07  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 2| 7| 7| 5| 6| 6| 6| 7| 4| 5| 6| 7| 7| 7| 7| 4| 7| 7| 6| 7| 7| 4| 6| 6|             
                             DAY ON TEST   | 8| 7| 3| 3| 2| 4| 2| 6| 3| 4| 9| 4| 0| 3| 3| 3| 9| 3| 3| 2| 3| 3| 4| 4| 4|             
                                           | 5| 7| 6| 6| 8| 4| 6| 6| 5| 7| 0| 3| 8| 6| 6| 6| 7| 6| 6| 2| 6| 6| 6| 5| 5|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    60 MG/KG                               | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +     +  +  +  +  +  +  +  +  +           +        +        +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +     +  +  +  +  +  +  +  +  +           +        +        +  +  +|             
      Parasite Metazoan                    |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +     +  +  +  +  +  +  +  +  +           +        +        +  +  +|             
      Parasite Metazoan                    |                                     X                                    |             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +     +  +  +  +  +  +  +  +  +           +        +        +  +  +|             
      Inflammation, Chronic Active         |                         2                                                |             
      Ulcer                                |                         3                                                |             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +     +  +  +  +  +  +  +  +  +           +        +        +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +     +  +  +  +  +  +  +  +  +           +        +        +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +     +  +  +  +  +  +  +  +  +           +        +        +  +  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +     +  +  +  +  +  +  +  +  +           +        +        +  +  +|             
      Basophilic Focus                     |       X     X  X  X              X  X                    X               |             
      Hepatodiaphragmatic Nodule           |    X           X           X                                             |             
      Inflammation, Chronic                | 2     1                    1  1     2                    1           2   |             
      Necrosis                             |                      2                                                   |             
      Pigmentation, Hemosiderin            |                         2                                                |             
      Bile Duct, Hyperplasia               | 1     2     1     1     2     1  1  1                                   1|             
      Hepatocyte, Centrilobular,           |                                                                          |             
          Degeneration, Fatty              |                         3                                                |             
                                            __________________________________________________________________________|             
   Mesentery                               |                      +     +        +                                    |             
      Artery, Inflammation, Chronic Active |                                     3                                    |             
      Fat, Inflammation, Chronic Active    |                            4                                             |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +     +  +  +  +  +  +  +  +  +           +        +        +  +  +|             
      Inflammation, Chronic Active         |                                                                          |             
      Acinus, Atrophy                      |                                  1                                   1   |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +     +  +  +  +  +  +  +  +  +           +        +        +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +     +  +  +  +  +  +  +  +  +           +        +        +  +  +|             
      Inflammation, Chronic Active         |                      3  2                                         2      |             
      Ulcer                                |                      4  3                                                |             
      Epithelium, Hyperplasia              |                      3                                            3      |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +     +  +  +  +  +  +  +  +  +           +        +        +  +  +|             
      Inflammation, Chronic Active         |                      2                                                   |             
      Necrosis                             |                      3                                                   |             
      Epithelium, Erosion                  |                         3                                                |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood Vessel                            | +  +  +     +  +  +  +  +  +  +  +  +           +        +        +  +  +|             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +     +  +  +  +  +  +  +  +  +           +        +        +  +  +|             
      Cardiomyopathy, Chronic              |       3        2              1  2                       1              1|             
      Atrium, Thrombosis                   |                         4                                                |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +     +  +  +  +  +  +  +  +  +           +        +        +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  11                                                               
NTP Experiment-Test: 05188-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                       SODIUM XYLENESULFONATE                                  Date: 09/19/95  
Route: SKIN APPLICATION                                                                                           Time: 21:28:07  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 2| 7| 7| 5| 6| 6| 6| 7| 4| 5| 6| 7| 7| 7| 7| 4| 7| 7| 6| 7| 7| 4| 6| 6|             
                             DAY ON TEST   | 8| 7| 3| 3| 2| 4| 2| 6| 3| 4| 9| 4| 0| 3| 3| 3| 9| 3| 3| 2| 3| 3| 4| 4| 4|             
                                           | 5| 7| 6| 6| 8| 4| 6| 6| 5| 7| 0| 3| 8| 6| 6| 6| 7| 6| 6| 2| 6| 6| 6| 5| 5|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    60 MG/KG                               | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
      Degeneration, Fatty                  | 1     3     2     1  1  2        1                       1           1  1|             
      Hyperplasia                          | 1     3                                                  1           1  2|             
      Pigmentation, Lipofuscin             |                1        2                                                |             
                                            __________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +     +  +  +  +  +  +  +  +  +           +        +        +  +  +|             
      Hyperplasia                          |                      1  1                                2               |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +     +  +  +  +  +  +  +  +  +           +        +        +  +  +|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +     +  +  +  +  M  +  M  +  M           +        +        +  +  +|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +     +  +  +  +  +  +  +  +  +           +        +        +  +  +|             
      Angiectasis                          |       2     2        1     2  2  3  4           2        3           4  4|             
      Pigmentation, Hematoidin             |                                                                      2   |             
      Pars Distalis, Cyst                  | 2                    2  2        2              3                        |             
      Pars Distalis, Hyperplasia           |    2        2  2     2  2  2                    2                        |             
      Pars Distalis, Pigmentation,         |                                                                          |             
          Hemosiderin                      |       1     2        1  2     2  3  1                    2           2  2|             
      Pars Distalis, Thrombosis            |                                                                          |             
      Pars Intermedia, Cyst                |                            2                                             |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +     +  +  +  +  +  +  +  +  +           +        +        +  +  +|             
      C-Cell, Hyperplasia                  |                   2                                                      |             
      Follicle, Cyst                       |       2                                                                  |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Clitoral Gland                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                                                          |             
      Inflammation, Chronic Active         |                   3     1                                               1|             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +     +  +  +  +  +  +  +  +  +           +        +        +  +  +|             
      Cyst                                 | 4                                                                        |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +     +  +  +  +  +  +  +  +  +           +        +        +  +  +|             
                                            __________________________________________________________________________|             
   Vagina                                  |                      +                                                   |             
      Inflammation, Suppurative            |                      3                                                   |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +     +  +  +  +  +  +  +  +  +           +        +        +  +  +|             
      Hyperplasia                          |                      4  3                                         3      |             
                                            __________________________________________________________________________|             
   Lymph Node                              |    +  +     +  +  +  +  +  +  +  +  +           +        +        +  +  +|             
      Mediastinal, Pigmentation,           |                                                                          |             
          Hemosiderin                      |    1  1     2  1  1  2  2  2  2  1  2                    1        1  1  2|             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +     +  +  +  +  +  +  +  +  +           +        +        +  +  +|             
      Pigmentation, Hemosiderin            | 1           1                                            1               |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +     +  +  +  +  +  +  +  +  +           +        +        +  +  +|             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +     +  +  +  +  +  +  +  +  +           +        +        +  +  +|             
      Hematopoietic Cell Proliferation     |                                                                   4      |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  12                                                               
NTP Experiment-Test: 05188-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                       SODIUM XYLENESULFONATE                                  Date: 09/19/95  
Route: SKIN APPLICATION                                                                                           Time: 21:28:07  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 2| 7| 7| 5| 6| 6| 6| 7| 4| 5| 6| 7| 7| 7| 7| 4| 7| 7| 6| 7| 7| 4| 6| 6|             
                             DAY ON TEST   | 8| 7| 3| 3| 2| 4| 2| 6| 3| 4| 9| 4| 0| 3| 3| 3| 9| 3| 3| 2| 3| 3| 4| 4| 4|             
                                           | 5| 7| 6| 6| 8| 4| 6| 6| 5| 7| 0| 3| 8| 6| 6| 6| 7| 6| 6| 2| 6| 6| 6| 5| 5|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    60 MG/KG                               | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Necrosis                             |                                                 4                        |             
      Pigmentation, Hemosiderin            |                               3  3  3                                    |             
      Capsule, Fibrosis                    |                                                 3                        |             
      Capsule, Inflammation, Chronic Active|                                                 2                        |             
      Lymphoid Follicle, Depletion Cellular|                         3                                                |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +     +  +  +  +  +  +  +  +  +           +        +        +  +  +|             
      Cyst                                 |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +     +  +  +  +  +  +  +  +  +           +        +        +  +  +|             
      Hyperplasia, Cystic                  |    2  3     2        2  2  1     2  2           3        2        2  2  4|             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +     +  +  +  +  +  +  +  +  +           +        +        +  +  +|             
      Femur, Osteosclerosis                |                      3                                                   |             
      Tibia, Fracture                      |                                                                          |             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |                                                                          |             
      Inflammation, Chronic Active         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +     +  +  +  +  +  +  +  +  +           +        +        +  +  +|             
      Hydrocephalus                        |                                                          3           3  3|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +     +  +  +  +  +  +  +  +  +           +        +        +  +  +|             
      Congestion, Acute                    |    4           4           4  4  4  4                                    |             
      Inflammation, Chronic Active         |                                                                   1      |             
      Alveolar Epithelium, Hyperplasia     |                                                                      1   |             
      Alveolus, Infiltration Cellular,     |                                                                          |             
           Histiocyte                      | 2     1     1  1     1  1  1  1  1  1           2        1           1  1|             
      Interstitium, Inflammation, Chronic  |                                                                          |             
          Active                           |       2                          1                                      1|             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +     +  +  +  +  +  +  +  +  +           +        +        +  +  +|             
      Nasolacrimal Duct, Inflammation,     |                                                                          |             
           Suppurative                     |                                                                         2|             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +     +  +  +  +  +  +  +  +  +           +        +        +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                                                          +               |             
      Lens, Cataract                       |                                                          4               |             
      Retina, Degeneration                 |                                                          4               |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  13                                                               
NTP Experiment-Test: 05188-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                       SODIUM XYLENESULFONATE                                  Date: 09/19/95  
Route: SKIN APPLICATION                                                                                           Time: 21:28:07  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 2| 7| 7| 5| 6| 6| 6| 7| 4| 5| 6| 7| 7| 7| 7| 4| 7| 7| 6| 7| 7| 4| 6| 6|             
                             DAY ON TEST   | 8| 7| 3| 3| 2| 4| 2| 6| 3| 4| 9| 4| 0| 3| 3| 3| 9| 3| 3| 2| 3| 3| 4| 4| 4|             
                                           | 5| 7| 6| 6| 8| 4| 6| 6| 5| 7| 0| 3| 8| 6| 6| 6| 7| 6| 6| 2| 6| 6| 6| 5| 5|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    60 MG/KG                               | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +     +  +  +  +  +  +  +  +  +           +        +        +  +  +|             
      Infarct                              |                      3                                                   |             
      Mineralization                       | 1  1        1  1        1  1     1  1           1                 1  1   |             
      Nephropathy, Chronic                 | 1     2     1  1  1     2     2  2  1                    2           2  2|             
      Pelvis, Transitional Epithelium,     |                                                                          |             
           Hyperplasia                     |             4                                                            |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +     +  +  +  +  +  +  +  +  +           +        +        +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  14                                                               
NTP Experiment-Test: 05188-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                       SODIUM XYLENESULFONATE                                  Date: 09/19/95  
Route: SKIN APPLICATION                                                                                           Time: 21:28:07  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 3| 5| 7| 5| 7| 5| 7| 3| 5| 2| 5| 7| 3| 7| 7| 5| 5| 7| 7| 5| 5| 4| 6| 7| 6|            |
                             DAY ON TEST   | 6| 2| 3| 4| 3| 3| 0| 0| 4| 0| 8| 2| 8| 3| 3| 6| 2| 3| 3| 5| 5| 8| 3| 3| 9|            |
                                           | 7| 5| 6| 7| 6| 7| 1| 1| 1| 1| 2| 2| 6| 6| 6| 3| 8| 6| 6| 9| 0| 6| 0| 6| 4|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3|      A     |
    60 MG/KG                               | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +     +     +  +  +  +  +  +  +  +        +  +        +  +  +  +     +|  35        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +     +     +  +  +  +  +  +  +  +        +  +        +  +  +  +     +|  35        |
      Parasite Metazoan                    |                      X                                                   |      1     |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +     +     +  +  +  +  +  +  +  +        +  +        +  +  +  +     +|  35        |
      Parasite Metazoan                    |          X                 X                                             |      3     |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +     +     +  +  +  +  +  +  +  +        +  +        +  +  +  +     +|  35        |
      Inflammation, Chronic Active         |                                                                          |      1  2.0|
      Ulcer                                |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +     +     +  +  +  +  +  +  +  +        +  +        +  +  +  +     +|  35        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +     +     +  +  +  +  +  +  +  +        +  +        +  +  +  +     +|  35        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +     +     +  +  +  +  +  +  +  +        +  +        +  +  +  +     +|  35        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +     +     +  +  +  +  +  +  +  +        +  +        +  +  +  +     +|  35        |
      Basophilic Focus                     |    X           X                 X                                X     X|     12     |
      Hepatodiaphragmatic Nodule           |          X                    X                                         X|      6     |
      Inflammation, Chronic                | 1        1     2     1           1           1           1  1  1  1      |     17  1.2|
      Necrosis                             |                                                                          |      1  2.0|
      Pigmentation, Hemosiderin            |                                                                          |      1  2.0|
      Bile Duct, Hyperplasia               |          2     2              1  1                                       |     13  1.3|
      Hepatocyte, Centrilobular,           |                                                                          |            |
          Degeneration, Fatty              |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Mesentery                               |                                                                +         |   4        |
      Artery, Inflammation, Chronic Active |                                                                          |      1  3.0|
      Fat, Inflammation, Chronic Active    |                                                                3         |      2  3.5|
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +     +     +  +  +  +  +  +  +  +        +  +        +  +  +  +     +|  35        |
      Inflammation, Chronic Active         |                                  1                                       |      1  1.0|
      Acinus, Atrophy                      |                         1                                                |      3  1.0|
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +     +     +  +  +  +  +  +  +  +        +  +        +  +  +  +     +|  35        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +     +     +  +  +  +  +  +  +  +        +  +        +  +  +  +     +|  35        |
      Inflammation, Chronic Active         |                3                                                         |      4  2.5|
      Ulcer                                |                                                                          |      2  3.5|
      Epithelium, Hyperplasia              |                2              3                                          |      4  2.8|
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +     +     +  +  +  +  +  +  +  +        +  +        +  +  +  +     +|  35        |
      Inflammation, Chronic Active         |                                                                          |      1  2.0|
      Necrosis                             |                                                                          |      1  3.0|
      Epithelium, Erosion                  |                                                                          |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood Vessel                            | +  +     +     +  +  +  +  +  +  +  +        +  +        +  +  +  +     +|  35        |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +     +     +  +  +  +  +  +  +  +        +  +        +  +  +  +     +|  35        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  15                                                               
NTP Experiment-Test: 05188-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                       SODIUM XYLENESULFONATE                                  Date: 09/19/95  
Route: SKIN APPLICATION                                                                                           Time: 21:28:07  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 3| 5| 7| 5| 7| 5| 7| 3| 5| 2| 5| 7| 3| 7| 7| 5| 5| 7| 7| 5| 5| 4| 6| 7| 6|            |
                             DAY ON TEST   | 6| 2| 3| 4| 3| 3| 0| 0| 4| 0| 8| 2| 8| 3| 3| 6| 2| 3| 3| 5| 5| 8| 3| 3| 9|            |
                                           | 7| 5| 6| 7| 6| 7| 1| 1| 1| 1| 2| 2| 6| 6| 6| 3| 8| 6| 6| 9| 0| 6| 0| 6| 4|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3|      A     |
    60 MG/KG                               | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 __________________________________________________________________________________________________________________________________ 
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |            |
                                           |                                                                          |            |
      Cardiomyopathy, Chronic              |                                  1           1  1                       3|     10  1.6|
      Atrium, Thrombosis                   |                                                                          |      1  4.0|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Cortex                          | +  +     +     +  +  +  +  +  +  +  +        +  +        +  +  +  +     +|  35        |
      Degeneration, Fatty                  |                                                             2           1|     12  1.4|
      Hyperplasia                          |                2        1        3                          1           1|     10  1.6|
      Pigmentation, Lipofuscin             |                                                                          |      2  1.5|
                                            __________________________________________________________________________|____________|
   Adrenal Medulla                         | +  +     +     +  +  +  +  +  +  +  +        +  +        +  +  +  +     +|  35        |
      Hyperplasia                          |                                                                          |      3  1.3|
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +     +     +  +  +  +  +  +  +  +        +  +        +  +  +  +     +|  35        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +     +     +  +  +  +  +  +  +  +        +  +        +  +  +  +     +|  32        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +     +     +  +  +  +  +  +  +  +        +  +        +  +  +  +     +|  35        |
      Angiectasis                          |    2     4     4        4        2              1           3  3  2     3|     21  2.7|
      Pigmentation, Hematoidin             |                                                                          |      1  2.0|
      Pars Distalis, Cyst                  |                   2  1                       2           2        2     4|     11  2.2|
      Pars Distalis, Hyperplasia           |                   2                             2        2        2      |     11  2.0|
      Pars Distalis, Pigmentation,         |                                                                          |            |
          Hemosiderin                      |    2     2     2        3        1              1        1  2     1     2|     20  1.8|
      Pars Distalis, Thrombosis            |                               4                                          |      1  4.0|
      Pars Intermedia, Cyst                |                                  4                                       |      2  3.0|
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +     +     +  +  +  +  +  +  +  +        +  +        +  +  +  +     +|  35        |
      C-Cell, Hyperplasia                  |                               1  3              2                 3      |      5  2.2|
      Follicle, Cyst                       |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Clitoral Gland                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia                          |             1                                         2                  |      2  1.5|
      Inflammation, Chronic Active         |                               3                                          |      4  2.0|
                                            __________________________________________________________________________|____________|
   Ovary                                   | +  +     +     +  +  +  +  +  +  +  +        +  +        +  +  +  +     +|  35        |
      Cyst                                 |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Uterus                                  | +  +     +     +  +  +  +  +  +  +  +        +  +        +  +  +  +     +|  35        |
                                            __________________________________________________________________________|____________|
   Vagina                                  |                                                                          |   1        |
      Inflammation, Suppurative            |                                                                          |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  16                                                               
NTP Experiment-Test: 05188-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                       SODIUM XYLENESULFONATE                                  Date: 09/19/95  
Route: SKIN APPLICATION                                                                                           Time: 21:28:07  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 3| 5| 7| 5| 7| 5| 7| 3| 5| 2| 5| 7| 3| 7| 7| 5| 5| 7| 7| 5| 5| 4| 6| 7| 6|            |
                             DAY ON TEST   | 6| 2| 3| 4| 3| 3| 0| 0| 4| 0| 8| 2| 8| 3| 3| 6| 2| 3| 3| 5| 5| 8| 3| 3| 9|            |
                                           | 7| 5| 6| 7| 6| 7| 1| 1| 1| 1| 2| 2| 6| 6| 6| 3| 8| 6| 6| 9| 0| 6| 0| 6| 4|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3|      A     |
    60 MG/KG                               | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +     +     +  +  +  +  +  +  +  +        +  +        +  +  +  +     +|  35        |
      Hyperplasia                          |                   4                                                      |      4  3.5|
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +  +     +        +  +  +     +  +  +        +  +        +  +  +  +     +|  32        |
      Mediastinal, Pigmentation,           |                                                                          |            |
          Hemosiderin                      | 1  2     2        2  2  1     1  2  2        2  1        2  2  2  1     2|     31  1.6|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +     +     +  +  +  +  +  +  +  +        +  +        +  +  +  +     +|  35        |
      Pigmentation, Hemosiderin            |                1                                                        2|      5  1.2|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +     +     +  +  +  +  +  +  +  +        +  +        +  +  +  +     +|  35        |
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +     +     +  +  +  +  +  +  +  +        +  +        +  +  +  +     +|  35        |
      Hematopoietic Cell Proliferation     |                               3                 3        3               |      4  3.3|
      Necrosis                             |                                                                          |      1  4.0|
      Pigmentation, Hemosiderin            |                3                                                  3      |      5  3.0|
      Capsule, Fibrosis                    |                                                                          |      1  3.0|
      Capsule, Inflammation, Chronic Active|                                                                          |      1  2.0|
      Lymphoid Follicle, Depletion Cellular|                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +     +     +  +  +  +  +  +  +  +        +  +        +  +  +  +     +|  35        |
      Cyst                                 |                                                          2               |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  +     +     +  +  +  +  +  +  +  +        +  +        +  +  +  +     +|  35        |
      Hyperplasia, Cystic                  |    2           3        2     2  2           2           2  2  2        3|     23  2.2|
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +     +     +  +  +  +  +  +  +  +        +  +        +  +  +  +     +|  35        |
      Femur, Osteosclerosis                |                                                                          |      1  3.0|
      Tibia, Fracture                      |                            X                                             |      1     |
                                            __________________________________________________________________________|____________|
   Skeletal Muscle                         |                            +                                             |   1        |
      Inflammation, Chronic Active         |                            3                                             |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +     +     +  +  +  +  +  +  +  +        +  +        +  +  +  +     +|  35        |
      Hydrocephalus                        |                2        3                                                |      5  2.8|
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +     +     +  +  +  +  +  +  +  +        +  +        +  +  +  +     +|  35        |
      Congestion, Acute                    | 4  4     4     4     4              4                    4     4         |     14  4.0|
      Inflammation, Chronic Active         |                      1                                                   |      2  1.0|
      Alveolar Epithelium, Hyperplasia     |                                                                          |      1  1.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  17                                                               
NTP Experiment-Test: 05188-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                       SODIUM XYLENESULFONATE                                  Date: 09/19/95  
Route: SKIN APPLICATION                                                                                           Time: 21:28:07  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 3| 5| 7| 5| 7| 5| 7| 3| 5| 2| 5| 7| 3| 7| 7| 5| 5| 7| 7| 5| 5| 4| 6| 7| 6|            |
                             DAY ON TEST   | 6| 2| 3| 4| 3| 3| 0| 0| 4| 0| 8| 2| 8| 3| 3| 6| 2| 3| 3| 5| 5| 8| 3| 3| 9|            |
                                           | 7| 5| 6| 7| 6| 7| 1| 1| 1| 1| 2| 2| 6| 6| 6| 3| 8| 6| 6| 9| 0| 6| 0| 6| 4|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3|      A     |
    60 MG/KG                               | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 __________________________________________________________________________________________________________________________________ 
 RESPIRATORY SYSTEM - cont                 |                                                                          |            |
                                           |                                                                          |            |
      Alveolus, Infiltration Cellular,     |                                                                          |            |
           Histiocyte                      |                1        1     1  1           1           2  1  1        1|     23  1.1|
      Interstitium, Inflammation, Chronic  |                                                                          |            |
          Active                           |                                                          1               |      4  1.3|
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +     +     +  +  +  +  +  +  +  +        +  +        +  +  +  +     +|  35        |
      Nasolacrimal Duct, Inflammation,     |                                                                          |            |
           Suppurative                     |                   2                                               2      |      3  2.0|
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +     +     +  +  +  +  +  +  +  +        +  +        +  +  +  +     +|  35        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Eye                                     |                                                          +               |   2        |
      Lens, Cataract                       |                                                          3               |      2  3.5|
      Retina, Degeneration                 |                                                                          |      1  4.0|
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +     +     +  +  +  +  +  +  +  +        +  +        +  +  +  +     +|  35        |
      Infarct                              |                                                                          |      1  3.0|
      Mineralization                       |    1           1     1     1     1  1        1           1  1  1        1|     22  1.0|
      Nephropathy, Chronic                 | 1  1           1        2     1  1  1        1  1           1  1  1     2|     25  1.4|
      Pelvis, Transitional Epithelium,     |                                                                          |            |
           Hyperplasia                     |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +     +     +  +  +  +  +  +  +  +        +  +        +  +  +  +     +|  35        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  18                                                               
NTP Experiment-Test: 05188-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                       SODIUM XYLENESULFONATE                                  Date: 09/19/95  
Route: SKIN APPLICATION                                                                                           Time: 21:28:07  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 6| 7| 7| 7| 5| 5| 7| 6| 6| 5| 5| 7| 7| 7| 6| 5| 7| 7| 5| 6| 7| 5| 7| 7|             
                             DAY ON TEST   | 4| 6| 0| 1| 3| 2| 4| 3| 2| 4| 1| 6| 3| 3| 3| 4| 9| 0| 3| 3| 7| 3| 6| 3| 3|             
                                           | 5| 0| 6| 2| 6| 7| 7| 6| 5| 5| 7| 4| 6| 6| 6| 3| 4| 8| 6| 2| 3| 6| 8| 6| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    120                                    | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
    MG/KG                                  | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +     +  +     +  +  +  +           +  +  +     +  +     +      |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +     +  +     +  +  +  +           +  +  +     +  +     +      |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +     +  +     +  +  +  +           +  +  +     +  +     +      |             
      Parasite Metazoan                    |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +     +  +     +  +  +  +           +  +  +     +  +     +      |             
      Inflammation, Chronic Active         |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +     +  +     +  +  +  +           +  +  +     +  +     +      |             
      Inflammation, Chronic Active         |          4                                                               |             
      Ulcer                                |          4                                                               |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +     +  +     +  +  +  +           +  +  +     +  +     +      |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +     +  +     +  +  +  +           +  +  +     +  +     +      |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +     +  +     +  +  +  +           +  +  +     +  +     +      |             
      Basophilic Focus                     |    X              X           X                    X     X               |             
      Hepatodiaphragmatic Nodule           |    X  X  X        X        X  X              X                           |             
      Inflammation, Chronic                | 1  1              1     3  3  1  1              1  1                     |             
      Necrosis                             |       2                    2                                             |             
      Bile Duct, Hyperplasia               | 1        1        1     2  2  1  1                 1        2     1      |             
      Hepatocyte, Hyperplasia              |       4                                                                  |             
      Hepatocyte, Vacuolization Cytoplasmic|                            3                             2               |             
      Hepatocyte, Centrilobular,           |                                                                          |             
          Degeneration, Fatty              |       4  3                                                               |             
                                            __________________________________________________________________________|             
   Mesentery                               |          +                 +                                      +      |             
      Mineralization                       |                            2                                             |             
      Fat, Inflammation, Chronic Active    |                                                                          |             
      Fat, Necrosis                        |                            4                                      4      |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +     +  +     +  +  +  +           +  +  +     +  +     +      |             
      Cyst                                 |                                                                          |             
      Inflammation, Chronic Active         |          4                                                               |             
      Acinus, Atrophy                      |                   2                                         2     1      |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +     +  +     +  +  +  +           +  +  +     +  +     +      |             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +     +  +     +  +  +  +           +  +  +     +  +     +      |             
      Inflammation, Chronic Active         |                         3                                                |             
      Ulcer                                |                         4                                                |             
      Epithelium, Hyperplasia              |                         2                                                |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +     +  +     +  +  +  +           +  +  +     +  +     +      |             
      Inflammation, Chronic Active         |          2                                                               |             
      Mineralization                       |                                                                          |             
      Ulcer                                |          3                                                               |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood Vessel                            | +  +  +  +     +  +     +  +  +  +           +  +  +     +  +     +      |             
      Mineralization                       |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +     +  +     +  +  +  +           +  +  +     +  +     +      |             
      Cardiomyopathy, Chronic              |    2  2                       1  1              1  2     2               |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  19                                                               
NTP Experiment-Test: 05188-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                       SODIUM XYLENESULFONATE                                  Date: 09/19/95  
Route: SKIN APPLICATION                                                                                           Time: 21:28:07  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 6| 7| 7| 7| 5| 5| 7| 6| 6| 5| 5| 7| 7| 7| 6| 5| 7| 7| 5| 6| 7| 5| 7| 7|             
                             DAY ON TEST   | 4| 6| 0| 1| 3| 2| 4| 3| 2| 4| 1| 6| 3| 3| 3| 4| 9| 0| 3| 3| 7| 3| 6| 3| 3|             
                                           | 5| 0| 6| 2| 6| 7| 7| 6| 5| 5| 7| 4| 6| 6| 6| 3| 4| 8| 6| 2| 3| 6| 8| 6| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    120                                    | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
    MG/KG                                  | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |             
                                           |                                                                          |             
      Inflammation, Chronic Active         |                            2                                             |             
      Mineralization                       |                                                                          |             
      Atrium, Thrombosis                   |       4                                                                  |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +     +  +     +  +  +  +           +  +  +     +  +     +      |             
      Accessory Adrenal Cortical Nodule    |                               2                                          |             
      Degeneration, Fatty                  |    1  3        2                                                         |             
      Hyperplasia                          |    2  2                          1           1              2            |             
      Hypertrophy                          |          3                                                               |             
      Karyomegaly                          |                                                                          |             
      Pigmentation, Lipofuscin             |                         2  2                                             |             
                                            __________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +     +  +     +  +  +  +           +  +  +     +  +     +      |             
      Hyperplasia                          |                                                                          |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +     +  +     +  +  +  +           +  +  +     +  +     +      |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +     +  +     +  +  +  +           +  +  +     +  +     +      |             
      Hyperplasia                          |                                                                          |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +     +  +     +  +  +  +           +  +  +     +  +     +      |             
      Angiectasis                          |    4  2           2        2  3  3           3  2  3     2  2     2      |             
      Mineralization                       |                                                                          |             
      Pars Distalis, Cyst                  | 1  3     1                 2                    2  3        3            |             
      Pars Distalis, Hyperplasia           |       3                    2                                             |             
      Pars Distalis, Pigmentation,         |                                                                          |             
          Hemosiderin                      |    2  2           2     2  2  1  2           2  2  2     2  2            |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +     +  +     +  +  +  +           +  +  +     +  +     +      |             
      C-Cell, Hyperplasia                  |    2                                                        1            |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Clitoral Gland                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |       2                                                                  |             
      Inflammation, Chronic Active         |                            2                                             |             
      Duct, Cyst                           |    4                                                                     |             
      Duct, Hyperplasia                    |             2                                                            |             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +  +     +  +     +  +  +  +           +  +  +     +  +     +      |             
      Cyst                                 |                                                                          |             
      Inflammation, Chronic Active         |                                                                          |             
      Interstitial Cell, Hyperplasia       |                                                                          |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +     +  +     +  +  +  +           +  +  +     +  +     +      |             
      Cyst                                 |                   3                                                      |             
                                            __________________________________________________________________________|             
   Vagina                                  |    +                                                                     |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  20                                                               
NTP Experiment-Test: 05188-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                       SODIUM XYLENESULFONATE                                  Date: 09/19/95  
Route: SKIN APPLICATION                                                                                           Time: 21:28:07  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 6| 7| 7| 7| 5| 5| 7| 6| 6| 5| 5| 7| 7| 7| 6| 5| 7| 7| 5| 6| 7| 5| 7| 7|             
                             DAY ON TEST   | 4| 6| 0| 1| 3| 2| 4| 3| 2| 4| 1| 6| 3| 3| 3| 4| 9| 0| 3| 3| 7| 3| 6| 3| 3|             
                                           | 5| 0| 6| 2| 6| 7| 7| 6| 5| 5| 7| 4| 6| 6| 6| 3| 4| 8| 6| 2| 3| 6| 8| 6| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    120                                    | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
    MG/KG                                  | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +     +  +     +  +  +  +           +  +  +     +  +     +      |             
      Hyperplasia                          |       3  3     4           4                       4     4  4            |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +     +  +        +  +  +           +  +  +     +  +     +      |             
      Mediastinal, Pigmentation,           |                                                                          |             
          Hemosiderin                      | 2  2  2  1     1  2        2  1  2           2  2  1     1  1     1      |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +     +  +     +  +  +  +           +  +  +     +  +     +      |             
      Pigmentation, Hemosiderin            |       1  1        2     1                    1                           |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +     +  +     +  +  +  +           +  +  +     +  +     +      |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +     +  +     +  +  +  +           +  +  +     +  +     +      |             
      Hematopoietic Cell Proliferation     |                                                    2                     |             
      Pigmentation, Hemosiderin            |    3  3                    2                 3  3                        |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  M     +  +     +  +  +  +           +  +  +     +  +     +      |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +     +  +     +  +  +  +           +  +  +     +  +     +      |             
      Hyperplasia, Cystic                  | 2  2  2  2     2  2     1  2  2  1           2  2  2        2     1      |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperkeratosis                       |                                                                          |             
      Hyperplasia, Basal Cell              |       3                                                                  |             
      Inflammation, Chronic Active         |                                                                         3|             
      Epidermis, Hyperplasia               |                                                                         2|             
      Epidermis, Ulcer                     |                                                                         4|             
      Epidermis, Skin, Site of Application,|                                                                          |             
           Hyperplasia                     |                                                                1         |             
      Epidermis, Skin, Site of Application,|                                                                          |             
           Ulcer                           |                                                                          |             
      Sebaceous Gland, Skin, Site of       |                                                                          |             
          Application, Hyperplasia         |                                                                          |             
      Skin, Site of Application,           |                                                                          |             
          Inflammation, Chronic Active     |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +     +  +     +  +  +  +           +  +  +     +  +     +      |             
      Fibrous Osteodystrophy               |                                                                          |             
      Osteopetrosis                        |                                  3                                       |             
      Joint, Arthrosis                     |                                                                          |             
      Joint, Tarsal, Arthrosis             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +     +  +     +  +  +  +           +  +  +     +  +     +      |             
      Hydrocephalus                        |                                              3              3            |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  21                                                               
NTP Experiment-Test: 05188-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                       SODIUM XYLENESULFONATE                                  Date: 09/19/95  
Route: SKIN APPLICATION                                                                                           Time: 21:28:07  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 6| 7| 7| 7| 5| 5| 7| 6| 6| 5| 5| 7| 7| 7| 6| 5| 7| 7| 5| 6| 7| 5| 7| 7|             
                             DAY ON TEST   | 4| 6| 0| 1| 3| 2| 4| 3| 2| 4| 1| 6| 3| 3| 3| 4| 9| 0| 3| 3| 7| 3| 6| 3| 3|             
                                           | 5| 0| 6| 2| 6| 7| 7| 6| 5| 5| 7| 4| 6| 6| 6| 3| 4| 8| 6| 2| 3| 6| 8| 6| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    120                                    | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
    MG/KG                                  | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +     +  +     +  +  +  +           +  +  +     +  +     +      |             
      Congestion, Acute                    |                   4                             4                        |             
      Foreign Body                         |                                                                          |             
      Inflammation, Chronic Active         |                                                                          |             
      Mineralization                       |                                                                          |             
      Pigmentation, Hemosiderin            |                            2                                             |             
      Alveolus, Hemorrhage, Acute          |                                                                          |             
      Alveolus, Infiltration Cellular,     |                                                                          |             
           Histiocyte                      |       1  1     1        1  2  1              1  1        1        1      |             
      Interstitium, Inflammation, Chronic  |                                                                          |             
          Active                           |                   2           2                                          |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +     +  +     +  +  +  +           +  +  +     +  +     +      |             
      Inflammation, Chronic Active         |                         2                                                |             
      Nasolacrimal Duct, Inflammation,     |                                                                          |             
           Suppurative                     |                                                          2               |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +     +  +     +  +  +  +           +  +  +     +  +     +      |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                               +                                          |             
      Lens, Cataract                       |                               3                                          |             
      Retina, Degeneration                 |                               3                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +     +  +     +  +  +  +           +  +  +     +  +     +      |             
      Mineralization                       | 1                                                                        |             
      Nephropathy, Chronic                 | 1  1  1  1     1  2        3  1  1           3  1  1     1  2     1      |             
      Renal Tubule, Pigmentation,          |                                                                          |             
          Hemosiderin                      |                                                                          |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +     +  +     +  +  +  +           +  +  +     +  +     +      |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  22                                                               
NTP Experiment-Test: 05188-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                       SODIUM XYLENESULFONATE                                  Date: 09/19/95  
Route: SKIN APPLICATION                                                                                           Time: 21:28:07  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 7| 7| 6| 6| 6| 6| 6| 4| 7| 6| 7| 7| 5| 7| 6| 5| 7| 4| 5| 7| 7| 7| 5| 4|            |
                             DAY ON TEST   | 4| 3| 3| 6| 4| 0| 0| 3| 4| 1| 9| 3| 3| 1| 3| 4| 4| 3| 6| 0| 1| 3| 3| 5| 9|            |
                                           | 4| 6| 6| 6| 8| 3| 2| 8| 1| 7| 7| 6| 6| 0| 6| 6| 2| 6| 2| 1| 2| 6| 6| 9| 2|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|      A     |
    120                                    | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      L     |
    MG/KG                                  | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +        +  +  +  +  +  +  +  +        +     +  +     +  +  +        +  +|  33        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +        +  +  +  +  +  +  +  +        +     +  +     +  +  +        +  +|  33        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +        +  +  +  +  +  +  +  +        +     +  +     +  +  +        +  +|  33        |
      Parasite Metazoan                    |                                                 X                        |      1     |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +        +  +  +  +  +  +  +  +        +     +  +     +  +  +        +  +|  33        |
      Inflammation, Chronic Active         |                                        2                                 |      1  2.0|
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +        +  +  +  +  +  +  +  +        +     +  +     +  +  +        +  +|  33        |
      Inflammation, Chronic Active         |                                                                          |      1  4.0|
      Ulcer                                |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +        +  +  +  +  +  +  +  +        +     +  +     +  +  +        +  +|  33        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +        M  +  +  +  +  +  +  +        +     +  +     +  +  +        +  +|  32        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +        +  +  +  +  +  +  +  +        +     +  +     +  +  +        +  +|  33        |
      Basophilic Focus                     |             X     X  X        X              X                       X   |     11     |
      Hepatodiaphragmatic Nodule           | X        X                                   X                          X|     11     |
      Inflammation, Chronic                | 1        2                    1        1     1  1     1  1  3        1   |     19  1.4|
      Necrosis                             |                                                             2            |      3  2.0|
      Bile Duct, Hyperplasia               |                1     1     1  1        2        1        1               |     17  1.2|
      Hepatocyte, Hyperplasia              |                                                                          |      1  4.0|
      Hepatocyte, Vacuolization Cytoplasmic|                   1                    2                                 |      4  2.0|
      Hepatocyte, Centrilobular,           |                                                                          |            |
          Degeneration, Fatty              |                4                                                         |      3  3.7|
                                            __________________________________________________________________________|____________|
   Mesentery                               |                                              +                           |   4        |
      Mineralization                       |                                              3                           |      2  2.5|
      Fat, Inflammation, Chronic Active    |                                              3                           |      1  3.0|
      Fat, Necrosis                        |                                                                          |      2  4.0|
                                            __________________________________________________________________________|____________|
   Pancreas                                | +        +  +  +  +  +  +  +  +        +     +  +     +  +  +        +  +|  33        |
      Cyst                                 |                         2                                                |      1  2.0|
      Inflammation, Chronic Active         |                                                                          |      1  4.0|
      Acinus, Atrophy                      |                            3                             1               |      5  1.8|
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +        +  +  +  +  +  +  +  +        +     +  +     +  +  +        +  +|  33        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +        +  +  +  +  +  +  +  +        +     +  +     +  +  +        +  +|  33        |
      Inflammation, Chronic Active         |          2     3                                                         |      3  2.7|
      Ulcer                                |          4     4                                                         |      3  4.0|
      Epithelium, Hyperplasia              |          3     3                                                         |      3  2.7|
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +        +  +  +  +  +  +  +  +        +     +  +     +  +  +        +  +|  33        |
      Inflammation, Chronic Active         |                                                                          |      1  2.0|
      Mineralization                       |                                              3                           |      1  3.0|
      Ulcer                                |                                                                          |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  23                                                               
NTP Experiment-Test: 05188-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                       SODIUM XYLENESULFONATE                                  Date: 09/19/95  
Route: SKIN APPLICATION                                                                                           Time: 21:28:07  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 7| 7| 6| 6| 6| 6| 6| 4| 7| 6| 7| 7| 5| 7| 6| 5| 7| 4| 5| 7| 7| 7| 5| 4|            |
                             DAY ON TEST   | 4| 3| 3| 6| 4| 0| 0| 3| 4| 1| 9| 3| 3| 1| 3| 4| 4| 3| 6| 0| 1| 3| 3| 5| 9|            |
                                           | 4| 6| 6| 6| 8| 3| 2| 8| 1| 7| 7| 6| 6| 0| 6| 6| 2| 6| 2| 1| 2| 6| 6| 9| 2|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|      A     |
    120                                    | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      L     |
    MG/KG                                  | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 __________________________________________________________________________________________________________________________________ 
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |            |
                                           |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood Vessel                            | +        +  +  +  +  +  +  +  +        +     +  +     +  +  +        +  +|  33        |
      Mineralization                       |                                              3                           |      1  3.0|
                                            __________________________________________________________________________|____________|
   Heart                                   | +        +  +  +  +  +  +  +  +        +     +  +     +  +  +        +  +|  33        |
      Cardiomyopathy, Chronic              |          1           1  1  2           2     3           1           2   |     15  1.6|
      Inflammation, Chronic Active         |                                                                          |      1  2.0|
      Mineralization                       |                                              3                           |      1  3.0|
      Atrium, Thrombosis                   |                3                                                         |      2  3.5|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Cortex                          | +        +  +  +  +  +  +  +  +        +     +  +     +  +  +        +  +|  33        |
      Accessory Adrenal Cortical Nodule    |                                                                          |      1  2.0|
      Degeneration, Fatty                  |                               1              1        1     1            |      7  1.4|
      Hyperplasia                          |                               1                                          |      6  1.5|
      Hypertrophy                          |                                                                          |      1  3.0|
      Karyomegaly                          |                                              1                           |      1  1.0|
      Pigmentation, Lipofuscin             |                1                                                     2   |      4  1.8|
                                            __________________________________________________________________________|____________|
   Adrenal Medulla                         | +        +  +  +  +  +  +  +  +        +     +  +     +  +  +        +  +|  33        |
      Hyperplasia                          |                                              2                           |      1  2.0|
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +        +  +  +  +  +  +  +  +        +     +  +     +  +  +        +  +|  33        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +        +  M  +  +  +  +  +  +        M     +  +     +  +  +        +  +|  31        |
      Hyperplasia                          |                                              4                           |      1  4.0|
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +        +  +  +  +  +  +  +  +        +     +  +     +  +  +        +  +|  33        |
      Angiectasis                          |          4  3  2     2     4  3                             4            |     19  2.7|
      Mineralization                       |                                              2                           |      1  2.0|
      Pars Distalis, Cyst                  | 1        2        2  2        2              4  2        1               |     15  2.1|
      Pars Distalis, Hyperplasia           |                                        2     2  2        2           2   |      7  2.1|
      Pars Distalis, Pigmentation,         |                                                                          |            |
          Hemosiderin                      |          1  1     1  1     2           2        1           1            |     20  1.7|
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +        +  +  +  +  +  +  +  +        +     +  +     +  +  +        +  +|  33        |
      C-Cell, Hyperplasia                  |                            2           3                    1            |      5  1.8|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Clitoral Gland                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia                          |                                                                          |      1  2.0|
      Inflammation, Chronic Active         |             3                          4                                4|      4  3.3|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  24                                                               
NTP Experiment-Test: 05188-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                       SODIUM XYLENESULFONATE                                  Date: 09/19/95  
Route: SKIN APPLICATION                                                                                           Time: 21:28:07  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 7| 7| 6| 6| 6| 6| 6| 4| 7| 6| 7| 7| 5| 7| 6| 5| 7| 4| 5| 7| 7| 7| 5| 4|            |
                             DAY ON TEST   | 4| 3| 3| 6| 4| 0| 0| 3| 4| 1| 9| 3| 3| 1| 3| 4| 4| 3| 6| 0| 1| 3| 3| 5| 9|            |
                                           | 4| 6| 6| 6| 8| 3| 2| 8| 1| 7| 7| 6| 6| 0| 6| 6| 2| 6| 2| 1| 2| 6| 6| 9| 2|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|      A     |
    120                                    | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      L     |
    MG/KG                                  | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 __________________________________________________________________________________________________________________________________ 
 GENITAL SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
      Duct, Cyst                           |                      3                                                   |      2  3.5|
      Duct, Hyperplasia                    |                      2                                                   |      2  2.0|
                                            __________________________________________________________________________|____________|
   Ovary                                   | +        +  +  +  +  +  +  +  +        +     +  +     +  +  +        +  +|  33        |
      Cyst                                 |                2                                                        2|      2  2.0|
      Inflammation, Chronic Active         |                                        4                                 |      1  4.0|
      Interstitial Cell, Hyperplasia       |                            3           3                                 |      2  3.0|
                                            __________________________________________________________________________|____________|
   Uterus                                  | +        +  +  +  +  +  +  +  +        +     +  +     +  +  +        +  +|  33        |
      Cyst                                 |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Vagina                                  |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +        +  +  +  +  +  +  +  +        +     +  +     +  +  +        +  +|  33        |
      Hyperplasia                          |                4           4           3     4                          4|     12  3.8|
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +        +  +           +  +  +        +        +     +  +  +        +   |  27        |
      Mediastinal, Pigmentation,           |                                                                          |            |
          Hemosiderin                      | 1        1  2           1  2  2        1        2     2  1  1        2   |     27  1.5|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +        +  +  +  +  +  +  +  +        +     +  +     +  +  +        +  +|  33        |
      Pigmentation, Hemosiderin            |                   2                                                      |      6  1.3|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +        +  +  +  +  +  +  +  +        +     +  +     +  +  +        +  +|  33        |
                                            __________________________________________________________________________|____________|
   Spleen                                  | +        +  +  +  +  +  +  +  +        +     +  +     +  +  +        +  +|  33        |
      Hematopoietic Cell Proliferation     |                                              3                          4|      3  3.0|
      Pigmentation, Hemosiderin            |          3  3                                               3        3   |      9  2.9|
                                            __________________________________________________________________________|____________|
   Thymus                                  | +        +  +  M  +  +  +  +  +        +     +  +     +  +  +        +  +|  31        |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +        +  +  +  +  +  +  +  +        +     +  +     +  +  +        +  +|  33        |
      Hyperplasia, Cystic                  |          2     1  2  2  4  2                 2  1        2  3        2  2|     27  1.9|
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperkeratosis                       |                3                                                         |      1  3.0|
      Hyperplasia, Basal Cell              |                                                                          |      1  3.0|
      Inflammation, Chronic Active         |                                                                          |      1  3.0|
      Epidermis, Hyperplasia               |                                                                          |      1  2.0|
      Epidermis, Ulcer                     |                                                                          |      1  4.0|
      Epidermis, Skin, Site of Application,|                                                                          |            |
           Hyperplasia                     | 2                                3              1                        |      4  1.8|
      Epidermis, Skin, Site of Application,|                                                                          |            |
           Ulcer                           | 3                                3                                       |      2  3.0|
      Sebaceous Gland, Skin, Site of       |                                                                          |            |
          Application, Hyperplasia         | 2                                3                                       |      2  2.5|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  25                                                               
NTP Experiment-Test: 05188-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                       SODIUM XYLENESULFONATE                                  Date: 09/19/95  
Route: SKIN APPLICATION                                                                                           Time: 21:28:07  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 7| 7| 6| 6| 6| 6| 6| 4| 7| 6| 7| 7| 5| 7| 6| 5| 7| 4| 5| 7| 7| 7| 5| 4|            |
                             DAY ON TEST   | 4| 3| 3| 6| 4| 0| 0| 3| 4| 1| 9| 3| 3| 1| 3| 4| 4| 3| 6| 0| 1| 3| 3| 5| 9|            |
                                           | 4| 6| 6| 6| 8| 3| 2| 8| 1| 7| 7| 6| 6| 0| 6| 6| 2| 6| 2| 1| 2| 6| 6| 9| 2|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|      A     |
    120                                    | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      L     |
    MG/KG                                  | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 __________________________________________________________________________________________________________________________________ 
 INTEGUMENTARY SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
      Skin, Site of Application,           |                                                                          |            |
          Inflammation, Chronic Active     | 3                                3                                       |      2  3.0|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +        +  +  +  +  +  +  +  +        +     +  +     +  +  +        +  +|  33        |
      Fibrous Osteodystrophy               |                                              3                           |      1  3.0|
      Osteopetrosis                        |                                                                          |      1  3.0|
      Joint, Arthrosis                     |                4                                                         |      1  4.0|
      Joint, Tarsal, Arthrosis             |                3                                                         |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +        +  +  +  +  +  +  +  +        +     +  +     +  +  +        +  +|  33        |
      Hydrocephalus                        |                                                             3            |      3  3.0|
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    | +        +  +  +  +  +  +  +  +        +     +  +     +  +  +        +  +|  33        |
      Congestion, Acute                    | 4           4     4  4                                4              4   |      8  4.0|
      Foreign Body                         |                         X                                                |      1     |
      Inflammation, Chronic Active         | 1                       3                                                |      2  2.0|
      Mineralization                       |                                              3                           |      1  3.0|
      Pigmentation, Hemosiderin            |                                                                          |      1  2.0|
      Alveolus, Hemorrhage, Acute          |                                              3                           |      1  3.0|
      Alveolus, Infiltration Cellular,     |                                                                          |            |
           Histiocyte                      |          1  1  1  1           1              1  1     1     1           1|     20  1.1|
      Interstitium, Inflammation, Chronic  |                                                                          |            |
          Active                           |                                                                          |      2  2.0|
                                            __________________________________________________________________________|____________|
   Nose                                    | +        +  +  +  +  +  +  +  +        +     +  +     +  +  +        +  +|  33        |
      Inflammation, Chronic Active         |                   3                                                      |      2  2.5|
      Nasolacrimal Duct, Inflammation,     |                                                                          |            |
           Suppurative                     |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Trachea                                 | +        +  +  +  +  +  +  +  +        +     +  +     +  +  +        +  +|  33        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Eye                                     |                                                                      +   |   2        |
      Lens, Cataract                       |                                                                      4   |      2  3.5|
      Retina, Degeneration                 |                                                                      4   |      2  3.5|
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +        +  +  +  +  +  +  +  +        +     +  +     +  +  +        +  +|  33        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  26                                                               
NTP Experiment-Test: 05188-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                       SODIUM XYLENESULFONATE                                  Date: 09/19/95  
Route: SKIN APPLICATION                                                                                           Time: 21:28:07  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 7| 7| 6| 6| 6| 6| 6| 4| 7| 6| 7| 7| 5| 7| 6| 5| 7| 4| 5| 7| 7| 7| 5| 4|            |
                             DAY ON TEST   | 4| 3| 3| 6| 4| 0| 0| 3| 4| 1| 9| 3| 3| 1| 3| 4| 4| 3| 6| 0| 1| 3| 3| 5| 9|            |
                                           | 4| 6| 6| 6| 8| 3| 2| 8| 1| 7| 7| 6| 6| 0| 6| 6| 2| 6| 2| 1| 2| 6| 6| 9| 2|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|      A     |
    120                                    | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      L     |
    MG/KG                                  | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 __________________________________________________________________________________________________________________________________ 
 URINARY SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
      Mineralization                       | 1                                               1     1  1  1           1|      7  1.0|
      Nephropathy, Chronic                 |          2  1     2     1  2  2              4  1        2  2        1  1|     27  1.6|
      Renal Tubule, Pigmentation,          |                                                                          |            |
          Hemosiderin                      |                4                                                         |      1  4.0|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +        +  +  +  +  +  +  +  +        +     +  +     +  +  +        +  +|  33        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  27                                                               
NTP Experiment-Test: 05188-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                       SODIUM XYLENESULFONATE                                  Date: 09/19/95  
Route: SKIN APPLICATION                                                                                           Time: 21:28:07  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 5| 7| 7| 5| 7| 3| 7| 6| 7| 7| 2| 6| 6| 7| 3| 7| 7| 3| 7| 6| 4| 7| 5| 6|             
                             DAY ON TEST   | 9| 2| 0| 3| 2| 3| 3| 3| 7| 3| 1| 8| 9| 4| 3| 7| 3| 1| 2| 3| 4| 4| 3| 5| 9|             
                                           | 6| 6| 6| 6| 0| 6| 8| 6| 7| 6| 4| 9| 5| 6| 6| 9| 6| 1| 4| 6| 0| 1| 6| 6| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    240                                    | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|             
    MG/KG                                  | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Parasite Metazoan                    |                                  X                                      X|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Parasite Metazoan                    |                               X                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic Active         |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                                                          |             
      Basophilic Focus                     | X  X     X           X     X              X     X  X        X     X     X|             
      Clear Cell Focus                     |                                                                          |             
      Hematopoietic Cell Proliferation     |                                                    2                     |             
      Hepatodiaphragmatic Nodule           |          X                                                               |             
      Inflammation, Chronic                |       1           1  2  2           1           1           1  2  1      |             
      Mixed Cell Focus                     |                                                                          |             
      Necrosis                             |                               1        2                                 |             
      Bile Duct, Hyperplasia               | 1     1        2  1  1        1     1  1        1  1     3  1        1  1|             
      Hepatocyte, Hyperplasia              |                                                                          |             
      Hepatocyte, Vacuolization Cytoplasmic|                            1              1     1                        |             
      Hepatocyte, Centrilobular,           |                                                                          |             
          Degeneration, Fatty              |                                        4                                 |             
      Portal Vein, Thrombosis              |                                                                          |             
                                            __________________________________________________________________________|             
   Mesentery                               |             +  +                                                         |             
      Mineralization                       |             1                                                            |             
      Fat, Inflammation, Chronic Active    |             3                                                            |             
                                            __________________________________________________________________________|             
   Oral Mucosa                             |                               +                                          |             
      Gingival, Inflammation, Chronic      |                                                                          |             
          Active                           |                               3                                          |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hypertrophy, Focal                   |                                        4                                 |             
      Acinus, Atrophy                      |       2              2        1        1                                 |             
      Artery, Inflammation, Chronic Active |                                                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic Active         |                2                       3                                 |             
      Ulcer                                |                4                       4                                 |             
      Epithelium, Hyperplasia              |                2                       3           2                     |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Tooth                                   |                                                                          |             
      Inflammation                         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  28                                                               
NTP Experiment-Test: 05188-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                       SODIUM XYLENESULFONATE                                  Date: 09/19/95  
Route: SKIN APPLICATION                                                                                           Time: 21:28:07  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 5| 7| 7| 5| 7| 3| 7| 6| 7| 7| 2| 6| 6| 7| 3| 7| 7| 3| 7| 6| 4| 7| 5| 6|             
                             DAY ON TEST   | 9| 2| 0| 3| 2| 3| 3| 3| 7| 3| 1| 8| 9| 4| 3| 7| 3| 1| 2| 3| 4| 4| 3| 5| 9|             
                                           | 6| 6| 6| 6| 0| 6| 8| 6| 7| 6| 4| 9| 5| 6| 6| 9| 6| 1| 4| 6| 0| 1| 6| 6| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    240                                    | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|             
    MG/KG                                  | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |             
                                           |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood Vessel                            | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cardiomyopathy, Chronic              | 1     2                 2  1              1     1           2     1     2|             
      Atrium, Thrombosis                   |                                        4                                 |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Accessory Adrenal Cortical Nodule    |                                                                          |             
      Degeneration, Fatty                  |       1              1  1  2        1  3           2     1               |             
      Hyperplasia                          |       1              2  2  2              1        1     1  2            |             
      Hypertrophy                          |                                                 2                        |             
      Karyomegaly                          |                                     2                                    |             
      Pigmentation, Lipofuscin             |                2                       2  1                              |             
                                            __________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                2                                                     1   |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                                                          |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  M  +  +  +  +  +  +  +  +  M  +  +  +  +  M  +  +  +  +  M  +|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          | 2  2        4        3     2  4     3     3     2  2     2        3     2|             
      Pigmentation, Hematoidin             |                                                                          |             
      Pars Distalis, Cyst                  |       3  3     2  1  3  2  2           3     2  4  2     2  2  1     2   |             
      Pars Distalis, Hyperplasia           |          2     2  2  2  2              2  2                 2  3         |             
      Pars Distalis, Pigmentation,         |                                                                          |             
          Hemosiderin                      | 1  2  1     2        1  1  2  2     2     2     2  2     2  1     2      |             
      Pars Intermedia, Cyst                |                                                                          |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      C-Cell, Hyperplasia                  |                            1        1  1  1     1                        |             
      Follicle, Cyst                       |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Clitoral Gland                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          | 2              2           2        2                    2               |             
      Inflammation, Chronic Active         |                                     3                          1         |             
      Duct, Cyst                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |             4                                                           4|             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  29                                                               
NTP Experiment-Test: 05188-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                       SODIUM XYLENESULFONATE                                  Date: 09/19/95  
Route: SKIN APPLICATION                                                                                           Time: 21:28:07  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 5| 7| 7| 5| 7| 3| 7| 6| 7| 7| 2| 6| 6| 7| 3| 7| 7| 3| 7| 6| 4| 7| 5| 6|             
                             DAY ON TEST   | 9| 2| 0| 3| 2| 3| 3| 3| 7| 3| 1| 8| 9| 4| 3| 7| 3| 1| 2| 3| 4| 4| 3| 5| 9|             
                                           | 6| 6| 6| 6| 0| 6| 8| 6| 7| 6| 4| 9| 5| 6| 6| 9| 6| 1| 4| 6| 0| 1| 6| 6| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    240                                    | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|             
    MG/KG                                  | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |          4  4  4  4                    3           4           3         |             
      Inflammation, Granulomatous          |                                                       2                  |             
                                            __________________________________________________________________________|             
   Lymph Node                              |       +  +  +  +  +  +     +  +     +        +  +  +  +  +  +  +  +  +  +|             
      Lumbar, Hyperplasia, Lymphoid        |                                                                          |             
      Mediastinal, Hyperplasia, Plasma Cell|                   3                                                      |             
      Mediastinal, Pigmentation,           |                                                                          |             
          Hemosiderin                      |       2  2  2        2     2  2     2        1  1  1  1  1  2  2  2  1  1|             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Pigmentation, Hemosiderin            |                               2                                      1   |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hematopoietic Cell Proliferation     |                                                                4         |             
      Pigmentation, Hemosiderin            |    2                          2     2     2                              |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Cystic                  |    2  2  3  3  1     2  2  2  2     3  1  2     4  2     2  1  2  2  1  2|             
      Duct, Cyst                           |                                                          4               |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Epidermis, Skin, Site of Application,|                                                                          |             
           Exudate                         |                                        1                                 |             
      Epidermis, Skin, Site of Application,|                                                                          |             
           Hyperplasia                     |    1                             1                             1         |             
      Epidermis, Skin, Site of Application,|                                                                          |             
           Inflammation, Chronic Active    |                                  1                                       |             
      Epidermis, Skin, Site of Application,|                                                                          |             
           Ulcer                           |                                                                          |             
      Sebaceous Gland, Skin, Site of       |                                                                          |             
          Application, Hyperplasia         |                                                                          |             
      Skin, Site of Application,           |                                                                          |             
          Inflammation, Chronic Active     |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Femur, Osteosclerosis                |                2                                                         |             
      Femur, Tibia, Osteosclerosis         |                                        2                                 |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage, Acute                    |                                                                          |             
      Hydrocephalus                        |             3                 3     3                                    |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  30                                                               
NTP Experiment-Test: 05188-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                       SODIUM XYLENESULFONATE                                  Date: 09/19/95  
Route: SKIN APPLICATION                                                                                           Time: 21:28:07  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 5| 7| 7| 5| 7| 3| 7| 6| 7| 7| 2| 6| 6| 7| 3| 7| 7| 3| 7| 6| 4| 7| 5| 6|             
                             DAY ON TEST   | 9| 2| 0| 3| 2| 3| 3| 3| 7| 3| 1| 8| 9| 4| 3| 7| 3| 1| 2| 3| 4| 4| 3| 5| 9|             
                                           | 6| 6| 6| 6| 0| 6| 8| 6| 7| 6| 4| 9| 5| 6| 6| 9| 6| 1| 4| 6| 0| 1| 6| 6| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    240                                    | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|             
    MG/KG                                  | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Congestion, Acute                    | 4  4  4                 4     4  4        4                             4|             
      Inflammation, Chronic Active         |                                           2           1                  |             
      Inflammation, Granulomatous          |    1                                                                     |             
      Alveolar Epithelium, Hyperplasia     |                                                                          |             
      Alveolus, Infiltration Cellular,     |                                                                          |             
           Histiocyte                      | 1     1  1  1  1     1  1  1  1     1  1  1  1  1  1        1  1  1      |             
      Interstitium, Inflammation, Chronic  |                                                                          |             
          Active                           |                            2                                             |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic Active         | 2                       1                    2           2  1            |             
      Nasolacrimal Duct, Inflammation,     |                                                                          |             
           Suppurative                     |                   3                 1           1                 3      |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |       +                                                           +      |             
      Lens, Cataract                       |                                                                   4      |             
      Retina, Degeneration                 |       3                                                           4      |             
      Retina, Hemorrhage                   |                                                                          |             
                                            __________________________________________________________________________|             
   Zymbal's Gland                          |                   +                                                      |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Mineralization                       |          1        1  1     1     1           1        1                  |             
      Nephropathy, Chronic                 |    1  1  1     1     1  1  2  2     2  1  2  2  2  2     2  2     2     2|             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  31                                                               
NTP Experiment-Test: 05188-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                       SODIUM XYLENESULFONATE                                  Date: 09/19/95  
Route: SKIN APPLICATION                                                                                           Time: 21:28:07  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 7| 7| 4| 7| 7| 3| 5| 7| 6| 5| 7| 5| 6| 6| 7| 6| 3| 6| 7| 5| 6| 7| 6| 6|            |
                             DAY ON TEST   | 7| 3| 3| 1| 3| 3| 9| 9| 3| 1| 8| 3| 1| 5| 7| 3| 3| 9| 1| 2| 0| 3| 3| 3| 5|            |
                                           | 2| 6| 6| 2| 6| 6| 6| 1| 6| 1| 9| 6| 5| 1| 4| 6| 3| 1| 5| 8| 7| 0| 6| 4| 3|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4|      A     |
    240                                    | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|      L     |
    MG/KG                                  | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Parasite Metazoan                    |                                                 X                        |      3     |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Parasite Metazoan                    |       X  X                                                               |      3     |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inflammation, Chronic Active         |                                                          2               |      1  2.0|
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Angiectasis                          |                                              2                           |      1  2.0|
      Basophilic Focus                     |    X  X     X  X     X  X  X  X  X  X  X     X  X     X  X               |     26     |
      Clear Cell Focus                     |                                           X                              |      1     |
      Hematopoietic Cell Proliferation     |                                                                          |      1  2.0|
      Hepatodiaphragmatic Nodule           | X                                      X                                 |      3     |
      Inflammation, Chronic                | 1     1     1  2  3  1     2  1     1  2  2        1  2  3  1            |     24  1.5|
      Mixed Cell Focus                     |                         X                                                |      1     |
      Necrosis                             |                         4                                                |      3  2.3|
      Bile Duct, Hyperplasia               |    2                       1              1  1  2        2     2         |     21  1.3|
      Hepatocyte, Hyperplasia              |                                                          4               |      1  4.0|
      Hepatocyte, Vacuolization Cytoplasmic|                                                          3               |      4  1.5|
      Hepatocyte, Centrilobular,           |                                                                          |            |
          Degeneration, Fatty              |                                                                4         |      2  4.0|
      Portal Vein, Thrombosis              |                            2                                             |      1  2.0|
                                            __________________________________________________________________________|____________|
   Mesentery                               |                                                       +                 +|   4        |
      Mineralization                       |                                                                          |      1  1.0|
      Fat, Inflammation, Chronic Active    |                                                       3                  |      2  3.0|
                                            __________________________________________________________________________|____________|
   Oral Mucosa                             |                         +                                                |   2        |
      Gingival, Inflammation, Chronic      |                                                                          |            |
          Active                           |                         2                                                |      2  2.5|
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hypertrophy, Focal                   |                                                                          |      1  4.0|
      Acinus, Atrophy                      |             2                       1  1  1                              |      8  1.4|
      Artery, Inflammation, Chronic Active |                                                       3                  |      1  3.0|
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inflammation, Chronic Active         |                                                                      2  3|      4  2.5|
      Ulcer                                |                                                                      4   |      3  4.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  32                                                               
NTP Experiment-Test: 05188-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                       SODIUM XYLENESULFONATE                                  Date: 09/19/95  
Route: SKIN APPLICATION                                                                                           Time: 21:28:07  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 7| 7| 4| 7| 7| 3| 5| 7| 6| 5| 7| 5| 6| 6| 7| 6| 3| 6| 7| 5| 6| 7| 6| 6|            |
                             DAY ON TEST   | 7| 3| 3| 1| 3| 3| 9| 9| 3| 1| 8| 3| 1| 5| 7| 3| 3| 9| 1| 2| 0| 3| 3| 3| 5|            |
                                           | 2| 6| 6| 2| 6| 6| 6| 1| 6| 1| 9| 6| 5| 1| 4| 6| 3| 1| 5| 8| 7| 0| 6| 4| 3|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4|      A     |
    240                                    | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|      L     |
    MG/KG                                  | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
                                           |                                                                          |            |
      Epithelium, Hyperplasia              |                                                                      2  3|      5  2.4|
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Tooth                                   |                         +                                                |   1        |
      Inflammation                         |                         2                                                |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood Vessel                            | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cardiomyopathy, Chronic              |       1     2  2     2  1  1     1  1     1  1  1     2     1  2         |     23  1.4|
      Atrium, Thrombosis                   |                                                                2         |      2  3.0|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Accessory Adrenal Cortical Nodule    |                            3                                             |      1  3.0|
      Degeneration, Fatty                  |    3        2  3        1                             2                 2|     14  1.8|
      Hyperplasia                          |    1           2        2        1                    1  2     2     1  1|     17  1.5|
      Hypertrophy                          |                                                                          |      1  2.0|
      Karyomegaly                          |                                                                          |      1  2.0|
      Pigmentation, Lipofuscin             |                                  2                       2     2        1|      7  1.7|
                                            __________________________________________________________________________|____________|
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia                          |                                                    2           1        2|      5  1.6|
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia                          |                                              2                           |      1  2.0|
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  45        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Angiectasis                          | 4  3  2     2  2  4  4  3  2  4           4  2  2     4  4        2  4  1|     31  2.8|
      Pigmentation, Hematoidin             |                                           2                              |      1  2.0|
      Pars Distalis, Cyst                  |    3  2  1  2  2     4     3     1     2     2  3           1  3  2      |     29  2.2|
      Pars Distalis, Hyperplasia           |       3  2     2                 2           2  3           1  1         |     17  2.1|
      Pars Distalis, Pigmentation,         |                                                                          |            |
          Hemosiderin                      | 2  2     1           2  2     2  1  1  1  2  2  1     2  2           1  2|     31  1.6|
      Pars Intermedia, Cyst                |       2                                                        2         |      2  2.0|
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      C-Cell, Hyperplasia                  |                            2              2                             1|      8  1.3|
      Follicle, Cyst                       |                                                          3               |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  33                                                               
NTP Experiment-Test: 05188-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                       SODIUM XYLENESULFONATE                                  Date: 09/19/95  
Route: SKIN APPLICATION                                                                                           Time: 21:28:07  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 7| 7| 4| 7| 7| 3| 5| 7| 6| 5| 7| 5| 6| 6| 7| 6| 3| 6| 7| 5| 6| 7| 6| 6|            |
                             DAY ON TEST   | 7| 3| 3| 1| 3| 3| 9| 9| 3| 1| 8| 3| 1| 5| 7| 3| 3| 9| 1| 2| 0| 3| 3| 3| 5|            |
                                           | 2| 6| 6| 2| 6| 6| 6| 1| 6| 1| 9| 6| 5| 1| 4| 6| 3| 1| 5| 8| 7| 0| 6| 4| 3|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4|      A     |
    240                                    | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|      L     |
    MG/KG                                  | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 __________________________________________________________________________________________________________________________________ 
 GENITAL SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Clitoral Gland                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia                          |                         3  3                 1  2                 2      |     10  2.1|
      Inflammation, Chronic Active         |             2                             1           2        1        2|      7  1.7|
      Duct, Cyst                           |                                              3           3               |      2  3.0|
                                            __________________________________________________________________________|____________|
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cyst                                 |                   1                    3                                 |      4  3.0|
                                            __________________________________________________________________________|____________|
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  M  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +|  48        |
      Hyperplasia                          |                            4                                   4        4|     10  3.8|
      Inflammation, Granulomatous          |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  43        |
      Lumbar, Hyperplasia, Lymphoid        |                            3                                             |      1  3.0|
      Mediastinal, Hyperplasia, Plasma Cell|                                                                          |      1  3.0|
      Mediastinal, Pigmentation,           |                                                                          |            |
          Hemosiderin                      | 2  2  2  2  2  1     2  1     2  1  1  2  1  1  3  2  1  2  2  1  2  2  1|     40  1.6|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Pigmentation, Hemosiderin            |                               1                          2               |      4  1.5|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +|  48        |
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hematopoietic Cell Proliferation     |                                                                          |      1  4.0|
      Pigmentation, Hemosiderin            | 3                    3     3              3           3  3           3   |     11  2.6|
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia, Cystic                  | 2  2  2  2  2  2  2  2  2     2  2  2  2  2  2  2     4  2  1  2     2  2|     42  2.0|
      Duct, Cyst                           |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Epidermis, Skin, Site of Application,|                                                                          |            |
           Exudate                         |                                           1                              |      2  1.0|
      Epidermis, Skin, Site of Application,|                                                                          |            |
           Hyperplasia                     |    2                                   2                                 |      5  1.4|
      Epidermis, Skin, Site of Application,|                                                                          |            |
           Inflammation, Chronic Active    |                                                                          |      1  1.0|
      Epidermis, Skin, Site of Application,|                                                                          |            |
           Ulcer                           |    4                                   2                                 |      2  3.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  34                                                               
NTP Experiment-Test: 05188-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                       SODIUM XYLENESULFONATE                                  Date: 09/19/95  
Route: SKIN APPLICATION                                                                                           Time: 21:28:07  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 7| 7| 4| 7| 7| 3| 5| 7| 6| 5| 7| 5| 6| 6| 7| 6| 3| 6| 7| 5| 6| 7| 6| 6|            |
                             DAY ON TEST   | 7| 3| 3| 1| 3| 3| 9| 9| 3| 1| 8| 3| 1| 5| 7| 3| 3| 9| 1| 2| 0| 3| 3| 3| 5|            |
                                           | 2| 6| 6| 2| 6| 6| 6| 1| 6| 1| 9| 6| 5| 1| 4| 6| 3| 1| 5| 8| 7| 0| 6| 4| 3|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4|      A     |
    240                                    | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|      L     |
    MG/KG                                  | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 __________________________________________________________________________________________________________________________________ 
 INTEGUMENTARY SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
      Sebaceous Gland, Skin, Site of       |                                                                          |            |
          Application, Hyperplasia         |    2                                   2                                 |      2  2.0|
      Skin, Site of Application,           |                                                                          |            |
          Inflammation, Chronic Active     |    3                                   2                                 |      2  2.5|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  M  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +|  48        |
      Femur, Osteosclerosis                |                                                                          |      1  2.0|
      Femur, Tibia, Osteosclerosis         |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hemorrhage, Acute                    |                                                                         3|      1  3.0|
      Hydrocephalus                        |                      3                    3              3           3   |      7  3.0|
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Congestion, Acute                    | 4        4              3     3           3     4  4  4                  |     16  3.8|
      Inflammation, Chronic Active         |          1                                            2                  |      4  1.5|
      Inflammation, Granulomatous          |                                                                      1   |      2  1.0|
      Alveolar Epithelium, Hyperplasia     |       3     2                                         2              2   |      4  2.3|
      Alveolus, Infiltration Cellular,     |                                                                          |            |
           Histiocyte                      | 1  1  1     1  1     1  1  1  1  1  1  1  1  1  1     2  1  1  1     1  1|     39  1.0|
      Interstitium, Inflammation, Chronic  |                                                                          |            |
          Active                           |                1                    1                    3           1   |      5  1.6|
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inflammation, Chronic Active         |                                                       2                  |      6  1.7|
      Nasolacrimal Duct, Inflammation,     |                                                                          |            |
           Suppurative                     |                                           2                          3   |      6  2.2|
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Eye                                     |                +                                                  +     +|   5        |
      Lens, Cataract                       |                4                                                  3      |      3  3.7|
      Retina, Degeneration                 |                4                                                  3      |      4  3.5|
      Retina, Hemorrhage                   |                                                                         3|      1  3.0|
                                            __________________________________________________________________________|____________|
   Zymbal's Gland                          |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  35                                                               
NTP Experiment-Test: 05188-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                       SODIUM XYLENESULFONATE                                  Date: 09/19/95  
Route: SKIN APPLICATION                                                                                           Time: 21:28:07  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 7| 7| 4| 7| 7| 3| 5| 7| 6| 5| 7| 5| 6| 6| 7| 6| 3| 6| 7| 5| 6| 7| 6| 6|            |
                             DAY ON TEST   | 7| 3| 3| 1| 3| 3| 9| 9| 3| 1| 8| 3| 1| 5| 7| 3| 3| 9| 1| 2| 0| 3| 3| 3| 5|            |
                                           | 2| 6| 6| 2| 6| 6| 6| 1| 6| 1| 9| 6| 5| 1| 4| 6| 3| 1| 5| 8| 7| 0| 6| 4| 3|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4|      A     |
    240                                    | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|      L     |
    MG/KG                                  | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 __________________________________________________________________________________________________________________________________ 
 URINARY SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Mineralization                       |          1        1                                1        1            |     11  1.0|
      Nephropathy, Chronic                 | 2  2  1     2  2  2  1  2     2  2     2  2  1     1  2  2  1        1  2|     37  1.6|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  36                                                               
NTP Experiment-Test: 05188-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                       SODIUM XYLENESULFONATE                                  Date: 09/19/95  
Route: SKIN APPLICATION                                                                                           Time: 21:28:07  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 5| 7| 6| 4| 5| 5| 4| 6| 4| 6| 7| 5| 7| 6| 6| 6| 7| 7| 6| 6| 7| 7| 5| 7|             
                             DAY ON TEST   | 8| 6| 3| 5| 4| 6| 5| 4| 5| 9| 8| 3| 4| 0| 3| 1| 8| 0| 3| 4| 4| 0| 1| 9| 2|             
                                           | 3| 5| 5| 8| 7| 7| 4| 1| 2| 2| 1| 5| 7| 2| 6| 6| 2| 1| 5| 5| 8| 7| 5| 5| 8|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    0 MG/KG                                | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Parasite Metazoan                    |                                  X                       X               |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic Active         |                                                                          |             
      Ulcer                                |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic Active         |                   4                                                      |             
      Necrosis                             |                   4                                                      |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Basophilic Focus                     |                         X        X                                       |             
      Clear Cell Focus                     |       X                                               X                  |             
      Degeneration, Cystic                 |       1  2              1           2  2        2  1     2     2        2|             
      Hematopoietic Cell Proliferation     |                                                             2            |             
      Hepatodiaphragmatic Nodule           |                                                                          |             
      Inflammation, Chronic                | 1           1  1     1  1                 1        1  1              2   |             
      Necrosis                             | 1  1           2  3                                1                     |             
      Bile Duct, Hyperplasia               | 1  2  1  2  1  2        2  1  1  2  2  2  1  3  3  1  2  2     3  2  1  1|             
      Hepatocyte, Hyperplasia              |                                                                          |             
      Hepatocyte, Vacuolization Cytoplasmic|                                  2        1  3     2  1  3        2  2  3|             
      Hepatocyte, Centrilobular,           |                                                                          |             
          Degeneration, Fatty              |    4                                                                     |             
      Hepatocyte, Centrilobular, Necrosis  |                                                             3            |             
                                            __________________________________________________________________________|             
   Mesentery                               |    +     +                             +     +              +  +         |             
      Mineralization                       |          2                                                     2         |             
      Fat, Inflammation, Chronic Active    |          3                                                     3         |             
                                            __________________________________________________________________________|             
   Oral Mucosa                             |                                                                          |             
      Gingival, Inflammation, Chronic      |                                                                          |             
          Active                           |                                                                          |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Acinus, Atrophy                      |       1        2           2        2  2  1     1     1  1  4  2     2   |             
      Acinus, Hyperplasia                  |                                                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                                                          |             
      Inflammation, Chronic Active         |                                              3     3              3      |             
      Mineralization                       |                         3                                                |             
      Ulcer                                |                                              4     4              4      |             
      Epithelium, Hyperplasia              |                                              3     3     2        2     2|             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic Active         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  37                                                               
NTP Experiment-Test: 05188-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                       SODIUM XYLENESULFONATE                                  Date: 09/19/95  
Route: SKIN APPLICATION                                                                                           Time: 21:28:07  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 5| 7| 6| 4| 5| 5| 4| 6| 4| 6| 7| 5| 7| 6| 6| 6| 7| 7| 6| 6| 7| 7| 5| 7|             
                             DAY ON TEST   | 8| 6| 3| 5| 4| 6| 5| 4| 5| 9| 8| 3| 4| 0| 3| 1| 8| 0| 3| 4| 4| 0| 1| 9| 2|             
                                           | 3| 5| 5| 8| 7| 7| 4| 1| 2| 2| 1| 5| 7| 2| 6| 6| 2| 1| 5| 5| 8| 7| 5| 5| 8|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    0 MG/KG                                | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
                                           |                                                                          |             
      Mineralization                       |          3              3                                3              3|             
      Ulcer                                |                                                                          |             
      Epithelium, Erosion                  |                                                                          |             
                                            __________________________________________________________________________|             
   Tooth                                   |                                                                          |             
      Inflammation, Chronic Active         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood Vessel                            | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Mineralization                       |          3        1     4                                4              4|             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cardiomyopathy, Chronic              | 2     2  3  1     2     3  1  2  2        2           2  3  2  2  2      |             
      Inflammation, Chronic Active         |                                                                          |             
      Mineralization                       |          3        2     3                                2              3|             
      Atrium, Thrombosis                   |    4                    4                                                |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Accessory Adrenal Cortical Nodule    |                                                                          |             
      Degeneration, Fatty                  |          2              2              2  1  3  3  1  1  2  2     2  1  2|             
      Hyperplasia                          |    1                    1        2  2  1  1           2  1  1  1  1     2|             
                                            __________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |    1  1  2  1  1        2           1  1  1  1  1  1  2  2     1     2  1|             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |          4              4        2        2        2  3  4              4|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          | 4     2  2  2     2  3  3  4  4  2        2  2  4  3  2           3  4  4|             
      Mineralization                       |          1              2                                               3|             
      Pigmentation, Hematoidin             |                                                                          |             
      Pars Distalis, Cyst                  |             1                                         1  2        2  3   |             
      Pars Distalis, Hyperplasia           |                                  2  2     2     1     2     2  2         |             
      Pars Distalis, Pigmentation,         |                                                                          |             
          Hemosiderin                      |       2  2  1        1  1  2  1           2  2  2                 1  2  1|             
      Pars Intermedia, Cyst                |                                     1                 2                  |             
      Pars Nervosa, Cyst                   |             3                                                            |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      C-Cell, Hyperplasia                  |          1                                                              1|             
      Follicle, Cyst                       |                                                       2                  |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Peritoneum                              |    +                                         +              +            |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  38                                                               
NTP Experiment-Test: 05188-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                       SODIUM XYLENESULFONATE                                  Date: 09/19/95  
Route: SKIN APPLICATION                                                                                           Time: 21:28:07  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 5| 7| 6| 4| 5| 5| 4| 6| 4| 6| 7| 5| 7| 6| 6| 6| 7| 7| 6| 6| 7| 7| 5| 7|             
                             DAY ON TEST   | 8| 6| 3| 5| 4| 6| 5| 4| 5| 9| 8| 3| 4| 0| 3| 1| 8| 0| 3| 4| 4| 0| 1| 9| 2|             
                                           | 3| 5| 5| 8| 7| 7| 4| 1| 2| 2| 1| 5| 7| 2| 6| 6| 2| 1| 5| 5| 8| 7| 5| 5| 8|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    0 MG/KG                                | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
      Atrophy                              |       4  3     3        3        3     4  2  4     4     4  4  4  4     4|             
      Mineralization                       |          3                                                               |             
                                            __________________________________________________________________________|             
   Preputial Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                   2                                                      |             
      Inflammation, Chronic Active         |    2  1  2  1  2  1  2  2  2  1  1  2  2  2  2  2  4  2  3  2  2  2  2  2|             
      Duct, Cyst                           |                                                                          |             
                                            __________________________________________________________________________|             
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic Active         | 3  1  2  4     2  2  3  3  3  2  1  1  1  3  3  3  4  2  2  2  2  3  2  2|             
      Mineralization                       |                                                                         2|             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |       3                                                  3               |             
      Inflammation, Chronic Active         |                                              2                           |             
      Mineralization                       |                                                                         2|             
                                            __________________________________________________________________________|             
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Artery, Inflammation, Chronic        |                         1                 2           2  2               |             
      Germinal Epithelium, Atrophy         |          3     3        3     1              4  1  4  1  4              4|             
      Interstitial Cell, Hyperplasia       | 2  1     1  1  1                                1  1  1  1        1     1|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |          4     4  4     4           4  4        4  3     4  4  4         |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +     +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +   |             
      Mediastinal, Ectasia                 |                                                             2            |             
      Mediastinal, Pigmentation,           |                                                                          |             
          Hemosiderin                      | 1  2        1  1     2  1  2  1  1  1  2  2     1  1  2  2  2     2  2   |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Ectasia                              |                   4                                                      |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrosis                             |          3                                            3                  |             
      Hematopoietic Cell Proliferation     |    3              3     3                          2     3  3            |             
      Pigmentation, Hemosiderin            |                                                                          |             
      Lymphoid Follicle, Depletion Cellular|                                                                          |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Cystic                  | 2  1  2  3     1  1  2  4  3  2  2        2  2  2  2  2  2  2  2  3  2  4|             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Sebaceous Gland, Skin, Site of       |                                                                          |             
          Application, Hyperplasia         |             2                                                            |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  39                                                               
NTP Experiment-Test: 05188-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                       SODIUM XYLENESULFONATE                                  Date: 09/19/95  
Route: SKIN APPLICATION                                                                                           Time: 21:28:07  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 5| 7| 6| 4| 5| 5| 4| 6| 4| 6| 7| 5| 7| 6| 6| 6| 7| 7| 6| 6| 7| 7| 5| 7|             
                             DAY ON TEST   | 8| 6| 3| 5| 4| 6| 5| 4| 5| 9| 8| 3| 4| 0| 3| 1| 8| 0| 3| 4| 4| 0| 1| 9| 2|             
                                           | 3| 5| 5| 8| 7| 7| 4| 1| 2| 2| 1| 5| 7| 2| 6| 6| 2| 1| 5| 5| 8| 7| 5| 5| 8|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    0 MG/KG                                | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM - cont             |                                                                          |             
                                           |                                                                          |             
      Fibrous Osteodystrophy               |          3              3                                4              4|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hydrocephalus                        |                      3     3                                4     3  2  2|             
      Mineralization                       |                                                             2            |             
      Necrosis                             |                                              4                           |             
                                            __________________________________________________________________________|             
   Peripheral Nerve                        |                                           +                              |             
                                            __________________________________________________________________________|             
   Spinal Cord                             |                                           +                              |             
      Axon, Degeneration                   |                                           1                              |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Congestion, Acute                    | 4                             4                                   4  4   |             
      Inflammation, Chronic Active         |                               1  1        1                              |             
      Inflammation, Granulomatous          |                                                                          |             
      Mineralization                       |                         3                                2              3|             
      Alveolar Epithelium, Hyperplasia     |                                                                          |             
      Alveolus, Hemorrhage, Acute          |                                                 3                        |             
      Alveolus, Infiltration Cellular,     |                                                                          |             
           Histiocyte                      |       1        1        1     1        1  1           1  2           2   |             
      Interstitium, Inflammation, Chronic  |                                                                          |             
          Active                           |                                                          2               |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic Active         |                                                 3     2                  |             
      Polyp Inflammatory                   |                                        3                                 |             
      Nasolacrimal Duct, Inflammation,     |                                                                          |             
           Suppurative                     |       2     2                                      2                     |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                         +                                                |             
      Anterior Chamber, Hemorrhage, Acute  |                                                                          |             
      Cornea, Inflammation, Suppurative    |                                                                          |             
      Lens, Cataract                       |                         3                                                |             
      Retina, Degeneration                 |                         4                                                |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                                                                          |             
      Inflammation, Chronic                |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Mineralization                       |                   1  1                                                   |             
      Nephropathy, Chronic                 | 2  2  3  4  2  2  1  3  4  2  2  3  2  3  3  2  3  4  3  4  2  3  3  3  4|             
      Cortex, Cyst                         |                                  2                       2              3|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  40                                                               
NTP Experiment-Test: 05188-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                       SODIUM XYLENESULFONATE                                  Date: 09/19/95  
Route: SKIN APPLICATION                                                                                           Time: 21:28:07  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 5| 7| 6| 4| 5| 5| 4| 6| 4| 6| 7| 5| 7| 6| 6| 6| 7| 7| 6| 6| 7| 7| 5| 7|             
                             DAY ON TEST   | 8| 6| 3| 5| 4| 6| 5| 4| 5| 9| 8| 3| 4| 0| 3| 1| 8| 0| 3| 4| 4| 0| 1| 9| 2|             
                                           | 3| 5| 5| 8| 7| 7| 4| 1| 2| 2| 1| 5| 7| 2| 6| 6| 2| 1| 5| 5| 8| 7| 5| 5| 8|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    0 MG/KG                                | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic Active         |                                                                          |             
      Mineralization                       |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  41                                                               
NTP Experiment-Test: 05188-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                       SODIUM XYLENESULFONATE                                  Date: 09/19/95  
Route: SKIN APPLICATION                                                                                           Time: 21:28:07  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 6| 7| 5| 7| 5| 7| 6| 4| 6| 6| 6| 5| 5| 5| 7| 7| 6| 5| 7| 6| 7| 6| 5| 7|            |
                             DAY ON TEST   | 1| 5| 3| 4| 0| 6| 2| 7| 9| 1| 1| 1| 2| 9| 8| 3| 2| 3| 3| 3| 8| 1| 8| 5| 3|            |
                                           | 2| 0| 5| 6| 8| 0| 4| 2| 9| 6| 8| 7| 7| 0| 2| 5| 8| 9| 4| 5| 7| 3| 7| 7| 5|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      A     |
    0 MG/KG                                | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Parasite Metazoan                    |                X                                               X         |      4     |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inflammation, Chronic Active         |                                                             2            |      1  2.0|
      Ulcer                                |                                                             4            |      1  4.0|
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inflammation, Chronic Active         |                                                                          |      1  4.0|
      Necrosis                             |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Basophilic Focus                     |                                           X                              |      3     |
      Clear Cell Focus                     |                                                          X               |      3     |
      Degeneration, Cystic                 |                   2                          1                           |     12  1.7|
      Hematopoietic Cell Proliferation     |                                                                          |      1  2.0|
      Hepatodiaphragmatic Nodule           |                               X  X  X     X  X     X                     |      6     |
      Inflammation, Chronic                |    2  1  2              2        2        1  1  1     1  1        1      |     20  1.3|
      Necrosis                             | 2           3                    2                                       |      8  1.9|
      Bile Duct, Hyperplasia               |    2  2  2  3     1  1  1  3  1     1  2  2  2  1  1  2  1  3     1  1  2|     43  1.7|
      Hepatocyte, Hyperplasia              |                                                             3            |      1  3.0|
      Hepatocyte, Vacuolization Cytoplasmic|                3  3     3        2  3           1  1     1     4  2  1  2|     21  2.1|
      Hepatocyte, Centrilobular,           |                                                                          |            |
          Degeneration, Fatty              | 4                                                                        |      2  4.0|
      Hepatocyte, Centrilobular, Necrosis  |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Mesentery                               |                +                                            +            |   8        |
      Mineralization                       |                1                                                         |      3  1.7|
      Fat, Inflammation, Chronic Active    |                3                                            3            |      4  3.0|
                                            __________________________________________________________________________|____________|
   Oral Mucosa                             | +        +                                                               |   2        |
      Gingival, Inflammation, Chronic      |                                                                          |            |
          Active                           | 3                                                                        |      1  3.0|
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Acinus, Atrophy                      | 1  2  1  1        1     1  1  1        1  1              1  1     2      |     25  1.4|
      Acinus, Hyperplasia                  |                      2                                               2  2|      3  2.0|
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cyst                                 |                   4                                                      |      1  4.0|
      Inflammation, Chronic Active         |             3  3  2        3  3  2     2                    3     4      |     12  2.8|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  42                                                               
NTP Experiment-Test: 05188-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                       SODIUM XYLENESULFONATE                                  Date: 09/19/95  
Route: SKIN APPLICATION                                                                                           Time: 21:28:07  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 6| 7| 5| 7| 5| 7| 6| 4| 6| 6| 6| 5| 5| 5| 7| 7| 6| 5| 7| 6| 7| 6| 5| 7|            |
                             DAY ON TEST   | 1| 5| 3| 4| 0| 6| 2| 7| 9| 1| 1| 1| 2| 9| 8| 3| 2| 3| 3| 3| 8| 1| 8| 5| 3|            |
                                           | 2| 0| 5| 6| 8| 0| 4| 2| 9| 6| 8| 7| 7| 0| 2| 5| 8| 9| 4| 5| 7| 3| 7| 7| 5|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      A     |
    0 MG/KG                                | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
                                           |                                                                          |            |
      Mineralization                       |                                                                          |      1  3.0|
      Ulcer                                |             4              4           4                    4     4      |      8  4.0|
      Epithelium, Hyperplasia              |             3  4  3  2     2  3  3     3     2              3  4  3      |     17  2.8|
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inflammation, Chronic Active         |                            2                 2                    2      |      3  2.0|
      Mineralization                       |    3              2  3                       2                    2      |      9  2.7|
      Ulcer                                |                            4                 4                           |      2  4.0|
      Epithelium, Erosion                  |                            2                                             |      1  2.0|
                                            __________________________________________________________________________|____________|
   Tooth                                   |                   +                                                      |   1        |
      Inflammation, Chronic Active         |                   3                                                      |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood Vessel                            | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Mineralization                       |    4              2  4                                                   |      8  3.3|
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cardiomyopathy, Chronic              |    3  2  2     2  2  3  2                 2  2  2        2  1     2     2|     29  2.1|
      Inflammation, Chronic Active         |                                                                1         |      1  1.0|
      Mineralization                       |    2                 3                                                   |      7  2.6|
      Atrium, Thrombosis                   | 4                    4                                                   |      4  4.0|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Accessory Adrenal Cortical Nodule    |                   2                                                      |      1  2.0|
      Degeneration, Fatty                  | 2  1  1  2  3  3  3  1  1  1  3  2  2  1     3  2  1     1  2     2     2|     34  1.9|
      Hyperplasia                          |    2     2     2  2     2     2  1  1  1     1  2     2                 3|     25  1.6|
                                            __________________________________________________________________________|____________|
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia                          | 1     1     2  2  1     1                 1  1  2           1  2  1     2|     30  1.3|
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  M  M  +  +  +  +  +  +|  46        |
      Hyperplasia                          |                   4  4        4              3                 4         |     13  3.4|
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Angiectasis                          | 3  2     4  2  2  3  2  4     3  2  4  4  4  3  3  4  4     2        3  2|     38  2.9|
      Mineralization                       |                      2                          1                        |      5  1.8|
      Pigmentation, Hematoidin             |                2                                                     2   |      2  2.0|
      Pars Distalis, Cyst                  |                3        2  2                                             |      8  2.0|
      Pars Distalis, Hyperplasia           |    2  2                    1  2                                2         |     12  1.8|
      Pars Distalis, Pigmentation,         |                                                                          |            |
          Hemosiderin                      | 2  2  2  1  2  2  1  1  2     2  1     2  2     2  1  1  3  3        2  2|     33  1.7|
      Pars Intermedia, Cyst                |                                                                          |      2  1.5|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  43                                                               
NTP Experiment-Test: 05188-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                       SODIUM XYLENESULFONATE                                  Date: 09/19/95  
Route: SKIN APPLICATION                                                                                           Time: 21:28:07  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 6| 7| 5| 7| 5| 7| 6| 4| 6| 6| 6| 5| 5| 5| 7| 7| 6| 5| 7| 6| 7| 6| 5| 7|            |
                             DAY ON TEST   | 1| 5| 3| 4| 0| 6| 2| 7| 9| 1| 1| 1| 2| 9| 8| 3| 2| 3| 3| 3| 8| 1| 8| 5| 3|            |
                                           | 2| 0| 5| 6| 8| 0| 4| 2| 9| 6| 8| 7| 7| 0| 2| 5| 8| 9| 4| 5| 7| 3| 7| 7| 5|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      A     |
    0 MG/KG                                | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 __________________________________________________________________________________________________________________________________ 
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
                                           |                                                                          |            |
      Pars Nervosa, Cyst                   |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      C-Cell, Hyperplasia                  | 2        2  2                       2                          1         |      7  1.6|
      Follicle, Cyst                       |                2                                                         |      2  2.0|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Peritoneum                              |                                                                          |   3        |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Atrophy                              | 4     4        4  4  4           2  2        4           3     4  4      |     25  3.6|
      Mineralization                       |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Preputial Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia                          |                                                                          |      1  2.0|
      Inflammation, Chronic Active         | 1  2  2  2  2  2  2  2  2        2  1  2  1  2  2  2  1  2  1  2  2  2  2|     47  1.9|
      Duct, Cyst                           |                3                                                         |      1  3.0|
                                            __________________________________________________________________________|____________|
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inflammation, Chronic Active         | 2  2  3  3  3  4  3  4  3  2  3  3  2  3  3  3  3  3  3  1  3  2  3  3  3|     49  2.6|
      Mineralization                       |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Atrophy                              |                   3                                                      |      3  3.0|
      Inflammation, Chronic Active         |                      4                                                   |      2  3.0|
      Mineralization                       |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Artery, Inflammation, Chronic        |                   2  2                       3  2  1                    2|     10  1.9|
      Germinal Epithelium, Atrophy         | 3              4  4  4           2  2     1  4  1  1                     |     20  2.7|
      Interstitial Cell, Hyperplasia       | 1        2  1  1     1     1                          1     1           1|     20  1.1|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia                          | 4     3     4  4  4  4     4        4        4           2  4  4  3     3|     25  3.8|
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +  +        +  +        +  +  +  +  +  +  +  +  +     +  +  +  +     +  +|  41        |
      Mediastinal, Ectasia                 |                                                                          |      1  2.0|
      Mediastinal, Pigmentation,           |                                                                          |            |
          Hemosiderin                      | 1  1        3  1        1  1  2  1  1  2  2  2  1     1  1     1     1  2|     37  1.5|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Ectasia                              |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  44                                                               
NTP Experiment-Test: 05188-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                       SODIUM XYLENESULFONATE                                  Date: 09/19/95  
Route: SKIN APPLICATION                                                                                           Time: 21:28:07  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 6| 7| 5| 7| 5| 7| 6| 4| 6| 6| 6| 5| 5| 5| 7| 7| 6| 5| 7| 6| 7| 6| 5| 7|            |
                             DAY ON TEST   | 1| 5| 3| 4| 0| 6| 2| 7| 9| 1| 1| 1| 2| 9| 8| 3| 2| 3| 3| 3| 8| 1| 8| 5| 3|            |
                                           | 2| 0| 5| 6| 8| 0| 4| 2| 9| 6| 8| 7| 7| 0| 2| 5| 8| 9| 4| 5| 7| 3| 7| 7| 5|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      A     |
    0 MG/KG                                | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
      Fibrosis                             |                                        3        2        3              2|      6  2.7|
      Hematopoietic Cell Proliferation     |                2  3  4              2        2                 2         |     12  2.7|
      Pigmentation, Hemosiderin            |    3                                            2              2  2      |      4  2.3|
      Lymphoid Follicle, Depletion Cellular|    3                                                                     |      1  3.0|
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  M  M  +  +  +|  46        |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia, Cystic                  | 2        1  2  2  2  4  2     4  3  4  3  4  3  4  1     1  4     4  2  3|     42  2.5|
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Sebaceous Gland, Skin, Site of       |                                                                          |            |
          Application, Hyperplasia         |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Fibrous Osteodystrophy               |                   3  4                       2                 4  3     2|     10  3.2|
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hydrocephalus                        | 2                       3        2     2  3                              |     11  2.6|
      Mineralization                       |                                                                          |      1  2.0|
      Necrosis                             |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Peripheral Nerve                        |                                                                          |   1        |
                                            __________________________________________________________________________|____________|
   Spinal Cord                             |                                                                          |   1        |
      Axon, Degeneration                   |                                                                          |      1  1.0|
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Congestion, Acute                    |    4                 3                    3        4  4              4   |     10  3.8|
      Inflammation, Chronic Active         |                                                                          |      3  1.0|
      Inflammation, Granulomatous          |                                                       2  2               |      2  2.0|
      Mineralization                       |    3              2  3  1                                                |      7  2.4|
      Alveolar Epithelium, Hyperplasia     |                               3                                3     3   |      3  3.0|
      Alveolus, Hemorrhage, Acute          |                   3  2                                                   |      3  2.7|
      Alveolus, Infiltration Cellular,     |                                                                          |            |
           Histiocyte                      | 1     1  1     1  4  3  1  1  1        1     2  1              2  1     1|     24  1.4|
      Interstitium, Inflammation, Chronic  |                                                                          |            |
          Active                           |                   4  3        1     1        3                 2         |      7  2.3|
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  45                                                               
NTP Experiment-Test: 05188-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                       SODIUM XYLENESULFONATE                                  Date: 09/19/95  
Route: SKIN APPLICATION                                                                                           Time: 21:28:07  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 6| 7| 5| 7| 5| 7| 6| 4| 6| 6| 6| 5| 5| 5| 7| 7| 6| 5| 7| 6| 7| 6| 5| 7|            |
                             DAY ON TEST   | 1| 5| 3| 4| 0| 6| 2| 7| 9| 1| 1| 1| 2| 9| 8| 3| 2| 3| 3| 3| 8| 1| 8| 5| 3|            |
                                           | 2| 0| 5| 6| 8| 0| 4| 2| 9| 6| 8| 7| 7| 0| 2| 5| 8| 9| 4| 5| 7| 3| 7| 7| 5|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      A     |
    0 MG/KG                                | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 __________________________________________________________________________________________________________________________________ 
 RESPIRATORY SYSTEM - cont                 |                                                                          |            |
                                           |                                                                          |            |
      Inflammation, Chronic Active         | 2     2                                      2                           |      5  2.2|
      Polyp Inflammatory                   |                                                                          |      1  3.0|
      Nasolacrimal Duct, Inflammation,     |                                                                          |            |
           Suppurative                     | 1                                               3                        |      5  2.0|
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Eye                                     |          +                                                           +   |   3        |
      Anterior Chamber, Hemorrhage, Acute  |          3                                                               |      1  3.0|
      Cornea, Inflammation, Suppurative    |          2                                                               |      1  2.0|
      Lens, Cataract                       |                                                                      3   |      2  3.0|
      Retina, Degeneration                 |                                                                      4   |      2  4.0|
                                            __________________________________________________________________________|____________|
   Harderian Gland                         |                                                          +               |   1        |
      Inflammation, Chronic                |                                                          2               |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Mineralization                       |    3                 3                                                   |      4  2.0|
      Nephropathy, Chronic                 | 3  4  3  3  3  3  4  4  2  1  4  3  1  2  2  3  4  3  1  3  3  4  4  2  4|     50  2.8|
      Cortex, Cyst                         |                   3  3        3              2                 2         |      8  2.5|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inflammation, Chronic Active         |                      3                                                   |      1  3.0|
      Mineralization                       |    2                                                                     |      1  2.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  46                                                               
NTP Experiment-Test: 05188-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                       SODIUM XYLENESULFONATE                                  Date: 09/19/95  
Route: SKIN APPLICATION                                                                                           Time: 21:28:07  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 6| 5| 6| 4| 5| 7| 7| 7| 6| 7| 7| 7| 6| 5| 7| 7| 1| 5| 7| 4| 7| 7| 6|             
                             DAY ON TEST   | 0| 3| 4| 4| 3| 9| 4| 0| 3| 2| 1| 3| 3| 3| 4| 6| 3| 3| 9| 1| 3| 4| 3| 3| 5|             
                                           | 9| 5| 5| 7| 1| 1| 1| 2| 5| 6| 9| 5| 5| 5| 3| 5| 5| 5| 6| 6| 2| 1| 5| 5| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    60 MG/KG                               | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +     +  +  +  +  +  +     +  +           +  +        +  +  +  +        +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +     +  +  +  +  +  +     +  +           +  +        +  +  +  +        +|             
      Parasite Metazoan                    |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +     +  +  +  +  +  +     +  +           +  +        +  +  +  +        +|             
      Parasite Metazoan                    |          X  X                                                            |             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +     +  +  +  +  +  +     +  +           +  +        +  +  +  +        +|             
      Inflammation, Chronic Active         |                                                                          |             
      Ulcer                                |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +     +  +  +  +  +  +     +  +           +  +        +  +  +  +        +|             
      Inflammation, Chronic Active         |                                                                          |             
      Ulcer                                |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +     +  +  +  +  +  +     +  +           +  +        +  +  +  +        +|             
      Inflammation, Chronic Active         |                                                                          |             
      Ulcer                                |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +     +  +  +  +  +  +     +  +           +  +        +  +  +  +        +|             
      Inflammation, Chronic Active         |                                                          3               |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +     +  +  +  +  +  +  +|             
      Degeneration, Cystic                 |                                                                          |             
      Hematopoietic Cell Proliferation     |             2                                                            |             
      Hepatodiaphragmatic Nodule           |                               X                                          |             
      Inflammation, Chronic                |          1  1                 1           1              1               |             
      Necrosis                             |                3                                                         |             
      Pigmentation, Hemosiderin            |                      2                                                   |             
      Bile Duct, Hyperplasia               |       2  2  2  2  3  3     2  2           1  2           1  2  1        2|             
      Central Vein, Thrombosis             |                   2                                                      |             
      Hepatocyte, Hyperplasia              |                                                                          |             
      Hepatocyte, Vacuolization Cytoplasmic| 4        1                                3  1           1  3            |             
      Hepatocyte, Centrilobular,           |                                                                          |             
          Degeneration, Fatty              |                      4                                                   |             
      Hepatocyte, Centrilobular, Necrosis  |             2     3                                         4            |             
                                            __________________________________________________________________________|             
   Mesentery                               |             +     +        +                                            +|             
      Mineralization                       |                                                                         3|             
      Artery, Inflammation, Chronic Active |                            3                                             |             
      Fat, Inflammation, Chronic Active    |             4                                                           3|             
                                            __________________________________________________________________________|             
   Oral Mucosa                             |                                                                          |             
      Gingival, Inflammation, Chronic      |                                                                          |             
          Active                           |                                                                          |             
                                            __________________________________________________________________________|             
   Pancreas                                | +     +  +  +  +  +  +     +  +           +  +        +  +  +  +        +|             
      Acinus, Atrophy                      |                   2        1  3              1        1  1     2         |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +     +  +  +  +  +  +     +  +           +  +        +  +  +  +        +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +     +  +  +  +  +  +     +  +           +  +        +  +  +  +        +|             
      Inflammation, Chronic Active         | 3                    2                    3                             2|             
      Ulcer                                | 3                    3                    4                             2|             
      Epithelium, Hyperplasia              | 3                    2                    3                             2|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  47                                                               
NTP Experiment-Test: 05188-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                       SODIUM XYLENESULFONATE                                  Date: 09/19/95  
Route: SKIN APPLICATION                                                                                           Time: 21:28:07  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 6| 5| 6| 4| 5| 7| 7| 7| 6| 7| 7| 7| 6| 5| 7| 7| 1| 5| 7| 4| 7| 7| 6|             
                             DAY ON TEST   | 0| 3| 4| 4| 3| 9| 4| 0| 3| 2| 1| 3| 3| 3| 4| 6| 3| 3| 9| 1| 3| 4| 3| 3| 5|             
                                           | 9| 5| 5| 7| 1| 1| 1| 2| 5| 6| 9| 5| 5| 5| 3| 5| 5| 5| 6| 6| 2| 1| 5| 5| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    60 MG/KG                               | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +     +  +  +  +  +  +     +  +           +  +        +  +  +  +        +|             
      Inflammation, Chronic Active         |                                                                         3|             
      Mineralization                       |                                                                          |             
      Necrosis                             |                2                                                         |             
      Ulcer                                |                                                                         4|             
      Epithelium, Erosion                  |                                                                         3|             
      Epithelium, Hyperplasia              |                                                                          |             
                                            __________________________________________________________________________|             
   Tongue                                  |       +                                                                  |             
      Cyst                                 |       3                                                                  |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood Vessel                            | +     +  +  +  +  +  +     +  +           +  +        +  +  +  +        +|             
                                            __________________________________________________________________________|             
   Heart                                   | +     +  +  +  +  +  +     +  +           +  +        +  +  +  +        +|             
      Cardiomyopathy, Chronic              | 2        2     2     2     2  2           2  2        1     3  2         |             
      Inflammation, Chronic Active         |                                                                          |             
      Mineralization                       |                2                                                         |             
      Atrium, Thrombosis                   |                   3  3                                      4            |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Cortex                          | +     +  +  +  +  +  +     +  +           +  +        +  +  +  +        +|             
      Degeneration, Fatty                  | 3     2     3     1           1           2              2  2           2|             
      Hyperplasia                          |                                                                         1|             
      Hypertrophy                          |                            2                                             |             
                                            __________________________________________________________________________|             
   Adrenal Medulla                         | +     +  +  +  +  +  +     +  +           +  +        +  +  +  +        +|             
      Hyperplasia                          |                   1                       2                             2|             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +     +  +  +  +  +  +     +  +           +  +        +  +  +  +        +|             
      Hyperplasia                          |                               2                                          |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +     M  +  +  +  M  +     +  +           +  +        +  +  +  +        +|             
      Hyperplasia                          |                                                                          |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +     +  +  +  +  +  +     +  +           +  +        +  +  +  +        +|             
      Angiectasis                          | 2     4  3  2        2     3  4           3  4           4  2  2         |             
      Hemorrhage                           |                                                                          |             
      Necrosis                             |                                                                          |             
      Pigmentation, Hematoidin             |                               2                                          |             
      Pars Distalis, Cyst                  |                      2                                      2  2         |             
      Pars Distalis, Hyperplasia           |                   2                                                     2|             
      Pars Distalis, Pigmentation,         |                                                                          |             
          Hemosiderin                      | 1     2  1  2        3     1  2           1              1  1  2         |             
      Pars Distalis, Thrombosis            |                                                                          |             
      Pars Intermedia, Cyst                |                                                                          |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +     +  +  +  +  +  +     +  +           +  +        +  +  +  +        +|             
      C-Cell, Hyperplasia                  |                   1  2     2                             2              2|             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  48                                                               
NTP Experiment-Test: 05188-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                       SODIUM XYLENESULFONATE                                  Date: 09/19/95  
Route: SKIN APPLICATION                                                                                           Time: 21:28:07  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 6| 5| 6| 4| 5| 7| 7| 7| 6| 7| 7| 7| 6| 5| 7| 7| 1| 5| 7| 4| 7| 7| 6|             
                             DAY ON TEST   | 0| 3| 4| 4| 3| 9| 4| 0| 3| 2| 1| 3| 3| 3| 4| 6| 3| 3| 9| 1| 3| 4| 3| 3| 5|             
                                           | 9| 5| 5| 7| 1| 1| 1| 2| 5| 6| 9| 5| 5| 5| 3| 5| 5| 5| 6| 6| 2| 1| 5| 5| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    60 MG/KG                               | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM - cont                |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Peritoneum                              |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              | +     +  +  +  +  +  +     +  +           +  +        +  +  +  +        +|             
      Atrophy                              |                   4        4              3                 4           4|             
      Inflammation, Chronic Active         |                3                                                         |             
                                            __________________________________________________________________________|             
   Preputial Gland                         | +     +  +  +  +  +  +     +  +           +  +        +  +  +  +        +|             
      Hyperplasia                          |                                                             4            |             
      Inflammation, Chronic Active         | 2     2  2        2  2     2  2           2  1        2  1  3           2|             
      Duct, Cyst                           |                                                                          |             
                                            __________________________________________________________________________|             
   Prostate                                | +     +  +  +  +  +  +     +  +           +  +        +  +  +  +        +|             
      Inflammation, Chronic Active         | 2     2  2  2  2  1  4     3  3           3  3           2  2  3        3|             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         | +     +  +  +  +  +  +     +  +           +  +        +  +  +  +        +|             
      Atrophy                              |                            3              3                 3            |             
      Inflammation, Chronic Active         |                                                                          |             
                                            __________________________________________________________________________|             
   Testes                                  | +     +  +  +  +  +  +     +  +           +  +        +  +  +  +        +|             
      Artery, Inflammation, Chronic        |       1                                                                  |             
      Germinal Epithelium, Atrophy         | 2                                                           4            |             
      Interstitial Cell, Hyperplasia       |       1     1     1  1                       1              1           2|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | M     +  +  +  +  +  +     +  +           +  +        +  +  +  +        +|             
      Hyperplasia                          |             4     4  4                                      4           4|             
                                            __________________________________________________________________________|             
   Lymph Node                              | +     +  +  +     +  +     +  +              +        +        +        +|             
      Lumbar, Hyperplasia, Lymphoid        |                                                                4         |             
      Mediastinal, Infiltration Cellular,  |                                                                          |             
           Histiocyte                      |                                                                          |             
      Mediastinal, Pigmentation,           |                                                                          |             
          Hemosiderin                      | 2     2  1  2     1  1     2  1              1        1        1         |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +     +  +  +  +  +  +     +  +           +  +        +  +  +  +        +|             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +     +  +  +  +  +  +     +  +           +  +        +  +  +  +        +|             
      Ectasia                              |                            2                                             |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +|             
      Hematopoietic Cell Proliferation     |             3     3                                         2           3|             
                                            __________________________________________________________________________|             
   Thymus                                  | +     +  +  +  M  +  +     +  +           +  M        +  +  +  +        +|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +     +  +  +  +  M  +     +  +           +  +        +  +  +  +        +|             
      Hyperplasia, Cystic                  | 2     1  2  2        3     2  2           3  2           2  2  4        1|             
      Duct, Cyst                           |                                                                          |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperkeratosis                       |          3                                                               |             
      Epidermis, Skin, Site of Application,|                                                                          |             
           Hyperplasia                     |    1                                                                     |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  49                                                               
NTP Experiment-Test: 05188-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                       SODIUM XYLENESULFONATE                                  Date: 09/19/95  
Route: SKIN APPLICATION                                                                                           Time: 21:28:07  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 6| 5| 6| 4| 5| 7| 7| 7| 6| 7| 7| 7| 6| 5| 7| 7| 1| 5| 7| 4| 7| 7| 6|             
                             DAY ON TEST   | 0| 3| 4| 4| 3| 9| 4| 0| 3| 2| 1| 3| 3| 3| 4| 6| 3| 3| 9| 1| 3| 4| 3| 3| 5|             
                                           | 9| 5| 5| 7| 1| 1| 1| 2| 5| 6| 9| 5| 5| 5| 3| 5| 5| 5| 6| 6| 2| 1| 5| 5| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    60 MG/KG                               | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Sebaceous Gland, Skin, Site of       |                                                                          |             
          Application, Hyperplasia         |                                                                          |             
      Skin, Site of Application,           |                                                                          |             
          Inflammation, Chronic Active     |    1                                                                     |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | M     +  +  +  +  +  +     +  +           +  +        +  +  +  +        +|             
      Fibrous Osteodystrophy               |                                                                          |             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |                   +                                                     +|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +     +  +  +  +  +  +     +  +           +  +        +  +  +  +        +|             
      Hemorrhage, Acute                    |                                                                          |             
      Hydrocephalus                        |                               4              2           4     2         |             
                                            __________________________________________________________________________|             
   Peripheral Nerve                        |                                              +                           |             
                                            __________________________________________________________________________|             
   Spinal Cord                             |                                              +                           |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +     +  +  +  +  +  +     +  +           +  +        +  +  +  +        +|             
      Congestion, Acute                    |       4  4                 4  4              3        4                  |             
      Inflammation, Chronic Active         |                                                                          |             
      Alveolar Epithelium, Hyperplasia     |             1                                2                           |             
      Alveolus, Hemorrhage, Acute          |                                                                          |             
      Alveolus, Infiltration Cellular,     |                                                                          |             
           Histiocyte                      |       1     1        1        1              1           1               |             
                                            __________________________________________________________________________|             
   Nose                                    | M     +  +  +  +  +  +     +  +           +  +        +  +  +  +        +|             
      Inflammation, Chronic Active         |                      2                    2                 3            |             
      Thrombosis                           |                                                                          |             
      Nasolacrimal Duct, Inflammation,     |                                                                          |             
           Suppurative                     |                                                                1         |             
                                            __________________________________________________________________________|             
   Trachea                                 | +     +  +  +  +  +  +     +  +           +  +        +  +  +  +        +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                                                          +               |             
      Lens, Cataract                       |                                                                          |             
      Retina, Degeneration                 |                                                          4               |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                                                       +                  |             
      Inflammation, Chronic                |                                                       2                  |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +     +  +  +  +  +  +     +  +           +  +        +  +  +  +        +|             
      Mineralization                       |                1                                                         |             
      Nephropathy, Chronic                 | 3     3  2  2     2  3     3  2           3  2        1  2  3  3        2|             
      Cortex, Cyst                         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  50                                                               
NTP Experiment-Test: 05188-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                       SODIUM XYLENESULFONATE                                  Date: 09/19/95  
Route: SKIN APPLICATION                                                                                           Time: 21:28:07  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 6| 5| 6| 4| 5| 7| 7| 7| 6| 7| 7| 7| 6| 5| 7| 7| 1| 5| 7| 4| 7| 7| 6|             
                             DAY ON TEST   | 0| 3| 4| 4| 3| 9| 4| 0| 3| 2| 1| 3| 3| 3| 4| 6| 3| 3| 9| 1| 3| 4| 3| 3| 5|             
                                           | 9| 5| 5| 7| 1| 1| 1| 2| 5| 6| 9| 5| 5| 5| 3| 5| 5| 5| 6| 6| 2| 1| 5| 5| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    60 MG/KG                               | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +     +  +  +  +  +  +     +  +           +  +        +  +  +  +        +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  51                                                               
NTP Experiment-Test: 05188-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                       SODIUM XYLENESULFONATE                                  Date: 09/19/95  
Route: SKIN APPLICATION                                                                                           Time: 21:28:07  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 6| 7| 7| 6| 7| 6| 6| 6| 3| 5| 6| 7| 7| 5| 7| 6| 7| 7| 3| 6| 6| 3| 7|            |
                             DAY ON TEST   | 3| 3| 3| 3| 1| 5| 3| 4| 0| 2| 6| 2| 0| 3| 0| 4| 3| 0| 3| 3| 9| 7| 0| 4| 0|            |
                                           | 5| 5| 1| 5| 0| 8| 5| 5| 3| 3| 2| 7| 9| 5| 2| 0| 5| 1| 5| 5| 3| 4| 3| 9| 2|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1|      A     |
    60 MG/KG                               | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               |       +     +  +     +  +  +  +  +  +     +  +     +        +  +  +  +  +|  33        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  |       +     +  +     +  +  +  +  +  +     +  +     +        +  +  +  +  +|  33        |
      Parasite Metazoan                    |                      X                                                   |      1     |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 |       +     +  +     +  +  +  +  +  +     +  +     +        +  +  +  +  +|  33        |
      Parasite Metazoan                    |                                                                          |      2     |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  |       +     +  +     +  +  +  +  +  +     +  +     +        +  +  +  +  +|  33        |
      Inflammation, Chronic Active         |                            3                                             |      1  3.0|
      Ulcer                                |                            4                                             |      1  4.0|
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               |       +     +  +     +  +  +  +  +  +     +  +     +        +  +  +  +  +|  33        |
      Inflammation, Chronic Active         |                                                                2         |      1  2.0|
      Ulcer                                |                                                                4         |      1  4.0|
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                |       +     +  +     +  +  +  +  +  +     +  +     +        +  +  +  +  +|  33        |
      Inflammation, Chronic Active         |                                                                4         |      1  4.0|
      Ulcer                                |                                                                4         |      1  4.0|
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  |       +     +  +     +  +  +  +  +  +     +  +     +        +  +  +  +  +|  33        |
      Inflammation, Chronic Active         |                            3                                             |      2  3.0|
                                            __________________________________________________________________________|____________|
   Liver                                   |       +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +|  45        |
      Degeneration, Cystic                 |       4     3        1  2                                                |      4  2.5|
      Hematopoietic Cell Proliferation     |                                                                          |      1  2.0|
      Hepatodiaphragmatic Nodule           |       X                                                                  |      2     |
      Inflammation, Chronic                |                               1              1              1     1      |      9  1.0|
      Necrosis                             |       3                                            2           2         |      4  2.5|
      Pigmentation, Hemosiderin            |                                                                          |      1  2.0|
      Bile Duct, Hyperplasia               |       3     2  1     1  2  2     2  2        1     3        2  1  1  1  1|     29  1.8|
      Central Vein, Thrombosis             |                                                                          |      1  2.0|
      Hepatocyte, Hyperplasia              |                                                    4                     |      1  4.0|
      Hepatocyte, Vacuolization Cytoplasmic|                1     2  3           2                                   1|     11  2.0|
      Hepatocyte, Centrilobular,           |                                                                          |            |
          Degeneration, Fatty              |       4                                            4           4         |      4  4.0|
      Hepatocyte, Centrilobular, Necrosis  |                                                                          |      3  3.0|
                                            __________________________________________________________________________|____________|
   Mesentery                               |                                  +  +                          +         |   7        |
      Mineralization                       |                                                                          |      1  3.0|
      Artery, Inflammation, Chronic Active |                                                                          |      1  3.0|
      Fat, Inflammation, Chronic Active    |                                     2                                    |      3  3.0|
                                            __________________________________________________________________________|____________|
   Oral Mucosa                             |                                                                +         |   1        |
      Gingival, Inflammation, Chronic      |                                                                          |            |
          Active                           |                                                                2         |      1  2.0|
                                            __________________________________________________________________________|____________|
   Pancreas                                |       +     +  +     +  +  +  +  +  +     +  +     +        +  +  +  +  +|  33        |
      Acinus, Atrophy                      |       2                 1  1              3                 1  3         |     13  1.7|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  52                                                               
NTP Experiment-Test: 05188-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                       SODIUM XYLENESULFONATE                                  Date: 09/19/95  
Route: SKIN APPLICATION                                                                                           Time: 21:28:07  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 6| 7| 7| 6| 7| 6| 6| 6| 3| 5| 6| 7| 7| 5| 7| 6| 7| 7| 3| 6| 6| 3| 7|            |
                             DAY ON TEST   | 3| 3| 3| 3| 1| 5| 3| 4| 0| 2| 6| 2| 0| 3| 0| 4| 3| 0| 3| 3| 9| 7| 0| 4| 0|            |
                                           | 5| 5| 1| 5| 0| 8| 5| 5| 3| 3| 2| 7| 9| 5| 2| 0| 5| 1| 5| 5| 3| 4| 3| 9| 2|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1|      A     |
    60 MG/KG                               | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Salivary Glands                         |       +     +  +     +  +  +  +  +  +     +  +     +        +  +  +  +  +|  33        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    |       +     +  +     +  +  +  +  +  +     +  +     +        +  +  +  +  +|  33        |
      Inflammation, Chronic Active         |                      3  3  2        3              3           3        3|     11  2.7|
      Ulcer                                |                      4  3           4              4           4        4|     10  3.5|
      Epithelium, Hyperplasia              |                      4  2  3        3     4        3                    3|     11  2.9|
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      |       +     +  +     +  +  +  +  +  +     +  +     +        +  +  +  +  +|  33        |
      Inflammation, Chronic Active         |       2                    3                       3                     |      4  2.8|
      Mineralization                       |                                           2                              |      1  2.0|
      Necrosis                             |                                                                          |      1  2.0|
      Ulcer                                |       4                    4                                             |      3  4.0|
      Epithelium, Erosion                  |       4                 2                          4                     |      4  3.3|
      Epithelium, Hyperplasia              |                                                                         2|      1  2.0|
                                            __________________________________________________________________________|____________|
   Tongue                                  |                                                                          |   1        |
      Cyst                                 |                                                                          |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood Vessel                            |       +     +  +     +  +  +  +  +  +     +  +     +        +  +  +  +  +|  33        |
                                            __________________________________________________________________________|____________|
   Heart                                   |       +     +  +     +  +  +  +  +  +     +  +     +        +  +  +  +  +|  33        |
      Cardiomyopathy, Chronic              |       2     2  2     2                    2                 1  2  2  1  2|     21  1.9|
      Inflammation, Chronic Active         |                            2                                             |      1  2.0|
      Mineralization                       |                                                                          |      1  2.0|
      Atrium, Thrombosis                   |       4                 4                                      4         |      6  3.7|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Cortex                          |       +     +  +     +  +  +  +  +  +     +  +     +        +  +  +  +  +|  33        |
      Degeneration, Fatty                  |       2     1  1     2  2  1     1  3     2  1     3           2  1     2|     23  1.8|
      Hyperplasia                          |             2  1                          1                    3        2|      6  1.7|
      Hypertrophy                          |                            1                                             |      2  1.5|
                                            __________________________________________________________________________|____________|
   Adrenal Medulla                         |       +     +  +     +  +  +  +  +  +     +  +     +        +  +  +  +  +|  33        |
      Hyperplasia                          |       1        1        2  1              2                    2        2|     10  1.6|
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      |       +     +  +     +  +  +  +  +  +     +  +     +        +  +  +  +  +|  33        |
      Hyperplasia                          |                                                                2         |      2  2.0|
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       |       +     +  +     +  +  +  M  +  +     +  +     +        +  +  +  +  M|  29        |
      Hyperplasia                          |                      2              2     3                              |      3  2.3|
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         |       +     +  +     +  +  +  +  +  +     +  +     +        +  +  +  +  +|  33        |
      Angiectasis                          |             2  4     2  3  4        3     1  4     1        4  2  4  4  4|     26  3.0|
      Hemorrhage                           |                            4                                             |      1  4.0|
      Necrosis                             |                                                    2                     |      1  2.0|
      Pigmentation, Hematoidin             |                                                                          |      1  2.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  53                                                               
NTP Experiment-Test: 05188-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                       SODIUM XYLENESULFONATE                                  Date: 09/19/95  
Route: SKIN APPLICATION                                                                                           Time: 21:28:07  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 6| 7| 7| 6| 7| 6| 6| 6| 3| 5| 6| 7| 7| 5| 7| 6| 7| 7| 3| 6| 6| 3| 7|            |
                             DAY ON TEST   | 3| 3| 3| 3| 1| 5| 3| 4| 0| 2| 6| 2| 0| 3| 0| 4| 3| 0| 3| 3| 9| 7| 0| 4| 0|            |
                                           | 5| 5| 1| 5| 0| 8| 5| 5| 3| 3| 2| 7| 9| 5| 2| 0| 5| 1| 5| 5| 3| 4| 3| 9| 2|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1|      A     |
    60 MG/KG                               | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 __________________________________________________________________________________________________________________________________ 
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
                                           |                                                                          |            |
      Pars Distalis, Cyst                  |                         2                                      2         |      5  2.0|
      Pars Distalis, Hyperplasia           |       2                          2                 2                     |      5  2.0|
      Pars Distalis, Pigmentation,         |                                                                          |            |
          Hemosiderin                      |             1  1        1                 2  1              2     2  1  2|     20  1.5|
      Pars Distalis, Thrombosis            |                            4                                             |      1  4.0|
      Pars Intermedia, Cyst                |       2                                                        2         |      2  2.0|
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           |       +     +  +     +  +  +  +  +  +     +  +     +        +  +  +  +  +|  33        |
      C-Cell, Hyperplasia                  |       1     1                                      2                     |      8  1.6|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Peritoneum                              |                                                                +         |   1        |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Epididymis                              |       +     +  +     +  +  +  +  +  +     +  +     +        +  +  +  +  +|  33        |
      Atrophy                              |             4                       4     4                    4        2|     10  3.7|
      Inflammation, Chronic Active         |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Preputial Gland                         |       +     +  +     +  +  +  +  +  +     +  +     +        +  +  +  +  +|  33        |
      Hyperplasia                          |                                                                          |      1  4.0|
      Inflammation, Chronic Active         |       2     2           1  3  2  2  3     3        1        1  2  1  2  2|     27  1.9|
      Duct, Cyst                           |                2                                                         |      1  2.0|
                                            __________________________________________________________________________|____________|
   Prostate                                |       +     +  +     +  +  +  +  +  +     +  +     +        +  +  +  +  +|  33        |
      Inflammation, Chronic Active         |       2     3  2     2  3  3  1  2  3     4  1     2        3  3  2  4  3|     32  2.5|
                                            __________________________________________________________________________|____________|
   Seminal Vesicle                         |       +     +  +     +  +  +  +  +  +     +  +     +        +  +  +  +  +|  33        |
      Atrophy                              |             3                       3     4                             3|      7  3.1|
      Inflammation, Chronic Active         |                                           3                              |      1  3.0|
                                            __________________________________________________________________________|____________|
   Testes                                  |       +     +  +     +  +  +  +  +  +     +  +     +        +  +  +  +  +|  33        |
      Artery, Inflammation, Chronic        |                                           2                              |      2  1.5|
      Germinal Epithelium, Atrophy         |             4                             4                    4        2|      6  3.3|
      Interstitial Cell, Hyperplasia       |             1        1              1                       1     1     1|     13  1.1|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             |       +     +  +     +  +  +  +  +  +     +  +     +        +  +  +  +  +|  32        |
      Hyperplasia                          |       3     3           4  4     4        4        4           4         |     13  3.8|
                                            __________________________________________________________________________|____________|
   Lymph Node                              |       +     +  +        +  +  +  +  +     +  +                 +  +     +|  25        |
      Lumbar, Hyperplasia, Lymphoid        |                                                                          |      1  4.0|
      Mediastinal, Infiltration Cellular,  |                                                                          |            |
           Histiocyte                      |                                                                4         |      1  4.0|
      Mediastinal, Pigmentation,           |                                                                          |            |
          Hemosiderin                      |       1     1  1        1  1  2     1     1  2                 3  2     1|     23  1.4|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  54                                                               
NTP Experiment-Test: 05188-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                       SODIUM XYLENESULFONATE                                  Date: 09/19/95  
Route: SKIN APPLICATION                                                                                           Time: 21:28:07  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 6| 7| 7| 6| 7| 6| 6| 6| 3| 5| 6| 7| 7| 5| 7| 6| 7| 7| 3| 6| 6| 3| 7|            |
                             DAY ON TEST   | 3| 3| 3| 3| 1| 5| 3| 4| 0| 2| 6| 2| 0| 3| 0| 4| 3| 0| 3| 3| 9| 7| 0| 4| 0|            |
                                           | 5| 5| 1| 5| 0| 8| 5| 5| 3| 3| 2| 7| 9| 5| 2| 0| 5| 1| 5| 5| 3| 4| 3| 9| 2|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1|      A     |
    60 MG/KG                               | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  |       +     +  +     +  +  +  +  +  +     +  +     +        +  +  +  +  +|  33        |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  |       +     +  +     +  +  +  +  +  +     +  +     +        +  +  +  +  +|  33        |
      Ectasia                              |                                                                4  2      |      3  2.7|
                                            __________________________________________________________________________|____________|
   Spleen                                  |       +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +|  46        |
      Hematopoietic Cell Proliferation     |                                           2                    3         |      6  2.7|
                                            __________________________________________________________________________|____________|
   Thymus                                  |       +     +  +     +  +  +  +  +  +     +  +     +        +  +  +  +  +|  31        |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           |       +     +  +     +  +  +  +  +  +     +  +     +        +  +  +  +  +|  32        |
      Hyperplasia, Cystic                  |       1        2     2  2  1        1     1  2     1        3  2  2     4|     26  2.0|
      Duct, Cyst                           |                                                                         4|      1  4.0|
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperkeratosis                       |                                                                          |      1  3.0|
      Epidermis, Skin, Site of Application,|                                                                          |            |
           Hyperplasia                     |                                                                          |      1  1.0|
      Sebaceous Gland, Skin, Site of       |                                                                          |            |
          Application, Hyperplasia         |                                                                   1      |      1  1.0|
      Skin, Site of Application,           |                                                                          |            |
          Inflammation, Chronic Active     |                                                                          |      1  1.0|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    |       +     +  +     +  +  +  +  +  +     +  +     +        +  +  +  +  +|  32        |
      Fibrous Osteodystrophy               |                                           3                              |      1  3.0|
                                            __________________________________________________________________________|____________|
   Skeletal Muscle                         |             +                                                            |   3        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   |       +     +  +     +  +  +  +  +  +     +  +     +        +  +  +  +  +|  33        |
      Hemorrhage, Acute                    |                                                    4                     |      1  4.0|
      Hydrocephalus                        |                3     3              3        3              2     3  3  3|     12  2.9|
                                            __________________________________________________________________________|____________|
   Peripheral Nerve                        |                                                                          |   1        |
                                            __________________________________________________________________________|____________|
   Spinal Cord                             |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    |       +     +  +     +  +  +  +  +  +     +  +     +        +  +  +  +  +|  33        |
      Congestion, Acute                    |                      4                       3                    4      |      9  3.8|
      Inflammation, Chronic Active         |                               1                                          |      1  1.0|
      Alveolar Epithelium, Hyperplasia     |                                                                          |      2  1.5|
      Alveolus, Hemorrhage, Acute          |                                              2                           |      1  2.0|
      Alveolus, Infiltration Cellular,     |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  55                                                               
NTP Experiment-Test: 05188-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                       SODIUM XYLENESULFONATE                                  Date: 09/19/95  
Route: SKIN APPLICATION                                                                                           Time: 21:28:07  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 6| 7| 7| 6| 7| 6| 6| 6| 3| 5| 6| 7| 7| 5| 7| 6| 7| 7| 3| 6| 6| 3| 7|            |
                             DAY ON TEST   | 3| 3| 3| 3| 1| 5| 3| 4| 0| 2| 6| 2| 0| 3| 0| 4| 3| 0| 3| 3| 9| 7| 0| 4| 0|            |
                                           | 5| 5| 1| 5| 0| 8| 5| 5| 3| 3| 2| 7| 9| 5| 2| 0| 5| 1| 5| 5| 3| 4| 3| 9| 2|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1|      A     |
    60 MG/KG                               | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 __________________________________________________________________________________________________________________________________ 
 RESPIRATORY SYSTEM - cont                 |                                                                          |            |
                                           |                                                                          |            |
           Histiocyte                      |                1           1  1     1                                    |     10  1.0|
                                            __________________________________________________________________________|____________|
   Nose                                    |       +     +  +     +  +  +  +  +  +     +  +     +        +  +  +  +  +|  32        |
      Inflammation, Chronic Active         |                2        1  2  3                                3         |      8  2.3|
      Thrombosis                           |                                                                2         |      1  2.0|
      Nasolacrimal Duct, Inflammation,     |                                                                          |            |
           Suppurative                     |                         3                          1                     |      3  1.7|
                                            __________________________________________________________________________|____________|
   Trachea                                 |       +     +  +     +  +  +  +  +  +     +  +     +        +  +  +  +  +|  33        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Eye                                     |                      +                                                   |   2        |
      Lens, Cataract                       |                      3                                                   |      1  3.0|
      Retina, Degeneration                 |                      4                                                   |      2  4.0|
                                            __________________________________________________________________________|____________|
   Harderian Gland                         |                                                                          |   1        |
      Inflammation, Chronic                |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  |       +     +  +     +  +  +  +  +  +     +  +     +        +  +  +  +  +|  33        |
      Mineralization                       |                               1                                      1   |      3  1.0|
      Nephropathy, Chronic                 |       2     2  3     3  2  2  2  1  4     4  2     3        2  2  2  2  3|     32  2.4|
      Cortex, Cyst                         |                                           2                              |      1  2.0|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         |       +     +  +     +  +  +  +  +  +     +  +     +        +  +  +  +  +|  33        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  56                                                               
NTP Experiment-Test: 05188-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                       SODIUM XYLENESULFONATE                                  Date: 09/19/95  
Route: SKIN APPLICATION                                                                                           Time: 21:28:07  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 5| 7| 6| 5| 7| 7| 6| 6| 5| 7| 7| 4| 7| 6| 7| 6| 6| 5| 7| 5| 6| 6| 6| 7|             
                             DAY ON TEST   | 0| 3| 3| 2| 7| 1| 3| 5| 0| 7| 0| 3| 3| 3| 5| 3| 2| 6| 9| 3| 7| 5| 4| 2| 0|             
                                           | 0| 8| 5| 2| 1| 8| 5| 2| 6| 3| 8| 5| 9| 5| 0| 5| 2| 6| 4| 5| 9| 3| 6| 1| 8|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    120                                    | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
    MG/KG                                  | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +     +  +  +     +  +  +  +     +     +     +  +  +     +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +     +  +  +     +  +  +  +     +     +     +  +  +     +  +  +  +  +|             
      Parasite Metazoan                    |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +     +  +  +     +  +  +  +     +     +     +  +  +     +  +  +  +  +|             
      Parasite Metazoan                    |    X                                                                     |             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +     +  +  +     +  +  +  +     +     +     +  +  +     +  +  +  +  +|             
      Inflammation, Chronic Active         |                                                    2                     |             
      Ulcer                                |                                                    4                     |             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +     +  +  +     +  +  +  +     +     +     +  +  +     +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +     +  +  +     +  +  +  +     +     +     +  +  +     +  +  +  +  +|             
      Diverticulum                         |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +     +  +  +     +  +  +  +     +     +     +  +  +     +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +     +     +  +  +  +  +  +  +  +  +|             
      Basophilic Focus                     |                                                                   X      |             
      Degeneration, Cystic                 |                1              1                       1           1      |             
      Hepatodiaphragmatic Nodule           |                      X                                                  X|             
      Inflammation, Chronic                |    2     1  1              1        1                 2     1            |             
      Necrosis                             |                                                                         2|             
      Bile Duct, Hyperplasia               | 1  2     2  2  2     1  2  2  2     1     3     2  1  2     1           3|             
      Hepatocyte, Vacuolization Cytoplasmic|                3     1                    3        3  3     2     1  2  3|             
                                            __________________________________________________________________________|             
   Mesentery                               |                            +        +           +                        |             
      Mineralization                       |                                                                          |             
      Fat, Inflammation, Chronic Active    |                            3        4                                    |             
      Fat, Necrosis                        |                                                                          |             
                                            __________________________________________________________________________|             
   Oral Mucosa                             |                +                                                     +   |             
      Gingival, Dysplasia                  |                                                                      2   |             
      Gingival, Inflammation, Chronic      |                                                                          |             
          Active                           |                2                                                         |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +     +  +  +     +  +  +  +     +     +     +  +  +     +  +  +  +  +|             
      Inflammation, Chronic Active         |                      1                                                   |             
      Acinus, Atrophy                      |    1                    2  2  1           2        2           1     1  1|             
      Acinus, Hyperplasia                  |                                                                          |             
      Artery, Inflammation, Chronic Active |                                     2                 3                  |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +     +  +  +     +  +  +  +     +     +     +  +  +     +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +     +  +  +     +  +  +  +     +     +     +  +  +     +  +  +  +  +|             
      Inflammation, Chronic Active         |                               4           3        2              3     2|             
      Mineralization                       |                                                       3                  |             
      Ulcer                                |                               4           4        4              4     2|             
      Epithelium, Hyperplasia              |                               3           3     3                 3      |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +     +  +  +     +  +  +  +     +     +     +  +  +     +  +  +  +  +|             
      Mineralization                       |                3                                      3           2      |             
      Necrosis                             |                                                                          |             
      Epithelium, Erosion                  |                                           2        3                    2|             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  57                                                               
NTP Experiment-Test: 05188-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                       SODIUM XYLENESULFONATE                                  Date: 09/19/95  
Route: SKIN APPLICATION                                                                                           Time: 21:28:07  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 5| 7| 6| 5| 7| 7| 6| 6| 5| 7| 7| 4| 7| 6| 7| 6| 6| 5| 7| 5| 6| 6| 6| 7|             
                             DAY ON TEST   | 0| 3| 3| 2| 7| 1| 3| 5| 0| 7| 0| 3| 3| 3| 5| 3| 2| 6| 9| 3| 7| 5| 4| 2| 0|             
                                           | 0| 8| 5| 2| 1| 8| 5| 2| 6| 3| 8| 5| 9| 5| 0| 5| 2| 6| 4| 5| 9| 3| 6| 1| 8|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    120                                    | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
    MG/KG                                  | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |             
                                           |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood Vessel                            | +  +     +  +  +     +  +  +  +     +     +     +  +  +     +  +  +  +  +|             
      Mineralization                       |                3                                      4                  |             
      Thrombosis                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +     +  +  +     +  +  +  +     +     +     +  +  +     +  +  +  +  +|             
      Cardiomyopathy, Chronic              | 2  2     2  2  3     2  2     1     2              2  3     1        2   |             
      Mineralization                       |                3                                      3                  |             
      Atrium, Thrombosis                   |                4                                   4           4        3|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Cortex                          | +  +     +  +  +     +  +  +  +     +     +     +  +  +     +  +  +  +  +|             
      Atrophy                              |                                                                          |             
      Degeneration, Fatty                  | 2  2     1     2     1  1     2           2     3  2  2     2  2  3  1  2|             
      Hyperplasia                          |    1                 1     1                          1     1  2  2      |             
      Hypertrophy                          |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Medulla                         | +  +     +  +  +     +  +  +  +     +     +     +  +  +     +  +  +  +  +|             
      Hyperplasia                          |                2                          1     2  2  2           1     2|             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +     +  +  +     +  +  +  +     +     +     +  +  +     +  +  +  +  +|             
      Hyperplasia                          |    2        2                                      2                     |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +     M  +  +     +  +  +  +     +     +     +  +  +     +  +  +  M  +|             
      Hyperplasia                          |                3                                2     4           3      |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +     +  +  +     +  +  +  +     +     +     +  +  +     +  +  +  +  +|             
      Angiectasis                          | 4        4     2     3  3  2  3     3              4        4  1  4  4  4|             
      Mineralization                       |                                                       3                  |             
      Necrosis                             |                                                                          |             
      Pigmentation, Hematoidin             |                      2                                                   |             
      Pars Distalis, Atrophy               |                                                                          |             
      Pars Distalis, Cyst                  |                                                                   2      |             
      Pars Distalis, Hyperplasia           |             1                                         1        3         |             
      Pars Distalis, Pigmentation,         |                                                                          |             
          Hemosiderin                      |          2  1  1     2  1  1  1     1                       2     1  2  2|             
      Pars Distalis, Thrombosis            |                                                                         4|             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +     +  +  +     +  +  +  +     +     +     +  +  +     +  +  +  +  +|             
      C-Cell, Hyperplasia                  | 1  2                 1                    1                 2  1         |             
      Follicle, Cyst                       |                                                       3                  |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Coagulating Gland                       |                                                                          |             
      Inflammation, Chronic Active         |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              | +  +     +  +  +     +  +  +  +     +     +     +  +  +     +  +  +  +  +|             
      Atrophy                              |                4              3                       4        2  2     3|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  58                                                               
NTP Experiment-Test: 05188-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                       SODIUM XYLENESULFONATE                                  Date: 09/19/95  
Route: SKIN APPLICATION                                                                                           Time: 21:28:07  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 5| 7| 6| 5| 7| 7| 6| 6| 5| 7| 7| 4| 7| 6| 7| 6| 6| 5| 7| 5| 6| 6| 6| 7|             
                             DAY ON TEST   | 0| 3| 3| 2| 7| 1| 3| 5| 0| 7| 0| 3| 3| 3| 5| 3| 2| 6| 9| 3| 7| 5| 4| 2| 0|             
                                           | 0| 8| 5| 2| 1| 8| 5| 2| 6| 3| 8| 5| 9| 5| 0| 5| 2| 6| 4| 5| 9| 3| 6| 1| 8|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    120                                    | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
    MG/KG                                  | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
      Mineralization                       |                                                       3                  |             
                                            __________________________________________________________________________|             
   Preputial Gland                         | +  +     +  +  +     +  +  +  +     +     +     +  +  +     +  +  +  +  +|             
      Hyperplasia                          |                                                                          |             
      Inflammation, Chronic Active         | 2  2     2  1  4     2  2  2  2     1     2     2     2     2  3     2  2|             
      Duct, Cyst                           |                      4                                            2      |             
                                            __________________________________________________________________________|             
   Prostate                                | +  +     +  +  +     +  +  +  +     +     +     +  +  +     +  +  +  +  +|             
      Inflammation, Chronic Active         | 3  2     2  2  4     2  2  1  2     3     1     2  2  2     3  1  3  2  3|             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         | +  +     +  +  +     +  +  +  +     +     +     +  +  +     +  +  +  +  +|             
      Atrophy                              |                3              2           2                             3|             
                                            __________________________________________________________________________|             
   Testes                                  | +  +     +  +  +     +  +  +  +     +     +     +  +  +     +  +  +  +  +|             
      Artery, Inflammation, Chronic        |                      1     1  2                                   1      |             
      Germinal Epithelium, Atrophy         |                4     1        3                       4        2  2  1  3|             
      Interstitial Cell, Hyperplasia       |    2     2                 1              1     1           1            |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +     +  +  +     +  +  +  +     +     +     +  +  +     +  +  +  +  +|             
      Hyperplasia                          | 4  3           4                          4     3  4  3                 3|             
                                            __________________________________________________________________________|             
   Lymph Node                              |    +           +     +  +  +  +     +     +        +           +  +  +  +|             
      Mediastinal, Pigmentation,           |                                                                          |             
          Hemosiderin                      |    1           1     2  2  2  1     3              1              1  2  1|             
      Renal, Ectasia                       |                2                                                         |             
      Renal, Pigmentation, Hemosiderin     |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +     +  +  +     +  +  +  +     +     +     +  +  +     +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +     +  +  +     +  +  +  +     +     +     +  +  +     +  +  +  +  +|             
      Ectasia                              |                                                                         4|             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +     +     +  +  +  +  +  +  +  +  +|             
      Fibrosis                             |                                                 3                        |             
      Hematopoietic Cell Proliferation     |                3                                3              3         |             
      Pigmentation, Hemosiderin            |                                                 3                        |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +     +  +  +     +  +  +  +     +     +     +  +  +     +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +     +  +  +     +  +  +  +     +     +     +  +  +     +  M  +  +  +|             
      Hyperplasia, Cystic                  | 2  1     2  1  3     4  4  2  2     2     3     2  3  3     2     3  3  3|             
      Duct, Cyst                           |                                                    4                    3|             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Epidermis, Skin, Site of Application,|                                                                          |             
           Hyperplasia                     |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +     +  +  +     +  +  +  +     +     +     +  +  +     +  +  +  +  +|             
      Fibrous Osteodystrophy               |                4              3                       4           3      |             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |                                                                +         |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  59                                                               
NTP Experiment-Test: 05188-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                       SODIUM XYLENESULFONATE                                  Date: 09/19/95  
Route: SKIN APPLICATION                                                                                           Time: 21:28:07  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 5| 7| 6| 5| 7| 7| 6| 6| 5| 7| 7| 4| 7| 6| 7| 6| 6| 5| 7| 5| 6| 6| 6| 7|             
                             DAY ON TEST   | 0| 3| 3| 2| 7| 1| 3| 5| 0| 7| 0| 3| 3| 3| 5| 3| 2| 6| 9| 3| 7| 5| 4| 2| 0|             
                                           | 0| 8| 5| 2| 1| 8| 5| 2| 6| 3| 8| 5| 9| 5| 0| 5| 2| 6| 4| 5| 9| 3| 6| 1| 8|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    120                                    | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
    MG/KG                                  | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +     +  +  +     +  +  +  +     +     +     +  +  +     +  +  +  +  +|             
      Hydrocephalus                        |          3           3                                      3     3  3   |             
                                            __________________________________________________________________________|             
   Peripheral Nerve                        |                      +                                                   |             
                                            __________________________________________________________________________|             
   Spinal Cord                             |                      +                                                   |             
      Axon, Degeneration                   |                      1                                                   |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +     +  +  +     +  +  +  +     +     +     +  +  +     +  +  +  +  +|             
      Congestion, Acute                    |          4  4        4  3  4  4     4                       3        4   |             
      Inflammation, Chronic Active         |                                                                          |             
      Inflammation, Granulomatous          |    2                                                                     |             
      Inflammation, Suppurative            |                                                                          |             
      Mineralization                       |                3                                      3                  |             
      Necrosis                             |                                                                          |             
      Alveolar Epithelium, Hyperplasia     |                                                                          |             
      Alveolus, Hemorrhage, Acute          |                                                                          |             
      Alveolus, Infiltration Cellular,     |                                                                          |             
           Histiocyte                      |          1           1        1                 1                 1  1   |             
      Interstitium, Inflammation, Chronic  |                                                                          |             
          Active                           |                      1                                            1      |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +     +  +  +     +  +  +  +     +     +     +  +  +     +  +  +  +  +|             
      Inflammation, Chronic Active         |                4     2                                                   |             
      Thrombosis                           |                                                    4                     |             
      Nasolacrimal Duct, Inflammation,     |                                                                          |             
           Suppurative                     |          2                                                              2|             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +     +  +  +     +  +  +  +     +     +     +  +  +     +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |