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TDMS Study 05197-12 Pathology Tables

NTP Experiment-Test: 05197-12  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                          2-BUTOXYETHANOL                                      Date: 08/23/99
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 11:23:14

                                                      FINAL#1, REVISION #1




       Facility:  Battelle Northwest

       Chemical CAS #:  111-76-0002

       Lock Date:  11/08/96

       Cage Range:  All

       Reasons For Removal:    All

       Removal Date Range:     All

       Treatment Groups:       Include All


































a  Number of animals examined microscopically at site and number of animals with lesion

                                                              Page   1



NTP Experiment-Test: 05197-12  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                          2-BUTOXYETHANOL                                      Date: 08/23/99  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 11:23:14  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE FEMALE                        CONTROL      62.5 PPM     125 PPM      250 PPM                                   
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
DISPOSITION SUMMARY                                                                                                                 

  Animals Initially in Study                          50           50           50           50                                     
  Early Deaths                                                                                                                      
    Natural Death                                      6            3            5            4                                     
    Moribund Sacrifice                                14           16           12           10                                     
    Accidently Killed                                  1                                                                            
  Survivors                                                                                                                         
    Terminal Sacrifice                                29           31           33           36                                     

  Animals Examined Microscopically                    50           50           50           50                                     
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Gallbladder                                        (43)         (43)         (46)         (46)                                   
   Intestine Small, Duodenum                          (45)         (49)         (47)         (47)                                   
      Polyp Adenomatous                                                          1 (2%)                                             
   Intestine Small, Jejunum                           (46)         (49)         (47)         (48)                                   
      Carcinoma                                        1 (2%)                                                                       
   Intestine Small, Ileum                             (46)         (50)         (47)         (48)                                   
      Carcinoma                                                     1 (2%)                                                          
   Liver                                              (50)         (50)         (49)         (50)                                   
      Hemangiosarcoma                                               1 (2%)                                                          
      Hepatocellular Carcinoma                         7 (14%)     10 (20%)     11 (22%)      9 (18%)                               
      Hepatocellular Carcinoma, Multiple               3 (6%)       2 (4%)       2 (4%)       1 (2%)                                
      Hepatocellular Adenoma                           9 (18%)      5 (10%)      5 (10%)      8 (16%)                               
      Hepatocellular Adenoma, Multiple                 7 (14%)      3 (6%)       2 (4%)                                             
      Hepatocholangiocarcinoma                         2 (4%)                                 1 (2%)                                
      Histiocytic Sarcoma                              1 (2%)       1 (2%)       1 (2%)                                             
      Osteosarcoma, Metastatic, Bone                   1 (2%)                                                                       
   Mesentery                                          (10)         (4)          (5)          (9)                                    
      Hemangioma                                       1 (10%)                                                                      
      Hemangiosarcoma                                               1 (25%)                                                         
      Osteosarcoma                                                               1 (20%)                                            
      Sarcoma, Metastatic, Skin                        2 (20%)                                                                      
   Pancreas                                           (49)         (50)         (49)         (50)                                   
   Salivary Glands                                    (48)         (50)         (49)         (50)                                   
      Parotid Gland, Hemangioma                                                  1 (2%)                                             
   Stomach, Forestomach                               (50)         (50)         (49)         (50)                                   
      Hemangioma                                       1 (2%)                                                                       
      Squamous Cell Carcinoma                                                                 1 (2%)                                
      Squamous Cell Papilloma                                       1 (2%)       2 (4%)       5 (10%)                               
   Stomach, Glandular                                 (48)         (50)         (49)         (49)                                   
   Tongue                                             (1)                                    (1)                                    
      Squamous Cell Carcinoma                          1 (100%)                                                                     
____________________________________________________________________________________________________________________________________
NTP Experiment-Test: 05197-12  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                          2-BUTOXYETHANOL                                      Date: 08/23/99  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 11:23:14  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE FEMALE                        CONTROL      62.5 PPM     125 PPM      250 PPM                                   
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Heart                                              (50)         (50)         (50)         (50)                                   
      Hepatocholangiocarcinoma, Metastatic, Liver                                             1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Cortex                                     (50)         (50)         (50)         (50)                                   
   Adrenal Medulla                                    (50)         (50)         (49)         (50)                                   
      Pheochromocytoma Benign                          3 (6%)       1 (2%)                    1 (2%)                                
      Bilateral, Pheochromocytoma Benign                                         1 (2%)                                             
   Islets, Pancreatic                                 (50)         (50)         (49)         (50)                                   
      Adenoma                                          2 (4%)       1 (2%)                                                          
   Pituitary Gland                                    (50)         (49)         (48)         (49)                                   
      Pars Distalis, Adenoma                           5 (10%)      8 (16%)      8 (17%)      4 (8%)                                
      Pars Distalis, Carcinoma                         1 (2%)                                                                       
      Pars Intermedia, Adenoma                                                   1 (2%)                                             
   Thyroid Gland                                      (50)         (50)         (50)         (49)                                   
      Follicular Cell, Adenoma                         1 (2%)       2 (4%)       5 (10%)      1 (2%)                                
      Follicular Cell, Carcinoma                                    1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Ovary                                              (50)         (49)         (49)         (49)                                   
      Cystadenoma                                      2 (4%)       1 (2%)       3 (6%)                                             
      Granulosa Cell Tumor Benign                                                             1 (2%)                                
      Hemangioma                                       1 (2%)                                                                       
      Teratoma Benign                                                            2 (4%)                                             
      Teratoma Malignant                                                         1 (2%)                                             
   Uterus                                             (50)         (50)         (49)         (50)                                   
      Adenoma                                                       1 (2%)                                                          
      Hemangiosarcoma                                                            2 (4%)                                             
      Histiocytic Sarcoma                              1 (2%)       1 (2%)                                                          
      Polyp Stromal                                    1 (2%)       2 (4%)       4 (8%)       2 (4%)                                
      Sarcoma Stromal                                                            1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
NTP Experiment-Test: 05197-12  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                          2-BUTOXYETHANOL                                      Date: 08/23/99  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 11:23:14  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE FEMALE                        CONTROL      62.5 PPM     125 PPM      250 PPM                                   
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (50)         (50)         (50)         (50)                                   
      Hemangiosarcoma                                  1 (2%)                    1 (2%)       1 (2%)                                
   Lymph Node                                         (4)          (7)          (6)          (1)                                    
      Sarcoma, Metastatic, Skin                        1 (25%)                                                                      
      Renal, Sarcoma, Metastatic, Skin                 1 (25%)                                                                      
      Renal, Teratoma Malignant, Metastatic, Ovary                               1 (17%)                                            
   Lymph Node, Bronchial                              (41)         (39)         (41)         (37)                                   
      Hepatocholangiocarcinoma, Metastatic, Liver                                             1 (3%)                                
   Lymph Node, Mandibular                             (37)         (38)         (40)         (38)                                   
      Histiocytic Sarcoma                                           1 (3%)                                                          
   Lymph Node, Mesenteric                             (47)         (48)         (49)         (50)                                   
      Hepatocholangiocarcinoma, Metastatic, Liver      1 (2%)                                                                       
      Histiocytic Sarcoma                                                        1 (2%)                                             
      Sarcoma, Metastatic, Skin                        1 (2%)                                                                       
   Lymph Node, Mediastinal                            (31)         (40)         (38)         (34)                                   
      Hepatocholangiocarcinoma, Metastatic, Liver                                             1 (3%)                                
   Spleen                                             (50)         (50)         (49)         (50)                                   
      Hemangiosarcoma                                  1 (2%)                                                                       
      Histiocytic Sarcoma                              1 (2%)                                                                       
   Thymus                                             (46)         (41)         (46)         (48)                                   
      Hepatocholangiocarcinoma, Metastatic, Liver                                             1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Mammary Gland                                      (50)         (50)         (50)         (50)                                   
      Carcinoma                                                     1 (2%)                    3 (6%)                                
   Skin                                               (50)         (50)         (50)         (50)                                   
      Sebaceous Gland, Adenoma                                                                1 (2%)                                
      Subcutaneous Tissue, Hemangioma                                            1 (2%)                                             
      Subcutaneous Tissue, Hemangiosarcoma                          1 (2%)       1 (2%)                                             
      Subcutaneous Tissue, Sarcoma                     2 (4%)       1 (2%)                                                          
      Subcutaneous Tissue, Sarcoma, Multiple           1 (2%)       1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Bone                                               (50)         (50)         (50)         (50)                                   
      Hemangiosarcoma                                  1 (2%)                                                                       
      Osteosarcoma                                     1 (2%)                                                                       
   Skeletal Muscle                                    (1)                                                                           
      Hemangiosarcoma                                  1 (100%)                                                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
NTP Experiment-Test: 05197-12  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                          2-BUTOXYETHANOL                                      Date: 08/23/99  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 11:23:14  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE FEMALE                        CONTROL      62.5 PPM     125 PPM      250 PPM                                   
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (50)         (50)         (50)         (50)                                   
      Carcinoma, Metastatic, Pituitary Gland           1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (50)         (50)         (50)         (50)                                   
      Alveolar/Bronchiolar Adenoma                     5 (10%)      2 (4%)       4 (8%)       1 (2%)                                
      Alveolar/Bronchiolar Adenoma, Multiple           2 (4%)                                                                       
      Alveolar/Bronchiolar Carcinoma                                2 (4%)       1 (2%)                                             
      Carcinoma, Metastatic, Harderian Gland                                                  1 (2%)                                
      Hepatocellular Carcinoma, Metastatic, Liver      4 (8%)       3 (6%)       6 (12%)      1 (2%)                                
      Hepatocholangiocarcinoma, Metastatic, Liver      1 (2%)                                 1 (2%)                                
      Histiocytic Sarcoma                                           1 (2%)       1 (2%)                                             
      Osteosarcoma, Metastatic, Bone                   1 (2%)                                                                       
      Sarcoma, Metastatic, Skin                        1 (2%)       1 (2%)                                                          
      Mediastinum, Hepatocholangiocarcinoma,                                                                                        
          Metastatic, Liver                                                                   1 (2%)                                
      Mediastinum, Osteosarcoma, Metastatic, Bone      1 (2%)                                                                       
      Mediastinum, Sarcoma, Metastatic, Skin           1 (2%)                                                                       
   Nose                                               (50)         (50)         (49)         (50)                                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Harderian Gland                                    (6)          (4)          (3)          (4)                                    
      Adenoma                                          4 (67%)      3 (75%)      2 (67%)      3 (75%)                               
      Carcinoma                                        1 (17%)      1 (25%)      1 (33%)      2 (50%)                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (50)         (50)         (49)         (50)                                   
      Hepatocholangiocarcinoma, Metastatic, Liver      1 (2%)                                                                       
      Histiocytic Sarcoma                                           1 (2%)                                                          
   Urinary Bladder                                    (47)         (49)         (48)         (50)                                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SYSTEMIC LESIONS                                                                                                                   

   Multiple Organs                                   *(50)        *(50)        *(50)        *(50)                                   
      Histiocytic Sarcoma                              1 (2%)       1 (2%)       2 (4%)                                             
      Lymphoma Malignant                               7 (14%)      9 (18%)     10 (20%)      7 (14%)                               
____________________________________________________________________________________________________________________________________


                                                                                                                                    
     *   Number of animals with any tissue examined microscopically                                                                 


                                                             Page   5                                                               
NTP Experiment-Test: 05197-12  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                          2-BUTOXYETHANOL                                      Date: 08/23/99  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 11:23:14  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE FEMALE                        CONTROL      62.5 PPM     125 PPM      250 PPM                                   
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
TUMOR SUMMARY                                                                                                                       
                                                                                                                                    
   Total Animals with Primary Neoplasms (b)            43          38          38          35                                       
     Total Primary Neoplasms                           76          63          76          52                                       
                                                                                                                                    
   Total Animals with Benign Neoplasms                 31          23          27          18                                       
     Total Benign Neoplasms                            44          30          42          27                                       
                                                                                                                                    
   Total Animals with Malignant Neoplasms              27          26          28          22                                       
     Total Malignant Neoplasms                         32          33          34          25                                       
                                                                                                                                    
   Total Animals with Metastatic Neoplasms              9           4           7           3                                       
     Total Metastatic Neoplasm                         18           4           7           8                                       
                                                                                                                                    
   Total Animals with Malignant Neoplasms                                                                                           
   Uncertain Primary Site                                                                                                           
                                                                                                                                    
   Total Animals with Neoplasms Uncertain-                                                                                          
   Benign or Malignant                                                                                                              
     Total Uncertain Neoplasms                                                                                                      
                                                                                                                                    

____________________________________________________________________________________________________________________________________
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Primary tumors: all tumors except metastatic tumors                                                                              
NTP Experiment-Test: 05197-12  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                          2-BUTOXYETHANOL                                      Date: 08/23/99  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 11:23:14  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE MALE                          CONTROL      62.5 PPM     125 PPM      250 PPM                                   
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
DISPOSITION SUMMARY                                                                                                                 

  Animals Initially in Study                          50           50           50           50                                     
  Early Deaths                                                                                                                      
    Moribund Sacrifice                                 7            8           13           10                                     
    Natural Death                                      4            3           10           14                                     
  Survivors                                                                                                                         
    Terminal Sacrifice                                39           39           27           26                                     

  Animals Examined Microscopically                    50           50           50           50                                     
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Intestine Large, Cecum                             (48)         (48)         (44)         (43)                                   
   Intestine Small, Jejunum                           (48)         (47)         (43)         (38)                                   
      Histiocytic Sarcoma                                                                     1 (3%)                                
   Intestine Small, Ileum                             (48)         (47)         (43)         (39)                                   
      Carcinoma                                                     1 (2%)                                                          
   Liver                                              (50)         (50)         (49)         (49)                                   
      Carcinoma, Metastatic, Islets, Pancreatic                                               1 (2%)                                
      Hemangiosarcoma                                               1 (2%)       2 (4%)       4 (8%)                                
      Hepatocellular Carcinoma                         5 (10%)      8 (16%)     12 (24%)     16 (33%)                               
      Hepatocellular Carcinoma, Multiple               5 (10%)      3 (6%)       4 (8%)       5 (10%)                               
      Hepatocellular Adenoma                          13 (26%)     10 (20%)     13 (27%)     14 (29%)                               
      Hepatocellular Adenoma, Multiple                 9 (18%)      8 (16%)      5 (10%)      3 (6%)                                
      Hepatocholangiocarcinoma                         1 (2%)                                                                       
      Histiocytic Sarcoma                                                                     2 (4%)                                
   Mesentery                                          (5)          (3)          (3)          (1)                                    
      Histiocytic Sarcoma                                                                     1 (100%)                              
   Oral Mucosa                                                                  (1)                                                 
      Squamous Cell Carcinoma                                                    1 (100%)                                           
   Pancreas                                           (50)         (50)         (47)         (47)                                   
      Hemangioma                                                                 1 (2%)                                             
      Histiocytic Sarcoma                                                                     1 (2%)                                
   Salivary Glands                                    (50)         (50)         (48)         (50)                                   
   Stomach, Forestomach                               (50)         (50)         (49)         (48)                                   
      Histiocytic Sarcoma                                                                     1 (2%)                                
      Squamous Cell Carcinoma                                                    1 (2%)                                             
      Squamous Cell Papilloma                          1 (2%)       1 (2%)       2 (4%)       2 (4%)                                
   Stomach, Glandular                                 (50)         (50)         (46)         (47)                                   
      Adenoma                                          1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
NTP Experiment-Test: 05197-12  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                          2-BUTOXYETHANOL                                      Date: 08/23/99  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 11:23:14  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE MALE                          CONTROL      62.5 PPM     125 PPM      250 PPM                                   
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Heart                                              (50)         (50)         (50)         (50)                                   
      Hemangiosarcoma                                                                         1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Cortex                                     (50)         (50)         (49)         (50)                                   
      Hepatocellular Carcinoma, Metastatic, Liver                   1 (2%)                                                          
      Histiocytic Sarcoma                                                                     1 (2%)                                
      Capsule, Adenoma                                 2 (4%)       2 (4%)       2 (4%)                                             
   Adrenal Medulla                                    (49)         (50)         (49)         (49)                                   
      Pheochromocytoma Malignant                                    1 (2%)                                                          
   Islets, Pancreatic                                 (50)         (50)         (47)         (46)                                   
      Adenoma                                          2 (4%)                                                                       
      Carcinoma                                                                               1 (2%)                                
   Thyroid Gland                                      (50)         (48)         (49)         (50)                                   
      Follicular Cell, Adenoma                         2 (4%)       1 (2%)       1 (2%)       1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Epididymis                                         (50)         (50)         (49)         (50)                                   
      Hemangiosarcoma                                                                         1 (2%)                                
      Histiocytic Sarcoma                                                                     1 (2%)                                
      Leiomyoma                                                                               1 (2%)                                
   Prostate                                           (49)         (49)         (48)         (45)                                   
   Seminal Vesicle                                    (50)         (49)         (46)         (46)                                   
      Histiocytic Sarcoma                                                                     1 (2%)                                
   Testes                                             (50)         (50)         (49)         (50)                                   
      Interstitial Cell, Adenoma                                                              2 (4%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (50)         (50)         (49)         (50)                                   
      Hemangiosarcoma                                               1 (2%)                    2 (4%)                                
      Histiocytic Sarcoma                                                                     1 (2%)                                
   Lymph Node                                         (2)          (1)                       (1)                                    
      Schwannoma Malignant, Metastatic, Spinal Cord    1 (50%)                                                                      
   Lymph Node, Bronchial                              (38)         (35)         (33)         (35)                                   
      Hepatocholangiocarcinoma, Metastatic, Liver      1 (3%)                                                                       
NTP Experiment-Test: 05197-12  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                          2-BUTOXYETHANOL                                      Date: 08/23/99  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 11:23:14  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE MALE                          CONTROL      62.5 PPM     125 PPM      250 PPM                                   
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
HEMATOPOIETIC SYSTEM - cont                                                                                                         
   Lymph Node, Mandibular                             (24)         (26)         (32)         (25)                                   
   Lymph Node, Mesenteric                             (50)         (50)         (47)         (43)                                   
      Histiocytic Sarcoma                                                                     1 (2%)                                
   Lymph Node, Mediastinal                            (40)         (33)         (40)         (37)                                   
      Hepatocholangiocarcinoma, Metastatic, Liver      1 (3%)                                                                       
      Histiocytic Sarcoma                                                                     1 (3%)                                
   Spleen                                             (50)         (50)         (48)         (49)                                   
      Hemangiosarcoma                                               1 (2%)                    1 (2%)                                
      Histiocytic Sarcoma                                                                     1 (2%)                                
      Mast Cell Tumor NOS                                           1 (2%)                                                          
   Thymus                                             (43)         (43)         (36)         (37)                                   
      Histiocytic Sarcoma                                                                     1 (3%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Skin                                               (50)         (50)         (49)         (50)                                   
      Hemangioma                                                                 1 (2%)                                             
      Prepuce, Histiocytic Sarcoma                     1 (2%)                                                                       
      Subcutaneous Tissue, Hemangiosarcoma             1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Bone                                               (50)         (50)         (50)         (50)                                   
      Hemangiosarcoma                                               1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (50)         (50)         (49)         (50)                                   
   Spinal Cord                                        (2)                                                                           
      Schwannoma Malignant                             1 (50%)                                                                      
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Larynx                                             (50)         (50)         (48)         (49)                                   
   Lung                                               (50)         (50)         (49)         (50)                                   
      Alveolar/Bronchiolar Adenoma                     7 (14%)      7 (14%)      8 (16%)      8 (16%)                               
      Alveolar/Bronchiolar Adenoma, Multiple           2 (4%)                    2 (4%)                                             
      Alveolar/Bronchiolar Carcinoma                   5 (10%)      2 (4%)       2 (4%)       3 (6%)                                
      Alveolar/Bronchiolar Carcinoma, Multiple                                   1 (2%)                                             
      Hepatocellular Carcinoma, Metastatic, Liver      7 (14%)      5 (10%)      5 (10%)      3 (6%)                                
      Hepatocholangiocarcinoma, Metastatic, Liver      1 (2%)                                                                       
      Histiocytic Sarcoma                                                                     1 (2%)                                
      Mediastinum, Hepatocholangiocarcinoma,                                                                                        
NTP Experiment-Test: 05197-12  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                          2-BUTOXYETHANOL                                      Date: 08/23/99  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 11:23:14  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE MALE                          CONTROL      62.5 PPM     125 PPM      250 PPM                                   
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
RESPIRATORY SYSTEM - cont                                                                                                           
          Metastatic, Liver                            1 (2%)                                                                       
   Nose                                               (50)         (50)         (48)         (48)                                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Harderian Gland                                    (3)          (3)          (2)          (2)                                    
      Adenoma                                          3 (100%)     3 (100%)     2 (100%)     2 (100%)                              
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 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (50)         (50)         (47)         (50)                                   
      Histiocytic Sarcoma                                                                     1 (2%)                                
   Urinary Bladder                                    (50)         (50)         (46)         (45)                                   
      Histiocytic Sarcoma                                                                     1 (2%)                                
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 SYSTEMIC LESIONS                                                                                                                   

   Multiple Organs                                   *(50)        *(50)        *(50)        *(50)                                   
      Histiocytic Sarcoma                              1 (2%)                                 2 (4%)                                
      Lymphoma Malignant                               1 (2%)       3 (6%)                                                          
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     *   Number of animals with any tissue examined microscopically                                                                 


                                                             Page  10                                                               
NTP Experiment-Test: 05197-12  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                          2-BUTOXYETHANOL                                      Date: 08/23/99  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 11:23:14  
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         B6C3F1 MICE MALE                          CONTROL      62.5 PPM     125 PPM      250 PPM                                   
                                                                                                                                    
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TUMOR SUMMARY                                                                                                                       
                                                                                                                                    
   Total Animals with Primary Neoplasms (b)            42          33          36          41                                       
     Total Primary Neoplasms                           62          55          60          69                                       
                                                                                                                                    
   Total Animals with Benign Neoplasms                 30          28          26          28                                       
     Total Benign Neoplasms                            42          32          37          33                                       
                                                                                                                                    
   Total Animals with Malignant Neoplasms              19          16          19          28                                       
     Total Malignant Neoplasms                         20          22          23          36                                       
                                                                                                                                    
   Total Animals with Metastatic Neoplasms              9           5           5           4                                       
     Total Metastatic Neoplasm                         12           6           5           4                                       
                                                                                                                                    
   Total Animals with Malignant Neoplasms                                                                                           
   Uncertain Primary Site                                                                                                           
                                                                                                                                    
   Total Animals with Neoplasms Uncertain-                                                                                          
   Benign or Malignant                                              1                                                               
     Total Uncertain Neoplasms                                      1                                                               
                                                                                                                                    

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a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Primary tumors: all tumors except metastatic tumors                                                                              
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                             ----------              END OF REPORT             ----------                                           
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