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TDMS Study 05197-12 Pathology Tables

NTP Experiment-Test: 05197-12                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          2-BUTOXYETHANOL                                      Date: 01/21/98
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 10:57:48

                                                      CORE STUDY FINAL #1




       Facility:  Battelle Northwest

       Chemical CAS #:  111-76-0002

       Lock Date:  11/08/96

       Cage Range:  All

       Reasons For Removal:    All

       Removal Date Range:     All

       Treatment Groups:       Include All




































                                                              Page   1


NTP Experiment-Test: 05197-12                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          2-BUTOXYETHANOL                                      Date: 01/21/98  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 10:57:48  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 5| 7| 7| 7| 7| 6| 7| 7| 5| 7| 7| 7| 7| 5| 7| 6| 5| 7| 5| 7| 7| 7| 7|             
                             DAY ON TEST   | 3| 3| 9| 3| 3| 3| 0| 2| 3| 3| 2| 3| 3| 3| 3| 7| 3| 4| 6| 2| 6| 3| 3| 3| 2|             
                                           | 2| 2| 0| 1| 2| 1| 0| 1| 2| 1| 1| 1| 3| 1| 2| 7| 1| 5| 1| 5| 5| 1| 2| 3| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    CONTROL                                | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Epithelium, Hyperplasia              |                                                                          |             
                                            __________________________________________________________________________|             
   Gallbladder                             | +  +  A  +  +  +  +  +  +  +  +  +  M  +  +  A  +  +  +  +  +  +  +  +  A|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Epithelium, Hyperplasia              |          1                                                               |             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  A|             
      Epithelium, Hyperplasia              |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Basophilic Focus                     |                                                 X                        |             
      Clear Cell Focus                     |                                                                          |             
      Degeneration, Fatty                  |                                                          1               |             
      Eosinophilic Focus                   |          X              X                                                |             
      Hematopoietic Cell Proliferation     |                               1                    2                    2|             
      Inflammation                         |                1              1                                          |             
      Necrosis                             |                                        1           1                     |             
      Bile Duct, Cyst                      |                2                                                         |             
                                            __________________________________________________________________________|             
   Mesentery                               |             +                 +                    +                 +   |             
      Fat, Necrosis                        |                               4                                      3   |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                                                                      2   |             
      Cytoplasmic Alteration               |             1                                                            |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Erosion                              |                                                 1                        |             
      Ulcer                                |                                                             3            |             
      Epithelium, Hyperplasia              |                                                 2           4     1      |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +|             
      Ulcer                                |                                                                          |             
      Epithelium, Hyperplasia              |                                                                          |             
                                            __________________________________________________________________________|             
   Tongue                                  |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cardiomyopathy                       | 1  1  1  2  1  2  1  1  1  2  2  1  1  1  1  1  1  1  1  1     1  1  1   |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Amyloid Deposition                   |                                                                          |             
      Hematopoietic Cell Proliferation     |                                                    2                     |             
      Hyperplasia                          |                                                                          |             
 _____________________________________________________________________________________________________________________|             

                                                             Page   2                                                               
NTP Experiment-Test: 05197-12                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          2-BUTOXYETHANOL                                      Date: 01/21/98  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 10:57:48  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 5| 7| 7| 7| 7| 6| 7| 7| 5| 7| 7| 7| 7| 5| 7| 6| 5| 7| 5| 7| 7| 7| 7|             
                             DAY ON TEST   | 3| 3| 9| 3| 3| 3| 0| 2| 3| 3| 2| 3| 3| 3| 3| 7| 3| 4| 6| 2| 6| 3| 3| 3| 2|             
                                           | 2| 2| 0| 1| 2| 1| 0| 1| 2| 1| 1| 1| 3| 1| 2| 7| 1| 5| 1| 5| 5| 1| 2| 3| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    CONTROL                                | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
      Hypertrophy                          |                            1        1                                   1|             
                                            __________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                        2                                 |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                                                          |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  M  +  M  M  +  +  M  +  M  +  +  M  +  +  M  M  M  M  +  M  +  +  +|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Pars Distalis, Angiectasis           |                                                                          |             
      Pars Distalis, Hyperplasia           | 2           1  1        1           2  4                 1               |             
      Pars Intermedia, Hyperplasia         |                                                                          |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Follicular Cell, Hyperplasia         |             1           1           1  3        2                        |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Clitoral Gland                          | +  M  +  +  M  M  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                2           3                                             |             
      Atrophy                              |                                                                          |             
      Cyst                                 |          3           3        1                 1     4              1   |             
      Inflammation                         |                                           4                              |             
      Thrombosis                           |                            4                                             |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |             1                                            3               |             
      Hydrometra                           |             3                                                            |             
      Hyperplasia, Cystic                  |                                           2                              |             
      Inflammation                         |                                                                          |             
      Thrombosis                           |                                                          4               |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node                              |             +                                      +                     |             
      Angiectasis                          |                                                                          |             
      Hyperplasia                          |                                                                          |             
      Iliac, Hyperplasia                   |             2                                                            |             
                                            __________________________________________________________________________|             
   Lymph Node, Bronchial                   | +  +  +  M  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +|             
      Hematopoietic Cell Proliferation     |                                                    2                     |             
      Hyperplasia                          | 4                                                                        |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  M  M  +  M  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             

                                                             Page   3                                                               
NTP Experiment-Test: 05197-12                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          2-BUTOXYETHANOL                                      Date: 01/21/98  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 10:57:48  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 5| 7| 7| 7| 7| 6| 7| 7| 5| 7| 7| 7| 7| 5| 7| 6| 5| 7| 5| 7| 7| 7| 7|             
                             DAY ON TEST   | 3| 3| 9| 3| 3| 3| 0| 2| 3| 3| 2| 3| 3| 3| 3| 7| 3| 4| 6| 2| 6| 3| 3| 3| 2|             
                                           | 2| 2| 0| 1| 2| 1| 0| 1| 2| 1| 1| 1| 3| 1| 2| 7| 1| 5| 1| 5| 5| 1| 2| 3| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    CONTROL                                | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Hyperplasia                          |                         2                                                |             
                                            __________________________________________________________________________|             
   Lymph Node, Mediastinal                 | M  +  +  +  +  M  +  M  M  +  +  +  +  +  +  +  M  +  M  +  M  M  +  M  +|             
      Hyperplasia                          |                                                    2                     |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hematopoietic Cell Proliferation     |          2     3     2     2  3     2  2        2  4     2  2            |             
      Hyperplasia, Lymphoid                |    2                    2        2        2           2           2      |             
      Pigmentation, Hemosiderin            |    2     2     1  1     1        2  1  1  1     2     2  2  2  1  1  2   |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  M  +  M  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                                                    2                     |             
      Hyperplasia, Lymphoid                | 4                                                                        |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                               1                                          |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic Active         |                                                                          |             
      Pinna, Inflammation, Chronic         |                                                                          |             
      Subcutaneous Tissue, Edema           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrous Osteodystrophy               | 1  2        1  2                 2  1           1        1     1     1  1|             
      Maxilla, Fracture                    |                                                          X               |             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |                                                          2               |             
      Necrosis                             |                                                             1            |             
      Meninges, Infiltration Cellular,     |                                                                          |             
           Mononuclear Cell                |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Larynx                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Suppurative            |                                                                          |             
      Squamous Epithelium, Hyperplasia     |                                        1                                 |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |                1  1                 1     1              1        1      |             
      Infiltration Cellular, Histiocyte    |                                                 3                        |             
      Metaplasia, Osseous                  |                                                                          |             
      Pigmentation, Hemosiderin            |                                                                          |             
      Alveolar Epithelium, Hyperplasia     |                                  1                                       |             
      Perivascular, Inflammation           |                                                                          |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             

                                                             Page   4                                                               
NTP Experiment-Test: 05197-12                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          2-BUTOXYETHANOL                                      Date: 01/21/98  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 10:57:48  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 5| 7| 7| 7| 7| 6| 7| 7| 5| 7| 7| 7| 7| 5| 7| 6| 5| 7| 5| 7| 7| 7| 7|             
                             DAY ON TEST   | 3| 3| 9| 3| 3| 3| 0| 2| 3| 3| 2| 3| 3| 3| 3| 7| 3| 4| 6| 2| 6| 3| 3| 3| 2|             
                                           | 2| 2| 0| 1| 2| 1| 0| 1| 2| 1| 1| 1| 3| 1| 2| 7| 1| 5| 1| 5| 5| 1| 2| 3| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    CONTROL                                | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
      Inflammation, Chronic Active         |             1                                                            |             
      Inflammation, Suppurative            |          1                                               3               |             
      Olfactory Epithelium, Atrophy        |                      1                                                   |             
      Olfactory Epithelium, Degeneration,  |                                                                          |             
           Hyaline                         |          1           1  2           1                             1      |             
      Olfactory Epithelium, Metaplasia     |                                                                          |             
      Respiratory Epithelium, Degeneration,|                                                                          |             
           Hyaline                         |          1  1        1  1  1        1     1                    1  1  1   |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                                                                          |             
      Cornea, Inflammation, Chronic        |                                                                          |             
                                            __________________________________________________________________________|             
   Harderian Gland                         | +                          +        +                                    |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Glomerulosclerosis                   | 1                    1                                      1            |             
      Metaplasia, Osseous                  |                                                                          |             
      Nephropathy                          |    1        1  3     1  1  1  1  1  1  3  1     1  1     1  1  1        1|             
      Pigmentation, Hemosiderin            |                                                                          |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +|             
      Inflammation                         |                                                                          |             
 _____________________________________________________________________________________________________________________|             

                                                             Page   5                                                               
NTP Experiment-Test: 05197-12                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          2-BUTOXYETHANOL                                      Date: 01/21/98  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 10:57:48  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 7| 7| 7| 7| 7| 5| 7| 7| 6| 6| 7| 3| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 6| 7|            |
                             DAY ON TEST   | 8| 3| 1| 3| 3| 3| 7| 3| 3| 1| 4| 3| 7| 3| 3| 3| 8| 3| 3| 3| 1| 1| 3| 0| 3|            |
                                           | 9| 2| 3| 2| 2| 0| 2| 2| 1| 1| 9| 3| 6| 3| 3| 2| 6| 2| 2| 2| 5| 5| 2| 6| 1|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|      A     |
    CONTROL                                | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Epithelium, Hyperplasia              |                                                                      2   |      1  2.0|
                                            __________________________________________________________________________|____________|
   Gallbladder                             | +  +  +  +  +  A  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  A  +|  43        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +|  47        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Epithelium, Hyperplasia              |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +|  45        |
      Epithelium, Hyperplasia              |                                                    1                     |      1  1.0|
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +|  46        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +|  46        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Basophilic Focus                     |                                                                          |      1     |
      Clear Cell Focus                     |                      X                                            X      |      2     |
      Degeneration, Fatty                  |                                                 2                        |      2  1.5|
      Eosinophilic Focus                   |                X     X  X     X                 X  X                 X  X|     10     |
      Hematopoietic Cell Proliferation     |          4                                                  2            |      5  2.2|
      Inflammation                         |                   1                                                      |      3  1.0|
      Necrosis                             |                                                                          |      2  1.0|
      Bile Duct, Cyst                      |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Mesentery                               |          +           +        +                 +  +                 +   |  10        |
      Fat, Necrosis                        |                      3        2                 2  3                 2   |      7  2.7|
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Atrophy                              |             1                    1        1        1           4         |      6  1.7|
      Cytoplasmic Alteration               |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Erosion                              |                                                                          |      1  1.0|
      Ulcer                                |                                                                          |      1  3.0|
      Epithelium, Hyperplasia              |                                                 1  1              2      |      6  1.8|
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Ulcer                                |                                                 1                        |      1  1.0|
      Epithelium, Hyperplasia              |                      1                                                   |      1  1.0|
                                            __________________________________________________________________________|____________|
   Tongue                                  |                               +                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cardiomyopathy                       | 1  1  1  1  1     2  1  1  1  1  1     1  1  1  1  1  1  1  2  1  1  1  1|     46  1.1|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 

  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        

                                                             Page   6                                                               
NTP Experiment-Test: 05197-12                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          2-BUTOXYETHANOL                                      Date: 01/21/98  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 10:57:48  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 7| 7| 7| 7| 7| 5| 7| 7| 6| 6| 7| 3| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 6| 7|            |
                             DAY ON TEST   | 8| 3| 1| 3| 3| 3| 7| 3| 3| 1| 4| 3| 7| 3| 3| 3| 8| 3| 3| 3| 1| 1| 3| 0| 3|            |
                                           | 9| 2| 3| 2| 2| 0| 2| 2| 1| 1| 9| 3| 6| 3| 3| 2| 6| 2| 2| 2| 5| 5| 2| 6| 1|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|      A     |
    CONTROL                                | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 __________________________________________________________________________________________________________________________________ 
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
                                           |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Amyloid Deposition                   |                1                                                         |      1  1.0|
      Hematopoietic Cell Proliferation     |                                                                          |      1  2.0|
      Hyperplasia                          |                                                             4            |      1  4.0|
      Hypertrophy                          |                                                                          |      3  1.0|
                                            __________________________________________________________________________|____________|
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia                          |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia                          |                                                 2                        |      1  2.0|
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | M  +  +  M  +  +  +  +  M  M  +  +  +  +  +  +  +  +  M  +  M  M  +  M  +|  31        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Pars Distalis, Angiectasis           |                                                          3               |      1  3.0|
      Pars Distalis, Hyperplasia           |                      1        4        1  2  2        1        4  2      |     15  1.9|
      Pars Intermedia, Hyperplasia         |          2                                                               |      1  2.0|
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Follicular Cell, Hyperplasia         | 1        2  1  2                          1           1                  |     11  1.5|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Clitoral Gland                          | M  +  M  +  +  +  +  +  +  +  +  +  M  +  +  M  +  +  +  +  M  +  +  +  +|  41        |
                                            __________________________________________________________________________|____________|
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Angiectasis                          |                                                                          |      2  2.5|
      Atrophy                              |       3                                                                  |      1  3.0|
      Cyst                                 |                      2        3                    2  2  3               |     11  2.3|
      Inflammation                         |                                                                          |      1  4.0|
      Thrombosis                           |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Angiectasis                          |                                                                          |      2  2.0|
      Hydrometra                           |                                  3                                       |      2  3.0|
      Hyperplasia, Cystic                  |                   3                                                      |      2  2.5|
      Inflammation                         |                2                                                         |      1  2.0|
      Thrombosis                           |                                                                          |      1  4.0|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia                          |                                                       2        2         |      2  2.0|
 __________________________________________________________________________________________________________________________________ 

  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        

                                                             Page   7                                                               
NTP Experiment-Test: 05197-12                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          2-BUTOXYETHANOL                                      Date: 01/21/98  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 10:57:48  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 7| 7| 7| 7| 7| 5| 7| 7| 6| 6| 7| 3| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 6| 7|            |
                             DAY ON TEST   | 8| 3| 1| 3| 3| 3| 7| 3| 3| 1| 4| 3| 7| 3| 3| 3| 8| 3| 3| 3| 1| 1| 3| 0| 3|            |
                                           | 9| 2| 3| 2| 2| 0| 2| 2| 1| 1| 9| 3| 6| 3| 3| 2| 6| 2| 2| 2| 5| 5| 2| 6| 1|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|      A     |
    CONTROL                                | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lymph Node                              |                   +                    +                                 |   4        |
      Angiectasis                          |                                        3                                 |      1  3.0|
      Hyperplasia                          |                                        2                                 |      1  2.0|
      Iliac, Hyperplasia                   |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Bronchial                   | +  +  +  M  +  M  +  M  +  +  +  +  +  +  M  +  M  +  +  +  +  M  +  +  +|  41        |
      Hematopoietic Cell Proliferation     |                                                                          |      1  2.0|
      Hyperplasia                          |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | M  M  M  +  +  +  M  M  +  +  M  +  +  +  +  +  +  M  +  +  +  M  M  +  +|  37        |
      Hyperplasia                          |                                        2                                 |      1  2.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  M  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  47        |
      Hyperplasia                          |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mediastinal                 | +  +  M  M  M  M  +  M  +  +  +  +  M  +  M  +  M  +  +  +  +  +  M  M  +|  31        |
      Hyperplasia                          |                                                                2         |      2  2.0|
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hematopoietic Cell Proliferation     | 2        3     3     2  2        2  3        2     3  2  2  4  4         |     24  2.5|
      Hyperplasia, Lymphoid                |                                                                          |      6  2.0|
      Pigmentation, Hemosiderin            | 2  1  1  2  1  1     2  2  2  1  2     1  2  1  2  1  1  2  1  1  2  2  2|     39  1.5|
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +  +  +  +  +  +  +  +  M  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +|  46        |
      Atrophy                              |                                                                          |      1  2.0|
      Hyperplasia, Lymphoid                |                                                                          |      1  4.0|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia                          |       2                                                                  |      2  1.5|
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inflammation, Chronic Active         | 4                                                                        |      1  4.0|
      Pinna, Inflammation, Chronic         |                   4                                                      |      1  4.0|
      Subcutaneous Tissue, Edema           |                                                                      4   |      1  4.0|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Fibrous Osteodystrophy               | 1  1     1     2     1  2     1              1        2  3        2      |     22  1.4|
      Maxilla, Fracture                    |                                                                          |      1     |
                                            __________________________________________________________________________|____________|
   Skeletal Muscle                         | +                                                                        |   1        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hemorrhage                           |                                                                          |      1  2.0|
      Necrosis                             |                                                                          |      1  1.0|
 __________________________________________________________________________________________________________________________________ 

  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        

                                                             Page   8                                                               
NTP Experiment-Test: 05197-12                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          2-BUTOXYETHANOL                                      Date: 01/21/98  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 10:57:48  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 7| 7| 7| 7| 7| 5| 7| 7| 6| 6| 7| 3| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 6| 7|            |
                             DAY ON TEST   | 8| 3| 1| 3| 3| 3| 7| 3| 3| 1| 4| 3| 7| 3| 3| 3| 8| 3| 3| 3| 1| 1| 3| 0| 3|            |
                                           | 9| 2| 3| 2| 2| 0| 2| 2| 1| 1| 9| 3| 6| 3| 3| 2| 6| 2| 2| 2| 5| 5| 2| 6| 1|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|      A     |
    CONTROL                                | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 __________________________________________________________________________________________________________________________________ 
 NERVOUS SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
      Meninges, Infiltration Cellular,     |                                                                          |            |
           Mononuclear Cell                | 1                                                     1                  |      2  1.0|
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Larynx                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inflammation, Suppurative            |                1                                                         |      1  1.0|
      Squamous Epithelium, Hyperplasia     |             1                                                            |      2  1.0|
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hemorrhage                           |                   1  1                             1  1                  |     10  1.0|
      Infiltration Cellular, Histiocyte    |       2  4                                                               |      3  3.0|
      Metaplasia, Osseous                  |                            1                                             |      1  1.0|
      Pigmentation, Hemosiderin            |          4                                                               |      1  4.0|
      Alveolar Epithelium, Hyperplasia     |          1                                                               |      2  1.0|
      Perivascular, Inflammation           |       2                                               2                  |      2  2.0|
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inflammation, Chronic Active         |                                                                          |      1  1.0|
      Inflammation, Suppurative            |                                                                          |      2  2.0|
      Olfactory Epithelium, Atrophy        |          2                                                               |      2  1.5|
      Olfactory Epithelium, Degeneration,  |                                                                          |            |
           Hyaline                         |          2                                                               |      6  1.3|
      Olfactory Epithelium, Metaplasia     |                                              1                           |      1  1.0|
      Respiratory Epithelium, Degeneration,|                                                                          |            |
           Hyaline                         |          2           1        1        1     1                 1        1|     17  1.1|
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Eye                                     |          +                                                               |   1        |
      Cornea, Inflammation, Chronic        |          2                                                               |      1  2.0|
                                            __________________________________________________________________________|____________|
   Harderian Gland                         |    +     +                                   +                           |   6        |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Glomerulosclerosis                   |       1                    1        1              1                     |      7  1.0|
      Metaplasia, Osseous                  |    1                                                                     |      1  1.0|
      Nephropathy                          | 1     1  1  1     1  1  1     1           1  1  1  2  1     1     1  1  1|     34  1.1|
      Pigmentation, Hemosiderin            |                                                                2         |      1  2.0|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  47        |
      Inflammation                         |                            2                                             |      1  2.0|
 __________________________________________________________________________________________________________________________________ 

  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        

                                                             Page   9                                                               
NTP Experiment-Test: 05197-12                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          2-BUTOXYETHANOL                                      Date: 01/21/98  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 10:57:48  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 5| 7| 7| 6| 7| 6| 7| 7| 7| 3| 6| 7| 7| 7| 6| 5| 7| 7| 7| 4| 7| 7| 7|             
                             DAY ON TEST   | 3| 1| 3| 3| 3| 0| 3| 7| 3| 3| 3| 6| 0| 3| 1| 3| 7| 9| 3| 3| 3| 7| 3| 1| 3|             
                                           | 3| 2| 4| 1| 2| 4| 2| 0| 1| 1| 2| 9| 6| 2| 5| 3| 2| 2| 2| 3| 2| 2| 2| 2| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    62.5 PPM                               | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Gallbladder                             | M  +  +  +  +  +  M  +  +  +  M  +  M  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +|             
      Inflammation                         |                                                    4           1         |             
      Necrosis                             |                                                    4                     |             
      Epithelium, Hyperplasia              |                                                                2         |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |    1                                                                     |             
      Clear Cell Focus                     |                                                                   X      |             
      Degeneration, Fatty                  |                                                                          |             
      Eosinophilic Focus                   |                      X                       X     X              X      |             
      Hematopoietic Cell Proliferation     |       2                 2              1        2  1                     |             
      Hyperplasia, Lymphoid                |                                                                          |             
      Inflammation                         |                      1                                               2   |             
      Necrosis                             |    2                 1                          2  2                     |             
      Kupffer Cell, Pigmentation,          |                                                                          |             
          Hemosiderin                      |          1                       1              1  1                     |             
                                            __________________________________________________________________________|             
   Mesentery                               |       +              +                                                   |             
      Fat, Necrosis                        |       4                                                                  |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                                                          1               |             
      Cytoplasmic Alteration               |    1                          1                                          |             
      Duct, Cyst                           |                                                                          |             
      Duct, Inflammation                   |                                                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Ulcer                                |    1  2        2                                                         |             
      Epithelium, Hyperplasia              | 2  1  3        4     1        2        1  3     2           2  3  2     2|             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Suppurative            |                                                                          |             
      Mineralization                       |                                                    1                     |             
      Ulcer                                |       1                                                                  |             
                                            __________________________________________________________________________|             
   Tooth                                   |                                                                          |             
      Inflammation                         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood Vessel                            |       +                                                                  |             
      Mineralization                       |       3                                                                  |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             

                                                             Page  10                                                               
NTP Experiment-Test: 05197-12                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          2-BUTOXYETHANOL                                      Date: 01/21/98  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 10:57:48  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 5| 7| 7| 6| 7| 6| 7| 7| 7| 3| 6| 7| 7| 7| 6| 5| 7| 7| 7| 4| 7| 7| 7|             
                             DAY ON TEST   | 3| 1| 3| 3| 3| 0| 3| 7| 3| 3| 3| 6| 0| 3| 1| 3| 7| 9| 3| 3| 3| 7| 3| 1| 3|             
                                           | 3| 2| 4| 1| 2| 4| 2| 0| 1| 1| 2| 9| 6| 2| 5| 3| 2| 2| 2| 3| 2| 2| 2| 2| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    62.5 PPM                               | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |             
                                           |                                                                          |             
      Cardiomyopathy                       | 1  1  1     1  1  1  1  1  1  1     2  1  1  1  1  2  1  1  1  1  1  1  2|             
      Mineralization                       |                                     1                                    |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hematopoietic Cell Proliferation     |       3                                                                  |             
      Hypertrophy                          |                                                                      1   |             
                                            __________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |          1                                                               |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | M  +  M  M  +  +  M  +  M  +  +  M  +  M  +  +  +  M  +  +  +  +  M  M  +|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Pars Distalis, Angiectasis           |                4                                3                       3|             
      Pars Distalis, Hyperplasia           |             3     1  1  3  2        1  1                                3|             
      Pars Intermedia, Hyperplasia         |                                                                          |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation                         |                                                                          |             
      Follicular Cell, Hyperplasia         | 1                          1                             1               |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Clitoral Gland                          | +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  M  M  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +|             
      Atrophy                              |                                           3                       2      |             
      Cyst                                 |    1                    2  1           2        2                    2   |             
      Germinal Epithelium, Hyperplasia     |                                              1                           |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                                                          |             
      Hydrometra                           |    3                                                        3            |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                                 2                        |             
                                            __________________________________________________________________________|             
   Lymph Node                              |                +        +                       +  +  +                  |             
      Angiectasis                          |                                                                          |             
      Pancreatic, Hyperplasia              |                                                    4                     |             
                                            __________________________________________________________________________|             
   Lymph Node, Bronchial                   | +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  M  +  +  +  +  M  M|             
      Hyperplasia                          |                                                             2            |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | M  +  M  M  +  +  +  +  +  M  +  +  +  +  +  +  M  +  +  M  M  +  +  +  +|             
      Hyperplasia                          |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hematopoietic Cell Proliferation     |                                                          2               |             
 _____________________________________________________________________________________________________________________|             

                                                             Page  11                                                               
NTP Experiment-Test: 05197-12                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          2-BUTOXYETHANOL                                      Date: 01/21/98  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 10:57:48  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 5| 7| 7| 6| 7| 6| 7| 7| 7| 3| 6| 7| 7| 7| 6| 5| 7| 7| 7| 4| 7| 7| 7|             
                             DAY ON TEST   | 3| 1| 3| 3| 3| 0| 3| 7| 3| 3| 3| 6| 0| 3| 1| 3| 7| 9| 3| 3| 3| 7| 3| 1| 3|             
                                           | 3| 2| 4| 1| 2| 4| 2| 0| 1| 1| 2| 9| 6| 2| 5| 3| 2| 2| 2| 3| 2| 2| 2| 2| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    62.5 PPM                               | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Hyperplasia                          |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mediastinal                 | M  +  +  +  M  +  +  M  +  +  +  M  +  +  M  +  +  +  +  +  +  +  +  +  M|             
      Hyperplasia                          |                                                                          |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hematopoietic Cell Proliferation     |             2  2     3  4  2     2  3     3  2  4  3  2  2        1  3   |             
      Hyperplasia, Lymphoid                | 2  4     1                                                        2      |             
      Pigmentation, Hemosiderin            | 2     2  2  1     2  1  1  2  2     2     1  2  1  2  2  2  2  2  2  2  2|             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  M  +  M  +  +  +  +  +  +  +  M  M  +  +  M  M  +  +  +  +  +  M  +|             
      Atrophy                              |    3                                                                     |             
      Hyperplasia, Lymphoid                |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                               1                          2               |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                                                                2         |             
      Necrosis                             |                                                                2         |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrous Osteodystrophy               | 2  1        1  1  1  1     4                 2     1        2           1|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic                |                                                                          |             
                                            __________________________________________________________________________|             
   Spinal Cord                             |                +                                                         |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Larynx                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Suppurative            |       1                             1              1                     |             
      Squamous Epithelium, Hyperplasia     |       1        1                    2              1                     |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           | 1                                                                        |             
      Infiltration Cellular, Histiocyte    |                                                                          |             
      Inflammation                         |                                           2                              |             
      Alveolar Epithelium, Hyperplasia     |                         1                                                |             
      Mediastinum, Inflammation            |                                                                          |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic Active         |                                                                          |             
      Inflammation, Suppurative            |                                                                          |             
      Olfactory Epithelium, Atrophy        |             1     1                                      1               |             
      Olfactory Epithelium, Degeneration,  |                                                                          |             
           Hyaline                         |                      1     1  2        1  2  1           1               |             
      Olfactory Epithelium, Metaplasia     |                                                                          |             
 _____________________________________________________________________________________________________________________|             

                                                             Page  12                                                               
NTP Experiment-Test: 05197-12                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          2-BUTOXYETHANOL                                      Date: 01/21/98  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 10:57:48  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 5| 7| 7| 6| 7| 6| 7| 7| 7| 3| 6| 7| 7| 7| 6| 5| 7| 7| 7| 4| 7| 7| 7|             
                             DAY ON TEST   | 3| 1| 3| 3| 3| 0| 3| 7| 3| 3| 3| 6| 0| 3| 1| 3| 7| 9| 3| 3| 3| 7| 3| 1| 3|             
                                           | 3| 2| 4| 1| 2| 4| 2| 0| 1| 1| 2| 9| 6| 2| 5| 3| 2| 2| 2| 3| 2| 2| 2| 2| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    62.5 PPM                               | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
      Respiratory Epithelium, Degeneration,|                                                                          |             
           Hyaline                         | 1              1  2  1  1  1  2     1  1  2  2        1  2     1  1  1  1|             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                                        +                                 |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Glomerulosclerosis                   |       1                                            2                     |             
      Inflammation, Chronic Active         |       1                                                                  |             
      Metaplasia, Osseous                  |                                                                          |             
      Nephropathy                          | 1  3  1  1  1  1  1  1     1  1           1  1  1  1  1  1  1  2  1  1  1|             
      Pigmentation, Hemosiderin            |    1                                                                     |             
      Renal Tubule, Hyperplasia            |                                     1                                    |             
      Renal Tubule, Mineralization         |    2                                                                     |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation                         |                                                                          |             
 _____________________________________________________________________________________________________________________|             

                                                             Page  13                                                               
NTP Experiment-Test: 05197-12                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          2-BUTOXYETHANOL                                      Date: 01/21/98  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 10:57:48  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 6| 7| 3| 7| 4| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 5| 7| 2| 6| 7| 7| 7|            |
                             DAY ON TEST   | 2| 3| 4| 3| 7| 3| 5| 3| 3| 3| 3| 3| 3| 7| 3| 3| 3| 3| 4| 3| 5| 9| 3| 3| 3|            |
                                           | 3| 3| 7| 1| 2| 1| 6| 2| 2| 1| 3| 2| 2| 6| 1| 2| 2| 1| 4| 2| 5| 4| 2| 1| 2|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|      A     |
    62.5 PPM                               | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Gallbladder                             | +  +  M  +  +  I  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M|  43        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Inflammation                         |                                                                          |      2  2.5|
      Necrosis                             |                                                                          |      1  4.0|
      Epithelium, Hyperplasia              |                4                                                         |      2  3.0|
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Angiectasis                          |                                                                          |      1  1.0|
      Clear Cell Focus                     |                                                                          |      1     |
      Degeneration, Fatty                  |                                                          1               |      1  1.0|
      Eosinophilic Focus                   |                                                                X        X|      6     |
      Hematopoietic Cell Proliferation     |       1           2                                                      |      7  1.6|
      Hyperplasia, Lymphoid                |                                           3                              |      1  3.0|
      Inflammation                         |                                           2     4              1         |      5  2.0|
      Necrosis                             |       1  1              1        1                                       |      8  1.4|
      Kupffer Cell, Pigmentation,          |                                                                          |            |
          Hemosiderin                      |                                                                1         |      5  1.0|
                                            __________________________________________________________________________|____________|
   Mesentery                               |                   +                                                     +|   4        |
      Fat, Necrosis                        |                   4                                                     2|      3  3.3|
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Atrophy                              |                                                 1              2  1      |      4  1.3|
      Cytoplasmic Alteration               |                                                                          |      2  1.0|
      Duct, Cyst                           |                                                                4         |      1  4.0|
      Duct, Inflammation                   |                                                                3         |      1  3.0|
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Ulcer                                | 1                                1  1                          1         |      7  1.3|
      Epithelium, Hyperplasia              | 1           1     2  1  2        2  2  2  3     3  1     2     2     1   |     27  2.0|
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inflammation, Suppurative            |                                                                2         |      1  2.0|
      Mineralization                       |                                                                          |      1  1.0|
      Ulcer                                |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Tooth                                   |             +                                                            |   1        |
      Inflammation                         |             4                                                            |      1  4.0|
 __________________________________________________________________________________________________________________________________ 

  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        

                                                             Page  14                                                               
NTP Experiment-Test: 05197-12                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          2-BUTOXYETHANOL                                      Date: 01/21/98  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 10:57:48  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 6| 7| 3| 7| 4| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 5| 7| 2| 6| 7| 7| 7|            |
                             DAY ON TEST   | 2| 3| 4| 3| 7| 3| 5| 3| 3| 3| 3| 3| 3| 7| 3| 3| 3| 3| 4| 3| 5| 9| 3| 3| 3|            |
                                           | 3| 3| 7| 1| 2| 1| 6| 2| 2| 1| 3| 2| 2| 6| 1| 2| 2| 1| 4| 2| 5| 4| 2| 1| 2|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|      A     |
    62.5 PPM                               | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
                                           |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood Vessel                            |                                                                          |   1        |
      Mineralization                       |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cardiomyopathy                       | 1  1  1  1     1  1  1  1  1  1  1  1  1  1  1  1  1     1     1  2  1  1|     45  1.1|
      Mineralization                       |                                                                          |      1  1.0|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hematopoietic Cell Proliferation     |                   4                                                      |      2  3.5|
      Hypertrophy                          |          1                                                               |      2  1.0|
                                            __________________________________________________________________________|____________|
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia                          |                                                    1                 1   |      3  1.0|
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +  +  +  M  M  +  M  +  M  +  +  +  +  M  +  M  +  +  +  M  +  +  +|  33        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  I  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Pars Distalis, Angiectasis           |                                     3                                    |      4  3.3|
      Pars Distalis, Hyperplasia           |                      1  3     4           4  3                 2  1      |     15  2.2|
      Pars Intermedia, Hyperplasia         |          1                                               2               |      2  1.5|
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inflammation                         |                                                 1                        |      1  1.0|
      Follicular Cell, Hyperplasia         |                      1     2        2           1                    2   |      8  1.4|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Clitoral Gland                          | +  +  +  +  +  +  M  +  +  +  M  +  +  +  +  +  +  +  +  +  M  M  +  +  +|  42        |
                                            __________________________________________________________________________|____________|
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Atrophy                              |                                                                          |      2  2.5|
      Cyst                                 | 1                                1        3        1     1        1      |     12  1.5|
      Germinal Epithelium, Hyperplasia     |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Angiectasis                          | 1                                   1           4                        |      3  2.0|
      Hydrometra                           |                                                                          |      2  3.0|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 __________________________________________________________________________________________________________________________________ 

  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        

                                                             Page  15                                                               
NTP Experiment-Test: 05197-12                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          2-BUTOXYETHANOL                                      Date: 01/21/98  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 10:57:48  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 6| 7| 3| 7| 4| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 5| 7| 2| 6| 7| 7| 7|            |
                             DAY ON TEST   | 2| 3| 4| 3| 7| 3| 5| 3| 3| 3| 3| 3| 3| 7| 3| 3| 3| 3| 4| 3| 5| 9| 3| 3| 3|            |
                                           | 3| 3| 7| 1| 2| 1| 6| 2| 2| 1| 3| 2| 2| 6| 1| 2| 2| 1| 4| 2| 5| 4| 2| 1| 2|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|      A     |
    62.5 PPM                               | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
      Hyperplasia                          |       2           2                                         2            |      4  2.0|
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +                                                        +               |   7        |
      Angiectasis                          |                                                          2               |      1  2.0|
      Pancreatic, Hyperplasia              |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Bronchial                   | +  +  +  +  M  +  M  +  M  +  +  +  +  +  +  +  +  M  +  +  M  M  M  +  +|  39        |
      Hyperplasia                          |       2                       3  2              2        2               |      6  2.2|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  M  M  +  +  M  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M|  38        |
      Hyperplasia                          |                                  2              3                        |      2  2.5|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  M  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Hematopoietic Cell Proliferation     |                                                                          |      1  2.0|
      Hyperplasia                          |                         2                       3                        |      2  2.5|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mediastinal                 | +  +  +  +  +  M  M  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M|  40        |
      Hyperplasia                          |       2                                         2                        |      2  2.0|
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hematopoietic Cell Proliferation     |    2  3  3        4           2     2  2  2  2  3        2  2  2        2|     29  2.4|
      Hyperplasia, Lymphoid                |    3                 1  1        1           2  3  2     4        2  3  2|     15  2.2|
      Pigmentation, Hemosiderin            |    2  2  2  2  1  2  2  2  2  2  2  2  2  2  2  2  2  2  2     1  2  2  2|     44  1.8|
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  M  +  +  +  +|  41        |
      Atrophy                              |       3                                                                  |      2  3.0|
      Hyperplasia, Lymphoid                |                                                          2        3      |      2  2.5|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia                          |                                                                          |      2  1.5|
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Atrophy                              |                                                                          |      1  2.0|
      Necrosis                             |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Fibrous Osteodystrophy               | 2  1  1  1     1     1     1  2  1  1     2  1     1     3        1  1  1|     28  1.4|
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inflammation, Chronic                |                                        2                                 |      1  2.0|
                                            __________________________________________________________________________|____________|
   Spinal Cord                             |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Larynx                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 __________________________________________________________________________________________________________________________________ 

  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        

                                                             Page  16                                                               
NTP Experiment-Test: 05197-12                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          2-BUTOXYETHANOL                                      Date: 01/21/98  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 10:57:48  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 6| 7| 3| 7| 4| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 5| 7| 2| 6| 7| 7| 7|            |
                             DAY ON TEST   | 2| 3| 4| 3| 7| 3| 5| 3| 3| 3| 3| 3| 3| 7| 3| 3| 3| 3| 4| 3| 5| 9| 3| 3| 3|            |
                                           | 3| 3| 7| 1| 2| 1| 6| 2| 2| 1| 3| 2| 2| 6| 1| 2| 2| 1| 4| 2| 5| 4| 2| 1| 2|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|      A     |
    62.5 PPM                               | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 __________________________________________________________________________________________________________________________________ 
 RESPIRATORY SYSTEM - cont                 |                                                                          |            |
                                           |                                                                          |            |
      Inflammation, Suppurative            |                                                                          |      3  1.0|
      Squamous Epithelium, Hyperplasia     |       1                                               1     2        1   |      8  1.3|
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hemorrhage                           |                                     1                                    |      2  1.0|
      Infiltration Cellular, Histiocyte    |                                                    2        1            |      2  1.5|
      Inflammation                         |                                                                          |      1  2.0|
      Alveolar Epithelium, Hyperplasia     |                                                                      3   |      2  2.0|
      Mediastinum, Inflammation            |                                        2                                 |      1  2.0|
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inflammation, Chronic Active         |                                                             4            |      1  4.0|
      Inflammation, Suppurative            | 1                                               1                    2   |      3  1.3|
      Olfactory Epithelium, Atrophy        |                                                             2            |      4  1.3|
      Olfactory Epithelium, Degeneration,  |                                                                          |            |
           Hyaline                         |          1           1  1  1     1                                1  1   |     14  1.1|
      Olfactory Epithelium, Metaplasia     |          1                                                               |      1  1.0|
      Respiratory Epithelium, Degeneration,|                                                                          |            |
           Hyaline                         |       1  1        1  1  2  2  1  1  1  1  1  1  1  1     1     1  2  2   |     35  1.3|
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Harderian Gland                         |    +     +                    +                                          |   4        |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Glomerulosclerosis                   |                                                                          |      2  1.5|
      Inflammation, Chronic Active         |                                                                          |      1  1.0|
      Metaplasia, Osseous                  |          1                                                               |      1  1.0|
      Nephropathy                          | 1        1     1  2  1  1  1  1  1  1  1  1  1  1  1  1              1  1|     39  1.1|
      Pigmentation, Hemosiderin            |                                                                          |      1  1.0|
      Renal Tubule, Hyperplasia            |                                                                          |      1  1.0|
      Renal Tubule, Mineralization         |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +|  49        |
      Inflammation                         |                                                 3                        |      1  3.0|
 __________________________________________________________________________________________________________________________________ 

  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        

                                                             Page  17                                                               
NTP Experiment-Test: 05197-12                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          2-BUTOXYETHANOL                                      Date: 01/21/98  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 10:57:48  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 5| 1| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 5| 7| 6| 7| 4| 5| 7| 7| 7| 7| 5| 3|             
                             DAY ON TEST   | 3| 4| 9| 3| 3| 9| 3| 3| 3| 1| 3| 2| 3| 7| 3| 2| 3| 5| 9| 3| 3| 3| 3| 3| 9|             
                                           | 2| 4| 6| 3| 2| 8| 1| 3| 1| 5| 2| 3| 1| 2| 1| 7| 1| 6| 1| 2| 2| 2| 3| 7| 7|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
    125 PPM                                | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Gallbladder                             | +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  A  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation                         |                   1                                                      |             
      Epithelium, Hyperplasia              |                   1                                                      |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Degeneration, Fatty                  |                                                                          |             
      Eosinophilic Focus                   |             X  X              X  X                    X              X   |             
      Hematopoietic Cell Proliferation     |                                                                          |             
      Infarct                              |                                                                          |             
      Inflammation                         |                               2           1                              |             
      Necrosis                             |                3  1     2                    1                       3   |             
      Thrombosis                           |                               3                                          |             
      Endothelial Cell, Hyperplasia        |                                           2                              |             
      Kupffer Cell, Pigmentation,          |                                                                          |             
          Hemosiderin                      |    1        1  1        1        1  1  2     1     1  1                  |             
                                            __________________________________________________________________________|             
   Mesentery                               |                +                                      +                  |             
      Fat, Necrosis                        |                                                       3                  |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |             1                                                            |             
      Hyperplasia, Lymphoid                |                                                                          |             
      Inflammation                         |                   1                                                      |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Ulcer                                |    1     1     1        3        1     2  1     1  2                    1|             
      Epithelium, Hyperplasia              | 2  2     2     2  2     4  2  4  2  2  3  1  2  3  3  1  2  1  2  2     2|             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Ulcer                                |                                                                      1   |             
      Epithelium, Hyperplasia              |          1                                                               |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood Vessel                            |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cardiomyopathy                       | 1  1     1  1  1  1  1  1  1  1  1  1        1  1  1  1  1  1  1  1  2   |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hypertrophy                          |                                     1        1           1               |             
      Capsule, Hyperplasia                 |          3                                                               |             
 _____________________________________________________________________________________________________________________|             

                                                             Page  18                                                               
NTP Experiment-Test: 05197-12                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          2-BUTOXYETHANOL                                      Date: 01/21/98  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 10:57:48  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 5| 1| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 5| 7| 6| 7| 4| 5| 7| 7| 7| 7| 5| 3|             
                             DAY ON TEST   | 3| 4| 9| 3| 3| 9| 3| 3| 3| 1| 3| 2| 3| 7| 3| 2| 3| 5| 9| 3| 3| 3| 3| 3| 9|             
                                           | 2| 4| 6| 3| 2| 8| 1| 3| 1| 5| 2| 3| 1| 2| 1| 7| 1| 6| 1| 2| 2| 2| 3| 7| 7|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
    125 PPM                                | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                                             1            |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  M  +  M  M  +  M  +  M  +  +  M  +  +  +  +|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M|             
      Pars Distalis, Hyperplasia           | 1  2     1     1     2              4                    1  1  2  2      |             
      Pars Intermedia, Hyperplasia         |    2                                                                     |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Follicular Cell, Hyperplasia         |          2     1     1  2  1  1                          1  1            |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Clitoral Gland                          | +  M  +  +  +  +  +  M  +  M  M  +  +  +  +  +  +  +  M  +  +  +  +  +  M|             
                                            __________________________________________________________________________|             
   Ovary                                   | M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                                                          |             
      Atrophy                              |                                  4                                   2   |             
      Cyst                                 |       4  2     1           2  2              3  4     2  1     2         |             
      Inflammation                         |                                                                          |             
      Thrombosis                           |                                                                          |             
      Germinal Epithelium, Hyperplasia     |                                     1                                    |             
      Interstitial Cell, Hyperplasia       |                                     1                                    |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                                                          |             
      Hydrometra                           |                                                                          |             
      Hyperplasia, Cystic                  |                                        4                                 |             
      Lymphangiectasis                     |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |    2                                                                     |             
                                            __________________________________________________________________________|             
   Lymph Node                              |                            +     +                                       |             
                                            __________________________________________________________________________|             
   Lymph Node, Bronchial                   | M  +  A  +  +  M  +  +  +  +  +  +  M  +  +  M  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                      2                    2                 2        2   |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  M  +  M  M  +  M  +  +  +  M  M  +  +  +  M  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                           2                              |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hematopoietic Cell Proliferation     |                                                                          |             
      Hyperplasia                          |                      4                    2                              |             
                                            __________________________________________________________________________|             
   Lymph Node, Mediastinal                 | +  +  +  +  +  M  M  +  +  +  +  M  +  +  +  +  +  +  M  M  M  M  +  +  M|             
      Hyperplasia, Lymphoid                |                                                                          |             
      Hyperplasia                          |                      2                                                   |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             

                                                             Page  19                                                               
NTP Experiment-Test: 05197-12                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          2-BUTOXYETHANOL                                      Date: 01/21/98  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 10:57:48  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 5| 1| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 5| 7| 6| 7| 4| 5| 7| 7| 7| 7| 5| 3|             
                             DAY ON TEST   | 3| 4| 9| 3| 3| 9| 3| 3| 3| 1| 3| 2| 3| 7| 3| 2| 3| 5| 9| 3| 3| 3| 3| 3| 9|             
                                           | 2| 4| 6| 3| 2| 8| 1| 3| 1| 5| 2| 3| 1| 2| 1| 7| 1| 6| 1| 2| 2| 2| 3| 7| 7|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
    125 PPM                                | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Hematopoietic Cell Proliferation     |    2     2     2     2  2     2        3  2  2  2     3     2        3   |             
      Hyperplasia, Lymphoid                | 2           2     2  2              2                                    |             
      Pigmentation, Hemosiderin            | 2  2     2  2  2  2  2  2  1  2  2  2  2  2  2  2  2  2  2  2  2  2  2   |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +|             
      Hyperplasia, Lymphoid                |                                     2                                    |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                                                          |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrous Osteodystrophy               | 1        1        1  2  1        1           1  1        4  1  1         |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |                                                                      2   |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Larynx                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Squamous Epithelium, Hyperplasia     |                                                                         1|             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |             2        1                                                   |             
      Infiltration Cellular, Histiocyte    |                                                             2            |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Suppurative            |                                  1                                       |             
      Olfactory Epithelium, Atrophy        |                                                                          |             
      Olfactory Epithelium, Degeneration,  |                                                                          |             
           Hyaline                         |             1                                   1        2        1      |             
      Respiratory Epithelium, Degeneration,|                                                                          |             
           Hyaline                         | 1        2  1  1  2        1  1     1           1        1        1      |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                         +                                                |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Glomerulosclerosis                   |    1     1                       2                 1  2                  |             
      Metaplasia, Osseous                  |             1                                                            |             
      Nephropathy                          | 1  1     2        1  1  1     1  2  1     1  1  1  1     1  1  1  1  1   |             
      Renal Tubule, Degeneration           |                1                                                         |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             

                                                             Page  20                                                               
NTP Experiment-Test: 05197-12                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          2-BUTOXYETHANOL                                      Date: 01/21/98  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 10:57:48  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 5| 7| 4| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 0| 7|            |
                             DAY ON TEST   | 3| 7| 3| 0| 2| 3| 3| 3| 2| 3| 3| 3| 3| 3| 3| 3| 6| 3| 3| 3| 3| 3| 3| 7| 3|            |
                                           | 1| 0| 3| 8| 3| 1| 2| 2| 3| 1| 1| 1| 3| 2| 2| 1| 6| 2| 3| 2| 1| 1| 3| 2| 2|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|      A     |
    125 PPM                                | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Gallbladder                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +|  46        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +|  48        |
      Inflammation                         |                                                                          |      1  1.0|
      Epithelium, Hyperplasia              |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +|  48        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +|  47        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +|  47        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +|  47        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +|  47        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Degeneration, Fatty                  |    1                                                                     |      1  1.0|
      Eosinophilic Focus                   | X     X                             X        X                           |     10     |
      Hematopoietic Cell Proliferation     |                                                                      1   |      1  1.0|
      Infarct                              |                                                                   4      |      1  4.0|
      Inflammation                         |                                        2           1                     |      4  1.5|
      Necrosis                             |             1                                                  1         |      7  1.7|
      Thrombosis                           |                                                                          |      1  3.0|
      Endothelial Cell, Hyperplasia        |                                                                          |      1  2.0|
      Kupffer Cell, Pigmentation,          |                                                                          |            |
          Hemosiderin                      | 1  1  1  1  1     1  1     1  1     1     1  1     1     1  1            |     25  1.0|
                                            __________________________________________________________________________|____________|
   Mesentery                               |                   +           +           +                              |   5        |
      Fat, Necrosis                        |                   2           2           2                              |      4  2.3|
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Atrophy                              |                                           1                              |      2  1.0|
      Hyperplasia, Lymphoid                |                                                          2               |      1  2.0|
      Inflammation                         |                                                    1           1         |      3  1.0|
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Ulcer                                |                               2     2              2                     |     13  1.5|
      Epithelium, Hyperplasia              | 1  4  2  1     1  2     1  4  3  4  4  3  2     2  4  2  4  2  4  3     1|     42  2.4|
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Ulcer                                |                                                                          |      1  1.0|
      Epithelium, Hyperplasia              |                                                                          |      1  1.0|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood Vessel                            |                                                 A                        |            |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cardiomyopathy                       | 1  1  2     2  1  1  1  1  1  1  1  1  1  1  1     1  1  1  2  1  1  1  1|     44  1.1|
 __________________________________________________________________________________________________________________________________ 

  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        

                                                             Page  21                                                               
NTP Experiment-Test: 05197-12                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          2-BUTOXYETHANOL                                      Date: 01/21/98  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 10:57:48  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 5| 7| 4| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 0| 7|            |
                             DAY ON TEST   | 3| 7| 3| 0| 2| 3| 3| 3| 2| 3| 3| 3| 3| 3| 3| 3| 6| 3| 3| 3| 3| 3| 3| 7| 3|            |
                                           | 1| 0| 3| 8| 3| 1| 2| 2| 3| 1| 1| 1| 3| 2| 2| 1| 6| 2| 3| 2| 1| 1| 3| 2| 2|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|      A     |
    125 PPM                                | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 __________________________________________________________________________________________________________________________________ 
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |            |
                                           |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hypertrophy                          |             1              1        1                                    |      6  1.0|
      Capsule, Hyperplasia                 |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +|  49        |
      Hyperplasia                          |                            1                       1                     |      3  1.0|
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  M  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  42        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Pars Distalis, Hyperplasia           |                         1  1              2  2              1           1|     16  1.6|
      Pars Intermedia, Hyperplasia         |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Follicular Cell, Hyperplasia         |                      1                             1  1                  |     11  1.2|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Clitoral Gland                          | +  +  +  M  +  +  M  +  +  M  +  +  M  +  M  +  +  +  +  +  +  +  +  M  +|  38        |
                                            __________________________________________________________________________|____________|
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Angiectasis                          |                               2                    2                     |      2  2.0|
      Atrophy                              |                                                                          |      2  3.0|
      Cyst                                 |    3              2                 3  2  4  2  1  4        2            |     19  2.4|
      Inflammation                         |                                                    3                     |      1  3.0|
      Thrombosis                           |                                           3        4                     |      2  3.5|
      Germinal Epithelium, Hyperplasia     |                                                                          |      1  1.0|
      Interstitial Cell, Hyperplasia       |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Angiectasis                          | 3                                                                        |      1  3.0|
      Hydrometra                           |                                                       3                  |      1  3.0|
      Hyperplasia, Cystic                  |                      2                                                   |      2  3.0|
      Lymphangiectasis                     |                                                       3                  |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia                          |                                                                      2   |      2  2.0|
                                            __________________________________________________________________________|____________|
   Lymph Node                              |    +                    +                 +                          +   |   6        |
                                            __________________________________________________________________________|____________|
   Lymph Node, Bronchial                   | +  +  +  M  +  +  M  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +|  41        |
 __________________________________________________________________________________________________________________________________ 

  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        

                                                             Page  22                                                               
NTP Experiment-Test: 05197-12                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          2-BUTOXYETHANOL                                      Date: 01/21/98  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 10:57:48  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 5| 7| 4| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 0| 7|            |
                             DAY ON TEST   | 3| 7| 3| 0| 2| 3| 3| 3| 2| 3| 3| 3| 3| 3| 3| 3| 6| 3| 3| 3| 3| 3| 3| 7| 3|            |
                                           | 1| 0| 3| 8| 3| 1| 2| 2| 3| 1| 1| 1| 3| 2| 2| 1| 6| 2| 3| 2| 1| 1| 3| 2| 2|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|      A     |
    125 PPM                                | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
      Hyperplasia                          |                                                                          |      4  2.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +  +  M  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +|  40        |
      Hyperplasia                          |                                                    3                     |      2  2.5|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Hematopoietic Cell Proliferation     |                      1                                                   |      1  1.0|
      Hyperplasia                          |                      2                                                   |      3  2.7|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mediastinal                 | +  +  M  M  +  +  +  +  +  M  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  38        |
      Hyperplasia, Lymphoid                |                                                                         4|      1  4.0|
      Hyperplasia                          |                      2           2                 3     2               |      5  2.2|
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Hematopoietic Cell Proliferation     |       2     2     2     3  2  3  2  2  2  2     2  3  1  2  2  3  2  3  2|     32  2.2|
      Hyperplasia, Lymphoid                | 2           4        2                 2           2     2              2|     12  2.2|
      Pigmentation, Hemosiderin            | 2     2  2  2  2  2  2  1  2  2  2  2  2  1  2  1  2  2  2  2  2  2     2|     46  1.9|
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  M  +|  46        |
      Hyperplasia, Lymphoid                |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia                          |       1                                                                  |      1  1.0|
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Fibrous Osteodystrophy               |             1  1  1  1     2     1  2  1  1           2     1  4  1     3|     25  1.5|
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hemorrhage                           |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Larynx                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Squamous Epithelium, Hyperplasia     |             1        2                                                   |      3  1.3|
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hemorrhage                           | 1  2                                2                                1   |      6  1.5|
      Infiltration Cellular, Histiocyte    |             2                    2                                       |      3  2.0|
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +|  49        |
      Inflammation, Suppurative            |                                                                          |      1  1.0|
      Olfactory Epithelium, Atrophy        |                                              2                    2      |      2  2.0|
      Olfactory Epithelium, Degeneration,  |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 

  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        

                                                             Page  23                                                               
NTP Experiment-Test: 05197-12                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          2-BUTOXYETHANOL                                      Date: 01/21/98  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 10:57:48  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 5| 7| 4| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 0| 7|            |
                             DAY ON TEST   | 3| 7| 3| 0| 2| 3| 3| 3| 2| 3| 3| 3| 3| 3| 3| 3| 6| 3| 3| 3| 3| 3| 3| 7| 3|            |
                                           | 1| 0| 3| 8| 3| 1| 2| 2| 3| 1| 1| 1| 3| 2| 2| 1| 6| 2| 3| 2| 1| 1| 3| 2| 2|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|      A     |
    125 PPM                                | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 __________________________________________________________________________________________________________________________________ 
 RESPIRATORY SYSTEM - cont                 |                                                                          |            |
                                           |                                                                          |            |
           Hyaline                         |                   2  1              1                    1  1  1  2      |     11  1.3|
      Respiratory Epithelium, Degeneration,|                                                                          |            |
           Hyaline                         | 1  2  2           1  1  1     1     1     1        2  1  1  1  1  2      |     26  1.2|
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Harderian Gland                         | +                                            +                           |   3        |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Glomerulosclerosis                   |    3     1  4                                                            |      8  1.9|
      Metaplasia, Osseous                  |                            1                                1            |      3  1.0|
      Nephropathy                          | 1  3  1     2  1  1  1     1  1  1  1  1     1     2  1  1  1  1  1     1|     38  1.2|
      Renal Tubule, Degeneration           |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +|  48        |
 __________________________________________________________________________________________________________________________________ 

  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        

                                                             Page  24                                                               
NTP Experiment-Test: 05197-12                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          2-BUTOXYETHANOL                                      Date: 01/21/98  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 10:57:48  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 4| 7| 7| 7| 6| 6| 7| 4| 5| 7| 7| 7| 6| 7| 7| 6| 7| 7| 7| 7| 7| 6| 7|             
                             DAY ON TEST   | 3| 3| 8| 3| 3| 3| 5| 8| 3| 3| 2| 3| 3| 3| 1| 3| 3| 2| 3| 3| 3| 3| 3| 6| 3|             
                                           | 1| 2| 5| 2| 2| 3| 3| 2| 1| 7| 9| 1| 1| 2| 8| 2| 1| 1| 3| 1| 2| 1| 1| 0| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
    250 PPM                                | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Gallbladder                             | +  +  +  +  +  +  A  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  A  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Epithelium, Hyperplasia              |       1                                                                  |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation                         |                                                                          |             
      Necrosis                             |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Peyer's Patch, Hyperplasia           |                                                          2               |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                     2                                    |             
      Basophilic Focus                     |                                                                          |             
      Clear Cell Focus                     |                                        X                                 |             
      Degeneration, Fatty                  |                                                             1            |             
      Eosinophilic Focus                   | X                                   X           X     X                  |             
      Hematopoietic Cell Proliferation     |                                                                          |             
      Inflammation                         |                                                    1     1               |             
      Necrosis                             |                               3                          2               |             
      Kupffer Cell, Pigmentation,          |                                                                          |             
          Hemosiderin                      |    1     1  1  1  2     1        1  1  1  1     1  1  1  1  1  1  1  1  1|             
                                            __________________________________________________________________________|             
   Mesentery                               |                               +        +  +                       +     +|             
      Fat, Necrosis                        |                               2        3  2                       2     2|             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |             1              1                             1     2         |             
      Cytoplasmic Alteration               |    1                                                                     |             
      Duct, Cyst                           |                                                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst Epithelial Inclusion            |                                                                          |             
      Ulcer                                | 2        1     1                    1                 2  1  1     1     2|             
      Epithelium, Hyperplasia              | 4  4  2  4  4  2  2     3  2  4  3  4  2  3  2  2  2  4  2     3  4  3  2|             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Ulcer                                |                                                                          |             
      Epithelium, Hyperplasia              |                                                                          |             
                                            __________________________________________________________________________|             
   Tongue                                  |                                                                          |             
      Epithelium, Hyperplasia              |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood Vessel                            |                                                                          |             
      Inflammation                         |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             

                                                             Page  25                                                               
NTP Experiment-Test: 05197-12                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          2-BUTOXYETHANOL                                      Date: 01/21/98  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 10:57:48  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 4| 7| 7| 7| 6| 6| 7| 4| 5| 7| 7| 7| 6| 7| 7| 6| 7| 7| 7| 7| 7| 6| 7|             
                             DAY ON TEST   | 3| 3| 8| 3| 3| 3| 5| 8| 3| 3| 2| 3| 3| 3| 1| 3| 3| 2| 3| 3| 3| 3| 3| 6| 3|             
                                           | 1| 2| 5| 2| 2| 3| 3| 2| 1| 7| 9| 1| 1| 2| 8| 2| 1| 1| 3| 1| 2| 1| 1| 0| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
    250 PPM                                | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |             
                                           |                                                                          |             
      Cardiomyopathy                       | 1  1  1  1  1  1     1  1        1  1  1     1  1  1  1  2  1  1  1  1  1|             
      Artery, Inflammation                 |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Degeneration, Cystic                 |                                                 3     2                  |             
      Hypertrophy                          |                         1        1                                       |             
                                            __________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |          1                                                  1            |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  M  +  M  +  +  M  +  M  M  +  M  +  +  +  M  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +|             
      Pars Distalis, Hyperplasia           | 4        2     2        2                    2  1  1                     |             
      Pars Intermedia, Hyperplasia         |                                                                          |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +|             
      Follicle, Cyst                       |    3                                                                     |             
      Follicular Cell, Hyperplasia         |                                        1     1  1              3         |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Clitoral Gland                          | +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                                                   2      |             
      Atrophy                              |                                                                          |             
      Cyst                                 | 4     4        1                          2  1        1     2            |             
      Degeneration, Fatty                  |                   4                                                      |             
      Infiltration Cellular, Mast Cell     |                                                                          |             
      Corpus Luteum, Hyperplasia           |                                                                          |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Adenomyosis                          |                                                                          |             
      Hydrometra                           |                         3                             4  3               |             
      Hyperplasia, Cystic                  |                                                                   3      |             
      Arteriole, Hyperplasia               |    4                                                                     |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrosis                             |          1                                                               |             
      Hyperplasia, Megakaryocyte           |                                                                          |             
      Hyperplasia                          |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node                              |                               +                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Bronchial                   | M  M  +  +  +  +  M  +  +  M  +  +  +  +  +  +  +  M  +  +  +  M  +  +  +|             
      Hyperplasia, Histiocytic             |                                                             2            |             
 _____________________________________________________________________________________________________________________|             

                                                             Page  26                                                               
NTP Experiment-Test: 05197-12                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          2-BUTOXYETHANOL                                      Date: 01/21/98  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 10:57:48  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 4| 7| 7| 7| 6| 6| 7| 4| 5| 7| 7| 7| 6| 7| 7| 6| 7| 7| 7| 7| 7| 6| 7|             
                             DAY ON TEST   | 3| 3| 8| 3| 3| 3| 5| 8| 3| 3| 2| 3| 3| 3| 1| 3| 3| 2| 3| 3| 3| 3| 3| 6| 3|             
                                           | 1| 2| 5| 2| 2| 3| 3| 2| 1| 7| 9| 1| 1| 2| 8| 2| 1| 1| 3| 1| 2| 1| 1| 0| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
    250 PPM                                | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | M  +  +  M  M  +  +  M  +  M  +  +  M  +  +  +  +  +  M  +  +  +  +  +  +|             
      Hyperplasia                          |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hematopoietic Cell Proliferation     |                                                                          |             
      Hyperplasia                          |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mediastinal                 | +  M  +  M  M  +  M  M  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  M|             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hematopoietic Cell Proliferation     |          2  2     2              1  3  2  2  2  2  3  2  3  2     2  2  2|             
      Hyperplasia, Lymphoid                |                2        2                             2                  |             
      Pigmentation, Hemosiderin            | 2  2  2  1  2  2  2  2  2        2  3  2  2  2  2  2  2  2  2  2  2  2  2|             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                      2                                               2   |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Arthrosis                            |                                                                          |             
      Fibrous Osteodystrophy               | 2     1           1     1           1  2     2  2                       1|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst Epithelial Inclusion            |                                                 X                        |             
      Hemorrhage                           |                               2                                          |             
      Meninges, Infiltration Cellular,     |                                                                          |             
           Mononuclear Cell                |                         1                                                |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Larynx                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +|             
      Inflammation, Suppurative            |                                                                          |             
      Squamous Epithelium, Hyperplasia     |                            1                                             |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |          1              1                    1                          1|             
      Infiltration Cellular, Histiocyte    |                                                                          |             
      Alveolar Epithelium, Hyperplasia     |                                                       1                  |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Olfactory Epithelium, Atrophy        |    2        1        2                                                   |             
      Olfactory Epithelium, Degeneration,  |                                                                          |             
           Hyaline                         | 1  1           2     1              1              1                    1|             
      Respiratory Epithelium, Degeneration,|                                                                          |             
           Hyaline                         |    1           1                    2  1     1              1        2  1|             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             

                                                             Page  27                                                               
NTP Experiment-Test: 05197-12                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          2-BUTOXYETHANOL                                      Date: 01/21/98  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 10:57:48  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 4| 7| 7| 7| 6| 6| 7| 4| 5| 7| 7| 7| 6| 7| 7| 6| 7| 7| 7| 7| 7| 6| 7|             
                             DAY ON TEST   | 3| 3| 8| 3| 3| 3| 5| 8| 3| 3| 2| 3| 3| 3| 1| 3| 3| 2| 3| 3| 3| 3| 3| 6| 3|             
                                           | 1| 2| 5| 2| 2| 3| 3| 2| 1| 7| 9| 1| 1| 2| 8| 2| 1| 1| 3| 1| 2| 1| 1| 0| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
    250 PPM                                | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                                                             +            |             
      Degeneration                         |                                                             4            |             
      Cornea, Inflammation, Chronic        |                                                                          |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                                                             +            |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Glomerulosclerosis                   | 2           1              1              1        3                     |             
      Metaplasia, Osseous                  |          1                                      2                        |             
      Nephropathy                          |    1     1  1     1                 1  1  1  1        1  1  1     1  1  1|             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             

                                                             Page  28                                                               
NTP Experiment-Test: 05197-12                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          2-BUTOXYETHANOL                                      Date: 01/21/98  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 10:57:48  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 6| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 4| 5| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7|            |
                             DAY ON TEST   | 3| 5| 3| 3| 3| 3| 0| 3| 8| 3| 3| 3| 3| 8| 8| 3| 3| 3| 3| 3| 3| 5| 3| 3| 3|            |
                                           | 2| 6| 1| 1| 2| 3| 8| 1| 2| 1| 3| 2| 2| 9| 2| 2| 3| 1| 1| 1| 3| 6| 1| 2| 2|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|      A     |
    250 PPM                                | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Gallbladder                             | +  +  +  +  +  +  +  +  +  +  +  +  M  A  +  +  +  +  +  +  +  +  +  +  +|  46        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +|  48        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +|  47        |
      Epithelium, Hyperplasia              |                                              1                           |      2  1.0|
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Inflammation                         |                   4                                                      |      1  4.0|
      Necrosis                             |                   4                                                      |      1  4.0|
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Peyer's Patch, Hyperplasia           |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Angiectasis                          |                                                       1                  |      2  1.5|
      Basophilic Focus                     |                                                    X                     |      1     |
      Clear Cell Focus                     |                                                                          |      1     |
      Degeneration, Fatty                  |                                                                          |      1  1.0|
      Eosinophilic Focus                   |                               X                                          |      5     |
      Hematopoietic Cell Proliferation     |                   4                                                      |      1  4.0|
      Inflammation                         |                      2                                                  1|      4  1.3|
      Necrosis                             |                         1                                                |      3  2.0|
      Kupffer Cell, Pigmentation,          |                                                                          |            |
          Hemosiderin                      | 1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1|     44  1.0|
                                            __________________________________________________________________________|____________|
   Mesentery                               |    +                                +              +           +         |   9        |
      Fat, Necrosis                        |    2                                2              2           2         |      9  2.1|
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Atrophy                              |                   4  1                                1                 4|      8  1.9|
      Cytoplasmic Alteration               |                                                                1         |      2  1.0|
      Duct, Cyst                           |                                                                         3|      1  3.0|
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cyst Epithelial Inclusion            |                X                                                         |      1     |
      Ulcer                                | 1     1  1  1                 2  1           2     1  2  3     1  1  2   |     22  1.4|
      Epithelium, Hyperplasia              | 3  3  3  3  3     2  2     4  4  2  2     1  4  2  3  4  4     3  3  4  2|     44  2.9|
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Ulcer                                |                   1                                                      |      1  1.0|
      Epithelium, Hyperplasia              |                                                             1            |      1  1.0|
                                            __________________________________________________________________________|____________|
   Tongue                                  |                               +                                          |   1        |
      Epithelium, Hyperplasia              |                               3                                          |      1  3.0|
 __________________________________________________________________________________________________________________________________ 

  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        

                                                             Page  29                                                               
NTP Experiment-Test: 05197-12                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          2-BUTOXYETHANOL                                      Date: 01/21/98  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 10:57:48  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 6| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 4| 5| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7|            |
                             DAY ON TEST   | 3| 5| 3| 3| 3| 3| 0| 3| 8| 3| 3| 3| 3| 8| 8| 3| 3| 3| 3| 3| 3| 5| 3| 3| 3|            |
                                           | 2| 6| 1| 1| 2| 3| 8| 1| 2| 1| 3| 2| 2| 9| 2| 2| 3| 1| 1| 1| 3| 6| 1| 2| 2|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|      A     |
    250 PPM                                | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
                                           |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood Vessel                            |                         +                    +                           |   2        |
      Inflammation                         |                         3                                                |      1  3.0|
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cardiomyopathy                       | 1  1  1  1  1  1  2  1     2  1  1  1  1  1  1  1  2  1  1  1  1  1  1  1|     45  1.1|
      Artery, Inflammation                 |                         2                                                |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Degeneration, Cystic                 |                                                                          |      2  2.5|
      Hypertrophy                          |          1                                               1           1   |      5  1.0|
                                            __________________________________________________________________________|____________|
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia                          |                                                                          |      2  1.0|
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  M  M  +  +  +  +  +  +|  40        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Pars Distalis, Hyperplasia           | 2  2     2  4     2  3        3  2  1        1     2                 2  2|     20  2.1|
      Pars Intermedia, Hyperplasia         |                                                                      2   |      1  2.0|
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Follicle, Cyst                       |                                                                          |      1  3.0|
      Follicular Cell, Hyperplasia         | 1              1     1        1  1  1              1                     |     11  1.2|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Clitoral Gland                          | +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  47        |
                                            __________________________________________________________________________|____________|
   Ovary                                   | +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Angiectasis                          |                                                                          |      1  2.0|
      Atrophy                              |                   3                                                      |      1  3.0|
      Cyst                                 | 1  1  1        2        3                       4  1     2  4            |     16  2.1|
      Degeneration, Fatty                  |                                                                          |      1  4.0|
      Infiltration Cellular, Mast Cell     |                                                                      2   |      1  2.0|
      Corpus Luteum, Hyperplasia           |                                                                      4   |      1  4.0|
                                            __________________________________________________________________________|____________|
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Adenomyosis                          |                                  2                                       |      1  2.0|
      Hydrometra                           |                                                                          |      3  3.3|
      Hyperplasia, Cystic                  |          4     4        4                                   4           3|      6  3.7|
 __________________________________________________________________________________________________________________________________ 

  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        

                                                             Page  30                                                               
NTP Experiment-Test: 05197-12                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          2-BUTOXYETHANOL                                      Date: 01/21/98  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 10:57:48  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 6| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 4| 5| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7|            |
                             DAY ON TEST   | 3| 5| 3| 3| 3| 3| 0| 3| 8| 3| 3| 3| 3| 8| 8| 3| 3| 3| 3| 3| 3| 5| 3| 3| 3|            |
                                           | 2| 6| 1| 1| 2| 3| 8| 1| 2| 1| 3| 2| 2| 9| 2| 2| 3| 1| 1| 1| 3| 6| 1| 2| 2|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|      A     |
    250 PPM                                | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 __________________________________________________________________________________________________________________________________ 
 GENITAL SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
      Arteriole, Hyperplasia               |                                                                          |      1  4.0|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Fibrosis                             |                                                                          |      1  1.0|
      Hyperplasia, Megakaryocyte           |                                           2                              |      1  2.0|
      Hyperplasia                          |                   2  1                                2                  |      3  1.7|
                                            __________________________________________________________________________|____________|
   Lymph Node                              |                                                                          |   1        |
                                            __________________________________________________________________________|____________|
   Lymph Node, Bronchial                   | +  +  +  +  M  +  +  M  +  M  +  +  +  +  M  +  M  M  +  +  +  +  M  +  +|  37        |
      Hyperplasia, Histiocytic             |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  M  +  M  +  +  +  +  +  +  M  M  M  +  +  +  +|  38        |
      Hyperplasia                          |                   2                                                      |      1  2.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hematopoietic Cell Proliferation     |                   2                                                      |      1  2.0|
      Hyperplasia                          |    2  2           2                                                      |      3  2.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mediastinal                 | +  +  M  +  M  M  +  M  +  M  M  +  +  +  +  +  +  M  +  M  +  +  +  +  M|  34        |
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hematopoietic Cell Proliferation     | 2  2  2  2  2     4     3  1  2  2     2  3     2  2  2     2  2  2  2   |     35  2.1|
      Hyperplasia, Lymphoid                |    4  3        2                    4        1              2           2|     10  2.4|
      Pigmentation, Hemosiderin            | 2  1  2  2  2  2  2  2  2  2  2  2  2  2  2  2  2  2  2  2  2  2  2  2  2|     48  2.0|
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia                          |                                                                          |      2  2.0|
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Arthrosis                            |                                                    3                     |      1  3.0|
      Fibrous Osteodystrophy               |    2  1  1  2        1                          2  2     1  1  1  1     1|     21  1.4|
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cyst Epithelial Inclusion            |                                                                          |      1     |
      Hemorrhage                           |                                                                          |      1  2.0|
      Meninges, Infiltration Cellular,     |                                                                          |            |
           Mononuclear Cell                |                                                       2                  |      2  1.5|
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 

  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        

                                                             Page  31                                                               
NTP Experiment-Test: 05197-12                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          2-BUTOXYETHANOL                                      Date: 01/21/98  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 10:57:48  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 6| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 4| 5| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7|            |
                             DAY ON TEST   | 3| 5| 3| 3| 3| 3| 0| 3| 8| 3| 3| 3| 3| 8| 8| 3| 3| 3| 3| 3| 3| 5| 3| 3| 3|            |
                                           | 2| 6| 1| 1| 2| 3| 8| 1| 2| 1| 3| 2| 2| 9| 2| 2| 3| 1| 1| 1| 3| 6| 1| 2| 2|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|      A     |
    250 PPM                                | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 __________________________________________________________________________________________________________________________________ 
 RESPIRATORY SYSTEM - cont                 |                                                                          |            |
                                           |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Larynx                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Inflammation, Suppurative            |                                        1                                 |      1  1.0|
      Squamous Epithelium, Hyperplasia     |    1        1                          2                          1      |      5  1.2|
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hemorrhage                           |       1        1                                                         |      6  1.0|
      Infiltration Cellular, Histiocyte    |             1                                                     2      |      2  1.5|
      Alveolar Epithelium, Hyperplasia     |             1                                                            |      2  1.0|
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Olfactory Epithelium, Atrophy        |             1                                                            |      4  1.5|
      Olfactory Epithelium, Degeneration,  |                                                                          |            |
           Hyaline                         |       1  1     1                    1                                   2|     12  1.2|
      Respiratory Epithelium, Degeneration,|                                                                          |            |
           Hyaline                         | 2     1  1     1     1     1  1     1     1  1     1  1           1  1  1|     23  1.1|
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Eye                                     |    +                                                           +  +      |   4        |
      Degeneration                         |                                                                          |      1  4.0|
      Cornea, Inflammation, Chronic        |    4                                                           2  4      |      3  3.3|
                                            __________________________________________________________________________|____________|
   Harderian Gland                         |    +                                                           +  +      |   4        |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Glomerulosclerosis                   |                         1              2  2                              |      8  1.6|
      Metaplasia, Osseous                  |                                                       1           1      |      4  1.3|
      Nephropathy                          | 1  1  1  1  1  1        1     1     1     1  1     1  1  1  1  1  1  1  1|     33  1.0|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 __________________________________________________________________________________________________________________________________ 

  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        

                                                             Page  32                                                               
NTP Experiment-Test: 05197-12                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          2-BUTOXYETHANOL                                      Date: 01/21/98  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 10:57:48  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 4| 6| 7| 6| 5| 7| 7| 7| 5| 7| 7| 7|             
                             DAY ON TEST   | 3| 2| 3| 3| 2| 2| 2| 3| 3| 1| 3| 2| 3| 5| 6| 3| 6| 6| 2| 3| 3| 6| 3| 2| 2|             
                                           | 0| 9| 1| 0| 9| 9| 9| 0| 0| 8| 0| 9| 0| 9| 7| 1| 9| 1| 9| 0| 0| 5| 0| 9| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    CONTROL                                | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Gallbladder                             | +  +  +  +  +  +  +  +  M  +  +  +  +  M  +  +  M  M  +  +  +  +  +  +  M|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Peyer's Patch, Hyperplasia           |                                     4                                    |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Peyer's Patch, Hyperplasia           |       3                                                                  |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation                         |                                                                          |             
      Peyer's Patch, Hyperplasia           |       2                                                                  |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Clear Cell Focus                     |       X                          X                                       |             
      Degeneration, Fatty                  |                                                                          |             
      Eosinophilic Focus                   |             X        X  X              X        X     X     X     X      |             
      Hematopoietic Cell Proliferation     |                                                                          |             
      Inflammation                         |       1        2                             2  1                        |             
      Karyomegaly                          |       1                                      3                           |             
      Necrosis                             |       1                                         1                        |             
      Oval Cell, Hyperplasia               |                                              2                           |             
                                            __________________________________________________________________________|             
   Mesentery                               |                   +                 +                                    |             
      Fat, Necrosis                        |                   3                 2                                    |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |       1        1     1                                      1            |             
      Cytoplasmic Alteration               |                1                                                         |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |    2                                                                     |             
      Ulcer                                |                                        1                                 |             
      Epithelium, Hyperplasia              |                                        3                                 |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Suppurative            |                                                          2               |             
      Mineralization                       |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cardiomyopathy                       | 1  1  2  1  1  1  2  2  2  1  2  2  1  1  2  1  1  2  2  1  1  2  1  1  1|             
      Artery, Inflammation                 |                                                                          |             
      Atrium, Thrombosis                   |                                           3                              |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Degeneration, Cystic                 |             2                                                            |             
 _____________________________________________________________________________________________________________________|             

                                                             Page  33                                                               
NTP Experiment-Test: 05197-12                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          2-BUTOXYETHANOL                                      Date: 01/21/98  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 10:57:48  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 4| 6| 7| 6| 5| 7| 7| 7| 5| 7| 7| 7|             
                             DAY ON TEST   | 3| 2| 3| 3| 2| 2| 2| 3| 3| 1| 3| 2| 3| 5| 6| 3| 6| 6| 2| 3| 3| 6| 3| 2| 2|             
                                           | 0| 9| 1| 0| 9| 9| 9| 0| 0| 8| 0| 9| 0| 9| 7| 1| 9| 1| 9| 0| 0| 5| 0| 9| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    CONTROL                                | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
      Hematopoietic Cell Proliferation     |                                                                          |             
      Hyperplasia                          |    3  2                       1                          2               |             
      Hypertrophy                          | 2  2     1  1  2  2     2     1  1        3  1  1  1  2  2  1     2  1  2|             
      Capsule, Hyperplasia                 |    3     2                                                               |             
                                            __________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                                                4         |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                         1                          2                     |             
      Inflammation                         |                                                 2                        |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | M  +  +  +  M  +  +  +  M  +  M  M  M  M  M  M  +  +  +  +  +  M  M  +  M|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +|             
      Pars Distalis, Cyst                  |                                                                   4      |             
      Pars Distalis, Hyperplasia           |                                              3  1           1            |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Follicular Cell, Hyperplasia         |                         1                                                |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation                         |       1                                               3                  |             
                                            __________________________________________________________________________|             
   Preputial Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +|             
      Ectasia                              |                                                                          |             
      Inflammation                         |                            1                                             |             
                                            __________________________________________________________________________|             
   Prostate                                | +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation                         |                      4                                                   |             
                                            __________________________________________________________________________|             
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              | 1                                         2     2                    1   |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Lymph Node                              |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Bronchial                   | +  +  M  +  +  M  +  +  +  +  +  +  +  +  M  +  M  +  +  M  +  +  M  +  +|             
      Hyperplasia                          |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  M  +  +  M  M  M  +  M  M  M  M  +  +  M  M  M  +  M  +  M  +  +  M|             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Amyloid Deposition                   |                                                                          |             
      Angiectasis                          |                                                                          |             
      Hematopoietic Cell Proliferation     |       2                                                                  |             
      Hyperplasia                          |       3     2                    2                                       |             
                                            __________________________________________________________________________|             
   Lymph Node, Mediastinal                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             

                                                             Page  34                                                               
NTP Experiment-Test: 05197-12                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          2-BUTOXYETHANOL                                      Date: 01/21/98  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 10:57:48  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 4| 6| 7| 6| 5| 7| 7| 7| 5| 7| 7| 7|             
                             DAY ON TEST   | 3| 2| 3| 3| 2| 2| 2| 3| 3| 1| 3| 2| 3| 5| 6| 3| 6| 6| 2| 3| 3| 6| 3| 2| 2|             
                                           | 0| 9| 1| 0| 9| 9| 9| 0| 0| 8| 0| 9| 0| 9| 7| 1| 9| 1| 9| 0| 0| 5| 0| 9| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    CONTROL                                | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Hematopoietic Cell Proliferation     |                2     3     2           1  2        1           2     2   |             
      Hyperplasia, Lymphoid                |    2  4                                                           2     2|             
                                            __________________________________________________________________________|             
   Thymus                                  | M  +  +  +  +  +  +  +  +  +  +  M  +  +  M  +  M  +  +  +  +  +  +  +  +|             
      Atrophy                              |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M|             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Prepuce, Inflammation, Chronic Active|                                  3                                       |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrous Osteodystrophy               |                                                                          |             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic                | 3                                                                        |             
      Necrosis                             |                                        1                                 |             
      Meninges, Infiltration Cellular,     |                                                                          |             
           Mononuclear Cell                |                               2                                          |             
                                            __________________________________________________________________________|             
   Spinal Cord                             |                                              +                           |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Larynx                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |          1              1                                                |             
      Infiltration Cellular, Histiocyte    |                2                          3                          2  2|             
      Inflammation, Chronic                |                                                                          |             
      Pigmentation, Hemosiderin            |                                                                          |             
      Alveolar Epithelium, Hyperplasia     |       4                                               2     2           2|             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Suppurative            |                                                 3                        |             
      Olfactory Epithelium, Atrophy        |          1                                            1                  |             
      Olfactory Epithelium, Degeneration,  |                                                                          |             
           Hyaline                         |                                                                          |             
      Respiratory Epithelium, Degeneration,|                                                                          |             
           Hyaline                         |             1                    1                                       |             
                                            __________________________________________________________________________|             
   Pleura                                  |                               +                                          |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ear                                     |          +                                                               |             
      Inflammation, Granulomatous          |          4                                                               |             
 _____________________________________________________________________________________________________________________|             

                                                             Page  35                                                               
NTP Experiment-Test: 05197-12                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          2-BUTOXYETHANOL                                      Date: 01/21/98  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 10:57:48  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 4| 6| 7| 6| 5| 7| 7| 7| 5| 7| 7| 7|             
                             DAY ON TEST   | 3| 2| 3| 3| 2| 2| 2| 3| 3| 1| 3| 2| 3| 5| 6| 3| 6| 6| 2| 3| 3| 6| 3| 2| 2|             
                                           | 0| 9| 1| 0| 9| 9| 9| 0| 0| 8| 0| 9| 0| 9| 7| 1| 9| 1| 9| 0| 0| 5| 0| 9| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    CONTROL                                | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM - cont              |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                                                                          |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                +                                                         |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Glomerulosclerosis                   |                   1        1                       1           2         |             
      Hydronephrosis                       |                                                                2         |             
      Mineralization                       |                1                                                         |             
      Nephropathy                          | 1  2  2  2  2  2  1  1  1  2  2  1  2  1  3  1  1  2  1  1  1  3  2  1  1|             
      Cortex, Cyst                         |                                                                          |             
      Renal Tubule, Hyperplasia            |                         1                                                |             
      Renal Tubule, Mineralization         |    1     1  1                                                            |             
      Renal Tubule, Necrosis               |                                                                          |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             

                                                             Page  36                                                               
NTP Experiment-Test: 05197-12                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          2-BUTOXYETHANOL                                      Date: 01/21/98  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 10:57:48  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 6| 6| 7| 3| 7| 7| 7| 7| 7| 7| 7| 5|            |
                             DAY ON TEST   | 3| 3| 3| 3| 3| 2| 2| 4| 3| 2| 2| 3| 2| 6| 2| 2| 7| 2| 3| 2| 2| 3| 3| 3| 5|            |
                                           | 0| 0| 0| 0| 0| 9| 9| 2| 0| 9| 9| 0| 9| 3| 1| 9| 4| 9| 0| 9| 9| 0| 0| 0| 6|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      A     |
    CONTROL                                | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Gallbladder                             | +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  M  +  +  +  +  +  +  M  +|  42        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  A|  48        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A|  49        |
      Peyer's Patch, Hyperplasia           |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  A|  48        |
      Peyer's Patch, Hyperplasia           |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Inflammation                         |                               2                                          |      1  2.0|
      Peyer's Patch, Hyperplasia           |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Clear Cell Focus                     |       X                             X                                    |      4     |
      Degeneration, Fatty                  |                                                       2                  |      1  2.0|
      Eosinophilic Focus                   |       X  X  X              X        X                          X         |     14     |
      Hematopoietic Cell Proliferation     |                                           1                              |      1  1.0|
      Inflammation                         |                   2                                               3      |      6  1.8|
      Karyomegaly                          |                                                                          |      2  2.0|
      Necrosis                             |                   2                    3     1                    4      |      6  2.0|
      Oval Cell, Hyperplasia               |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Mesentery                               |                         +        +                                   +   |   5        |
      Fat, Necrosis                        |                         2        2                                   2   |      5  2.2|
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Atrophy                              | 1        1  1        1  1                                      1         |     10  1.0|
      Cytoplasmic Alteration               |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cyst                                 |                                                                          |      1  2.0|
      Ulcer                                |                                                                          |      1  1.0|
      Epithelium, Hyperplasia              |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inflammation, Suppurative            |                                                                          |      1  2.0|
      Mineralization                       |                1                                                         |      1  1.0|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cardiomyopathy                       | 1  1  1  1  1  2  1     1  1  1  1  1  1  1  2     1  1  1  2  2  1  1   |     47  1.3|
      Artery, Inflammation                 |                         2                                                |      1  2.0|
 __________________________________________________________________________________________________________________________________ 

  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        

                                                             Page  37                                                               
NTP Experiment-Test: 05197-12                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          2-BUTOXYETHANOL                                      Date: 01/21/98  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 10:57:48  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 6| 6| 7| 3| 7| 7| 7| 7| 7| 7| 7| 5|            |
                             DAY ON TEST   | 3| 3| 3| 3| 3| 2| 2| 4| 3| 2| 2| 3| 2| 6| 2| 2| 7| 2| 3| 2| 2| 3| 3| 3| 5|            |
                                           | 0| 0| 0| 0| 0| 9| 9| 2| 0| 9| 9| 0| 9| 3| 1| 9| 4| 9| 0| 9| 9| 0| 0| 0| 6|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      A     |
    CONTROL                                | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 __________________________________________________________________________________________________________________________________ 
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |            |
                                           |                                                                          |            |
      Atrium, Thrombosis                   |                                                                          |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Degeneration, Cystic                 |                                                                          |      1  2.0|
      Hematopoietic Cell Proliferation     |                                        1                                 |      1  1.0|
      Hyperplasia                          |                                                             2            |      5  2.0|
      Hypertrophy                          | 2     2  1  1  1  1     1  1  3  1  2              1  2  1  1  1  1  1  1|     38  1.4|
      Capsule, Hyperplasia                 |                                                                          |      2  2.5|
                                            __________________________________________________________________________|____________|
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Hyperplasia                          |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia                          |                   4                 1              4           2         |      6  2.3|
      Inflammation                         |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | M  M  +  M  +  M  +  M  +  M  +  M  +  +  M  M  +  M  M  +  M  +  +  +  +|  26        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Pars Distalis, Cyst                  |                                                                          |      1  4.0|
      Pars Distalis, Hyperplasia           |    1                             1                                       |      5  1.4|
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Follicular Cell, Hyperplasia         |          1                 1     1                          1            |      5  1.0|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inflammation                         |                                     1                          1         |      4  1.5|
                                            __________________________________________________________________________|____________|
   Preputial Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Ectasia                              |                      2                                                   |      1  2.0|
      Inflammation                         |                                  1                                       |      2  1.0|
                                            __________________________________________________________________________|____________|
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inflammation                         |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Atrophy                              |                                                                1         |      5  1.4|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Lymph Node                              |                      +                    +                              |   2        |
 __________________________________________________________________________________________________________________________________ 

  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        

                                                             Page  38                                                               
NTP Experiment-Test: 05197-12                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          2-BUTOXYETHANOL                                      Date: 01/21/98  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 10:57:48  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 6| 6| 7| 3| 7| 7| 7| 7| 7| 7| 7| 5|            |
                             DAY ON TEST   | 3| 3| 3| 3| 3| 2| 2| 4| 3| 2| 2| 3| 2| 6| 2| 2| 7| 2| 3| 2| 2| 3| 3| 3| 5|            |
                                           | 0| 0| 0| 0| 0| 9| 9| 2| 0| 9| 9| 0| 9| 3| 1| 9| 4| 9| 0| 9| 9| 0| 0| 0| 6|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      A     |
    CONTROL                                | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lymph Node, Bronchial                   | M  M  +  +  M  +  +  +  +  +  +  M  M  +  +  +  +  M  +  +  +  +  +  +  +|  38        |
      Hyperplasia                          |                   2                          2                           |      2  2.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | M  M  +  M  M  +  +  +  M  M  +  M  +  +  +  +  M  M  M  +  M  +  +  +  M|  24        |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Amyloid Deposition                   |                            1                                             |      1  1.0|
      Angiectasis                          |                      2                             1                     |      2  1.5|
      Hematopoietic Cell Proliferation     |                                                                          |      1  2.0|
      Hyperplasia                          |       2                    2                 2                    2      |      7  2.1|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mediastinal                 | M  M  +  +  M  +  +  M  +  M  +  +  +  +  +  M  +  M  M  +  M  +  +  +  +|  40        |
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hematopoietic Cell Proliferation     |       1           2                    2                          2      |     12  1.8|
      Hyperplasia, Lymphoid                |             2                                                            |      5  2.4|
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  M  +  +  +  +  +  M|  43        |
      Atrophy                              |                      3                                                   |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M|            |
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Prepuce, Inflammation, Chronic Active|                                                                   4      |      2  3.5|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Fibrous Osteodystrophy               |    2                                                                     |      1  2.0|
                                            __________________________________________________________________________|____________|
   Skeletal Muscle                         |                                                                         +|   1        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inflammation, Chronic                |                                                                          |      1  3.0|
      Necrosis                             |                                                                          |      1  1.0|
      Meninges, Infiltration Cellular,     |                                                                          |            |
           Mononuclear Cell                |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Spinal Cord                             |                      +                                                   |   2        |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Larynx                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hemorrhage                           |          1                          1                                   1|      5  1.0|
      Infiltration Cellular, Histiocyte    |                                              3                       2   |      6  2.3|
      Inflammation, Chronic                |                                                                      2   |      1  2.0|
 __________________________________________________________________________________________________________________________________ 

  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        

                                                             Page  39                                                               
NTP Experiment-Test: 05197-12                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          2-BUTOXYETHANOL                                      Date: 01/21/98  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 10:57:48  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 6| 6| 7| 3| 7| 7| 7| 7| 7| 7| 7| 5|            |
                             DAY ON TEST   | 3| 3| 3| 3| 3| 2| 2| 4| 3| 2| 2| 3| 2| 6| 2| 2| 7| 2| 3| 2| 2| 3| 3| 3| 5|            |
                                           | 0| 0| 0| 0| 0| 9| 9| 2| 0| 9| 9| 0| 9| 3| 1| 9| 4| 9| 0| 9| 9| 0| 0| 0| 6|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      A     |
    CONTROL                                | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 __________________________________________________________________________________________________________________________________ 
 RESPIRATORY SYSTEM - cont                 |                                                                          |            |
                                           |                                                                          |            |
      Pigmentation, Hemosiderin            |                                                                      1   |      1  1.0|
      Alveolar Epithelium, Hyperplasia     |          2                                                           2   |      6  2.3|
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inflammation, Suppurative            |                            2                                             |      2  2.5|
      Olfactory Epithelium, Atrophy        |                      3                                1                  |      4  1.5|
      Olfactory Epithelium, Degeneration,  |                                                                          |            |
           Hyaline                         |       1                                                                  |      1  1.0|
      Respiratory Epithelium, Degeneration,|                                                                          |            |
           Hyaline                         |             1              1                                             |      4  1.0|
                                            __________________________________________________________________________|____________|
   Pleura                                  |                                                                          |   1        |
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Ear                                     |                                                                          |   1        |
      Inflammation, Granulomatous          |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Eye                                     | +                                                                        |   1        |
                                            __________________________________________________________________________|____________|
   Harderian Gland                         | +                                                     +                  |   3        |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Glomerulosclerosis                   |                                                                          |      4  1.3|
      Hydronephrosis                       |                                                                          |      1  2.0|
      Mineralization                       |                                                                          |      1  1.0|
      Nephropathy                          | 1  1  2  2  1  1  1  1  2  1  1  1     1     1  1  1  1  1  2  1  1  1  1|     48  1.4|
      Cortex, Cyst                         |             2     2                          1                 2         |      4  1.8|
      Renal Tubule, Hyperplasia            |                                     1                                    |      2  1.0|
      Renal Tubule, Mineralization         |                                                                         1|      4  1.0|
      Renal Tubule, Necrosis               |                                                                         1|      1  1.0|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 __________________________________________________________________________________________________________________________________ 

  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        

                                                             Page  40                                                               
NTP Experiment-Test: 05197-12                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          2-BUTOXYETHANOL                                      Date: 01/21/98  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 10:57:48  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 6| 7| 7| 6| 5| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 3| 2| 3| 2| 3| 2| 5| 3| 2| 3| 4| 3| 3| 8| 4| 1| 3| 2| 2| 3| 3| 3| 2| 2| 2|             
                                           | 0| 9| 0| 9| 0| 9| 6| 0| 9| 1| 9| 0| 0| 1| 9| 1| 0| 9| 9| 1| 0| 0| 9| 9| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    62.5 PPM                               | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Gallbladder                             | +  +  +  +  +  +  +  +  +  +  M  +  +  M  A  +  +  +  +  +  +  +  +  +  +|             
      Degeneration, Hyaline                |                                                                          |             
      Inflammation                         |                                                                2         |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +|             
      Peyer's Patch, Hyperplasia           |                                                 2                        |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Degeneration, Fatty                  |                                     1                                    |             
      Eosinophilic Focus                   |          X  X                                               X           X|             
      Hematopoietic Cell Proliferation     |                                                                      1   |             
      Infarct                              |                                                                          |             
      Inflammation                         |                                                                      1   |             
      Necrosis                             |                                              3                           |             
      Oval Cell, Hyperplasia               |                                        2                                 |             
                                            __________________________________________________________________________|             
   Mesentery                               |    +     +                                                               |             
      Angiectasis                          |    3                                                                     |             
      Fat, Necrosis                        |          2                                                               |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |       1                                               1        1         |             
      Degeneration, Hyaline                |                                        2                                 |             
      Inflammation                         |                                                                          |             
      Duct, Cyst                           |                                                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation                         |                            1                                             |             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Ulcer                                |                                                                      2   |             
      Epithelium, Hyperplasia              |                                                                      3   |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Mineralization                       |                1                                                         |             
      Ulcer                                |                                                                          |             
                                            __________________________________________________________________________|             
   Tooth                                   |                                                                          |             
      Malformation                         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cardiomyopathy                       | 1  1  1  1  1  1  2  1  1  1  2  1  1  2     1  1  1  1  1  1  1  1  2  1|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             

                                                             Page  41                                                               
NTP Experiment-Test: 05197-12                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          2-BUTOXYETHANOL                                      Date: 01/21/98  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 10:57:48  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 6| 7| 7| 6| 5| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 3| 2| 3| 2| 3| 2| 5| 3| 2| 3| 4| 3| 3| 8| 4| 1| 3| 2| 2| 3| 3| 3| 2| 2| 2|             
                                           | 0| 9| 0| 9| 0| 9| 6| 0| 9| 1| 9| 0| 0| 1| 9| 1| 0| 9| 9| 1| 0| 0| 9| 9| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    62.5 PPM                               | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
      Hyperplasia                          |                2                          2                 4     3      |             
      Hypertrophy                          |    1  2  2  1        1  2     1     1           2  1  1  2  1     1      |             
                                            __________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                        1                                 |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |    1                                                                     |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  M  +  M  +  M  +  +  +  M  +  M  M  +  M  +  M  +  M  +  +|             
      Cyst                                 |                   2                                                      |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +|             
      Pars Distalis, Hyperplasia           |                                           2                              |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Follicular Cell, Hyperplasia         |       1           1        1                             1  1            |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Granuloma Sperm                      |                                              2                           |             
      Inflammation                         |                      2           1                                       |             
                                            __________________________________________________________________________|             
   Preputial Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +|             
      Ectasia                              |                                                                          |             
      Inflammation                         |                1  2        2                       4        2        2   |             
                                            __________________________________________________________________________|             
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +|             
      Inflammation                         |                                                                      2   |             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                1                             3                           |             
      Interstitial Cell, Hyperplasia       |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                                                      2   |             
                                            __________________________________________________________________________|             
   Lymph Node                              |                                              +                           |             
                                            __________________________________________________________________________|             
   Lymph Node, Bronchial                   | +  +  +  +  M  M  M  +  +  +  +  M  M  M  M  +  +  +  +  +  M  +  +  M  M|             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  M  +  M  M  M  M  M  +  M  +  M  +  M  M  M  +  M  +  +  +  +  M  +  +|             
      Hyperplasia                          |                                                          2               |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |             1                                                        2   |             
      Hematopoietic Cell Proliferation     |             1                                                            |             
      Hyperplasia                          |                                                 2  2        2  2     2  2|             
                                            __________________________________________________________________________|             
   Lymph Node, Mediastinal                 | +  +  +  M  +  +  +  +  M  +  M  +  +  M  +  +  +  +  +  +  +  M  +  M  M|             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hematopoietic Cell Proliferation     |       2           2           3        2                             4  3|             
 _____________________________________________________________________________________________________________________|             

                                                             Page  42                                                               
NTP Experiment-Test: 05197-12                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          2-BUTOXYETHANOL                                      Date: 01/21/98  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 10:57:48  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 6| 7| 7| 6| 5| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 3| 2| 3| 2| 3| 2| 5| 3| 2| 3| 4| 3| 3| 8| 4| 1| 3| 2| 2| 3| 3| 3| 2| 2| 2|             
                                           | 0| 9| 0| 9| 0| 9| 6| 0| 9| 1| 9| 0| 0| 1| 9| 1| 0| 9| 9| 1| 0| 0| 9| 9| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    62.5 PPM                               | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Hyperplasia, Lymphoid                |             2                    2                       2  2  2  2     2|             
      Pigmentation, Hemosiderin            |                                                                          |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  M  M  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +|             
      Atrophy                              |                                              4                           |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M|             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation                         |                                                                          |             
      Prepuce, Inflammation, Chronic Active|                   4                                                     3|             
      Prepuce, Ulcer                       |                   2                                                     2|             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrous Osteodystrophy               |    1  1                          1                                      1|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Meninges, Infiltration Cellular,     |                                                                          |             
           Mononuclear Cell                |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Larynx                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Squamous Epithelium, Hyperplasia     |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |    1                 1              1                                    |             
      Infiltration Cellular, Histiocyte    |                                                                   3      |             
      Alveolar Epithelium, Hyperplasia     |                                                                          |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Suppurative            |                                                 1                        |             
      Polyp, Inflammatory                  |                                                                          |             
      Olfactory Epithelium, Atrophy        |                                                                          |             
      Olfactory Epithelium, Degeneration,  |                                                                          |             
           Hyaline                         |                                                                          |             
      Respiratory Epithelium, Degeneration,|                                                                          |             
           Hyaline                         |       1           1                                1  1                  |             
      Respiratory Epithelium, Metaplasia,  |                                                                          |             
           Squamous                        |                                                                          |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |          +  +                                                            |             
                                            __________________________________________________________________________|             
   Zymbal's Gland                          |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
 _____________________________________________________________________________________________________________________|             

                                                             Page  43                                                               
NTP Experiment-Test: 05197-12                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          2-BUTOXYETHANOL                                      Date: 01/21/98  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 10:57:48  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 6| 7| 7| 6| 5| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 3| 2| 3| 2| 3| 2| 5| 3| 2| 3| 4| 3| 3| 8| 4| 1| 3| 2| 2| 3| 3| 3| 2| 2| 2|             
                                           | 0| 9| 0| 9| 0| 9| 6| 0| 9| 1| 9| 0| 0| 1| 9| 1| 0| 9| 9| 1| 0| 0| 9| 9| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    62.5 PPM                               | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Glomerulosclerosis                   |                1  1                          1                           |             
      Inflammation, Chronic Active         |                                                                          |             
      Metaplasia, Osseous                  |                      1        1                                          |             
      Nephropathy                          | 1  2  3  1  1  1  1  1  1  1  4  1  1  3        1  1  2  1  1  1  1  2  1|             
      Cortex, Cyst                         |                                                                          |             
      Pelvis, Inflammation, Chronic Active |                                                                      2   |             
      Renal Tubule, Hyperplasia            |                                     1              1                     |             
      Renal Tubule, Mineralization         |          1  1                                                            |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation                         |                                                                      3   |             
      Transitional Epithelium, Hyperplasia |                                                                      3   |             
      Transitional Epithelium, Ulcer       |                                                                          |             
 _____________________________________________________________________________________________________________________|             

                                                             Page  44                                                               
NTP Experiment-Test: 05197-12                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          2-BUTOXYETHANOL                                      Date: 01/21/98  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 10:57:48  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 6| 7|            |
                             DAY ON TEST   | 3| 2| 0| 0| 3| 3| 2| 0| 2| 3| 2| 2| 2| 2| 3| 3| 3| 2| 3| 3| 2| 3| 7| 8| 2|            |
                                           | 0| 9| 1| 7| 0| 0| 9| 5| 1| 0| 9| 9| 9| 9| 0| 0| 0| 9| 0| 0| 9| 1| 0| 1| 9|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|      A     |
    62.5 PPM                               | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Gallbladder                             | +  +  A  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  45        |
      Degeneration, Hyaline                |             3                                                            |      1  3.0|
      Inflammation                         |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  A  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  A  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  A  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  47        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  A  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  47        |
      Peyer's Patch, Hyperplasia           |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Degeneration, Fatty                  |                                        1                                 |      2  1.0|
      Eosinophilic Focus                   |                   X        X     X           X           X        X      |     10     |
      Hematopoietic Cell Proliferation     |                                                                          |      1  1.0|
      Infarct                              |                   4                                                      |      1  4.0|
      Inflammation                         |                         2              1                                 |      3  1.3|
      Necrosis                             |                         2                                                |      2  2.5|
      Oval Cell, Hyperplasia               |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Mesentery                               |                                                 +                        |   3        |
      Angiectasis                          |                                                                          |      1  3.0|
      Fat, Necrosis                        |                                                 2                        |      2  2.0|
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Atrophy                              |                                                                      1   |      4  1.0|
      Degeneration, Hyaline                |                                                                          |      1  2.0|
      Inflammation                         |                      2                                                   |      1  2.0|
      Duct, Cyst                           |                      2                                                   |      1  2.0|
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inflammation                         |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Ulcer                                |                         1                                                |      2  1.5|
      Epithelium, Hyperplasia              |       1     4           2     2  1  3                                    |      7  2.3|
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Mineralization                       |                                                                          |      1  1.0|
      Ulcer                                |          1                                                               |      1  1.0|
                                            __________________________________________________________________________|____________|
   Tooth                                   | +        +                 +     +                                       |   4        |
      Malformation                         | X        X                 X     X                                       |      4     |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 

  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        

                                                             Page  45                                                               
NTP Experiment-Test: 05197-12                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          2-BUTOXYETHANOL                                      Date: 01/21/98  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 10:57:48  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 6| 7|            |
                             DAY ON TEST   | 3| 2| 0| 0| 3| 3| 2| 0| 2| 3| 2| 2| 2| 2| 3| 3| 3| 2| 3| 3| 2| 3| 7| 8| 2|            |
                                           | 0| 9| 1| 7| 0| 0| 9| 5| 1| 0| 9| 9| 9| 9| 0| 0| 0| 9| 0| 0| 9| 1| 0| 1| 9|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|      A     |
    62.5 PPM                               | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 __________________________________________________________________________________________________________________________________ 
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cardiomyopathy                       | 1  1     1  1  1  1  2  1  1  1  1  1  1  1  1  1  1  1  2  1  1  1  1  1|     48  1.1|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia                          |          2  2                       2        4        3                  |      9  2.7|
      Hypertrophy                          | 1  1              1              1  1  2  2     1  1     1  3  3  1     1|     28  1.4|
                                            __________________________________________________________________________|____________|
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia                          |                                                             2            |      2  1.5|
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia                          |          1                       1                                       |      3  1.0|
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  M  M  +  M  +  +  M  +  M  +  +  M  +  M  M  +  M  +  +  +  M  M  M  +|  29        |
      Cyst                                 |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Pars Distalis, Hyperplasia           |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +|  48        |
      Follicular Cell, Hyperplasia         |             2        1                    1                              |      8  1.1|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Granuloma Sperm                      |                                                                          |      1  2.0|
      Inflammation                         |             1                                      1                     |      4  1.3|
                                            __________________________________________________________________________|____________|
   Preputial Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Ectasia                              |                                           3                              |      1  3.0|
      Inflammation                         |                                                 3                        |      7  2.3|
                                            __________________________________________________________________________|____________|
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Inflammation                         |          2                                                               |      2  2.0|
                                            __________________________________________________________________________|____________|
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Atrophy                              |                                                    1              1      |      4  1.5|
      Interstitial Cell, Hyperplasia       |                                  1                                       |      1  1.0|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia                          |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Lymph Node                              |                                                                          |   1        |
 __________________________________________________________________________________________________________________________________ 

  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        

                                                             Page  46                                                               
NTP Experiment-Test: 05197-12                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          2-BUTOXYETHANOL                                      Date: 01/21/98  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 10:57:48  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 6| 7|            |
                             DAY ON TEST   | 3| 2| 0| 0| 3| 3| 2| 0| 2| 3| 2| 2| 2| 2| 3| 3| 3| 2| 3| 3| 2| 3| 7| 8| 2|            |
                                           | 0| 9| 1| 7| 0| 0| 9| 5| 1| 0| 9| 9| 9| 9| 0| 0| 0| 9| 0| 0| 9| 1| 0| 1| 9|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|      A     |
    62.5 PPM                               | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lymph Node, Bronchial                   | +  +  +  +  +  M  +  +  +  M  +  M  +  +  M  +  +  +  +  +  +  M  +  +  +|  35        |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | M  +  +  M  +  +  +  M  +  M  M  +  +  +  +  M  M  +  M  M  M  M  +  +  +|  26        |
      Hyperplasia                          |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Angiectasis                          |                                                                          |      2  1.5|
      Hematopoietic Cell Proliferation     |          2                 2                                             |      3  1.7|
      Hyperplasia                          | 2                                                                        |      7  2.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mediastinal                 | +  M  +  M  M  M  +  +  +  +  +  +  +  +  +  +  M  M  M  M  +  M  +  +  M|  33        |
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hematopoietic Cell Proliferation     |             2        2  2  3  2                                          |     11  2.5|
      Hyperplasia, Lymphoid                |                                           2                              |      8  2.0|
      Pigmentation, Hemosiderin            |    1     1        1  1                          1  1                     |      6  1.0|
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  M|  43        |
      Atrophy                              |                                                                          |      1  4.0|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M|            |
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inflammation                         |                                                                   4      |      1  4.0|
      Prepuce, Inflammation, Chronic Active|          4                                                               |      3  3.7|
      Prepuce, Ulcer                       |          4                                                               |      3  2.7|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Fibrous Osteodystrophy               |                                                                          |      4  1.0|
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Meninges, Infiltration Cellular,     |                                                                          |            |
           Mononuclear Cell                |                1                                                         |      1  1.0|
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Larynx                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Squamous Epithelium, Hyperplasia     |    1  1                                                           2      |      3  1.3|
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hemorrhage                           |             1                                            1               |      5  1.0|
      Infiltration Cellular, Histiocyte    |                                                                          |      1  3.0|
      Alveolar Epithelium, Hyperplasia     |                   2                                                      |      1  2.0|
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 __________________________________________________________________________________________________________________________________ 

  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        

                                                             Page  47                                                               
NTP Experiment-Test: 05197-12                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          2-BUTOXYETHANOL                                      Date: 01/21/98  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 10:57:48  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 6| 7|            |
                             DAY ON TEST   | 3| 2| 0| 0| 3| 3| 2| 0| 2| 3| 2| 2| 2| 2| 3| 3| 3| 2| 3| 3| 2| 3| 7| 8| 2|            |
                                           | 0| 9| 1| 7| 0| 0| 9| 5| 1| 0| 9| 9| 9| 9| 0| 0| 0| 9| 0| 0| 9| 1| 0| 1| 9|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|      A     |
    62.5 PPM                               | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 __________________________________________________________________________________________________________________________________ 
 RESPIRATORY SYSTEM - cont                 |                                                                          |            |
                                           |                                                                          |            |
      Inflammation, Suppurative            | 2        1                       2                       1           1   |      6  1.3|
      Polyp, Inflammatory                  |                                  2                                       |      1  2.0|
      Olfactory Epithelium, Atrophy        |          2                 2     3                                   1   |      4  2.0|
      Olfactory Epithelium, Degeneration,  |                                                                          |            |
           Hyaline                         | 1                          1                                             |      2  1.0|
      Respiratory Epithelium, Degeneration,|                                                                          |            |
           Hyaline                         |    1  1  1                 2        1                             1      |     10  1.1|
      Respiratory Epithelium, Metaplasia,  |                                                                          |            |
           Squamous                        |          1                                                               |      1  1.0|
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Harderian Gland                         |                                           +                              |   3        |
                                            __________________________________________________________________________|____________|
   Zymbal's Gland                          |                   +                                                      |   1        |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Glomerulosclerosis                   |                         2                                                |      4  1.3|
      Inflammation, Chronic Active         |          2                                                               |      1  2.0|
      Metaplasia, Osseous                  |                                                                          |      2  1.0|
      Nephropathy                          | 1  1  1     3  1     1     1  1  1  1  1  1  1  1  1  1  1  1  1  2  1  1|     45  1.3|
      Cortex, Cyst                         |                                                       1                  |      1  1.0|
      Pelvis, Inflammation, Chronic Active |                                                                          |      1  2.0|
      Renal Tubule, Hyperplasia            |                                                                          |      2  1.0|
      Renal Tubule, Mineralization         |                                                                          |      2  1.0|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inflammation                         |          4                                                               |      2  3.5|
      Transitional Epithelium, Hyperplasia |                                                                      3   |      2  3.0|
      Transitional Epithelium, Ulcer       |          3                                                               |      1  3.0|
 __________________________________________________________________________________________________________________________________ 

  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        

                                                             Page  48                                                               
NTP Experiment-Test: 05197-12                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          2-BUTOXYETHANOL                                      Date: 01/21/98  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 10:57:48  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 7| 7| 5| 7| 7| 7| 7| 5| 5| 7| 7| 7| 5| 5| 7| 5| 5| 7| 6| 7| 7| 7| 7|             
                             DAY ON TEST   | 8| 3| 3| 3| 8| 2| 2| 2| 3| 8| 6| 3| 3| 3| 9| 8| 2| 8| 0| 2| 1| 2| 3| 3| 2|             
                                           | 1| 0| 1| 0| 3| 9| 9| 9| 0| 3| 7| 0| 0| 0| 7| 5| 9| 2| 2| 9| 8| 9| 1| 1| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    125 PPM                                | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Gallbladder                             | +  +  M  +  +  +  +  +  M  +  A  +  +  +  A  M  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  A  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  A  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  A  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  A  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                  1                                       |             
      Basophilic Focus                     |                                                             X            |             
      Clear Cell Focus                     |    X  X                                                  X               |             
      Degeneration, Fatty                  |                                                       1  1               |             
      Eosinophilic Focus                   | X     X     X                          X        X        X  X     X  X   |             
      Hematopoietic Cell Proliferation     |                                                             1            |             
      Hepatodiaphragmatic Nodule           |                                                                          |             
      Inflammation                         |                                                 1                    1   |             
      Necrosis                             |                                                             1            |             
      Bile Duct, Cyst                      |                                                                          |             
      Kupffer Cell, Pigmentation,          |                                                                          |             
          Hemosiderin                      |                1              1                                          |             
      Oval Cell, Hyperplasia               |                                                 1        1               |             
                                            __________________________________________________________________________|             
   Mesentery                               |    +                                      +                    +         |             
      Fat, Necrosis                        |    2                                                           3         |             
                                            __________________________________________________________________________|             
   Oral Mucosa                             |                                                                          |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                                                          1               |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation                         |             1                                                            |             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                  2                                       |             
      Ulcer                                |                                  1                                       |             
      Epithelium, Hyperplasia              |                            1  3           1           1  1           1   |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +|             
      Degeneration, Hyaline                |    1                                                                     |             
      Mineralization                       |                1                                                         |             
      Ulcer                                |                                                       2                  |             
      Epithelium, Hyperplasia              |             1  1                                            1            |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cardiomyopathy                       | 2  1  1  1  1  1  1  1  1  1  2  1  1  1  1     1  1  1  1  1  1  1  1  1|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             

                                                             Page  49                                                               
NTP Experiment-Test: 05197-12                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          2-BUTOXYETHANOL                                      Date: 01/21/98  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 10:57:48  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 7| 7| 5| 7| 7| 7| 7| 5| 5| 7| 7| 7| 5| 5| 7| 5| 5| 7| 6| 7| 7| 7| 7|             
                             DAY ON TEST   | 8| 3| 3| 3| 8| 2| 2| 2| 3| 8| 6| 3| 3| 3| 9| 8| 2| 8| 0| 2| 1| 2| 3| 3| 2|             
                                           | 1| 0| 1| 0| 3| 9| 9| 9| 0| 3| 7| 0| 0| 0| 7| 5| 9| 2| 2| 9| 8| 9| 1| 1| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    125 PPM                                | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hematopoietic Cell Proliferation     |                                                                          |             
      Hyperplasia                          |          2        1  2                             2  1  1     1         |             
      Hypertrophy                          |    1  1        2  1  2  3        2  2  1              1  1  1  1  1  2   |             
                                            __________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                         1                                            1   |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | M  M  +  M  +  M  +  +  M  M  M  M  +  M  M  +  +  +  +  +  +  M  M  M  +|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |                                                                          |             
      Pars Distalis, Hyperplasia           |                                                                   2      |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Follicular Cell, Hyperplasia         |                         1                                   1           1|             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Granulomatous          |                                                                         3|             
      Inflammation                         |                                                                          |             
                                            __________________________________________________________________________|             
   Penis                                   |                                                                          |             
      Inflammation                         |                                                                          |             
                                            __________________________________________________________________________|             
   Preputial Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation                         | 1                                                        2  4            |             
                                            __________________________________________________________________________|             
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation                         |                                                             2            |             
      Epithelium, Hyperplasia              |    2                                                                     |             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +|             
      Inflammation                         |                                        3                                 |             
                                            __________________________________________________________________________|             
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |          2  1                                2                    2      |             
      Mineralization                       |          2                                   1                    1      |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrosis                             |                                                                          |             
      Hyperplasia                          | 2        2                 2                       2        3            |             
                                            __________________________________________________________________________|             
   Lymph Node, Bronchial                   | M  +  +  +  M  +  +  +  +  M  M  M  +  +  +  M  +  +  +  +  M  +  +  +  +|             
      Hyperplasia                          |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  M  M  +  +  +  M  +  M  +  +  M  +  +  M  +  +  +  M  +  M  M  +  +|             
      Hyperplasia                          |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hematopoietic Cell Proliferation     |                                                                          |             
 _____________________________________________________________________________________________________________________|             

                                                             Page  50                                                               
NTP Experiment-Test: 05197-12                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          2-BUTOXYETHANOL                                      Date: 01/21/98  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 10:57:48  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 7| 7| 5| 7| 7| 7| 7| 5| 5| 7| 7| 7| 5| 5| 7| 5| 5| 7| 6| 7| 7| 7| 7|             
                             DAY ON TEST   | 8| 3| 3| 3| 8| 2| 2| 2| 3| 8| 6| 3| 3| 3| 9| 8| 2| 8| 0| 2| 1| 2| 3| 3| 2|             
                                           | 1| 0| 1| 0| 3| 9| 9| 9| 0| 3| 7| 0| 0| 0| 7| 5| 9| 2| 2| 9| 8| 9| 1| 1| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    125 PPM                                | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Hyperplasia                          | 2                    4                                                   |             
                                            __________________________________________________________________________|             
   Lymph Node, Mediastinal                 | M  +  +  M  M  +  +  +  +  +  +  +  M  M  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hematopoietic Cell Proliferation     | 2        2  3  2  2        1     2                 2  2  2  4  2  2      |             
      Hyperplasia, Lymphoid                |    2           2                                                         |             
      Pigmentation, Hemosiderin            |    2  2  2     2  2  2  2  2  2  2  2  1  2  2  2  2  2  2     2  2  2  1|             
                                            __________________________________________________________________________|             
   Thymus                                  | M  +  +  +  M  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  M  +  M  +|             
      Atrophy                              |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M|             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Granuloma                            |                               4                                          |             
      Pigmentation, Melanin                |                               1                                          |             
      Prepuce, Hyperplasia                 |                                                                          |             
      Prepuce, Inflammation, Chronic Active| 4        4                 4              2        4        4            |             
      Prepuce, Ulcer                       | 3        2                 3                       4        4            |             
      Subcutaneous Tissue, Inflammation,   |                                                                          |             
           Granulomatous                   |                               3                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Vacuolization Cytoplasmic            |                1                                                         |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Larynx                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hematopoietic Cell Proliferation     |                                                                          |             
      Hemorrhage                           |                      1              1                                    |             
      Infiltration Cellular, Histiocyte    |                2     2                          3                        |             
      Inflammation, Chronic                |                                                                          |             
      Alveolar Epithelium, Hyperplasia     |                                                                          |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Suppurative            |                                                 1                        |             
      Polyp, Inflammatory                  |                                                                          |             
      Olfactory Epithelium, Atrophy        |          1                                                               |             
      Olfactory Epithelium, Degeneration,  |                                                                          |             
           Hyaline                         |             1                                                            |             
      Respiratory Epithelium, Degeneration,|                                                                          |             
           Hyaline                         |                   1                                                      |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             

                                                             Page  51                                                               
NTP Experiment-Test: 05197-12                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          2-BUTOXYETHANOL                                      Date: 01/21/98  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 10:57:48  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 7| 7| 5| 7| 7| 7| 7| 5| 5| 7| 7| 7| 5| 5| 7| 5| 5| 7| 6| 7| 7| 7| 7|             
                             DAY ON TEST   | 8| 3| 3| 3| 8| 2| 2| 2| 3| 8| 6| 3| 3| 3| 9| 8| 2| 8| 0| 2| 1| 2| 3| 3| 2|             
                                           | 1| 0| 1| 0| 3| 9| 9| 9| 0| 3| 7| 0| 0| 0| 7| 5| 9| 2| 2| 9| 8| 9| 1| 1| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    125 PPM                                | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                                                                          |             
      Cornea, Inflammation, Chronic        |                                                                          |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |          +                                                               |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Glomerulosclerosis                   |             2  1           1  3  1        1  1              1            |             
      Hydronephrosis                       |             2                                      2                     |             
      Inflammation, Chronic Active         |                                                             2            |             
      Nephropathy                          | 1  1  1  1  1  1  1  1  1  1  1  1  1  1     1  1        1     1  2  1  1|             
      Pelvis, Inflammation, Chronic Active | 2                                                                        |             
      Renal Tubule, Hyperplasia            |                                                                          |             
      Renal Tubule, Mineralization         | 2        1                                                               |             
      Renal Tubule, Necrosis               |                                                                          |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation                         | 4                                                  1        4            |             
      Transitional Epithelium, Hyperplasia |                                                                          |             
      Transitional Epithelium, Ulcer       | 3                                                           2            |             
 _____________________________________________________________________________________________________________________|             

                                                             Page  52                                                               
NTP Experiment-Test: 05197-12                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          2-BUTOXYETHANOL                                      Date: 01/21/98  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 10:57:48  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 5| 6| 6| 6| 7| 4| 7| 5| 7| 7| 4| 4| 6| 7| 7| 6| 5| 6| 7| 7| 7| 7| 7|            |
                             DAY ON TEST   | 3| 3| 3| 7| 9| 0| 2| 5| 3| 6| 3| 2| 3| 2| 4| 0| 2| 5| 1| 6| 3| 2| 3| 2| 0|            |
                                           | 0| 0| 7| 0| 8| 0| 9| 7| 1| 3| 0| 9| 0| 1| 7| 5| 9| 5| 1| 3| 0| 9| 0| 9| 4|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|      A     |
    125 PPM                                | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Gallbladder                             | +  +  +  +  +  A  +  M  +  +  +  +  +  A  A  +  +  +  A  +  +  +  +  +  +|  40        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  A  +  +  +  +  +  A  +  +  +  +  A  +  +  +  +  +  +|  46        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  A  +  +  +  +  +  A  +  +  +  +  A  +  +  +  +  +  +|  46        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  A  +  A  +  +  +  +  +  A  A  +  +  +  +  +  +  +  +  +  +|  44        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  A  +  +  +  +  +  A  A  +  +  +  A  +  +  +  +  +  +|  44        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  A  +  +  +  +  +  A  A  +  +  +  A  +  +  +  +  +  A|  43        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  A  +  +  +  +  +  A  A  +  +  +  A  +  +  +  +  +  A|  43        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Angiectasis                          |                                                                          |      1  1.0|
      Basophilic Focus                     |                                                                          |      1     |
      Clear Cell Focus                     | X                                               X                        |      5     |
      Degeneration, Fatty                  | 2                                                  2                     |      4  1.5|
      Eosinophilic Focus                   | X  X  X           X           X     X     X        X                 X   |     18     |
      Hematopoietic Cell Proliferation     |                            1                                             |      2  1.0|
      Hepatodiaphragmatic Nodule           | X                                                                        |      1     |
      Inflammation                         |             2                    2                       3  2            |      6  1.8|
      Necrosis                             |             2                    1                    4  4     1        2|      7  2.1|
      Bile Duct, Cyst                      |                                                                3         |      1  3.0|
      Kupffer Cell, Pigmentation,          |                                                                          |            |
          Hemosiderin                      | 1  1     1                                         1     1     1         |      8  1.0|
      Oval Cell, Hyperplasia               |                                                                          |      2  1.0|
                                            __________________________________________________________________________|____________|
   Mesentery                               |                                                                          |   3        |
      Fat, Necrosis                        |                                                                          |      2  2.5|
                                            __________________________________________________________________________|____________|
   Oral Mucosa                             |    +                                                                     |   1        |
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  A  +  +  +  +  +  A  +  +  +  +  A  +  +  +  +  +  +|  47        |
      Atrophy                              |                                  1                                       |      2  1.0|
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  A  M  +  +  +  +  +  +  +  +  +  +|  48        |
      Inflammation                         |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Hyperplasia                          |                                                                          |      1  2.0|
      Ulcer                                |    2     2           1        1              1     2           2  2      |      9  1.6|
      Epithelium, Hyperplasia              |    4     4           1                       1  1  2  1  1        4     1|     16  1.8|
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  A  +  +  +  +  +  A  +  +  +  +  A  +  +  +  +  +  +|  46        |
      Degeneration, Hyaline                |                                                                          |      1  1.0|
      Mineralization                       |                                                                          |      1  1.0|
      Ulcer                                |                            1                                             |      2  1.5|
      Epithelium, Hyperplasia              |       1                                                                  |      4  1.0|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 

  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        

                                                             Page  53                                                               
NTP Experiment-Test: 05197-12                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          2-BUTOXYETHANOL                                      Date: 01/21/98  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 10:57:48  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 5| 6| 6| 6| 7| 4| 7| 5| 7| 7| 4| 4| 6| 7| 7| 6| 5| 6| 7| 7| 7| 7| 7|            |
                             DAY ON TEST   | 3| 3| 3| 7| 9| 0| 2| 5| 3| 6| 3| 2| 3| 2| 4| 0| 2| 5| 1| 6| 3| 2| 3| 2| 0|            |
                                           | 0| 0| 7| 0| 8| 0| 9| 7| 1| 3| 0| 9| 0| 1| 7| 5| 9| 5| 1| 3| 0| 9| 0| 9| 4|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|      A     |
    125 PPM                                | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 __________________________________________________________________________________________________________________________________ 
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |            |
                                           |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cardiomyopathy                       | 2  1  1  1  1  1  1     2  1  1  1  1     1  1  1  1  1  2  1  1  1  1  1|     47  1.1|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Hematopoietic Cell Proliferation     |                2                                                         |      1  2.0|
      Hyperplasia                          |                                  2                                   2   |      9  1.6|
      Hypertrophy                          | 2           1     2     2     1  1  1     1  1              1     2  1   |     27  1.4|
                                            __________________________________________________________________________|____________|
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  A  +  +  +  +  +  A  +  +  +  +  A  +  +  +  +  +  +|  47        |
      Hyperplasia                          |                                                                          |      2  1.0|
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | M  +  +  +  M  M  +  M  +  M  +  +  +  M  M  M  +  +  M  +  M  +  +  M  +|  26        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  M  +  +  A  +  +  +  +  +  A  +  M  +  +  +  +  +  +  +  +  +|  46        |
      Hemorrhage                           |                                           4                              |      1  4.0|
      Pars Distalis, Hyperplasia           |                            4                                             |      2  3.0|
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Follicular Cell, Hyperplasia         | 1                                                        1  1            |      6  1.0|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Inflammation, Granulomatous          |                                                                          |      1  3.0|
      Inflammation                         | 1                                                                        |      1  1.0|
                                            __________________________________________________________________________|____________|
   Penis                                   |                         +                                                |   1        |
      Inflammation                         |                         2                                                |      1  2.0|
                                            __________________________________________________________________________|____________|
   Preputial Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Inflammation                         |                                                             1     3     3|      6  2.3|
                                            __________________________________________________________________________|____________|
   Prostate                                | +  +  +  +  +  +  +  A  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Inflammation                         |       3                    2                                             |      3  2.3|
      Epithelium, Hyperplasia              |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Seminal Vesicle                         | +  +  +  +  +  +  +  A  +  +  +  +  +  A  +  +  +  +  A  +  +  +  +  +  +|  46        |
      Inflammation                         |                                              1                           |      2  2.0|
                                            __________________________________________________________________________|____________|
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Atrophy                              |                               1                          2               |      6  1.7|
      Mineralization                       |                                                                          |      3  1.3|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 

  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        

                                                             Page  54                                                               
NTP Experiment-Test: 05197-12                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          2-BUTOXYETHANOL                                      Date: 01/21/98  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 10:57:48  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 5| 6| 6| 6| 7| 4| 7| 5| 7| 7| 4| 4| 6| 7| 7| 6| 5| 6| 7| 7| 7| 7| 7|            |
                             DAY ON TEST   | 3| 3| 3| 7| 9| 0| 2| 5| 3| 6| 3| 2| 3| 2| 4| 0| 2| 5| 1| 6| 3| 2| 3| 2| 0|            |
                                           | 0| 0| 7| 0| 8| 0| 9| 7| 1| 3| 0| 9| 0| 1| 7| 5| 9| 5| 1| 3| 0| 9| 0| 9| 4|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|      A     |
    125 PPM                                | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Fibrosis                             |                   1                                                      |      1  1.0|
      Hyperplasia                          |       2                 3  2                                            2|      9  2.2|
                                            __________________________________________________________________________|____________|
   Lymph Node, Bronchial                   | +  +  +  +  M  +  +  M  +  +  M  +  M  A  M  M  +  +  +  M  M  M  +  +  +|  33        |
      Hyperplasia                          |    2                                                                     |      1  2.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  M  +  M  +  M  +  A  M  +  +  +  +  +  M  M  +  M  M|  32        |
      Hyperplasia                          |                                     2                                    |      1  2.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  M  +  +  +  +  +  A  +  +  +  +  +  M  +  +  +  +  +|  47        |
      Hematopoietic Cell Proliferation     |                            2                                             |      1  2.0|
      Hyperplasia                          |                                                                      2  2|      4  2.5|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mediastinal                 | +  +  +  +  +  M  +  +  +  +  +  +  +  A  +  +  +  +  M  +  M  +  +  M  +|  40        |
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  A  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Hematopoietic Cell Proliferation     |    2  3  3  2  2  1     2  3     1                       3     4  2     4|     26  2.3|
      Hyperplasia, Lymphoid                | 2                                                                        |      3  2.0|
      Pigmentation, Hemosiderin            | 1  2  2  1  1  1  1     1  2  2  2  2     1  2  1  1  2  2  1  1  1  1  1|     45  1.6|
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +  +  +  +  +  M  M  M  +  +  +  +  A  +  M  M  +  M  M  +  +  +  M  +|  36        |
      Atrophy                              |                                                                         3|      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M|            |
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Granuloma                            |                                                                          |      1  4.0|
      Pigmentation, Melanin                |                                                                          |      1  1.0|
      Prepuce, Hyperplasia                 |                                                                         1|      1  1.0|
      Prepuce, Inflammation, Chronic Active|    4  4        4        4  4                                4     2      |     13  3.7|
      Prepuce, Ulcer                       |    1  3        3           3                                4     1      |     11  2.8|
      Subcutaneous Tissue, Inflammation,   |                                                                          |            |
           Granulomatous                   |                                                                          |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Vacuolization Cytoplasmic            |                                                                          |      1  1.0|
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Larynx                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  A  +  +  +  +  +  +|  48        |
 __________________________________________________________________________________________________________________________________ 

  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        

                                                             Page  55                                                               
NTP Experiment-Test: 05197-12                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          2-BUTOXYETHANOL                                      Date: 01/21/98  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 10:57:48  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 5| 6| 6| 6| 7| 4| 7| 5| 7| 7| 4| 4| 6| 7| 7| 6| 5| 6| 7| 7| 7| 7| 7|            |
                             DAY ON TEST   | 3| 3| 3| 7| 9| 0| 2| 5| 3| 6| 3| 2| 3| 2| 4| 0| 2| 5| 1| 6| 3| 2| 3| 2| 0|            |
                                           | 0| 0| 7| 0| 8| 0| 9| 7| 1| 3| 0| 9| 0| 1| 7| 5| 9| 5| 1| 3| 0| 9| 0| 9| 4|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|      A     |
    125 PPM                                | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 __________________________________________________________________________________________________________________________________ 
 RESPIRATORY SYSTEM - cont                 |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Hematopoietic Cell Proliferation     |                2                                                         |      1  2.0|
      Hemorrhage                           |                         1                    2                       1   |      5  1.2|
      Infiltration Cellular, Histiocyte    |    4                                                                     |      4  2.8|
      Inflammation, Chronic                |    2                                                                     |      1  2.0|
      Alveolar Epithelium, Hyperplasia     |    2                                                     1               |      2  1.5|
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  A  +  +  +  +  +  +|  48        |
      Inflammation, Suppurative            |                   2                                                      |      2  1.5|
      Polyp, Inflammatory                  |                   4                                                      |      1  4.0|
      Olfactory Epithelium, Atrophy        |                   2           1                                          |      3  1.3|
      Olfactory Epithelium, Degeneration,  |                                                                          |            |
           Hyaline                         |                   2                                         1            |      3  1.3|
      Respiratory Epithelium, Degeneration,|                                                                          |            |
           Hyaline                         |             2     2                                1                 1   |      5  1.4|
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  A  +  +  +  +  +  A  +  +  +  +  A  +  +  +  +  +  +|  47        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Eye                                     |                               +                                          |   1        |
      Cornea, Inflammation, Chronic        |                               3                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Harderian Gland                         |                               +                                          |   2        |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  A  +  A  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +|  47        |
      Glomerulosclerosis                   |                                     1                    1        1      |     11  1.3|
      Hydronephrosis                       |       1                 2  2                             2               |      6  1.8|
      Inflammation, Chronic Active         |                            3                                             |      2  2.5|
      Nephropathy                          | 2  1  1  2  1     1     1     1  1  1     1     1  1     2  1  2  2  1  1|     40  1.2|
      Pelvis, Inflammation, Chronic Active |                                                                          |      1  2.0|
      Renal Tubule, Hyperplasia            |                         1                                                |      1  1.0|
      Renal Tubule, Mineralization         |                                              1                           |      3  1.3|
      Renal Tubule, Necrosis               |                                              2                           |      1  2.0|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  A  +  A  +  +  +  +  +  A  +  +  +  +  A  +  +  +  +  +  +|  46        |
      Inflammation                         |       4                    4                                             |      5  3.4|
      Transitional Epithelium, Hyperplasia |       2                                                                  |      1  2.0|
      Transitional Epithelium, Ulcer       |       3                    3                                             |      4  2.8|
 __________________________________________________________________________________________________________________________________ 

  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        

                                                             Page  56                                                               
NTP Experiment-Test: 05197-12                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          2-BUTOXYETHANOL                                      Date: 01/21/98  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 10:57:48  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 4| 7| 6| 6| 7| 7| 6| 6| 7| 7| 7| 6| 6| 3| 7| 0| 7| 7| 7| 7| 6| 7| 7| 7|             
                             DAY ON TEST   | 3| 0| 3| 9| 3| 3| 2| 8| 6| 2| 3| 3| 8| 0| 7| 2| 7| 2| 2| 3| 2| 7| 2| 3| 3|             
                                           | 0| 2| 0| 4| 8| 0| 9| 4| 5| 9| 0| 0| 4| 4| 4| 9| 3| 9| 9| 0| 9| 0| 9| 0| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|             
    250 PPM                                | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Gallbladder                             | +  A  +  +  A  +  +  M  A  +  +  +  +  A  +  +  +  M  +  +  +  +  M  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  A  +  +  +  +  +  +  A  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  A  +  +  +  +  +  +  A  +  +  +  +  A  +  +  +  +  +  +  +  +  M  +  +|             
      Inflammation                         |                      2                                                   |             
      Epithelium, Hyperplasia              |                      1                                                   |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  A  +  +  A  +  +  +  A  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +|             
      Peyer's Patch, Hyperplasia           |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  A  +  +  A  +  +  +  A  +  +  +  +  A  A  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Basophilic Focus                     |                                                                          |             
      Clear Cell Focus                     |                            X                                      X      |             
      Eosinophilic Focus                   |       X           X                                      X           X  X|             
      Hematopoietic Cell Proliferation     |                                                             2  2         |             
      Inflammation                         |          2     1                 2                                       |             
      Karyomegaly                          |                                                                      1   |             
      Necrosis                             |    1                                   2  1                              |             
      Bile Duct, Cyst                      |                                                                          |             
      Kupffer Cell, Pigmentation,          |                                                                          |             
          Hemosiderin                      |             1     1  1  3  1     2  1  1  1  1     1        1  1     1   |             
      Oval Cell, Hyperplasia               |                1                                                     1   |             
                                            __________________________________________________________________________|             
   Mesentery                               |                                                                          |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                                  1                 1              1      |             
      Cytoplasmic Alteration               |                                                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation                         |                                                          1               |             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Mineralization                       |                1                                                         |             
      Ulcer                                |                      2           1                                       |             
      Epithelium, Hyperplasia              |       2        2  3           3  3        1           2  1  4     2  1   |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Mineralization                       |                1                                                         |             
      Epithelium, Hyperplasia              |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cardiomyopathy                       | 1  1  1  1  1  1  1  1  1  1  1  1  1  2  1  2     1  1  1  1  1  1  1  1|             
      Atrium, Thrombosis                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             

                                                             Page  57                                                               
NTP Experiment-Test: 05197-12                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          2-BUTOXYETHANOL                                      Date: 01/21/98  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 10:57:48  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 4| 7| 6| 6| 7| 7| 6| 6| 7| 7| 7| 6| 6| 3| 7| 0| 7| 7| 7| 7| 6| 7| 7| 7|             
                             DAY ON TEST   | 3| 0| 3| 9| 3| 3| 2| 8| 6| 2| 3| 3| 8| 0| 7| 2| 7| 2| 2| 3| 2| 7| 2| 3| 3|             
                                           | 0| 2| 0| 4| 8| 0| 9| 4| 5| 9| 0| 0| 4| 4| 4| 9| 3| 9| 9| 0| 9| 0| 9| 0| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|             
    250 PPM                                | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
      Hyperplasia                          |                2                                   2  1     2        2   |             
      Hypertrophy                          |    1  1  2  1  1        1  2  1     1  2  2        1  1  2  1     1      |             
      Capsule, Hyperplasia                 |                                                    2                     |             
                                            __________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M|             
      Hyperplasia                          |                                     1              1                     |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  A  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | M  +  +  +  M  +  M  M  +  M  M  M  +  M  +  +  +  +  M  M  M  M  M  +  +|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Pars Distalis, Hyperplasia           |                                                             2            |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Follicular Cell, Hyperplasia         |       1  1           1                                                   |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                                                          |             
      Inflammation                         |                                                          1               |             
                                            __________________________________________________________________________|             
   Preputial Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Ectasia                              |                                                                          |             
      Inflammation                         |                      2              2                          1     3  4|             
                                            __________________________________________________________________________|             
   Prostate                                | +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +|             
      Inflammation                         |             2                                1                 2         |             
      Epithelium, Hyperplasia              |             2                                                            |             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  A  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation                         |    3                                                                     |             
                                            __________________________________________________________________________|             
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                                                 2                        |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                     2        2              2  2        2|             
      Thrombosis                           |          2                                                               |             
                                            __________________________________________________________________________|             
   Lymph Node                              |                                        +                                 |             
      Renal, Hyperplasia                   |                                        2                                 |             
                                            __________________________________________________________________________|             
   Lymph Node, Bronchial                   | M  +  M  M  M  +  +  M  M  +  +  +  +  +  +  M  +  +  +  M  M  +  +  +  +|             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  M  M  +  M  +  +  M  M  M  M  M  +  M  M  +  +  +  +  M  M  +  M  M|             
      Hyperplasia                          |                                                                   3      |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  M  +  +  M  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +|             
      Angiectasis                          |          2                                                               |             
      Hyperplasia                          |          3     2     2                                            2      |             
                                            __________________________________________________________________________|             
   Lymph Node, Mediastinal                 | +  M  +  +  +  +  M  +  +  M  +  +  +  +  M  +  +  +  +  M  M  +  +  M  +|             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             

                                                             Page  58                                                               
NTP Experiment-Test: 05197-12                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          2-BUTOXYETHANOL                                      Date: 01/21/98  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 10:57:48  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 4| 7| 6| 6| 7| 7| 6| 6| 7| 7| 7| 6| 6| 3| 7| 0| 7| 7| 7| 7| 6| 7| 7| 7|             
                             DAY ON TEST   | 3| 0| 3| 9| 3| 3| 2| 8| 6| 2| 3| 3| 8| 0| 7| 2| 7| 2| 2| 3| 2| 7| 2| 3| 3|             
                                           | 0| 2| 0| 4| 8| 0| 9| 4| 5| 9| 0| 0| 4| 4| 4| 9| 3| 9| 9| 0| 9| 0| 9| 0| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|             
    250 PPM                                | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Hematopoietic Cell Proliferation     | 2  2     2  2  2  2  3     2  2  3  3  3  3  4  1  2  2     4  4  2  3  2|             
      Hyperplasia, Lymphoid                |                                                                   2      |             
      Pigmentation, Hemosiderin            | 2  2  2  2  2  2  2     3  2  2  2  2  2     2     2  2  1  2  2  2     2|             
                                            __________________________________________________________________________|             
   Thymus                                  | +  M  +  M  M  +  M  M  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  M  M|             
      Atrophy                              |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M|             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Prepuce, Hyperplasia                 |                                                                          |             
      Prepuce, Inflammation, Chronic Active|                                     4        4              4  4         |             
      Prepuce, Ulcer                       |                                     3        3              3  3         |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrous Osteodystrophy               |          1                                                               |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Vacuolization Cytoplasmic            |                                                 2                        |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Larynx                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Suppurative            |                      1                                                   |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hematopoietic Cell Proliferation     |                      4                                                   |             
      Hemorrhage                           |                                                                      1   |             
      Infiltration Cellular, Histiocyte    |       3                    1           1                                 |             
      Alveolar Epithelium, Hyperplasia     |                                                                   4      |             
      Artery, Inflammation                 |                                        2                                 |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Suppurative            |                                                          1               |             
      Glands, Hyperplasia                  |                                                             2            |             
      Olfactory Epithelium, Degeneration,  |                                                                          |             
           Hyaline                         |                                                                          |             
      Respiratory Epithelium, Degeneration,|                                                                          |             
           Hyaline                         |                1  1  1                                                   |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |       +                                      +                           |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             

                                                             Page  59                                                               
NTP Experiment-Test: 05197-12                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          2-BUTOXYETHANOL                                      Date: 01/21/98  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 10:57:48  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 4| 7| 6| 6| 7| 7| 6| 6| 7| 7| 7| 6| 6| 3| 7| 0| 7| 7| 7| 7| 6| 7| 7| 7|             
                             DAY ON TEST   | 3| 0| 3| 9| 3| 3| 2| 8| 6| 2| 3| 3| 8| 0| 7| 2| 7| 2| 2| 3| 2| 7| 2| 3| 3|             
                                           | 0| 2| 0| 4| 8| 0| 9| 4| 5| 9| 0| 0| 4| 4| 4| 9| 3| 9| 9| 0| 9| 0| 9| 0| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|             
    250 PPM                                | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
      Glomerulosclerosis                   | 1     1              2           1     2     1                       1   |             
      Hydronephrosis                       |          3           2                                      1  2         |             
      Inflammation, Chronic Active         |          4                                   2              2            |             
      Inflammation                         |                                                                3         |             
      Mineralization                       |                1                                                         |             
      Nephropathy                          | 1     1     1  1  1  2     1  1  2  1  1  1  1     1  1  1  1  1  2  1  1|             
      Capsule, Inflammation                |                                                                          |             
      Cortex, Cyst                         |                                              1     2                     |             
      Renal Tubule, Mineralization         |             2           2                                                |             
      Renal Tubule, Pigmentation           |                                                                1         |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  A  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation                         |                                              4              4  4         |             
      Transitional Epithelium, Hyperplasia |                                                                          |             
      Transitional Epithelium, Ulcer       |                                              3              3            |             
 _____________________________________________________________________________________________________________________|             

                                                             Page  60                                                               
NTP Experiment-Test: 05197-12                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          2-BUTOXYETHANOL                                      Date: 01/21/98  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 10:57:48  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 7| 7| 6| 7| 7| 6| 4| 7| 7| 4| 7| 3| 7| 3| 7| 6| 7| 7| 6| 7| 6| 7| 6| 5|            |
                             DAY ON TEST   | 9| 2| 2| 1| 3| 3| 1| 4| 1| 2| 5| 3| 6| 2| 1| 0| 2| 2| 3| 2| 3| 6| 2| 7| 9|            |
                                           | 4| 9| 9| 4| 0| 0| 3| 2| 1| 9| 4| 1| 8| 9| 2| 2| 9| 9| 0| 3| 0| 3| 9| 0| 6|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|      A     |
    250 PPM                                | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Gallbladder                             | +  +  +  +  +  +  A  A  M  +  A  +  A  +  A  +  +  +  +  A  +  +  +  +  A|  35        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A|  48        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  A  +  +  A  +  +  +  +  +  +  +  M  +  +  +  +  +  A|  45        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  A  +  +  A  +  +  +  +  +  +  +  +  A  +  +  +  +  A|  43        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  A  +  +  A  +  +  +  A  +  +  +  +  A  +  +  +  +  A|  41        |
      Inflammation                         |                                                                          |      1  2.0|
      Epithelium, Hyperplasia              |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  +  A  A  A  +  A  +  A  +  A  +  +  +  +  A  +  +  +  +  A|  38        |
      Peyer's Patch, Hyperplasia           |                                                                   3      |      1  3.0|
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  A  +  +  A  +  A  +  A  +  +  +  +  A  +  +  +  +  A|  39        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A|  49        |
      Basophilic Focus                     | X                 X  X                                                   |      3     |
      Clear Cell Focus                     |    X                                                                     |      3     |
      Eosinophilic Focus                   | X  X                       X     X                    X     X  X         |     12     |
      Hematopoietic Cell Proliferation     |                                                                          |      2  2.0|
      Inflammation                         |                                        1                    1  2         |      6  1.5|
      Karyomegaly                          |                                                                          |      1  1.0|
      Necrosis                             |          2     1  1              1                       1        1      |      9  1.2|
      Bile Duct, Cyst                      | 2                                                                        |      1  2.0|
      Kupffer Cell, Pigmentation,          |                                                                          |            |
          Hemosiderin                      | 1  1  1  1  1  1        1  1     1     1     1           1  1  1  2  2   |     30  1.2|
      Oval Cell, Hyperplasia               |                                  1                                       |      3  1.0|
                                            __________________________________________________________________________|____________|
   Mesentery                               |                                                 +                        |   1        |
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  A|  47        |
      Atrophy                              |                                                                      1   |      4  1.0|
      Cytoplasmic Alteration               |                                                                1         |      1  1.0|
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inflammation                         |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  A|  48        |
      Mineralization                       |                                                                          |      1  1.0|
      Ulcer                                |                                           2                              |      3  1.7|
      Epithelium, Hyperplasia              |    4        2  2  4        2              3     1     2     2     2      |     21  2.3|
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  A|  47        |
      Mineralization                       |                                              1                           |      2  1.0|
      Epithelium, Hyperplasia              |                                  1                                       |      1  1.0|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 __________________________________________________________________________________________________________________________________ 

  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        

                                                             Page  61                                                               
NTP Experiment-Test: 05197-12                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          2-BUTOXYETHANOL                                      Date: 01/21/98  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 10:57:48  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 7| 7| 6| 7| 7| 6| 4| 7| 7| 4| 7| 3| 7| 3| 7| 6| 7| 7| 6| 7| 6| 7| 6| 5|            |
                             DAY ON TEST   | 9| 2| 2| 1| 3| 3| 1| 4| 1| 2| 5| 3| 6| 2| 1| 0| 2| 2| 3| 2| 3| 6| 2| 7| 9|            |
                                           | 4| 9| 9| 4| 0| 0| 3| 2| 1| 9| 4| 1| 8| 9| 2| 2| 9| 9| 0| 3| 0| 3| 9| 0| 6|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|      A     |
    250 PPM                                | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 __________________________________________________________________________________________________________________________________ 
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |            |
                                           |                                                                          |            |
      Cardiomyopathy                       | 1  1  1  1  1  1  1  1  1  1     1     1  1  1  1  1  1  1  1  2  2  1  1|     47  1.1|
      Atrium, Thrombosis                   |                         3                                                |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia                          |    2  2                    2                       2                     |      9  1.9|
      Hypertrophy                          |    2  1     1  2  2        1     2                 2  1     2     1      |     27  1.4|
      Capsule, Hyperplasia                 |                            2                                   1         |      3  1.7|
                                            __________________________________________________________________________|____________|
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Hyperplasia                          |                                                       1                  |      3  1.0|
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  A|  46        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +  +  +  +  +  M  +  +  +  +  +  +  M  +  +  +  +  +  M  M  +  M  M|  31        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  M  +  +|  48        |
      Pars Distalis, Hyperplasia           |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Follicular Cell, Hyperplasia         |                                                             2     1      |      5  1.2|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia                          |                                        2                                 |      1  2.0|
      Inflammation                         |                            1           2                          1      |      4  1.3|
                                            __________________________________________________________________________|____________|
   Preputial Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M|  49        |
      Ectasia                              |                                                    4                     |      1  4.0|
      Inflammation                         |       3                                            1     1               |      8  2.1|
                                            __________________________________________________________________________|____________|
   Prostate                                | +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  A|  45        |
      Inflammation                         |                                                          2               |      4  1.8|
      Epithelium, Hyperplasia              |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  A|  46        |
      Inflammation                         |                      2                       1                           |      3  2.0|
                                            __________________________________________________________________________|____________|
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Atrophy                              |       1                          2                             1         |      4  1.5|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia                          |                                                                          |      5  2.0|
      Thrombosis                           |                                                                          |      1  2.0|
 __________________________________________________________________________________________________________________________________ 

  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        

                                                             Page  62                                                               
NTP Experiment-Test: 05197-12                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          2-BUTOXYETHANOL                                      Date: 01/21/98  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 10:57:48  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 7| 7| 6| 7| 7| 6| 4| 7| 7| 4| 7| 3| 7| 3| 7| 6| 7| 7| 6| 7| 6| 7| 6| 5|            |
                             DAY ON TEST   | 9| 2| 2| 1| 3| 3| 1| 4| 1| 2| 5| 3| 6| 2| 1| 0| 2| 2| 3| 2| 3| 6| 2| 7| 9|            |
                                           | 4| 9| 9| 4| 0| 0| 3| 2| 1| 9| 4| 1| 8| 9| 2| 2| 9| 9| 0| 3| 0| 3| 9| 0| 6|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|      A     |
    250 PPM                                | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lymph Node                              |                                                                          |   1        |
      Renal, Hyperplasia                   |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Bronchial                   | M  +  +  +  M  M  M  +  +  +  +  +  +  +  +  +  M  +  M  +  +  +  +  +  +|  35        |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | M  +  +  M  +  +  M  M  M  +  M  M  +  +  M  M  +  +  M  +  +  +  +  +  M|  25        |
      Hyperplasia                          |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  A|  43        |
      Angiectasis                          |                                                                          |      1  2.0|
      Hyperplasia                          |                                                                          |      4  2.3|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mediastinal                 | +  +  +  +  M  M  +  M  +  +  +  +  +  +  M  +  +  +  +  M  +  +  M  +  +|  37        |
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A|  49        |
      Hematopoietic Cell Proliferation     | 2     2  3  2     2  2  3  2  3  2  2  3     2  4  1  2  2     2  3  3   |     42  2.4|
      Hyperplasia, Lymphoid                |                                                                          |      1  2.0|
      Pigmentation, Hemosiderin            | 2  2  2  1  1  2  2  2  2  2     2  2  2  2  1  1  2  2  2  2  2  2  2   |     44  1.9|
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +  M  M  +  +  M  M  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +|  37        |
      Atrophy                              |                                                          4               |      1  4.0|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M|            |
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Prepuce, Hyperplasia                 |       1                                                           1      |      2  1.0|
      Prepuce, Inflammation, Chronic Active| 3                                      4                             4  4|      8  3.9|
      Prepuce, Ulcer                       | 1                                      2                             2  3|      8  2.5|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Fibrous Osteodystrophy               |                                                                          |      1  1.0|
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Vacuolization Cytoplasmic            |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Larynx                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A|  49        |
      Inflammation, Suppurative            |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hematopoietic Cell Proliferation     |                                                                          |      1  4.0|
      Hemorrhage                           |          1                                      1                        |      3  1.0|
      Infiltration Cellular, Histiocyte    |             3                                                            |      4  2.0|
      Alveolar Epithelium, Hyperplasia     |                            1     2                                2      |      4  2.3|
 __________________________________________________________________________________________________________________________________ 

  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        

                                                             Page  63                                                               
NTP Experiment-Test: 05197-12                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          2-BUTOXYETHANOL                                      Date: 01/21/98  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 10:57:48  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 7| 7| 6| 7| 7| 6| 4| 7| 7| 4| 7| 3| 7| 3| 7| 6| 7| 7| 6| 7| 6| 7| 6| 5|            |
                             DAY ON TEST   | 9| 2| 2| 1| 3| 3| 1| 4| 1| 2| 5| 3| 6| 2| 1| 0| 2| 2| 3| 2| 3| 6| 2| 7| 9|            |
                                           | 4| 9| 9| 4| 0| 0| 3| 2| 1| 9| 4| 1| 8| 9| 2| 2| 9| 9| 0| 3| 0| 3| 9| 0| 6|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|      A     |
    250 PPM                                | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 __________________________________________________________________________________________________________________________________ 
 RESPIRATORY SYSTEM - cont                 |                                                                          |            |
                                           |                                                                          |            |
      Artery, Inflammation                 |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A|  48        |
      Inflammation, Suppurative            |                                                             1            |      2  1.0|
      Glands, Hyperplasia                  |                                                                          |      1  2.0|
      Olfactory Epithelium, Degeneration,  |                                                                          |            |
           Hyaline                         |                                                                   1      |      1  1.0|
      Respiratory Epithelium, Degeneration,|                                                                          |            |
           Hyaline                         |                                                 1  1                     |      5  1.0|
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A|  49        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Harderian Gland                         |                                                                          |   2        |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Glomerulosclerosis                   |                   2           2                                          |      9  1.4|
      Hydronephrosis                       |                                                                         3|      5  2.2|
      Inflammation, Chronic Active         |                                                          4               |      4  3.0|
      Inflammation                         |                                                                          |      1  3.0|
      Mineralization                       |                                                                   1      |      2  1.0|
      Nephropathy                          | 1  1  1     1  1  2     1  1     1     1     1  1           1  1  2  2   |     37  1.2|
      Capsule, Inflammation                |                                                                      2   |      1  2.0|
      Cortex, Cyst                         | 1     2                                      2        2                  |      6  1.7|
      Renal Tubule, Mineralization         |                                                                          |      2  2.0|
      Renal Tubule, Pigmentation           |                   1                                               1      |      3  1.0|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  A  +  +  +  A  +  +  +  +  +  +  +  +  +  A|  45        |
      Inflammation                         |                                                          3               |      4  3.8|
      Transitional Epithelium, Hyperplasia |                                                          3               |      1  3.0|
      Transitional Epithelium, Ulcer       |                                                                          |      2  3.0|
 __________________________________________________________________________________________________________________________________ 

  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        

                                                             Page  64                                                               
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                             ----------              END OF REPORT             ----------                                           
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